β-Blockers rescue cardiomyocyte division defects
Nature Reviews Cardiology, Published online: 22 October 2019; doi:10.1038/s41569-019-0302-2β-Blockers rescue cardiomyocyte division defects (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 22, 2019 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Hypothermia helps in nonshockable cardiac arrest
Nature Reviews Cardiology, Published online: 22 October 2019; doi:10.1038/s41569-019-0301-3Hypothermia helps in nonshockable cardiac arrest (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 22, 2019 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Circadian regulators as a therapeutic target in MI
Nature Reviews Cardiology, Published online: 22 October 2019; doi:10.1038/s41569-019-0303-1Circadian regulators as a therapeutic target in MI (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 22, 2019 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Drug dosing for heart failure: does sex or size matter?
Nature Reviews Cardiology, Published online: 18 October 2019; doi:10.1038/s41569-019-0298-7Results from a prospective study by Santema and colleagues suggest that women with heart failure and reduced ejection fraction might need lower doses of standard heart failure drugs than men. However, this conclusion was formed on the basis of data from a small proportion of the population studied and might only be relevant to participants taking β-blockers. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 18, 2019 Category: Cardiology Authors: Andrew J. S. Coats Source Type: research

NIRS to identify vulnerable plaques
Nature Reviews Cardiology, Published online: 15 October 2019; doi:10.1038/s41569-019-0299-6Near-infrared spectroscopy–intravascular ultrasonography of mildly or non-obstructive coronary arteries in patients with suspected coronary artery disease undergoing catheterization and possible percutaneous coronary intervention is safe and can detect both patients and non-culprit vulnerable plaques at high risk of secondary coronary events (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 15, 2019 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Prime time for ticagrelor monotherapy
Nature Reviews Cardiology, Published online: 14 October 2019; doi:10.1038/s41569-019-0300-4The TWILIGHT trial indicates that switching to ticagrelor monotherapy after 3 months of dual antiplatelet therapy lowers the incidence of bleeding without increasing ischaemic events compared with continuation of ticagrelor plus aspirin therapy in patients who have undergone percutaneous coronary intervention and are at high risk of bleeding or ischaemic events (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 14, 2019 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Genetics of dilated cardiomyopathy: practical implications for heart failure management
Nature Reviews Cardiology, Published online: 11 October 2019; doi:10.1038/s41569-019-0284-0In this Review, Rosenbaum and colleagues give a broad perspective on the genetic causes of dilated cardiomyopathy to provide a context for a discussion of the pragmatic use of genetic testing in heart failure clinics for patients presenting with new-onset dilated cardiomyopathy. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 11, 2019 Category: Cardiology Authors: Andrew N. Rosenbaum Katherine E. Agre Naveen L. Pereira Source Type: research

Integrating blockchain technology with artificial intelligence for cardiovascular medicine
Nature Reviews Cardiology, Published online: 11 October 2019; doi:10.1038/s41569-019-0294-yArtificial intelligence (AI) holds promise for cardiovascular medicine but is limited by a lack of large, heterogeneous and granular data sets. Blockchain provides secure interoperability between siloed stakeholders and centralized data sources. We discuss integration of blockchain with AI for data-centric analysis and information flow, its current limitations and potential cardiovascular applications. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 11, 2019 Category: Cardiology Authors: Chayakrit Krittanawong Albert J. Rogers Mehmet Aydar Edward Choi Kipp W. Johnson Zhen Wang Sanjiv M. Narayan Source Type: research

Myocardial viability and CABG surgery: a Bayesian appraisal of STICH
Nature Reviews Cardiology, Published online: 09 October 2019; doi:10.1038/s41569-019-0292-0The myocardial viability substudy from the STICH trial has reaffirmed the 10-year survival benefit of CABG surgery in patients with left ventricular dysfunction, but whether myocardial viability must be present for the long-term benefits of revascularization to be realized remains inconclusive. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 9, 2019 Category: Cardiology Authors: Bj örn Redfors Gregg W. Stone Source Type: research

Publisher Correction: The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies
Nature Reviews Cardiology, Published online: 08 October 2019; doi:10.1038/s41569-019-0297-8Publisher Correction: The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 8, 2019 Category: Cardiology Authors: Neil Herring Manish Kalla David J. Paterson Source Type: research

NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets
Nature Reviews Cardiology, Published online: 07 October 2019; doi:10.1038/s41569-019-0260-8In this Review, Cai and colleagues discuss the complex crosstalk between different oxidase systems and the consequences of this crosstalk in mediating cardiovascular disease processes, focusing on the central role of particular NADPH oxidase isoforms activated in specific cardiovascular diseases. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 7, 2019 Category: Cardiology Authors: Yixuan Zhang Priya Murugesan Kai Huang Hua Cai Source Type: research

Remote ischaemic conditioning: in search of a suitable match
Nature Reviews Cardiology, Published online: 07 October 2019; doi:10.1038/s41569-019-0296-9Preclinical data and small clinical trials suggest that remote ischaemic conditioning (RIC) therapy protects patients with acute myocardial infarction undergoing percutaneous coronary intervention. In the CONDI-2/ERIC-PPCI trial, RIC proved to be safe but did not have any short-term benefits in reducing cardiac-related death and hospitalization for heart failure. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 7, 2019 Category: Cardiology Authors: Martin Cour Sandrine Lecour Source Type: research

Epidemiology of inherited arrhythmias
Nature Reviews Cardiology, Published online: 03 October 2019; doi:10.1038/s41569-019-0266-2Inherited arrhythmias are a major cause of sudden cardiac death, particularly among young individuals. In this Review, Offerhaus and colleagues provide an overview of the epidemiology of inherited ventricular arrhythmias, focusing on natural history, prevalence and patient demographics. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 3, 2019 Category: Cardiology Authors: Joost A. Offerhaus Connie R. Bezzina Arthur A. M. Wilde Source Type: research

Non-atherosclerotic causes of acute coronary syndromes
Nature Reviews Cardiology, Published online: 03 October 2019; doi:10.1038/s41569-019-0273-3Non-atherosclerotic processes are important contributors to a substantial number of acute coronary syndrome events. In this Review, Gulati and colleagues discuss the diagnosis, management and prognosis of patients with spontaneous coronary artery dissection, coronary artery embolism, vasospasm, myocardial bridging or stress-induced cardiomyopathy (Takotsubo syndrome). (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 3, 2019 Category: Cardiology Authors: Thomas M. Waterbury Giuseppe Tarantini Birgit Vogel Roxana Mehran Bernard J. Gersh Rajiv Gulati Source Type: research

Transcriptional and epigenetic regulation of macrophages in atherosclerosis
Nature Reviews Cardiology, Published online: 02 October 2019; doi:10.1038/s41569-019-0265-3This Review summarizes the role of transcription factors and epigenetic remodelling in modulating macrophage plasticity, provides an overview of the cooperative action of transcription factors and epigenetic modifiers controlling macrophage activation in the context of atherosclerosis and inflammation, and highlights the therapeutic potential of modulating transcription factor activity. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 2, 2019 Category: Cardiology Authors: Tatyana Kuznetsova Koen H. M. Prange Christopher K. Glass Menno P. J. de Winther Source Type: research

Benefit of polypills in a low socioeconomic community in the USA
Nature Reviews Cardiology, Published online: 02 October 2019; doi:10.1038/s41569-019-0295-xIn a socioeconomically vulnerable community in Alabama, USA, the use of a polypill containing four low-dose drugs produced greater reductions in blood pressure and LDL-cholesterol level than usual care. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 2, 2019 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Dapagliflozin — a breakthrough in the search for drugs to treat HFrEF
Nature Reviews Cardiology, Published online: 02 October 2019; doi:10.1038/s41569-019-0291-1Results from the DAPA-HF trial demonstrate that dapagliflozin therapy is associated with lower risk of worsening heart failure or cardiovascular death than placebo, regardless of the presence or absence of diabetes. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 2, 2019 Category: Cardiology Authors: Karina Huynh Source Type: research

Publisher Correction: The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies
Nature Reviews Cardiology, Published online: 02 October 2019; doi:10.1038/s41569-019-0293-zPublisher Correction: The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - October 2, 2019 Category: Cardiology Authors: Neil Herring Manish Kalla David J. Paterson Source Type: research

Precision cardiology in the digital era
Nature Reviews Cardiology, Published online: 30 September 2019; doi:10.1038/s41569-019-0285-zAs Nature Reviews Cardiology marks its 15th anniversary, we are entering a new era of precision cardiology, driven by drug development, technological innovation and artificial intelligence. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 30, 2019 Category: Cardiology Source Type: research

Looking back and thinking forwards — 15 years of cardiology and cardiovascular research
Nature Reviews Cardiology, Published online: 30 September 2019; doi:10.1038/s41569-019-0261-7November 2019 marks 15 years since the launch of Nature Reviews Cardiology. To celebrate, we invited six of our Advisory Board members to discuss some of the highlights of cardiovascular research in the past 15 years and to make some projections about scientific research in the next 15 years. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 30, 2019 Category: Cardiology Authors: Jonathan M. Kalman Sergio Lavandero Felix Mahfoud Matthias Nahrendorf Magdi H. Yacoub Dong Zhao Source Type: research

CAR T cells combat cardiac fibrosis
Nature Reviews Cardiology, Published online: 25 September 2019; doi:10.1038/s41569-019-0287-xEngineered chimeric antigen receptor (CAR) T cells can be applied to reduce cardiac fibrosis and restore function in a mouse model of hypertensive heart failure, according to a new study published in Nature. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 25, 2019 Category: Cardiology Authors: Sarah Crunkhorn Source Type: research

Bleeding linked with new diagnosis of cancer
Nature Reviews Cardiology, Published online: 24 September 2019; doi:10.1038/s41569-019-0288-9Bleeding linked with new diagnosis of cancer (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 24, 2019 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Neurohormonal activation in HFpEF
Nature Reviews Cardiology, Published online: 24 September 2019; doi:10.1038/s41569-019-0290-2Neurohormonal activation in HFpEF (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 24, 2019 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Evolutionary adaptations of human hearts
Nature Reviews Cardiology, Published online: 24 September 2019; doi:10.1038/s41569-019-0289-8Evolutionary adaptations of human hearts (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 24, 2019 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Cardiovascular medicine and research in sub-Saharan Africa: challenges and opportunities
Nature Reviews Cardiology, Published online: 24 September 2019; doi:10.1038/s41569-019-0269-zAfrica is witnessing an epidemic of cardiovascular disease (CVD), with staggering morbidity and mortality. The spectrum of CVD includes hypertension, rheumatic heart disease, cardiomyopathy, atherosclerotic disease, congenital heart disease and tuberculous pericarditis. Opportunities exist to alter the trajectory of CVD epidemiology but require committed policy makers, functional health systems and an engaged citizenry. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 24, 2019 Category: Cardiology Authors: Liesl Z ühlke Karen Sliwa Pamela Naidoo Hopewell Ntsinjana Mpiko Ntsekhe Farrel Hellig Francis Smit David Jankelow Saad Subahi Rob Dyer Erika Dau Ntobeko A. B. Ntusi Source Type: research

Mechanisms of sacubitril–valsartan benefit in HFrEF
Nature Reviews Cardiology, Published online: 19 September 2019; doi:10.1038/s41569-019-0282-2Two studies reveal new details of the mechanisms underlying the benefits of the angiotensin receptor–neprilysin inhibitor sacubitril–valsartan in patients with heart failure and reduced ejection fraction, suggesting that sacubitril–valsartan induces reverse cardiac remodelling but has no effect in reducing central aortic stiffness. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 19, 2019 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Ticagrelor reduces ischaemic risk in patients with CAD and diabetes
Nature Reviews Cardiology, Published online: 19 September 2019; doi:10.1038/s41569-019-0281-3Addition of ticagrelor to the treatment regimen of patients with stable coronary artery disease and diabetes with or without previous percutaneous coronary intervention significantly improved outcomes. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 19, 2019 Category: Cardiology Authors: Karina Huynh Source Type: research

Benefits of COMPLETE revascularization
Nature Reviews Cardiology, Published online: 19 September 2019; doi:10.1038/s41569-019-0283-1In patients with STEMI and multivessel coronary artery disease, a strategy of revascularizing both the culprit lesion and any angiographically significant nonculprit lesions achieves better outcomes than a strategy of revascularizing only the culprit lesion. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 19, 2019 Category: Cardiology Authors: Gregory B. Lim Source Type: research

AI-derived adipose tissue biomarker for risk prediction using CCTA
Nature Reviews Cardiology, Published online: 18 September 2019; doi:10.1038/s41569-019-0278-yA novel machine-learning-derived biomarker that can detect structural changes in perivascular fat improved cardiac risk prediction beyond traditional prediction tools. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 18, 2019 Category: Cardiology Authors: Karina Huynh Source Type: research

Reductions in LDL-cholesterol and blood-pressure levels have cumulative benefits
Nature Reviews Cardiology, Published online: 17 September 2019; doi:10.1038/s41569-019-0279-xLifelong genetic exposure to lower levels of both LDL cholesterol and systolic blood pressure is associated with an independent, additive and dose-dependent decrease in the risk of major coronary events. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 17, 2019 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Clinical algorithm to screen for cardiopulmonary disease in low-income settings
Nature Reviews Cardiology, Published online: 16 September 2019; doi:10.1038/s41569-019-0268-0Africa faces many health challenges, many of which are unique to the continent. Although rarely considered an important contributor to premature death in high-income countries, cardiopulmonary disease (CPD) is, for a number of reasons, a common condition affecting Africans at a young age. In addition to recognizing CPD as an important condition, we outline a pragmatic screening protocol for identifying CPD in the African context. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 16, 2019 Category: Cardiology Authors: Simon Stewart Wael Al-Delaimy Karen Sliwa Magdi Yacoub Ana Mocumbi Source Type: research

Clonal haematopoiesis, aortic stenosis and reduced survival after TAVI
Nature Reviews Cardiology, Published online: 16 September 2019; doi:10.1038/s41569-019-0275-1A new study shows that clonal haematopoiesis of indeterminate potential (CHIP)-driver mutations in DNMT3A or TET2 are associated with increased medium-term mortality in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 16, 2019 Category: Cardiology Authors: Gregory B. Lim Source Type: research

The search for an effective HFpEF treatment continues
Nature Reviews Cardiology, Published online: 16 September 2019; doi:10.1038/s41569-019-0277-zThe PARAGON-HF trial indicates that sacubitril–valsartan does not have a significant benefit in patients with heart failure with preserved ejection fraction (HFpEF) for reducing hospitalizations for heart failure and death from cardiovascular causes. However, the trial suggests a potential benefit in patients with low left ventricular ejection fraction and in women. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 16, 2019 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Reduced bleeding with genotype-guided antiplatelet therapy
Nature Reviews Cardiology, Published online: 16 September 2019; doi:10.1038/s41569-019-0276-0Genotype-guided selection of oral P2Y12 inhibitor therapy (clopidogrel versus prasugrel or ticagrelor) can reduce the incidence of bleeding in patients who have undergone primary percutaneous coronary intervention. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 16, 2019 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Still no benefit of MitraClip in MITRA-FR
Nature Reviews Cardiology, Published online: 16 September 2019; doi:10.1038/s41569-019-0280-4The 2-year results of the MITRA-FR trial confirm the 1-year findings showing that addition of percutaneous mitral valve repair to medical treatment does not reduce the risk of death or hospitalization for heart failure compared with medical treatment alone in patients with heart failure and severe secondary mitral regurgitation (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 16, 2019 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Expanding the indications for transcatheter aortic valve implantation
Nature Reviews Cardiology, Published online: 16 September 2019; doi:10.1038/s41569-019-0254-6This Review discusses the evolving indications of transcatheter aortic valve implantation (TAVI), including the latest clinical trials in young and low-risk patients with symptomatic severe aortic stenosis and ongoing studies exploring TAVI for other indications, including severe bicuspid aortic valve stenosis and pure native aortic regurgitation, highlighting procedural implications and caveats of new and future indications. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 16, 2019 Category: Cardiology Authors: Zouhair Rahhab Nahid El Faquir Didier Tchetche Victoria Delgado Susheel Kodali E. Mara Vollema Jeroen Bax Martin B. Leon Nicolas M. Van Mieghem Source Type: research

Genetics of rheumatic fever and rheumatic heart disease
Nature Reviews Cardiology, Published online: 13 September 2019; doi:10.1038/s41569-019-0258-2Rheumatic heart disease is a complication of group A streptococcal infection and rheumatic fever. In this Review, Muhamed and colleagues assess the emerging role of genome-wide association studies in detecting loci associated with genetic susceptibility to rheumatic heart disease. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 13, 2019 Category: Cardiology Authors: Babu Muhamed Tom Parks Karen Sliwa Source Type: research

Community-based plan lowers CVD risk
Nature Reviews Cardiology, Published online: 13 September 2019; doi:10.1038/s41569-019-0274-2A novel, community-based model of care led by non-physician health workers significantly reduced blood pressure levels and risk of cardiovascular disease. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 13, 2019 Category: Cardiology Authors: Karina Huynh Source Type: research

Prasugrel superior to ticagrelor in ACS
Nature Reviews Cardiology, Published online: 11 September 2019; doi:10.1038/s41569-019-0270-6Prasugrel superior to ticagrelor in ACS (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 11, 2019 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Edoxaban noninferior to VKA in AF after PCI
Nature Reviews Cardiology, Published online: 11 September 2019; doi:10.1038/s41569-019-0272-4Edoxaban noninferior to VKA in AF after PCI (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 11, 2019 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Rivaroxaban monotherapy for AF and stable CAD
Nature Reviews Cardiology, Published online: 11 September 2019; doi:10.1038/s41569-019-0271-5Rivaroxaban monotherapy for AF and stable CAD (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 11, 2019 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research

Use of polypills for CVD prevention
Nature Reviews Cardiology, Published online: 06 September 2019; doi:10.1038/s41569-019-0267-1In the PolyIran study, a fixed-dose polypill strategy was more effective than non-pharmacological interventions in reducing the risk of cardiovascular events. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 6, 2019 Category: Cardiology Authors: Karina Huynh Source Type: research

Serelaxin treatment does not reduce incidence of death in patients with AHF
Nature Reviews Cardiology, Published online: 02 September 2019; doi:10.1038/s41569-019-0264-4In patients with acute heart failure, treatment with serelaxin, a recombinant form of human relaxin 2, did not reduce the incidence of cardiovascular death or worsening heart failure. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - September 2, 2019 Category: Cardiology Authors: Karina Huynh Source Type: research

Reply to ‘Relationship between stent fracture and thrombosis’
Nature Reviews Cardiology, Published online: 29 August 2019; doi:10.1038/s41569-019-0263-5Reply to ‘Relationship between stent fracture and thrombosis’ (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - August 29, 2019 Category: Cardiology Authors: Tommaso Gori Alberto Polimeni Ciro Indolfi Lorenz R äber Tom Adriaenssens Thomas M ünzel Source Type: research

Relationship between stent fracture and stent thrombosis
Nature Reviews Cardiology, Published online: 29 August 2019; doi:10.1038/s41569-019-0262-6Relationship between stent fracture and stent thrombosis (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - August 29, 2019 Category: Cardiology Authors: Yue-Hua Ruan Ren-Qiang Yang Source Type: research

Saphenous vein grafts in contemporary coronary artery bypass graft surgery
Nature Reviews Cardiology, Published online: 27 August 2019; doi:10.1038/s41569-019-0249-3Although saphenous vein grafts (SVGs) are the most commonly used conduit in coronary artery bypass graft surgery, vein graft failure (VGF) occurs in almost half of all patients with SVGs by 10 years after surgery. In this Review, Caliskan and colleagues discuss approaches to prevent saphenous VGF, including optimal harvesting techniques and intraoperative preservation strategies. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - August 27, 2019 Category: Cardiology Authors: Etem Caliskan Domingos Ramos de Souza Andreas B öning Oliver J. Liakopoulos Yeong-Hoon Choi John Pepper C. Michael Gibson Louis P. Perrault Randall K. Wolf Ki-Bong Kim Maximilian Y. Emmert Source Type: research

Resolution of thrombus burden by targeting inflammatory mediators to treat DVT
Nature Reviews Cardiology, Published online: 21 August 2019; doi:10.1038/s41569-019-0259-1Treatment with resolvin D4, a specialized pro-resolving mediator, significantly attenuated thrombus burden in a mouse model of deep vein thrombosis. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - August 21, 2019 Category: Cardiology Authors: Karina Huynh Source Type: research

Counter-regulatory renin–angiotensin system in cardiovascular disease
Nature Reviews Cardiology, Published online: 19 August 2019; doi:10.1038/s41569-019-0244-8The non-canonical axis of the renin–angiotensin system (RAS) has an important role in cardiovascular physiology and disease. In this Review, Ocaranza and colleagues discuss the interplay between components of the counter-regulatory RAS and the therapeutic potential of targeting this system to treat cardiovascular disease. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - August 19, 2019 Category: Cardiology Authors: Maria Paz Ocaranza Jaime A. Riquelme Lorena Garc ía Jorge E. Jalil Mario Chiong Robson A. S. Santos Sergio Lavandero Source Type: research

Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease
Nature Reviews Cardiology, Published online: 12 August 2019; doi:10.1038/s41569-019-0247-5Clonal haematopoiesis of indeterminate potential (CHIP) commonly occurs as a result of mutations in transcriptional regulators and is associated with a doubling of the risk of atherosclerotic cardiovascular disease. Jaiswal and Libby propose that CHIP contributes to the increased inflammation seen in ageing and thereby explains some of the age-related risk of cardiovascular disease. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - August 12, 2019 Category: Cardiology Authors: Siddhartha Jaiswal Peter Libby Source Type: research

Molecular genetic framework underlying pulmonary arterial hypertension
Nature Reviews Cardiology, Published online: 12 August 2019; doi:10.1038/s41569-019-0242-xPulmonary arterial hypertension (PAH) is characterized by right ventricular hypertrophy and the absence of underlying cardiac or pulmonary disease. In this Review, Southgate and colleagues discuss the latest advances in the identification of genetic variants underlying PAH development and progression. (Source: Nature Reviews Cardiology)
Source: Nature Reviews Cardiology - August 12, 2019 Category: Cardiology Authors: Laura Southgate Rajiv D. Machado Stefan Gr äf Nicholas W. Morrell Source Type: research