Distinct Fecal Microbiota Pattern Associated with Infant Bronchiolitis (FREE)
By Christine Judge Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH A gut microbiota dominated by Bacteroides is associated with elevated risk for bronchiolitis in infants, suggests a case-control study in Pediatrics.Investigators matched 40 infants hospitalized with … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - June 26, 2016 Category: Primary Care Source Type: news
[Report] Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
Inflammatory bowel disease (IBD) is associated with risk variants in the human genome and dysbiosis of the gut microbiome, though unifying principles for these findings remain largely undescribed. The human commensal Bacteroides fragilis delivers immunomodulatory molecules to immune cells via secretion of outer membrane vesicles (OMVs). We reveal that OMVs require IBD-associated genes, ATG16L1 and NOD2, to activate a noncanonical autophagy pathway during protection from colitis. ATG16L1-deficient dendritic cells do not induce regulatory T cells (Tregs) to suppress mucosal inflammation. Immune cells from human subjects with...
Source: ScienceNOW - May 26, 2016 Category: Science Authors: Hiutung Chu Source Type: news
[Report] Helminth infection promotes colonization resistance via type 2 immunity
Increasing incidence of inflammatory bowel diseases, such as Crohn’s disease, in developed nations is associated with changes to the microbial environment, such as decreased prevalence of helminth colonization and alterations to the gut microbiota. We find that helminth infection protects mice deficient in the Crohn’s disease susceptibility gene Nod2 from intestinal abnormalities by inhibiting colonization by an inflammatory Bacteroides species. Resistance to Bacteroides colonization was dependent on type 2 immunity, which promoted the establishment of a protective microbiota enriched in Clostridiales. Additionally, we...
Source: ScienceNOW - April 28, 2016 Category: Science Authors: Deepshika Ramanan Source Type: news
New Technique Could Give C-Section Babies The Benefits Of Vaginal Birth
In a new procedure, doctors wiped down the skin of newborns delivered by cesarean section with a gauze carrying their mothers' vaginal fluid. The doctors found that this was a successful way to transfer beneficial microbes from pregnant women to their infants, a new pilot study suggests. This small study showed that this swabbing procedure, known as vaginal microbial transfer, can safely and effectively change the microbial communities of babies delivered by C-section to make them more closely resemble those of vaginally born babies, said José Clemente, an assistant professor of genetics at the Icahn School of Medicin...
Source: Science - The Huffington Post - February 2, 2016 Category: Science Source Type: news
Medical News Today: Scientists 'hack' common gut bacterium
Researchers have engineered a common gut bacterium called Bacteroides thetaiotaomicron, which allowed the scientists to control gene expression in mice. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 10, 2015 Category: Consumer Health News Tags: GastroIntestinal / Gastroenterology Source Type: news
At the University of Michigan, Research Study Indicates how Composition of Gut Microbiome May Serve as Complementary, Noninvasive Screening Tool for Colon Cancer
If validated by additional research, microbiologists, pathologists, and medical laboratory professionals might soon find analysis of the human microbiome to be a useful marker in screening for colon cancer Microbiologists may play a greater role in the early detection of colorectal cancer, if the findings of a research study at the University of Michigan (UMich) […] (Source: Dark Daily)
Source: Dark Daily - November 26, 2014 Category: Laboratory Medicine Authors: jude Tags: Instruments & Equipment Laboratory Management and Operations Laboratory News Laboratory Operations Laboratory Pathology Management & Operations Adenoma and End Results program AUC Bacteroides Bayesian methods BMI body mass index Source Type: news
UCLA-led study identifies genetic factors involved in pediatric ulcerative colitis
UCLA researchers were part of a team that has discovered the interplay of several genetic factors that may be involved in the development of early-onset ulcerative colitis, a severe type of inflammatory bowel disease. The early research findings may offer new targets for prevention and treatment strategies to address the inflammation generated by early-onset ulcerative colitis. The rare disease affects infants and young children and can lead to early development of colon cancer and an increased risk of liver damage. Scientists from the David Geffen School of Medicine at UCLA and Pusan National University in South Korea als...
Source: UCLA Newsroom: Health Sciences - September 3, 2014 Category: Universities & Medical Training Source Type: news
Common bacteria could help prevent food allergies
ConclusionThis research examined how normal populations of gut bacteria influence mouse susceptibility to peanut allergens. The findings suggest the Clostridia group of bacteria may have a particular role in altering the immune defenses of the gut lining and preventing some of the food allergen entering the bloodstream. The findings inform the theory that our increasingly sterile environments and increased use of antibiotics could lead to a reduction in our normal gut bacteria, which could possibly lead to people developing a sensitivity to allergens.But these findings are in the very early stages. So far, only mice have b...
Source: NHS News Feed - August 26, 2014 Category: Consumer Health News Tags: Food/diet Medical practice Source Type: news
Newly discovered gut virus lives in half the world's population
Odds are, there's a virus living inside your gut that has gone undetected by scientists for decades. A new study has found that more than half the world's population is host to a newly described virus, named crAssphage, which infects one of the most common gut bacterial species, Bacteroides. This bacterium thought to be connected with obesity, diabetes and other gut-related diseases. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 24, 2014 Category: Science Source Type: news
Good bacteria armed with antibiotic resistance protect gut microbiome
(American Society for Microbiology) Researchers from Case Western Reserve University in Cleveland have discovered that populating the gastrointestinal tracts of mice with Bacteroides species producing a specific enzyme helps protect the good commensal bacteria from the harmful effects of antibiotics. Their research is published ahead of print in Antimicrobial Agents and Chemotherapy. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 12, 2014 Category: Infectious Diseases Source Type: news
I had the bacteria in my gut analysed. And this may be the future of medicine
Andrew Anthony sent his stool off to have its bacteria sequenced. In the future, such techniques could help assess our susceptibility to conditions from diabetes, Parkinson's and Alzheimer's to autism, depression and cancerWe are all familiar with "gut feelings", "gut reactions" and "gut instincts", but how much do we really know or care about our guts? As we become increasingly more aware of what we put in our stomachs, it's striking how ignorant we remain of what takes place in our intestines. And it turns out there is an awful lot going on down there.Microbiologists have made some startling advances in revealing our inn...
Source: Guardian Unlimited Science - February 11, 2014 Category: Science Authors: Andrew Anthony Tags: Biology Health Microbiology & wellbeing Human biology Features Antibiotics Life and style The Observer Biochemistry and molecular biology Science Source Type: news
Human Fecal Source Identification with Real-Time Quantitative PCR
We describe a real-time quantitative PCR (qPCR) method that targets a genetic marker of the human-associated Bacteroides dorei for identification of human fecal pollution in ambient water samples. The following protocol includes water sample collection, filtration, DNA isolation with a sample processing control, qPCR amplification with an internal amplification control, and quality control data analysis. (Source: Springer protocols feed by Microbiology)
Source: Springer protocols feed by Microbiology - January 1, 2014 Category: Microbiology Source Type: news
What Organisms Cause Acute Epiglottitis in the Post- H. influenza Vaccination Era?
Discussion Epiglottitis is also known as supraglottitis and is caused by inflammation of the supraglottic structures and epiglottis. Usually the cause is infectious but other trauma such as thermal injuries or ingestions can also cause the disease. Before the widespread use of its conjugated immunization, Haemophilus influenza type b was the most common cause and it was usually thought of as a pediatric disease process. In the pre-immunization time period, acute epiglottitis in children was 3.47-6.0 cases per 100,000, and in the post-immunization period has declined to 0.3-0.7 cases per 100,000. However it appears that <...
Source: PediatricEducation.org - October 7, 2013 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
What Organisms Cause Acute Epiglottitis in the Post- H. influenza Vaccination Era?
Discussion Epiglottitis is also known as supraglottitis and is caused by inflammation of the supraglottic structures and epiglottis. Usually the cause is infectious but other trauma such as thermal injuries or ingestions can also cause the disease. Before the widespread use of its conjugated immunization, Haemophilus influenza type b was the most common cause and it was usually thought of as a pediatric disease process. In the pre-immunization time period, acute epiglottitis in children was 3.47-6.0 cases per 100,000, and in the post-immunization period has declined to 0.3-0.7 cases per 100,000. However it appears that < 1...
Source: PediatricEducation.org - October 7, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news
Multidrug-Resistant Bacteroides fragilisMultidrug-Resistant Bacteroides fragilis
One of the leading pathogens isolated in the setting of intra-abdominal infections, B. fragilis strains are virtually always susceptible to metronidazole, carbapenems, and beta-lactam antibiotics -- except when they're not . . . Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 1, 2013 Category: Consumer Health News Tags: Public Health & Prevention Journal Article Source Type: news