Fight Aging! Newsletter, March 26th 2018

In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currently ongoing. Survivors of hematopoietic stem cell transplantation are prone to premature aging, and one pilot clinical study is designed to test whether dasatinib and quercetin (D + Q) can suppress aging in these patients (NCT02652052). Another clinical trial is testing whether D + Q reduces pro-inflammatory cells obtained by skin biopsy in patients with idiopathic pulmonary fibrosis (NCT02874989). Furthermore, a clinical trial is ongoing to determine whether D + Q can reduce the senescent cell burden and frailty in patients with chronic kidney disease, as well as improving the function of adipose tissue-derived mesenchymal stem cells (NCT02848131). So far, only D + Q has been assessed in the clinical setting, and none of the current clinical trials are testing whether senolytic agents can inhibit cardiovascular disorders. However, depletion of senescen...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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This study aimed to assess the relative safety and short-term efficacy of drug-eluting bead transarterial chemoembolization (DEB-TACE) and conventional transarterial chemoembolization (c-TACE) for treating peculiar anatomical sites of gastric cancer liver metastasis. MATERIAL AND METHODS Of the 68 patients with gastric cancer liver metastases confirmed by imaging and pathology, 35 were treated with DEB-TACE and 33 with c-TACE. The DEB-TACE group comprised 26 males and 9 females aged 28-75 years (56.8±6.3), and the c-TACE group included 19 males and 14 females aged 33-77 (60.2±9.4) years. Liver functions of th...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS The network pharmacology analysis reveals the molecular biological mechanism of Artemisia annua anti-NSCLC via multiple active components, multi-channels, and multi-targets. This suggests that Artemisia annua might be developed as a promising anti-NSCLC drug. PMID: 32474568 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ01814G, PaperGurpreet Kaur, Monika Chaudhary, Kailash C Jena, Narinder Singh Abstract Environmental contamination due to increase in drug level is touching its alarming stage. There is an array of drugs such as antibiotics, antidepressants, analgesics, cancer chemotherapy drugs etc which... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Analyst, 2020, Advance Article DOI: 10.1039/D0AN00627K, PaperJun Liu, Cheng Cao We propose a novel GSH-generating prodrug to be used with a sulfonamide-induced “integrative” platform for selective cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Hi everyone! I’m looking for advice on which schools to apply to in this cycle. I qualify as Disadvantaged on AMCAS and have FAP so I am able to apply to 20 schools. I’ve left off the Philly schools for personal reasons but am open to any other suggestions for my school list. cGPA: 3.7, sGPA: 3.6 For additional context, I had a really rough first 3 semesters of undergrad which included loss of income for my family, a parent’s cancer diagnosis, and 2 hospitalizations for... WAMC/School List: 3.7 cGPA/3.6 sGPA/515 MCAT
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: What Are My Chances? WAMC Medical Source Type: forums
Publication date: Available online 31 May 2020Source: European Journal of RadiologyAuthor(s): Qi Zhang, Han Ouyang, Feng Ye, Shuang Chen, Lizhi Xie, Xinming Zhao, Xiaoduo Yu
Source: European Journal of Radiology - Category: Radiology Source Type: research
Publication date: Available online 31 May 2020Source: Mental Health and Physical ActivityAuthor(s): J.E. King, H. Jebeile, S.P. Garnett, L.A. Baur, S.J. Paxton, M.L. Gow
Source: Mental Health and Physical Activity - Category: Psychiatry & Psychology Source Type: research
Resumo Neste texto, amparados pelos conceitos de Deleuze e utilizando-nos do m étodo cartográfico, que consiste no acompanhamento de processos de uma realidade, objetivamos compartilhar um momento de nossa pesquisa-intervenção centrada na produção estética dos corpos em escolas, realizada em escola municipal de EJA. Focar-nos-emos no acompanhamento do caso de uma estuda nte, a qual angustiava aos educadores por ser entendida como sujeito de educação especial e vítima de abuso sexual. Lançando mão da noção deleuzeana de é...
Source: Psicologia e Sociedade - Category: Psychiatry & Psychology Source Type: research
This article focuses on discussing fatalism in peasant labor and its possibilities of rupture. It is based on the theoretical contributions of Ignacio Mart ín-Baró and takes as an empirical reference the reports of peasants from the Center-South region of the State of Paraná, Brazil. The reports were obtained through a conversation circle with agroecologist farmers and semi-structured interviews with five tobacco-producing families. Taking tobacco p roduction and the diversification of this production for agroecological agriculture as an example, this work seeks to highlight labor relations as a source...
Source: Psicologia e Sociedade - Category: Psychiatry & Psychology Source Type: research
This article is built on reflections based on a Brazilian psychoanalysis with an interface in social psychology, aiming to integrate it into the Mozambican Mental Health. Mozambique is a country that operates in a non-westernized logic; with a care system that for centuries has come from healing practices, known in the country as Traditional Medicine. As public mental health policies are governed by a Western perspective, a question was raised about the theoretical reformulations that might be necessary for the insertion of new clinical devices in the country, including traditional knowledge. Being a traverse, the method o...
Source: Psicologia e Sociedade - Category: Psychiatry & Psychology Source Type: research
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