Fight Aging! Newsletter, February 18th 2019

This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships between fundamental aging processes and ARDs are still missing. It could also be that the above-mentioned fundamental aging processes themselves are mediated by positive feedback loops. For example, chronic inflammation can amplify itself similarly to autoimmune diseases via cytokines and epitope spreading. Cellular senescence can propagate from cell to cell in a chain-reaction fashion via cytokines and reactive oxygen species. DNA damage may amplify by affecting the genes of more and more DNA repair enzymes. Accumulating intracellular garbage may impair the lysososmal function, leading to ever-accelerating garbage accumulation. However, to test these propositions, longitudinal data on the kinetics of corresponding processes should be obtained. Trends in Human Mortality in Very Late Life May be Illusions Resulting from Bad Data https://ww...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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This study compared the effects of different dietary energy contents (11.3, 12.0 and 12.7 MJ ME/ kg feed) fed ad libitum in a feedlot on the carcass quality characteristics (carcass yield, commercial yield, 3-rib cut) of goats introduced to feedlot at 22.2 ± 3.5 kg (18 weeks of age), and slaughtered at five week intervals. The energy content of the finisher diets had no effect (P > 0.05) on any of the traits measured. However, the time spent in the feedlot influenced (P 
Source: Small Ruminant Research - Category: Zoology Source Type: research
In this study, MHC-1 and PDL-1 score in primary and metastatic tumor cells was evaluated in 43 gastric cancer patients with lymph node metastasis. According to our results, the primary tumor PDL-1 score was correlated with the number of metastatic lymph nodes (r = 0.258; p = 0.024) and primary tumor size (r = 0.341; p = 0.045). A similar correlation was found between the primary tumor PDL-1 score and the metastatic tumor PDL-1 score (r = 0.213; p = 0.015). In our study, MHC-1 was found to be higher in primary tumors than metastatic tumors, although not statistically significant (p = 0.054). The results of our study showed ...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Authors: McCarthy AJ, O'Reilly SM, Shanley J, Geraghty R, Ryan EJ, Cullen G, Sheahan K Abstract Background: As the malignant potential of sessile serrated lesions/polyps (SSL/Ps) and traditional serrated adenomas (TSAs) has been clearly demonstrated, it is important that serrated polyps are identified and correctly classified histologically. Aim: Our aim was to characterize the clinicopathological features of a series of SSL/Ps &TSAs, to assess the accuracy of the pathological diagnosis, the incidence, and the rate of dysplasia in SSL/Ps &TSAs. Methods: We identified all colorectal serrated polyps b...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Publication date: Available online 18 March 2019Source: Veterinary ParasitologyAuthor(s): Dave M. Leathwick, Christian W. Sauermann, Craig R. Reinemeyer, Martin K. NielsenAbstractA model was developed to reproduce the dynamics of the parasitic stages of equine cyathostomins. Based on a detailed review of published literature, a deterministic simulation model was constructed using the escalator box-train approach, which allows for fully-overlapping cohorts of worms and approximately normally distributed variations in age/size classes. Key biological features include a declining establishment of ingested infective stage larv...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
CONCLUSION: The described tunneling flap approach allows a hermetic soft tissue closure, characterized by a reduction of dehiscence and a secure bone graft healing. The combination of thin autogenous bone blocks and bone particles according to the SBB technique allows an acceleration of transplant revascularization, and thus, of graft regeneration, allowing a shortening of the patient treatment time as well as long-term three-dimensional volumetric bone stability. PMID: 30883623 [PubMed - in process]
Source: International Journal of Oral and Maxillofacial Implants - Category: ENT & OMF Tags: Int J Oral Maxillofac Implants Source Type: research
Authors: Sartori EM, das Neves AM, Magro-Filho O, Mendonça DBS, Krebsbach PH, Cooper LF, Mendonça G Abstract Regulation of cellular function is key to bone formation at endosseous implant surfaces. Osseointegration was "discovered" prior to the discovery of genetic regulation of osteoinduction or characterization of mesenchymal stem cells. Understanding osseointegration in cellular and molecular terms has benefited from genome-wide characterization of this healing process at endosseous implants in vivo. These in vivo studies also demonstrate a role for osteoprogenitor cells and cells involve...
Source: International Journal of Oral and Maxillofacial Implants - Category: ENT & OMF Tags: Int J Oral Maxillofac Implants Source Type: research
Publication date: Available online 7 March 2019Source: Physics Letters AAuthor(s): Wenpo Yao, Wenli Yao, Jun WangAbstractThe association of equal heartbeat intervals with cardiac conditions and the effect of the equality on permutation-based time irreversibility are investigated in this paper. We measure the distributions of equal heartbeat intervals under three conditions, namely congestive heart failure (CHF), healthy young and elderly, whose time irreversibility is detected by measuring the probabilistic difference between permutations instead of raw vectors. We demonstrate that heartbeats contain high rates of equal st...
Source: Physics Letters A - Category: Physics Source Type: research
Claudio de Lucia, Celestino Sardu, Laurent Metzinger, Coert J. Zuurbier
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Publication date: Available online 18 March 2019Source: Molecular Aspects of MedicineAuthor(s): Laura Valle, Richarda M. de Voer, Yael Goldberg, Wenche Sjursen, Asta Försti, Clara Ruiz-Ponte, Trinidad Caldés, Pilar Garré, Maren F. Olsen, Margareta Nordling, Sergi Castellvi-Bel, Kari HemminkiAbstractThe present article summarizes recent developments in the characterization of genetic predisposition to colorectal cancer (CRC). The main themes covered include new hereditary CRC and polyposis syndromes, non-CRC hereditary cancer genes found mutated in CRC patients, strategies used to identify novel causal ge...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
Publication date: Available online 18 March 2019Source: Journal of Molecular StructureAuthor(s): S. Aayisha, T.S. Renuga Devi, S. Janani, S. Muthu, M. Raja, S. SevvanthiAbstractA molecule 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine plays a significant role in the treatment of hypertension and acts as a potential I 1 imidazoline receptor agonist. In this present work, the molecular structure of the title compound has been investigated using experimental (FT-IR, FT-Raman and NMR) and theoretical (DFT) techniques. R2 values of FR-IR, FT-Raman and bond lengths state the coherence between theor...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
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