100 years after development, TB vaccines vary in ability to stimulate immune components
(Boston Children's Hospital) New research from the Precision Vaccines Program at Boston Children's Hospital shows that BCG vaccines for tuberculosis prevention vary widely in their ability to activate components of the immune system. These findings highlight important differences between BCG formulations and the need for a large clinical study comparing them. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 28, 2020 Category: International Medicine & Public Health Source Type: news

Medical News Today: Giving TB vaccine intravenously boosts efficacy
New research in macaques finds that changing the delivery method of an existing tuberculosis vaccine can drastically improve its efficacy. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 21, 2020 Category: Consumer Health News Tags: Tuberculosis Source Type: news

Old TB vaccine may work better when delivered intravenously
Delivering the only approved tuberculosis vaccine intravenously greatly enhanced its ability to protect rhesus monkeys from infection. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - January 13, 2020 Category: Consumer Health News Source Type: news

Bharat Biotech keen to revive Rs 600 crore TN vaccine complex
With a planned annual capacity of 585 million, the project proposed to make pentavalent, or five-in-one, combination vaccine, BCG vaccine, and vaccines to prevent measles, hepatitis B, human rabies, Hib (haemophilus influenzae type b) and Japanese encephalitis (JE) in the first phase, which was to be commissioned by 2010. (Source: The Economic Times)
Source: The Economic Times - January 3, 2020 Category: Consumer Health News Source Type: news

TB Vaccine More Powerful When Given Intravenously
THURSDAY, Jan. 2, 2020 -- The tuberculosis (TB) vaccine is far from infallible, but new animal research suggests the problem is not the vaccine but how it is delivered. When given to monkeys intravenously rather than as an injection, the vaccine... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 2, 2020 Category: General Medicine Source Type: news

Injecting TB vaccine straight into bloodstream makes the 100-year-old shot far more effective
A new study from the National Institutes of Health has found that administering the tuberculosis vaccine straight into the vein was more effective than the shot injected into the skin. (Source: the Mail online | Health)
Source: the Mail online | Health - January 2, 2020 Category: Consumer Health News Source Type: news

New Injection Method Makes an Old TB Vaccine Far More Powerful
Giving the vaccine intravenously to monkeys provided 90% protection against tuberculosis. More testing is needed before humans can be inoculated that way. (Source: NYT)
Source: NYT - January 1, 2020 Category: American Health Authors: Donald G. McNeil Jr. Tags: Tuberculosis Vaccination and Immunization Monkeys and Apes Lungs Third World and Developing Countries National Institute of Allergy and Infectious Diseases University of Pittsburgh Nature (Journal) Seder, Robert A Africa your-feed-heal Source Type: news

Delivering TB vaccine intravenously dramatically improves potency, study shows
(University of Pittsburgh) Worldwide, more people die from tuberculosis than any other infectious disease, even though the vast majority were vaccinated. The vaccine just isn't that reliable. But a new Nature study finds that simply changing the way the vaccine is administered could dramatically boost its protective power. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 1, 2020 Category: Infectious Diseases Source Type: news

Changed route of immunization dramatically improves efficacy of TB vaccine
(NIH/National Institute of Allergy and Infectious Diseases) Tuberculosis (TB), an ancient disease, is the leading infectious cause of death globally, yet the world's only licensed TB vaccine, Bacille Calmette-Guerin (BCG), was developed a century ago. Given to infants via a needle placed just under the skin, BCG protects babies from a form of the disease called disseminated TB but is far less effective at preventing pulmonary TB, the major cause of illness and deaths, in teens or adults. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 1, 2020 Category: Infectious Diseases Source Type: news

Changed route of immunization dramatically improves efficacy of TB vaccine
NIH scientists report results from animal study. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - December 31, 2019 Category: American Health Source Type: news

Home for the holidays -- But will grandpa remember me?
(The Hebrew University of Jerusalem) Home for the Holidays - But Will Grandpa Remember Me?Now there's Hope; Hebrew University Team Finds TB Vaccine Lowers Rates of Alzheimer's Disease in Cancer Patients (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 23, 2019 Category: Cancer & Oncology Source Type: news

Research Nonprofit Shutters TB Vaccine Effort and Lays Off Scientists
A financially troubled Seattle research institute cut back programs, leaving researchers to find new homes for work on infectious diseases like tuberculosis and leprosy. (Source: NYT Health)
Source: NYT Health - December 14, 2019 Category: Consumer Health News Authors: Katie Thomas Tags: Infectious Disease Research Institute Vaccination and Immunization Tuberculosis Nonprofit Organizations Drugs (Pharmaceuticals) Leprosy (Hansen ' s Disease) Leishmaniasis Layoffs and Job Reductions Seattle (Wash) your-feed-healthcare Source Type: news

A Research Nonprofit Shutters TB Vaccine Effort and Lays Off Scientists
A financially troubled Seattle research institute cut back programs, leaving researchers to find new homes for work on infectious diseases like tuberculosis and leprosy. (Source: NYT Health)
Source: NYT Health - December 13, 2019 Category: Consumer Health News Authors: Katie Thomas Tags: Infectious Disease Research Institute Vaccination and Immunization Tuberculosis Philanthropy Nonprofit Organizations Drugs (Pharmaceuticals) Leprosy (Hansen ' s Disease) Leishmaniasis Layoffs and Job Reductions Seattle (Wash) your- Source Type: news

Common TB Vaccine Associated With Lower Lung Cancer Rates
In 60 - year follow - up, significantly lower lung cancer rates seen for those with childhood BCG vaccination (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 18, 2019 Category: Cancer & Oncology Tags: Family Medicine, Infections, Internal Medicine, Oncology, Pathology, Pediatrics, Pharmacy, Pulmonology, Journal, Source Type: news

Common TB Vaccine Associated With Lower Lung Cancer Rates
MONDAY, Nov. 18, 2019 -- Childhood vaccination with the bacille Calmette-Gu érin (BCG) vaccine is associated with a reduced risk for lung cancer, according to a study published online Sept. 25 in JAMA Network Open. Nicholas T. Usher, from the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 18, 2019 Category: Pharmaceuticals Source Type: news

CSU lands $1.2 million in NIH funding to advance work on a new tuberculosis vaccine
(Colorado State University) The research led by assistant professors Marcela Henao-Tamayo and Brendan Podell is part of a $44.8 million, seven-year award to the Infectious Disease Research Institute, based in Seattle. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 15, 2019 Category: Infectious Diseases Source Type: news

Experimental TB Vaccine Partially Effective: Study
Tested in patients with the latent form of tuberculosis, the vaccine prevented the development of the active form of infection in 50 percent more individuals compared with unvaccinated patients. (Source: The Scientist)
Source: The Scientist - October 30, 2019 Category: Science Tags: News & Opinion Source Type: news

Multiple SA institutions collaborate on cancer research involving TB vaccine
The Texas Biomedical Research Institute, Southwest Research Institute and UT Health San Antonio are teaming on a nonsurgical treatment for bladder cancer. Texas Biomed professor Jordi Torrelles and UT Health San Antonio’s Dr. Robert Svatek will be principle investigators on the new project. They will study the use of a modified Mycobacterium bovis Bacillus Calmette et Guérin, or BCG, vaccine as a treatment for a type of cancer that is expected t o affect more than 2% of the world’s population… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - October 30, 2019 Category: Pharmaceuticals Authors: W. Scott Bailey Source Type: news

New TB Vaccine Could Save Millions of Lives, Study Suggests
There are 10 million new cases each year of tuberculosis, now the leading infectious cause of death worldwide. Even a partly effective vaccine could help turn the tide. (Source: NYT Health)
Source: NYT Health - October 29, 2019 Category: Consumer Health News Authors: Donald G. McNeil Jr. Tags: Tuberculosis Vaccination and Immunization Tests (Medical) Antibiotics New England Journal of Medicine World Health Organization Gavi, the Vaccine Alliance Berkley, Seth Kenya South Africa Zambia Source Type: news

'Game changing' tuberculosis vaccine a step closer
TB is one of the top 10 causes of death worldwide and kills 1.5 million people each year. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - October 29, 2019 Category: Consumer Health News Source Type: news

GSK's tuberculosis vaccine shows promising results
The new vaccine, known as M72/AS01E, was tested at 11 sites in Kenya, South Africa and Zambia in adults whose blood tests showed they had latent TB. The study revealed that the vaccine could cut the number of people developing TB by half. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - October 29, 2019 Category: Pharmaceuticals Source Type: news

Childhood TB Shot May Offer Lung Cancer Protection
A tuberculosis vaccine commonly used in other parts of the world might reduce a person's risk of developing lung cancer if given early in childhood, a six-decade-long study reports. (Source: WebMD Health)
Source: WebMD Health - October 1, 2019 Category: Consumer Health News Source Type: news

Childhood TB Shot May Offer Long-Term Protection from Lung Cancer
TUESDAY, Oct. 1, 2019 -- A tuberculosis vaccine commonly used in other parts of the world might reduce a person's risk of developing lung cancer if given early in childhood, a six-decade-long study reports. The Bacille Calmette-Guerin (BCG) vaccine... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 1, 2019 Category: General Medicine Source Type: news

NIH awards contracts to advance tuberculosis immunology research
Research will help advance TB vaccine development. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - September 26, 2019 Category: American Health Source Type: news

QuickStats: Age-Adjusted Death Rates from Diabetes Mellitus as Underlying or Contributing Cause Among Adults Aged ≥65 Years, by Race/Ethnicity --- National Vital Statistics System, United States, 2004--2017
During 2004-2017, the death rate from diabetes mellitus as underlying or contributing cause among adults aged ≥65 years decreased in the United States. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - June 20, 2019 Category: American Health Tags: Diabetes MMWR Morbidity & Mortality Weekly Report Older Adult's Health Tuberculosis (TB) Tuberculosis Vaccine (BCG) Source Type: news

Notes from the Field: Meningeal and Pulmonary Tuberculosis on a Commercial Fishing Vessel --- Hawaii, 2017
In December 2016, U.S. Customs and Border Protection notified the CDC Honolulu Quarantine Station of a crewman on a commercial fishing vessel who was hospitalized with suspected tuberculosis. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - June 20, 2019 Category: American Health Tags: MMWR Morbidity & Mortality Weekly Report Tuberculosis (TB) Tuberculosis Vaccine (BCG) Source Type: news

Kenya: Baby's Hand, Foot Amputated After BCG Vaccination
[Nation] Mr Peter Gitonga and his wife Leah Waithira are angry and disappointed parents. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - April 11, 2019 Category: African Health Source Type: news

New tools and strategies for tuberculosis diagnosis, care, and elimination: A PLOS Medicine special
(PLOS) This week, publication of a special issue on tuberculosis (TB) begins in PLOS Medicine, advised by guest editors Richard Chaisson of Johns Hopkins University, Claudia Denkinger of the University of Heidelberg, and Mark Hatherill of the South African Tuberculosis Vaccine Institute. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 5, 2019 Category: International Medicine & Public Health Source Type: news

IDRI partners with Afrigen Biologics and Biovac to produce tuberculosis vaccine
(Infectious Disease Research Institute) In an effort to produce vaccines where they are needed most, IDRI (Infectious Disease Research Institute) is collaborating with the Cape Town, South Africa, based biotechnology startup company Afrigen Biologics, founded by the Industrial Development Corporation of South Africa and IDRI, and its production partner the Biovac Institute (Biovac), a vaccine manufacturer also located in Cape Town, to produce a vaccine for tuberculosis. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 20, 2019 Category: Infectious Diseases Source Type: news

Clinical trial starts for temperature-stable tuberculosis vaccine
Researchers have started conducting trials with an experimental tuberculosis vaccine candidate that can survive without refrigeration, the National Institutes of Health said. (Source: Health News - UPI.com)
Source: Health News - UPI.com - January 23, 2019 Category: Consumer Health News Source Type: news

Temperature-stable experimental tuberculosis vaccine enters clinical testing
Tuberculosis remains the leading infectious cause of death worldwide. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - January 23, 2019 Category: American Health Source Type: news

Temperature-stable experimental tuberculosis vaccine enters clinical testing
(NIH/National Institute of Allergy and Infectious Diseases) A Phase 1 human clinical trial is testing a freeze-dried, temperature-stable formulation of an experimental tuberculosis (TB) vaccine. The trial is being conducted at the Saint Louis University School of Medicine Center for Vaccine Development and will enroll healthy adult volunteers. The experimental vaccine, called ID93, was developed by scientists at the Infectious Disease Research Institute in Seattle. The National Institute of Allergy and Infectious Diseases is supporting the trial through a contract to IDRI. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 23, 2019 Category: Infectious Diseases Source Type: news

Africa:New Tuberculosis Vaccine Raises Hopes
[GroundUp] But one more large trial is needed, says TB activist (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - October 23, 2018 Category: Infectious Diseases Source Type: news

Africa: New Tuberculosis Vaccine Raises Hopes
[GroundUp] But one more large trial is needed, says TB activist (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - October 23, 2018 Category: Infectious Diseases Source Type: news

Q & A on the investigational vaccine candidate M72/AS01E
M72/AS01E is a subunit vaccine comprised of an immunogenic fusion protein (M72) derived from two Mycobacterium tuberculosis (M.tb) antigens (MTB32A and MTB39A), and the GlaxoSmithKline (GSK) proprietary adjuvant AS01E. AS01E is the same adjuvant used in Shingrix GSK vaccine, as well as in the new malaria vaccine RTS,S/AS01E. The M72/AS01E vaccine candidate is being developed by the pharmaceutical company GlaxoSmithKline, in partnership with AERAS. AERAS is a not for profit organization based in the US, aimed at supporting tuberculosis vaccine research, funded by the Bill and Melinda Gates foundation, the UK Department for ...
Source: WHO Feature Stories - October 10, 2018 Category: International Medicine & Public Health Tags: tuberculosis [subject], tb Source Type: news

BCG vaccine may reduce blood sugar in type-1 diabetics
Research, presented at the European Association for the Study of Diabetes conference, suggests that the bacillus Calmette-Guerin vaccine is effective at reducing blood sugar levels in people with type-1 diabetes.MedicalXpress (Source: Society for Endocrinology)
Source: Society for Endocrinology - October 5, 2018 Category: Endocrinology Source Type: news

Uganda:Ugandan Medic Develops New TB Vaccine for Adults
[Monitor] Kampala -A Ugandan medical doctor, Dr Jacqueline Akite, together with a team of other international scientists have registered landmark success by developing a new vaccine that stops the spread of pulmonary tuberculosis (TB) in adults. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - September 28, 2018 Category: Infectious Diseases Source Type: news

TB vaccine shows promise against diabetes
For Hodalis Gaytan, 20, living with Type 1 diabetes means depending on an assortment of expensive medicines and devices to stay healthy. Test strips. Needles. A glucose meter. Insulin. (Source: CNN.com - Health)
Source: CNN.com - Health - July 12, 2018 Category: Consumer Health News Source Type: news

Mixed Results with TB Vaccines in Trial
(MedPage Today) -- No difference for initial infection, but reduced rates of sustained QFT conversions versus placebo (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - July 11, 2018 Category: American Health Source Type: news

NEJM publishes final results from phase two study showing vaccines can reduce rate of sustained TB infections
(Burness) Aeras, a nonprofit organization dedicated to developing vaccines against tuberculosis (TB), today announced the publication of the full results from a Phase 2, randomized, controlled clinical trial of two TB vaccines-- the currently available BCG vaccine and an investigational vaccine, H4:IC31--in the New England Journal of Medicine (NEJM). (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 11, 2018 Category: Infectious Diseases Source Type: news

Nigeria:BCG Can Reverse Type 1 Diabetes to Almost Undetectable Levels, Eight-Year Study Shows
[Guardian] An eight-year study has shown the Bacillus Calamine Guerin (BCG) vaccine against tuberculosis can reverse Type 1 diabetes to almost undetectable levels. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 26, 2018 Category: African Health Source Type: news

TB Vaccine for T1D Study Stirs Controversy
(MedPage Today) -- Long-term data suggest BCG vaccine may alter immune attack (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - June 25, 2018 Category: American Health Source Type: news

Possible cure for diabetes? Generic drug can reverse type 1 diabetes long-term, study finds
Research at Massachusetts General Hospital looks increasingly like a long-term cure for type 1 diabetes, with a newly released study showing patients have normal blood sugar levels eight years after a clinical trial. In research published in journal npj Vaccines, patients who had been treated with the Bacillus Calmette-Guerin (BCG) vaccine — an inexpensive, generic vaccine used around the world to prevent tuberculosis — had normal blood sugar levels eight years after the trial ended. While… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - June 25, 2018 Category: Pharmaceuticals Authors: Jessica Bartlett Source Type: news

TB Vaccine Linked to Better Type 1 Diabetes Control
Title: TB Vaccine Linked to Better Type 1 Diabetes ControlCategory: Health NewsCreated: 6/21/2018 12:00:00 AMLast Editorial Review: 6/22/2018 12:00:00 AM (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - June 22, 2018 Category: Endocrinology Source Type: news

BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes
THURSDAY, June 21, 2018 -- The Bacillus Calmette Gu érin (BCG) vaccine is associated with a reduction in hyperglycemia among patients with type 1 diabetes with long-term disease, according to a study published online June 21 in npj Vaccines. Willem... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 21, 2018 Category: Pharmaceuticals Source Type: news

There ’s Hope for a Vaccine to Prevent Type 1 Diabetes
Could a vaccine for type-1 diabetes be on the horizon? In a new study, a small group of people with type 1 diabetes who were given a vaccine showed improvement in their blood sugar levels to nearly normal levels—and the changes lasted for five to eight years. The study, published Thursday in the journal npj Vaccines by researchers at Massachusetts General Hospital, looked at nine people with type 1 diabetes who were given a vaccine to prevent tuberculosis, called bacillus Calmette-Guérin (BCG). They had two injections, four weeks apart. Levels of their hemoglobin a1c (HbA1c), which measures a person’s bl...
Source: TIME: Health - June 21, 2018 Category: Consumer Health News Authors: Alexandra Sifferlin Tags: Uncategorized diabetes healthytime Source Type: news

Generic drug shows promise as diabetes vaccine in small, years-long study
A cheap, generic tuberculosis vaccine lowered blood glucose levels in nine patients with Type I diabetes and the effects lasted for years, according to a study published this week in npj Vaccines. The study was conducted at Massachusetts General Hospital by Dr. Denise Faustman – a name that has long been saddled with controversy in the diabetes community, due in large part to a dispute with the JDRF after the organization declined to fund her work. Get the full story at our sister site, Drug Delivery Business News. The post Generic drug shows promise as diabetes vaccine in small, years-long s...
Source: Mass Device - June 21, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Diabetes Pharmaceuticals Research & Development Massachusetts General Hospital Source Type: news

TB Vaccine Tied to Better Type 1 Diabetes Control
A little more than three years after getting two tuberculosis shots four weeks apart, about 50 people with type 1 diabetes saw their long-term average blood sugar levels drop significantly -- and for at least five years. (Source: WebMD Health)
Source: WebMD Health - June 21, 2018 Category: Consumer Health News Source Type: news

TB Vaccine Linked to Better Type 1 Diabetes Control
A little more than three years after getting two tuberculosis shots four weeks apart, about 50 people with type 1 diabetes saw their long-term average blood sugar levels drop significantly -- and for at least five years. (Source: WebMD Health)
Source: WebMD Health - June 21, 2018 Category: Consumer Health News Source Type: news

Diabetes Breakthrough: Common Vaccine Can Improve Blood Sugar Levels Long-Term
BOSTON (CBS) – Researchers at Mass General Hospital announced a breakthrough in treating Type 1 Diabetes. In a long-term study released Thursday, patients in a clinical trial had their blood sugar levels restored to near normal, with lasting results. Patients in the trial received two doses of the bacillus Calmette-Guerin (BCG) vaccine, an inexpensive vaccine that is widely used to prevent tuberculosis. Results were not immediate, but after three years, every patient, “showed an improvement in HbA1c to near normal levels – improvement that persisted for the following five years,” MGH said in a news ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - June 21, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Syndicated Local Diabetes Mass General Hospital Source Type: news