Janssen to Highlight Depth of Solid Tumor Portfolio at ASCO GU
RARITAN, N.J., February 3, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today multiple data presentations from a robust solid tumor portfolio that will be featured at the American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium, taking place February 13-15 in San Francisco. Company-sponsored data presentations will include clinical results for ERLEADA® (apalutamide) and niraparib in prostate cancer; and BALVERSA™ (erdafitinib) in bladder cancer. “We are committed to improving outcomes in patients with prostate and bladder cancer where high unmet...
Source: Johnson and Johnson - February 3, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Asthma and Treatment With Inhaled Corticosteroids Asthma and Treatment With Inhaled Corticosteroids
Are asthma patients who use inhaled corticosteroids at an increased risk for pneumonia and hospitalization?BMC Pulmonary Medicine (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - January 28, 2020 Category: Allergy & Immunology Tags: Pulmonary Medicine Journal Article Source Type: news

Drug Trials Snapshots: XPOVIO
XPOVIO is a drug used to treat a form of blood cancer called multiple myeloma. It is to be used in combination with dexamethasone (a type of corticosteroid) in patients with no other treatment options whose cancer came back after, or did not respond to, at least four previous treatments. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - January 27, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Potent, Unregulated Steroid Creams Readily Available in U.S.
FRIDAY, Jan. 24, 2020 -- Potent prescription-strength topical corticosteroids without a prescription (PSTCw/oP) are readily available in many U.S. cities, according to a letter to the editor published in the February issue of the Journal of the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 24, 2020 Category: Pharmaceuticals Source Type: news

Sport-related concussion preceding adrenal insufficiency and hypopituitarism - Northam WT, Alexander A, Carneiro K.
A 49-year-old female with history of daily inhaled corticosteroid use for asthma presented to a concussion clinic 7 wk after sport-related head injury with headache, visual blurring, dizziness, nausea, fatigue, polydipsia, and polyuria. Examination reveale... (Source: SafetyLit)
Source: SafetyLit - January 13, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Phase III GRAVITAS-301 Study Fails to Meet Primary Endpoint of Improved Overall Response
The study evaluating itacitinib in combination with corticosteroids in patients with treatment-na ïve acute graft-versus-host disease did not produce statistically significant results. (Source: CancerNetwork)
Source: CancerNetwork - January 6, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Topical Calcineurin Inhibitors for Oral Lichen Planus Topical Calcineurin Inhibitors for Oral Lichen Planus
Topical corticosteroids are standard therapy for oral lichen planus. Might topical calcineurin inhibitors be feasible as alternatives in patients for whom corticosteroids aren't effective?The British Journal of Dermatology (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - January 3, 2020 Category: Allergy & Immunology Tags: Dental & Oral Health Journal Article Source Type: news

Adverse Events Related to Low Dose Corticosteroids in AIH Adverse Events Related to Low Dose Corticosteroids in AIH
Does the use of low doses of corticosteroids ameliorate potential adverse events associated with the long-term use of these drugs in patients with autoimmune hepatitis?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 1, 2020 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Sinuses bothering you? Use those nasal sprays regularly
(University of Cincinnati) Many chronic rhinosinusitis patients worry about overuse of antibiotics. A University of Cincinnati researcher says appropriate use of nasal saline and corticosteroid sprays can curtail their fears. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 17, 2019 Category: International Medicine & Public Health Source Type: news

FDA accepts supplemental biologics license application for Xolair (omalizumab) for the treatment of nasal polyps
Roche announced today that the U.S. Food and Drug Administration (FDA) has accepted the company ’s supplemental Biologics License Application (sBLA) for Xolair® (omalizumab) for the treatment of nasal polyps in adult patients 18 years of age and older with inadequate response to intranasal corticosteroids. (Source: Roche Investor Update)
Source: Roche Investor Update - December 11, 2019 Category: Pharmaceuticals Source Type: news

Featured Review: Interventions to reduce Staphylococcus aureus in the management of eczema
In this interview with review author Anjna Rani we learn more about the recently published review,Interventions to reduce Staphylococcus aureus in the management of eczema.Tell us about this Cochrane Review  This review looks at the evidence of treatments, such as antibiotics, antibacterial soaps/baths, to reduce a type of bacteria called Staphylococcus aureus (S. aureus) that is predominant on skin with eczema.   The review assessed a wide variety of treatments to help treat/reduce infected eczema – 41 studies involving 1753 participants were included in total.Why is it important for patients with eczema?E...
Source: Cochrane News and Events - December 10, 2019 Category: Information Technology Authors: Katie Abbotts Source Type: news

Featured review: Corticosteroids for treating sepsis
The authors reviewed the evidence on the effect on death of using corticosteroids in children and adults with sepsis.Sepsis is present when an infection is complicated by organ failure. People develop rapid breathing, hypotension (low blood pressure), and mental confusion. Sepsis can interfere with the effectiveness of the body ’s corticosteroids, which serve as a key defence against infection. Corticosteroids have been given for decades to people with infection resulting from various causes.The review included 61 trials (12,192 participants). Fifty-eight trials compared corticosteroids to no corticosteroids  (p...
Source: Cochrane News and Events - December 9, 2019 Category: Information Technology Authors: Katie Abbotts Source Type: news

Development of Locally Applied Corticosteroid Products for the Short-Term Treatment of Symptoms Associated with Internal or External Hemorrhoids Guidance for Industry
CDER Guidance: Clinical/Medical (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - December 6, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Risk for Side Effects With Repeat Oral Corticosteroids Risk for Side Effects With Repeat Oral Corticosteroids
Systemic corticosteroids can lead to adverse events, new research shows, but in many cases, education about preventive therapy can reduce prescriptions.Medscape Medical News (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - November 27, 2019 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news

Roche ’s Gazyva (obinutuzumab), in combination with standard of care, more than doubles the percentage of lupus nephritis patients achieving complete renal response, compared to standard of care alone
Roche today announced data from the phase II NOBILITY study, investigating the safety and efficacy of Gazyva ® (obinutuzumab) for adults with proliferative lupus nephritis.1 The study met the primary endpoint with Gazyva, in combination with standard of care (mycophenolate mofetil or mycophenolic acid and corticosteroids), demonstrating superiority compared to placebo plus standard of care. (Source: Roche Media News)
Source: Roche Media News - November 11, 2019 Category: Pharmaceuticals Source Type: news

Roche ’s Gazyva (obinutuzumab), in combination with standard of care, more than doubles the percentage of lupus nephritis patients achieving complete renal response, compared to standard of care alone
Roche today announced data from the phase II NOBILITY study, investigating the safety and efficacy of Gazyva ® (obinutuzumab) for adults with proliferative lupus nephritis.1 The study met the primary endpoint with Gazyva, in combination with standard of care (mycophenolate mofetil or mycophenolic acid and corticosteroids), demonstrating superiority compared to placebo plus standard of care. (Source: Roche Investor Update)
Source: Roche Investor Update - November 11, 2019 Category: Pharmaceuticals Source Type: news

Mayo Clinic Minute: Benefits and risks of corticosteroid shots
Corticosteroid injections are used to relieve pain in joints due to arthritis and overuse injuries. A recent study suggests that frequent steroid use may affect cartilage health. Dr. Raul Rosario-Concepcion, a Mayo Clinic sports medicine specialist, explains the benefits and risks of these injections. Watch: The Mayo Clinic Minute https://youtu.be/tYwUHex9HSc Journalists: Broadcast-quality video pkg (0:59) is [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - November 6, 2019 Category: Databases & Libraries Source Type: news

Reslizumab Appears Helpful in Refractory Asthma Reslizumab Appears Helpful in Refractory Asthma
Intravenous reslizumab (Cinquair, Teva) appears beneficial in patients with inadequately controlled oral-corticosteroid-dependent asthma, according to post-hoc analyses.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - October 31, 2019 Category: Allergy & Immunology Tags: Pulmonary Medicine News Source Type: news

Portland startup wins pitch fest for next-generation corticosteroid technology
Sparrow Pharmaceuticals' founder David Katz believes his therapy will have fewer side effects but prove equally as effective in treating autoimmune disease. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - October 30, 2019 Category: Pharmaceuticals Authors: Elizabeth Hayes Source Type: news

Long-term use of corticosteroids can cause Cushing's syndrome
An Italian study, published inExperimental and Therapeutic Medicine, reports that long-term use of steroids for skin problems can increase the risk of developing Cushing's syndrome, with serious damage to bone health.Cushing's Disease News (Source: Society for Endocrinology)
Source: Society for Endocrinology - October 30, 2019 Category: Endocrinology Source Type: news

Alembic Pharma gets USFDA nod for Desonide Ointment
Desonide Ointment, 0.05 per cent, is a low potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - October 24, 2019 Category: Pharmaceuticals Source Type: news

Corticosteroid Injections for Osteoarthritis: More Harm Than Good?
Title: Corticosteroid Injections for Osteoarthritis: More Harm Than Good?Category: Health NewsCreated: 10/22/2019 12:00:00 AMLast Editorial Review: 10/23/2019 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - October 23, 2019 Category: Rheumatology Source Type: news

Do steroid injections into joints do more harm than good?
X-ray imaging shows that corticosteroid injections for osteoarthritis pain...Read more on AuntMinnie.comRelated Reading: 3D MRI helps predict osteoarthritis risk after ACL tears 3 ways to reduce unnecessary MRI knee scans 6 ways AI will enhance musculoskeletal imaging Many knee MRI scans may not be clinically indicated New 3D CT technique tops x-ray for diagnosing arthritis (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - October 15, 2019 Category: Radiology Source Type: news

Steroid Shots for Painful Joints May Make Matters Worse
TUESDAY, Oct. 15, 2019 -- Corticosteroid shots are often used to ease arthritis pain, but a new study suggests they may be riskier than thought. Researchers found that among patients who had the treatment at their center, 8% had complications. Most... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 15, 2019 Category: General Medicine Source Type: news

Corticosteroid Injections for Symptomatic Knee OA Corticosteroid Injections for Symptomatic Knee OA
Intra-articular corticosteroid injections are commonly used for the symptomatic relief of knee osteoarthritis. When should they be used and what are the potential complications?Journal of the American Academy of Orthopaedic Surgeons (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 26, 2019 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Featured Review: How safe is it to add regular formoterol to inhaled corticosteroid for adults or children with asthma?
Asthma is a disease of the lungs, symptoms include wheezing, breathlessness, and chest tightness.Two main features of asthma are underlying inflammation and bronchoconstriction (tightening of the muscles around small tubes in the lungs). The inflammation can be treated with daily steroid inhalers. The bronchoconstriction can be treated with a beta2-agonist to relax the muscles. This opens up the airways and makes it easier to breathe. Beta2-agonists can be used two ways: to provide relief from symptoms of chest tightness ('short-acting beta2-agonists') and to help prevent symptoms from occurring ('long-acting beta2-agonist...
Source: Cochrane News and Events - September 26, 2019 Category: Information Technology Authors: Katie Abbotts Source Type: news

Vedolizumab Beats Adalimumab for Ulcerative Colitis Remissions
WEDNESDAY, Sept. 25, 2019 -- In moderate-to-severe ulcerative colitis, vedolizumab is superior to adalimumab for achieving clinical remission and endoscopic improvement, but not corticosteroid-free clinical remission, and ustekinumab is superior to... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 25, 2019 Category: Pharmaceuticals Source Type: news

Corticosteroids Impair Granulocyte Transfusion Therapy By Targeting NET Formation and Neutrophil Antifungal Functions Via ROS/Dectin1 Pathways
Conference abstracts (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - September 22, 2019 Category: Respiratory Medicine Authors: MeganB Source Type: news

Retinopathy Associated With Topical Oral Corticosteroid Use Retinopathy Associated With Topical Oral Corticosteroid Use
Central serous retinopathy has been reported following systemic corticosteroid use. Might a topical corticosteroid used for dental treatment be the cause of this patient's central serous retinopathy?Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 18, 2019 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

Prostate drugs may increase your risk of developing Type 2 diabetes, warn scientists
(Natural News) Almost every major class of prescription drug raises your risk of developing Type-2 diabetes. Taking statins, antihypertensives, immunosuppressants, antipsychotics, antiretrovirals, and/or corticosteroids increases your risk of developing type 2 diabetes mellitus. Now researchers find that prostate drugs also play a role in the development of Type-2 diabetes. Their research was published in the... (Source: NaturalNews.com)
Source: NaturalNews.com - September 10, 2019 Category: Consumer Health News Source Type: news

Adjunctive Corticosteroid Treatment in Septic Shock Adjunctive Corticosteroid Treatment in Septic Shock
This article reviews the continuing uncertainty and the current state of the evidence regarding the utility of corticosteroids in treatment of septic shock. What are the implications for practice?Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 29, 2019 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

As - Needed Inhaler Use an Option for Children With Mild Asthma
Study in African - American children shows symptom - based adjustment of inhaled corticosteroids is feasible (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - August 23, 2019 Category: Respiratory Medicine Tags: Family Medicine, Pediatrics, Pharmacy, Pulmonology, Allergy, Emergency Medicine, Journal, Source Type: news

Eczema treatment: Avoiding this food could help reduce the inflammation
ECZEMA treatments usually come in the form of emollients and topical corticosteroid creams - but these don ’t always work for everyone. Diet could be a trigger for people’s skin irritation, and it may be wise to cut down on a certain food. (Source: Daily Express - Health)
Source: Daily Express - Health - August 23, 2019 Category: Consumer Health News Source Type: news

Getting the Right Care for Painful Autoimmune Conditions
A corticosteroid can quickly relieve symptoms of both polymyalgia rheumatica and temporal arteritis. But a delay could cause vision loss, a stroke or even death. (Source: NYT Health)
Source: NYT Health - August 19, 2019 Category: Consumer Health News Authors: Jane E. Brody Tags: Stroke Steroids Autoimmune Diseases Immune System Source Type: news

GPs should avoid antibiotics for non-bullous impetigo
NICE proposes use of antiseptic creams instead Related items fromOnMedica Single-dose malaria drug eliminates parasite from liver Patients often avoid vaccinations due to fear of side effects Double check patients with ‘penicillin’ allergy to avoid MRSA risk Ibuprofen not a safe alternative to antibiotics for uncomplicated UTIs Inhaled corticosteroids linked to higher infection risk (Source: OnMedica Latest News)
Source: OnMedica Latest News - August 15, 2019 Category: UK Health Source Type: news

Inappropriate corticosteroid use in COPD not beneficial and costly
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - August 1, 2019 Category: Drugs & Pharmacology Source Type: news

The Caveat to Inhaled Corticosteroids for Asthma The Caveat to Inhaled Corticosteroids for Asthma
Treating asthma is straightforward--or is it? Dr Holley presents a caveat to the'early and often'treatment approach.Medscape Critical Care (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - July 26, 2019 Category: Intensive Care Tags: Pulmonary Medicine Viewpoint Source Type: news

Moffitt research of Selinexor for multiple myeloma facilitates FDA approval
(H. Lee Moffitt Cancer Center& Research Institute) A first-in-class drug recently granted accelerated approval by the US Food and Drug Administration (FDA) for adult patients with heavily pretreated multiple myeloma has been the subject of study at Moffitt Cancer Center for years. Now, selinexor (XPOVIO ™ , Karyopharm Therapeutics) used in combination with the corticosteroid dexamethasone will offer another option for patients with multiple myeloma who have exhausted the most common therapies for the disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 24, 2019 Category: Cancer & Oncology Source Type: news

Unclear Which Inhaled Steroids Least Affect Growth in Asthmatic Children Unclear Which Inhaled Steroids Least Affect Growth in Asthmatic Children
It's not clear which inhaled corticosteroids and delivery devices have the least adverse impact on growth in children with persistent asthma, a systematic review concludes.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - July 18, 2019 Category: Allergy & Immunology Tags: Pulmonary Medicine News Source Type: news

Drug Trials Snapshots: XPOVIO
XPOVIO is a drug used to treat a form of blood cancer called multiple myeloma. It is to be used in combination with dexamethasone (a type of corticosteroid) in patients with no other treatment options whose cancer came back after, or did not respond to, at least four previous treatments. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 17, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Medical News Today: What to know about scar tissue
A person may develop scar tissue after receiving a wound or undergoing surgery. Scars can present in a variety of ways, and there are several ways to treat them, including using corticosteroids. However, not all treatments will work for everyone. Learn more about scar tissue here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 16, 2019 Category: Consumer Health News Tags: Dermatology Source Type: news

FDA approves new treatment for refractory multiple myeloma
FDA grants accelerated approval to Xpovio (selinexor) tablets in combination with the corticosteroid dexamethasone for the treatment of adult patients with relapsed refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is resistant to several other form (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 4, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

FDA Approves Selinexor for Refractory Multiple Myeloma FDA Approves Selinexor for Refractory Multiple Myeloma
Selinexor is approved in combination with the corticosteroid dexamethasone for the treatment of relapsed/refractory multiple myeloma in patients who are out of treatment options.FDA Approvals (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - July 3, 2019 Category: Cancer & Oncology Tags: Hematology-Oncology News Alert Source Type: news

FDA approves new treatment for refractory multiple myeloma
Today, the U.S. Food and Drug Administration granted accelerated approval to Xpovio (selinexor) tablets in combination with the corticosteroid dexamethasone for the treatment of adult patients with relapsed refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is resistant to several other forms of treatment, (Source: World Pharma News)
Source: World Pharma News - July 3, 2019 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

FDA Approves Selinexor Combination for Refractory Multiple Myeloma
The FDA approved selinexor in combination with the corticosteroid dexamethasone for the treatment of adult patients with relapsed/refractory multiple myeloma. (Source: CancerNetwork)
Source: CancerNetwork - July 3, 2019 Category: Cancer & Oncology Authors: Erin Kayata Source Type: news

Medical News Today: Breathing treatments: Everything you need to know
Many different types of breathing treatment are available, including bronchodilators, corticosteroids, and antimicrobial drugs. Learn more about these and other treatments here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 29, 2019 Category: Consumer Health News Tags: Respiratory Source Type: news

What Infectious Diseases are Important to Consider in Transplantation Patients?
Discussion Transplantation is not a common problem for primary care physicians but when a child’s disease has progressed to end-stage organ failure, transplantation can be the only treatment available. While the primary care provider usually is not involved in the daily management of patients before, during and after transplantation, they can be involved in many areas. These can include providing appropriate primary and acute care, ordering and obtaining necessary medical tests, medications and equipment, assisting with medical insurance, providing medical history and records to consultants, translating medical infor...
Source: PediatricEducation.org - June 24, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Transcriptional activation of elephant shark mineralocorticoid receptor by corticosteroids, progesterone, and spironolactone
The mineralocorticoid receptor (MR) is a nuclear receptor and part of a large and diverse family of transcription factors that also includes receptors for glucocorticoids, progesterone, androgens, and estrogens. The corticosteroid aldosterone is the physiological activator of the MR in humans and other terrestrial vertebrates; however, its activator is not known in cartilaginous fish, the oldest group of extant jawed vertebrates. Here, we analyzed the ability of corticosteroids and progesterone to activate the full-length MR from the elephant shark (Callorhinchus milii). On the basis of their measured activities, aldostero...
Source: Signal Transduction Knowledge Environment - June 4, 2019 Category: Science Authors: Katsu, Y., Kohno, S., Oka, K., Lin, X., Otake, S., Pillai, N. E., Takagi, W., Hyodo, S., Venkatesh, B., Baker, M. E. Tags: STKE Research Articles Source Type: news

Medical News Today: What to know about betamethasone
Betamethasone is an inflammation-reducing corticosteroid that helps treat a range of skin conditions. Learn about the types, uses, and side effects of this medication here, as well as the warnings regarding its use. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 3, 2019 Category: Consumer Health News Tags: Dermatology Source Type: news

Xolair (omalizumab) significantly reduced nasal polyps and congestion symptoms in adults with chronic rhinosinusitis with nasal polyps in two phase III studies
Roche today announced positive topline data from two Phase III multicenter studies evaluating Xolair ® (omalizumab) for the treatment of adults with chronic rhinosinusitis with nasal polyps (CRSwNP) who have not adequately responded to intranasal corticosteroids. (Source: Roche Investor Update)
Source: Roche Investor Update - June 3, 2019 Category: Pharmaceuticals Source Type: news