Fight Aging! Newsletter, November 20th 2017

This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senescent cells, compared to controls with low titers. Importantly, we found that the effect of ELA on immunosenescence was associated with CMV infection specifically, rather than being the consequence of continued reactivation of latent viruses in general. Our findings have important implications for this literature on senescence in ELA. Most evidence for accelerated immunosenescence in ELA comes from telomere length, but none of these studies have accounted for CMV infections. Our results suggest that the association between ELA and shorter telomeres - or immunosenescence in general - may have been largely mediated by CMV infection. First of all, because there is a clear link between CMV infection and immunosenescence. CMV infection is related to expanding populations of specific memory T cells, and a shrinking population of naïve T cells, similar t...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Publication date: Available online 20 October 2018Source: Journal of Molecular Graphics and ModellingAuthor(s): Süleyman Selim Çınaroğlu, Emel TimuçinAbstractReplication Protein A (RPA) mediates DNA Damage Response (DDR) pathways through protein-protein interactions (PPIs). Targeting the PPIs formed between RPA and other DNA Damage Response (DDR) mediators has become an intriguing area of research for cancer drug discovery. A number of studies applied different methods ranging from high throughput screening approaches to fragment-based drug design tools to discover RPA inhibitors. Although these method...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
This study suggests that antidepressant-like effect of hesperidin may be mediated, at least in part, by decreased neuroinflammation and oxidative damage, and enhanced BDNF production in the hippocampus.
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 21 October 2018Source: Journal of Theoretical BiologyAuthor(s): Claude Gérard, Didier Gonze, Albert GoldbeterAbstractA network of cyclin-dependent kinases (Cdks) regulated by multiple negative and positive feedback loops controls progression in the mammalian cell cycle. We previously proposed a detailed computational model for this network, which consists of four coupled Cdk modules. Both this detailed model and a reduced, skeleton version show that the Cdk network is capable of temporal self-organization in the form of sustained Cdk oscillations, which correspond to the orderly pr...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Publication date: 20 October 2018Source: New Scientist, Volume 240, Issue 3200Author(s): Clare Wilson
Source: New Scientist - Category: Science Source Type: research
This study should increase our concern regarding the dispersal of ZnO NPs in aquatic environments.
Source: Aquatic Toxicology - Category: Toxicology Source Type: research
Publication date: Available online 21 October 2018Source: American Journal of Preventive MedicineAuthor(s): Soham Gupta, Alexander P. Cole, Maya Marchese, Ye Wang, Jacqueline M. Speed, Sean A. Fletcher, Junaid Nabi, Sebastian Berg, Stuart R. Lipsitz, Toni K. Choueiri, Steven L. Chang, Adam S. Kibel, Annemarie Uhlig, Quoc-Dien TrinhIntroductionWith improvements in early detection and treatment, a growing proportion of the population now lives with a personal history of a cancer. Although many cancer survivors are in excellent health, the underlying risk factors and side effects of cancer treatment increase the risk of medic...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionsAlthough increasing, the rate of GP referral to exercise physiologists was low and associated with patient and GP characteristics. Education of GPs about the role of exercise physiologists in the prevention and management of chronic diseaseconditions is needed.
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
Whole-breast radiation therapy can significantly lower the risk of recurrent...Read more on AuntMinnie.comRelated Reading: Can dedicated breast PET identify suspicious lesions? Women still need breast imaging after mastectomy Is radiation therapy warranted for DCIS postlumpectomy? Microbubbles improve breast cancer radiation therapy ASTRO: Short radiation course safe for breast cancer
Source: Headlines - Category: Radiology Source Type: news
Publication date: November 2018Source: Journal of Comparative Pathology, Volume 165Author(s): M.P. Dagleish, J.J. Clark, C. Robson, M. Tucker, R.J. Orton, M.S. RocchiSummaryLouping-ill (LI), caused by louping-ill virus (LIV), results in a frequently fatal encephalitis primarily affecting sheep and red grouse (Lagopus lagopus scotica), but it does occur in other species. An adult male Border collie dog was definitively diagnosed with fatal LI and the lesion profile, LIV antigen distribution and full genome sequence of the LIV responsible were investigated to determine if this differed significantly from sheep-derived LIV. N...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
Publication date: November–December 2018Source: Spine Deformity, Volume 6, Issue 6Author(s): Jun S. Kim, Varun Arvind, Eric K. Oermann, Deepak Kaji, Will Ranson, Chierika Ukogu, Awais K. Hussain, John Caridi, Samuel K. ChoAbstractStudy DesignCross-sectional database study.ObjectiveTo train and validate machine learning models to identify risk factors for complications following surgery for adult spinal deformity (ASD).Summary of Background DataMachine learning models such as logistic regression (LR) and artificial neural networks (ANNs) are valuable tools for analyzing and interpreting large and complex data sets. AN...
Source: Spine Deformity - Category: Orthopaedics Source Type: research
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