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Study suggests link between imbalanced gut microbiome and systemic sclerosis

This study is the first to examine gastrointestinal bacterial composition in two independent groups of people with systemic sclerosis. Systemic sclerosis, also known as scleroderma, is an autoimmune disease affecting the body ’s connective tissue. It is characterized by a hardening and scarring of skin and can progress to inflammation and scarring in the organs such as kidneys, heart, lungs and gastrointestinal tract. Previous UCLA-led research  detailed a link between the disease and the imbalance in the gut microbiome and suggested that this imbalance contributed to scleroderma’s symptoms.METHODThe researchers studied 17 adults with systemic sclerosis from UCLA, 17 from Oslo University Hospital, and 17 healthy adults as the control group. All participants provided stool specimens, which the researchers tested to determine the type and abundance of specific bacteria present. The people with systemic sclerosis had significantly lower levels of gut bacteria believed to protect against inflammation, such as Bacteroides (UCLA and Oslo), Faecalibacterium (UCLA) and Clostridium (Oslo). They also had significantly higher levels of bacteria that promote inflammation, such as Fusobacterium (UCLA), compared with those in the control group. Increased levels of Clostridium was associated with less severe gastrointestinal tract symptoms in the groups of people with systemic sclerosis from UCLA and Oslo.IMPACTThe findings may help to shed light on the cause of system...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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This study investigated the possible therapeutic effects of PZH on experimental autoimmune encephalomyelitis (EAE) rats, a classic animal model of MS. Male Lewis rats were immunized with myelin basic protein (MBP) peptide to establish an EAE model and then treated with three doses of PZH. Clinical symptoms, organ coefficient, histopathological features, levels of proinflammatory cytokines, and chemokines as well as MBP and Olig2 were analyzed. The results indicated that PZH ameliorated the clinical severity of EAE rats. It also remarkably reduced inflammatory cell infiltration in the CNS of EAE rats. Furthermore, the level...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Functional bowel disorders (FBD) resemble a group of diseases of the gastrointestinal (GI) tract that are without a clear pathogenesis; the best known is probably the “irritable bowel syndrome” (IBS). Only recently we have been able to explore the role of the gut microbiota in FBD due to progress in microbiological analytic techniques. There are different ways to explore the role of the gut microbiota and its dysbiosis in FBD. Comparison of the microbial comp osition in a group of patients with FBD, for example, with IBS to a group of healthy volunteers is one way. Studies have shown that the microbiota in FBD ...
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
We present a boy with a genetically proven congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. While massively elevated 17-hydroxyprogesterone (17-OHP) concentrations after birth led to the diagnosis, 17-OHP concentrations became immeasurable starting with the second year of life even though the dose of hydrocortisone was continuously decreased to ∼7 mg/m2/day. Furthermore, 17-OHP levels were immeasurable during the ACTH test and after withdrawing hydrocortisone medication. In contrast, ACTH levels increased after cessation of hydrocortisone treatment suggesting complete primary adrenal cortex failur...
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research
Contributors : Hyun Park ; Mira Jeong ; Margaret Goodell ; Grant ChallenSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusRecent epidemiological studies have shown that cancer-associated DNMT3A mutations can be detected in the blood of a large proportion of asymptotic elderly individuals. It is important to understand how these mutations provide a competitive advantage to HSCs and allow them to establish clonal dominance. Here we demonstrate that the stress of serial HSC transplantation immortalizes Dnmt3a-null HSCs.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Hyun Park ; Mira Jeong ; Margaret Goodell ; Grant ChallenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusRecent epidemiological studies have shown that cancer-associated DNMT3A mutations can be detected in the blood of a large proportion of asymptotic elderly individuals. It is important to understand how these mutations provide a competitive advantage to HSCs and allow them to establish clonal dominance. Here we demonstrate that the stress of serial HSC transplantation immortalizes Dnmt3a-null HSCs.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Hyun Park ; Mira Jeong ; Margaret Goodell ; Grant ChallenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRecent epidemiological studies have shown that cancer-associated DNMT3A mutations can be detected in the blood of a large proportion of asymptotic elderly individuals. It is important to understand how these mutations provide a competitive advantage to HSCs and allow them to establish clonal dominance. Here we demonstrate that the stress of serial HSC transplantation immortalizes Dnmt3a-null HSCs.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
(Medical College of Georgia at Augusta University) A daily dose of baking soda may help reduce the destructive inflammation of autoimmune diseases like rheumatoid arthritis, scientists say.They have some of the first evidence of how the cheap, over-the-counter antacid can encourage our spleen to promote instead an anti-inflammatory environment that could be therapeutic in the face of inflammatory disease, Medical College of Georgia scientists report in The Journal of Immunology.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Publication date: Available online 24 April 2018 Source:Canadian Journal of Cardiology Author(s): Yasbanoo Moayedi, Mosaad Alhussein, Juan G. Duero Posada, Stella Kozuszko, Kiran K. Khush, Jeffrey J. Teuteberg, Mitesh V. Badiwala, Heather J. Ross
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Archana Kumari, Om Silakari, Rajesh K. Singh Colony stimulating factor-1 (CSF-1) is one of the most common proinflammatory cytokine responsible for various inflammatory disorders. It has a remarkable role in the development and progression of osteoarthritis, cancer and other autoimmune disease conditions. The CSF-1 acts by binding to the receptor, called colony stimulating factor-1 receptor (CSF-1R) also known as c-FMS resulting in the cascade of signalling pathway causing cell proliferation and differentiation. Interleukin-34 (IL-...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Dr. Giuliano Testa, a transplant surgeon at Baylor University Medical Center at Dallas who led the medical team that performed the first successful uterus transplants in the United States, said Tuesday that he hopes “what we are doing is going to shed light on infertility for women.” “I personally never knew it was such a widespread issue,” Testa said at the TIME 100 Gala on Tuesday. “We should be thinking about it not just as a birth, but a wellbeing issue.” Testa attended the TIME 100 Gala after being named by TIME magazine as one of the most influential people in the world for his rol...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime T1002018 Source Type: news
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