GSE264183 Comparing Gut Microbial Composition and Functional Adaptations between SPF and Non-SPF pigs
This study makes an important contribution to elucidating the impact of environments harboring a variety of microorganisms, including pathogens, on the gut microbiota of miniature pigs. Furthermore, we sought to provide foundational data on the characteristics of the gut microbiota in genetically modified pigs, which serve as source animals for xenotransplantation. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 22, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Sus scrofa Source Type: research
A high-dose of ursodeoxycholic acid treatment alleviates liver inflammation by remodeling gut microbiota and bile acid profile in a mouse model of non-alcoholic steatohepatitis
In conclusion, a high dosage of UDCA can alleviate liver inflammation, probably by modifying the composition of gut microbiota and serum bile acid profiles in NASH mice.PMID:38643542 | DOI:10.1016/j.biopha.2024.116617 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Hu Li Mingjie Wang Peizhan Chen Mingyu Zhu Li Chen Source Type: research
Theabrownin from Qingzhuan tea prevents high-fat diet-induced MASLD via regulating intestinal microbiota
Biomed Pharmacother. 2024 Apr 19;174:116582. doi: 10.1016/j.biopha.2024.116582. Online ahead of print.ABSTRACTThe aim of this study was to investigate whether the therapeutic effect of theabrownin extracted from Qingzhuan tea (QTB) on metabolic dysfunction-associated steatosis liver disease (MASLD) is related to the regulation of intestinal microbiota and its metabolite short-chain fatty acids (SCFAs). Mice were divided into four groups and received normal diet (ND), high-fat diet (HFD) and HFD+QTB (180, 360 mg/kg) for 8 weeks. The results showed that QTB significantly reduced the body weight of HFD mice, ameliorated liver...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 20, 2024 Category: Drugs & Pharmacology Authors: Yong Chen Chen Xie Yining Lei Dan Ye Le Wang Fang Xiong Hui Wu Qiang He Hongfu Zhou Ling Li Jun Xing Cai Wang Min Zheng Source Type: research
The infant gut microbiota as the cornerstone for future gastrointestinal health
Adv Appl Microbiol. 2024;126:93-119. doi: 10.1016/bs.aambs.2024.02.001. Epub 2024 Feb 19.ABSTRACTThe early postnatal period represents a critical window of time for the establishment and maturation of the human gut microbiota. The gut microbiota undergoes dramatic developmental changes during the first year of life, being influenced by a variety of external factors, with diet being a major player. Indeed, the introduction of complementary feeding provides novel nutritive substrates and triggers a shift from milk-adapted gut microbiota toward an adult-like bacterial composition, which is characterized by an enhancement in d...
Source: Advances in Applied Microbiology - April 18, 2024 Category: Microbiology Authors: Chiara Tarracchini Christian Milani Gabriele Andrea Lugli Leonardo Mancabelli Francesca Turroni Douwe van Sinderen Marco Ventura Source Type: research
Next-generation probiotics: the upcoming biotherapeutics
Mol Biol Rep. 2024 Apr 15;51(1):505. doi: 10.1007/s11033-024-09398-5.ABSTRACTRecent and continuing advances in gut microbiome research have pointed out the role of the gut microbiota as an unexplored source of potentially beneficial probiotic microbes. Along the lines of these advances, both public awareness and acceptance of probiotics are increasing. That's why; academic and industrial research is dedicated to identifying and investigating new microbial strains for the development of next-generation probiotics (NGPs). At this time, there is a growing interest in NGPs as biotherapeutics that alter the gut microbiome and a...
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Omnia Momtaz Al-Fakhrany Engy Elekhnawy Source Type: research
Next-generation probiotics: the upcoming biotherapeutics
Mol Biol Rep. 2024 Apr 15;51(1):505. doi: 10.1007/s11033-024-09398-5.ABSTRACTRecent and continuing advances in gut microbiome research have pointed out the role of the gut microbiota as an unexplored source of potentially beneficial probiotic microbes. Along the lines of these advances, both public awareness and acceptance of probiotics are increasing. That's why; academic and industrial research is dedicated to identifying and investigating new microbial strains for the development of next-generation probiotics (NGPs). At this time, there is a growing interest in NGPs as biotherapeutics that alter the gut microbiome and a...
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Omnia Momtaz Al-Fakhrany Engy Elekhnawy Source Type: research
Simultaneously efficient dissolution and structural modification of chrysanthemum pectin: Targeting at proliferation of Bacteroides
This study provided a green strategy for extraction of RG-I enriched prebiotic pectin from plants.PMID:38604432 | DOI:10.1016/j.ijbiomac.2024.131469 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 11, 2024 Category: Biochemistry Authors: Wenying Wang Lianzhu Lin Mouming Zhao Source Type: research
Safflower polysaccharide ameliorates acute ulcerative colitis by regulating STAT3/NF- κB signaling pathways and repairing intestinal barrier function
This study is to investigate the effect of SPS on the UC model. An animal model of UC induced by DSS was developed using C57BL/6 mice. The body weight was recorded every day, and the symptoms related to UC were detected. H&E staining, AB-PAS staining and PSR staining were used to evaluate the histopathological changes of the colon. Inflammation and mucosal barrier indicators were detected by qRT-PCR, and the 16 S rRNA sequence was used to detect the intestinal flora. SPS can significantly prevent and treat DSS-induced ulcerative colitis in animals. SPS significantly improved clinical symptoms, alleviated pathological d...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 9, 2024 Category: Drugs & Pharmacology Authors: Man Qi Shenghui Chu Wenxuan Wang Xianglei Fu Chao Jiang Liang Zhang Md Hasan Ali Yating Lu Mengwei Jia Dilraba Ubul Hui Tang Jian Li Min Liu Source Type: research
Turning weeds into feed: Ensiling Calotropis gigantea (Giant milkweed) reduces its toxicity and enhances its palatability for dairy cows
This study aimed to valorize GM as a potential new feed resource through the chemical and microbial biotransformation of toxic compounds that will henceforth, make the plant palatable for cows. After GM's ensiling using fermentative bacteria, the plant was sampled for UHPLC-MS/MS to analyse the metabolomic changes. Illumina Miseq of the 16 S rRNA fragment genes and ITS1 were used to describe the microbial composition and structure colonizing GM silage and contributing to the biodegradation of toxic compounds. Microbial functions were predicted from metataxonomic data and KEGG pathways analysis. Eight Holstein dairy cows as...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Aurele Gnetegha Ayemele Yuehu Wang Lu Ma Dengpan Bu Jianchu Xu Source Type: research
A universal plasma metabolites-derived signature predicts cardiovascular disease risk in MAFLD
CONCLUSIONS: Simple MAFLD patients and MAFLD patients with CVD risk had divergent gut microbes and plasma metabolites. The predictive model based on metabolites and 9 clinical parameters could effectively discriminate MAFLD patients with CVD risk at a very early stage.PMID:38581738 | DOI:10.1016/j.atherosclerosis.2024.117526 (Source: Atherosclerosis)
Source: Atherosclerosis - April 6, 2024 Category: Cardiology Authors: Zhonglin Li Rui Gong Huikuan Chu Junchao Zeng Can Chen Sanping Xu Lilin Hu Wenkang Gao Li Zhang Hang Yuan Zilu Cheng Cheng Wang Meng Du Qingjing Zhu Li Zhang Lin Rong Xiaoqing Hu Ling Yang Source Type: research
Turning weeds into feed: Ensiling Calotropis gigantea (Giant milkweed) reduces its toxicity and enhances its palatability for dairy cows
This study aimed to valorize GM as a potential new feed resource through the chemical and microbial biotransformation of toxic compounds that will henceforth, make the plant palatable for cows. After GM's ensiling using fermentative bacteria, the plant was sampled for UHPLC-MS/MS to analyse the metabolomic changes. Illumina Miseq of the 16 S rRNA fragment genes and ITS1 were used to describe the microbial composition and structure colonizing GM silage and contributing to the biodegradation of toxic compounds. Microbial functions were predicted from metataxonomic data and KEGG pathways analysis. Eight Holstein dairy cows as...
Source: Cancer Control - April 6, 2024 Category: Cancer & Oncology Authors: Aurele Gnetegha Ayemele Yuehu Wang Lu Ma Dengpan Bu Jianchu Xu Source Type: research
Turning weeds into feed: Ensiling Calotropis gigantea (Giant milkweed) reduces its toxicity and enhances its palatability for dairy cows
This study aimed to valorize GM as a potential new feed resource through the chemical and microbial biotransformation of toxic compounds that will henceforth, make the plant palatable for cows. After GM's ensiling using fermentative bacteria, the plant was sampled for UHPLC-MS/MS to analyse the metabolomic changes. Illumina Miseq of the 16 S rRNA fragment genes and ITS1 were used to describe the microbial composition and structure colonizing GM silage and contributing to the biodegradation of toxic compounds. Microbial functions were predicted from metataxonomic data and KEGG pathways analysis. Eight Holstein dairy cows as...
Source: Ecotoxicology and Environmental Safety - April 6, 2024 Category: Environmental Health Authors: Aurele Gnetegha Ayemele Yuehu Wang Lu Ma Dengpan Bu Jianchu Xu Source Type: research
Protective effect of cellulose and soluble dietary fiber from Saccharina japonica by-products on regulating inflammatory responses, gut microbiota, and SCFAs production in colitis mice
This study aimed to investigate the physicochemical properties of soluble dietary fiber (SDF) and cellulose enriched in Saccharina japonica by-products and to evaluate their anti-colitis effects. The water-holding capacity (WHC), swelling capacity (SC), cation exchange capacity (CEC), and antioxidant properties of SDF were superior to cellulose. The ΔH of SDF and cellulose was 340.73 J/g and 134.56 J/g, and the average particle size of them was 43.858 μm and 97.350 μm. The viscosity of SDF was positively correlated with the content. SEM revealed that the microstructure of SDF was porous, whereas cellulose was folded. SD...
Source: International Journal of Biological Macromolecules - April 5, 2024 Category: Biochemistry Authors: Junhan Cao Ling Qin Liping Zhang Kai Wang Mengke Yao Changfeng Qu Jinlai Miao Source Type: research
Effects of dietary selenized glucose on intestinal microbiota and tryptophan metabolism in rats: Assessing skatole reduction potential
In this study, a diverse range of dietary SeGlu-treated levels, including SeGlu-deficient (CK), SeGlu-adequate (0.15 mg Se per L), and SeGlu-supranutritional (0.4 mg Se per L) conditions, were used to investigate the complex interaction of SeGlu on intestinal microbiome and serum metabolome changes in male Sprague-Dawley (SD) rats. The study showed that SeGlu supplementation enhanced the antioxidant ability in rats, significantly manifested in the increases of the activity of catalase (CAT) and glutathione peroxidase (GSH-Px), while no change in the level of malonaldehyde (MDA). Metagenomic sequencing analysis verified tha...
Source: Environmental Research - April 5, 2024 Category: Environmental Health Authors: Zhi Zeng Bo Lv Yun-E Tang Huimin Sun Shunfeng Li Yuan He Juan Wang Zhi Wang Source Type: research
Protective effect of cellulose and soluble dietary fiber from Saccharina japonica by-products on regulating inflammatory responses, gut microbiota, and SCFAs production in colitis mice
This study aimed to investigate the physicochemical properties of soluble dietary fiber (SDF) and cellulose enriched in Saccharina japonica by-products and to evaluate their anti-colitis effects. The water-holding capacity (WHC), swelling capacity (SC), cation exchange capacity (CEC), and antioxidant properties of SDF were superior to cellulose. The ΔH of SDF and cellulose was 340.73 J/g and 134.56 J/g, and the average particle size of them was 43.858 μm and 97.350 μm. The viscosity of SDF was positively correlated with the content. SEM revealed that the microstructure of SDF was porous, whereas cellulose was folded. SD...
Source: International Journal of Biological Macromolecules - April 5, 2024 Category: Biochemistry Authors: Junhan Cao Ling Qin Liping Zhang Kai Wang Mengke Yao Changfeng Qu Jinlai Miao Source Type: research
