Tocilizumab ± methotrexate not a cost-effective option in early RA
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - August 1, 2020 Category: Drugs & Pharmacology Source Type: news

Methotrexate Treat-and-Extend Tested for Vitreoretinopathy Methotrexate Treat-and-Extend Tested for Vitreoretinopathy
A methotrexate protocol that involves treat-and-extend dosing can be used to successfully treat proliferative vitreoretinopathy, a case series shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 27, 2020 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

Intraventricular Methotrexate Betters Survival in Medulloblastoma Intraventricular Methotrexate Betters Survival in Medulloblastoma
Intraventricular methotrexate and systemic chemotherapy produced favorable survival outcomes in patients with desmoplastic medulloblastoma and medulloblastoma with extensive nodularity in new study.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - July 20, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

TREMFYA ® (guselkumab) Approved by U.S. Food and Drug Administration as the First Selective Interleukin (IL)-23 Inhibitor for Active Psoriatic Arthritis
HORSHAM, PA, July 14, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) has approved TREMFYA® (guselkumab) for adult patients with active psoriatic arthritis (PsA), a chronic progressive disease characterized by painful joints and skin inflammation.[1],[2] TREMFYA is the first treatment approved for active PsA that selectively inhibits interleukin (IL)-23, a naturally occurring cytokine that is involved in normal inflammatory and immune responses associated with the symptoms of PsA. The safety and efficacy of TREMFYA in PsA have b...
Source: Johnson and Johnson - July 14, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Rheumatoid Arthritis Treatment Doesn't Harm Lungs: Study
MONDAY, July 13, 2020 -- Treatment with the immunosuppressant methotrexate does not raise the risk of lung disease among rheumatoid arthritis patients, two new studies claim. At least 5% to 10% of rheumatoid arthritis (RA) patients develop... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 13, 2020 Category: General Medicine Source Type: news

What Causes Early Pregnancy Vaginal Bleeding?
Discussion Pregnancy complications in early pregnancy range from mild to severe. They can include nausea and emesis which often is treated symptomatically, but can cause hyperemesis gravidarum and need hospitalization for intravenous fluids. Mild cramping and slight spotting are not uncommon. Some type of pregnancy bleeding is common with 20-40% of women experiencing it. Women who have early vaginal bleeding have a higher risk of later pregnancy complications. Pregnancy in adolescents is about 10% of all pregnancies. Adolescent pregnancy can be associated with various problems including higher rates of threatened aborti...
Source: PediatricEducation.org - July 13, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Upadacitinib Beats Methotrexate in Early Rheumatoid Arthritis
WEDNESDAY, July 8, 2020 -- Upadacitinib monotherapy results in improved outcomes versus methotrexate for patients with predominantly early rheumatoid arthritis, according to a study published online July 8 in Arthritis& Rheumatology. Ronald van... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 8, 2020 Category: Pharmaceuticals Source Type: news

Started Early, Drug Combo Eases Fatigue of Rheumatoid Arthritis: Study
FRIDAY, June 26, 2020 -- Early and intensive treatment with methotrexate and prednisone can ease fatigue in people with rheumatoid arthritis (RA), according to a new study. RA causes chronically inflamed joints and that inflammation can lead to... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 26, 2020 Category: General Medicine Source Type: news

Janssen Announces Discontinuation of Phase 3 LOTUS Study Evaluating Ustekinumab in Systemic Lupus Erythematosus
SPRING HOUSE, PENNSYLVANIA, June 26, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today its decision to discontinue the Phase 3 LOTUS study of STELARA® (ustekinumab) in Systemic Lupus Erythematosus (SLE) due to lack of efficacy in SLE.The decision is based on data from a pre-planned interim efficacy analysis. Interim safety findings were consistent with the known safety profile of STELARA, and no new safety signals were identified. Investigators, study participants and health authorities have been informed of the decision. The company intends to thoroughly analyze the totality of...
Source: Johnson and Johnson - June 26, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Mesothelioma Chemoperfusion Trial Shows Impressive Results
Study statistics show the benefits of the novel transarterial chemoperfusion treatment being used successfully at the Moffitt Cancer Center in Tampa for patients with relapsed pleural mesothelioma. Russell Lamkins — working on the roof of a neighbor’s house — shows them even better. He is living proof. This latest mesothelioma treatment has potential. Lamkins, 73, was first diagnosed with mesothelioma in 2014. He was the second patient to enroll in the mesothelioma clinical trial in March 2016, soon after standard-of-care chemotherapy and immunotherapy had failed him. “At that point, I had no choice...
Source: Asbestos and Mesothelioma News - June 22, 2020 Category: Environmental Health Authors: Fran Mannino Source Type: news

No Link Between Methotrexate, Interstitial Lung Disease in RA No Link Between Methotrexate, Interstitial Lung Disease in RA
Patients with rheumatoid arthritis are at elevated risk for interstitial lung disease, but methotrexate does not accentuate that risk and may be protective, new data show.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 11, 2020 Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news

TNF Inhibitor Plus Methotrexate Surpassed Monotherapy in PsA TNF Inhibitor Plus Methotrexate Surpassed Monotherapy in PsA
The addition of a TNF inhibitor to the treatment regimen of patients with psoriatic arthritis (PsA) improves the achievement of minimal disease activity, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 10, 2020 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Janssen Announces Submission of Two Applications to U.S. FDA Seeking Approval of SIMPONI ARIA ® (golimumab) for the Treatment of Polyarticular Juvenile Idiopathic Arthritis and Juvenile Psoriatic Arthritis
HORSHAM, PA, April 24, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the submission of two supplemental Biologics License Applications (sBLA) to the U.S. Food and Drug Administration (FDA) seeking approval of SIMPONI ARIA® (golimumab) for the treatment of polyarticular juvenile idiopathic arthritis (pJIA) and juvenile psoriatic arthritis (jPsA), in patients two years of age and older in combination with methotrexate. If approved for these indications, SIMPONI ARIA would be the first anti-tumor necrosis factor (TNF)-alpha biologic agent administered by intravenous infusion av...
Source: Johnson and Johnson - April 24, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

IBD and COVID-19: Hold Certain Meds, AGA Advises
Patients with inflammatory bowel disease (IBD) who develop COVID-19 should stop taking thiopurines, methotrexate, tofacitinib, and biological therapies during the viral illness, according to the AGA. (Source: WebMD Health)
Source: WebMD Health - April 14, 2020 Category: Consumer Health News Source Type: news

Toxicity Due to Combination of Leflunomide and Methotrexate: Toxicity Due to Combination of Leflunomide and Methotrexate:
Therapy with methotrexate and leflunomide in a patient with active rheumatoid arthritis produced an unusual combination of drug-induced thrombotic microangiopathy and liver injury.Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 14, 2020 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

Methotrexate Treatment of Chronic Chikungunya Arthritis Methotrexate Treatment of Chronic Chikungunya Arthritis
Is methotrexate a safe and effective therapeutic option for chikungunya-related chronic arthritis? The authors report their experience with this treatment.Journal of Clinical Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 14, 2020 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

IBD and COVID-19: Hold Certain Meds, AGA Advises IBD and COVID-19: Hold Certain Meds, AGA Advises
Patients with inflammatory bowel disease (IBD) who develop COVID-19 should stop taking thiopurines, methotrexate, tofacitinib, and biological therapies during the viral illness, according to the AGA.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - April 14, 2020 Category: Gastroenterology Tags: Gastroenterology News Source Type: news

Methotrexate vs curettage for low-risk gestational trophoblastic neoplasia
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - April 1, 2020 Category: Drugs & Pharmacology Source Type: news

Roche initiates Phase III clinical trial of Actemra/RoActemra in hospitalised patients with severe COVID-19 pneumonia
Basel, 19 March 2020- Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced   we are working with the Food& Drug Administration (FDA) to initiate a randomised, double-blind, placebo-controlled Phase III clinical trial in collaboration with the Biomedical Advanced Research and Development Authority (BARDA), a part of the US Health and Human Services Office of the Assistant Secretary for Preparedness and Response (ASPR), to evaluate the safety and efficacy of Actemra ®/RoActemra® (tocilizumab) plus standard of care in hospitalised adult patients with severe COVID-19 pneumonia compared to placebo plus standard o...
Source: Roche Media News - March 19, 2020 Category: Pharmaceuticals Source Type: news

Brief Update on Dermatologic Uses of Methotrexate Brief Update on Dermatologic Uses of Methotrexate
This review explores established and emerging clinical indications for methotrexate in dermatological conditions, including psoriasis, blistering diseases, chronic urticaria, slceroderma, and more.Skin Therapy Letter (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 24, 2020 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Study Probes Side Effects of Methotrexate, Used for Psoriasis, Rheumatoid Arthritis
Title: Study Probes Side Effects of Methotrexate, Used for Psoriasis, Rheumatoid ArthritisCategory: Health NewsCreated: 2/18/2020 12:00:00 AMLast Editorial Review: 2/19/2020 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - February 19, 2020 Category: Rheumatology Source Type: news

Risk for Adverse Events Up With Low-Dose Methotrexate
TUESDAY, Feb. 18, 2020 -- Use of low-dose methotrexate (LD-MTX) is associated with increased risks for adverse events (AEs), including skin cancer, and gastrointestinal, pulmonary, infectious, and hematologic AEs, according to research published... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 18, 2020 Category: Pharmaceuticals Source Type: news

Study Probes Side Effects of Long-Used Methotrexate
People who took methotrexate had small-to-moderate increases in risks for skin cancer, infections, and gastrointestinal, lung and blood problems, according to the study published Feb. 17 in the Annals of Internal Medicine. (Source: WebMD Health)
Source: WebMD Health - February 18, 2020 Category: Consumer Health News Source Type: news

Study Probes Side Effects of Methotrexate, Used for Psoriasis, Rheumatoid Arthritis
TUESDAY, Feb. 18, 2020 -- Many Americans battling autoimmune illnesses such as rheumatoid arthritis or psoriasis turn to a long-used drug, methotrexate, for relief. But until now there's been little comprehensive research on side effects tied to... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 18, 2020 Category: General Medicine Source Type: news

Biologics Tied to Greater Reduction in Pediatric Psoriasis
MONDAY, Feb. 10, 2020 -- Biologics seem to be associated with greater reduction in psoriasis severity scores and higher drug survival rates than methotrexate in pediatric patients treated in a real-world setting, according to a study published... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 10, 2020 Category: Pharmaceuticals Source Type: news

Reasons for Methotrexate Non-Adherence in Patients With RA Reasons for Methotrexate Non-Adherence in Patients With RA
Why might certain rheumatoid arthritis patients choose not to adhere to methotrexate therapy? Could certain factors predict non-adherence?Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 24, 2020 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Otrexup PFS (Methotrexate Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 6, 2020 Category: Drugs & Pharmacology Source Type: news

Adalimumab in Pediatric Patients With Severe Plaque Psoriasis Adalimumab in Pediatric Patients With Severe Plaque Psoriasis
This analysis reports results from the first RCT comparing the efficacy and safety of the biologic adalimumab with methotrexate for severe plaque psoriasis in children.The British Journal of Dermatology (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - December 27, 2019 Category: Allergy & Immunology Tags: Dermatology Journal Article Source Type: news

RediTrex (Methotrexate Injection) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 11, 2019 Category: Drugs & Pharmacology Source Type: news

FDA Approves RediTrex (methotrexate) for Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Psoriasis
NASHVILLE, Tenn., Dec. 2, 2019 /PRNewswire/ -- Cumberland Pharmaceuticals Inc. (NASDAQ: CPIX), a specialty pharmaceutical company, today announced that it has received approval from the U.S. Food and Drug Administration (FDA) for RediTrex, its new... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - December 2, 2019 Category: Drugs & Pharmacology Source Type: news

Cumberland Pharmaceuticals Receives FDA Approval for RediTrex(TM) Product Line
NASHVILLE, Tenn., Dec. 2, 2019 -- (Healthcare Sales & Marketing Network) -- Cumberland Pharmaceuticals Inc. (NASDAQ: CPIX), a specialty pharmaceutical company, today announced that it has received approval from the U.S. Food and Drug Administration (FDA) ... Biopharmaceuticals, FDA Cumberland Pharmaceuticals, RediTrex, methotrexate, arthritis (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - December 2, 2019 Category: Pharmaceuticals Source Type: news

Hormonal Used in Place of Chemotherapy for Ectopic Pregnancy Hormonal Used in Place of Chemotherapy for Ectopic Pregnancy
An aromatase inhibitor is a safe and effective way to end an ectopic pregnancy, with a better safety profile than methotrexate,'breakthrough'results from a small study show.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 25, 2019 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news

Three-Drug Palliative Chemotherapy Regimen Shows Promise for Advanced Oral Cancer
The methotrexate-based regimen proved to lengthen survival and improve quality of life among patients with platinum-resistant oral cancer. (Source: CancerNetwork)
Source: CancerNetwork - October 3, 2019 Category: Cancer & Oncology Authors: Seth Augenstein Source Type: news

Two commonly used drugs for uveitis perform equally well
The drug methotrexate performed as well as the more expensive mycophenolate mofetil for treating uveitis, a form of eye inflammation. The findings provide new guidance for treatment. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - September 23, 2019 Category: Consumer Health News Source Type: news

Anti-Fungal Prophylaxis Using Intermediate Dose Ambisome Is Associated with Delayed Methotrexate Clearance in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - September 22, 2019 Category: Respiratory Medicine Authors: MeganB Source Type: news

Mycophenolate Mofetil Does Not Top MTX in Noninfectious Uveitis
WEDNESDAY, Sept. 11, 2019 -- For adults with noninfectious uveitis, mycophenolate mofetil is not associated with superior control of inflammation compared with methotrexate, according to a study published in the Sept. 10 issue of the Journal of the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 11, 2019 Category: Pharmaceuticals Source Type: news

Two commonly used uveitis drugs perform similarly in NIH-funded clinical trial
Methotrexate was more effective than mycophenolate mofetil at treating severe forms of the eye disease (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - September 10, 2019 Category: American Health Source Type: news

Methotrexate-Biologics Combo Provides Better Outcomes in Early Rheumatoid Arthritis Methotrexate-Biologics Combo Provides Better Outcomes in Early Rheumatoid Arthritis
The combination of methotrexate with TNF inhibitors or non-TNF biologics provides better outcomes than methotrexate monotherapy in adults with early rheumatoid arthritis (RA), according to a new systematic review and network meta-analysis.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 29, 2019 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Combo Tx May Improve Disease Control for Some in Early RA
TUESDAY, Aug. 27, 2019 -- For patients with early rheumatoid arthritis (RA) and high disease activity, the combination of a tumor necrosis factor (TNF) or non-TNF biologic with methotrexate improves disease control, remission, and functional... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 27, 2019 Category: Pharmaceuticals Source Type: news

Effectiveness of Nonbiologic Systemic Therapies for Psoriasis Effectiveness of Nonbiologic Systemic Therapies for Psoriasis
This study evaluated the real-world persistence and/or effectiveness of acitretin, ciclosporin, fumaric acid esters, and methotrexate in adult patients with moderate-to-severe psoriasis.The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 20, 2019 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

FDA Approves Upadacitinib (Rinvoq), New JAK Inhibitor for RA FDA Approves Upadacitinib (Rinvoq), New JAK Inhibitor for RA
Upadacitinib is for adults with moderately to severely active rheumatoid arthritis who fail to respond adequately or are intolerant to methotrexate.FDA Approvals (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - August 19, 2019 Category: Allergy & Immunology Tags: Rheumatology News Alert Source Type: news

PRAC Proposes New Measures to Avoid Methotrexate Dosing Errors PRAC Proposes New Measures to Avoid Methotrexate Dosing Errors
The measures aim to prevent misunderstandings of the dosing schedule that have led to patients taking the medicine daily instead of weekly for inflammatory diseases.News Alerts (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - July 12, 2019 Category: Allergy & Immunology Tags: Rheumatology News Alert Source Type: news

Otrexup PFS (Methotrexate Injection) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 9, 2019 Category: Drugs & Pharmacology Source Type: news

Acute versus chronic methotrexate poisoning; a cross-sectional study - Ahmadzadeh A, Zamani N, Hassanian-Moghaddam H, Hadeiy SK, Parhizgar P.
BACKGROUND: Data is limited on comparison of acute and chronic methotrexate (MTX) poisoning. Methotrexate is an anti-folate drug that may be prescribed in some malignant or chronic inflammatory conditions. The aim of the current study was to compare signs ... (Source: SafetyLit)
Source: SafetyLit - July 6, 2019 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

Medical News Today: How does methotrexate affect pregnancy?
It is not safe to take methotrexate during pregnancy. The drug affects folic acid levels in the body and can lead to birth abnormalities. In this article, we look at the effects of taking methotrexate during conception or pregnancy, how to stay safe, and alternative medications. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 25, 2019 Category: Consumer Health News Tags: Rheumatoid Arthritis Source Type: news

Medical News Today: Is chemotherapy effective for rheumatoid arthritis?
Chemotherapy drugs, such as methotrexate, are one of the first-line treatments for people with rheumatoid arthritis. These drugs can help relieve symptoms and prevent further joint damage. However, they can cause a number of side effects, and doctors will closely monitor people on these drugs. Learn more here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 20, 2019 Category: Consumer Health News Tags: Rheumatoid Arthritis Source Type: news

Infection Risk Lower With Certain Psoriasis Treatments
MONDAY, May 13, 2019 -- For patients with psoriasis treated with systemic medications, the risk for serious infection is reduced for new users of apremilast, etanercept, and ustekinumab versus methotrexate, according to a study published online May... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 13, 2019 Category: Pharmaceuticals Source Type: news

Why Methotrexate Should Be a Prerequisite to Biologics in RA Why Methotrexate Should Be a Prerequisite to Biologics in RA
This editorial explores the rationale behind considering subcutaneous methotrexate prior to recommending biologic therapies in rheumatoid arthritis.Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 23, 2019 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

PsA: Where Does Methotrexate Fit In? (CME/CE)
(MedPage Today) -- Phase III, placebo-controlled study shows adding methotrexate only benefits patients with greater psoriatic symptoms (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - February 26, 2019 Category: Dermatology Source Type: news

Psoriatic Arthritis: What Role for Methotrexate?
(MedPage Today) -- Trial data indicates it helps with some symptoms, for others not so much (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - February 18, 2019 Category: Dermatology Source Type: news