Botanical drug is shown to help patients with head and neck cancers
In this study, UCLA researchers found that when APG-157 is taken through oral mucosal absorption, patients have high levels of curcumin circulating in their blood and absorbed by cancer tissues.METHODUCLA researchers conducted the study of APG-157 comparing 12 people who had oral and oropharyngeal cancer with a control group of 13 people who did not have cancer. The reason both the people with cancer and without cancer were part of the study was to show that the drug was not toxic to either people with cancer or those without cancer.The medication was given each hour for three hours and was delivered as a lozenge that slow...
Source: UCLA Newsroom: Health Sciences - February 6, 2020 Category: Universities & Medical Training Source Type: news

Microorganisms in the gut boost the immune system's ability to fight a herpes virus that can cause fatal brain inflammation
(Natural News) A recent study from the Beckman Research Institute in California revealed a surprising link between gut bacteria and inflammation. The findings, which were published in the journal Nature Communications, identified an envelope molecule from Bacteroides fragilis to have anti-inflammatory properties. According to the researchers, the molecule – which they called capsular polysaccharide A (PSA) – promotes protective and anti-inflammatory responses during... (Source:
Source: - November 23, 2019 Category: Consumer Health News Source Type: news

Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy
Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of myosin heavy chain 6–specific T helper (TH)1 and TH17 cells. However, mechanisms governing the cardiotoxicity programming of heart-specific T cells have remained elusive. Using a mouse model of spontaneous autoimmune myocarditis, we show that progression of myocarditis to lethal heart disease depends on cardiac myosin–specific TH17 cells imprinted in the intestine by a commensal Bacteroides species peptide mimic. Both the successful prevention of lethal disease in mice by antibiotic therapy and the significantly elevated Bac...
Source: ScienceNOW - November 14, 2019 Category: Science Authors: Gil-Cruz, C., Perez-Shibayama, C., De Martin, A., Ronchi, F., van der Borght, K., Niederer, R., Onder, L., Lütge, M., Novkovic, M., Nindl, V., Ramos, G., Arnoldini, M., Slack, E. M. C., Boivin-Jahns, V., Jahns, R., Wyss, M., Mooser, C., Lambrecht, Tags: Immunology, Medicine, Diseases reports Source Type: news

Gut microbiota utilize immunoglobulin A for mucosal colonization
The immune system responds vigorously to microbial infection while permitting lifelong colonization by the microbiome. Mechanisms that facilitate the establishment and stability of the gut microbiota remain poorly described. We found that a regulatory system in the prominent human commensal Bacteroides fragilis modulates its surface architecture to invite binding of immunoglobulin A (IgA) in mice. Specific immune recognition facilitated bacterial adherence to cultured intestinal epithelial cells and intimate association with the gut mucosal surface in vivo. The IgA response was required for B. fragilis (and other commensal...
Source: ScienceNOW - May 17, 2018 Category: Science Authors: Donaldson, G. P., Ladinsky, M. S., Yu, K. B., Sanders, J. G., Yoo, B. B., Chou, W.- C., Conner, M. E., Earl, A. M., Knight, R., Bjorkman, P. J., Mazmanian, S. K. Tags: Microbiology reports Source Type: news

Antibiotics Could Reduce Diarrhea, Improve Outcomes in Metastatic RCC
Patients who received Bacteroides-targeting antibiotics had a median PFS of 18 months compared with 8 months in patients with no antibiotic use. (Source: CancerNetwork)
Source: CancerNetwork - March 2, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Infection News Renal Cell Carcinoma Source Type: news

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria
Individuals with sporadic colorectal cancer (CRC) frequently harbor abnormalities in the composition of the gut microbiome; however, the microbiota associated with precancerous lesions in hereditary CRC remains largely unknown. We studied colonic mucosa of patients with familial adenomatous polyposis (FAP), who develop benign precursor lesions (polyps) early in life. We identified patchy bacterial biofilms composed predominately of Escherichia coli and Bacteroides fragilis. Genes for colibactin (clbB) and Bacteroides fragilis toxin (bft), encoding secreted oncotoxins, were highly enriched in FAP patients’ colonic muc...
Source: ScienceNOW - February 1, 2018 Category: Science Authors: Dejea, C. M., Fathi, P., Craig, J. M., Boleij, A., Taddese, R., Geis, A. L., Wu, X., DeStefano Shields, C. E., Hechenbleikner, E. M., Huso, D. L., Anders, R. A., Giardiello, F. M., Wick, E. C., Wang, H., Wu, S., Pardoll, D. M., Housseau, F., Sears, C. L. Tags: Medicine, Diseases, Microbiology reports Source Type: news

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
Colorectal cancers comprise a complex mixture of malignant cells, nontransformed cells, and microorganisms. Fusobacterium nucleatum is among the most prevalent bacterial species in colorectal cancer tissues. Here we show that colonization of human colorectal cancers with Fusobacterium and its associated microbiome—including Bacteroides, Selenomonas, and Prevotella species—is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors. In situ hybridization analysis revealed that Fusobacterium is predominantly associated with cancer cells in the metastatic les...
Source: ScienceNOW - December 14, 2017 Category: Science Authors: Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., Chipashvili, O., Hagan, T., Walker, M., Ramachandran, A., Diosdado, B., Serna, G., Mulet, N., Landolfi, S., Ramon y Cajal, S., Tags: Medicine, Diseases reports Source Type: news

Your baby ’s development depends on what is in their diaper
Researchers from the UNC School of Medicine found that high numbers of bacteria, known as bacteroides, are associated with youngsters performing better in cognitive tests at two years old. (Source: the Mail online | Health)
Source: the Mail online | Health - July 18, 2017 Category: Consumer Health News Source Type: news

Research suggests association between gut bacteria and emotion
FINDINGSResearchers have identified gut microbiota that interact with brain regions associated with mood and behavior.  This may be the first time that behavioral and neurobiological differences associated with microbial composition in healthy humans have been identified.BACKGROUNDBrain-gut-microbiota interactions may play an important role in human health and behavior. Previous research suggests that microbiota, a community of microorganisms in the gut, can influence behavior and emotion. Rodent models have demonstrated the effects of gut microbiota on emotional and social behaviors, such as anxiety and depression. T...
Source: UCLA Newsroom: Health Sciences - June 30, 2017 Category: Universities & Medical Training Source Type: news

Study suggests link between imbalanced gut microbiome and systemic sclerosis
This study is the first to examine gastrointestinal bacterial composition in two independent groups of people with systemic sclerosis. Systemic sclerosis, also known as scleroderma, is an autoimmune disease affecting the body ’s connective tissue. It is characterized by a hardening and scarring of skin and can progress to inflammation and scarring in the organs such as kidneys, heart, lungs and gastrointestinal tract. Previous UCLA-led research  detailed a link between the disease and the imbalance in the gut microbiome and suggested that this imbalance contributed to scleroderma’s symptoms.METHODThe ...
Source: UCLA Newsroom: Health Sciences - May 13, 2017 Category: Universities & Medical Training Source Type: news

Infant bronchiolitis risk linked to gut flora composition
Infants with gut flora dominated by the genus Bacteroides have more than four times greater odds of developing bronchiolitis than those with microbiota dominated by Enterobacter and... (Source: Family Practice News)
Source: Family Practice News - June 27, 2016 Category: Primary Care Source Type: news

Distinct Fecal Microbiota Pattern Associated with Infant Bronchiolitis (FREE)
By Christine Judge Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH A gut microbiota dominated by Bacteroides is associated with elevated risk for bronchiolitis in infants, suggests a case-control study in Pediatrics.Investigators matched 40 infants hospitalized with … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - June 27, 2016 Category: Primary Care Source Type: news

[Report] Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
Inflammatory bowel disease (IBD) is associated with risk variants in the human genome and dysbiosis of the gut microbiome, though unifying principles for these findings remain largely undescribed. The human commensal Bacteroides fragilis delivers immunomodulatory molecules to immune cells via secretion of outer membrane vesicles (OMVs). We reveal that OMVs require IBD-associated genes, ATG16L1 and NOD2, to activate a noncanonical autophagy pathway during protection from colitis. ATG16L1-deficient dendritic cells do not induce regulatory T cells (Tregs) to suppress mucosal inflammation. Immune cells from human subjects with...
Source: ScienceNOW - May 27, 2016 Category: Science Authors: Hiutung Chu Source Type: news

[Report] Helminth infection promotes colonization resistance via type 2 immunity
Increasing incidence of inflammatory bowel diseases, such as Crohn’s disease, in developed nations is associated with changes to the microbial environment, such as decreased prevalence of helminth colonization and alterations to the gut microbiota. We find that helminth infection protects mice deficient in the Crohn’s disease susceptibility gene Nod2 from intestinal abnormalities by inhibiting colonization by an inflammatory Bacteroides species. Resistance to Bacteroides colonization was dependent on type 2 immunity, which promoted the establishment of a protective microbiota enriched in Clostridiales. Addition...
Source: ScienceNOW - April 29, 2016 Category: Science Authors: Deepshika Ramanan Source Type: news

New Technique Could Give C-Section Babies The Benefits Of Vaginal Birth
In a new procedure, doctors wiped down the skin of newborns delivered by cesarean section with a gauze carrying their mothers' vaginal fluid. The doctors found that this was a successful way to transfer beneficial microbes from pregnant women to their infants, a new pilot study suggests. This small study showed that this swabbing procedure, known as vaginal microbial transfer, can safely and effectively change the microbial communities of babies delivered by C-section to make them more closely resemble those of vaginally born babies, said José Clemente, an assistant professor of genetics at the Icahn School of Medic...
Source: Science - The Huffington Post - February 2, 2016 Category: Science Source Type: news

Medical News Today: Scientists 'hack' common gut bacterium
Researchers have engineered a common gut bacterium called Bacteroides thetaiotaomicron, which allowed the scientists to control gene expression in mice. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 10, 2015 Category: Consumer Health News Tags: GastroIntestinal / Gastroenterology Source Type: news

At the University of Michigan, Research Study Indicates how Composition of Gut Microbiome May Serve as Complementary, Noninvasive Screening Tool for Colon Cancer
If validated by additional research, microbiologists, pathologists, and medical laboratory professionals might soon find analysis of the human microbiome to be a useful marker in screening for colon cancer Microbiologists may play a greater role in the early detection of colorectal cancer, if the findings of a research study at the University of Michigan (UMich) […] (Source: Dark Daily)
Source: Dark Daily - November 26, 2014 Category: Laboratory Medicine Authors: jude Tags: Instruments & Equipment Laboratory Management and Operations Laboratory News Laboratory Operations Laboratory Pathology Management & Operations Adenoma and End Results program AUC Bacteroides Bayesian methods BMI body mass index Source Type: news

UCLA-led study identifies genetic factors involved in pediatric ulcerative colitis
UCLA researchers were part of a team that has discovered the interplay of several genetic factors that may be involved in the development of early-onset ulcerative colitis, a severe type of inflammatory bowel disease. The early research findings may offer new targets for prevention and treatment strategies to address the inflammation generated by early-onset ulcerative colitis. The rare disease affects infants and young children and can lead to early development of colon cancer and an increased risk of liver damage. Scientists from the David Geffen School of Medicine at UCLA and Pusan National University in South Korea als...
Source: UCLA Newsroom: Health Sciences - September 3, 2014 Category: Universities & Medical Training Source Type: news

Common bacteria could help prevent food allergies
ConclusionThis research examined how normal populations of gut bacteria influence mouse susceptibility to peanut allergens. The findings suggest the Clostridia group of bacteria may have a particular role in altering the immune defenses of the gut lining and preventing some of the food allergen entering the bloodstream. The findings inform the theory that our increasingly sterile environments and increased use of antibiotics could lead to a reduction in our normal gut bacteria, which could possibly lead to people developing a sensitivity to allergens.But these findings are in the very early stages. So far, only mice have b...
Source: NHS News Feed - August 26, 2014 Category: Consumer Health News Tags: Food/diet Medical practice Source Type: news

Newly discovered gut virus lives in half the world's population
Odds are, there's a virus living inside your gut that has gone undetected by scientists for decades. A new study has found that more than half the world's population is host to a newly described virus, named crAssphage, which infects one of the most common gut bacterial species, Bacteroides. This bacterium thought to be connected with obesity, diabetes and other gut-related diseases. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 24, 2014 Category: Science Source Type: news

Good bacteria armed with antibiotic resistance protect gut microbiome
(American Society for Microbiology) Researchers from Case Western Reserve University in Cleveland have discovered that populating the gastrointestinal tracts of mice with Bacteroides species producing a specific enzyme helps protect the good commensal bacteria from the harmful effects of antibiotics. Their research is published ahead of print in Antimicrobial Agents and Chemotherapy. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 12, 2014 Category: Infectious Diseases Source Type: news

I had the bacteria in my gut analysed. And this may be the future of medicine
Andrew Anthony sent his stool off to have its bacteria sequenced. In the future, such techniques could help assess our susceptibility to conditions from diabetes, Parkinson's and Alzheimer's to autism, depression and cancerWe are all familiar with "gut feelings", "gut reactions" and "gut instincts", but how much do we really know or care about our guts? As we become increasingly more aware of what we put in our stomachs, it's striking how ignorant we remain of what takes place in our intestines. And it turns out there is an awful lot going on down there.Microbiologists have made some startling...
Source: Guardian Unlimited Science - February 11, 2014 Category: Science Authors: Andrew Anthony Tags: Biology Health Microbiology & wellbeing Human biology Features Antibiotics Life and style The Observer Biochemistry and molecular biology Science Source Type: news

Human Fecal Source Identification with Real-Time Quantitative PCR
We describe a real-time quantitative PCR (qPCR) method that targets a genetic marker of the human-associated Bacteroides dorei for identification of human fecal pollution in ambient water samples. The following protocol includes water sample collection, filtration, DNA isolation with a sample processing control, qPCR amplification with an internal amplification control, and quality control data analysis. (Source: Springer protocols feed by Microbiology)
Source: Springer protocols feed by Microbiology - January 1, 2014 Category: Microbiology Source Type: news

What Organisms Cause Acute Epiglottitis in the Post- H. influenza Vaccination Era?
Discussion Epiglottitis is also known as supraglottitis and is caused by inflammation of the supraglottic structures and epiglottis. Usually the cause is infectious but other trauma such as thermal injuries or ingestions can also cause the disease. Before the widespread use of its conjugated immunization, Haemophilus influenza type b was the most common cause and it was usually thought of as a pediatric disease process. In the pre-immunization time period, acute epiglottitis in children was 3.47-6.0 cases per 100,000, and in the post-immunization period has declined to 0.3-0.7 cases per 100,000. However it appears that
Source: - October 7, 2013 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

What Organisms Cause Acute Epiglottitis in the Post- H. influenza Vaccination Era?
Discussion Epiglottitis is also known as supraglottitis and is caused by inflammation of the supraglottic structures and epiglottis. Usually the cause is infectious but other trauma such as thermal injuries or ingestions can also cause the disease. Before the widespread use of its conjugated immunization, Haemophilus influenza type b was the most common cause and it was usually thought of as a pediatric disease process. In the pre-immunization time period, acute epiglottitis in children was 3.47-6.0 cases per 100,000, and in the post-immunization period has declined to 0.3-0.7 cases per 100,000. However it appears that
Source: - October 7, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Multidrug-Resistant Bacteroides fragilisMultidrug-Resistant Bacteroides fragilis
One of the leading pathogens isolated in the setting of intra-abdominal infections, B. fragilis strains are virtually always susceptible to metronidazole, carbapenems, and beta-lactam antibiotics -- except when they're not . . . Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 1, 2013 Category: Consumer Health News Tags: Public Health & Prevention Journal Article Source Type: news

Multidrug-Resistant Bacteroides fragilis — Seattle, Washington, 2013
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - August 29, 2013 Category: American Health Source Type: news

What Are the Potential Complications of a Retropharyngeal Abscess?
Discussion Retropharyngeal abscesses (RPA) occur in the potential space bound anterior to the prevertebral fascia, posterior to the pharyngeal constrictor muscles and their fascia and laterally by the carotid sheaths and parapharyngeal space (another potential space lying laterally to the pharynx). The retropharyngeal potential space runs superiorally from the base of the skull to the mediastinum distally. It is the most common deep neck infection. In children under 4 years of age, retropharyngeal lymph nodes are present which regress after this age. RPA is most common in young children when these lymph nodes are present, ...
Source: - May 27, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news