Fight Aging! Newsletter, December 20th 2021

In conclusion, the low dose, prolonged angiotensin II exposure is associated with the induction of senescence in kidneys and the promotion of an inflammatory microenvironment through both secreted factors and immune cells. Endothelial cells appear to be a major cell type impacted. The elimination of senescent cells in the INK-ATTAC transgenic model prevents these effects of angiotensin II and reveals a novel pathophysiologic mechanism amenable to targeting by senolytic drugs in development. CYTOR Upregulation as a Path to Improved Muscle Function in Later Life https://www.fightaging.org/archives/2021/12/cytor-upregulation-as-a-path-to-improved-muscle-function-in-later-life/ Researchers here report on their investigation of the role of the long noncoding RNA CYTOR, involved in muscle function, and which declines in expression with age. As a class, long noncoding RNAs are comparatively poorly explored, and many, such as CYTOR, appear to participate in numerous critical cell functions, touching on structure, growth, and migration. Concretely, however, it seems that CYTOR is a potential target to improve muscle function in later life, and the work here shows that it can be upregulated to beneficial effect in mice via gene therapy strategies without immediately obvious side-effects. Skeletal muscle displays remarkable plasticity upon exercise and is also one of the organs most affected by aging. Despite robust evidence that aging is associated with los...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs