Fight Aging! Newsletter, October 17th 2022

This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity. A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of whom 89,201 participants (43.1%) had multimorbidity. Over a mean of 11.8 years of follow-up, 6,182 participants (3.0%) developed dementia. The incidence rate was 1.87 per 1,000 person-years for those without multimorbidity and 3.41 per 1,000 person-years for those with multimorbidity. In Cox proportional hazards models adjusted for age, sex, ethnicity, education, socioeconomic status, and APOE-ε4 carrier status, multimorbidity was associated with an increased risk of incident dementia (hazard ratio [HR], 1.63). The highest dementia risk was observed for the hypertension, diabetes, and coronary heart disease cluster (HR 2.20) and pain, osteoporosis, and dyspepsia cluster (HR 2.00) in women and in the diabetes and hypertension cluster (HR 2.24) and coronary heart disease, hypertension, and stroke cluster (HR 1.94) in men, compared with no multimorbidi...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs