New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis

SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely active UC relative to outcomes associated with second- or third-line use (P0540).1 Additionally, in a separate real-world claims analysis, a greater proportion of bio-naïve patients who started biologic therapy with STELARA (n=948) for moderately to severely active CD showed persistence at 12 months versus adalimumab (n=4,143) (P0525).2 These data are among 16 abstracts, including one oral presentation, presented at the 2021 American College of Gastroenterology Annual Scientific Meeting, which is taking place October 22-27 in Las Vegas, Nevada.1,2“Data emerging from these analyses inform physicians with additional evidence to support STELARA as a first-line option for patients with moderately to severely active Crohn’s disease and ulcerative colitis,” said Christopher Gasink, M.D., Head of Immunology Medical Affairs, Gastroen...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news

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I have been told the following by my asc. Anyone else ever come across this? “27096 is not reimbursed by Medicare when performed in an ASC. G0260 replaces 27096”
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
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Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Background The extent to which cognitive function differs between patients who receive implantable cardioverter-defibrillator (ICD) therapy and patients with heart failure (HF) who do not receive ICD therapy remains to be elucidated. Objectives The aim of this study was to compare the cognitive function between patients with primary or secondary ICDs and patients with HF without an ICD. Methods This descriptive, comparative study included 116 patients who received ICDs and 74 patients with HF who did not receive ICDs. Patients underwent neuropsychological assessment for general cognition, memory, and exec...
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Background Cognitive impairment is prevalent in heart failure and is associated with higher mortality rates. The mechanism behind cognitive impairment in heart failure with preserved ejection fraction (HFpEF) has not been established. Objective The aim of this study was to evaluate associations between abnormal cardiac hemodynamics and cognitive impairment in individuals with HFpEF. Methods A secondary analysis of Atherosclerosis Risk in Communities (Atherosclerosis Risk in Communities) study data was performed. Participants free of stroke or dementia who completed in-person assessments at visit 5 were in...
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Conclusions Implantation of an LVAD is associated with significant, nonlinear improvement in short-term memory and global cognitive function, with the most significant improvements occurring in the first 3 months after implantation. Clinicians should anticipate improvements in cognitive function after LVAD implantation and modify postimplantation education to maximize effectiveness of LVAD self-care.
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Conclusion This study stresses the importance for healthcare professionals to identify SSD and prevent its progression to delirium.
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Background Health literacy has predicted mortality in heart failure. However, the role of cognitive functioning in this relationship has not been evaluated. We hypothesized that health literacy would predict all-cause mortality but that cognitive functioning would modify the relationship between health literacy and mortality in heart failure. Objective The aim of this study was to examine the association between health literacy, cognitive functioning, and mortality in patients with heart failure. Methods This secondary analysis of a larger study included 298 patients with heart failure with reduced ejecti...
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Cognitive Function in Heart Failure Source Type: research
Conclusions Genomics will continue to drive advances in CVD prevention and management, and equitable progress is imperative. Nursing should leverage the public's trust and its widespread presence in clinical and community settings to prevent the worsening of CVD disparities among African Americans.
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Precision Health in Cardiovascular Conditions Source Type: research
Background Cardiovascular disease is a significant health problem in the United States, attributed to more than 30% of all deaths annually. Anxiety has been associated with cardiovascular disease risk and is thought to be associated with cardiovascular disease risk through inflammatory pathways. Objective The purposes of this study were to examine the relationship between anxiety and systemic inflammation in individuals at risk for cardiovascular disease and to determine if single-nucleotide polymorphisms (SNPs) associated with inflammation moderate this relationship. Methods A secondary analysis was cond...
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Precision Health in Cardiovascular Conditions Source Type: research
Conclusion By identifying classes of biomarkers, providers may be better able to identify patients who are at risk of progressing into advanced HF quicker or those who are more likely to have more severe complications, such as fluid overload or renal disease.
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: ARTICLES: Precision Health in Cardiovascular Conditions Source Type: research
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