Fight Aging! Newsletter, June 11th 2018

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is published under the Creative Commons Attribution 4.0 International License. You are encouraged to republish and rewrite it in any way you see fit, the only requirements being that you provide attribution and a link to Fight Aging! To subscribe or unsubscribe please visit: https://www.fightaging.org/newsletter/ Contents Oisin Biotechnologies CSO John Lewis at Undoing Aging Can a Reasonable Argument be Made for Variations in Human Longevity to be Significantly Driven by DNA Repair? A Recent Profile of Unity Biotechnology and its Work on Senolytic Therapies Antibodies Targeting Oxidized Lipids Slow the Development of Atherosclerosis A Selection of Recent Research in the Alzheimer's Field An Interview with Jim Mellon, and Update on Juvenescence Why is Alzheimer's Disease Peculiarly Human? Arguing for Nicotinamide Riboside to I...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
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Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
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Source: Archives of Physiology and Biochemistry - Category: Physiology Authors: Source Type: research
Publication date: 15 March 2020Source: Journal of Molecular Liquids, Volume 302Author(s): Ângela Sousa, Rúben Faria, Tânia Albuquerque, Himanshu Bhatt, Swati Biswas, João A. Queiroz, Diana CostaAbstractMitochondrial gene therapy can be seen as a promising tool and a revolutionary approach towards mitochondrial diseases arising from mitochondrial DNA mutations. The conception of a viable and suitable mitochondrial targeted vector is imperative to turn this therapy clinically feasible. To accomplish this goal, different molecular weight polyethylenimines (PEI) have been conjugated with the mitochond...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 24 January 2020Source: Plant ScienceAuthor(s): Hongyan Lu, Zisheng Luo, Lei Wang, Wusheng Liu, Dong Li, Tarun Belwal, Yanqun Xu, Li LiAbstractThe large-scale untargeted proteomic and metabolomic studies were conducted in strawberry (Fragaria × ananassa) cv. Akihime fruit at five developmental stages. We found that some C6 volatiles highly contributed to the enrichment of volatiles at the red stage of strawberry fruit. We found that 12 genes involved in LOX pathway for volatile biosynthesis showed multiple patterns in protein abundance during fruit development and ripen...
Source: Plant Science - Category: Biology Source Type: research
In this study, we cloned the sole soybean homolog of OsGPA3 that encodes a plant-unique kelch-repeat regulator of post-Golgi vesicular traffic for rice storage protein sorting. A complementation test showed that GmGPA3 could rescue the rice gpa3 mutant. Biochemical assays verified that GmGPA3 physically interacts with GmRab5 and its guanine exchange factor (GEF) GmVPS9. Expression of GmGPA3 had no obvious effect on the GEF activity of GmVPS9 toward GmRab5a. Notably, knock-down of GmGPA3 disrupted the trafficking of mmRFP-CT10 (an artificial cargo destined for PSVs) in developing soybean cotyledons. We identified two putati...
Source: Plant Science - Category: Biology Source Type: research
Publication date: Available online 24 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Tingbei Bo, Jing Wen, Yuanchun Zhao, Shuangjie Tian, Xueying Zhang, Dehua WangAbstractObesity has become a growing concern around the world. The purpose of this study was to investigate the potential benefit of Bifidobacterium pseudolongum (B. pseudolongum) on obesity, gut microbiota, and its physiological mechanism. The obese mice model was established with a high-fat diet (HFD), and the treatment were used the strain B. pseudolongum. We investigated the changes in fat content, plasma metabolites a...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Authors: Fabbre VD, Gaveras E Abstract Transgender and gender nonconforming (TGNC) people experience disparities in mental health when compared with non-TGNC sexual minorities and the general population. One line of inquiry with respect to these disparities is the examination of stigma and its connection to emotional and psychological well-being. Recent conceptualizations of stigma draw attention to multiple levels-individual, interpersonal, and structural-that are thought to impact well-being for TGNC people. However, little is known about how multilevel stigma is experienced by TGNC older adults, who navigate sti...
Source: The American Journal of Orthopsychiatry - Category: Psychiatry Tags: Am J Orthopsychiatry Source Type: research
CONCLUSIONS: Although our findings were inconclusive, the earlier age of onset observed among neurodegenerative disease patients carrying the CCR5-delta32 allele suggests that the deletion may have a detrimental effect in the context of neurodegeneration. PMID: 31972607 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Authors: Ye X, Gray E, Wang YF, Wang SJ Abstract Objectives: To assess the cost-effectiveness of mirogabalin versus no treatment or pregabalin in patients with post-herpetic neuralgia (PHN) from a third-party perspective in Taiwan.Methods: A Markov model, which was developed with 2-week cycles and 1-year time horizon from the Taiwanese National Health Insurance Administration perspective, consisted of three health states: 'mild', 'moderate' and 'severe' pain. Average daily pain score (ADPS) was assessed at the end of each cycle. Patients either remained in, or transitioned from, their assigned health state to a dif...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
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