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JIA Flares Fewer with Longer Inactive Disease
(MedPage Today) -- Study can inform decision-making on stopping methotrexate (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - February 21, 2018 Category: Pediatrics Source Type: news

Etanercept Biosimilar Is Effective, Well-tolerated for Rheumatoid Arthritis Etanercept Biosimilar Is Effective, Well-tolerated for Rheumatoid Arthritis
The biosimilar LBEC0101 is equivalent to etanercept (Enbrel) in treating patients with rheumatoid arthritis (RA) who respond inadequately to methotrexate, according to researchers from Korea and Japan.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - February 20, 2018 Category: Orthopaedics Tags: Rheumatology News Source Type: news

Methotrexate May Help in Chronic Viral Arthritis (CME/CE)
(MedPage Today) -- Some benefits seen after chikungunya virus infection (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - January 26, 2018 Category: Infectious Diseases Source Type: news

Methotrexate Injection (New - Discontinuation)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - January 25, 2018 Category: Drugs & Pharmacology Source Type: news

6,000-year-old track record for healing leaky gut
When I was traveling in India, I had the privilege of studying Ayurvedic medicine with traditional Master Healers. Surrounded by lakes, oceans and mountains, Kerala, India, is the birthplace of Ayurveda medicine. My plane landed in Mumbai. From there, I made the 800-mile trip to Kerala down on the southwestern-most tip of the Indian peninsula. With origins dating back 6,000 years, Kerala is the birthplace of Ayurvedic medicine. I spent a lot of time at the AyurMana or “ancient healing house.” This is the oldest existing school of Ayurvedic medicine in the world. It was there that I observed how quickly...
Source: Al Sears, MD Natural Remedies - January 17, 2018 Category: Complementary Medicine Authors: Cathy Card Tags: Health Natural Cures anxiety arthritis Cancer celiac disease chronic fatigue depression diabetes digestive issues fibromyalgia leaky gut multiple sclerosis schizophrenia Source Type: news

High-Dose vs Low-Dose Methotrexate in Patients With RA High-Dose vs Low-Dose Methotrexate in Patients With RA
Could higher doses of methotrexate offer additional benefits to patients with early rheumatoid arthritis?Arthritis Research & Therapy (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 9, 2018 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Low-dose Methotrexate: Determinants for Adverse Events Low-dose Methotrexate: Determinants for Adverse Events
What are the relative risks of adverse events in patients exposed to low-dose methotrexate vs. placebo, and what factors might predispose patients to these events?The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 26, 2017 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

FDA OKs Tofacitinib (Xeljanz) for Active Psoriatic Arthritis FDA OKs Tofacitinib (Xeljanz) for Active Psoriatic Arthritis
The JAK inhibitor is indicated for patients who have failed to respond adequately or are intolerant to methotrexate or other disease-modifying antirheumatic drugs.FDA Approvals (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - December 18, 2017 Category: Allergy & Immunology Tags: Rheumatology News Alert Source Type: news

MTX Doubles Hepatotoxicity Risk in Psoriasis Patients
(MedPage Today) -- But methotrexate does not increase risk of liver disease in patients with rheumatoid arthritis (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - November 25, 2017 Category: Gastroenterology Source Type: news

Break From Methotrexate Boosts Flu Shot Efficacy in RA
With a drug holiday, patients with rheumatoid arthritis could improve their response to influenza vaccinations without increasing disease activity. (Source: CancerNetwork)
Source: CancerNetwork - November 14, 2017 Category: Cancer & Oncology Authors: Mariah Zebrowski Leach, JD, MS Tags: Rheumatoid Arthritis Source Type: news

Break From Methotrexate Boosts Flu Shot Efficacy in RA
With a drug holiday, patients with rheumatoid arthritis could improve their response to influenza vaccinations without increasing disease activity. (Source: ConsultantLive)
Source: ConsultantLive - November 14, 2017 Category: Internal Medicine Authors: Mariah Zebrowski Leach, JD, MS Tags: Rheumatoid Arthritis Source Type: news

Baricitinib Eases Rheumatoid Arthritis Pain Baricitinib Eases Rheumatoid Arthritis Pain
The JAK inhibitor reduced pain in rheumatoid arthritis patients refractory to methotrexate more than a TNF inhibitor, a new analysis of RA-BEAM data shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 8, 2017 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Stop Methotrexate in RA Patients for 2 Weeks After Flu Shot Stop Methotrexate in RA Patients for 2 Weeks After Flu Shot
A temporary suspension of methotrexate boosts the immune response to flu vaccination with no increase in rheumatoid arthritis (RA) disease activity, a randomized clinical trial shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 5, 2017 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Methotrexate Sodium Injection (New - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - October 12, 2017 Category: Drugs & Pharmacology Source Type: news

Hurricane Damage in Puerto Rico Leads to Fears of Drug Shortages Nationwide
Two weeks after Hurricane Maria hit Puerto Rico, manufacturers are scrambling to get their plants back on line and avoid production problems. (Source: NYT Health)
Source: NYT Health - October 4, 2017 Category: Consumer Health News Authors: KATIE THOMAS and SHEILA KAPLAN Tags: Drugs (Pharmaceuticals) Medical Devices Hurricane Maria (2017) Factories and Manufacturing Methotrexate (Drug) Power Failures and Blackouts Labor and Jobs Food and Drug Administration Health and Human Services Department American Society Source Type: news

RA Outcomes with Tocilizumab Surpass Those of Adalimumab, Methotrexate (CME/CE)
(MedPage Today) -- Benefits reflected in both physical and mental scores (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - September 25, 2017 Category: Rheumatology Source Type: news

RA Patient Outcomes with Baricitinib Beat Methotrexate (CME/CE)
(MedPage Today) -- Benefits seen for physical function, fatigue, and quality of life (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - September 21, 2017 Category: Geriatrics Source Type: news

Drug Aimed at Inflammation May Lower Risk of Heart Disease and Cancer
A milestone finding for researchers, the connection of inflammatory responses to such illnesses could open the door to new treatments. (Source: NYT Health)
Source: NYT Health - August 27, 2017 Category: Consumer Health News Authors: DENISE GRADY Tags: Brigham and Women's Hospital Lancet, The (Journal) Heart Lung Cancer Smoking and Tobacco Cholesterol Research Preventive Medicine Stroke Immune System Statins (Cholesterol-Lowering Drugs) Clinical Trials Methotrexate (Drug) Ridke Source Type: news

Studies: Biologic Proves Worth as Monotherapy in RA (CME/CE)
(MedPage Today) -- A replacement for methotrexate in some patients? (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - August 14, 2017 Category: Geriatrics Source Type: news

Arthritis warning: THIS common medication could be linked to deadly liver failure
ARTHRITIS causes symptoms including painful joints and stiffness. One type, rheumatoid arthritis, is often treated with medications that reduce discomfort - but the side effects of the drug methotrexate, can include liver failure. (Source: Daily Express - Health)
Source: Daily Express - Health - August 10, 2017 Category: Consumer Health News Source Type: news

New research shows drug used for arthritis can treat blood cancer
A new study funded by the UK Medical Research Council (MRC) has revealed that the arthritis drug methotrexate (MTX) can be used to treat patients with a type of blood cancer, polycythemia vera (PV). (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - August 6, 2017 Category: Pharmaceuticals Source Type: news

MTX-induced Hypersensitivity Pneumonitis After 30 Years of Use MTX-induced Hypersensitivity Pneumonitis After 30 Years of Use
Methotrexate pneumonitis is not uncommon, but most frequently occurs within the first year of treatment. Could this patient's hypersensitivity pneumonitis be due to her 30 years on MTX?Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 31, 2017 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

Evaluation of toxicity after acute accidental methotrexate ingestions in children under 6 years old: a 16-year multi-center review - Hays H, Beuhler MC, Spiller HA, Weber J, Mowry JB, Ryan ML, Spiller NE, Webb A.
CONTEXT: There is little data on the frequency of adverse events following acute methotrexate ingestions in pediatric patients. Likewise, recommendations for observation length, site and management strategies in this population are not well established. Th... (Source: SafetyLit)
Source: SafetyLit - July 25, 2017 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Can Methotrexate Cause Growths on Your Wrist?
Title: Can Methotrexate Cause Growths on Your Wrist?Category: Doctor's& Expert's views on SymptomsCreated: 7/21/2017 12:00:00 AMLast Editorial Review: 7/21/2017 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - July 21, 2017 Category: Rheumatology Source Type: news

Nausea Common with Methotrexate in JIA (CME/CE)
(MedPage Today) -- Mitigating strategies include folate supplementation, anti-emetics (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - July 1, 2017 Category: Consumer Health News Source Type: news

Filgotinib Combined With MTX in Patients With Active RA Filgotinib Combined With MTX in Patients With Active RA
The addition of filgotinib may be an effective option for patients with active rheumatoid arthritis who did not sufficiently respond to methotrexate alone.Annals of the Rheumatic Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 21, 2017 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Fish as Medicine for Rheumatoid Arthritis
Eating fish may help reduce the joint pain and swelling of rheumatoid arthritis, a new study has found. (Source: NYT Health)
Source: NYT Health - June 21, 2017 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Fish and Other Marine Life Rheumatoid Arthritis Joints (Body Part) Methotrexate (Drug) Source Type: news

Tocilizumab Triumphs in Methotrexate Combo for RA Tocilizumab Triumphs in Methotrexate Combo for RA
It is not always clear which biologic to add to methotrexate for rheumatoid arthritis, but a new comparison between tocilizumab and a number of TNF inhibitors has some suggestions.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 20, 2017 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Rasuvo (Methotrexate Non-pyrogenic Solution for a Single Subcutaneous Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 31, 2017 Category: Drugs & Pharmacology Source Type: news

Moderate Alcohol Intake OK for RA Patients on Methotrexate
(MedPage Today) -- Patients on higher doses of meds may still need to abstain (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - May 30, 2017 Category: Primary Care Source Type: news

Triple Therapy More Cost-Effective Than MTX + Biologic in RA Triple Therapy More Cost-Effective Than MTX + Biologic in RA
Switching patients with MTX-resistant RA to triple-drug therapy (methotrexate, hydroxychloroquine, sulfasalazine) was recommended before changing to more expensive biologic therapy.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 30, 2017 Category: Consumer Health News Tags: Rheumatology News Source Type: news

In Rheumatoid Arthritis, Adding a Biologic Agent Before Trying Triple Therapy Likely Not Cost-Effective (FREE)
By Amy Orciari Herman Edited by David G. Fairchild, MD, MPH For patients with active rheumatoid arthritis despite methotrexate therapy, adding a biologic agent (e.g., etanercept) before trying triple therapy would lead to substantial cost increases without much … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - May 30, 2017 Category: Primary Care Source Type: news

Biologics before triple therapy not cost effective for rheumatoid arthritis
(American College of Physicians) Stepping up to biologic therapy when methotrexate monotherapy fails offers minimal incremental benefit over using a combination of drugs known as triple therapy, yet incurs large costs for treating rheumatoid arthritis (RA). Results of a comprehensive cost-effectiveness analysis suggest that patients who have RA and no contraindications to triple therapy should use it prior to a biologic as the next regimen. The study is published in Annals of Internal Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 29, 2017 Category: International Medicine & Public Health Source Type: news

FDA Approves Sarilumab for Adults With Rheumatoid Arthritis FDA Approves Sarilumab for Adults With Rheumatoid Arthritis
The drug will be marketed in self-injectible prefilled syringes and pens to be used once every 2 weeks. It offers an alternative to drugs such as methotrexate.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 23, 2017 Category: Consumer Health News Tags: Rheumatology News Alert Source Type: news

FDA Gives Nod to Sarilumab for Rheumatoid Arthritis
(MedPage Today) -- Can be used as monotherapy or with methotrexate for active RA (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - May 23, 2017 Category: American Health Source Type: news

Sanofi and Regeneron announce FDA Approval of Kevzara ® (sarilumab) for the treatment of moderately to severely active rheumatoid arthritis in adult patients
Sanofi and Regeneron Pharmaceuticals, Inc. have announced the U.S. Food and Drug Administration (FDA) approval of Kevzara® (sarilumab) for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to one or more disease modifying antirheumatic drugs (DMARDs), such as methotrexate (MTX). (Source: World Pharma News)
Source: World Pharma News - May 23, 2017 Category: Pharmaceuticals Tags: Featured Sanofi Business and Industry Source Type: news

Four-week Methotrexate Break Improves Flu Shot Response in RA Patients Four-week Methotrexate Break Improves Flu Shot Response in RA Patients
Temporarily withholding methotrexate (MTX) can improve the efficacy of seasonal influenza vaccination in patients with rheumatoid arthritis (RA), according to a new randomized clinical trial.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - May 18, 2017 Category: Allergy & Immunology Tags: Rheumatology News Source Type: news

Methotrexate Sodium Injection (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - May 18, 2017 Category: Drugs & Pharmacology Source Type: news

Adalimumab Effective in Children and Adolescents With Severe Psoriasis Adalimumab Effective in Children and Adolescents With Severe Psoriasis
Adalimumab offers benefits over methotrexate in children and adolescents with severe chronic plaque psoriasis, according to a phase 3 trial.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 15, 2017 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Mayo Clinic Q and A: Treatment often can keep morphea symptoms in check
DEAR MAYO CLINIC: About six months ago, a large, white dent appeared on my left buttock. After a biopsy, I was diagnosed with morphea. I was told that it is not systemic, but that the drug methotrexate could prevent future skin lesions and possibly cure the morphea. Is this possible, and what are the risks [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - May 6, 2017 Category: Databases & Libraries Source Type: news

Xatmep (Methotrexate Oral Solution) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 4, 2017 Category: Drugs & Pharmacology Source Type: news

Baricitinib for RA Bests Methotrexate at 1 Year (CME/CE)
(MedPage Today) -- Daily oral JAK inhibitor improves most disease measures (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - April 28, 2017 Category: Geriatrics Source Type: news

BSR: Baricitinib for RA Bests Methotrexate at 1 Year (CME/CE)
(MedPage Today) -- Daily oral JAK inhibitor improves most disease measures (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - April 28, 2017 Category: Geriatrics Source Type: news

BSR: Genetic Analysis IDs Methotrexate Responders (CME/CE)
(MedPage Today) -- Gene biomarkers differentiated between good responders and nonresponders (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - April 28, 2017 Category: Geriatrics Source Type: news

FDA Approves Xatmep (methotrexate) Oral Solution
Denver, April 26, 2017 — Silvergate Pharmaceuticals, Inc. leaders in the development and commercialization of innovative and safe medicines for children, today announced that the United States Food and Drug Administration (FDA) approved Xatmep... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - April 26, 2017 Category: Drugs & Pharmacology Source Type: news

FDA Approves XATMEP(TM), the First and Only Ready-To-Use Methotrexate Oral Solution
DENVER, April 26, 2017 -- (Healthcare Sales & Marketing Network) -- Silvergate Pharmaceuticals, Inc. (www.silvergatepharma.com), leaders in the development and commercialization of innovative and safe medicines for children, today announced that the Unite... Biopharmaceuticals, FDA Silvergate Pharmaceuticals, XATMEP, methotrexate, arthritis (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - April 26, 2017 Category: Pharmaceuticals Source Type: news

Methotrexate Sodium Injection (New - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - April 24, 2017 Category: Drugs & Pharmacology Source Type: news

Rheumatoid arthritis patients 'have experienced progress in recent decades'
This study confirms how important early diagnosis and the commencement of treatment is. It is also encouraging to hear about the progress that has been made over the last 20 years. "Now the scientific community must continue to build on this, so that together we can continue to harness the power of exceptional science and make everyday life better for all people with arthritis." (Source: Arthritis Research UK)
Source: Arthritis Research UK - April 18, 2017 Category: Rheumatology Source Type: news