A diagnosis you can ’t afford to miss
4 out of 5 stars Antibody-Mediated Encephalitis. Dalmau J, Graus F. N Engl J Med 2018 Mar 1;378:840-851. Reference TPR has posted before about anti-NMDA receptor encephalitis, a must-know, can’t-miss, humbling diagnosis that is distressingly easy to overlook. Although it is not a toxicologic condition, all toxicologists and emergency physicians should be thoroughly familiar with its presentation and clinical course. Let me explain why. NMDAR encephalitis often begins with behavioral changes, mood swings, and memory deficits in relatively young patients. According to this somewhat technical but excellent review, ...
Source: The Poison Review - March 2, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical anbitody-mediated encephalitis anti-NMDA receptor encephalitis brain on fire diagnosis Source Type: news
UCLA scientists use stem cells to study genetics of germ cell tumors
UCLA researchers have made new inroads into understanding germ cell tumors, a diverse and rare group of cancers that begin in germ cells — the cells that develop into sperm and eggs. The researchers developed a protocol to recreate germ cell tumor cells from stem cells and used the new model to study the genetics of the cancer.Their findings could point the way toward new drugs to treat germ cell tumors, which account for around 3 percent of all cases of childhood and adolescent cancer.The study, published in Stem Cell Research, was led by Amander Clark, a UCLA professor of molecular cell and developmental biology an...
Source: UCLA Newsroom: Health Sciences - January 29, 2018 Category: Universities & Medical Training Source Type: news
Solving the mystery of a shapeshifting neck tumor
Jaedin, 10 years old, holds the control for a remote-controlled race car, Christmas 2017. Amanda Brown couldn’t shake an uneasy intuition that something just seemed “off” throughout her second pregnancy. During a scheduled caesarian section at her local hospital in North Carolina, her instinct proved to be true. “I had given birth to my first son by C-section so I knew what to expect,” Amanda says. “But this time around, as the surgeons totally stalled in the middle of the delivery, I thought to myself, ‘it doesn’t take this long to pull a baby out.’” When her son...
Source: Thrive, Children's Hospital Boston - January 24, 2018 Category: Pediatrics Authors: Kat J. McAlpine Tags: Diseases & Conditions Our Patients’ Stories Center for Airway Disorders cervical teratoma Dr. Reza Rahbar germ cell tumor Neck and Skullbase Surgery Program at Boston Children's NICU Solid Tumors Center at Dana-Farber/Boston Children's Source Type: news
Football sized tumor on women's ovary causes memory-loss
Kira Hartley, 27, from Illinois, was diagnosed with a massive tumor identified as a teratoma on one of her ovaries that caused seizures, hallucinations and memory loss. (Source: the Mail online | Health)
Source: the Mail online | Health - November 9, 2017 Category: Consumer Health News Source Type: news
Traumatic rupture of a posterior mediastinal teratoma following motor-vehicle accident - Bell C, Domingo F, Miller AD, Smith JS, Headrick JR.
We report a case of a posterior mediastinal mature cystic teratoma with rupture secondary to blunt chest trauma in a 20-year-old male involved in a motor-vehicle accident. Initial treatment was guided by Advanced Trauma Life Support and a tube thoracostomy... (Source: SafetyLit)
Source: SafetyLit - November 9, 2016 Category: Global & Universal Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Scientists illuminate a method for safer stem cell treatments
(American Chemical Society) Because they can develop, or differentiate, into basically any tissue type, pluripotent stem cells could be the key to a host of regeneration therapies. But those PSCs in a culture dish that remain undifferentiated could form teratomas, a kind of tumor, if transplanted into patients. This week in ACS Central Science, researchers report a new light-based technology that could remove this risk. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 3, 2016 Category: Global & Universal Source Type: news
Surrey teenager who thought cramps were food allergy discovers she has rare tumour
Kezia Denne, 16, from Elstead, Surrey, was rushed to hospital complaining of stomach pains. Doctors tested her and said she had a germ cell tumour - immature teratoma - in her ovary. (Source: the Mail online | Health)
Source: the Mail online | Health - September 28, 2016 Category: Consumer Health News Source Type: news
Uterine Myometrial Teratoma Presenting As a Uterine MassUterine Myometrial Teratoma Presenting As a Uterine Mass
What was the unusual origin of this patient's uterine mass? BMC Clinical Pathology (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - April 26, 2016 Category: Pathology Tags: Ob/Gyn & Women ' s Health Journal Article Source Type: news
What is Immature Tertatoma and How is it Treated?
What kind of malignant germ cell tumor are immature teratomas, how are they treated and how is prognosis determined? (Source: About.com Ovarian Cancer)
Source: About.com Ovarian Cancer - February 23, 2016 Category: Cancer & Oncology Authors: ovariancancer.guide at about.com Tags: health Source Type: news
Mountain Lion Found With Teeth Growing Out Of Its Head
A hunter tracking an aggressive mountain lion made a startling discovery when the cat's body turned up with an extra set of teeth on top of its head, wildlife officials said. A photo of the deformed male juvenile, bagged outside Preston, Idaho, was released Thursday by the state’s Fish and Game department. "The mountain lion had an unusual deformity -- fully-formed teeth and what appears to be small whiskers were growing out of hard fur-covered tissue on the left side of the animal's forehead,” the department said in a release Friday. "Idaho Fish and Game cannot definitively explai...
Source: Science - The Huffington Post - January 10, 2016 Category: Science Source Type: news
Mason’s story: A newborn with a peach-sized tumor
When Tara Johnson found out— after 10 years of trying to get pregnant—she was carrying boy-girl twins, she was thrilled. “It was so exciting, it felt like a double blessing,” she remembers. The pregnancy progressed normally until her 21-week checkup when everything changed. Doctors found a large growth on the neck of her unborn son. Tara’s care was transferred to Brigham and Women’s Hospital, and doctors from Endocrinology and Otolaryngology at Boston Children’s Hospital formed a team to manage her son’s care. When she was 31 weeks pregnant, Tara and husband Bruce were in Bos...
Source: Thrive, Children's Hospital Boston - August 26, 2015 Category: Pediatrics Authors: Jenny Fernandez Tags: All posts Our patients’ stories Department of Otolaryngology and Communication Enhancement Dr. C. Jason Smithers Dr. Reza Rahbar tumor Source Type: news
Early Detection of Ovarian Cancer
Thankfully, none of the women in my family have had ovarian cancer. However, when my mother was in her late 30s, she saw a gynecologist after she developed a sudden, sharp pain in her side and missed her period. He examined her and ran some blood tests. Initially, they thought she might be pregnant or even have an ectopic pregnancy because the blood test revealed an elevated level of the "pregnancy hormone" HCG (Human Chorionic Gonadotropin). But pregnancy was not the diagnosis. An ultrasound revealed that my mother had a benign growth on one of her ovaries called a teratoma. Surgery was immediately performed and...
Source: Healthy Living - The Huffington Post - July 29, 2015 Category: Consumer Health News Source Type: news
Maidstone woman who doctors believed was pregnant had cancerous tumour
Louise Bryant, 26, of Maidstone, had an immature teratoma, a rare type of ovarian cancer. She underwent a four hour operation to remove the 20cm growth and her fallopian tube. (Source: the Mail online | Health)
Source: the Mail online | Health - July 20, 2015 Category: Consumer Health News Source Type: news
A mother’s intuition—and a fall down the stairs—save a little girl’s life
Photo: Kate Ackermann Photography Liz Beaulieu is likely the only person in the world who can say she saved her child by falling down the stairs. Her daughter, Arielle, was just 4 days old. Liz was carrying her downstairs when she slipped. Not sure whether Arielle had hit her head, she whisked her to her local ER. “She seemed fine, and they said that she looked fine,” Liz says. Still concerned, though, Liz kept a close eye on Arielle over the next couple of days. That’s when she noticed something. “I noticed the slightest flicker of her eyes,” Liz recalls, “and decided that I wanted to g...
Source: Thrive, Children's Hospital Boston - July 8, 2015 Category: Pediatrics Authors: Tom Ulrich Tags: Diseases & conditions Our patients’ stories Brain tumor congenital intracranial teratoma CT scan Dana-Farber/Boston Children's Cancer and Blood Disorders Center Liliana Goumnerova Mark Kieran Source Type: news
Teratomas: the tumours that can transform into ‘evil twins’
Look away if you’re squeamish – our bodies are capable of creating macabre structures when our cells go awry, and this lump of bone, hair and teeth is just one of them Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - April 27, 2015 Category: Science Authors: Aarathi Prasad Tags: Cancer Medical research Health Science Source Type: news
"Evil twin" sibling growing in woman's brain
Woman awakens from surgery to learn that her brain tumor was actually a teratoma, a tiny remnant of a twin fetus (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - April 23, 2015 Category: Consumer Health News Source Type: news
Surgeon Finds 'Embryonic Twin' Inside Woman's Brain: Report
It was worrying: the young woman started having difficulty comprehending things she read and heard, and when many people were speaking in a room at once, she found it hard to understand what was happening. Doctors soon discovered a tumor in her brain. But when she underwent surgery, the surgeon found something startling. The tumor was actually the woman's "embryonic twin." This may all sound like an episode of a fictitious drama series, but according to NBC Los Angeles, it’s the true story of 26-year-old Yamini Karanam, an Indiana University PhD student. Karanam recently underwent the minimally-invasive...
Source: Healthy Living - The Huffington Post - April 22, 2015 Category: Consumer Health News Source Type: news
Teratomas: the tumours that can transform into ‘evil twins’
Look away if you’re squeamish – our bodies are capable of creating macabre structures when our cells go awry, and this lump of bone, hair and teeth is just one of themMaking the weird news last week was Yamini Karanam, who underwent surgery in Los Angeles after being diagnosed with a brain tumour. The benign lump became a sensation when it turned out to be a grotesque growth containing bone, hair and teeth. Known to medical science as a teratoma (from the Greek for “monstrous tumour”), news wires quoted Karanam’s post-surgical joke that it was her “evil twin sister” who’d bee...
Source: Guardian Unlimited Science - November 18, 2014 Category: Science Authors: Aarathi Prasad Tags: Cancer Medical research Health Science Source Type: news
What Treatment is Available for Lymphatic Malformations?
Discussion Vascular malformations including those of the arterial, venous and lymphatic systems are due to an arrest of the normal process of angiogenesis, vasculogenesis and remodeling of the vessels. They are not tumors and need to be differentiated from benign and malignant vascular lesions. They occur in 1.5% of the population with 90% present at birth. The nomenclature of congenital lymphatic malformations can be confusing. They can be present in any location and may have mixed elements within them (i.e. lymphatic and venous, lymphatic and arterial, etc.) and different structural components such as dilatation or hype...
Source: PediatricEducation.org - April 21, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Could stem cell research spell the end of baldness?
Conclusion The researchers have developed a method of growing human stem cells from human skin samples. They have developed a technique to induce them into becoming epithelial (skin) stem cells and demonstrated they can produce some of the cells found in skin such as hair follicles, keratin and epithelial cells. These techniques will be useful and encouraging to other researchers in this field who are looking into the regeneration of hair follicles and skin for humans. However, the research is in its early stages so we shouldn’t jump the gun and expect treatments based on it to arrive shortly. There may be...
Source: NHS News Feed - January 29, 2014 Category: Consumer Health News Tags: Genetics/stem cells Medical practice Lifestyle/exercise Source Type: news
Adult cells turned into stem cells in the body
Conclusion This study is the first to induce stem cells within the body of an adult mouse, without the need to take the cells out of the body. The way that the researchers achieved this required the use of genetically engineered mice whose cells all had the genetic capacity to “reprogramme” into stem cells when treated with a specific drug. When these mice were given the drug, some of their cells “reprogrammed”, and some of these went on to form tumours. The technique used in this study is clearly not something that can be directly applied to humans – who cannot be genetically engineered in t...
Source: NHS News Feed - September 12, 2013 Category: Consumer Health News Tags: Genetics/stem cells Source Type: news
Must-read: Anti-NMDA Receptor Encephalitis
4.5 out of 5 stars Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis: an etiology worth considering in the differential of delirium. Punja M et al. Clin Toxicol 2013 Aug 20 [Epub ahead of print] Abstract This important paper is a must-read, especially for toxicologists who have not heard of this under-appreciated neurological disorder. (I was not aware of it until several days ago, when I found out that a friend of a relative had received the diagnosis.) Anti-NMDA encephalitis was first described in 2005. Advanced cases often develop altered mental status, autonomic instability, increased muscle tone, ...
Source: The Poison Review - August 28, 2013 Category: Toxicology Authors: Leon Tags: Best of TPR Medical anti-n-methyl-d-aspartate receptor anti-NMDA receptor encephalitis autoimmune neurologic Source Type: news
Twisted Benign Ovarian TeratomaTwisted Benign Ovarian Teratoma
What was the origin of this 35-year-old woman's sudden lower abdominal pain accompanied by vomiting and generalized pruritus? Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 12, 2013 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Journal Article Source Type: news
Fat chance: Scientists unexpectedly discover stress-resistant stem cells in adipose tissue
Researchers from the UCLA Department of Obstetrics and Gynecology have isolated a new population of primitive, stress-resistant human pluripotent stem cells that are easily derived from fat tissue and are able to differentiate into virtually every cell type in the human body without genetic modification. The cells, called multi-lineage stress-enduring stem cells from adipose tissue (Muse-AT), were discovered by "scientific accident" when a piece of equipment failed in the laboratory, killing all the stem cells in an experiment except the Muse-AT cells. The UCLA team further discovered that not only ...
Source: UCLA Newsroom: Health Sciences - June 5, 2013 Category: Universities & Medical Training Source Type: news
What is Immature Teratoma?
Immature teratomas of the ovary are rare germ cell malignancies. They are very different from the more common mature cystic teratoma, which is not malignant. (Source: About.com Ovarian Cancer)
Source: About.com Ovarian Cancer - June 5, 2013 Category: Cancer & Oncology Authors: ovariancancer.guide at about.com Tags: health Source Type: news
Identification Of Small Molecule That Destroys Potentially Dangerous Cells May Improve Stem Cell Therapies
Pluripotent stem cells can turn, or differentiate, into any cell type in the body, such as nerve, muscle or bone, but inevitably some of these stem cells fail to differentiate and end up mixed in with their newly differentiated daughter cells. Because these remaining pluripotent stem cells can subsequently develop into unintended cell types - bone cells among blood, for instance - or form tumors known as teratomas, identifying and separating them from their differentiated progeny is of utmost importance in keeping stem cell-based therapeutics safe... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 25, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news
Method makes it easier to separate useful stem cells from 'problem' ones for therapies
Pluripotent stem cells can turn, or differentiate, into any cell type in the body, such as nerve, muscle or bone, but inevitably some of these stem cells fail to differentiate and end up mixed in with their newly differentiated daughter cells. Because these remaining pluripotent stem cells can subsequently develop into unintended cell types — bone cells among blood, for instance — or form tumors known as teratomas, identifying and separating them from their differentiated progeny is of utmost importance in keeping stem cell–based therapeutics safe. Now, UCLA scientists have discovered ...
Source: UCLA Newsroom: Health Sciences - April 22, 2013 Category: Universities & Medical Training Source Type: news
Retroperitoneal Teratoma With Malignant TransformationRetroperitoneal Teratoma With Malignant Transformation
This interesting report describes a case of papillary renal cell carcinoma in a metastatic testicular germ cell tumor. BMC Urology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 17, 2013 Category: Consumer Health News Tags: Urology Journal Article Source Type: news