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An unexpected discovery in a central line
(Children's National Health System) An otherwise healthy 6-year-old had a central line that tested positive for a type of fungal infection that typically strikes adults with compromised immune systems. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 12, 2018 Category: Infectious Diseases Source Type: news

UTSA researchers explore little-known, deadly fungal infections
(University of Texas at San Antonio) A new study by Althea Campuzano, Ph.D., a student at the University of Texas at San Antonio, and Floyd Wormley, Jr., Professor of Biology and Senior Associate Dean for Research and Graduate Studies, sheds light on little-known fungal infections caused by the fungus Cryptococcus. There are currently no vaccines available for any fungal infection, which can be extremely deadly to patients under treatment for diseases like HIV, AIDS and cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 10, 2018 Category: Cancer & Oncology Source Type: news

Review of CNS fungal infections published in The Lancet Neurology
Thu, 04/05/2018 - 10:22News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - April 5, 2018 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Microscopic revelations point to new blood infection therapies
(University of Calgary) Researchers at the University of Calgary's Cumming School of Medicine (CSM) have for the first time been able to observe -- live and in real-time -- how the human body responds to often lethal fungal blood infections in the lung. In the study, the fungal infection Candida albicans was introduced to mice or human models of the lung vasculature and as blood was pumped over that system, researchers recorded what happened using highly sophisticated microscopes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 4, 2018 Category: International Medicine & Public Health Source Type: news

Online Training Global Health: Module 5 - Bacterial, Mycobacterial and Fungal Infections
Friday, December 1, 2017 (All day)  to Saturday, June 30, 2018 (All day)This " Bacterial, Mycobacterial and Fungal Infections "  module is part of the University of Minnesota Department of Medicine Online Global Health Course.Courses& Workshops (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - March 28, 2018 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Another Downside of Weight Gain: Toenail Fungus
FRIDAY, March 23, 2018 -- Piling on pounds is bad for your health from head to toe. So say Korean researchers, who report that unhealthy weight gain ups a person's odds for disfiguring toenail fungal infections. In fact, people who are statistically... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - March 23, 2018 Category: General Medicine Source Type: news

Fungal Infections in Transplant Recipients
Monday, March 19, 2018 - 10:04Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - March 19, 2018 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Pathogenesis of Ocular Fungal Infections
Monday, March 19, 2018 - 10:00Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - March 19, 2018 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Research with made-in-Canada molecule targets fungal infections worldwide
(Canadian Glycomics Network) People whose immune systems are compromised from illnesses such as cancer can also fall victim to infections caused by fungal pathogens, which have become a major. GlycoNet is funding translational research to test a unique approach using drug-like molecules that inhibit attachment of cell surface carbohydrates and have been shown to alter and weaken diverse medically important fungi. The project is led by Network Investigator, Leah Cowen, (University of Toronto) and her colleague Luke Whitesell (University of Toronto). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 19, 2018 Category: International Medicine & Public Health Source Type: news

Cryptococcal meningitis: Validation of new therapeutic regimens
(ANRS) The Advancing Cryptococcal Meningitis Treatment for Africa (ACTA) trial funded by the Medical Research Council (UK) and ANRS (France) has highlighted the benefits of new therapeutic regimens in the treatment of cryptococcal meningitis, a frequent and severe opportunistic disease in patients living with HIV. In light of these findings, reported in the March 15, 2018 issue of the New England Journal of Medicine, the WHO has changed its guidelines regarding treatment of this fungal infection. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 15, 2018 Category: International Medicine & Public Health Source Type: news

Diagnosis of Hyphae in Neuropathology Specimens Diagnosis of Hyphae in Neuropathology Specimens
What approach should be taken when neuropathology specimens reveal hyphae on initial histologic examination? The authors present an algorithm to aid in diagnosis of invasive CNS fungal infections.American Journal of Clinical Pathology (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - March 6, 2018 Category: Pathology Tags: Pathology & Lab Medicine Journal Article Source Type: news

Medical News Today: Cryptococcal meningitis: Symptoms, risk factors, and complications
Cryptococcal meningitis is a fungal infection that usually affects people with a weakened immune system. Learn about the risk factors and complications. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 26, 2018 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Geisel Researchers Further Understanding of Fungal Morphology
A new study by researchers in Geisel's Sundstrom Lab sheds new light on a previously little understood area of fungal biology and could lead to new treatments for dangerous fungal pathogens. (Source: News at Dartmouth Medical School)
Source: News at Dartmouth Medical School - February 20, 2018 Category: Hospital Management Authors: Susan Green Tags: News Research fungal infection Paula Sundstrom Source Type: news

Fungus-specific CD4 T Cells as Specific Sensors for Pulmonary Fungal Infections & Sensitization
Fungus-specific CD4 T Cells as Specific Sensors for Pulmonary Fungal Infections& SensitizationThursday, February 15, 2018 - 10:46Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - February 15, 2018 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Medical News Today: Are there any home remedies for ringworm?
A look at home remedies for ringworm, a condition that results in fungal infection on the skin. Included is detail on when to see a doctor and prevention. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 14, 2018 Category: Consumer Health News Tags: Complementary Medicine / Alternative Medicine Source Type: news

Heartbreak as Staffordshire twin sister dies from flu
Melissa Whiteley had been rushed to the Royal Stoke University Hospital's A&E as she could barely walk and tests revealed she was suffering from sepsis, flu, pneumonia and a fungal infection. (Source: the Mail online | Health)
Source: the Mail online | Health - February 8, 2018 Category: Consumer Health News Source Type: news

Can smoking marijuana cause meningitis?
Cryptococcus neoformans (wikipedia.org) 2.5 out of 5 stars Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency. Shapiro BB et al. BMJ Case Rep 2018 Jan 26 [Epub ahead of print] Abstract Can smoking marijuana cause meningitis? The question is not unreasonable. A wide range of pathogenic fungi — including Aspergillus and various Cryptococcus species — have been isolated from dispensary-grade medical marijuana samples. Concern that these pathogens could cause pneumonia or central nervous system infections has focussed on those with immunodeficiency, such...
Source: The Poison Review - February 2, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical cannabis cryptococcus fungal infection marijuana meningitis Source Type: news

Natural remedy: Honey found to have comparable effects to antifungal medications, but more affordably and without the side effects
(Natural News) Fungal diseases are a worldwide public health problem. Oftentimes, the treatment for these diseases are antibiotics. However, the use of antifungal medications are not entirely beneficial. The continuous use of antibiotics led to the increase in drug-resistant fungal infections, making them more difficult to treat. In addition, these drugs have side effects on... (Source: NaturalNews.com)
Source: NaturalNews.com - January 10, 2018 Category: Consumer Health News Source Type: news

Posaconazole Pharmacokinetics in Adults with Invasive Fungal Infections
Wed, 01/03/2018 - 15:39News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - January 3, 2018 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Could Your Salon Visit Make You Sick?
Source: HealthDay Related MedlinePlus Pages: Bacterial Infections, Fungal Infections, Occupational Health (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - December 27, 2017 Category: Consumer Health News Source Type: news

Could your local beauty salon put you at RISK of fungal infection? SHOCK research revealed
SKIN and fungal infections - including thrush, ringworm and athlete ’s foot - are caused by different types of fungi. (Source: Daily Express - Health)
Source: Daily Express - Health - December 18, 2017 Category: Consumer Health News Source Type: news

FDA launches new tool for sharing information that allows doctors to better manage antibiotic use; improve patient care
Today the FDA is announcing a new approach to get critical updates regarding antibiotics and antifungal drugs to health care professionals as part of an overall effort to combat antimicrobial resistance. The agency created a website that will provide direct and timely access to information about when bacterial or fungal infections are likely to respond to a specific drug. (Source: Food and Drug Administration)
Source: Food and Drug Administration - December 13, 2017 Category: American Health Source Type: news

FDA launches new tool for sharing information that allows doctors to better manage antibiotic use; improve patient care
Today the U.S. Food and Drug Administration is announcing a new approach to get critical updates regarding antibiotics and antifungal drugs to health care professionals as part of an overall effort to combat antimicrobial resistance. The agency created a website that will provide direct and timely access to information about when bacterial or fungal infections are likely to respond to a specific drug. (Source: World Pharma News)
Source: World Pharma News - December 13, 2017 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

Fungal Infections in Pakistan - Local Challenges
Tuesday, December 12, 2017 - 13:13Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - December 12, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Pulmonary fungal infections and susceptible hosts
Tuesday, December 12, 2017 - 13:10Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - December 12, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Pulmonary fungal infections and susceptible hosts
Tuesday, December 12, 2017 - 09:29Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - December 12, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Molecular Mycology (MOMY): Current Approaches to Fungal Pathogenesis
Fungal diseases are significant causes of mortality and morbidity in both the developed and the developing world. The recent increases in the incidence and severity of invasive fungal infections are directly attributable to new susceptible patient populations. Examples of these large, at-risk populations include patients with AIDS; hospitalized patients being treated for cancer and autoimmune disorders; andthose receiving organ transplants.Courses& Workshops (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - December 12, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Panfungal DNA sequencing assay for invasive fungal infections shows good sensitivity (97%) and specificity (98%)
Mon, 11/27/2017 - 12:21News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 27, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Evaluating CT guided lung biopsies for diagnosing fungal infection
Wed, 11/22/2017 - 11:23News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 22, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Preclinical Evaluation of the Stability, Safety and Efficacy of CD101, a Novel Echinocandin
Fungal infections pose a significant public health burden with high morbidity and mortality. CD101 is a novel echinocandin under development for the treatment and prevention of systemic Candida infections. Preclinical studies were conducted to evaluate the metabolic stability, plasma protein binding, pharmacokinetics, toxicity, and efficacy of CD101 at various dose levels. CD101 was stable to biotransformation in rat/monkey/human liver microsomes and rat/monkey/dog/human hepatocytes. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 1, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Medical News Today: Onycholysis: Treatments for detached nails
Onycholysis is when the nails detach from the skin underneath. This can be caused by a number of conditions, including psoriasis and fungal infections. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 29, 2017 Category: Consumer Health News Tags: Dermatology Source Type: news

Medical News Today: Why do toenails become thick?
This article also examines available treatments. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 29, 2017 Category: Consumer Health News Tags: Dermatology Source Type: news

New and emerging treatments for fungal infections.
Although several new antifungal drugs have been licensed in the last 5 years, some patients remain difficult to treat. The main reasons for this include intrinsic or acquired antifungal resistance, organ dysfunction preventing the use of some agents and drug interactions. In addition, some drugs penetrate poorly into sanctuary sites including eye and urine, and others are associated with considerable adverse events. Here, we review the preclinical and clinical development progress with four new antifungal agents: isavuconazole, ravuconazole,albaconazole and aminocandin. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

New categories of hematological malignancies at risk for invasive fungal infections
Friday, October 13, 2017 - 15:46Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Global burden of fungal infections
Friday, October 13, 2017 - 09:24Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids
Recent estimates suggest that>300 million people are afflicted by serious fungal infections worldwide. Currentantifungal drugs are static and toxic and/or have a narrow spectrum of activity. Thus, there is an urgent need for the development of newantifungal drugs. The fungal sphingolipid glucosylceramide (GlcCer) is critical in promoting virulence of a variety of human-pathogenic fungi. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Fungal infection warning: FUNGUS kills more people than malaria a year
FUNGAL infections, like athlete ’s foot and ringworm, can usually be easily treated. But invading fungus still kills more people a year than malaria. (Source: Daily Express - Health)
Source: Daily Express - Health - October 11, 2017 Category: Consumer Health News Source Type: news

Drugs in Clinical Development for Fungal Infections (includes MAT023, encochleated amphotericin B))
Despite increasing rates of invasive fungal infections being reported globally, only a single antifungal drug has been approved during the last decade. Resistance, toxicity, drug interactions and restricted routes of administration remain unresolved issues. This review focuses on new antifungal compounds which are currently in various clinical phases of development. We discuss two azoles with a tetrazole moiety that allows selective activity against the fungal CYP: VT-1161 for Candida infections and VT-1129 for cryptococcal meningoencephalitis. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 10, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

A step towards a new drug to treat fungal infections that kill 1.6 million people annually
(Westmead Institute for Medical Research) A team from Sydney's Westmead Institute for Medical Research is a step closer to developing a drug to treat life-threatening fungal infections that cause more than 1.6 million deaths annually. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 10, 2017 Category: International Medicine & Public Health Source Type: news

Fungal infections: New drug to treat life-threatening conditions
AN ANTIFUNGAL drug could be developed to treat life-threatening fungal infections, that cause coughing up blood. (Source: Daily Express - Health)
Source: Daily Express - Health - October 9, 2017 Category: Consumer Health News Source Type: news

Researchers help develop new antifungal drug
(University of Liverpool) University researchers, working with F2G Limited (Eccles, Manchester), have developed a new antifungal drug to help in the treatment of life threatening invasive fungal infections such as invasive aspergillosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 6, 2017 Category: International Medicine & Public Health Source Type: news

Drugs in Clinical Development for Fungal Infections (review includes CD101)
Despite increasing rates of invasive fungal infections being reported globally, only a single antifungal drug has been approved during the last decade. Resistance, toxicity, drug interactions and restricted routes of administration remain unresolved issues. This review focuses on new antifungal compounds which are currently in various clinical phases of development. We discuss two azoles with a tetrazole moiety that allows selective activity against the fungal CYP: VT-1161 for Candida infections and VT-1129 for cryptococcal meningoencephalitis. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 5, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Immune Cells Trigger Spore Suicide, Stopping Fungal Infection
Tue, 10/03/2017 - 13:20News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 3, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Steering the immune defense against fungal pathogens
(Wiley) Fungal infections represent an increasing health crisis, especially for immune-deficient patients. American scientists now report in the journal Angewandte Chemie that specific help could be provided by small-molecule immunotherapeutics with novel mechanism of action. They developed small bifunctional molecules that simultaneously bind both chitin, a specific feature of the fungal cell wall and a molecule not found in humans, and naturally occurring human antibodies and redirect the human immune system to eliminate fungal pathogens. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 20, 2017 Category: Infectious Diseases Source Type: news

A Novel Approach to Fighting Fungal Infection
Mon, 09/18/2017 - 15:12News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - September 18, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi.
Wiederhold NP, Patterson TF, Srinivasan A, Chaturvedi AK, Fothergill AW, Wormley FL, Ramasubramanian AK, Lopez-Ribot JL.Virulence. 2017 Feb 17;8(2):138-142.Abstract:  Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - September 13, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Cochrane Skin Group celebrate 20 years of improving treatment of skin diseases
World-leading dermatologists and their patients are celebrating huge improvements in the treatment of skin diseases like skin cancer, psoriasis, and acne as theCochrane Skin Group marks its 20th anniversary this week.   The effects of the 120 plus published Cochrane Skin Reviews have been far-reaching and have had real impacts on patient care. These include skin cancer, skin allergies, and acne, blistering diseases, hair disorders like alopecia, fungal infections and psoriasis as well as tropical parasitic disea ses.The group is coordinated by the University of Nottingham ’s Centre of Evidence Based Dermatology ...
Source: Cochrane News and Events - September 12, 2017 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Storming the cellular barricades to fight fungi
Yale scientists have developed a new class of molecules that attack fungal infections, offering a possible therapeutic approach to treating fungal illnesses. (Source: Yale Science and Health News)
Source: Yale Science and Health News - September 12, 2017 Category: Universities & Medical Training Source Type: news