AHA: Targeting Inflammation With Methotrexate Flops for CV Prevention
(MedPage Today) -- CIRT trial disappoints after CANTOS'win for the inflammatory hypothesis (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 10, 2018 Category: Cardiology Source Type: news

Low-Dose Methotrexate Does Not Reduce Risk of Cardiovascular Events
Inexpensive generic drug neither inhibited critical inflammatory pathways nor reduced rates of heart attack, stroke and cardiovascular death (Source: BWH News)
Source: BWH News - November 10, 2018 Category: Hospital Management Source Type: news

Medical News Today: Methotrexate and folic acid for rheumatoid arthritis
Doctors sometimes prescribe methotrexate for rheumatoid arthritis (RA), but it can lead to folic acid deficiencies. Learn more about managing this and other side effects. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 29, 2018 Category: Consumer Health News Tags: Rheumatoid Arthritis Source Type: news

First Head-to-Head Trial of a TNF Inhibitor Versus Methotrexate Monotherapy in Psoriatic Arthritis Shows ENBREL ® (Etanercept) Monotherapy and Combination Therapy Both Superior to Methotrexate
Results From Head-To-Head Phase 3 SEAM-PsA Study Assessing ENBREL and Methotrexate Regimens in Patients With Psoriatic Arthritis Presented at 2018 ACR/ARHP Annual Meeting Additional Phase 3b Results Show Modified ENBREL Formulation Associated With Significantly Lower Mean Injection Site Pain Versus Prior Formulation Data Presentations Result of Continued Dedication to Evaluate Optimal Use of ENBREL THOUSAND OAKS, Calif., Oct. 24, 2018 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that positive results from the Phase 3 SEAM-PsA study comparing the efficacy of Enbrel® (etanercept) monotherapy and ENBREL pl...
Source: Amgen News Release - October 24, 2018 Category: Pharmaceuticals Tags: Uncategorized Source Type: news

AbbVie rheumatoid arthritis drug succeeds in late stage trial
AbbVie Inc on Tuesday said its experimental rheumatoid arthritis (RA) treatment showed significant improvement in physical function, pain and quality of life compared with the commonly prescribed generic drug methotrexate in a late stage clinical trial. (Source: Reuters: Health)
Source: Reuters: Health - October 23, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

In Peripheral Spondyloarthritis, Early Biologic Needed In Peripheral Spondyloarthritis, Early Biologic Needed
New data from the CRESPA extension study show that the addition of methotrexate during biologic tapering has no significant effect on remission in peripheral spondyloarthritis.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 11, 2018 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Methotrexate Effective in Subcutaneous Psoriasis
(MedPage Today) -- Over 40% of patients achieved PASI 75 response in 16-week trial (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - September 15, 2018 Category: Dermatology Source Type: news

Subq Methotrexate Effective in Psoriasis
(MedPage Today) -- Over 40% of patients achieved PASI 75 response in 16-week trial (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - September 15, 2018 Category: Dermatology Source Type: news

Text Message: Take Your Methotrexate! (CME/CE)
(MedPage Today) -- Pilot program found better adherence in rheumatoid arthritis patients with weekly reminders (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - September 14, 2018 Category: Rheumatology Source Type: news

Double the Risk for Neurotoxicity for Hispanic Kids From ALL Rx Double the Risk for Neurotoxicity for Hispanic Kids From ALL Rx
Minority children, notably Hispanics, are more susceptible to developing methotrexate-induced neurotoxicity than non-Hispanic children during treatment for acute lymphoblastic leukemia (ALL).Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 12, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Subcutaneous Methotrexate in Moderate-to-Severe Psoriasis Subcutaneous Methotrexate in Moderate-to-Severe Psoriasis
A new study investigates the efficacy of an intensified two-step dosing schedule of subcutaneous methotrexate in patients with moderate-to-severe chronic plaque psoriasis.The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 3, 2018 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Younger Age, Active Disease Predictors of Methotrexate Failure in Patients With Inflammatory Polyarthritis
No abstract available (Source: Lippincott's Bone and Joint Newsletter)
Source: Lippincott's Bone and Joint Newsletter - August 15, 2018 Category: Orthopaedics Tags: Trends and Innovations Source Type: news

Consensus Guidelines for Methotrexate in JIA
(MedPage Today) -- Here are the 10 recommendations (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - August 4, 2018 Category: Pediatrics Source Type: news

Methotrexate and Azathioprine for Severe Atopic Dermatitis Methotrexate and Azathioprine for Severe Atopic Dermatitis
This study examined the long-term safety, efficacy, and tolerability of azathioprine and methotrexate in adults with moderate-to-severe atopic dermatitis.The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 2, 2018 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Supplementing leukemia therapy
Increasing the amount of dietary histidine enhances the sensitivity of leukemia xenografts in mice to methotrexate. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 31, 2018 Category: Science Authors: Foley, J. F. Tags: STKE Editors ' Choice Source Type: news

Methotrexate No Better Than Placebo for Steroid-Free Response, Remission in UC Methotrexate No Better Than Placebo for Steroid-Free Response, Remission in UC
Subcutaneous methotrexate (MTX) may not work better than placebo as maintenance therapy for ulcerative colitis (UC), researchers have found.Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 28, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Methotrexate in RA: Can Response Be Predicted?
(MedPage Today) -- Yes, using easily available clinical and psychological factors, say researchers (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - July 20, 2018 Category: Primary Care Source Type: news

Meds Improve Cardiovascular Risk in RA
(MedPage Today) -- Benefits seen for hydroxychloroquine, methotrexate, and tocilizumab (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - June 15, 2018 Category: Cardiology Source Type: news

CleanCision Wins Readers ’ Choice Award in MDEA Competition
There was much pomp and circumstance at the Medical Design Excellence Awards Tuesday as the best technologies were honored at the Jacob K. Javits Convention Center in New York. For one technology, however, it was a strong call of validation. CleanCision, earned the overall Reader’s Choice Award, which spans all categories in the competition. The active cleansing technology also earned the 2018 Medical Device Excellence Award Bronze Medal in the ER and OR Tools Category. CleanCision was developed by San Carlos, CA-based Prescient Medical. “We’re thrilled and we’re honored for validation of what we&rs...
Source: MDDI - June 13, 2018 Category: Medical Devices Authors: Omar Ford Tags: Design Source Type: news

Safe Stopping of Tocilizumab in RA: MTX Helps Safe Stopping of Tocilizumab in RA: MTX Helps
Patients with rheumatoid arthritis who achieve 6 months of remission or low disease activity by taking methotrexate plus tocilizumab can usually stop tocilizumab; restarting is effective if flares occur.Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 13, 2018 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Methotrexate Spares Steroids in Asthmatics
Title: Methotrexate Spares Steroids in AsthmaticsCategory: Doctor's& Expert's views on SymptomsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 6/13/2018 2:55:04 PM (Source: MedicineNet Asthma General)
Source: MedicineNet Asthma General - June 13, 2018 Category: Respiratory Medicine Source Type: news

Effect of Filgotinib With and Without Methotrexate in RA Effect of Filgotinib With and Without Methotrexate in RA
Filgotinib alone or as an addition to methotrexate may help rheumatoid arthritis patients realize improvements in patient-reported outcomes.Arthritis Research & Therapy (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 6, 2018 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

' Best Survival Data Ever' in Young T-Cell Leukemia Patients'Best Survival Data Ever' in Young T-Cell Leukemia Patients
Moving nelarabine to the front line and combining it with methotrexate improved 4-year disease-free survival in young patients with T-cell acute lymphoblastic leukemia.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 22, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

RA Therapy: After Methotrexate, Then What?
(MedPage Today) -- Strong preference for anti-TNF therapy despite emerging data (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - May 9, 2018 Category: Rheumatology Source Type: news

4 Trends Advancing Medtech
For the past 20 years, the Medical Design Excellence Awards have celebrated medical products that improve the quality and accessibility of healthcare. Our finalists this year carry on this tradition, while also keeping in step with today’s high-tech digital and consumer trends. With the help of our esteemed jurors, we have identified four key trends in this year’s group of finalists: risk reduction; faster, more-efficient healthcare delivery; the influence of the Internet of Things; and the consumerization of healthcare. We’ve been tracking a few of these trends in past awards programs, so they’re n...
Source: MDDI - April 27, 2018 Category: Medical Devices Authors: Daphne Allen Tags: MD & M East (New York) Design Source Type: news

Methotrexate Sodium Injection (Updated - Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - April 13, 2018 Category: Drugs & Pharmacology Source Type: news

Risk of Methotrexate Dosing Errors Prompts EMA Review Risk of Methotrexate Dosing Errors Prompts EMA Review
A recent routine assessment found that serious adverse events related to overdose, including fatalities, are still occurring, despite measures already in place to reduce dosing errors.News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 13, 2018 Category: Consumer Health News Tags: Rheumatology News Alert Source Type: news

Uveitis in JIA: Screen All, Treat Early (CME/CE)
(MedPage Today) -- Start with topical steroids, but methotrexate or biologics may be needed (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - April 4, 2018 Category: Pediatrics Source Type: news

Otrexup (Methotrexate Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 29, 2018 Category: Drugs & Pharmacology Source Type: news

2 Weeks Off Methotrexate OK for Flu Vaccine
(MedPage Today) -- Immunogenicity improved with no increase in RA disease activity (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - March 27, 2018 Category: Infectious Diseases Source Type: news

SetPoint Medical launches arthritis neurostim study
SetPoint Medical said today it launched the pilot trial of its neurostimulation device, looking to explore the system’s ability to to treat patients with drug refractory rheumatoid arthritis. The device is designed to be surgically placed on the vagus nerve to activate the body’s natural inflammatory reflex, the Valencia, Calif.-based company said. “Despite the effectiveness of biologic and targeted agents for the treatment of rheumatoid arthritis, many patients either do not respond, lose therapeutic response or are intolerant to these agents. There remains a real need to develop alternative therapeutic ...
Source: Mass Device - March 26, 2018 Category: Medical Devices Authors: Fink Densford Tags: Clinical Trials Neuromodulation/Neurostimulation SetPoint Medical Source Type: news

Xatmep (Methotrexate Oral Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 26, 2018 Category: Drugs & Pharmacology Source Type: news

JIA Flares Fewer with Longer Inactive Disease
(MedPage Today) -- Study can inform decision-making on stopping methotrexate (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - February 21, 2018 Category: Pediatrics Source Type: news

Etanercept Biosimilar Is Effective, Well-tolerated for Rheumatoid Arthritis Etanercept Biosimilar Is Effective, Well-tolerated for Rheumatoid Arthritis
The biosimilar LBEC0101 is equivalent to etanercept (Enbrel) in treating patients with rheumatoid arthritis (RA) who respond inadequately to methotrexate, according to researchers from Korea and Japan.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - February 20, 2018 Category: Orthopaedics Tags: Rheumatology News Source Type: news

Methotrexate May Help in Chronic Viral Arthritis (CME/CE)
(MedPage Today) -- Some benefits seen after chikungunya virus infection (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - January 26, 2018 Category: Infectious Diseases Source Type: news

Methotrexate Injection (New - Discontinuation)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - January 25, 2018 Category: Drugs & Pharmacology Source Type: news

6,000-year-old track record for healing leaky gut
When I was traveling in India, I had the privilege of studying Ayurvedic medicine with traditional Master Healers. Surrounded by lakes, oceans and mountains, Kerala, India, is the birthplace of Ayurveda medicine. My plane landed in Mumbai. From there, I made the 800-mile trip to Kerala down on the southwestern-most tip of the Indian peninsula. With origins dating back 6,000 years, Kerala is the birthplace of Ayurvedic medicine. I spent a lot of time at the AyurMana or “ancient healing house.” This is the oldest existing school of Ayurvedic medicine in the world. It was there that I observed how quickly...
Source: Al Sears, MD Natural Remedies - January 17, 2018 Category: Complementary Medicine Authors: Cathy Card Tags: Health Natural Cures anxiety arthritis Cancer celiac disease chronic fatigue depression diabetes digestive issues fibromyalgia leaky gut multiple sclerosis schizophrenia Source Type: news

High-Dose vs Low-Dose Methotrexate in Patients With RA High-Dose vs Low-Dose Methotrexate in Patients With RA
Could higher doses of methotrexate offer additional benefits to patients with early rheumatoid arthritis?Arthritis Research & Therapy (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 9, 2018 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Low-dose Methotrexate: Determinants for Adverse Events Low-dose Methotrexate: Determinants for Adverse Events
What are the relative risks of adverse events in patients exposed to low-dose methotrexate vs. placebo, and what factors might predispose patients to these events?The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 26, 2017 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

FDA OKs Tofacitinib (Xeljanz) for Active Psoriatic Arthritis FDA OKs Tofacitinib (Xeljanz) for Active Psoriatic Arthritis
The JAK inhibitor is indicated for patients who have failed to respond adequately or are intolerant to methotrexate or other disease-modifying antirheumatic drugs.FDA Approvals (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - December 18, 2017 Category: Allergy & Immunology Tags: Rheumatology News Alert Source Type: news

MTX Doubles Hepatotoxicity Risk in Psoriasis Patients
(MedPage Today) -- But methotrexate does not increase risk of liver disease in patients with rheumatoid arthritis (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - November 25, 2017 Category: Gastroenterology Source Type: news

Break From Methotrexate Boosts Flu Shot Efficacy in RA
With a drug holiday, patients with rheumatoid arthritis could improve their response to influenza vaccinations without increasing disease activity. (Source: CancerNetwork)
Source: CancerNetwork - November 14, 2017 Category: Cancer & Oncology Authors: Mariah Zebrowski Leach, JD, MS Tags: Rheumatoid Arthritis Source Type: news

Break From Methotrexate Boosts Flu Shot Efficacy in RA
With a drug holiday, patients with rheumatoid arthritis could improve their response to influenza vaccinations without increasing disease activity. (Source: ConsultantLive)
Source: ConsultantLive - November 14, 2017 Category: Internal Medicine Authors: Mariah Zebrowski Leach, JD, MS Tags: Rheumatoid Arthritis Source Type: news

Baricitinib Eases Rheumatoid Arthritis Pain Baricitinib Eases Rheumatoid Arthritis Pain
The JAK inhibitor reduced pain in rheumatoid arthritis patients refractory to methotrexate more than a TNF inhibitor, a new analysis of RA-BEAM data shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 8, 2017 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Stop Methotrexate in RA Patients for 2 Weeks After Flu Shot Stop Methotrexate in RA Patients for 2 Weeks After Flu Shot
A temporary suspension of methotrexate boosts the immune response to flu vaccination with no increase in rheumatoid arthritis (RA) disease activity, a randomized clinical trial shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 5, 2017 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Methotrexate Sodium Injection (New - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - October 12, 2017 Category: Drugs & Pharmacology Source Type: news

Hurricane Damage in Puerto Rico Leads to Fears of Drug Shortages Nationwide
Two weeks after Hurricane Maria hit Puerto Rico, manufacturers are scrambling to get their plants back on line and avoid production problems. (Source: NYT Health)
Source: NYT Health - October 4, 2017 Category: Consumer Health News Authors: KATIE THOMAS and SHEILA KAPLAN Tags: Drugs (Pharmaceuticals) Medical Devices Hurricane Maria (2017) Factories and Manufacturing Methotrexate (Drug) Power Failures and Blackouts Labor and Jobs Food and Drug Administration Health and Human Services Department American Society Source Type: news

RA Outcomes with Tocilizumab Surpass Those of Adalimumab, Methotrexate (CME/CE)
(MedPage Today) -- Benefits reflected in both physical and mental scores (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - September 25, 2017 Category: Rheumatology Source Type: news

RA Patient Outcomes with Baricitinib Beat Methotrexate (CME/CE)
(MedPage Today) -- Benefits seen for physical function, fatigue, and quality of life (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - September 21, 2017 Category: Geriatrics Source Type: news

Drug Aimed at Inflammation May Lower Risk of Heart Disease and Cancer
A milestone finding for researchers, the connection of inflammatory responses to such illnesses could open the door to new treatments. (Source: NYT Health)
Source: NYT Health - August 27, 2017 Category: Consumer Health News Authors: DENISE GRADY Tags: Brigham and Women's Hospital Lancet, The (Journal) Heart Lung Cancer Smoking and Tobacco Cholesterol Research Preventive Medicine Stroke Immune System Statins (Cholesterol-Lowering Drugs) Clinical Trials Methotrexate (Drug) Ridke Source Type: news