Fight Aging! Newsletter, March 11th 2019

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is published under the Creative Commons Attribution 4.0 International License. You are encouraged to republish and rewrite it in any way you see fit, the only requirements being that you provide attribution and a link to Fight Aging! To subscribe or unsubscribe please visit: https://www.fightaging.org/newsletter/ Contents Video of Investor Jim Mellon Presenting at Abundance 360 Summit 2019 Apollo Ventures Funds Autophagy Enhancement Startup Samsara Therapeutics RAGE Knockout Reduces Age-Related Kidney Damage in Mice The Significance of Senescent Astrocytes in the Aging Brain Insulin and IGF-1 in Human Aging and Longevity Control of Inflammation May Contribute to the Longevity of Bats Frailty Dramatically Increases Mortality Risk at any Age Targeted Delivery of GDNF to Areas of the Brain Improves Parkinson's Symptoms An Outl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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MRC Laboratory of Molecular Biology researchers reveal atomic structures of the abnormal tau filaments associated with chronic traumatic encephalopathy, a head injury-associated neurodegenerative disease, differ in structure from those seen in Alzheimer’s disease.
Source: Medical Research Council General News - Category: Research Source Type: news
ConclusionsThese findings indicate that the neural effects of AUD vary according to severity. Our results emphasize the utility of resting state fMRI as a neuroimaging biomarker for quantitative clinical evaluation of AUD.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 19 March 2019Source: NeuroImage: ClinicalAuthor(s): Jason A. Martin, Nadine Zimmermann, Lukas Scheef, Jakob Jankowski, Sebastian Paus, Hans H. Schild, Thomas Klockgether, Henning BoeckerAbstractMany studies have used functional magnetic resonance imaging to unravel the neuronal underpinnings of motor system abnormalities in Parkinson's disease, indicating functional inhibition at the level of basal ganglia-thalamo-cortical motor networks. The study aim was to extend the characterization of functional motor changes in Parkinson's Disease by dissociating between two phases of action (i.e. m...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
ConclusionsA clinically relevant model of PTA of venous stenosis in mice was created. PTA-treated vessels had increased lumen vessel area and WSS. The alterations in tissue markers of vascular remodeling, tissue hypoxia, proliferation, and cell death may be implications for future design of drug and device development.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: Available online 20 March 2019Source: The Social Science JournalAuthor(s): J.M. Faílde Garrido, M.D. Dapía Conde, M.A. Vázquez Vázquez, L. Ruíz Soriano, L. Vázquez RodríguezAbstractThe increase in longevity and population aging are the greatest conquest and social challenge that we face in this century, especially in the most developed countries. Spain is, currently, one of the oldest countries in the European Union and it is expected that in 2050 it will be the oldest country in the world, second only to Japan, with the region of Galicia (located in the no...
Source: The Social Science Journal - Category: Psychiatry & Psychology Source Type: research
Psychother Psychosom
Source: Psychotherapy and Psychosomatics - Category: Psychiatry & Psychology Source Type: research
ConclusionsFOSL1 is an independent prognostic biomarker of GC. Detecting FOSL1 expression could help stratify GC patients with high-risk and guide the precious treatment.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
In this study, we aimed to investigate the role of IL-6/Stat3 signaling pathway in human endometrial cancer cells invasion and migration. We demonstrated that Stat3 is activated in endometrial cancer cell lines. To investigate the role of Stat3 in endometrial cancer invasive capacity, we used Stat3 inhibitor Stattic and found that Stattic significantly inhibited the migration and invasion of endometrial cancer cells elevated by IL-6. Furthermore, we showed that Stat3 inhibitor significantly decreased the expression of MMP2 enhanced by IL-6, indicating that IL-6 promoted endometrial cancer invasion and migration by Stat3-in...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 19 March 2019Source: Pathology - Research and PracticeAuthor(s): Xiaobo He, Ying ShuAbstractIncreasing evidence has shown that dysregulation of mircoRNA (miRNA) is linked to the development and progression of human cancer, including gastric cancer (GC). In the current study, by analysing the GEO database (GSE78091), we found that miR-660 was significantly downregulated in GC. Consistently, quantitative real-time PCR (qRT-PCR) results showed that miR-660 was dramatically decreased in GC tissues and cell lines. Importantly, low miR-660 expression was closely related to larger tumor size (P&...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionsThe results pointed out that the high expression of miR-106b-5p serves as an independent factor for predicting the worse prognosis of RCC patients.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
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