Researchers uncover early results about an existing tuberculosis vaccine that has been hypothesized to help against the coronavirus
While scientists race to develop and test a vaccine effective against SARS-CoV-2, the virus that causes COVID-19, recent studies have indicated that countries with widespread BCG vaccination appear to be weathering the pandemic better than their counterparts. This has led many researchers to suspect that BCG vaccine, which immunizes against tuberculosis, might offer protection against COVID-19. (Source: World Pharma News)
Source: World Pharma News - September 21, 2020 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Vaccination insights
(University of California - Santa Barbara) While scientists race to develop and test a vaccine effective against SARS-CoV-2, the virus that causes COVID-19, recent studies have indicated that countries with widespread BCG vaccination appear to be weathering the pandemic better than their counterparts. This has led many researchers to suspect that BCG vaccine, which immunizes against tuberculosis, might offer protection against COVID-19. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 21, 2020 Category: Infectious Diseases Source Type: news

BCG vaccine safe for elderly, can protect against respiratory infections: Study
However the study, published in the journal Cell, cautioned that it is unclear whether the vaccine can prevent COVID-19 in the older sections of the population. (Source: The Economic Times)
Source: The Economic Times - September 3, 2020 Category: Consumer Health News Source Type: news

Elderly people protected against respiratory infections by BCG vaccine
(Radboud University Medical Center) The BCG vaccine has a broad, stimulating effect on the immune system. This gives it an effective preventive action against various infections - possibly also against COVID-19. New studies are investigating that. BCG is frequently given to children, but a double-blind randomized clinical study, a collaboration between Radboud university medical center and the National and Kapodistrian University of Athens shows that elderly people also benefit from it. The results are published in Cell. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 1, 2020 Category: Biology Source Type: news

TB vaccine shows encouraging results against coronavirus in phase-3 clinical trials
VPM1002, a tuberculosis vaccine, is showing encouraging results against the coronavirus infection in phase-III clinical trials being conducted in Germany. (Source: The Economic Times)
Source: The Economic Times - August 13, 2020 Category: Consumer Health News Source Type: news

Significantly improved COVID-19 outcomes in countries with higher TB vaccination coverage
(American Associates, Ben-Gurion University of the Negev) The researchers discovered that BCG regimes are associated with better COVID-19 outcomes, both in reducing infection rates and death rates per million, especially for ages 24 or younger who had received the vaccination in the last 15 years. There was no effect among older adults who had received the BCG vaccine. Many countries have stopped inoculating their entire population, but some still use BCG widely. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - August 12, 2020 Category: Infectious Diseases Source Type: news

BCG shots could slow down Covid-19 spread in first thirty days, says study
The paper published in Science Advances, a peer-reviewed medical journal brought out by the American Association for the Advancement of Science, said that countries with mandatory Bacillus Calmette-Gu érin (BCG) vaccination showed “slower infection and death rates” during the first 30 days of the Covid-19 outbreak in their country. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - August 2, 2020 Category: Pharmaceuticals Source Type: news

Mandatory country-wide BCG vaccination found to correlate with slower growth rates of COVID-19 cases
(American Association for the Advancement of Science) Scientists have found that countries with mandatory Bacillus Calmette-Gu é rin (BCG) vaccination until at least the year 2000 tended to exhibit slower infection and death rates during the first 30 days of the outbreak (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 31, 2020 Category: Infectious Diseases Source Type: news

Serum Institute conducting phase III clinical trial of tuberculosis vaccine: DBT
The BCG vaccine is administered routinely to all newborns as part of the national childhood immunisation programme to prevent tuberculosis (TB), an infection caused by bacteria that mainly affects the lungs. It has beneficial heterologous effects and proven antiviral and immune modulatory properties that protect against infectious diseases through induction of trained innate immunity and heterologous adaptive immunity. (Source: The Economic Times)
Source: The Economic Times - July 27, 2020 Category: Consumer Health News Source Type: news

Notes from the Field: Effects of the COVID-19 Response on Tuberculosis Prevention and Control Efforts - United States, March-April 2020
This report describes the importance of continuing to provide resources for tuberculosis testing during the COVID-19 pandemic. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - July 23, 2020 Category: American Health Tags: Coronavirus [CoV] MMWR Morbidity & Mortality Weekly Report Tuberculosis (TB) Tuberculosis Vaccine (BCG) COVID-19 Coronavirus Disease 2019 Source Type: news

Bovine TB vaccine trials get go-ahead in England and Wales
Scientific breakthrough could lead to phasing out of badger culling to tackle diseaseField trials of a cattle vaccine for bovine tuberculosis have been given the go-ahead as part of moves to phase out badger culling to tackle the disease.The trials are due to get under way in England and Wales to accelerate deployment of a cattle vaccine for TB by 2025, the government announced on Wednesday.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - July 22, 2020 Category: Science Authors: PA Media Tags: Bovine tuberculosis Animal welfare Animals Environment Farming Rural affairs UK news Badgers Science Source Type: news

BCG vaccine being tried for Covid-19 elderly individuals in hotspots in India
The study sponsored by the ICMR will recruit 1,450 elderly individuals within the ages of 60 and 99 with no preexisting conditions such as diabetes and will run across six centers in India. The hypothesis for the BCG vaccine comes from studies that have shown that the vaccine — besides protecting children against tuberculosis — also has non-specific effects against other respiratory tract infections. (Source: The Economic Times)
Source: The Economic Times - July 16, 2020 Category: Consumer Health News Source Type: news

TN to launch trial to study efficacy of BCG vaccine to reduce COVID-19 mortality for elders
This is significant as the study will see whether the vaccine ’s potential to combat Covid-19 and prevent hospitalisation among the aged as they are more susceptible to picking up the infection as they often suffer from co-morbid conditions. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - July 15, 2020 Category: Pharmaceuticals Source Type: news

Evidence Shows TB Vaccine May Help Versus COVID-19
Developing countries have lower-than-expected COVID-19 death rates, and a TB vaccine given in countries with high rates of tuberculosis might play a significant role in reducing COVID-19 death rates. (Source: WebMD Health)
Source: WebMD Health - July 13, 2020 Category: Consumer Health News Source Type: news

Evidence Mounts That TB Vaccine Might Help Protect Against COVID-19
MONDAY, July 13, 2020 -- A tuberculosis vaccine may help reduce the risk of death from COVID-19, researchers suggest. Developing countries have lower-than-expected COVID-19 death rates, and a TB vaccine given in countries with high rates of... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 13, 2020 Category: General Medicine Source Type: news

More evidence emerges that a TB vaccine might help fight coronavirus
More research emerged this week in potential support of using the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) as a tool in the fight against coronavirus. (Source: CNN.com - Health)
Source: CNN.com - Health - July 10, 2020 Category: Consumer Health News Source Type: news

Preliminary study suggests tuberculosis vaccine may be limiting COVID-19 deaths
(Virginia Tech) While a direct correlation between BCG vaccinations and a reduction in coronavirus mortalities still needs to be understood more fully, researchers hold hope that the BCG vaccine might be able to provide at least short-term protections against severe COVID-19, particularly for front-line medical workers or high-risk patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 8, 2020 Category: International Medicine & Public Health Source Type: news

Janssen Announces Discontinuation of Phase 3 LOTUS Study Evaluating Ustekinumab in Systemic Lupus Erythematosus
SPRING HOUSE, PENNSYLVANIA, June 26, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today its decision to discontinue the Phase 3 LOTUS study of STELARA® (ustekinumab) in Systemic Lupus Erythematosus (SLE) due to lack of efficacy in SLE.The decision is based on data from a pre-planned interim efficacy analysis. Interim safety findings were consistent with the known safety profile of STELARA, and no new safety signals were identified. Investigators, study participants and health authorities have been informed of the decision. The company intends to thoroughly analyze the totality of...
Source: Johnson and Johnson - June 26, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

South Africa: New Multi-Functional TB Blood Test Validated
[UCT] Researchers from the South African Tuberculosis Vaccine Initiative (SATVI) at the University of Cape Town (UCT), the Center for Global Infectious Disease Research - Seattle in the United States, and a large consortium of collaborators have developed a validated a new, simple blood-based test that has the potential to serve multiple functions in the fight against TB. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - May 25, 2020 Category: Infectious Diseases Source Type: news

A Vaccine Against COVID-19 Would Be the Latest Success in a Long Scientific History
Here’s betting you wouldn’t want anyone blowing smallpox scabs up your nose. But you might feel differently if you lived in 15th century China. Long ago, the Chinese recognized that people who had contracted smallpox once were immune to reinfection. They came up with the idea of preserving scabs from individuals who had suffered mild cases, drying them out, crushing them to a powder and blowing them up the nostril. For boys it was the right nostril, for girls it was the left because, well, 15th century. That is how the story of vaccines usually begins, though that version is decidedly incomplete. For one thing,...
Source: TIME: Science - May 15, 2020 Category: Science Authors: Jeffrey Kluger Tags: Uncategorized COVID-19 Explainer health Source Type: news

Africa: Could BCG, a 100-Year-Old Vaccine for Tuberculosis, Protect Against Coronavirus?
[IPS] This week, the Bill and Melinda Gates Foundation announced it will donate A$10 million to help fund an Australian trial testing whether a very old vaccine, BCG, can be used against a new threat, COVID-19. So what is the BCG vaccine and what might its place be in the fight against coronavirus? (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - May 15, 2020 Category: Infectious Diseases Source Type: news

Could BCG, a 100-year-old Vaccine for Tuberculosis, Protect Against Coronavirus?
This article is republished from The Conversation under a Creative Commons license. Read the original article. The post Could BCG, a 100-year-old Vaccine for Tuberculosis, Protect Against Coronavirus? appeared first on Inter Press Service. (Source: IPS Inter Press Service - Health)
Source: IPS Inter Press Service - Health - May 14, 2020 Category: International Medicine & Public Health Authors: External Source Tags: Global Headlines Health Source Type: news

Mandatory BCG vaccination may make COVID-19 less virulent in India, suggests study
The bacille Calmette-Gurin (BCG) vaccine has a documented protective effect against meningitis and disseminated TB in children, according to the World Health Organisation. It is part of the mandatory childhood immunization programme in many countries including India. (Source: The Economic Times)
Source: The Economic Times - May 8, 2020 Category: Consumer Health News Source Type: news

Researchers unlock TB vaccine puzzle in findings that could save millions of newborns
(University of British Columbia) An international research team has identified the mechanism behind one of science's most enduring mysteries: what makes the 100-year-old tuberculosis (TB) vaccine so effective at preventing newborn deaths from diseases other than TB? (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 6, 2020 Category: Infectious Diseases Source Type: news

An Old TB Vaccine Finds New Life in Coronavirus Trials
Studies are underway to test whether giving a shot of BCG vaccine could protect doctors and nurses against COVID-19. (Source: The Scientist)
Source: The Scientist - May 4, 2020 Category: Science Tags: News & Opinion Source Type: news

A $10 million grant enables BCG vaccine trial to expand internationally, enroll 10,000 healthcare workers
(Murdoch Childrens Research Institute) An A$10 million grant from the Bill& Melinda Gates Foundation will allow the Murdoch Children's Research Institute's (MCRI) clinical trial of the BCG vaccine against COVID-19 to extend to 10,000 healthcare workers across Australia, Spain and The Netherlands. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 4, 2020 Category: Infectious Diseases Source Type: news

Covid-19: What has the BCG vaccine got to do with it? - podcast
Sarah Boseley talks toProf Helen McShane about why there has been interest in the tuberculosis vaccine and whether it could play a role in protecting us against Covid-19Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - April 30, 2020 Category: Science Authors: Presented by Sarah Boseley and produced by Madeleine Finlay Tags: Science Biology Tuberculosis Microbiology Vaccines and immunisation Coronavirus outbreak Infectious diseases Health Medical research Source Type: news

Covid-19: What has the BCG vaccine got to do with it? – Science Weekly Podcast
Sarah Boseley talks toProf Helen McShane about why there has been interest in the tuberculosis vaccine and whether it could play a role in protecting us against Covid-19Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - April 30, 2020 Category: Science Authors: Presented by Sarah Boseley and produced by Madeleine Finlay Tags: Science Biology Tuberculosis Microbiology Vaccines and immunisation Coronavirus outbreak Infectious diseases Health Medical research Source Type: news

Maharashtra plans clinical trials of TB vaccine BCG to treat Covid-19
The 121-year-old institute ’s trial is intended for patients who are moderately ill with Covid-19 and is likely to be carried out in small batches. (Source: The Economic Times)
Source: The Economic Times - April 30, 2020 Category: Consumer Health News Source Type: news

Does BCG vaccination protect against acute respiratory infections and COVID-19? A rapid review of current evidence, CEBM
There is systematic review evidence with low to moderate risk of bias that BCG vaccination prevents respiratory infections (pneumonia and influenza) in children and the elderly. These non-specific effects are mediated by induction of innate immune memory (trained immunity).There is a lack of evidence that BCG vaccine protects against COVID-19. Currently, two clinical trials are ongoing to determine if BCG vaccination protects healthcare workers during the COVID-19 pandemic. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 27, 2020 Category: Consumer Health News Source Type: news

BCG Vaccine Fighting Coronavirus in South Asia
The map from the medical journal Plos Medicine displays BCG vaccination policy by country. Bacillus Calmette-Guérin vaccine is a vaccine primarily used against tuberculosis. Yellow: The country now has a universal BCG vaccination program. Blue: The country used to recommend BCG vaccination for everyone, but now does not. Red: The country never had a universal vaccination program.By Darini Rajasingham-SenanayakeCOLOMBO, Sri Lanka, Apr 20 2020 (IPS) Numerous studies in many parts of the world have linked the BCG (Bacillus Calmette-Guerin) vaccination, widely used in the developing world with fewer Coronavirus cases. T...
Source: IPS Inter Press Service - Health - April 20, 2020 Category: International Medicine & Public Health Authors: Darini Rajasingham-Senanayake Tags: Development & Aid Economy & Trade Featured Global Headlines Health TerraViva United Nations Source Type: news

Africa: Statement of Africa CDC on Potential Clinical Trial of a Tuberculosis Vaccine Protective Against COVID-19
[Africa CDC] The Africa Centres for Disease Control and Prevention (Africa CDC) strongly condemns the very disgusting comments made by Professors Jean-Paul Mira and Camille Locht on French Television on using Africans for testing a tuberculosis vaccine in clinical trials to see if it is protective against COVID-19. These racist and condescending comments must be condemned by all decent human beings. Indeed, COVID-19 is a global humanitarian crisis that requires global actions and global solidarity. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - April 17, 2020 Category: Infectious Diseases Source Type: news

Tuberculosis vaccine could be a weapon against coronavirus
Researchers in at least four countries are testing whether the century-old vaccine for tuberculosis can lessen the severity of some COVID-19 cases. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - April 17, 2020 Category: Consumer Health News Source Type: news

Australian study tests tuberculosis vaccine against coronavirus
A century-old vaccine used to treat tuberculosis, known as the BCG vaccine, is showing promise in treating coronavirus symptoms. In CBS News' latest installment of "Racing to a Cure," researchers say it might also lessen the severity of coronavirus by boosting the body's ability to fight off the infection before it gets worse. Debora Patta reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - April 17, 2020 Category: Consumer Health News Source Type: news

BCG vaccine not recommended for virus: WHO
The statement gains significance for countries including India, where some states are considering using the BCG vaccine for clinical trials on Covid-19 patients. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 15, 2020 Category: Pharmaceuticals Source Type: news

Bacille Calmette-Gu érin (BCG) Vaccination and COVID-19
This report describes why, in the absence of evidence, the World Health Organization (WHO) does not recommend Bacille Calmette-Guerin (BCG) vaccination for the prevention of COVID-19. WHO continues to recommend neonatal BCG vaccination in countries or settings with a high incidence of tuberculosis. (Text) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - April 12, 2020 Category: International Medicine & Public Health Source Type: news

Coronavirus Fight: A 100-Year-Old Tuberculosis Vaccine Could Help Combat COVID-19
(CNN) — As researchers scramble to find new drugs and vaccines for the coronavirus, a vaccine that is more than a century old has piqued researchers’ interests. The Bacillus Calmette-Guerin vaccine — which was first developed to fight off tuberculosis — is being studied in clinical trials around the world as a way to fight the novel coronavirus. Tuberculosis and COVID-19 infection are two very different diseases — TB is caused by a type of bacteria while COVID-19 is caused by a virus, for starters. But the BCG vaccine might help people build immune responses to things other than TB, causing &l...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - April 12, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Syndicated CBSN Boston Syndicated Local CNN Coronavirus Health News Massachusetts General Hospital Source Type: news

View: The ‘Covid-19 vaccine’ buzz should silence the anti-vaccination lobbies
The western societies which had led the smear campaign are those turning most fervently to the same labs for deliverance. Hope has taken the shape of an 82-year-old TB vaccine, BCG (Bacillus Calmette –Guérin) –whose effectiveness in its primary role happens to be iffy. (Source: The Economic Times)
Source: The Economic Times - April 12, 2020 Category: Consumer Health News Source Type: news

Studies using TB vaccine against COVID-19 underway, but shot months away
Researchers this week began experimenting with use of a tuberculosis vaccine in the fight against COVID-19, the disease caused by the new coronavirus, but a viable shot is still likely months away. (Source: Health News - UPI.com)
Source: Health News - UPI.com - April 9, 2020 Category: Consumer Health News Source Type: news

Test the BCG-Covid hypothesis further
Clinical trials alone can prove causation. But in a race against time, there ’s an easy way to test the hypothesis involving the anti-TB vaccine further (Source: The Economic Times)
Source: The Economic Times - April 9, 2020 Category: Consumer Health News Source Type: news

Coronavirus death rate lower in countries using old BCG vaccine
In the UK, all schoolchildren between ten and 14 were injected with the vaccine between 1953 and 2005 but only the most at-risk now get the jab. (Source: the Mail online | Health)
Source: the Mail online | Health - April 8, 2020 Category: Consumer Health News Source Type: news

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A microbiologist in Germany believes that the use of an updated version of a 100-year-old Tuberculosis vaccine may work as an intermediate treatment for Covid-19. CNN's Frederik Pleitgen reports. (Source: CNN.com - Health)
Source: CNN.com - Health - April 4, 2020 Category: Consumer Health News Source Type: news

Can an Old Vaccine Stop the New Coronavirus?
A tuberculosis vaccine invented a century ago is cheap and safe, and seems to bolster the body ’s immune system. (Source: NYT Health)
Source: NYT Health - April 4, 2020 Category: Consumer Health News Authors: Roni Caryn Rabin Tags: your-feed-science Vaccination and Immunization Coronavirus (2019-nCoV) Infant Mortality Immune System Tuberculosis Clinical Trials Third World and Developing Countries Source Type: news

BCG vaccination policies make a ten times difference in Covid-19 incidence, mortality: New study
BCG, or Bacillus Calmette-Gu érin, is a vaccine for tuberculosis and is administered at birth in countries that have historically suffered from the disease, such as India. Many rich nations, such as the US, Italy and Holland, have never had a universal BCG vaccination policy. (Source: The Economic Times)
Source: The Economic Times - April 3, 2020 Category: Consumer Health News Source Type: news

Explainer: How an old tuberculosis vaccine might help fight the new coronavirus
There is no vaccine against the novel coronavirus, called SARS-CoV-2, that is spreading rapidly around the world. But scientists in several countries are testing a century-old tuberculosis (TB) vaccine to see if it might boost the immune system to reduce respiratory symptoms in people who get new coronavirus infections. (Source: Reuters: Health)
Source: Reuters: Health - April 2, 2020 Category: Consumer Health News Tags: healthNews Source Type: news

Nations with mandatory TB vaccines show fewer coronavirus deaths: Study
With nearly 900,000 cases and 45,000 deaths, the world is struggling to control Covid-19. (Source: The Economic Times)
Source: The Economic Times - April 2, 2020 Category: Consumer Health News Source Type: news

A Vaccine From The 1920s Is Now Being Tested For Use Against The Coronavirus Pandemic
Researchers in a handful of countries are testing a century-old tuberculosis vaccine to see if it can give a boost to the immune system to help it fight off the novel coronavirus now causing the COVID-19 pandemic. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - March 31, 2020 Category: Pharmaceuticals Authors: Eric Mack, Contributor Source Type: news

Tuberculosis vaccine could be used to prevent the spread of coronavirus
The Bacillus Calmette-Guérin (BCG) vaccine is used to fend off tuberculosis (TB) but it has long been known to have other health benefits and is now being trialled in Australia. (Source: the Mail online | Health)
Source: the Mail online | Health - March 26, 2020 Category: Consumer Health News Source Type: news

Serum Institute to test if TB vaccine VPM1002 is effective against Covid-19
Serum Institute of India, the world ’s largest vaccine manufacturer, will soon start clinical trials in the country to test if tuberculosis vaccine VPM1002 is effective as a preventive and immunity booster vaccine against Covid-19. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - March 25, 2020 Category: Pharmaceuticals Source Type: news

South Africa: Best Paper Award for UCT TB Vaccine Research
[UCT] The International Society for Vaccines (ISV) has selected a publication in which the University of Cape Town's (UCT) Professor Mark Hatherill, Professor Robert Wilkinson, Professor Tom Scriba, Dr Mich èle Tameris and Dr Friedrich Thienemann (Faculty of Health Sciences) played a key role, as the best paper of the year for 2019. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - March 24, 2020 Category: Infectious Diseases Source Type: news