Fight Aging! Newsletter, February 18th 2019

This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships between fundamental aging processes and ARDs are still missing. It could also be that the above-mentioned fundamental aging processes themselves are mediated by positive feedback loops. For example, chronic inflammation can amplify itself similarly to autoimmune diseases via cytokines and epitope spreading. Cellular senescence can propagate from cell to cell in a chain-reaction fashion via cytokines and reactive oxygen species. DNA damage may amplify by affecting the genes of more and more DNA repair enzymes. Accumulating intracellular garbage may impair the lysososmal function, leading to ever-accelerating garbage accumulation. However, to test these propositions, longitudinal data on the kinetics of corresponding processes should be obtained. Trends in Human Mortality in Very Late Life May be Illusions Resulting from Bad Data https://ww...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

Related Links:

Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Fahd M. Abdelkarem, Ezz-Eldin K. Desoky, Alaa M. Nafady, Ahmed E. Allam, Aldoushy Mahdy, Maki Nagata, Tomofumi Miyamoto, Kuniyoshi ShimizuAbstractFurther chemical study of the crude extract of the soft coral Heteroxenia fuscescens (Fam., Xeniidea), led to isolation of two new sterols, Heterofuscesterols A (1) and B (2), a sterol isolated for the first time from natural sources, 3β,5α,6β-trihydroxyandrosta-17-one (3), along with one new hydroperoxy sesquiterpene, Heterofusceterpene A (4), and one known ceramide (5). Their structu...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
Publication date: June 2020Source: Microchemical Journal, Volume 155Author(s): Karolina Nowak, Marcin Zawadzki, Tomasz JurekAbstractPostmortem diagnosis of hyperglycaemia is a challenge in forensic medicine. Glycated haemoglobin (HbA1c) is considered one of the markers providing an alternative to postmortem determinations of glucose concentration. On the other hand, glycated albumin (GA) may be determined in cases of difficulty in determining HbA1c.The aim of this study was to implement and evaluate the usefulness of methods enabling determination of HbA1c an GA in postmortem material (HbA1c–peripheral blood, GA&ndas...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: June 2020Source: Microchemical Journal, Volume 155Author(s): David S.M. Ribeiro, Rafael C. Castro, José X. Soares, João L.M. SantosAbstractIn this work, the ability of thiomalic acid (TMA)-capped AgInS2 quantum dots to generate reactive oxygen species (ROS) upon irradiation with visible light was investigated, which led to the subsequent development of a luminol-based chemiluminometric method for the monitoring of melatonin (MLT) in commercial dietary supplements. The developed approach was based on the antioxidant properties of melatonin conferred by the electron-rich aromatic indole ring w...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: June 2020Source: Microchemical Journal, Volume 155Author(s): Ferenc T. Pastor, Dejan M. Šegan, Stanislava Ž. Gorjanović, Ana M. Kalušević, Desanka Ž. SužnjevićAbstractNumerous methods have been developed for determination of antioxidant (AO) activity in vitro, but only several spectrophotometrical assays are frequently applied. Among them, probably the most simple is FRAP assay, based on the reduction of Fe(III) to Fe(II) by antioxidants. In this work the applicability of that reaction for the development of electrochemical method for AO activity determination was examined. The two com...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: Available online 20 February 2020Source: Journal of Analytical and Applied PyrolysisAuthor(s): Jorge Reyes-Rivera, Eloy Solano, Teresa Terrazas, Marcos Soto-Hernández, Salvador Arias, Yara C. Almanza-Arjona, Luis A. Polindara-GarcíaABSTRACTPyrolysis coupled to gas chromatography and mass spectrometry (Py-GC/MS) is a fast analytical technique used to characterize different lignocellulosic materials. Additionally, cheminformatics allows processing the vast amount of information obtained from Py-GC/MS for the classification of such materials. Here we characterized the lignocellulosic matrix of ...
Source: Journal of Analytical and Applied Pyrolysis - Category: Chemistry Source Type: research
Publication date: Available online 21 February 2020Source: Chemical Engineering JournalAuthor(s): Meitong Ou, Chao Pan, Yongkang Yu, Xuan Wang, Yun Zhou, Hanjie Zhang, Qinzhen Cheng, Meiying Wu, Xiaoyuan Ji, Lin MeiAbstractExcessive reactive oxygen species (ROS), as effective cancer therapeutic agents, can promote tumor apoptosis. However, the clinical applications of ROS-mediated cancer therapies still have many limitations, such as self-defects of traditional photosensitizer, adverse tumor microenvironment (TME), and insufficient ROS production. Here, two-dimensional and highly oxidized ilmenite nanosheets (HOIL NSs, for...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 21 February 2020Source: Chemical Engineering JournalAuthor(s): Yang Zhang, Yanjun Xu, Di Sun, Zheying Meng, Weiwei Ying, Wei Gao, Rui Hou, Yuanyi Zheng, Xiaojun Cai, Bing Hu, Xianfang LinAbstractAs a promising treatment modality with spatial and temporal control, alternating magnetic field (AMF) triggered magnetic hyperthermal therapy (MHT) shows broad and promising applications to overcome the drawbacks of traditional focal therapies in combating cancer. However, the MHT efficacy is still not satisfactory with the presence of heat shock proteins (HSPs). In addition, sustained tumor hypox...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: 1 June 2020Source: Chemical Engineering Journal, Volume 389Author(s): Alsayed Mostafa, Seongwon Im, Mo-Kwon Lee, Young-Chae Song, Dong-Hoon KimAbstractIn the present work, effects of direct interspecies electron transfer (DIET)-promoting condition on anaerobic treatment of phenol, in up-flow anaerobic sludge blanket reactors (UASB) were investigated. One reactor (C-UASB) was operated as a control, while two reactors (EA-UASBs) were operated with electrical energy input (EEI) at 0.3 V and 0.6 V. The organic loading rate was gradually increased from 0.5 to 14 kg COD/m3/d at a fixed hydraulic ...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
In this study, the anti-aging... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Photochem. Photobiol. Sci. latest articles - Category: Chemistry Authors: Source Type: research
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Jeffrey D. Einkauf, Jonathan D. Burns To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
More News: Academies | Alzheimer's | Amnesia | Antidoxidants | Ataxia | Australia Health | Autoimmune Disease | Biochemistry | Biology | Biotechnology | Bladder Cancer | Brain | Brain Cancers | Burns | Canada Health | Cancer | Cancer & Oncology | Cancer Therapy | Carbohydrates | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Chemistry | Chemotherapy | Child Abuse | Child Development | Children | Clinical Trials | Conferences | Dermatology | Diabetes | Diabetes Mellitus | Diabetes Type 1 | Diabetes Type 2 | Diets | Eating Disorders & Weight Management | Education | Endocrinology | Environmental Health | Epidemiology | Epithelial Cancer | Gastroschisis Repair | Gene Therapy | Genetics | Geriatrics | Heart | Heart Attack | Heart Disease | Heart Failure | Heart Transplant | HIV AIDS | Hypertension | Insect Bites & Stings | Insulin | Kidney Transplant | Kidney Transplantation | Laboratory Medicine | Learning | Meat | Medical Ethics | Men | Mitochondrial Disease | Molecular Biology | Myelodysplastic Syndrome | Neurology | Neuroscience | Neurosurgery | Nutrition | Obesity | Pancreas | Pancreatic Cancer | Parasitic Diseases | Parasitology | Parkinson's Disease | Pregnancy | Research | Science | Skin | Statistics | Stem Cell Therapy | Stem Cells | Stroke | Study | Substance Abuse | Sugar | Toxicology | Transplant Surgery | Transplants | Universities & Medical Training | Ureter and Renal Pelvis Cancer | Urology & Nephrology | Weight Loss