Fight Aging! Newsletter, March 26th 2018

In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currently ongoing. Survivors of hematopoietic stem cell transplantation are prone to premature aging, and one pilot clinical study is designed to test whether dasatinib and quercetin (D + Q) can suppress aging in these patients (NCT02652052). Another clinical trial is testing whether D + Q reduces pro-inflammatory cells obtained by skin biopsy in patients with idiopathic pulmonary fibrosis (NCT02874989). Furthermore, a clinical trial is ongoing to determine whether D + Q can reduce the senescent cell burden and frailty in patients with chronic kidney disease, as well as improving the function of adipose tissue-derived mesenchymal stem cells (NCT02848131). So far, only D + Q has been assessed in the clinical setting, and none of the current clinical trials are testing whether senolytic agents can inhibit cardiovascular disorders. However, depletion of senescen...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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ACP Journals Effectiveness and Safety of Direct Oral Anticoagulants Versus Warfarin in Patients With Valvular Atrial Fibrillation So we can use DOACs now for valvular Afib (See study above), we've been using DOACs for other VTEs, and recently shown to be safe in even cancer-related VTEs. Is there any reason (maybe poor renal function) to continue using warfarin?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Internal Medicine and IM Subspecialties Source Type: forums
We report a rare distal insertional site not previously documented. A 50-year-old man presented with anterior knee pain. MRI showed an accessory band deep to the ITB, partially blending in with its superficial fibres. It inserted onto the anterolateral tibia l tuberosity, deep to the patellar tendon insertion and inferomedial to Gerdy’s tubercle. This was asymptomatic but the patient did have an underlying median patella ridge osteochondral defect successfully treated with stem cell grafting, completely unrelated to the mentioned variant. This case hi ghlights the importance of detecting rare anatomical variants whic...
Source: Skeletal Radiology - Category: Radiology Source Type: research
AbstractObjectiveTo determine whether skip metastases (SM) in high-grade appendicular osteosarcoma (HG-OS) are an indicator of more aggressive disease.Materials and methodRetrospective review of patients with histologically confirmed diagnosis HG-OS of the long bones from 2007 to 2020, who had whole-bone MRI to identify SM. Data collected included patient age/gender, bone involved, the presence of SM, the presence of lung metastases from chest CT, the presence of distant bone metastases from whole-body bone scintigraphy or whole-body MRI, and chemotherapy response from resection specimen histology. The presence of lung or ...
Source: Skeletal Radiology - Category: Radiology Source Type: research
ConclusionsThese findings indicate that trait mindfulness facets may not independently affect BP and HR responses to acute emotional stress among prehypertensive but otherwise healthy adults with normal stress levels, prior to mindfulness training. Mindfulness-based interventions may therefore be necessary to engender benefits of mindfulness on stress physiology, as a putative biological mechanism of cardiovascular risk reduction and health promotion.Trial registration number and date of registration: NCT02371317, 1/21/2015
Source: Mindfulness - Category: Psychiatry & Psychology Source Type: research
The objective of this study was to examine the current state of literature on group prenatal care and its impact on maternal outcomes and racial disparities in adverse maternal outcomes. Design: We conducted a scoping review of literature published between January 2010 and December 2020 using the PRISMA-ScR reporting checklist. Methods: Eligible studies were identified using key words and MeSH terms in PubMed, CINAHL, and Web of Science. Inclusion criteria were studies that were (a) conducted in the United States; (b) published between January 2010 and December 2020; (c) in English; (d) focused on the primary...
Source: MCN: The American Journal of Maternal Child Nursing - Category: Nursing Tags: Feature Source Type: research
Background: Feeding difficulty is the most common cause of delayed hospital discharge and readmission of late preterm infants. Frequent and adequate feedings from birth are protective against dehydration, hypoglycemia, and jaundice. The National Perinatal Association's feeding guidelines provide the foundation for late preterm infant standards of care. Feeding at least every 3 hours promotes nutritional status and neurologic development. One feeding assessment every 12 hours during the hospital stay can ensure quality of infant feeding. Problem: At a large urban hospital, medical record reviews were completed to...
Source: MCN: The American Journal of Maternal Child Nursing - Category: Nursing Tags: Feature: NCPD Connection Source Type: research
No abstract available
Source: MCN: The American Journal of Maternal Child Nursing - Category: Nursing Tags: ONGOING COLUMNS: Hot Topics in Maternity Nursing Source Type: research
THE UK is facing the "biggest cancer crisis in living memory" and the Government claims that the country is on track to meet targets that could worsen the crisis, Parliament will hear next week.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
No abstract available
Source: Biomedical Safety and Standards - Category: Medical Devices Tags: RECALLS & FIELD CORRECTIONS—CLASS II Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
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