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Studies: Biologic Proves Worth as Monotherapy in RA (CME/CE)
(MedPage Today) -- A replacement for methotrexate in some patients? (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - August 14, 2017 Category: Geriatrics Source Type: news

Arthritis warning: THIS common medication could be linked to deadly liver failure
ARTHRITIS causes symptoms including painful joints and stiffness. One type, rheumatoid arthritis, is often treated with medications that reduce discomfort - but the side effects of the drug methotrexate, can include liver failure. (Source: Daily Express - Health)
Source: Daily Express - Health - August 10, 2017 Category: Consumer Health News Source Type: news

New research shows drug used for arthritis can treat blood cancer
A new study funded by the UK Medical Research Council (MRC) has revealed that the arthritis drug methotrexate (MTX) can be used to treat patients with a type of blood cancer, polycythemia vera (PV). (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - August 6, 2017 Category: Pharmaceuticals Source Type: news

MTX-induced Hypersensitivity Pneumonitis After 30 Years of Use MTX-induced Hypersensitivity Pneumonitis After 30 Years of Use
Methotrexate pneumonitis is not uncommon, but most frequently occurs within the first year of treatment. Could this patient's hypersensitivity pneumonitis be due to her 30 years on MTX?Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 31, 2017 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

Evaluation of toxicity after acute accidental methotrexate ingestions in children under 6 years old: a 16-year multi-center review - Hays H, Beuhler MC, Spiller HA, Weber J, Mowry JB, Ryan ML, Spiller NE, Webb A.
CONTEXT: There is little data on the frequency of adverse events following acute methotrexate ingestions in pediatric patients. Likewise, recommendations for observation length, site and management strategies in this population are not well established. Th... (Source: SafetyLit)
Source: SafetyLit - July 25, 2017 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Can Methotrexate Cause Growths on Your Wrist?
Title: Can Methotrexate Cause Growths on Your Wrist?Category: Doctor's& Expert's views on SymptomsCreated: 7/21/2017 12:00:00 AMLast Editorial Review: 7/21/2017 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - July 21, 2017 Category: Rheumatology Source Type: news

Nausea Common with Methotrexate in JIA (CME/CE)
(MedPage Today) -- Mitigating strategies include folate supplementation, anti-emetics (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - July 1, 2017 Category: Consumer Health News Source Type: news

Filgotinib Combined With MTX in Patients With Active RA Filgotinib Combined With MTX in Patients With Active RA
The addition of filgotinib may be an effective option for patients with active rheumatoid arthritis who did not sufficiently respond to methotrexate alone.Annals of the Rheumatic Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 21, 2017 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Fish as Medicine for Rheumatoid Arthritis
Eating fish may help reduce the joint pain and swelling of rheumatoid arthritis, a new study has found. (Source: NYT Health)
Source: NYT Health - June 21, 2017 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Fish and Other Marine Life Rheumatoid Arthritis Joints (Body Part) Methotrexate (Drug) Source Type: news

Tocilizumab Triumphs in Methotrexate Combo for RA Tocilizumab Triumphs in Methotrexate Combo for RA
It is not always clear which biologic to add to methotrexate for rheumatoid arthritis, but a new comparison between tocilizumab and a number of TNF inhibitors has some suggestions.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 20, 2017 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Rasuvo (Methotrexate Non-pyrogenic Solution for a Single Subcutaneous Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 31, 2017 Category: Drugs & Pharmacology Source Type: news

Moderate Alcohol Intake OK for RA Patients on Methotrexate
(MedPage Today) -- Patients on higher doses of meds may still need to abstain (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - May 30, 2017 Category: Primary Care Source Type: news

Triple Therapy More Cost-Effective Than MTX + Biologic in RA Triple Therapy More Cost-Effective Than MTX + Biologic in RA
Switching patients with MTX-resistant RA to triple-drug therapy (methotrexate, hydroxychloroquine, sulfasalazine) was recommended before changing to more expensive biologic therapy.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 30, 2017 Category: Consumer Health News Tags: Rheumatology News Source Type: news

In Rheumatoid Arthritis, Adding a Biologic Agent Before Trying Triple Therapy Likely Not Cost-Effective (FREE)
By Amy Orciari Herman Edited by David G. Fairchild, MD, MPH For patients with active rheumatoid arthritis despite methotrexate therapy, adding a biologic agent (e.g., etanercept) before trying triple therapy would lead to substantial cost increases without much … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - May 30, 2017 Category: Primary Care Source Type: news

Biologics before triple therapy not cost effective for rheumatoid arthritis
(American College of Physicians) Stepping up to biologic therapy when methotrexate monotherapy fails offers minimal incremental benefit over using a combination of drugs known as triple therapy, yet incurs large costs for treating rheumatoid arthritis (RA). Results of a comprehensive cost-effectiveness analysis suggest that patients who have RA and no contraindications to triple therapy should use it prior to a biologic as the next regimen. The study is published in Annals of Internal Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 29, 2017 Category: International Medicine & Public Health Source Type: news

FDA Approves Sarilumab for Adults With Rheumatoid Arthritis FDA Approves Sarilumab for Adults With Rheumatoid Arthritis
The drug will be marketed in self-injectible prefilled syringes and pens to be used once every 2 weeks. It offers an alternative to drugs such as methotrexate.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 23, 2017 Category: Consumer Health News Tags: Rheumatology News Alert Source Type: news

FDA Gives Nod to Sarilumab for Rheumatoid Arthritis
(MedPage Today) -- Can be used as monotherapy or with methotrexate for active RA (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - May 23, 2017 Category: American Health Source Type: news

Sanofi and Regeneron announce FDA Approval of Kevzara ® (sarilumab) for the treatment of moderately to severely active rheumatoid arthritis in adult patients
Sanofi and Regeneron Pharmaceuticals, Inc. have announced the U.S. Food and Drug Administration (FDA) approval of Kevzara® (sarilumab) for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to one or more disease modifying antirheumatic drugs (DMARDs), such as methotrexate (MTX). (Source: World Pharma News)
Source: World Pharma News - May 23, 2017 Category: Pharmaceuticals Tags: Featured Sanofi Business and Industry Source Type: news

Four-week Methotrexate Break Improves Flu Shot Response in RA Patients Four-week Methotrexate Break Improves Flu Shot Response in RA Patients
Temporarily withholding methotrexate (MTX) can improve the efficacy of seasonal influenza vaccination in patients with rheumatoid arthritis (RA), according to a new randomized clinical trial.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - May 18, 2017 Category: Allergy & Immunology Tags: Rheumatology News Source Type: news

Methotrexate Sodium Injection (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - May 18, 2017 Category: Drugs & Pharmacology Source Type: news

Adalimumab Effective in Children and Adolescents With Severe Psoriasis Adalimumab Effective in Children and Adolescents With Severe Psoriasis
Adalimumab offers benefits over methotrexate in children and adolescents with severe chronic plaque psoriasis, according to a phase 3 trial.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 15, 2017 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Mayo Clinic Q and A: Treatment often can keep morphea symptoms in check
DEAR MAYO CLINIC: About six months ago, a large, white dent appeared on my left buttock. After a biopsy, I was diagnosed with morphea. I was told that it is not systemic, but that the drug methotrexate could prevent future skin lesions and possibly cure the morphea. Is this possible, and what are the risks [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - May 6, 2017 Category: Databases & Libraries Source Type: news

Xatmep (Methotrexate Oral Solution) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 4, 2017 Category: Drugs & Pharmacology Source Type: news

Baricitinib for RA Bests Methotrexate at 1 Year (CME/CE)
(MedPage Today) -- Daily oral JAK inhibitor improves most disease measures (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - April 28, 2017 Category: Geriatrics Source Type: news

BSR: Baricitinib for RA Bests Methotrexate at 1 Year (CME/CE)
(MedPage Today) -- Daily oral JAK inhibitor improves most disease measures (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - April 28, 2017 Category: Geriatrics Source Type: news

BSR: Genetic Analysis IDs Methotrexate Responders (CME/CE)
(MedPage Today) -- Gene biomarkers differentiated between good responders and nonresponders (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - April 28, 2017 Category: Geriatrics Source Type: news

FDA Approves Xatmep (methotrexate) Oral Solution
Denver, April 26, 2017 — Silvergate Pharmaceuticals, Inc. leaders in the development and commercialization of innovative and safe medicines for children, today announced that the United States Food and Drug Administration (FDA) approved Xatmep... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - April 26, 2017 Category: Drugs & Pharmacology Source Type: news

FDA Approves XATMEP(TM), the First and Only Ready-To-Use Methotrexate Oral Solution
DENVER, April 26, 2017 -- (Healthcare Sales & Marketing Network) -- Silvergate Pharmaceuticals, Inc. (www.silvergatepharma.com), leaders in the development and commercialization of innovative and safe medicines for children, today announced that the Unite... Biopharmaceuticals, FDA Silvergate Pharmaceuticals, XATMEP, methotrexate, arthritis (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - April 26, 2017 Category: Pharmaceuticals Source Type: news

Methotrexate Sodium Injection (New - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - April 24, 2017 Category: Drugs & Pharmacology Source Type: news

Rheumatoid arthritis patients 'have experienced progress in recent decades'
This study confirms how important early diagnosis and the commencement of treatment is. It is also encouraging to hear about the progress that has been made over the last 20 years. "Now the scientific community must continue to build on this, so that together we can continue to harness the power of exceptional science and make everyday life better for all people with arthritis." (Source: Arthritis Research UK)
Source: Arthritis Research UK - April 18, 2017 Category: Rheumatology Source Type: news

What Causes Uveitis?
Discussion Inflammation of the middle layer of the eye, or uvea, is termed uveitis. Uveitis can be divided into anterior, intermediate or posterior uveitis by involving the anterior (iris and ciliary body), intermediate (vitreous) or posterior (choroid and usually retina) compartments. Panuveitis involves all 3 compartments. Duration can also be used to classify uveitis. Acute is 6 weeks and> 3 months is chronic persistent uveitis. Episodic periods of inactivity and reactivity that last more than 3 months are called recurrent uveitis. A third way to characterize uveitis is if it is granulomatous or not. Uveitis increase...
Source: PediatricEducation.org - April 3, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Moderate drinking 'does not risk liver damage for methotrexate users'
People receiving the common rheumatoidarthritis therapymethotrexate can safely drink moderate amounts of alcohol without running the risk of liver damage. This is according to a new study from the University of Manchester, funded by Arthritis Research UK, which shows that drinking 14 units of alcohol or fewer per week is not likely to cause any liver health issues. Sticking to modest levels of drinking'likely to be safe' Methotrexate is often taken over extended periods of time to limit or prevent joint damage and disability associated withrheumatoid arthritis. Generally, those receiving the drug are advised to abs...
Source: Arthritis Research UK - March 28, 2017 Category: Rheumatology Source Type: news

XELJANZ ® (tofacitinib citrate) receives marketing authorisation in the European Union for the treatment of moderate to severe active rheumatoid arthritis
Pfizer Inc. (NYSE:PFE) announced today that the European Commission (EC) has approved XELJANZ® (tofacitinib citrate) 5 mg twice daily (BID) oral tablets in combination with methotrexate (MTX) for the treatment of moderate to severe active rheumatoid arthritis (RA) in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying antirheumatic drugs (DMARDs). (Source: World Pharma News)
Source: World Pharma News - March 27, 2017 Category: Pharmaceuticals Tags: Featured Pfizer Business and Industry Source Type: news

The only kids who need vitamins (spoiler alert: there aren ’t many)
As a pediatrician, I get a lot of questions whether their children should take a multivitamin or other vitamin supplement. Parents think they will make their children healthier — and some think they will make them eat more (they don’t, sorry). Since our bodies need different vitamins to be healthy, they ask, Should I give my child a multivitamin? Not necessarily, actually. It turns out that most children don’t need them, making them an expensive waste of money. They can also be dangerous if children take too many, something that is very possible given that most chewable multivitamins for children taste li...
Source: Thrive, Children's Hospital Boston - March 23, 2017 Category: Pediatrics Authors: Claire McCarthy Tags: Ask the Expert Health & Wellness Claire McCarthy vitamins Source Type: news

Masonic Charitable Foundation awards grant to microbiome research
The Masonic Charitable Foundation has awarded£90,000 over three years to Arthritis Research UK, to support research into the role of the microbiome in rheumatoid arthritis.The grant will support Dr Frances Williams at King’s College London, to explore whether the mix of bacteria in and on our bodies (known as the microbiome) drives rheumatoid arthritis, or whether changes in these bacteria are a consequence of the disease or the drugs used to treat it.The researchAround 400,000 people in the UK have rheumatoid arthritis but the best drugs available do not work for everyone. We know that the microbiome in people...
Source: Arthritis Research UK - February 27, 2017 Category: Rheumatology Source Type: news

Baricitinib Might Offer Oral Alternative to Adalimumab in RA Baricitinib Might Offer Oral Alternative to Adalimumab in RA
A phase 3 trial in patients with rheumatoid arthritis who did not respond to methotrexate showed that the addition of baricitinib produced significant clinical improvements.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 22, 2017 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Arthritis Drugs Get Nod From EMA's CHMP Arthritis Drugs Get Nod From EMA's CHMP
Tofacitinib citrate (Xeljanz), two adalimumab (Humira) biosimilars, and one methotrexate hybrid get thumbs up from EMA committee.International Approvals (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - January 27, 2017 Category: Dermatology Tags: Rheumatology News Alert Source Type: news

Psoriasis and Arthritis Drugs Get Nod From EMA's CHMP Psoriasis and Arthritis Drugs Get Nod From EMA's CHMP
Tofacitinib citrate (Xeljanz), two adalimumab (Humira) biosimilars, and one methotrexate hybrid get thumbs up from EMA committee.International Approvals (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - January 27, 2017 Category: Drugs & Pharmacology Tags: Rheumatology News Alert Source Type: news

What can clinicians learn from therapeutic studies about the treatment of acute oral methotrexate poisoning? - Chan BS, Dawson AH, Buckley NA.
CONTEXT: Methotrexate (MTX) is an anti-folate drug that has been utilized in both malignant and chronic inflammatory conditions. Doctors are often concerned with a potential adverse outcome when managing patients with acute oral MTX poisoning given its pot... (Source: SafetyLit)
Source: SafetyLit - January 21, 2017 Category: Global & Universal Tags: Poisoning Source Type: news

Study Questions High-Dose Methotrexate in Early RA (CME/CE)
But formulation (MedPage Today) -- oral vs subcutaneous -- may make a difference (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - January 3, 2017 Category: Primary Care Source Type: news

Rheumatrex (Methotrexate Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 3, 2017 Category: Drugs & Pharmacology Source Type: news

Subcutaneous Methotrexate Safe, Effective for Psoriasis Subcutaneous Methotrexate Safe, Effective for Psoriasis
Subcutaneous methotrexate with an intensified 52-week dosing schedule should be considered for patients with psoriasis because of its favorable risk-benefit profile.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 30, 2016 Category: Consumer Health News Tags: Dermatology News Source Type: news

Teenager's psoriasis is cured by a cancer drug methotrexate
Elizabeth Wigmore, 18, from South Wales, has suffered from psoriasis - which caused her intense pain and bleeding - for four years. She now takes methotrexate each week to keep her symptoms at bay. (Source: the Mail online | Health)
Source: the Mail online | Health - December 13, 2016 Category: Consumer Health News Source Type: news

‘Turbocharged artificial intelligence’ could personalize combination therapy in pediatric leukemia
In this study, patient records were obtained on the dosing of 6-mercaptopurine and methotrexate, as well as on the corresponding  absolute neutrophil count, or levels of a subset of white blood cells called neutrophils that are vital for staving off potentially life-threatening infections. These records showed multiple instances where conventional chemotherapy doses caused deviations from acceptable neutrophil levels. Using the personalized medicine technology, individualized three-dimensional maps were generated to determine the optimal 6-mercaptopurine/methotrexate drug ratios.The team members found that their techn...
Source: UCLA Newsroom: Health Sciences - December 12, 2016 Category: Universities & Medical Training Source Type: news

Tocilizumab in RA With Inadequate Response to Methotrexate Tocilizumab in RA With Inadequate Response to Methotrexate
Does the addition of or switch to tocilizumab provide any additional benefits for rheumatoid arthritis patients who do not sufficiently respond to methotrexate alone?Annals of the Rheumatic Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 7, 2016 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Methotrexate Greatly Underprescribed for U.S. RA Patients (CME/CE)
(MedPage Today) -- The staple DMARD should be utilized longer, at higher doses, and via subcutaneous delivery, researchers say (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - December 2, 2016 Category: Geriatrics Source Type: news

Methotrexate ‘ Dramatically ’ Underused for RA Methotrexate ‘ Dramatically ’ Underused for RA
Methotrexate, the"anchor" drug for rheumatoid arthritis (RA), is"dramatically underutilized in clinical practice," researchers report.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - December 1, 2016 Category: Orthopaedics Tags: Rheumatology News Source Type: news

A case of methotrexate intoxication in a patient with psoriasis who drank beetroot juice during methotrexate treatment - G önül M, Keseroglu H, Hacınecipoğlu F.
We report a 50-year-old woman being treated with methotrexate for psoriasis who developed methotrexate intoxication... (Source: SafetyLit)
Source: SafetyLit - November 25, 2016 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news