Fight Aging! Newsletter, March 11th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is published under the Creative Commons Attribution 4.0 International License. You are encouraged to republish and rewrite it in any way you see fit, the only requirements being that you provide attribution and a link to Fight Aging! To subscribe or unsubscribe please visit: https://www.fightaging.org/newsletter/ Contents Video of Investor Jim Mellon Presenting at Abundance 360 Summit 2019 Apollo Ventures Funds Autophagy Enhancement Startup Samsara Therapeutics RAGE Knockout Reduces Age-Related Kidney Damage in Mice The Significance of Senescent Astrocytes in the Aging Brain Insulin and IGF-1 in Human Aging and Longevity Control of Inflammation May Contribute to the Longevity of Bats Frailty Dramatically Increases Mortality Risk at any Age Targeted Delivery of GDNF to Areas of the Brain Improves Parkinson's Symptoms An Outl...
Publication date: Available online 30 May 2020Source: Life SciencesAuthor(s): Qi Fu, Zhenhai Yu
Publication date: Available online 30 May 2020Source: Life SciencesAuthor(s): Lakshmikripa Jagannathan, Emily Socks, Priya Balasubramanian, Robert McGowan, Thomas M. Herdt, Reza Kianian, Sheba M.J. MohanKumar, P.S. MohanKumar
Publication date: Available online 29 May 2020Source: Life SciencesAuthor(s): Nagesh Kishan Panchal, E.P. Sabina
This study revealed the association between PAH exposure and markers of inflammation and oxidative stress, and the enhanced responses of pre-T2D patients suggested that individuals with metabolic disorders were more susceptible to the adverse health effects of PAH exposure. PMID: 32464779 [PubMed - in process]
In this study, five machine learning algorithms and twelve types of molecular fingerprints were employed to generate QSAR discriminant models for mitochondrial toxicity. A threshold moving method was adopted to resolve the imbalance issue in the training data. Consensus of the models by an averaging probability strategy improved prediction performance. The best model has correct classification rates of 81.8% and 88.3% in ten-fold cross validation and external validation, respectively. Substructures such as phenol, carboxylic acid, nitro and arylchloride were found informative through analysis of information gain and freque...
Abstract Zeranol is an approved but controversial growth-promoting agent for livestock in North America. It is a mycotoxin metabolite secreted by the Fusarium family fungi. The regulatory bodies in this region have established the acceptable daily intake and exposure below the level would not significantly increase the health risk for humans. However, their European counterparts have yet to establish an acceptable level and do not permit the use of this agent in farm animals. Given the growth-promoting ability of zeranol, its effect on energy metabolism was investigated in the current study. Our results indicated ...
Publication date: 30 May 2020Source: New Scientist, Volume 246, Issue 3284Author(s): Adam Vaughan
Publication date: 30 May 2020Source: New Scientist, Volume 246, Issue 3284Author(s): Alice Klein
Donald Trump and Mike Pence witness launch in FloridaFirst attempt was cancelled minutes from blast-offA rocketship named Dragon breathed new fire into America ’s human spaceflight programme on Saturday, carrying two astronauts on a much-anticipated adventure.Related:Trump wants America looking at the stars as he drags it through the gutterContinue reading...
Publication date: Available online 30 March 2020Source: Journal of Genetics and GenomicsAuthor(s): Gang Liu, Haijuan Xiao, Linlin Liu, Lingyun Guo, Ruolan Guo, Xuyun Hu, Chanjuan Hao, Jingang Gui, Weiwei Jiao, Fang Xu, Adong Shen, Wei Li
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