Study reveals steep cost of delaying stroke treatment
Researchers from Canada have found that delaying treatment for stroke patients...Read more on AuntMinnie.comRelated Reading: 3 CTA signs show which stroke patients can skip surgery Perfusion imaging expands window for stroke treatment Infervision debuts AI stroke screening software CTA helps direct use of clot removal for stroke patients Color mapping boosts vessel interpretation in stroke CT (Source: Headlines)
Source: Headlines - October 18, 2018 Category: Radiology Source Type: news

Variabilities in the Use of IV Epinephrine in the Management of Cardiac Arrest Patients
Animal studies in the 1960s first demonstrated the benefits of using epinephrine alongside external compressions and external shock to achieve return of spontaneous circulation (ROSC) in arrested and asphyxiated dogs.1–4 Since then, epinephrine has become integral to the performance of advanced cardiac life support (ACLS) care. The American Heart Association’s (AHA) recommendations in the Emergency Cardiovascular Care (ECC) Guidelines are that a standard dose of 1 mg of 1:10,000 epinephrine every 3–5 minutes “may be reasonable for patients with cardiac arrest.”5 No maximum total dose is delineated, and 1 mg every...
Source: JEMS Patient Care - October 15, 2018 Category: Emergency Medicine Authors: Nidhish Lokesh, NREMT Tags: Exclusive Articles Cardiac & Resuscitation Source Type: news

Variabilities in the Use of IV Epinephrine in the Management of Cardiac Arrest Patients
Discussion The results show a lack of standardization in epinephrine dosing across large EMS systems around the world, in spite of the existence of standard guidelines such as the 2015 AHA CPR and ECC Guidelines.5 Dosing maximums, epinephrine drip use, dosing amount and frequency, and dosing distinction for rhythms not being more consistent across the board shows the current state of uncertainty that epinephrine administration is in at this time. The AHA ECC Guidelines don’t specify dosing maximums or about distinguish between v fib and other rhythms.5 In those two categories, responding agencies showed a lack of standar...
Source: JEMS Special Topics - October 15, 2018 Category: Emergency Medicine Authors: Nidhish Lokesh, NREMT Tags: Exclusive Articles Cardiac & Resuscitation Source Type: news

Neuromics New Neuronal Markers
Best of the BestWe are recognized for having some of the bestNeuronal-Glial Antibodies in the business. We are pleased to announce the addition of these:CH22122– Tyrosine HydroxylaseGT22101 - GFPGT22102– MAP2GT22103 - VimentinMO22186– Tyrosine HydroxylaseRA22135– Tyrosine HydroxylaseImmunofluorescent analysis of rat brainstem section stained withGT22102, MAP2dilution 1:2,000 in red, and costained with mouse mAb to MO22121, MBP dilution 1:5,000, in green. Following transcardial perfusion of rat with 4% paraformaldehyde, brain was postfixed for 24 hours, cut to 45 μM, and free-floating sections were stained with the...
Source: Neuromics - October 7, 2018 Category: Neuroscience Tags: Immunofluorescence MAP2 antibody MBP Antibody Myelin Basic Protein TH antibody Tyrosine Hydroxlase antibody Western Blotting Source Type: news

NeoVasc shares jump on 12-week Reducer data
Neovasc (NSDQ:NVCN) today saw shares jump after it released 12-week data from the first patient implanted with its Reducer device designed for treating refractory angina. The Reducer system is designed to alter blood flow in the heart’s circulatory system to increase perfusion of oxygenated blood to ischemic areas of heart muscle, and can be placed in a minimally invasive transvenous procedure, the Vancouver-based company said. The patient, implanted with the device in June as part of a compassionate use case, reported the ability to walk several miles without symptoms after having not been able to walk two blocks befor...
Source: Mass Device - October 3, 2018 Category: Medical Devices Authors: Fink Densford Tags: Cardiovascular Neovasc Inc. Source Type: news

The LKB1-AMPK-{alpha}1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria
Hypoxic pulmonary vasoconstriction (HPV), which aids ventilation-perfusion matching in the lungs, is triggered by mechanisms intrinsic to pulmonary arterial smooth muscles. The unique sensitivity of these muscles to hypoxia is conferred by mitochondrial cytochrome c oxidase subunit 4 isoform 2, the inhibition of which has been proposed to trigger HPV through increased generation of mitochondrial reactive oxygen species. Contrary to this model, we have shown that the LKB1–AMPK-α1 signaling pathway is critical to HPV. Spectral Doppler ultrasound revealed that deletion of the AMPK-α1 catalytic subunit blocke...
Source: Signal Transduction Knowledge Environment - October 2, 2018 Category: Science Authors: Moral-Sanz, J., Lewis, S. A., MacMillan, S., Ross, F. A., Thomson, A., Viollet, B., Foretz, M., Moran, C., Hardie, D. G., Evans, A. M. Tags: STKE Research Articles Source Type: news

Airway, Breathing or Consequences: Use Your Tools and Trust the Technology
Conclusion Ongoing confirmation of proper placement of an airway device is critical. Whether by a colorimetric device, capnometry, or, ideally, capnography, the tools should always be available and always be used. Note that there’s no mention of when this confirmation should take place. That’s because it’s essential to ensure that the tube is in the right spot and stays in the right spot. Each time, every time, all the time! As a healthcare provider, it’s essential to know your equipment, its uses and its limitations. You’re responsible for understanding not only how and why these tools work, but also how and why...
Source: JEMS Special Topics - October 1, 2018 Category: Emergency Medicine Authors: Scott DeBoer, RN, MSN, CEN, CPEN, CCRN, CFRN, EMT-P Tags: Airway & Respiratory Exclusive Articles Source Type: news

What is the Blood Culture Recovery Rate After Antibiotic Pretreatment?
Discussion Sepsis is an inflammatory response syndrome in the presence of an infection, it can be caused by bacteria, viruses or fungi. Bacteremia is the presence of bacteria in the blood. Studies from the US show an increased incidence of sepsis (0.56 to 0.89 cases/1000 children in all age groups) but a decreased fatality rate from 10.3% to 8.9%. The prevalence of severe sepsis in pediatric intensive care settings is reported in as many as 7.7% of admissions. Severe sepsis is more common when patients have co-morbities. Primary prevention includes immunization and appropriate precautions and procedures (i.e. catheter acce...
Source: - October 1, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Using Imaging to Select for Late Window Endovascular Therapy Using Imaging to Select for Late Window Endovascular Therapy
After acute stroke, MRI and computed tomography perfusion may be useful for selecting appropriate candidates for late window thrombectomy.Stroke (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 24, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

A Change of Heart: Perspectives on Patient Care and Technology
Bryon Moore has had a rich and varied career in EMS. He became an EMT in 1979 and received paramedic training at the fabled UCLA Daniel Freeman School for Paramedicine in 1982. He went on to be a paramedic in several systems before becoming the Northern California Clinical Coordinator for American Medical Response (AMR). Bryon then was attracted to helping develop and bring new resuscitation technology to market, working for a variety of medical device companies and launching new products globally. He’s currently VP of EMS Market Development for Defibtech, a company owned by Nihon Kohden, a leading medical device ma...
Source: JEMS Special Topics - September 19, 2018 Category: Emergency Medicine Authors: JEMS Staff Tags: EMS Insider Exclusive Articles Administration and Leadership Source Type: news

3 CTA signs show which stroke patients can skip surgery
There are three key characteristics evident on CT angiography (CTA) scans that...Read more on AuntMinnie.comRelated Reading: 5 risk factors help predict brain hemorrhage on CT AI algorithm can triage head CT exams for urgent review Perfusion imaging expands window for stroke treatment CTA helps direct use of clot removal for stroke patients Color mapping boosts vessel interpretation in stroke CT (Source: Headlines)
Source: Headlines - September 13, 2018 Category: Radiology Source Type: news

Cerebral hemodynamics after transcranial direct current stimulation (tDCS) in patients with consequences of traumatic brain injury - Trofimov AO, Kalentiev G, Karelsky M, Ksenofontova C, Ruzavina A, Yuriev M, Bragin DE.
In recent years, hopes for better treatment of traumatic brain injury (TBI) have focused on non-pharmacologic transcranial electrical brain stimulation; however, studies of perfusion changes after stimulation are few and contradictory. Therefore, the aim o... (Source: SafetyLit)
Source: SafetyLit - September 6, 2018 Category: International Medicine & Public Health Tags: TBI Source Type: news

Miracor Medical closes $35m Series D
Miracor Medical Systems said today it raised $34.6 million (EU €30 million) Series D round of financing to help support the development and commercialization of its PiCSO Impulse System. The round was led by Ming Capital and co-led by a strategic investor, the Belgium-based company said. The round was also joined by newly invested Belgian investment fund Quest for Growth and existing investors Ming Capital, SFPI and Meusinvest. The company’s PiCSO therapy is designed to be used during stenting procedures for patients affected by acute myocardial infarcts to improve pressure in the coronary venous system to improve micr...
Source: Mass Device - September 4, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Cardiovascular Funding Roundup Miracor Source Type: news

Philips acquires pulse oximetry sensor maker Xhale Assurance
Royal Philips (NYSE:PHG) said this week it acquired pulse oximetry sensor maker Xhale Assurance for an undisclosed amount. Xhale Assurance produces a disposable pulse oximetry sensor designed to be placed on the wing of the nose to monitor heart rate and blood oxygenation under low perfusion conditions, which Amsterdam-based Philips said can be challenging with conventional fingertip sensors. Philips said that the acquisition will differentiate its existing oxygen saturation monitoring solutions protfolio and allow it to expand into an underserved clinical segment. “Xhale Assurance’s nasal alar sensor offers excep...
Source: Mass Device - August 31, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Diagnostics Mergers & Acquisitions royalphilips Source Type: news

CT finds heart disease in patients with lung cancer
Assessing coronary artery disease on the CT scans of patients with lung cancer...Read more on AuntMinnie.comRelated Reading: AI, new cardiac imaging technology can assess for CAD CCTA biomarker spots high-risk plaques in heart disease Cardiac hybrid imaging predicts adverse cardiac events CCTA reduces unnecessary invasive coronary procedures Is CT or MR perfusion better for diagnosing CAD? (Source: Headlines)
Source: Headlines - August 27, 2018 Category: Radiology Source Type: news