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Preclinical Evaluation of the Stability, Safety and Efficacy of CD101, a Novel Echinocandin
Fungal infections pose a significant public health burden with high morbidity and mortality. CD101 is a novel echinocandin under development for the treatment and prevention of systemic Candida infections. Preclinical studies were conducted to evaluate the metabolic stability, plasma protein binding, pharmacokinetics, toxicity, and efficacy of CD101 at various dose levels. CD101 was stable to biotransformation in rat/monkey/human liver microsomes and rat/monkey/dog/human hepatocytes. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - November 1, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Medical News Today: Onycholysis: Treatments for detached nails
Onycholysis is when the nails detach from the skin underneath. This can be caused by a number of conditions, including psoriasis and fungal infections. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 29, 2017 Category: Consumer Health News Tags: Dermatology Source Type: news

Medical News Today: Why do toenails become thick?
This article also examines available treatments. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 29, 2017 Category: Consumer Health News Tags: Dermatology Source Type: news

New and emerging treatments for fungal infections.
Although several new antifungal drugs have been licensed in the last 5 years, some patients remain difficult to treat. The main reasons for this include intrinsic or acquired antifungal resistance, organ dysfunction preventing the use of some agents and drug interactions. In addition, some drugs penetrate poorly into sanctuary sites including eye and urine, and others are associated with considerable adverse events. Here, we review the preclinical and clinical development progress with four new antifungal agents: isavuconazole, ravuconazole,albaconazole and aminocandin. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

New categories of hematological malignancies at risk for invasive fungal infections
Friday, October 13, 2017 - 15:46Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Global burden of fungal infections
Friday, October 13, 2017 - 09:24Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids
Recent estimates suggest that>300 million people are afflicted by serious fungal infections worldwide. Currentantifungal drugs are static and toxic and/or have a narrow spectrum of activity. Thus, there is an urgent need for the development of newantifungal drugs. The fungal sphingolipid glucosylceramide (GlcCer) is critical in promoting virulence of a variety of human-pathogenic fungi. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Fungal infection warning: FUNGUS kills more people than malaria a year
FUNGAL infections, like athlete ’s foot and ringworm, can usually be easily treated. But invading fungus still kills more people a year than malaria. (Source: Daily Express - Health)
Source: Daily Express - Health - October 11, 2017 Category: Consumer Health News Source Type: news

Drugs in Clinical Development for Fungal Infections (includes MAT023, encochleated amphotericin B))
Despite increasing rates of invasive fungal infections being reported globally, only a single antifungal drug has been approved during the last decade. Resistance, toxicity, drug interactions and restricted routes of administration remain unresolved issues. This review focuses on new antifungal compounds which are currently in various clinical phases of development. We discuss two azoles with a tetrazole moiety that allows selective activity against the fungal CYP: VT-1161 for Candida infections and VT-1129 for cryptococcal meningoencephalitis. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 10, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

A step towards a new drug to treat fungal infections that kill 1.6 million people annually
(Westmead Institute for Medical Research) A team from Sydney's Westmead Institute for Medical Research is a step closer to developing a drug to treat life-threatening fungal infections that cause more than 1.6 million deaths annually. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 10, 2017 Category: International Medicine & Public Health Source Type: news

Fungal infections: New drug to treat life-threatening conditions
AN ANTIFUNGAL drug could be developed to treat life-threatening fungal infections, that cause coughing up blood. (Source: Daily Express - Health)
Source: Daily Express - Health - October 9, 2017 Category: Consumer Health News Source Type: news

Researchers help develop new antifungal drug
(University of Liverpool) University researchers, working with F2G Limited (Eccles, Manchester), have developed a new antifungal drug to help in the treatment of life threatening invasive fungal infections such as invasive aspergillosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 6, 2017 Category: International Medicine & Public Health Source Type: news

Drugs in Clinical Development for Fungal Infections (review includes CD101)
Despite increasing rates of invasive fungal infections being reported globally, only a single antifungal drug has been approved during the last decade. Resistance, toxicity, drug interactions and restricted routes of administration remain unresolved issues. This review focuses on new antifungal compounds which are currently in various clinical phases of development. We discuss two azoles with a tetrazole moiety that allows selective activity against the fungal CYP: VT-1161 for Candida infections and VT-1129 for cryptococcal meningoencephalitis. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 5, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Immune Cells Trigger Spore Suicide, Stopping Fungal Infection
Tue, 10/03/2017 - 13:20News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 3, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Steering the immune defense against fungal pathogens
(Wiley) Fungal infections represent an increasing health crisis, especially for immune-deficient patients. American scientists now report in the journal Angewandte Chemie that specific help could be provided by small-molecule immunotherapeutics with novel mechanism of action. They developed small bifunctional molecules that simultaneously bind both chitin, a specific feature of the fungal cell wall and a molecule not found in humans, and naturally occurring human antibodies and redirect the human immune system to eliminate fungal pathogens. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 20, 2017 Category: Infectious Diseases Source Type: news

A Novel Approach to Fighting Fungal Infection
Mon, 09/18/2017 - 15:12News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - September 18, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi.
Wiederhold NP, Patterson TF, Srinivasan A, Chaturvedi AK, Fothergill AW, Wormley FL, Ramasubramanian AK, Lopez-Ribot JL.Virulence. 2017 Feb 17;8(2):138-142.Abstract:  Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - September 13, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Cochrane Skin Group celebrate 20 years of improving treatment of skin diseases
World-leading dermatologists and their patients are celebrating huge improvements in the treatment of skin diseases like skin cancer, psoriasis, and acne as theCochrane Skin Group marks its 20th anniversary this week.   The effects of the 120 plus published Cochrane Skin Reviews have been far-reaching and have had real impacts on patient care. These include skin cancer, skin allergies, and acne, blistering diseases, hair disorders like alopecia, fungal infections and psoriasis as well as tropical parasitic disea ses.The group is coordinated by the University of Nottingham ’s Centre of Evidence Based Dermatology ...
Source: Cochrane News and Events - September 12, 2017 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Storming the cellular barricades to fight fungi
Yale scientists have developed a new class of molecules that attack fungal infections, offering a possible therapeutic approach to treating fungal illnesses. (Source: Yale Science and Health News)
Source: Yale Science and Health News - September 12, 2017 Category: Universities & Medical Training Source Type: news

Storming the cellular barricades to fight fungi
(Yale University) Yale scientists have developed a new class of small molecules that attack fungal infections by clinging to the cell wall of harmful fungi and recruiting a swarm of antibodies to join the fight. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 12, 2017 Category: Cancer & Oncology Source Type: news

Fungal Infection Trust (FIT) Burden Document Updated
FIT publish a detailed summary of the worldwide total burden of fungal disease on their website. It has just beenupdated here. Updates (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - August 31, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Fungal infection warning: Why you should NEVER wear unwashed socks
FUNGAL infections include athlete ’s foot. It’s contagious and can become dangerous if spread - here’s how to avoid developing symptoms. (Source: Daily Express - Health)
Source: Daily Express - Health - August 8, 2017 Category: Consumer Health News Source Type: news

Amplyx Pharmaceuticals Raises $67 Million in Series C Financing
Funds to support clinical development of APX001, compound with novel mechanism to treat life-threatening fungal infections SAN DIEGO, Aug. 2, 2017 -- (Healthcare Sales & Marketing Network) -- Amplyx Pharmaceuticals, a company developing novel antifunga... Biopharmaceuticals, Venture Capital Amplyx Pharmaceuticals (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - August 2, 2017 Category: Pharmaceuticals Source Type: news

New insights into diagnosing and treating invasive fungal infections will help save lives
(Westmead Institute for Medical Research) Thousands of patients suffering from invasive fungal infections in intensive-care units or after organ transplantation will benefit from the latest insights into diagnostic and therapeutic interventions. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - August 1, 2017 Category: Infectious Diseases Source Type: news

Research on nitric oxide-releasing nanoparticles reveals viable skin infection treatment
(George Washington University) A research team led by Adam Friedman, MD, associate professor of dermatology at the GW School of Medicine and Health Sciences, has found that topically applied nitric oxide-releasing nanoparticles are a viable treatment for deep fungal infections of the skin caused by dermatophytes. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - July 31, 2017 Category: International Medicine & Public Health Source Type: news

When Is It Nail Fungus?
Dermatologist says only an expert can diagnose condition accurately Source: HealthDay Related MedlinePlus Pages: Fungal Infections, Nail Diseases (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - July 27, 2017 Category: Consumer Health News Source Type: news

The Lancet Series Exposes Global Paucity of Care for Life Threatening Fungal Infections
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 26, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Invasive fungal infections secondary to traumatic injury - Kronen R, Liang SY, Bochicchio G, Bochicchio K, Powderly WG, Spec A.
Invasive fungal infection (IFI) is a rare but serious complication of traumatic injury. The purpose of this article is to review the epidemiology, natural history, mycology, risk factors, diagnosis, treatment, and outcomes associated with post-traumatic IF... (Source: SafetyLit)
Source: SafetyLit - July 22, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Fungal infection: Do YOU know the five types that can affect the buttock and groin?
FUNGAL infections are common in humans and can happen when fungus overrides the immune system to take over an area of the body. (Source: Daily Express - Health)
Source: Daily Express - Health - July 21, 2017 Category: Consumer Health News Source Type: news

It's not just antibacterial resistance; now FUNGAL resistance labeled a huge threat to medicine
(Natural News) The current microbial resistance crisis has given way to yet another potential medical crisis by way of fungal drug resistance, said Ambalika Batra, a post-doctoral scientist at Royal Holloway University in London. According to Batra, patients were dying as physicians were finding it increasingly challenging to address fungal infections. According to the expert, fungal infections... (Source: NaturalNews.com)
Source: NaturalNews.com - July 7, 2017 Category: Consumer Health News Source Type: news

eCourse in fungal microscopy
Direct microscopy is a rapid method for distinguishing many fungal infections using microscopic methods with specific stains. This is the first online microscopy course for fungal infections.Courses& Workshops (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - July 3, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Statement from FDA Commissioner Scott Gottlieb, M.D., on the importance of the Drug Quality and Security Act and overseeing the safety of compounded drugs
In late 2012, the United States faced the most serious outbreak associated with contaminated compounded drugs in recent history, involving hundreds of people, in many states, who developed fungal infections related to a compounded product. It was an incident that resulted in dozens of deaths. (Source: Food and Drug Administration)
Source: Food and Drug Administration - June 27, 2017 Category: American Health Source Type: news

Can coffee machines and kettles spread toxic spores?
Conclusion This laboratory study suggests that under humid conditions, indoor surfaces like wallpaper may be colonised by fungi that produce toxic particles – some of which may be small enough to be inhaled. But it's important that these findings aren't taken too far out of context at this stage. The study was carried out in highly experimental circumstances where both temperature and humidity were optimised for maximal fungal growth. We can't know for sure that these circumstances would be typical of indoor environments, even bathrooms or kitchens, if they're well ventilated. The UK media has applied these findin...
Source: NHS News Feed - June 26, 2017 Category: Consumer Health News Tags: Heart/lungs Lifestyle/exercise Source Type: news

Statement from FDA Commissioner Scott Gottlieb, M.D., on the importance of the Drug Quality and Security Act and overseeing the safety of compounded drugs
In late 2012, the United States faced the most serious outbreak associated with contaminated compounded drugs in recent history, involving hundreds of people, in many states, who developed fungal infections related to a compounded product. It was an incident that resulted in dozens of deaths. (Source: World Pharma News)
Source: World Pharma News - June 26, 2017 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

Medical News Today: Histoplasmosis: Causes, risk factors, and treatment
Histoplasmosis is a fungal infection with a variety of flu-like symptoms. Although it is not contagious, it can cause chronic complications. Learn more. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 24, 2017 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Medical News Today: Fungal infections: Types and treatment
Who may be at risk from a fungal infection? What are the different types of fungal infections and what are their symptoms and treatment options? (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 17, 2017 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Blocking gene expression to combat deadly fungal infection
(University of Southern California) Deadly fungal infections are becoming resistant to common treatments, but a team of researchers from USC and from France have found a potential new solution. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 14, 2017 Category: International Medicine & Public Health Source Type: news

From Genome Research: Environmental pressures on opportunistic fungal pathogen
(Cold Spring Harbor Laboratory) With an estimated one million cases diagnosed worldwide each year, the human pathogen Cryptococcus neoformans, which can cause life-threatening fungal infections in immunocompromised patients, is an important health concern. In a study published today in Genome Research, scientists identified natural genomic variation in C. neoformans that may influence prevalence and disease severity. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 13, 2017 Category: Infectious Diseases Source Type: news

Everything You Ever Wanted To Know About Getting Botox In Your Groin
Most of us are familiar with botulinum toxin injections (commonly known by their brand names as Botox, Dysport and Xeomin) to erase facial wrinkles.  But Botox can also help people who suffer from excessive sweating, which is known as hyperhidrosis. In order to put a halt to sweating, it’s become increasingly more common to receive Botox injections in the armpits. And now, people are getting injections in their groin, as well.  HuffPost recently spoke with Dr. John H.Tu, M.D. from the University of Rochester Department of Dermatology and dermatologist for Dermatology Associates of Rochester. He fi...
Source: Healthy Living - The Huffington Post - June 5, 2017 Category: Consumer Health News Source Type: news

Fruity with a note of fungus: How fungal infections change the aroma of wine
(Frontiers) A recent study examining how two common types of fungal infection affect the aroma of wine reveals that both bunch rot (Botrytis cinerea) and powdery mildew (Erysiphe necator) do in fact change the aroma of wine, due to changes in chemical aroma substance composition. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 30, 2017 Category: Biology Source Type: news

ERROR: ISHAM Newsletter
For those who received a copy of the ISHAM newsletter on or around 19th May 2017 (i.e. end of last week) ISHAM have discovered that one of the conferences featured is not one they wish  to associate with as members have highlighted that it falls below a standard they would expect.The conference in question is  The Annual Congress on Fungal Infections, Diseases& Treatment is planned November 16-17, 2017 in Atlanta, Georgia, U.S.A., organized by Pulsus Group Inc.Updates (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - May 24, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

New production method to cut costs of meningitis drugs
The weakened immune system in people with HIV/AIDS makes them particularly vulnerable to fungal infections such as cryptococcal meningitis, which can be deadly. The medicine used to treat the condition is flucytosine, and EU-funded researchers have developed a new and more efficient way of producing it. This will cut production costs, making it more affordable for people in low-income countries. (Source: EUROPA - Research Information Centre)
Source: EUROPA - Research Information Centre - April 26, 2017 Category: Research Source Type: news

Antifungal peptides: a potential new class of antifungals for treating vulvovaginal candidiasis caused by fluconazole-resistant Candida albicans.
Vulvovaginal candidiasis/candidosis is a common fungal infection afflicting approximately 75% of women globally caused primarily by the yeast Candida albicans. Fluconazole is widely regarded as the antifungal drug of choice since its introduction in 1990 due to its high oral bioavailability, convenient dosing regimen and favourable safety profile. However, its widespread use has led to the emergence of fluconazole-resistant C. albicans, posing a universal clinical concern. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - April 24, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Frontiers International Conference on Disease Mechanisms Underlying Fungal Infections and Chronic Mucocutaneous Candidiasis
Date: Monday, April 24, 2017Year: 2017Location: Nijmegen, The Netherlands (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - April 24, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Key mechanism in the plant defense against fungal infections
Fungi cause important crop losses and pose a serious risk for human and animal health. A team of scientists has discovered a new component of the plant defense system against fungal infections. This finding provides new tools for developing plants resistant to fungal infections. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 10, 2017 Category: Science Source Type: news

5th Diagnosis and Therapy of Fungal Diseases - 5th DTFD: Fungal Diseases in Neonates
DTFD has become an important and essential national meeting in the field of fungal diseases, a forum in which mycologists, clinicians and basic researchers from different fields exchange research results and opinions on medical mycology practice. The outstanding scientific program will include plenary sessions on fungal infections.Courses& Workshops (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - April 7, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

A deadly fungus that's killed millions of bats in the Northeast has spread to Texas
Bad news for bats: White-nose syndrome, a disease caused by a fungus that has been killing millions of bats across the Northeast, has reached Texas.Conservationists and state and federal wildlife officials confirmed in March that the fungal infection has been detected in bats in the Texas panhandle.... (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - April 6, 2017 Category: Science Authors: Amina Khan Source Type: news

A Step Forward for Treatment of Fungal Infection Worldwide
Wed, 04/05/2017 - 08:00News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - April 5, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Napping flies have higher resistance to deadly human pathogen
(University of Maryland) A new University of Maryland study finds that fruit flies that take frequent naps have the strongest resistance to both a fungal infection and to Drosophila 'superbug' bacteria. The unexpected finding of dual resistance to the two different pathogens suggests genes regulating factors involved in general immune system resistance to disease played a bigger role than did the genes conferring disease-specific resistance. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 30, 2017 Category: Infectious Diseases Source Type: news