PET/MRI detects brain injury in pediatric cancer survivors
PET/MRI could be a tool for diagnosing brain injury in young cancer survivors due to high-dose methotrexate treatment, according to pediatric radiologists at Stanford University in Stanford, CA. In a pilot study in 10 children and young adults, F-18 FDG-PET/MRI detected brain injury based on reductions in glucose metabolism and blood flow in specific brain areas. The imaging findings could facilitate earlier treatments in these patients, noted lead author Lucia Baratto, MD, and colleagues. “Using F-18 FDG-PET/MRI for assessing the cerebral impact of methotrexate therapy in pediatric cancer survivors holds the potential...
Source: AuntMinnie.com Headlines - April 8, 2024 Category: Radiology Authors: Will Morton Tags: Molecular Imaging Source Type: news

Abortion care limitations raise medicolegal concerns in IR
Interventional radiology (IR) specialists should be aware of shifting individual state laws on abortion so as to not be blindsided when called on to provide care to pregnant patients, a clinician in the field cautioned recently. In July last year, for instance, North Carolina joined 20 other states by passing new legislation that limits abortion based on timing, type, or other requirements, with 14 states having outright bans, noted Priya Mody, MD, an interventional radiologist in Chapel Hill. In a recent interview with AuntMinnie.com, she encouraged interventional radiologists to be aware of the nuances of these laws. ...
Source: AuntMinnie.com Headlines - April 3, 2024 Category: Radiology Authors: Will Morton Tags: Digital X-Ray Interventional Source Type: news

New Data on First-Line Psoriasis Drug'Very Reassuring'New Data on First-Line Psoriasis Drug'Very Reassuring '
A higher cumulative dose of methotrexate taken did not increase the risk for liver fibrosis, but excess weight, metabolic syndrome, and diabetes did.Medscape News UK (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - March 1, 2024 Category: Dermatology Tags: Dermatology Source Type: news

FAPI-PET predicts treatment response in patients with rheumatoid arthritis
In this study, they further analyzed data from 19 patients to determine whether FAPI-PET could help predict treatment responses. All of the patients had high or moderate disease activity and underwent PET/CT exams at baseline, as well as standard F-18 FDG PET/CT scans for comparison. Subsequent treatments included conventional DMARDs (including methotrexate, leflunomide, cyclophosphamide, and tripterygium wilfordii), and synthetic DMARDs (including etanercept, adalimumab, and Janus Kinase inhibitors). Six patients received additional prednisone, and six patients had nonsteroidal anti-inflammatory drugs.Representative Ga-6...
Source: AuntMinnie.com Headlines - January 9, 2024 Category: Radiology Authors: Will Morton Tags: Subspecialties Nuclear Radiology Source Type: news

Methotrexate Tied to Greater Risks for Older Patients With CKD
(MedPage Today) -- Older patients with chronic kidney disease (CKD) had greater risks for serious adverse events when starting on low-dose methotrexate rather than hydroxychloroquine, a propensity score-matched analysis found. About 60% of the... (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - November 28, 2023 Category: Dermatology Source Type: news

Methotrexate Carries Higher Risk for Older CKD Patients Methotrexate Carries Higher Risk for Older CKD Patients
Adverse event data showed an increased risk of myelosuppression, sepsis, pneumotoxic effects, or hepatotoxic effects.Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - November 27, 2023 Category: Allergy & Immunology Tags: Rheumatology News Source Type: news

Split-Dose Methotrexate Speeds RA Response Over Single Dose Split-Dose Methotrexate Speeds RA Response Over Single Dose
Compared with a single dose, more patients in the split-dose group had improved disease activity at 16 weeks, and fewer needed additional DMARDs, but the effect was not found at 24 weeks.Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - November 16, 2023 Category: Allergy & Immunology Tags: Rheumatology News Source Type: news

Methotrexate Reduces Pain in Hand Osteoarthritis With Synovitis
MONDAY, Nov. 6, 2023 -- For patients with hand osteoarthritis and synovitis, methotrexate has a potentially clinically meaningful effect on reducing pain, with no increase in adverse events, according to a study published online Oct. 12 in The... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 6, 2023 Category: Pharmaceuticals Source Type: news

Positive Trial of Methotrexate in Hand OA Has Modest Results Positive Trial of Methotrexate in Hand OA Has Modest Results
A randomized controlled trial of methotrexate in inflammatory hand OA demonstrated clinical benefit, suggesting a potential role for immunosuppression in a subset of patients with an inflammatory OA phenotype.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 30, 2023 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Treatment of a life-threatening dapsone intoxication - Veerman MH, van Gelder T, Sneijder R, Bethlehem C.
The case report describes a case of a severe dapsone (more than 200 tablets dapsone 100  mg) and mild methotrexate intoxication (10 tablets methotrexate 10 mg) as an attempt to commit suicide, resulting in severe cyanosis with elevation in methemoglobin con... (Source: SafetyLit)
Source: SafetyLit - October 26, 2023 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

AIIMS adds 63 drugs to free medicine list
"Sixty-three medicines have been added to the existing list," Dr M Srinivas said. Palbociclib, Dasatinib, Methotrexate, Trimazet, Magesterol Acetate and Leucovorin are among the medicines added to the list. Besides, injection regular insulin, injection NPH Insulin and injection Insulin Premix 30/70 will also be available free of cost. (Source: The Economic Times)
Source: The Economic Times - October 19, 2023 Category: Consumer Health News Source Type: news

Abatacept, Certolizumab: Best Biologics in Early RA? Abatacept, Certolizumab: Best Biologics in Early RA?
The study was the first head-to-head comparison of multiple biologics plus methotrexate vs active conventional DMARDs plus steroid bridging for the management of early rheumatoid arthritis.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 12, 2023 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Both Ciclosporin, Methotrexate Effective for Severe Eczema in Children
TUESDAY, Sept. 26, 2023 -- For children and young people with severe atopic dermatitis (AD), ciclosporin (CyA) and methotrexate (MTX) are both effective over 36 weeks, according to a study published online Sept. 19 in the British Journal of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 26, 2023 Category: Pharmaceuticals Source Type: news

Could Risk Stratifying MTX Users Lead to Testing Less Often? Could Risk Stratifying MTX Users Lead to Testing Less Often?
A new prognostic model accurately predicts a patient ’s risk of experiencing methotrexate toxicity, but more research is needed before clinical application, experts say.Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - July 28, 2023 Category: Allergy & Immunology Tags: Rheumatology News Source Type: news

MTX: Pediatric Inflammatory Skin Disease Guidelines Unveiled MTX: Pediatric Inflammatory Skin Disease Guidelines Unveiled
The guidelines include 46 evidence- and consensus-based recommendations about the use of methotrexate for inflammatory skin disease in pediatric patients developed by a committee of 23 experts.MDedge News (Source: Medscape Nurses Headlines)
Source: Medscape Nurses Headlines - July 5, 2023 Category: Nursing Tags: Dermatology News Source Type: news