Solving the mystery of a shapeshifting neck tumor

Jaedin, 10 years old, holds the control for a remote-controlled race car, Christmas 2017. Amanda Brown couldn’t shake an uneasy intuition that something just seemed “off” throughout her second pregnancy. During a scheduled caesarian section at her local hospital in North Carolina, her instinct proved to be true. “I had given birth to my first son by C-section so I knew what to expect,” Amanda says. “But this time around, as the surgeons totally stalled in the middle of the delivery, I thought to myself, ‘it doesn’t take this long to pull a baby out.’” When her son Jaedin was finally delivered, Amanda and her husband were shocked by their first sight of him. “Jaedin had a huge mass on the left side of his neck that looked like it was growing out of his ear,” Amanda says. “The doctors told us they didn’t know what the mass was and that they would have to take him to a nearby children’s hospital right away.” Living in scary uncertainty There, doctors guessed that the cause of Jaedin’s mass might be a lymphatic malformation (LM), a group of abnormal growths that contain fluid. Yet although they extracted a large amount of fluid from his mass, they were troubled to see that the mass was filling back up with fluid and rapidly changing its shape. It seemed that it might not be a lymphatic malformation after all. By the time Jaedin was a month old, Amanda’s stepmother went onli...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & Conditions Our Patients’ Stories Center for Airway Disorders cervical teratoma Dr. Reza Rahbar germ cell tumor Neck and Skullbase Surgery Program at Boston Children's NICU Solid Tumors Center at Dana-Farber/Boston Children's Source Type: news

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Publication date: Available online 19 October 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Adriana L. Clementz, Debora Manuale, Esteban Sanchez, Carlos Vera, Juan C. YoriAbstractThe reutilization of agroindustrial wastes for the production of new products is an attractive option for reducing environmental pollution, generating value-added products and decreasing costs. Slaughterhouse discard bovine bone, brewery discard yeast and carrot discards from the Santa Fe province (Argentina) were used for producing ethanol. Bovine bone and yeast provided the support and active phase for fermentation biocatalys...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Publication date: 15 February 2020Source: Journal of Molecular Structure, Volume 1202Author(s): Yu Yang, Jiang-Yu Bian, Yu-Han Li, Hui-Chao Guan, Yan-Ru Tang, Yan-Ling Chen, Shu-Mei YueAbstractSix complexes including [Cd (bpt)(odc)2] (1), [Ni(bpt)(odc)2] (2), [Zn (bpt)(odc)2] (3), [Zn (bpt)(1,4-ndc)2(H2O)] (4), [Cd (bpt)(1,4-ndc)2] (5), [Cd (bpt)(Pta)2(H2O)2] (6), {bpt = 2-(2 pyridyl)benzothiazole, H2odc = 4,4′-oxybisbenzoic acid, 1,4-H2ndc = naphthalene-1,4-dicarboxylic acid, Pta = terephthalic acid}, have been determined by single-crystal X-ray diffraction analysis, which shows that complexes 1&ndas...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 19 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Brittany Haynes, Ambikai Gajan, Pratima Nangia-Makker, Malathy P. ShekharAbstractTriple negative breast cancer (TNBC) is an aggressive breast cancer subtype with few therapy options besides chemotherapy. Although platinum-based drugs have shown initial activity in BRCA1-mutated TNBCs, chemoresistance remains a challenge. Here we show that RAD6B (UBE2B), a principal mediator of translesion synthesis (TLS), is overexpressed in BRCA1 wild-type and mutant TNBCs, and RAD6B overexpression correlate...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
In this study, we compared differences in gene expression in parental and CHD4-deficient cells by next-generation sequencing and Ingenuity Pathway Analysis.Key findingsWe found that β1 integrin is a downstream target gene of CHD4, which could be transcriptionally regulated by CHD4 in TNBC cells. Consistent with in vitro data, immunohistochemistry revealed that co-expression of β1 integrin and CHD4 was significantly associated with metastatic state, recurrence, and survival status in TNBC patients. It also showed a positive correlation between β1 integrin and CHD4 in vivo.SignificanceThis is the first study t...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 19 October 2019Source: Carbohydrate PolymersAuthor(s): Katarzyna Ratajczak, Magdalena StobieckaAbstractA remarkable progress in the development of portable paper-based biosensors (PBBs) and microfluidic paper-based analytical devices (µPADs) has recently been achieved. In these devices, a paper formed of microfibers of cellulose, a carbohydrate biopolymer, offers both an ample space in its micropores for analytical reagents storage and a capillary force to drive liquid samples to a dedicated reaction zone for instantaneous detection of the desired analytes. Owing to the low cost and...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
CONCLUSIONSː NOACs reduced all-cause mortality in patients with or at risk for CAD or PAD, even though they increased the risk of major bleeding. Future studies regarding the best doses of NOACs are warranted. PMID: 31625706 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Publication date: Available online 19 October 2019Source: Mutation Research/Genetic Toxicology and Environmental MutagenesisAuthor(s): Ketsia Sabrina do Nascimento Marinho, Clovis José Cavalcanti Lapa Neto, Ilka Dayane Duarte de Sousa Coelho, Meykson Alexandre da Silva, Maria Eduarda Gomes Melo, Katharine Raquel Pereira dos Santos, Cristiano Aparecido Chagas, Álvaro Aguiar Coelho Teixeira, Valéria Wanderley TeixeiraAbstractExposure of pregnant women to pesticides in an occupational or incidental manner has been pointed out as a possible cause of health problems in newborns. Cypermethrin and methomyl ar...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 19 October 2019Source: Genes &DiseasesAuthor(s): Weijie Guo, Binhua P. ZhouAbstractMetabolic abnormalities are emerging as an active driver to the development, progression and metastasis of various tumors. In the recent issue of the EMBO Journal, Yang and colleagues identified that succinylacetone (SA) could act as an oncometabolite and that accumulation of SA activates the NRF2/IGF1R axis in hepatocellular carcinoma (HCC) development. These discoveries not only yield great insights in the understanding of tumor biology, but also hold significant clinical ramifications, as these findi...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
In this report, we analyzed gene expression profiles of paired specimens of keratinocyte carcinomas with their matched normal skin tissues as the control. Among several novel findings, we discovered a significant number of zinc finger encoding genes up-regulated in human BCC. In BCC, a novel link was found between hedgehog signaling, Wnt signaling, and the cilium. While the SCC cancer-stem-cell gene signature is shared between human and mouse SCCs, the hair follicle stem-cell signature of mice was not highly represented in human SCC. Differential gene expression (DEG) in human BCC shares gene signature with both bulge and ...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
In this study, we report a successful enucleation of a giant BPH (1070 g) without any significant complications.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
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