UCLA scientists use stem cells to study genetics of germ cell tumors
UCLA researchers have made new inroads into understanding germ cell tumors, a diverse and rare group of cancers that begin in germ cells — the cells that develop into sperm and eggs. The researchers developed a protocol to recreate germ cell tumor cells from stem cells and used the new model to study the genetics of the cancer.Their findings could point the way toward new drugs to treat germ cell tumors, which account for around 3 percent of all cases of childhood and adolescent cancer.The study, published in Stem Cell Research, was led by Amander Clark, a UCLA professor of molecular cell and developmental biology and a member of theEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.Germ cell tumors most often develop during embryonic development, in the testes and ovaries, but they can also occur in the spine, chest and brain when germ cells mistakenly migrate there.UCLA Broad Stem Cell Research Center/ElsevierEmbryonal carcinoma cells expressing the PRDM14 proteinThere are five subtypes of germ cell tumors: germinomas, embryonal carcinomas, yolk sac tumors, choriocarcinomas and teratomas. Each has its own unique properties, but most of them affect young children, adolescents and young adults.“What makes this cancer really hard to study is that we think the disease begins in the womb and then remains latent until after birth or during young adulthood,” Clark said. “That means we can’t easily isolate or study the ...
I think it is entirely appropriate to greet the advent of senolytics with enthusiasm. These treatments are the first legitimate rejuvenation therapies to successfully target one of the root causes of aging, the accumulation of lingering senescent cells in old tissues. The first human trial data is approaching publication, but even before it arrives, the evidence to date strongly suggests that meaningful levels of rejuvenation can be achieved in old people at a very low cost. The first senolytic drugs (such as dasatinib and navitoclax) and plant extracts (such as fisetin and piperlongumine) cost very little, and remove only...
Naturally grown tissues are intricately structured, and the physical properties of tissue derive from the patterning of cells and their behavior in generating a supporting extracellular matrix. This natural complexity ensures that there is still a great deal of work to be accomplished when it comes to the 3-D bioprinting of functional tissue structures; not all tissues can be produced using the current state of the art systems, or at least not in a useful state. The work here is an example of the sort of incremental advance needed to produce tissues that are closer in form and function to those growing naturally inside bod...
Kaiser Khan, now 24, , from Stratford-upon-Avon, Warwickshire, was eventually forced to drop out of Liverpool John Moores University when his itching became unbearable.
PROSTATE cancer symptoms are not always apparent in the early stages because they usually don ’t show until the tumour has grown and put pressure on other parts of the body. But when signs do begin to show, one to be wary of is in the hips.
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ConclusionAdding neoadjuvant chemotherapy to S or RT cannot be recommended outside the context of clinical trials.
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