Bacteroides fight fatty liver
Sphingolipids from commensal bacteria transit to the liver and normalize lipid accumulation in a mouse model of hepatic steatosis. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - June 28, 2022 Category: Science Source Type: news

What is the Difference Between a Paronychia and a Felon?
Discussion The hands are one of the most important parts of the body for interacting with the world. They are remarkably adapted having sensitive sensory receptors as well as feedback receptors for grasping, holding, and manipulating objects. Hands, especially with an opposable thumb, multiple joints within the hand, along with the wrist and elbow, allow the hand to move in multiple positions to manipulate the world. Hands also symbolize an emotional caring and sharing between individuals as hands are used to provide a true “human touch” in personal and social situations. Due to their important interactions in ...
Source: - December 6, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Restoring gut microbes missing in early life dysbiosis can reduce risk of colitis in mice
(University of Chicago Medical Center) A new study at the University of Chicago has determined that restoring a single microbial species -- Bacteroides sp. CL1-UC (Bc) -- to the gut microbiome at a key developmental timepoint can prevent antibiotic-induced colitis in a mouse model of the condition. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 7, 2021 Category: Biology Source Type: news

How Common are Co-infections with Trichomonas and Bacterial Vaginosis?
Discussion Vulvovaginitis is a common gynecological complaint for females of all ages. It is specifically the inflammation of the vulva and vagina but is used as a general term often to mean vulvar irritation, itching, and burning that can occur with or without vaginal discharge. In prepubertal females there is lack of estrogenization, and less lactobacillus species which creates a more neutral pH (normal vaginal pH is < 4.5), lack of pubic hair and fat pad which provide trauma protection, location of anus close to the vagina and tendency of poor hygiene in young children. With puberty, estrogen thickens the vaginal tis...
Source: - May 24, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Botanical drug is shown to help patients with head and neck cancers
In this study, UCLA researchers found that when APG-157 is taken through oral mucosal absorption, patients have high levels of curcumin circulating in their blood and absorbed by cancer tissues.METHODUCLA researchers conducted the study of APG-157 comparing 12 people who had oral and oropharyngeal cancer with a control group of 13 people who did not have cancer. The reason both the people with cancer and without cancer were part of the study was to show that the drug was not toxic to either people with cancer or those without cancer.The medication was given each hour for three hours and was delivered as a lozenge that slow...
Source: UCLA Newsroom: Health Sciences - February 6, 2020 Category: Universities & Medical Training Source Type: news

Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy
Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of myosin heavy chain 6–specific T helper (TH)1 and TH17 cells. However, mechanisms governing the cardiotoxicity programming of heart-specific T cells have remained elusive. Using a mouse model of spontaneous autoimmune myocarditis, we show that progression of myocarditis to lethal heart disease depends on cardiac myosin–specific TH17 cells imprinted in the intestine by a commensal Bacteroides species peptide mimic. Both the successful prevention of lethal disease in mice by antibiotic therapy and the significantly elevated Bac...
Source: ScienceNOW - November 13, 2019 Category: Science Authors: Gil-Cruz, C., Perez-Shibayama, C., De Martin, A., Ronchi, F., van der Borght, K., Niederer, R., Onder, L., Lütge, M., Novkovic, M., Nindl, V., Ramos, G., Arnoldini, M., Slack, E. M. C., Boivin-Jahns, V., Jahns, R., Wyss, M., Mooser, C., Lambrecht, Tags: Immunology, Medicine, Diseases reports Source Type: news

Gut microbiota utilize immunoglobulin A for mucosal colonization
The immune system responds vigorously to microbial infection while permitting lifelong colonization by the microbiome. Mechanisms that facilitate the establishment and stability of the gut microbiota remain poorly described. We found that a regulatory system in the prominent human commensal Bacteroides fragilis modulates its surface architecture to invite binding of immunoglobulin A (IgA) in mice. Specific immune recognition facilitated bacterial adherence to cultured intestinal epithelial cells and intimate association with the gut mucosal surface in vivo. The IgA response was required for B. fragilis (and other commensal...
Source: ScienceNOW - May 17, 2018 Category: Science Authors: Donaldson, G. P., Ladinsky, M. S., Yu, K. B., Sanders, J. G., Yoo, B. B., Chou, W.- C., Conner, M. E., Earl, A. M., Knight, R., Bjorkman, P. J., Mazmanian, S. K. Tags: Microbiology reports Source Type: news

Antibiotics Could Reduce Diarrhea, Improve Outcomes in Metastatic RCC
Patients who received Bacteroides-targeting antibiotics had a median PFS of 18 months compared with 8 months in patients with no antibiotic use. (Source: CancerNetwork)
Source: CancerNetwork - March 2, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Infection News Renal Cell Carcinoma Source Type: news

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria
Individuals with sporadic colorectal cancer (CRC) frequently harbor abnormalities in the composition of the gut microbiome; however, the microbiota associated with precancerous lesions in hereditary CRC remains largely unknown. We studied colonic mucosa of patients with familial adenomatous polyposis (FAP), who develop benign precursor lesions (polyps) early in life. We identified patchy bacterial biofilms composed predominately of Escherichia coli and Bacteroides fragilis. Genes for colibactin (clbB) and Bacteroides fragilis toxin (bft), encoding secreted oncotoxins, were highly enriched in FAP patients’ colonic muc...
Source: ScienceNOW - February 1, 2018 Category: Science Authors: Dejea, C. M., Fathi, P., Craig, J. M., Boleij, A., Taddese, R., Geis, A. L., Wu, X., DeStefano Shields, C. E., Hechenbleikner, E. M., Huso, D. L., Anders, R. A., Giardiello, F. M., Wick, E. C., Wang, H., Wu, S., Pardoll, D. M., Housseau, F., Sears, C. L. Tags: Medicine, Diseases, Microbiology reports Source Type: news

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
Colorectal cancers comprise a complex mixture of malignant cells, nontransformed cells, and microorganisms. Fusobacterium nucleatum is among the most prevalent bacterial species in colorectal cancer tissues. Here we show that colonization of human colorectal cancers with Fusobacterium and its associated microbiome—including Bacteroides, Selenomonas, and Prevotella species—is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors. In situ hybridization analysis revealed that Fusobacterium is predominantly associated with cancer cells in the metastatic les...
Source: ScienceNOW - December 14, 2017 Category: Science Authors: Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., Chipashvili, O., Hagan, T., Walker, M., Ramachandran, A., Diosdado, B., Serna, G., Mulet, N., Landolfi, S., Ramon y Cajal, S., Tags: Medicine, Diseases reports Source Type: news

Your baby ’s development depends on what is in their diaper
Researchers from the UNC School of Medicine found that high numbers of bacteria, known as bacteroides, are associated with youngsters performing better in cognitive tests at two years old. (Source: the Mail online | Health)
Source: the Mail online | Health - July 18, 2017 Category: Consumer Health News Source Type: news

Research suggests association between gut bacteria and emotion
FINDINGSResearchers have identified gut microbiota that interact with brain regions associated with mood and behavior.  This may be the first time that behavioral and neurobiological differences associated with microbial composition in healthy humans have been identified.BACKGROUNDBrain-gut-microbiota interactions may play an important role in human health and behavior. Previous research suggests that microbiota, a community of microorganisms in the gut, can influence behavior and emotion. Rodent models have demonstrated the effects of gut microbiota on emotional and social behaviors, such as anxiety and depression. There...
Source: UCLA Newsroom: Health Sciences - June 29, 2017 Category: Universities & Medical Training Source Type: news

Study suggests link between imbalanced gut microbiome and systemic sclerosis
This study is the first to examine gastrointestinal bacterial composition in two independent groups of people with systemic sclerosis. Systemic sclerosis, also known as scleroderma, is an autoimmune disease affecting the body ’s connective tissue. It is characterized by a hardening and scarring of skin and can progress to inflammation and scarring in the organs such as kidneys, heart, lungs and gastrointestinal tract. Previous UCLA-led research  detailed a link between the disease and the imbalance in the gut microbiome and suggested that this imbalance contributed to scleroderma’s symptoms.METHODThe researchers stud...
Source: UCLA Newsroom: Health Sciences - May 12, 2017 Category: Universities & Medical Training Source Type: news

Infant bronchiolitis risk linked to gut flora composition
Infants with gut flora dominated by the genus Bacteroides have more than four times greater odds of developing bronchiolitis than those with microbiota dominated by Enterobacter and... (Source: Family Practice News)
Source: Family Practice News - June 27, 2016 Category: Primary Care Source Type: news