Fight Aging! Newsletter, August 17th 2020

In this study, we sought to elucidate the role of VRK-1 in regulation of adult life span in C. elegans. We found that overexpression of VRK-1::GFP (green fluorescent protein), which was detected in the nuclei of cells in multiple somatic tissues, including the intestine, increased life span. Conversely, genetic inhibition of vrk-1 decreased life span. We further showed that vrk-1 was essential for the increased life span of mitochondrial respiratory mutants. We demonstrated that VRK-1 was responsible for increasing the level of active and phosphorylated form of AMPK, thus promoting longevity. A Fisetin Variant, CMS121, Slows Disease Progress in an Alzheimer's Mouse Model https://www.fightaging.org/archives/2020/08/a-fisetin-variant-cms121-slows-disease-progress-in-an-alzheimers-mouse-model/ The research materials here are of interest because fisetin has been shown to be a senolytic compound in mice, capable of selectively destroying harmful senescent cells. Other senolytics have reversed the progression of Alzheimer's disease pathology in mouse models of the condition. Destroying senescent cells in the brain reduces inflammatory signaling, and chronic inflammation is a significant mechanism in neurodegenerative conditions such as Alzheimer's disease. Whether this compound works well as a senolytic in humans has yet to be established - a clinical trial is underway, so hopefully we'll find out in the next year or two. The researchers here are not inter...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Conclusions: Our findings question the validity of using NIS and other administrative databases for health services and outcomes research that rely on certain diagnostic procedures. Unfortunately, the NIS does not provide granular data that can control for differences in diagnostic procedure use, which can lead to surveillance bias. Researchers and policy makers must understand and acknowledge the limitations inherent in these databases, when used for pay-for-performance initiatives and hospital benchmarking.
Source: Quality Management in Healthcare - Category: Health Management Tags: Original Articles Source Type: research
Conclusions: The findings suggest that the ANN model is a promising approach for predicting CHD risk and a good screening procedure to identify high-risk subjects.
Source: Quality Management in Healthcare - Category: Health Management Tags: Methods and Instruments Source Type: research
Conclusion: This article outlines the evaluation of a new program demonstrating that medical oncology practices can make improvements in the care of their underserved populations if provided with the proper tools, methods, and coaching. The use of formative evaluation methodology also identified opportunities for improvement and ultimately resulted in additional funding for more practices to participate in the program.
Source: Quality Management in Healthcare - Category: Health Management Tags: Methods and Instruments Source Type: research
ConclusionNPH ventricles deform non-uniformly. The pattern of surface distortion may be used as an additional tool to differentiate between these hydrocephalic conditions.
Source: Neuroradiology - Category: Radiology Source Type: research
ConclusionThe ddSVD algorithm better correlates with DWI follow-up infarct volume than DISD processing. The DISD algorithm overestimated larger ischemic cores which may lead to patient exclusion from thrombectomy based on selection by core volume.
Source: Neuroradiology - Category: Radiology Source Type: research
ConclusionThick (2 –3 mm) axial MIPs are not useful to detect proximal LVO in the anterior circulation.
Source: Neuroradiology - Category: Radiology Source Type: research
ConclusionNo clinical or radiographic complications are seen when performing MRI scans at 1.5 or 3 T on patients with implanted intracranial EEG electrodes while avoiding high specific energy absorption rate sequences.
Source: Neuroradiology - Category: Radiology Source Type: research
ConclusionsFollowing fetal myelomeningocele repair, brain volume, shape and SI were significantly different from normal in most cerebral layers. Morphological brain changes after fetal surgery are not limited to hindbrain herniation reversal. These findings may have neurocognitive outcome implications and require further evaluation.
Source: Neuroradiology - Category: Radiology Source Type: research
ConclusionThe results of this 10-year longitudinal study imply a positive correlation between long-standing hypertension and the progression of DWMLs.
Source: Neuroradiology - Category: Radiology Source Type: research
This study set out to assess for any such associations.Materials and methodsA retrospective review was completed of consecutive patients that had CTA neck imaging prior to CEA. Body mass index (BMI), tobacco and/or alcohol use, and history of diabetes and/or hypertension were collected from patients ’ medical records. Lab values were dichotomized based on values: total cholesterol
Source: Neuroradiology - Category: Radiology Source Type: research
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