Aspirin withdrawal in complex PCI and diabetes
Nature Reviews Cardiology, Published online: 07 April 2020; doi:10.1038/s41569-020-0376-xAspirin withdrawal in complex PCI and diabetes (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 7, 2020 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Rivaroxaban prevents VTE in orthopaedic surgery
Nature Reviews Cardiology, Published online: 07 April 2020; doi:10.1038/s41569-020-0377-9Rivaroxaban prevents VTE in orthopaedic surgery (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 7, 2020 Category: Cardiology Authors: Gregory B. Lim Source Type: research

BP-lowering with renal denervation
Nature Reviews Cardiology, Published online: 07 April 2020; doi:10.1038/s41569-020-0380-1Renal denervation compared with a sham procedure can significantly reduce 24-h and office systolic blood pressure levels in patients with uncontrolled hypertension who are not receiving antihypertensive drugs. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 7, 2020 Category: Cardiology Authors: Karina Huynh Source Type: research

Estimating ejection fraction by video-based AI
Nature Reviews Cardiology, Published online: 07 April 2020; doi:10.1038/s41569-020-0375-yEstimating ejection fraction by video-based AI (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 7, 2020 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Antithrombotic therapy after TAVI
Nature Reviews Cardiology, Published online: 07 April 2020; doi:10.1038/s41569-020-0378-8The combination of oral anticoagulation and the antiplatelet drug clopidogrel increases the risk of bleeding after transcatheter aortic valve implantation (TAVI) compared with oral anticoagulation alone, according to the results of the POPular TAVI trial cohort B. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 7, 2020 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Cybersecurity and cardiac implantable electronic devices
Nature Reviews Cardiology, Published online: 03 April 2020; doi:10.1038/s41569-020-0372-1Cybersecurity vulnerabilities of cardiac implantable electronic devices have been an area of increasing concern in the past 4 years. Physicians should be informed of these issues as they evolve so they can counsel their patients with the most accurate and up-to-date information. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - April 3, 2020 Category: Cardiology Authors: Bryce Alexander Adrian Baranchuk Source Type: research

Twice-yearly inclisiran injections halve LDL-cholesterol levels
Nature Reviews Cardiology, Published online: 31 March 2020; doi:10.1038/s41569-020-0373-0The safety and durability of the LDL-cholesterol-lowering effects of inclisiran, a small interfering RNA that inhibits the synthesis of PCSK9 in the liver, have now been confirmed in three phase III clinical trials published in the New England Journal of Medicine. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 31, 2020 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
Nature Reviews Cardiology, Published online: 30 March 2020; doi:10.1038/s41569-020-0348-1The cardiotoxicity spectrum of cancer therapies has broadened and is gaining increasing importance with an ever-growing repertoire of therapeutics. This Review provides an updated overview of cardiotoxicity and arrhythmias associated with cancer therapies, summarizing the latest developments at the juncture of cardiology, oncology and haematology and the emerging field of cardio-oncology. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 30, 2020 Category: Cardiology Authors: Joerg Herrmann Source Type: research

Single-cell RNA sequencing in cardiovascular development, disease and medicine
Nature Reviews Cardiology, Published online: 30 March 2020; doi:10.1038/s41569-020-0359-ySingle-cell RNA sequencing (scRNA-seq) technologies have helped to identify rare cell populations and allowed the comparison of healthy and diseased tissues at single-cell resolution. This Review discusses the available scRNA-seq tools and summarizes the scRNA-seq findings that have contributed to our understanding of cardiovascular development and disease. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 30, 2020 Category: Cardiology Authors: David T. Paik Sangkyun Cho Lei Tian Howard Y. Chang Joseph C. Wu Source Type: research

Evaluation and management of heart failure with preserved ejection fraction
Nature Reviews Cardiology, Published online: 30 March 2020; doi:10.1038/s41569-020-0363-2Heart failure with preserved ejection fraction (HFpEF) is the predominant form of heart failure among elderly patients. In this Review, Borlaug describes the challenges of diagnosing HFpEF, summarizes the current recommendations for treatment and describes a new strategy of categorizing patients with HFpEF into phenotypically homogeneous subgroups to facilitate the individualization of treatment. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 30, 2020 Category: Cardiology Authors: Barry A. Borlaug Source Type: research

Cardiovascular effects of electronic cigarettes
Nature Reviews Cardiology, Published online: 30 March 2020; doi:10.1038/s41569-020-0370-3The available literature suggests that electronic cigarettes (e-cigarettes), although not without risk, might decrease cardiovascular risk in chronic smokers of tobacco cigarettes who switch to e-cigarettes. However, to safeguard our youth, e-cigarettes must be required to meet product standards, all flavourings must be banned and laws regulating e-cigarette sales must be strictly enforced. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 30, 2020 Category: Cardiology Authors: Holly R. Middlekauff Source Type: research

Interaction between RAAS inhibitors and ACE2 in the context of COVID-19
Nature Reviews Cardiology, Published online: 30 March 2020; doi:10.1038/s41569-020-0368-xInteraction between RAAS inhibitors and ACE2 in the context of COVID-19 (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 30, 2020 Category: Cardiology Authors: Jean-Jacques Mourad Bernard I. Levy Source Type: research

Reply to: ‘Interaction between RAAS inhibitors and ACE2 in the context of COVID-19’
Nature Reviews Cardiology, Published online: 30 March 2020; doi:10.1038/s41569-020-0369-9Reply to: ‘Interaction between RAAS inhibitors and ACE2 in the context of COVID-19’ (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 30, 2020 Category: Cardiology Authors: Ying-Ying Zheng Yi-Tong Ma Jin-Ying Zhang Xiang Xie Source Type: research

Is salt substitution ready for prime time?
Nature Reviews Cardiology, Published online: 27 March 2020; doi:10.1038/s41569-020-0365-0Salt substitutes hold great potential for the control of blood pressure and prevention of chronic disease, but the evidence base remains inadequate. Data from a community-based trial in Peru add to this evidence base and support the conduct of large-scale trials to drive the global uptake of salt substitution. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 27, 2020 Category: Cardiology Authors: Bruce Neal Matti Marklund Source Type: research

Vascular toxic effects of cancer therapies
Nature Reviews Cardiology, Published online: 26 March 2020; doi:10.1038/s41569-020-0347-2This Review outlines the mechanisms of cancer therapy-related vascular toxicity and provides recommendations for screening, treatment and prevention in the context of available evidence and society guidelines. The Review focuses on the main types of arterial toxicity, acute vasospasm, acute thrombosis and accelerated atherosclerosis, and provides an update on cancer therapy-related venous thromboembolism and pulmonary hypertension. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 26, 2020 Category: Cardiology Authors: Joerg Herrmann Source Type: research

Novel gut microbiota-derived metabolite promotes platelet thrombosis via adrenergic receptor signalling
Nature Reviews Cardiology, Published online: 24 March 2020; doi:10.1038/s41569-020-0367-yA novel metabolite derived from gut microbiota has been shown to promote platelet hyper-responsiveness and modulate platelet function via adrenergic receptors, contributing to increased thrombotic risk. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 24, 2020 Category: Cardiology Authors: Karina Huynh Source Type: research

T cell subsets and functions in atherosclerosis
Nature Reviews Cardiology, Published online: 16 March 2020; doi:10.1038/s41569-020-0352-5Accumulating evidence supports the critical role of T cells as drivers and modifiers of atherosclerosis. In this Review, Ley and colleagues describe the latest advances in our understanding of the role of T cell subsets in atherosclerosis, discuss the process of T cell homing to atherosclerotic plaques and highlight potential T cell-related therapies for atherosclerosis. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 16, 2020 Category: Cardiology Authors: Ryosuke Saigusa Holger Winkels Klaus Ley Source Type: research

Previous MI attenuates emergency haematopoiesis and inflammation
Nature Reviews Cardiology, Published online: 10 March 2020; doi:10.1038/s41569-020-0362-3A surgical mouse model of recurrent myocardial infarction (MI) developed by inducing two sequential MIs in different regions of the same mouse revealed that haematopoietic and innate immune responses are shaped by a preceding MI. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 10, 2020 Category: Cardiology Authors: Karina Huynh Source Type: research

Inhibiting fatty acid oxidation promotes cardiomyocyte proliferation
Nature Reviews Cardiology, Published online: 09 March 2020; doi:10.1038/s41569-020-0361-4Inhibition of fatty acid metabolism to promote oxidation of glycolysis-derived pyruvate promotes cardiomyocyte proliferation and improves left ventricular function after myocardial infarction. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 9, 2020 Category: Cardiology Authors: Gregory B. Lim Source Type: research

The effects of endurance exercise on the heart: panacea or poison?
Nature Reviews Cardiology, Published online: 09 March 2020; doi:10.1038/s41569-020-0354-3Moderate exercise improves cardiovascular health and is associated with physiological cardiac adaptations; by contrast, the hearts of endurance athletes can undergo maladaptations, including myocardial fibrosis and arrhythmias. In this Review, Parry-Williams and Sharma discuss whether excessive endurance exercise might damage both diseased and otherwise normal hearts. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 9, 2020 Category: Cardiology Authors: Gemma Parry-Williams Sanjay Sharma Source Type: research

COVID-19 and the cardiovascular system
Nature Reviews Cardiology, Published online: 05 March 2020; doi:10.1038/s41569-020-0360-5Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells through ACE2 receptors, leading to coronavirus disease (COVID-19)-related pneumonia, while also causing acute myocardial injury and chronic damage to the cardiovascular system. Therefore, particular attention should be given to cardiovascular protection during treatment for COVID-19. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - March 5, 2020 Category: Cardiology Authors: Ying-Ying Zheng Yi-Tong Ma Jin-Ying Zhang Xiang Xie Source Type: research

Plexin D1 is a mechanosensor that regulates the site-specific distribution of atherosclerosis
Nature Reviews Cardiology, Published online: 25 February 2020; doi:10.1038/s41569-020-0355-2A study published in Nature identifies the semaphorin receptor plexin D1 as a novel mechanoreceptor in endothelial cells that regulates vascular function and the site-specific distribution of atherosclerosis. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 25, 2020 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

LVAD versus balloon pump in patients with AMI
Nature Reviews Cardiology, Published online: 25 February 2020; doi:10.1038/s41569-020-0357-0LVAD versus balloon pump in patients with AMI (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 25, 2020 Category: Cardiology Authors: Karina Huynh Source Type: research

Ketogenesis in arrhythmogenic cardiomyopathy
Nature Reviews Cardiology, Published online: 25 February 2020; doi:10.1038/s41569-020-0356-1Ketogenesis in arrhythmogenic cardiomyopathy (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 25, 2020 Category: Cardiology Authors: Karina Huynh Source Type: research

Cocoa might improve walking performance in PAD
Nature Reviews Cardiology, Published online: 25 February 2020; doi:10.1038/s41569-020-0358-zCocoa might improve walking performance in PAD (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 25, 2020 Category: Cardiology Authors: Karina Huynh Source Type: research

Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia
Nature Reviews Cardiology, Published online: 24 February 2020; doi:10.1038/s41569-020-0341-8Cardiac imaging has a pivotal role in the prevention, diagnosis and treatment of ischaemic heart disease. In this Consensus Statement, the authors summarize the use of SPECT, PET, MRI, echocardiography, CT and invasive coronary flow and pressure measurement, and describe the relative strengths and weaknesses of each modality. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 24, 2020 Category: Cardiology Authors: Marc Dewey Maria Siebes Marc Kachelrie ß Klaus F. Kofoed P ál Maurovich-Horvat Konstantin Nikolaou Wenjia Bai Andreas Kofler Robert Manka Sebastian Kozerke Amedeo Chiribiri Tobias Schaeffter Florian Michallek Frank Bengel Stephan Nekolla Paul Knaapen Ma Source Type: research

Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence
Nature Reviews Cardiology, Published online: 20 February 2020; doi:10.1038/s41569-020-0339-2Diabetic cardiomyopathy occurs as a result of the dysregulated glucose and lipid metabolism, increased oxidative stress and activation of pro-inflammatory pathways associated with diabetes mellitus, which can induce cardiac remodelling and dysfunction. In this Review, Tan and colleagues discuss the pathogenesis of diabetic cardiomyopathy and describe signalling pathways that might be potential therapeutic targets. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 20, 2020 Category: Cardiology Authors: Yi Tan Zhiguo Zhang Chao Zheng Kupper A. Wintergerst Bradley B. Keller Lu Cai Source Type: research

Macrophages produce collagen for myocardial scar formation
Nature Reviews Cardiology, Published online: 17 February 2020; doi:10.1038/s41569-020-0353-4Macrophages directly contribute collagen to scar formation as part of heart regeneration in zebrafish and heart repair in mice; this finding develops the current paradigm of collagen deposition for scar formation being generated exclusively via macrophage-mediated activation of cardiac fibroblasts to myofibroblasts. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 17, 2020 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Dual apoC-II mimetic and apoC-III antagonist for hypertriglyceridaemia
Nature Reviews Cardiology, Published online: 13 February 2020; doi:10.1038/s41569-020-0351-6D6PV, a dual apolipoprotein C-II mimetic and apolipoprotein C-III antagonist, increases triglyceride lipolysis in mouse models of hypertriglyceridaemia. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 13, 2020 Category: Cardiology Authors: Karina Huynh Source Type: research

Neighbourhood built environment and cardiovascular disease: knowledge and future directions
Nature Reviews Cardiology, Published online: 12 February 2020; doi:10.1038/s41569-020-0343-6Awareness of the effect of the neighbourhood built environment on cardiovascular diseases is growing. In this Comment, we identify major conceptual, methodological and policy-relevant issues in research related to the built environment and describe potential future directions to improve the scientific rigour of research in this field. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 12, 2020 Category: Cardiology Authors: Mohammad Javad Koohsari Gavin R. McCormack Tomoki Nakaya Koichiro Oka Source Type: research

New developments in gene editing for Duchenne muscular dystrophy
Nature Reviews Cardiology, Published online: 11 February 2020; doi:10.1038/s41569-020-0350-7A somatic gene editing therapy for the treatment of Duchenne muscular dystrophy (DMD) improves skeletal and cardiac muscle function and reduces cardiac arrhythmogenic vulnerability in a pig model of DMD and an in vitro model of human DMD. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 11, 2020 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Diagnostic imaging of cardiac amyloidosis
Nature Reviews Cardiology, Published online: 10 February 2020; doi:10.1038/s41569-020-0334-7Cardiac amyloidosis is a life-threatening cause of restrictive cardiomyopathy that is often underdiagnosed or misdiagnosed. This Review summarizes the latest non-invasive imaging techniques used to diagnose cardiac amyloidosis, including echocardiography, bone scintigraphy and cardiac MRI. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 10, 2020 Category: Cardiology Authors: Ana Martinez-Naharro A. John Baksi Philip N. Hawkins Marianna Fontana Source Type: research

Reappraisal of LQTS-causing genes
Nature Reviews Cardiology, Published online: 10 February 2020; doi:10.1038/s41569-020-0349-0Long QT syndrome (LQTS) is the most common inherited cardiac arrhythmia and has been associated with mutations in 17 different genes; however, the evidence that many of these genes are actually causative for LQTS is limited or disputed. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 10, 2020 Category: Cardiology Authors: Gregory B. Lim Source Type: research

5-year safety of TAVI in intermediate-risk patients
Nature Reviews Cardiology, Published online: 06 February 2020; doi:10.1038/s41569-020-0346-35-year safety of TAVI in intermediate-risk patients (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 6, 2020 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Coconut oil raises LDL-cholesterol levels
Nature Reviews Cardiology, Published online: 06 February 2020; doi:10.1038/s41569-020-0345-4Coconut oil raises LDL-cholesterol levels (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 6, 2020 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Sphingolipids are biomarkers of coronary disease
Nature Reviews Cardiology, Published online: 06 February 2020; doi:10.1038/s41569-020-0344-5Sphingolipids are biomarkers of coronary disease (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 6, 2020 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Nature Reviews Cardiology, Published online: 03 February 2020; doi:10.1038/s41569-019-0331-xIn this Review, Murry and colleagues describe the hallmarks of cardiomyocyte maturation and the current approaches to mature stem cell-derived cardiomyocytes, highlighting challenges and future directions to generate cardiomyocytes with an optimal maturation state for use in research and regenerative medicine. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - February 3, 2020 Category: Cardiology Authors: Elaheh Karbassi Aidan Fenix Silvia Marchiano Naoto Muraoka Kenta Nakamura Xiulan Yang Charles E. Murry Source Type: research

Neutrophils as regulators of cardiovascular inflammation
Nature Reviews Cardiology, Published online: 29 January 2020; doi:10.1038/s41569-019-0326-7In this Review, Soehnlein and colleagues discuss the role of neutrophils in cardiovascular inflammation and repair, describing the effect of cardiovascular risk factors on neutrophil production and function, appraising the contribution of neutrophils to the different stages of atherosclerosis and its clinical manifestations, and highlighting the evolving therapeutic strategies for targeting neutrophil numbers, functional status and effector mechanisms. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 29, 2020 Category: Cardiology Authors: Carlos Silvestre-Roig Quinte Braster Almudena Ortega-Gomez Oliver Soehnlein Source Type: research

Important distinction between acute coronary syndromes and Takotsubo syndrome
Nature Reviews Cardiology, Published online: 29 January 2020; doi:10.1038/s41569-020-0342-7Important distinction between acute coronary syndromes and Takotsubo syndrome (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 29, 2020 Category: Cardiology Authors: Vincenzo Marafioti Giulia Turri Salvatore Monaco Source Type: research

Intracoronary mitochondrial transplantation
Nature Reviews Cardiology, Published online: 24 January 2020; doi:10.1038/s41569-020-0340-9Autologous mitochondrial transplantation for myocardial protection is feasible, safe and beneficial; however, the mechanisms by which these effects are achieved are uncertain. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 24, 2020 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Platelet-derived growth factor AB promotes wound repair after MI
Nature Reviews Cardiology, Published online: 23 January 2020; doi:10.1038/s41569-020-0338-3Intravenous infusion of a platelet-derived growth factor promoted wound healing and increased survival in a pig model of myocardial infarction. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 23, 2020 Category: Cardiology Authors: Karina Huynh Source Type: research

Familial hypercholesterolaemia: evolving knowledge for designing adaptive models of care
Nature Reviews Cardiology, Published online: 23 January 2020; doi:10.1038/s41569-019-0325-8Familial hypercholesterolaemia is a genetic disorder that impairs the hepatic clearance of LDL, leading to premature atherosclerotic cardiovascular disease. In this Review, Watts and colleagues summarize the latest advances that can inform the development and implementation of new models of care for familial hypercholesterolaemia. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 23, 2020 Category: Cardiology Authors: Gerald F. Watts Samuel S. Gidding Pedro Mata Jing Pang David R. Sullivan Shizuya Yamashita Frederick J. Raal Raul D. Santos Kausik K. Ray Source Type: research

Reappraising the role of inflammation in heart failure
Nature Reviews Cardiology, Published online: 22 January 2020; doi:10.1038/s41569-019-0315-xInflammation has an important role in the pathogenesis of acute and chronic heart failure. This Review summarizes the latest findings on the role of the innate and adaptive immune systems in the pathogenesis of heart failure, and highlights the results of phase III clinical trials of therapies targeting inflammatory processes in this condition, such as anti-inflammatory and immunomodulatory strategies. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 22, 2020 Category: Cardiology Authors: Luigi Adamo Cibele Rocha-Resende Sumanth D. Prabhu Douglas L. Mann Source Type: research

Dual-pathway inhibition for secondary and tertiary antithrombotic prevention in cardiovascular disease
Nature Reviews Cardiology, Published online: 17 January 2020; doi:10.1038/s41569-019-0314-yMany patients with cardiovascular disease have a residual risk of ischaemic events despite receiving antiplatelet therapy. In this Review, Angiolillo and colleagues discuss the pharmacological rationale and clinical development of dual-pathway inhibition strategies for the prevention of atherothrombotic events in patients with cardiovascular disease. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 17, 2020 Category: Cardiology Authors: Davide Capodanno Deepak L. Bhatt John W. Eikelboom Keith A. A. Fox Tobias Geisler C. Michael Gibson Jose Ramon Gonzalez-Juanatey Stefan James Renato D. Lopes Roxana Mehran Gilles Montalescot Manesh Patel P. Gabriel Steg Robert F. Storey Pascal Vranckx Jef Source Type: research

AKCEA-APO(a)-LRx lowers Lp(a) levels in patients
Nature Reviews Cardiology, Published online: 16 January 2020; doi:10.1038/s41569-020-0336-5AKCEA-APO(a)-LRx lowers Lp(a) levels in patients (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 16, 2020 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

HDACs as a therapeutic target in HFpEF
Nature Reviews Cardiology, Published online: 16 January 2020; doi:10.1038/s41569-020-0335-6HDACs as a therapeutic target in HFpEF (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 16, 2020 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

The challenge of an expanded therapeutic window in pulmonary hypertension
Nature Reviews Cardiology, Published online: 16 January 2020; doi:10.1038/s41569-020-0332-9Our understanding of the causes and consequences of pulmonary hypertension is limited. Consequently, its most distinctive forms with the worst prognosis have been the focus for diagnosis and treatment. We highlight the emerging challenge of reframing the prevalence and prognostic implications of pulmonary hypertension, focusing on the optimal therapeutic window to address the high mortality linked to this condition. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 16, 2020 Category: Cardiology Authors: Simon Stewart Geoffrey A. Strange David Playford Source Type: research

Alcohol abstinence reduces AF recurrence
Nature Reviews Cardiology, Published online: 16 January 2020; doi:10.1038/s41569-020-0337-4Alcohol abstinence reduces AF recurrence (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 16, 2020 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Reappraisal of the safety and effectiveness of Impella pumps
Nature Reviews Cardiology, Published online: 14 January 2020; doi:10.1038/s41569-020-0333-8In the decade after the introduction of Impella heart pumps, their use has rapidly increased. However, to date, clinical trial data have not conclusively supported their superiority over other contemporary support devices, and observational experiences have identified signals of increased harm with Impella. Large, adequately powered clinical trials of Impella are eagerly awaited. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - January 14, 2020 Category: Cardiology Authors: Muthiah Vaduganathan Mandeep R. Mehra Source Type: research

The Apple Watch can detect atrial fibrillation: so what now?
Nature Reviews Cardiology, Published online: 23 December 2019; doi:10.1038/s41569-019-0330-yThe Apple Heart Study demonstrates that the Apple Watch can detect atrial fibrillation inferred from the smartwatch heart-rate sensor with a high positive predictive value. However, we must now contend with many clinically relevant unknowns that were not addressed by the study, such as the ramifications of a false-positive result. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - December 23, 2019 Category: Cardiology Authors: Gregory M. Marcus Source Type: research