Fight Aging! Newsletter, November 20th 2017

This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senescent cells, compared to controls with low titers. Importantly, we found that the effect of ELA on immunosenescence was associated with CMV infection specifically, rather than being the consequence of continued reactivation of latent viruses in general. Our findings have important implications for this literature on senescence in ELA. Most evidence for accelerated immunosenescence in ELA comes from telomere length, but none of these studies have accounted for CMV infections. Our results suggest that the association between ELA and shorter telomeres - or immunosenescence in general - may have been largely mediated by CMV infection. First of all, because there is a clear link between CMV infection and immunosenescence. CMV infection is related to expanding populations of specific memory T cells, and a shrinking population of naïve T cells, similar t...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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CONCLUSION: The present findings show that Aβ and tau are differently affected in the chronic phase of severe TBI. PMID: 29792528 [PubMed - as supplied by publisher]
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One of the fundamental distinctions we need to make when working with people who experience pain is to understand the difference between experiencing pain – and the behaviour or actions or responses we make to this experience. This is crucial because we can never know “what it is like” to experience pain – and all we have to rely on as external observers is what we see the person doing. Differentiating between the various dimensions associated with our experience of pain makes it far easier to address each part in the distinct ways needed. Let me explain. We know the current definition of pain &ndas...
Source: HealthSkills Weblog - Category: Anesthesiology Authors: Tags: Clinical reasoning Cognitive skills Education/CME Pain Pain conditions biopsychosocial disability Research theory Source Type: blogs
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
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(MedPage Today) -- San Diego operator now under investigation by his affiliated hospital
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It is needless to say that heart disease in pregnancy is a challenge for the obstetrician and the cardiologist. Hemodynamic changes in pregnancy and labour can adversely affect many of the significant cardiac lesions. Increase in blood volume and heart rate are the important factors during pregnancy. In general stenotic lesions and pulmonary hypertension are poorly tolerated, while regurgitant lesions are better tolerated. Specific risks like aortic dissection and rupture are there for coarctation of aorta. Several risk stratification schemes have been developed for assessing the risk of pregnancy with heart disease over ...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology CARPREG II risk scoring CARPREG risk stratification mWHO classification ZAHARA risk score Source Type: blogs
Source: NanoFocus - Category: Nanotechnology Authors: Source Type: research
ARTHRITIS symptoms consist of joint stiffness, pain and swelling, among others. Types of the condition include rheumatoid arthritis, psoriatic arthritis and osteoarthritis. You ’re more likely to develop the condition if you’re older, overweight or have a previous injury. This joint exercise can help treat the symptoms.
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Our weekly series of diabetes humor at DiabetesMine features a cartoon by Jerry King.
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CONCLUSIONS: In the head and neck area, the double tie-over dressing required less time to heal than the simple bolster dressing. PMID: 29788688 [PubMed]
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