Janssen Provides Update on Phase 3 ACIS Study in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with ERLEADA ® (apalutamide) and ZYTIGA® (abiraterone acetate) Plus Prednisone Combination
RARITAN, N.J., April 19, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that regulatory submissions based on the Phase 3 ACIS study, which evaluated the combination of ERLEADA® (apalutamide) and ZYTIGA® (abiraterone acetate) plus prednisone in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC), will not be pursued. As presented at the American Society of Clinical Oncology’s Genitourinary (ASCO GU) Cancers Symposium in February 2021, the ACIS study met its primary endpoint of radiographic progression-free survival (rPFS); ho...
Source: Johnson and Johnson - April 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Intranasal Third-Generation CGRP Effective for Acute Migraine Intranasal Third-Generation CGRP Effective for Acute Migraine
Intranasal zavegepant, a third-generation calcitonin gene-related peptide receptor agonist, is effective and well tolerated in the treatment of acute migraine, new research shows.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - April 19, 2021 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

AstraZeneca side effects: Three symptoms that may accompany a headache - when to get help
ASTRAZENECA side effects can cause headaches which health experts state is perfectly normal. However, a headache accompanied with either blurred vision, nausea or vomiting could be a medical emergency. Why? (Source: Daily Express - Health)
Source: Daily Express - Health - April 19, 2021 Category: Consumer Health News Source Type: news

Cochrane PaPaS seeks full-time Systematic Reviewer - remote
Closing date: 28 April 2021Location: remote (home-working)The Cochrane Pain, Palliative and Supportive Care (Cochrane PaPaS) Review Group is looking for an experienced Systematic Reviewer to undertake high quality, priority Cochrane systematic reviews for publication in the Cochrane Library.The focus of PaPaS is studies of interventions for acute pain, chronic pain, headache and migraine, palliative care for those with life-limiting disease or illness, and supportive care of patients and significant others living with serious illness.The candidate will work with a multidisciplinary team to undertake new priority reviews, o...
Source: Cochrane News and Events - April 19, 2021 Category: Information Technology Authors: Lydia Parsonson Source Type: news

Prevalence of Migraine, Severe Headache Up for Adults With IBD
MONDAY, April 19, 2021 -- Adults with inflammatory bowel disease (IBD) have a higher prevalence of migraine or severe headache, according to a study published online March 23 in Headache: The Journal of Head and Face Pain. Yong Liu, M.D., from the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 19, 2021 Category: Pharmaceuticals Source Type: news

Migraine Treatment and COVID-19 Vaccines: No Cause for Concern Migraine Treatment and COVID-19 Vaccines: No Cause for Concern
Does migraine treatment impair the efficacy, or impact the safety, of the COVID-19 vaccine and conversely, might the COVID-19 vaccine adversely impact the efficacy of migraine treatments?Headache (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 19, 2021 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Naspers Has a $100 Billion Headache
Africa’s largest-listed company is struggling with a remarkably successful investment it made years ago in Tencent—that is, how to... (Source: Reuters: Health)
Source: Reuters: Health - April 18, 2021 Category: Consumer Health News Source Type: news

Bangkok nightlife clusters expose Thailand's virus stumbles
When Thailand’s transport minister was diagnosed with COVID-19, it was Prime Minister Prayuth Chan-ocha who got a headache (Source: ABC News: Health)
Source: ABC News: Health - April 15, 2021 Category: Consumer Health News Tags: Health Source Type: news

Johnson & Johnson Statement on CDC Advisory Committee Meeting on Company COVID-19 Vaccine
NEW BRUNSWICK, N.J., April 14, 2021 – The U.S. Centers for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP) convened today to consider reports of an extremely rare disorder involving blood clots in combination with low platelets observed in a small number of individuals following vaccination with the Johnson & Johnson COVID-19 vaccine. “The safety and well-being of the people who use our products is our number one priority, and we strongly support awareness of the signs and symptoms of this extremely rare event to ensure the correct diagnosis, appropriate treatment an...
Source: Johnson and Johnson - April 15, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Johnson & Johnson Statement on COVID-19 Vaccine
NEW BRUNSWICK, N.J., April 13, 2021– The safety and well-being of the people who use our products is our number one priority. We are aware of an extremely rare disorder involving people with blood clots in combination with low platelets in a small number of individuals who have received our COVID-19 vaccine. The United States Centers for Disease Control (CDC) and Food and Drug Administration (FDA) are reviewing data involving six reported U.S. cases out of more than 6.8 million doses administered. Out of an abundance of caution, the CDC and FDA have recommended a pause in the use of our vaccine. In addition, we have ...
Source: Johnson and Johnson - April 13, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Johnson & Johnson Statement on COVID-19 Vaccine (Updated)
NEW BRUNSWICK, N.J., April 13, 2021– The safety and well-being of the people who use our products is our number one priority. We are aware of an extremely rare disorder involving people with blood clots in combination with low platelets in a small number of individuals who have received our COVID-19 vaccine. The United States Centers for Disease Control (CDC) and Food and Drug Administration (FDA) are reviewing data involving six reported U.S. cases out of more than 6.8 million doses administered. Out of an abundance of caution, the CDC and FDA have recommended a pause in the use of our vaccine. In addition, we have ...
Source: Johnson and Johnson - April 13, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Experts' medicine cabinet essentials: The shopping list to keep your family healthy
Whatever health problem you face -from cuts and stings to a thumping headache or even mild symptoms of Covid, such as fever - it is vital to have the correct, up-to-date products to hand. (Source: the Mail online | Health)
Source: the Mail online | Health - April 12, 2021 Category: Consumer Health News Source Type: news

Headache During Covid-19: Implications for the ICHD Headache During Covid-19: Implications for the ICHD
What has the COVID-19 pandemic taught us about headache, and how might this help refine our definition of"headache attributed to systemic viral infection" in the ICHD?Headache (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 12, 2021 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Two New Studies Point to How AstraZeneca ’s COVID-19 Vaccine Is Linked to Blood Clots
In two papers published in the New England Journal of Medicine (NEJM), researchers in Europe provide the most detailed explanation yet for what is behind the clotting side effects reported among people getting vaccinated with the AstraZeneca COVID-19 shot. In both papers, researchers found that people getting the vaccine had higher levels of antibodies directed against a cluster of immune-related cells that the body might form in response to the vaccine. These clusters include platelets, which help blood to clot when you get cut or injured, and the antibodies stick to the platelet-complex and form dangerous clots that can ...
Source: TIME: Health - April 9, 2021 Category: Consumer Health News Tags: Uncategorized COVID-19 Source Type: news

Green Light May Put a Stop to Migraine
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - April 9, 2021 Category: General Medicine Source Type: news

Green Light May Put a Stop to Migraine Green Light May Put a Stop to Migraine
In the first clinical study to evaluate green light exposure as a potential preventive therapy for migraine, patients experienced about a 60% reduction in pain intensity.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - April 8, 2021 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

The litigation complexity of posttraumatic headaches - Hubbard JE, Hodge SDJ.
PURPOSE OF REVIEW: This review explores the workings of the legal process in posttraumatic headache (PTH) claims by discussing representative court cases, the approaches taken by both plaintiff and defense attorneys in evaluating a client with PTH, and the... (Source: SafetyLit)
Source: SafetyLit - April 8, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

The stressors of stress on your body and behavior
This article is written by Mayo Clinic Staff.  Common effects of stress Indeed, stress symptoms can [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 8, 2021 Category: Databases & Libraries Source Type: news

New Real-World Observational Analysis of UPTRAVI ® (selexipag) Underscores the Importance of Risk Assessment for Treating Pulmonary Arterial Hypertension (PAH) Patients
SOUTH SAN FRANCISCO, CA – April 6, 2021 – Findings from an analysis of the first 500 patients enrolled in the SPHERE registry (SelexiPag: tHe usErs dRug rEgistry) found more than three-quarters (76%) of pulmonary arterial hypertension (PAH) patients treated with UPTRAVI® (selexipag) either maintained (56%) or reduced (20%) their one-year mortality risk score. The SPHERE results were published in the April issue of the Journal of Heart and Lung Transplantation (JHLT). SPHERE is an ongoing real-world, observational, user registry using two different risk assessment methods that describes the clinical characte...
Source: Johnson and Johnson - April 6, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

NHS rolls out headache-busting gadget
NHS England is expanding the use of gammaCore after successful trials held over the last two years. (Source: NHS Networks)
Source: NHS Networks - April 6, 2021 Category: UK Health Source Type: news

Erenumab in the Prevention of Episodic and Chronic Migraine Erenumab in the Prevention of Episodic and Chronic Migraine
This study assessed the effectiveness, safety, and tolerability of erenumab, a CGRPR antagonist, in a real-life migraine population.Headache (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 5, 2021 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Taking paracetamol can make chronic pain worse - Dr Philippa issues warning
MOST people reach for a paracetamol when they are experiencing chronic pain but This Morning's Dr Philippa suggests this should not be your first port of call. Taking paracetamol can cause "paracetamol overuse headache," she warned. (Source: Daily Express - Health)
Source: Daily Express - Health - April 5, 2021 Category: Consumer Health News Source Type: news

What Are Recommendations for Using Portable Listening Devices?
In this study listening to audiobooks, movies, or playing videogames was less likely to exceed the threshold. However the use of PLDs has increased overtime, particularly with the need for online educational activities due the COVID-19 pandemic. Use of PLDs particularly in the setting of other ambient noise and the duration of the activities may have changed since this and other studies were published. Problems associated with increased noise aren’t just hearing loss but other aural problems including tinnitus, sound distortion, difficulty understanding speech, dizziness, and earache. Other “extra-auditive da...
Source: PediatricEducation.org - April 5, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Management of pediatric post-concussion headaches: national survey of abortive therapies used in the emergency department - Lambrinakos-Raymond K, Dubrovsky AS, Gagnon I, Zemek R, Burstein B.
Children frequently present to an Emergency Department (ED) following concussion and headache is the most commonly associated symptom. Recent guidelines emphasize the importance of analgesia for post-concussion headache (PCH), yet evidence to inform treatm... (Source: SafetyLit)
Source: SafetyLit - April 4, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

These two groups tend to report more COVID vaccine side effects. This is why
Headache, chills, fever — these are just a few of the side-effects some have reported after getting the Moderna or Pfizer COVID-19 vaccines. (Source: Reuters: Health)
Source: Reuters: Health - April 3, 2021 Category: Consumer Health News Source Type: news

Johnson & Johnson Expands Phase 2a Clinical Trial of COVID-19 Vaccine Candidate to Include Adolescents
New Brunswick, NJ (April 2, 2021) – Johnson & Johnson (the Company) has begun vaccinating adolescent participants in the ongoing Phase 2a clinical trial for its COVID-19 vaccine candidate, developed by the Janssen Pharmaceutical Companies of Johnson & Johnson. “The COVID-19 pandemic has had a profound impact on adolescents, not just with the complications of the disease, but with their education, mental health, and wellbeing,” said Paul Stoffels, M.D., Vice Chairman of the Executive Committee and Chief Scientific Officer at Johnson & Johnson. “It is vital that we develop vaccines for eve...
Source: Johnson and Johnson - April 2, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Quick Consult: Symptom: Atraumatic Headache
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - April 1, 2021 Category: Emergency Medicine Tags: Quick Consult Source Type: news

Headache: Four changes in the weather that can induce headaches - how to prepare
HEADACHES can be brought on by bad weather conditions. According to the NHS, there are four weather events that can induce a headache. (Source: Daily Express - Health)
Source: Daily Express - Health - March 31, 2021 Category: Consumer Health News Source Type: news

POCUS achieves new heights in Mount Everest rescue
The patient's symptoms began at 12,600 feet with a minor headache on the sixt...Read more on AuntMinnie.comRelated Reading: AI can guide POCUS exams by novice users in the COVID ICU POCUS goes airborne at Canadian helicopter service What is POCUS? Leading rads call for new definition FDA clears Fujifilm Sonosite POCUS for COVID-19 use Fujifilm SonoSite launches new POCUS scanner (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 31, 2021 Category: Radiology Source Type: news

U.S. FDA Accepts AbbVie's New Drug Application for Atogepant for the Preventive Treatment of Migraine
NORTH CHICAGO, Ill., March 30, 2021 /PRNewswire/ -- AbbVie (NYSE: ABBV) today announced that the U.S. Food and Drug Administration (FDA) has accepted its New Drug Application (NDA) for atogepant, an investigational orally administered... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - March 30, 2021 Category: Drugs & Pharmacology Source Type: news

New tablet promises to prevent AND treat crippling migraines
One of those involved in the trials, Darlene LeBlanc, 63, from Florida describes how the drug was the first treatment she'd tried in over 40 years that worked well for her debilitating symptoms. (Source: the Mail online | Health)
Source: the Mail online | Health - March 30, 2021 Category: Consumer Health News Source Type: news

Remote Electrical Neuromodulation for Migraine in Adolescents Remote Electrical Neuromodulation for Migraine in Adolescents
Remote electrical neuromodulation is a novel non-pharmacological alternative treatment for acute migraine, FDA-approved for adults. Is it equally effective and safe for adolescents?Headache (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 29, 2021 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

How testosterone provided the cure for businesswoman's low libido and menopausal brain fog
Michelle Burgess' monthly hormonal migraines were lingering far longer than normal and she no longer had enthusiasm for anything - until she was prescribed HRT and testosterone. (Source: the Mail online | Health)
Source: the Mail online | Health - March 27, 2021 Category: Consumer Health News Source Type: news

Covid symptoms: Is it hay fever or coronavirus? A doctor tells all
COVID symptoms can include coughing, loss of smell, and a headache - all signs that may occur when hay fever flares up. How do you know when it's time to self isolate and book a Covid test? A doctor tells all. (Source: Daily Express - Health)
Source: Daily Express - Health - March 27, 2021 Category: Consumer Health News Source Type: news

Janssen Receives Positive CHMP Opinion for PONVORY ™ (ponesimod) for the Treatment of Adults With Relapsing Forms of Multiple Sclerosis With Active Disease Defined by Clinical or Imaging Features
BEERSE, BELGIUM, MARCH 26, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion recommending marketing authorisation for PONVORY™ (ponesimod) for the treatment of adult patients with relapsing multiple sclerosis (RMS) with active disease defined by clinical or imaging features.[3]“Relapsing forms of multiple sclerosis (MS) have varied and often unpredictable symptoms, posing a unique human, societal and economic burden,” said Catherine T...
Source: Johnson and Johnson - March 26, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Disputes leave AstraZeneca boss with chronic vaccine headache
Questions mount over whether Soriot’s dash and drive, which enthral investors, have resulted in missteps (Source: FT.com - Drugs and Healthcare)
Source: FT.com - Drugs and Healthcare - March 25, 2021 Category: Pharmaceuticals Source Type: news

Drug Combo Superior to Placebo for Posttraumatic Headache
THURSDAY, March 25, 2021 -- For patients with acute posttraumatic headache presenting to the emergency department, intravenous metoclopramide + diphenhydramine (M+D) is more efficacious than placebo, according to a study published online March 24 in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 25, 2021 Category: Pharmaceuticals Source Type: news

Oscars 'no Zoom' policy proving a headache for overseas nominees
Publicists and studio executives have reportedly complained about logistics, costs and quarantine issues (Source: Reuters: Health)
Source: Reuters: Health - March 25, 2021 Category: Consumer Health News Source Type: news

England's pubs may be allowed to ditch social distancing – as it happened
This blog is now closed. We ’ve launched a new blog at the link below:Coronavirus news – live12.11amGMTWe ’ve launched a new blog at the link below – head there for the latest:Related:Coronavirus live news: AstraZeneca to publish full vaccine trial results; US cases pass 30m12.08amGMTReuters reports that the “No Zoom” policy for this year’sOscars ceremony is proving a headache for multiple nominees who live outside the US and who are still under pandemic restrictions, according to Hollywood publications.Variety and Deadline Hollywood reported on Wednesday that publicists and some s...
Source: Guardian Unlimited Science - March 25, 2021 Category: Science Authors: Lucy Campbell (now); Clea Skopeliti, Tobi Thomas and Helen Sullivan (earlier) Tags: Coronavirus World news Infectious diseases Medical research Science Source Type: news

Covid vaccine: Side effects and why it can’t give you the virus
It's normal to experience some mild side effects, such as a headache or a raised temperature. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - March 25, 2021 Category: Consumer Health News Source Type: news

Triple Threat: Three Common Symptoms Add Up to One Rare Condition Triple Threat: Three Common Symptoms Add Up to One Rare Condition
Migraine, hearing loss, and blurred vision in a young woman had doctors baffled. Find out how these three common symptoms added up to one rare, very serious condition.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 24, 2021 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Understanding COVID-19 vaccine side effects, why second dose could feel worse
All vaccines could cause some degree of reaction, and the same is true for COVID-19 vaccines. Post-vaccine symptoms are typically mild and resolve quickly without the need to use any medication. Common COVID-19 vaccine side effects include: Redness or soreness at injection site.Muscle aches.Fatigue.Headache.Fever or chills. For some people, the second dose in a COVID-19 vaccine series [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - March 24, 2021 Category: Databases & Libraries Source Type: news

AstraZeneca vaccine headache: What causes Covid vaccine headache?
HEALTH officials have urged people to stay vigilant for a Covid vaccine side effect which could signal a deeper problem. What causes the Covid vaccine headache? (Source: Daily Express - Health)
Source: Daily Express - Health - March 22, 2021 Category: Consumer Health News Source Type: news

Dietary Magnesium and Migraine in Adults Dietary Magnesium and Migraine in Adults
Might an inadequate consumption of dietary magnesium play a role in migraine in U.S. adults?Headache (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 22, 2021 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Coronavirus new strain: Five signs you have a COVID-19 headache - 'pulsing, stabbing'
DAILY cases of coronavirus are still in the thousands, signalling that the virus will remain endemic despite the ongoing vaccination effort. Research suggested headaches are one of the earliest indicators of COVID-19. But how do they compare to regular ones? (Source: Daily Express - Health)
Source: Daily Express - Health - March 19, 2021 Category: Consumer Health News Source Type: news

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profi...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

AstraZeneca: UK and EU clot reviews confirm safety of vaccine
Regulators give reassurance and advice on rare blood clot symptoms, such as headache lasting days. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - March 18, 2021 Category: Consumer Health News Source Type: news

AstraZeneca vaccine headache: What headaches should you be wary of after MHRA warning?
THE OXFORD-ASTRAZENECA coronavirus vaccine has been subjected to much debate in recent days following reports of blood clots resulting from the vaccine. (Source: Daily Express - Health)
Source: Daily Express - Health - March 18, 2021 Category: Consumer Health News Source Type: news

AstraZeneca vaccine: UK regulator issues warning about headaches - seek medical attention
ASTRAZENECA is still on the defensive as reports that link its vaccine to blood clots continue to divide Europe. Meanwhile, the UK's drug regulator has urged people to seek medical help if they experience headache for more than four days after getting vaccinated. (Source: Daily Express - Health)
Source: Daily Express - Health - March 18, 2021 Category: Consumer Health News Source Type: news