Medical News Today: Manganese and Parkinson's: Mechanism may explain link
New research discovers a mechanism that may explain why exposure to manganese induces Parkinson's symptoms. The findings may aid diagnosis and treatment. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 15, 2019 Category: Consumer Health News Tags: Parkinson's Disease Source Type: news

Manganese and Parkinson's: Mechanism may explain link
New research discovers a mechanism that may explain why exposure to manganese induces Parkinson's symptoms. The findings may aid diagnosis and treatment. (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - March 15, 2019 Category: Neurology Tags: Parkinson's Disease Source Type: news

Manganese spreads neurodegeneration
(Source: ScienceNOW)
Source: ScienceNOW - March 14, 2019 Category: Science Authors: Ferrarelli, L. K. Tags: twis Source Type: news

Researchers explore link between metal exposure and Parkinson's symptoms
(Iowa State University) A new study from an Iowa State University biomedical researcher describes the biological process that causes Parkinson's-like symptoms to develop following exposure to the metal manganese. The new research, published in the journal Science Signaling, could lead to earlier detection of Parkinson's disease and better outcomes for patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 13, 2019 Category: International Medicine & Public Health Source Type: news

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of {alpha}-synuclein
The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a prion-like, cell-to-cell transfer of misfolded αSyn has been recognized in the spreading of αSyn pathology in synucleinopathies, we investigated the biological mechanisms underlying the propagation of the disease with respect to environmental neurotoxic stress. Considering the potential role of the divalent metal manganese (Mn2+) in protein aggregation, we characterized its effect on αSyn misfolding and transmission in ...
Source: Signal Transduction Knowledge Environment - March 12, 2019 Category: Science Authors: Harischandra, D. S., Rokad, D., Neal, M. L., Ghaisas, S., Manne, S., Sarkar, S., Panicker, N., Zenitsky, G., Jin, H., Lewis, M., Huang, X., Anantharam, V., Kanthasamy, A., Kanthasamy, A. G. Tags: STKE Research Articles Source Type: news

Linking Mn2+, {alpha}-synuclein, and neuroinflammation
Several studies elucidate the molecular links between manganese exposure and Parkinson’s disease. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 12, 2019 Category: Science Authors: Ferrarelli, L. K. Tags: STKE Editors ' Choice Source Type: news

How to cultivate watercress at home
(Natural News) Watercress is easily one of the most nutritious greens in the plant kingdom. This green, leafy salad staple is an excellent source of carotenoids, manganese, and vitamins B1, B2, and B6 as well as vitamins C and E. Watercress is also packed with fiber, iron, copper, and iron. The vegetable is known to have anticancer... (Source: NaturalNews.com)
Source: NaturalNews.com - February 21, 2019 Category: Consumer Health News Source Type: news

Herbs vs. pharmaceuticals: Understanding the effectiveness of natural medicine
(Natural News) Few would argue over the importance of trace elements when it comes to human nutrition. Though only a small amount of these essential nutrients is required, they are nonetheless integral to your well-being. Trace elements include nutrients such as copper, iron, manganese, selenium and zinc. But when it comes to natural cures, it... (Source: NaturalNews.com)
Source: NaturalNews.com - January 31, 2019 Category: Consumer Health News Source Type: news

Scoliosis Linked to Gene Variant Inhibiting Manganese Utilization
No abstract available (Source: Lippincott's Bone and Joint Newsletter)
Source: Lippincott's Bone and Joint Newsletter - January 16, 2019 Category: Orthopaedics Tags: Trends and Innovations Source Type: news

How manganese produces a parkinsonian syndrome
(CNRS) Using X-ray fluorescence at synchrotrons DESY and ESRF, researchers in the Centre d'Etudes Nucl é aires de Bordeaux Gradignan (CNRS/Universit é de Bordeaux) have demonstrated the consequences of a mutation responsible for a hereditary parkinsonian syndrome: accumulated manganese in the cells appears to disturb protein transport. This work, carried out with colleagues at the University of Texas at Austin (USA), was published in ACS Chemical Neuroscience on January 16, 2018. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 16, 2019 Category: Biology Source Type: news

Pineapples offer you enormous health benefits and can even help the body fight off chronic disease
(Natural News) On hot summer days, a lot of people look forward to eating sweet and juicy pineapples. However, even if it’s not yet summer, there are still plenty of reasons why you should enjoy this tropical fruit. Pineapples are packed with vitamins and minerals, such as vitamin C, manganese, vitamin B6, copper, thiamine, folate, potassium, and magnesium. Aside... (Source: NaturalNews.com)
Source: NaturalNews.com - January 13, 2019 Category: Consumer Health News Source Type: news

Manganese mobilizes microglial exosomes
(Source: ScienceNOW)
Source: ScienceNOW - January 10, 2019 Category: Science Authors: Williams, E. Tags: twis Source Type: news

Researchers diversify drug development options with new metal catalyst
(University of Illinois at Urbana-Champaign) A University of Illinois team of researchers led by chemistry professor M. Christina White has developed a new manganese-based catalyst that can change the structure of druglike molecules to make new drugs, advancing the pace and efficiency of drug development. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 9, 2019 Category: International Medicine & Public Health Source Type: news

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
In this study, we examined whether Mn2+ activates the multiprotein NLRP3 inflammasome complex to promote neuroinflammation. Exposing activated mouse microglial cells to Mn2+ substantially augmented NLRP3 abundance, caspase-1 cleavage, and maturation of the inflammatory cytokine interleukin-1β (IL-1β). Exposure of mice to Mn2+ had similar effects in brain microglial cells. Furthermore, Mn2+ impaired mitochondrial ATP generation, basal respiratory rate, and spare capacity in microglial cells. These data suggest that Mn-induced mitochondrial defects drove the inflammasome signal amplification. We found that Mn induc...
Source: Signal Transduction Knowledge Environment - January 8, 2019 Category: Science Authors: Sarkar, S., Rokad, D., Malovic, E., Luo, J., Harischandra, D. S., Jin, H., Anantharam, V., Huang, X., Lewis, M., Kanthasamy, A., Kanthasamy, A. G. Tags: STKE Research Articles Source Type: news

Here are 9 amazing benefits of regularly drinking lemongrass tea
(Natural News) Lemongrass is a tropical herb that has a citrus smell and taste. This tall, stalky plant is also known for its medicinal properties. It is rich in essential vitamins and minerals, such as vitamins A and C, calcium, magnesium, folate, iron, zinc, potassium, copper, phosphorus, manganese, and traces of B vitamins. While it... (Source: NaturalNews.com)
Source: NaturalNews.com - December 5, 2018 Category: Consumer Health News Source Type: news

Should You Develop Your Own Material Specification and Skip ASTM ’s?
The basic format for an ASTM standardized metal alloy for medical uses includes a specification of the required elements as well as one or more undesirable elements for which there is a maximum allowable amount. For example, ASTM F2886, last approved in 2017, covers Metal Injection Molded Cobalt-28Chromium-6Molybdenum Components for Surgical Implant Applications. While the name gives part of the recipe, a more-detailed list of elements specifies that chromium must be between 27 and 30%, and molybdenum between 5 and 7%. Thus, these major required alloying elements together constitute 32 to 37% of the mix. Twelve other eleme...
Source: MDDI - November 6, 2018 Category: Medical Devices Authors: William A. Hyman Tags: Regulatory and Compliance Source Type: news

Are Sunflower Seeds Healthy? Here ’s What Experts Say
Certain seeds, like chia and flax, tend to hog the nutritional spotlight. But the less-trendy sunflower seed has plenty of qualities worth highlighting. Here are the health benefits of sunflowers seeds, according to dietitians. Are sunflower seeds healthy? Sunflower seeds are rich in nutrients. One serving of shelled sunflower seeds is usually an ounce, which is about 1/4 cup or 4 tablespoons (one to two thumb-sized portions.) They’re particularly high in healthy fat: A serving delivers 14 grams of fat with a mix of monounsaturated and polyunsaturated fats. “The mono- and polyunsaturated fats in sunflower seed...
Source: TIME: Health - October 17, 2018 Category: Consumer Health News Authors: Cassie Shortsleeve  Tags: Uncategorized Diet/Nutrition Source Type: news

Scoliosis linked to inability to utilize manganese
A curvature of the spine known as scoliosis has been linked to the body's inability to utilize the essential dietary mineral manganese, according to a study. (Source: Health News - UPI.com)
Source: Health News - UPI.com - October 9, 2018 Category: Consumer Health News Source Type: news

Scoliosis linked to essential mineral
(Washington University School of Medicine) An inability to properly use the essential mineral manganese could be to blame for some cases of severe scoliosis, according to a new study from Washington University School of Medicine in St. Louis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 9, 2018 Category: International Medicine & Public Health Source Type: news

Manganese plays a key role in bacterial infection
(PLOS) The ability to acquire manganese during infection is essential for the virulence of Enterococcus faecalis in animals, according to a study published Sept. 20, 2018 in the open-access journal PLOS Pathogens by Jos é Lemos of the University of Florida College of Dentistry, and colleagues. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 20, 2018 Category: Biology Source Type: news

Point-of-care sensors to detect manganese from single drop of blood
(University of Illinois at Chicago) A three-year, $1.8 million grant from the National Institutes of Health will enable researchers at the University of Illinois at Chicago to develop portable, easy-to-use sensors that can detect toxic metals in a single drop of blood. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 13, 2018 Category: Biology Source Type: news

Kent State geologist wins grant to study climate change, inspire young scientists
(Kent State University) The National Science Foundation (NSF) presented its prestigious Faculty Early Career Development (CAREER) Award to Dr. Herndon for her project, 'Manganese Biogeochemistry and Impacts on Carbon Storage in Plant-Soil Systems.' The five-year grant is expected to total $487,000. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 13, 2018 Category: Biology Source Type: news

Manganese (Manganese Chloride Injection Solution) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 7, 2018 Category: Drugs & Pharmacology Source Type: news

Medical News Today: What are the benefits of barley water?
Barley is a great source of fiber and contains many other essential minerals, including magnesium, manganese, and selenium. In this article, we look at the benefits of barley water and how to make this nutritious beverage. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 23, 2018 Category: Consumer Health News Tags: Nutrition / Diet Source Type: news

The 6 Best Snacks for Anyone Cutting Out Sugar, According to a Nutritionist
This article originally appeared on Health.com (Source: TIME: Health)
Source: TIME: Health - February 28, 2018 Category: Consumer Health News Authors: Cynthia Sass, MPH, RD Tags: Uncategorized Food Healthy Eating onetime Source Type: news

Toxic Metals Found in E-Cigarette Vapor
The team found that e-liquid exposed to heating coils produced a vapor containing significant amounts of chromium, lead, manganese, nickel and zinc. (Source: WebMD Health)
Source: WebMD Health - February 26, 2018 Category: Consumer Health News Source Type: news

Rigaku Publishes Method For Measurement Of Manganese In Gasoline
A new application report from Applied Rigaku Technologies, Inc. demonstrates the analysis of manganese (Mn) in gasoline by energy dispersive X-ray fluorescence(PRWeb January 26, 2018)Read the full story at http://www.prweb.com/releases/2018/01/prweb15135893.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - January 26, 2018 Category: Pharmaceuticals Source Type: news

Manganese-based MRI contrast agent may be safer alternative to gadolinium-based agents
(Massachusetts General Hospital) A team of Massachusetts General Hospital researchers has developed a manganese-based magnetic resonance imaging contrast agent, a potential alternative to gadolinium-based agents, which carry significant health risks for some patients (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 15, 2017 Category: International Medicine & Public Health Source Type: news

Washington University gets $3.7 million to study neurological disorders
Washington University has received $3.7 million in funding from the National Institutes of Health to study neurological disorders linked to manganese, an element found in smoke from steel production and coal fires. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - October 16, 2017 Category: American Health Authors: Angela Mueller Source Type: news

Medical News Today: Too much manganese may lower children's IQ
A study suggests that excessive air exposure to manganese may have negative neurodevelopmental effects; high levels of the metal correlate with lower IQ. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 25, 2017 Category: Consumer Health News Tags: Public Health Source Type: news

Medical News Today: Too much manganese may lead to fatal heart infection
New research finds that excessive intake of manganese, an essential nutrient in leafy vegetables, may lead to a Staphylococcus aureus heart infection. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 22, 2017 Category: Consumer Health News Tags: Nutrition / Diet Source Type: news

Excess dietary manganese promotes staph heart infection
(Vanderbilt University Medical Center) Too much dietary manganese -- an essential trace mineral found in leafy green vegetables, fruits and nuts -- promotes infection of the heart by the bacterium Staphylococcus aureus. The findings, reported this week in Cell Host& Microbe, add to evidence that diet modifies risk for infection and suggest that people who have excess levels of tissue manganese, potentially from dietary supplements, may be at increased risk for staph infection of the heart. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 21, 2017 Category: Infectious Diseases Source Type: news

Higher manganese levels in children correlate with lower IQ scores, UC study finds
(University of Cincinnati Academic Health Center) A study led by environmental health researchers at the University of Cincinnati (UC) College of Medicine finds that children in East Liverpool, Ohio with higher levels of Manganese (Mn) had lower IQ scores. The research appears online in the journal NeuroToxicology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 21, 2017 Category: International Medicine & Public Health Source Type: news

Traces of Tattoo May Reach the Lymph Nodes
WEDNESDAY, Sept. 13, 2017 -- Microscopic particles from tattoos can travel within the body and reach the lymph nodes, researchers say. Along with pigments, tattoo inks contain preservatives and contaminants such as nickel, chromium, manganese and... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 13, 2017 Category: General Medicine Source Type: news

High dislocation density-induced large ductility in deformed and partitioned steels
A wide variety of industrial applications require materials with high strength and ductility. Unfortunately, the strategies for increasing material strength, such as processing to create line defects (dislocations), tend to decrease ductility. We developed a strategy to circumvent this in inexpensive, medium manganese steel. Cold rolling followed by low-temperature tempering developed steel with metastable austenite grains embedded in a highly dislocated martensite matrix. This deformed and partitioned (D and P) process produced dislocation hardening but retained high ductility, both through the glide of intensive mobile d...
Source: ScienceNOW - September 7, 2017 Category: Science Authors: He, B. B., Hu, B., Yen, H. W., Cheng, G. J., Wang, Z. K., Luo, H. W., Huang, M. X. Tags: Engineering, Materials Science reports Source Type: news

Trump ’ s Halt on Coal Mining Study Has Asbestos Implications
The U.S. Department of the Interior has ordered a halt to a study on the public health risks of mountaintop removal mining in Appalachia — an area ripe with natural asbestos deposits. A letter from the Interior Department on Monday directed the National Academies of Sciences, Engineering and Medicine to “cease all work” on the study, citing responsible spending of taxpayer dollars as the reason for the decision. The $1 million National Academies study began in 2016 and was expected to take two years to complete. It aimed to evaluate health risks of a common mining technique for people living near surfac...
Source: Asbestos and Mesothelioma News - August 24, 2017 Category: Environmental Health Authors: Matt Mauney Tags: Appalachian Mountains arsenic asbestos exposure Appalachia asbestos exposure coal mining asbestosis coal mining Bill Price Central Appalachia coal mining Appalachia Donald Trump Environmental Health Perspectives Glenda Owens House Co Source Type: news

Manganese in underground drinking water is cause for concern
(University of California - Riverside) Underground drinking water sources in parts of the US and three Asian countries may not be as safe as previously thought due to high levels of manganese, especially at shallow depths, according to a study led by a researcher at the University of California, Riverside. Manganese, a metal that is required by the body in tiny amounts, can be toxic at elevated levels, particularly in children. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 24, 2017 Category: International Medicine & Public Health Source Type: news

Metal-catalyzed electrochemical diazidation of alkenes
We report an operationally simple and environmentally friendly protocol that converts alkenes and sodium azide—both readily available feedstocks—to 1,2-diazides. Powered by electricity and catalyzed by Earth-abundant manganese, this transformation proceeds under mild conditions and exhibits exceptional substrate generality and functional group compatibility. Using standard protocols, the resultant 1,2-diazides can be smoothly reduced to vicinal diamines in a single step, with high chemoselectivity. Mechanistic studies are consistent with metal-mediated azidyl radical transfer as the predominant pathway, enablin...
Source: ScienceNOW - August 10, 2017 Category: Science Authors: Fu, N., Sauer, G. S., Saha, A., Loo, A., Lin, S. Tags: Chemistry reports Source Type: news

Baby teeth link autism with metal uptake, in NIEHS-funded study
Baby teeth from children with autism contain more toxic lead and less zinc and manganese than in children without autism, say NIEHS-funded researchers. (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - July 4, 2017 Category: Environmental Health Source Type: news

Low levels of manganese in welding fumes cause neurological problems
(Washington University School of Medicine) Welders exposed to airborne manganese at estimated levels under federal occupational safety standards exhibit neurological problems similar to Parkinson's disease, according to new research at Washington University School of Medicine in St. Louis. Further, the more they are exposed to manganese-containing welding fumes, the faster the workers' signs and symptoms worsen. The findings suggest that current safety standards may not adequately protect welders from the dangers of the job. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 28, 2016 Category: Global & Universal Source Type: news

Early exposure to too much manganese causes attention deficits in rats
Too much manganese early in development causes lasting attention deficits and other impairments in rats. Studies of children and adolescents have associated excess manganese in the diet with attention deficits, but confounding factors in those studies have made it impossible to show a cause and effect relationship. The new study is the first to establish a causal link between exposure to elevated manganese in the diet and attentional dysfunction in an animal model. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - August 23, 2016 Category: Science Source Type: news

Early exposure to manganese causes attention deficits in rats
(University of California - Santa Cruz) Too much manganese early in development causes lasting attention deficits and other impairments in rats. Studies of children and adolescents have associated excess manganese in the diet with attention deficits, but confounding factors in those studies have made it impossible to show a cause and effect relationship. The new study is the first to establish a causal link between exposure to elevated manganese in the diet and attentional dysfunction in an animal model. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 23, 2016 Category: Global & Universal Source Type: news

Neurotoxicity in the NICU: Is Manganese a Villain?Neurotoxicity in the NICU: Is Manganese a Villain?
Many preterm infants are receiving excessive amounts of a known neurotoxin. What's being done about manganese? Medscape Nurses (Source: Medscape Nurses Headlines)
Source: Medscape Nurses Headlines - March 14, 2016 Category: Nursing Tags: Nursing Viewpoint Source Type: news

The best natural sources of manganese
(NaturalNews) Manganese is a trace mineral that is present in only small amounts in our bodies. It is considered an essential nutrient and is responsible for a large number of biological roles, including proper enzyme functioning, wound healing, nutrient absorption and bone development... (Source: NaturalNews.com)
Source: NaturalNews.com - January 9, 2015 Category: Consumer Health News Source Type: news

Childhood exposure to manganese and postural instability in children living near a ferromanganese refinery in southeastern Ohio - Rugless F, Bhattacharya A, Succop P, Dietrich KN, Cox C, Alden J, Kuhnell P, Barnas M, Wright R, Parsons PJ, Praamsma ML, Palmer CD, Beidler C, Wittberg R, Haynes EN.
Airborne manganese (Mn) exposure can result in neurotoxicity and postural instability in occupationally exposed workers, yet few studies have explored the association ambient exposure to Mn in children and postural stability. The goal of this study was to ... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - January 11, 2014 Category: Global & Universal Tags: Age: Infants and Children Source Type: news

Nutrition 101: Manganese
(HealthCastle.com) Manganese is a trace mineral present in tiny amounts in the body. It is found mostly in bones, the liver, the kidneys, and the pancreas. Reco​mme​nded Intake The Dietary Reference Intakes (DRI) for manganese are shown below: read more (Source: HealthCastle.com Nutrition Tips - written by Registered Dietitians)
Source: HealthCastle.com Nutrition Tips - written by Registered Dietitians - November 25, 2013 Category: Nutrition Source Type: news

Elevated manganese exposure and school-aged children's behavior: A gender-stratified analysis - Menezes-Filho JA, de Carvalho-Vivas CF, Viana GF, Ferreira JR, Nunes LS, Mergler D, Abreu N.
The objective of the present study was to examine behavioral ... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - October 19, 2013 Category: Global & Universal Tags: Age: Adolescents Source Type: news

Welding Fume Judge Recommends Dissolving Consolidation Of Manganese Injury Cases
CLEVELAND - The multidistrict litigation created in June 2003 by the Judicial Panel on Multidistrict Litigation in the U.S. District Court for the Northern District of Ohio for personal injury claims allegedly caused by inhalation of welding fumes containing manganese was dissolved March 25 (In re: Welding Fume Products Liability Litigation, No. 03-17000, MDL 1535, N.D. Ohio; See 1/22/13, Page 35). (Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News)
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - April 13, 2013 Category: Medical Law Source Type: news

Property Damage Claims For Manganese Contamination Removed To Ohio Federal Court
TOLEDO, Ohio - The claims of more than 400 plaintiffs joined in a manganese exposure personal injury and property damage action were removed Jan. 18 to the U.S. District Court for the Northern District of Ohio; the steel mill owner defendant was granted in a Feb. 4 marginal order until March 7 to file an answer to the complaint (Michael F. Abrams, et al. v. Nucor Steel Marion Inc., No. 13-137, N.D. Ohio). (Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News)
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - February 21, 2013 Category: Medical Law Source Type: news