Fight Aging! Newsletter, October 15th 2018

This study suggests that exocrine glands can be induced from pluripotent stem cells for organ replacement regenerative therapy. Replacement of Aged Microglia Partially Reverses Cognitive Decline in Mice https://www.fightaging.org/archives/2018/10/replacement-of-aged-microglia-partially-reverses-cognitive-decline-in-mice/ Researchers here report on a compelling demonstration that shows the degree to which dysfunctional microglia contribute to age-related neurodegeneration. The scientists use a pharmacological approach to greatly deplete the microglial population and then allow it to recover naturally. The influx of new microglia improves many aspects of brain function, though interestingly this procedure doesn't appear to affect the inflammatory status of brain tissue. Most neurodegenerative conditions are thought to be driven to some degree by inflammation, while the data here suggests that the activities of glial cells that support neuronal function are not to be neglected. The data also suggests that inflammation is a reaction to the state of brain tissue, rather than something that arises from intrinsic issues within glial cells. That conclusion is contradicted by other recent research in which senescent glial cells are shown to definitively contribute to the pathology of neurodegenerative disease. Perhaps the resolution of this contradiction is that senescent glial cells are resistant to depletion via the methodology used here, but that is pure s...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: Available online 15 July 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Emad I. Wafa, Sean M. Geary, Kathleen A. Ross, Jonathan T. Goodman, Balaji Narasimhan, Aliasger K. SalemAbstractThe primary objective of this study was to enhance the antitumor efficacy of a model cancer vaccine through co-delivery of pentaerythritol lipid A (PELA), an immunological adjuvant, and a model tumor antigen, ovalbumin (OVA), separately loaded into polyanhydride particles (PA). In vitro experiments showed that encapsulation of PELA into PA (PA-PELA) significantly enhanced its stimulatory capacity on...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
The identification of mutations in the amyloid precursor protein (APP) and PSEN1 and PSEN2 that cause autosomal dominantly inherited Alzheimer ’s disease (AD) and result in increased production of aggregation-prone forms of amyloid-β (Aβ) established beyond a doubt that APP processing and the production of Aβ peptides are intimately involved in the disease process and led to the proposal of and support for the amyloid cascade hypothes is for AD (1,2). Despite its strengths, the amyloid cascade hypothesis is incomplete without addressing the essential role of amyloid-associated proteins [for reviews, see (3,4)].
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Alzheimer ’s disease (AD) is characterized by the hallmark pathologies of amyloid-β (Aβ) plaques and tau tangles. Recently, many drug trials and much research have focused on preventing or removing these pathologies, especially Aβ. While some trials have been able to effect change in amyloid levels, none have succeeded in improving cognition. Although the trials may have involved patients that were too advanced for benefit with antiamyloid therapies, an inability of these drugs to protect synaptic function may have contributed to their failure.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
With the advances of modern medicine, people are living longer than ever before worldwide. Consequently, an increase in patients with dementia has become a serious social concern, with Alzheimer ’s disease (AD) being the most common form of dementia. In 2015, the World Alzheimer Report estimated that approximately 46.8 million people had AD and other types of dementia worldwide. Accordingly, the number of such patients is predicted to increase to more than 131.5 million by the year 2050. Therefore, the development of new therapeutic alternatives to control AD progression and even reverse the disease is urgently needed.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Adhering to a healthy lifestyle reduces the chances of developing dementia, even among those at genetic risk for dementia, new research suggests.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Psychiatry News Source Type: news
Publication date: Available online 15 July 2019Source: Innovative Food Science &Emerging TechnologiesAuthor(s): T.E. ArunaAbstractPineapple (Ananas comosus) peels are agricultural plant residues that contribute to waste disposal problem and there is little information on their conversion to useful products. Solid state fermentation (SSF) of pineapple peels (with and without ammonium sulphate) was done with a view to increase their protein content using Trichoderma viride ATCC 36316 for 96 h at 30 °C. The study was carried out using conical flasks and on-farm solid state fermenter. Chemical composition (fat, cru...
Source: Innovative Food Science and Emerging Technologies - Category: Food Science Source Type: research
Multisensory impairment may serve as a potential marker to help identify older adults at increased risk of developing dementia or Alzheimer disease.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Neurology & Neurosurgery News Source Type: news
Authors: Kruthiventi SC, Kane GC, Sprung J, Weingarten TN, Warner ME Abstract Patients with pulmonary hypertension are at increased risk for postoperative pulmonary complications (PPCs). Herein, we review PPCs in pulmonary hypertension patients undergoing non-cardiac procedures under general anesthesia. The medical records of pulmonary hypertension patients who underwent surgery with general anesthesia between 2010 and 2017 were reviewed for PPCs. In addition we reviewed nursing-documented respiratory depressive episodes in the post-anesthesia care unit to assess the associations between these episodes and later PP...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
We report a clinical case of DRESS syndrome with liver injury, evaluated with the RegiSCAR scoring system as a "definite case" possibly induced by carbamazepine in a patient. PMID: 31299851 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Sarkar R, Paul R, Thakur I, Ghosh R, Singh S, Mani A, Sau TJ, Lahiri G Abstract Dengue virus induced encephalitis is a very rare entity and its full clinicoradiological profile is still unknown. We here report two cases of dengue encephalitis from Eastern India. The first one is a 20 year old female and the second one is a 13 year old boy. Both of them presented with altered consciousness and seizures. Blood and CSF study for dengue IgM were positive. MRI of brain showed T2 hyperintensity in the Thalami along with similar changes in other parts of the brain. Both patients responded to conservative therapy ...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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