Study suggests link between imbalanced gut microbiome and systemic sclerosis
This study is the first to examine gastrointestinal bacterial composition in two independent groups of people with systemic sclerosis. Systemic sclerosis, also known as scleroderma, is an autoimmune disease affecting the body ’s connective tissue. It is characterized by a hardening and scarring of skin and can progress to inflammation and scarring in the organs such as kidneys, heart, lungs and gastrointestinal tract. Previous UCLA-led research detailed a link between the disease and the imbalance in the gut microbiome and suggested that this imbalance contributed to scleroderma’s symptoms.METHODThe researchers studied 17 adults with systemic sclerosis from UCLA, 17 from Oslo University Hospital, and 17 healthy adults as the control group. All participants provided stool specimens, which the researchers tested to determine the type and abundance of specific bacteria present. The people with systemic sclerosis had significantly lower levels of gut bacteria believed to protect against inflammation, such as Bacteroides (UCLA and Oslo), Faecalibacterium (UCLA) and Clostridium (Oslo). They also had significantly higher levels of bacteria that promote inflammation, such as Fusobacterium (UCLA), compared with those in the control group. Increased levels of Clostridium was associated with less severe gastrointestinal tract symptoms in the groups of people with systemic sclerosis from UCLA and Oslo.IMPACTThe findings may help to shed light on the cause of system...
Publication date: Available online 18 April 2019Source: NeurocomputingAuthor(s): Hai Xie, Haijun Lei, Yejun He, Baiying LeiAbstractHuman Epithelial-2 (HEp-2) cell images play an important role for the detection of antinuclear autoantibodies (ANA) in autoimmune diseases. Segmentation is the primary step for classification, further treatment and diagnosis. However, the staining patterns and scales of HEp-2 specimen images have different variances, which still make segmentation quite a challenging task. To solve it, we propose a novel deeply supervised full convolutional network (DSFCN) for robust segmentation of different HE...
PMID: 30992122 [PubMed - in process]
Publication date: 1 July 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 179Author(s): Seiichi Ohta, Mai Matsuura, Yuta Kawashima, Xinyu Cai, Machiko Taniguchi, Hitoshi Okochi, Yoshihide Asano, Shinichi Sato, Taichi ItoAbstractWe developed a facile fabrication method for preparing poly(ethylene glycol)(PEG)-coated poly (lactic-co-glycolic acid) (PLGA) microspheres with homogeneous size distribution via a combination of mPEG-b-PLGA and Shirasu Porous Glass membrane emulsification. Subsequently, extracellular matrix (ECM) degrading enzymes, collagenase (COLase) or hyaluronidase (HAse) were loaded into the microsph...
Viela Bio Inc. has earned a breakthrough therapy designation from the Food and Drug Administration for a product to treat neuromyelitis optica spectrum disorder, a life-threatening autoimmune disease that impacts the central nervous system. The FDA granted breakthrough status to the company’s candidate, inebilizumab, following positive results from a pivotal study that was “the largest monotherapy study ever conducted in NMOSD,” said Dr. Jorn Drappa, chief medical officer and head of research…
A 38-year-old man with a history of end-stage renal disease due to congenital vesicoureteral reflux underwent transplantation of a deceased donor kidney with good graft function thereafter. Alemtuzumab was used for induction immunosuppression, followed by maintenance immunosuppression consisting of mycophenolate mofetil, tacrolimus, and prednisone. Aerosolized pentamidine was used for posttransplant Pneumocystis jirovecii prophylaxis instead of the standard therapy with trimethoprim-sulfamethoxazole because of hyperkalemia associated with trimethoprim-sulfamethoxazole.
Conditions: Diabetes Mellitus; Quality of Life Intervention: Procedure: Solid Organ Pancreas Transplantation with or without Kidney Transplantation Sponsor: University of Oxford Recruiting
Condition: Fluid Response Intervention: Device: Massimo for Pleth variability index Sponsor: Ain Shams University Recruiting
Condition: Acute Myeloid Leukemia Interventions: Procedure: Biospecimen Collection; Other: Laboratory Biomarker Analysis Sponsors: University of Southern California; National Cancer Institute (NCI) Recruiting
Conditions: Hematologic Disease; Neoplams; Transplantation; Immunologic Deficiency Syndromes; Critical Illness Intervention: Sponsor: University Hospital, Strasbourg, France Recruiting
Condition: Allogeneic Hematopoietic Stem Cell Transplantation Recipient Interventions: Other: Best Practice; Drug: CBM588 Sponsors: City of Hope Medical Center; National Cancer Institute (NCI) Recruiting
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