Fight Aging! Newsletter, August 29th 2022

This study demonstrates that adoptive astrocytic Mt transfer enhances neuronal Mn-SOD-mediated anti-oxidative defense and neuroplasticity in the brain, which potentiate functional recovery following ICH. First Generation Stem Cell Therapies Remain Comparatively Poorly Understood https://www.fightaging.org/archives/2022/08/first-generation-stem-cell-therapies-remain-comparatively-poorly-understood/ We are something like thirty years into the increasingly widespread use of first generation stem cell therapies. Cells are derived from a variety of sources, processed, and transplanted into patients. Near all of these transplanted cells die, but while they survive they secrete signals that suppress inflammation and encourage native cells to change their behavior for the better. It is fair to argue that these treatments have not yet realized the potential originally hoped for, the robust regeneration of damaged tissues. While suppression of inflammation is reliably achieved, regeneration and restored function for organs occurs in only some patients, and to a varying, modest degree. More generally, not enough is known of how these therapies produce beneficial effects, or of the way in which cells interact in these circumstances. That leads to discussions such as the one offered in today's open access paper, in which clinicians look over their data to make the empirical observation that some sources of cells are better than others for treating specific condi...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs