Biologics Tied to Greater Reduction in Pediatric Psoriasis
MONDAY, Feb. 10, 2020 -- Biologics seem to be associated with greater reduction in psoriasis severity scores and higher drug survival rates than methotrexate in pediatric patients treated in a real-world setting, according to a study published... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 10, 2020 Category: Pharmaceuticals Source Type: news

Reasons for Methotrexate Non-Adherence in Patients With RA Reasons for Methotrexate Non-Adherence in Patients With RA
Why might certain rheumatoid arthritis patients choose not to adhere to methotrexate therapy? Could certain factors predict non-adherence?Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 24, 2020 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Otrexup PFS (Methotrexate Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 6, 2020 Category: Drugs & Pharmacology Source Type: news

Adalimumab in Pediatric Patients With Severe Plaque Psoriasis Adalimumab in Pediatric Patients With Severe Plaque Psoriasis
This analysis reports results from the first RCT comparing the efficacy and safety of the biologic adalimumab with methotrexate for severe plaque psoriasis in children.The British Journal of Dermatology (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - December 27, 2019 Category: Allergy & Immunology Tags: Dermatology Journal Article Source Type: news

RediTrex (Methotrexate Injection) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 11, 2019 Category: Drugs & Pharmacology Source Type: news

FDA Approves RediTrex (methotrexate) for Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Psoriasis
NASHVILLE, Tenn., Dec. 2, 2019 /PRNewswire/ -- Cumberland Pharmaceuticals Inc. (NASDAQ: CPIX), a specialty pharmaceutical company, today announced that it has received approval from the U.S. Food and Drug Administration (FDA) for RediTrex, its new... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - December 2, 2019 Category: Drugs & Pharmacology Source Type: news

Cumberland Pharmaceuticals Receives FDA Approval for RediTrex(TM) Product Line
NASHVILLE, Tenn., Dec. 2, 2019 -- (Healthcare Sales & Marketing Network) -- Cumberland Pharmaceuticals Inc. (NASDAQ: CPIX), a specialty pharmaceutical company, today announced that it has received approval from the U.S. Food and Drug Administration (FDA) ... Biopharmaceuticals, FDA Cumberland Pharmaceuticals, RediTrex, methotrexate, arthritis (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - December 2, 2019 Category: Pharmaceuticals Source Type: news

Hormonal Used in Place of Chemotherapy for Ectopic Pregnancy Hormonal Used in Place of Chemotherapy for Ectopic Pregnancy
An aromatase inhibitor is a safe and effective way to end an ectopic pregnancy, with a better safety profile than methotrexate,'breakthrough'results from a small study show.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 25, 2019 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news

Three-Drug Palliative Chemotherapy Regimen Shows Promise for Advanced Oral Cancer
The methotrexate-based regimen proved to lengthen survival and improve quality of life among patients with platinum-resistant oral cancer. (Source: CancerNetwork)
Source: CancerNetwork - October 3, 2019 Category: Cancer & Oncology Authors: Seth Augenstein Source Type: news

Two commonly used drugs for uveitis perform equally well
The drug methotrexate performed as well as the more expensive mycophenolate mofetil for treating uveitis, a form of eye inflammation. The findings provide new guidance for treatment. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - September 23, 2019 Category: Consumer Health News Source Type: news

Anti-Fungal Prophylaxis Using Intermediate Dose Ambisome Is Associated with Delayed Methotrexate Clearance in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - September 22, 2019 Category: Respiratory Medicine Authors: MeganB Source Type: news

Mycophenolate Mofetil Does Not Top MTX in Noninfectious Uveitis
WEDNESDAY, Sept. 11, 2019 -- For adults with noninfectious uveitis, mycophenolate mofetil is not associated with superior control of inflammation compared with methotrexate, according to a study published in the Sept. 10 issue of the Journal of the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 11, 2019 Category: Pharmaceuticals Source Type: news

Two commonly used uveitis drugs perform similarly in NIH-funded clinical trial
Methotrexate was more effective than mycophenolate mofetil at treating severe forms of the eye disease (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - September 10, 2019 Category: American Health Source Type: news

Methotrexate-Biologics Combo Provides Better Outcomes in Early Rheumatoid Arthritis Methotrexate-Biologics Combo Provides Better Outcomes in Early Rheumatoid Arthritis
The combination of methotrexate with TNF inhibitors or non-TNF biologics provides better outcomes than methotrexate monotherapy in adults with early rheumatoid arthritis (RA), according to a new systematic review and network meta-analysis.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 29, 2019 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Combo Tx May Improve Disease Control for Some in Early RA
TUESDAY, Aug. 27, 2019 -- For patients with early rheumatoid arthritis (RA) and high disease activity, the combination of a tumor necrosis factor (TNF) or non-TNF biologic with methotrexate improves disease control, remission, and functional... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 27, 2019 Category: Pharmaceuticals Source Type: news

Effectiveness of Nonbiologic Systemic Therapies for Psoriasis Effectiveness of Nonbiologic Systemic Therapies for Psoriasis
This study evaluated the real-world persistence and/or effectiveness of acitretin, ciclosporin, fumaric acid esters, and methotrexate in adult patients with moderate-to-severe psoriasis.The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 20, 2019 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

FDA Approves Upadacitinib (Rinvoq), New JAK Inhibitor for RA FDA Approves Upadacitinib (Rinvoq), New JAK Inhibitor for RA
Upadacitinib is for adults with moderately to severely active rheumatoid arthritis who fail to respond adequately or are intolerant to methotrexate.FDA Approvals (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - August 19, 2019 Category: Allergy & Immunology Tags: Rheumatology News Alert Source Type: news

PRAC Proposes New Measures to Avoid Methotrexate Dosing Errors PRAC Proposes New Measures to Avoid Methotrexate Dosing Errors
The measures aim to prevent misunderstandings of the dosing schedule that have led to patients taking the medicine daily instead of weekly for inflammatory diseases.News Alerts (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - July 12, 2019 Category: Allergy & Immunology Tags: Rheumatology News Alert Source Type: news

Otrexup PFS (Methotrexate Injection) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 9, 2019 Category: Drugs & Pharmacology Source Type: news

Acute versus chronic methotrexate poisoning; a cross-sectional study - Ahmadzadeh A, Zamani N, Hassanian-Moghaddam H, Hadeiy SK, Parhizgar P.
BACKGROUND: Data is limited on comparison of acute and chronic methotrexate (MTX) poisoning. Methotrexate is an anti-folate drug that may be prescribed in some malignant or chronic inflammatory conditions. The aim of the current study was to compare signs ... (Source: SafetyLit)
Source: SafetyLit - July 6, 2019 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

Medical News Today: How does methotrexate affect pregnancy?
It is not safe to take methotrexate during pregnancy. The drug affects folic acid levels in the body and can lead to birth abnormalities. In this article, we look at the effects of taking methotrexate during conception or pregnancy, how to stay safe, and alternative medications. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 25, 2019 Category: Consumer Health News Tags: Rheumatoid Arthritis Source Type: news

Medical News Today: Is chemotherapy effective for rheumatoid arthritis?
Chemotherapy drugs, such as methotrexate, are one of the first-line treatments for people with rheumatoid arthritis. These drugs can help relieve symptoms and prevent further joint damage. However, they can cause a number of side effects, and doctors will closely monitor people on these drugs. Learn more here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 20, 2019 Category: Consumer Health News Tags: Rheumatoid Arthritis Source Type: news

Infection Risk Lower With Certain Psoriasis Treatments
MONDAY, May 13, 2019 -- For patients with psoriasis treated with systemic medications, the risk for serious infection is reduced for new users of apremilast, etanercept, and ustekinumab versus methotrexate, according to a study published online May... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 13, 2019 Category: Pharmaceuticals Source Type: news

Why Methotrexate Should Be a Prerequisite to Biologics in RA Why Methotrexate Should Be a Prerequisite to Biologics in RA
This editorial explores the rationale behind considering subcutaneous methotrexate prior to recommending biologic therapies in rheumatoid arthritis.Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 23, 2019 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

PsA: Where Does Methotrexate Fit In? (CME/CE)
(MedPage Today) -- Phase III, placebo-controlled study shows adding methotrexate only benefits patients with greater psoriatic symptoms (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - February 26, 2019 Category: Dermatology Source Type: news

Psoriatic Arthritis: What Role for Methotrexate?
(MedPage Today) -- Trial data indicates it helps with some symptoms, for others not so much (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - February 18, 2019 Category: Dermatology Source Type: news

Methotrexate Added to Biologic Eases Inflamed Skin Methotrexate Added to Biologic Eases Inflamed Skin
The combination of methotrexate and anti-TNF therapy can improve clinical response in patients with severe hidradenitis suppurativa, first results from a new study demonstrate.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 8, 2019 Category: Consumer Health News Tags: Dermatology News Source Type: news

Tofacitinib Benefits Sustained for Two Years in Patients With RA
MONDAY, Feb. 4, 2019 -- The clinical benefits of tofacitinib in combination with methotrexate are sustained over two years among patients with rheumatoid arthritis (RA), according to a study published online Jan. 22 in Arthritis&... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 4, 2019 Category: Pharmaceuticals Source Type: news

EMedHome's Clinical Pearl: Risk of Methotrexate Failure for Ectopic Pregnancy
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - February 1, 2019 Category: Emergency Medicine Tags: EMedHome's Clinical Pearl Source Type: news

Methotrexate Well Tolerated, Effective for Psoriasis in Chinese
THURSDAY, Jan. 31, 2019 -- Methotrexate is well tolerated and effective for psoriasis in a Chinese population and is more effective for those without psoriatic arthritis, according to a study published online Jan. 30 in JAMA Dermatology. Kexiang... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 31, 2019 Category: Pharmaceuticals Source Type: news

GI Case Quiz: Ileocolonic Anastomosis a Success, New Symptoms Arise
What might cause severe abdominal bloating& diarrhea 3 years after ileocolonic resection and adalimumab/methotrexate treatment?   (Source: ConsultantLive)
Source: ConsultantLive - January 30, 2019 Category: Internal Medicine Authors: Ted W. James, MD Tags: Gastrointestinal Disorders Source Type: news

MTX vs. Ciclosporin for Severe Atopic Eczema in Children MTX vs. Ciclosporin for Severe Atopic Eczema in Children
This study aims to compare the effectiveness, safety, cost-effectiveness and impact on patient's quality of life of methotrexate vs. ciclosporin for refractory atopic eczema in children.The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 28, 2019 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Does Methotrexate Work in Giant Cell Arteritis?
(MedPage Today) -- Methotrexate add-on to glucocorticoid decreased rate of subsequent relapse by nearly two-fold (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - January 26, 2019 Category: Primary Care Source Type: news

methotrexate (Rheumatrex, Trexall)
Title: methotrexate (Rheumatrex, Trexall)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 12/14/2018 12:00:00 AM (Source: MedicineNet Skin General)
Source: MedicineNet Skin General - December 14, 2018 Category: Dermatology Source Type: news

'Chemo brain' caused by malfunction in three types of brain cells, Stanford study finds
(Stanford Medicine) In a new study explaining the cellular mechanisms behind cognitive impairment from chemotherapy, scientists at the Stanford University School of Medicine have demonstrated that a widely used chemotherapy drug, methotrexate, causes a complex set of problems in three major cell types within the brain's white matter. The study, which will be published online Dec. 6 in Cell, also identifies a potential remedy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 6, 2018 Category: Cancer & Oncology Source Type: news

CIRT: Methotrexate Fails to Cut CV Events CIRT: Methotrexate Fails to Cut CV Events
Though negative, the results provide vital information on the underlying biology that connects inflammation with cardiovascular disease, experts say.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 11, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news

AHA: Targeting Inflammation With Methotrexate Flops for CV Prevention
(MedPage Today) -- CIRT trial disappoints after CANTOS'win for the inflammatory hypothesis (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 10, 2018 Category: Cardiology Source Type: news

Low-Dose Methotrexate Does Not Reduce Risk of Cardiovascular Events
Inexpensive generic drug neither inhibited critical inflammatory pathways nor reduced rates of heart attack, stroke and cardiovascular death (Source: BWH News)
Source: BWH News - November 10, 2018 Category: Hospital Management Source Type: news

Medical News Today: Methotrexate and folic acid for rheumatoid arthritis
Doctors sometimes prescribe methotrexate for rheumatoid arthritis (RA), but it can lead to folic acid deficiencies. Learn more about managing this and other side effects. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 29, 2018 Category: Consumer Health News Tags: Rheumatoid Arthritis Source Type: news

First Head-to-Head Trial of a TNF Inhibitor Versus Methotrexate Monotherapy in Psoriatic Arthritis Shows ENBREL ® (Etanercept) Monotherapy and Combination Therapy Both Superior to Methotrexate
Results From Head-To-Head Phase 3 SEAM-PsA Study Assessing ENBREL and Methotrexate Regimens in Patients With Psoriatic Arthritis Presented at 2018 ACR/ARHP Annual Meeting Additional Phase 3b Results Show Modified ENBREL Formulation Associated With Significantly Lower Mean Injection Site Pain Versus Prior Formulation Data Presentations Result of Continued Dedication to Evaluate Optimal Use of ENBREL THOUSAND OAKS, Calif., Oct. 24, 2018 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that positive results from the Phase 3 SEAM-PsA study comparing the efficacy of Enbrel® (etanercept) monotherapy and ENBREL pl...
Source: Amgen News Release - October 24, 2018 Category: Pharmaceuticals Tags: Uncategorized Source Type: news

AbbVie rheumatoid arthritis drug succeeds in late stage trial
AbbVie Inc on Tuesday said its experimental rheumatoid arthritis (RA) treatment showed significant improvement in physical function, pain and quality of life compared with the commonly prescribed generic drug methotrexate in a late stage clinical trial. (Source: Reuters: Health)
Source: Reuters: Health - October 23, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

In Peripheral Spondyloarthritis, Early Biologic Needed In Peripheral Spondyloarthritis, Early Biologic Needed
New data from the CRESPA extension study show that the addition of methotrexate during biologic tapering has no significant effect on remission in peripheral spondyloarthritis.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 11, 2018 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Methotrexate Effective in Subcutaneous Psoriasis
(MedPage Today) -- Over 40% of patients achieved PASI 75 response in 16-week trial (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - September 15, 2018 Category: Dermatology Source Type: news

Subq Methotrexate Effective in Psoriasis
(MedPage Today) -- Over 40% of patients achieved PASI 75 response in 16-week trial (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - September 15, 2018 Category: Dermatology Source Type: news

Text Message: Take Your Methotrexate! (CME/CE)
(MedPage Today) -- Pilot program found better adherence in rheumatoid arthritis patients with weekly reminders (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - September 14, 2018 Category: Rheumatology Source Type: news

Double the Risk for Neurotoxicity for Hispanic Kids From ALL Rx Double the Risk for Neurotoxicity for Hispanic Kids From ALL Rx
Minority children, notably Hispanics, are more susceptible to developing methotrexate-induced neurotoxicity than non-Hispanic children during treatment for acute lymphoblastic leukemia (ALL).Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 12, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Subcutaneous Methotrexate in Moderate-to-Severe Psoriasis Subcutaneous Methotrexate in Moderate-to-Severe Psoriasis
A new study investigates the efficacy of an intensified two-step dosing schedule of subcutaneous methotrexate in patients with moderate-to-severe chronic plaque psoriasis.The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 3, 2018 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Younger Age, Active Disease Predictors of Methotrexate Failure in Patients With Inflammatory Polyarthritis
No abstract available (Source: Lippincott's Bone and Joint Newsletter)
Source: Lippincott's Bone and Joint Newsletter - August 16, 2018 Category: Orthopaedics Tags: Trends and Innovations Source Type: news

Consensus Guidelines for Methotrexate in JIA
(MedPage Today) -- Here are the 10 recommendations (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - August 4, 2018 Category: Pediatrics Source Type: news