Doppler-defined pulmonary hypertension in sepsis and septic shock
The authors of this study state that the association of pulmonary hypertension (PH) in patients with sepsis is lesser understood. In patients with sepsis and septic shock, PH is common and is noted to be associated with higher short and long-term mortality. Further studies are needed to understand the mechanisms by which PH is associated with outcomes. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 17, 2019 Category: Consumer Health News Source Type: news

Sepsis: Early Recognition and Optimized Treatment
The authors of this article state that sepsis is a life-threatening condition caused by infection and represents a substantial global health burden. Recent epidemiological studies showed that sepsis mortality rates have decreased, but that the incidence has continued to increase. Although a mortality benefit from early-goal directed therapy (EGDT) in patients with severe sepsis or septic shock was reported in 2001, three subsequent multicenter randomized studies showed no benefits of EGDT versus usual care. Nonetheless, the early administration of antibiotics and intravenous fluids is considered crucial for the treatment o...
Source: Current Awareness Service for Health (CASH) - January 17, 2019 Category: Consumer Health News Source Type: news

A Retrospective Review of the Sepsis Definition after Publication of Sepsis-3
The authors of this review article state that two and a half years after the introduction of Sepsis-3, clinicians continue not to document Sequential Organ Failure Assessment (SOFA) scores. The purpose of the review is to determine if the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) were being utilized in defining sepsis in the clinical setting. There continue to be variations in what standard is accepted by both commercial payers and the Centers for Medicare and Medicaid (CMS) in diagnosing sepsis. Due to Sepsis-3 criteria not being accepted by CMS or the Infectious Disease Society of A...
Source: Current Awareness Service for Health (CASH) - January 17, 2019 Category: Consumer Health News Source Type: news

Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study
The authors of this journal article state that adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, they assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled ...
Source: Current Awareness Service for Health (CASH) - January 17, 2019 Category: Consumer Health News Source Type: news

Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock
This Review says that based on data from 3 paediatric RCTs (n=3402), liberal fluid therapy might increase mortality among children with sepsis or septic shock in hospital and at four ‐week follow‐up. Trials including adults, and patients with a broader spectrum of pathogens are needed. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 16, 2019 Category: Consumer Health News Source Type: news

Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or septic shock
This Cochrane Review was Substantively amended in January 2019. However, there was no change to the conclusion, that Up-to-date evidence of very low to moderate quality, with insufficient sample power per outcome, does not clearly support the use of procalcitonin-guided antimicrobial therapy to minimize mortality, mechanical ventilation, clinical severity, reinfection or duration of antimicrobial therapy of patients with septic conditions. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 11, 2019 Category: Consumer Health News Source Type: news

Sepsis | Medscape Sepsis | Medscape
Review clinical reference information, guidelines, and medical news on sepsis, including identification of sepsis blood infection and septic shock. Review guidelines on SIRS sepsis, Candida sepsis, MRSA sepsis, and pneumococcal sepsis. (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 4, 2019 Category: Consumer Health News Tags: Resource Center Source Type: news

Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid
The authors of this journal article state that sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. They say that over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid and Thiamine (HAT therapy) may reduce organ failure and mortality in patients with sepsis and septic shock. HAT therapy is based on the concept that a combination of readily available, safe and cheap agents, which target multiple components of the host's r...
Source: Current Awareness Service for Health (CASH) - December 28, 2018 Category: Consumer Health News Source Type: news

Prompt admission to intensive care is associated with improved survival in patients with severe sepsis and/or septic shock
This research article aims to investigate the association between time from hospital admission to intensive care unit (ICU) admission (door to ICU time) and hospital mortality in patients with sepsis. A shorter time from hospital door to ICU admission was shown to be independently associated with reduced hospital mortality in patients with severe sepsis and/or septic shock. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 28, 2018 Category: Consumer Health News Source Type: news

Emerging Adjunctive Approach for the Treatment of Sepsis: Vitamin C and Thiamine.
The authors of this journal article say that evidence is emerging that parenteral administration of high-dose vitamin C and thiamine may be a beneficial adjuvant therapy of severe sepsis and septic shock. Despite modern practices in critical care medicine, sepsis and severe sepsis remain a leading cause of morbidity and mortality in the critical care unit. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 28, 2018 Category: Consumer Health News Source Type: news

The use of procalcitonin in the determination of severity of sepsis, patient outcomes and infection characteristics
The primary objective of this study was to determine the correlation between procalcitonin values and illness severity by evaluating the degree of end organ dysfunction using the Sequential Organ Failure Assessment score, length of stay and the severity of sepsis (sepsis alone vs. septic shock), The hypothesis that procalcitonin values would be higher in sicker patients was formulated before data collection began. Secondary outcomes studied in relation to procalcitonin levels included infection characteristics such as the site of infection, microbial agent and dialysis dependent CKD. Procalcitonin has a higher specificity ...
Source: Current Awareness Service for Health (CASH) - December 28, 2018 Category: Consumer Health News Source Type: news

De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock
This review concludes that there is no adequate, direct evidence as to whether de-escalation of antimicrobial agents is effective and safe for adults with sepsis, severe sepsis or septic shock. The authors say this uncertainty warrants further research via RCTs and the authors are awaiting the results of an ongoing RCT testing the de-escalation of empirical antimicrobial therapy for severe sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 28, 2018 Category: Consumer Health News Source Type: news

Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock
This review concludes low ‐ to high‐quality evidence shows that liberal fluid therapy may increase the death rate for children with sepsis or septic shock. Except for this finding, the authors are uncertain about the effects of liberal versus conservative fluid therapy on the risk of adverse events. They are also uncerta in about the effects of these two interventions for adults with sepsis or septic shock due to lack of data. Future trials focusing on adult sepsis or septic shock in other settings, with a wider range of pathogens, are expected. The authors say that once published and assessed, the three'ongoing'studie...
Source: Current Awareness Service for Health (CASH) - December 19, 2018 Category: Consumer Health News Source Type: news

Mayo Clinic Q and A: Understanding sepsis and septic shock
DEAR MAYO CLINIC:?Who?s most at risk for developing sepsis, and what are the symptoms to watch for? What?s the difference between sepsis and septic shock? ANSWER:?Sepsis?is a serious complication of an infection. It often triggers various symptoms, including high fever, elevated heart rate and fast breathing. If sepsis goes unchecked, it can progress to septic [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - December 7, 2018 Category: Databases & Libraries Source Type: news

Diagnostics Are Helping Counter Antimicrobial Resistance, But More Work Is Needed
Antimicrobial resistance (AMR) threats to patient health are becoming more widely recognized and diagnostics manufacturers are making significant progress in combatting the overuse of antibiotics. There is still a lot of work to be done, however. A recent health scare for Rick Bright, Ph.D., director of the Biomedical Advanced Research and Development Authority (BARDA), HHS, the very agency working to combat emerging infectious diseases (EID) and other threats, highlights the lingering risks.  During the 10th Public Meeting of the Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB...
Source: MDDI - November 20, 2018 Category: Medical Devices Authors: Daphne Allen Tags: IVD Source Type: news

Current Management of Gram-Negative Septic Shock Current Management of Gram-Negative Septic Shock
Septic shock is a potentially life-threatening condition, and its management can be challenging. How are Gram-negative infections best treated?Current Opinion in Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 19, 2018 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation
This review states that the combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and septic shock. In the present manuscript, the authors provide a comprehensive review of the pathophysiologic basis and supporting research for each element of the thiamine, ascorbic acid, and hydrocortisone drug combination in sepsis. In addition, they describe potential areas of synergy between these therapies and discuss the strengths/weaknesses of the two studies to date which have evaluated...
Source: Current Awareness Service for Health (CASH) - November 16, 2018 Category: Consumer Health News Source Type: news

Transcriptomic Signatures in Sepsis and a Differential Response to Steroids: From the VANISH Randomized Trial
This research article states that there remains uncertainty about the role of corticosteroids in sepsis with clear beneficial effects on shock duration but conflicting survival effects. Two transcriptomic sepsis response signatures (SRS) have been identified. SRS1 is relatively immunosuppressed whilst SRS2 is relatively immunocompetent. The Transcriptomic profile at onset of septic shock was associated with response to corticosteroids. The study concludes that those with the immuno-competent SRS2 endotype had significantly higher mortality when given corticosteroids compared to placebo. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 16, 2018 Category: Consumer Health News Source Type: news

Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis
This research article states that acute kidney injury is the most frequent complication in patients with septic shock and is an independent risk factor for death. The authors say that although renal-replacement therapy is the standard of care for severe acute kidney injury, the ideal time for initiation remains controversial. The study found that among patients with septic shock who had severe acute kidney injury, there was no significant difference in overall mortality at 90 days between patients who were assigned to an early strategy for the initiation of renal-replacement therapy and those who were assigned to a delayed...
Source: Current Awareness Service for Health (CASH) - November 16, 2018 Category: Consumer Health News Source Type: news

Antibiotics for Sepsis-Finding the Equilibrium
This journal article describes sepsis is medicine's last remaining preserve for unrestrained antibiotic prescribing. The Surviving Sepsis Campaign guidelines recommend empirical broad-spectrum therapy within one hour of triage for both sepsis and septic shock.1 This recommendation, and mandates that compel it, encourage clinicians to adopt an approach of “treat first, ask questions later” for patients with any possibility of serious infection. The authors state that this approach fails to account for the difficulties clinicians face with diagnosing infection, especially when patients initially present to care, ...
Source: Current Awareness Service for Health (CASH) - November 15, 2018 Category: Consumer Health News Source Type: news

Oregon researchers discover novel anti-inflammatory bacterial protein
(University of Oregon) Researchers at the University of Oregon have identified a novel protein secreted by a common gut bacterium in zebrafish that reduces inflammation in the gut and delays death by septic shock. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 6, 2018 Category: Biology Source Type: news

Derivation of a screen to identify severe sepsis and septic shock in the Emergency Department-BOMBARD vs. SIRS and qSOFA
This study looks to predict severe sepsis/septic shock in ED patients. The authors conducted a retrospective case-control study of patients ≥18 admitted to two urban hospitals with a combined ED census of 162,000. Study cases included patients with severe sepsis/septic shock admitted via the ED. Controls comprised admissions without severe sepsis/septic shock. Using multivariate logistic regression, a prediction rule was const ructed - BOMBARD. The model's AUROC was internally validated using 1000 bootstrap samples. BOMBARD was more accurate than SIRS and qSOFA at predicting severe sepsis/septic shock and sepsis mortali...
Source: Current Awareness Service for Health (CASH) - October 19, 2018 Category: Consumer Health News Source Type: news

P(v-a)CO2/C(a-v)O2-directed resuscitation does not improve prognosis compared with SvO2 in severe sepsis and septic shock: A prospective multicenter randomized controlled clinical study
This study examined the value of P(v-a)CO2/C(a-v)O2 compared with ScvO2 as a target for clinical resuscitation of severe sepsis/septic shock. P(v-a)CO2/C(a-v)O2-directed resuscitation did not improve prognosis compared with ScvO2 in severe sepsis and septic shock. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 19, 2018 Category: Consumer Health News Source Type: news

Early Dialysis Not Better for Septic Shock Patients With Acute Kidney Injury Early Dialysis Not Better for Septic Shock Patients With Acute Kidney Injury
Early renal-replacement therapy for patients in the initial phase of septic shock who have severe acute kidney injury is no better than delayed therapy, according to a French study of 488 patients that was stopped early for futility.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - October 12, 2018 Category: Intensive Care Tags: Nephrology News Source Type: news

Is Kidney Dialysis Always Needed When Septic Shock Strikes?
Title: Is Kidney Dialysis Always Needed When Septic Shock Strikes?Category: Health NewsCreated: 10/10/2018 12:00:00 AMLast Editorial Review: 10/11/2018 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - October 11, 2018 Category: Nutrition Source Type: news

Renal-Replacement Timing Has No Effect in Kidney Injury, Sepsis
WEDNESDAY, Oct. 10, 2018 -- For patients with early-stage septic shock and severe acute kidney injury, 90-day mortality does not differ for patients randomly assigned to an early strategy for initiation of renal-replacement therapy versus a delayed... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 10, 2018 Category: Pharmaceuticals Source Type: news

Is Kidney Dialysis Always Needed When Septic Shock Strikes?
WEDNESDAY, Oct. 10, 2018 -- When serious infection gives rise to septic shock, the resulting plunge in blood pressure can cripple kidney function, necessitating immediate dialysis. But clinicians know that not all patients need it, because in the... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 10, 2018 Category: General Medicine Source Type: news

Sepsis Bundle Adherence Is Associated with Improved Survival in Severe Sepsis or Septic Shock
This research article outlines how there have been conflicting data regarding the relationship between sepsis-bundle adherence and mortality. Moreover, little is known about how this relationship may be moderated by the anatomic source of infection or the location of sepsis declaration. In a large public healthcare system, adherence with severe sepsis/septic shock management bundles was found to be associated with improved survival. The study concluded that bundle adherence seems to be most beneficial for patients with pneumonia. The overall improved survival in patients who received bundle-adherent care was driven by pati...
Source: Current Awareness Service for Health (CASH) - September 29, 2018 Category: Consumer Health News Source Type: news

Importance of Markers of Sepsis in Surgical Patients
This journal article examines how sepsis, severe sepsis, and septic shock represent a serious medicinal and general social problem and still maintain an important position among the present issues in the basic and clinical research. In the prospective analysis of patients satisfying the criteria of septic condition, the authors determined serum levels of bioparameters in three consecutive days from the first signs of sepsis depending on the stage or advancement of the septic condition. They determined the most significant parameter/parameters which are able to determine the stage of sepsis or to predict patient's death. Th...
Source: Current Awareness Service for Health (CASH) - September 28, 2018 Category: Consumer Health News Source Type: news

Corticosteroid therapy for sepsis: a clinical practice guideline
This rapid recommendation looks at whether corticosteroids reduce death or improve recovery in people with sepsis or septic shock. The panel make a weak recommendation to give corticosteroids to people with all types and severity of sepsis, based on new evidence. Because they are not certain that they are beneficial, it is also reasonable not to prescribe them. The authors state that patients'values and preferences may guide this decision-making process. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 28, 2018 Category: Consumer Health News Source Type: news

Trial by Fire: Critics Demand That a Huge Sepsis Study Be Stopped
A trial enrolling new patients resembles “ an experiment that would be conducted on laboratory animals, ” one advocacy group said. (Source: NYT Health)
Source: NYT Health - September 24, 2018 Category: Consumer Health News Authors: RONI CARYN RABIN Tags: Sepsis Blood Pressure Septic Shock Clinical Trials National Institutes of Health Source Type: news

Vitamin C therapy delivers astounding results to septic shock patients
(Natural News) When you hear something being deemed a “miracle cure,” it’s normal to dismiss it as hype. It often turns out that someone is just trying to sell you something or exaggerating. In fact, this language is so common in internet click bait headlines that it can be hard to take such claims seriously.... (Source: NaturalNews.com)
Source: NaturalNews.com - September 16, 2018 Category: Consumer Health News Source Type: news

Argipressin: New therapy for septic shock now approved for 26 EU countries
(B&K - Bettschart&Kofler Kommunikationsberatung) A new therapeutic option for septic shock has now been approved for and is available in 26 European countries. Sepsis affects 27-30 million people and leads to eight million deaths worldwide every year. Septic shock is caused by a generalized bacterial infection and is associated with higher morbidity and mortality as well as extended invalidity. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 13, 2018 Category: International Medicine & Public Health Source Type: news

Mortality Measures to Profile Hospital Performance for Patients With Septic Shock
This research article concludes that risk-standardized septic shock mortality rates varied considerably between hospitals, suggesting that septic shock is an important performance target. However, efforts to profile hospital performance were sensitive to septic shock case definitions, suggesting that septic shock mortality is not currently ready for widespread use as a hospital quality measure (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 7, 2018 Category: Consumer Health News Source Type: news

CE: Managing Sepsis and Septic Shock Current Guidelines and Definitions
This article discusses the new SSC treatment guidelines, changes in the sepsis bundle interventions, and theSepsis-3 definitions and tools, all of which enable nurses to improve patient outcomes through timely collaborative action (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 7, 2018 Category: Consumer Health News Source Type: news

Mottling score and skin temperature in septic shock: Relation and impact on prognosis in ICU
This journal article concludes that skin temperature measured with infrared thermography technology around the knee is lower when mottling sign is present and sign microcirculation alterations. This method, compared to standard mottling score is objective and allows data collections. However, this method failed to predict mortality in ICU patients. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 7, 2018 Category: Consumer Health News Source Type: news

New York State sepsis reporting mandate appears to improve care, reduce deaths
(American Thoracic Society) A New York State requirement that all hospitals report compliance with protocols to treat severe sepsis and septic shock appears to improve care and reduce mortality from one of the most common causes of death in those who are critically ill, according to a new study published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 7, 2018 Category: International Medicine & Public Health Source Type: news

Pediatric Sepsis: A Primer for the Pediatrician
This journal article outlines how sepsis is the body's systemic response to infection and is a serious health care concern that affects neonatal, pediatric, and adult populations worldwide. Severe sepsis and septic shock are still associated with high mortality rates despite improvements in the management of infectious processes. The cellular processes that occur as a result of the inflammatory response in sepsis, including impaired perfusion and microcirculatory coagulation, can lead to organ system dysfunction. Early recognition of sepsis can help prompt treatment to improve patient care. Current pediatric guidelines emp...
Source: Current Awareness Service for Health (CASH) - July 19, 2018 Category: Consumer Health News Source Type: news

CE: Managing Sepsis and Septic Shock
This article discusses the new SSC treatment guidelines, changes in the sepsis bundle interventions, and the Sepsis-3 definitions and tools, all of which enable nurses to improve patient outcomes through timely collaborative action. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 19, 2018 Category: Consumer Health News Source Type: news

Transporting Patients to Appropriate Receiving Destinations
Conclusion EMS is in a position to be the initiator of specialty center destination. In large cities with multiple hospitals, EMS should transport patients to the closest, most appropriate facility based on patient condition, even if this requires passing a closer facility. Where there are hospitals with multiple specialty services, EMS may be asked to activate a specific team, such as the stroke or cardiac team. In rural communities, EMS can communicate with the local hospital and by letting the hospital know of patient condition, help start the interfacility transport process from the field....
Source: JEMS Special Topics - July 19, 2018 Category: Emergency Medicine Authors: Dennis Edgerly, MEd, EMT-P Tags: Exclusive Articles Columns Operations Source Type: news

Deadly Respiratory Distress Mimic
Conclusion It’s important for prehospital providers to be able to differentiate metabolic disturbances in the setting of respiratory distress and not be fooled into thinking tachypnea always has a respiratory cause. The physical exam and adjuncts such as end-tidal capnography can assist in the prehospital diagnosis. A COPD exacerbation generally presents as diminished lung sounds, wheezing on exhalation, and a prolonged expiratory phase. Here, a patient will attempt to compensate for the inflammation and mucus accumulation associated with the destruction and narrowing of peripheral airways and a subsequent lack of av...
Source: JEMS Special Topics - July 17, 2018 Category: Emergency Medicine Authors: Brenton Faber, PhD, NRP Tags: Airway & Respiratory Exclusive Articles Patient Care Source Type: news

Memphis doc takes on sepsis, earns $1.9M in funding
From 2003 to 2009, hospitalization for septic shock increased almost 50 percent and — with the condition having a 30 to 50 percent mortality rate — the math is … well, not great. Each year, about 210,000 people die of sepsis in the U.S. The condition is generally described as an incurable inflammatory response to an infection and, most often, occurs in people who have been h ospitalized. But, here is a better number: $1.9 million. Dr. Guoyun Chen, an assistant professor of pediatrics research… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - July 12, 2018 Category: Pharmaceuticals Authors: Mary Cashiola Source Type: news

The role of glucocorticoids as adjunctive treatment for sepsis in the modern era
This viewpoint critically appraises two large RCTs published this year investigating the role of hydrocortisone n patients with septic shock, which had conflicting results. It evaluates the use of glucocorticoids in the treatment of sepsis and septic shock in the modern era. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 12, 2018 Category: Consumer Health News Source Type: news

Surviving Sepsis Campaign: Research Priorities for Sepsis and Septic Shock
This journal article outlines how while the Surviving Sepsis Campaign guidelines give multiple recommendations on the treatment of sepsis, significant knowledge gaps remain, both in bedside issues directly applicable to clinicians, as well as understanding the fundamental mechanisms underlying the development and progression of sepsis. The priorities identified represent a roadmap for research in sepsis and septic shock. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 4, 2018 Category: Consumer Health News Source Type: news

Sepsis and septic shock
This Seminar presents up-to-date evidence and controversies about sepsis, and highlights the importance of driving quality improvement through initiatives such as the Surviving Sepsis Campaign. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 27, 2018 Category: Consumer Health News Source Type: news

Sepsis-3 criteria 'preferable' in prognostication of critically ill patients
(American College of Chest Physicians) Researchers from the University of Ottawa sought to compare the prognostic accuracy of the Sepsis-3 septic shock criteria with the SIRS-based septic shock criteria for prediction of in-hospital mortality among patients hospitalized with suspected infection, receiving a RRT assessment for acute deterioration. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 14, 2018 Category: International Medicine & Public Health Source Type: news

Sepsis 2018: Definitions and Guideline Changes
This review discusses new definitions for sepsis and septic shock. TheThird International Consensus Definitions for Sepsis and Septic Shock [Sepsis-3] have been developed. A new screening tool for sepsis (quick Sequential Organ Failure Assessment [qSOFA]) has been proposed to predict the likelihood of poor outcome in out-of-intensive care unit (ICU) patients with clinical suspicion of sepsis. The Surviving Sepsis Campaign Guidelines were recently updated and include greater evidence-based recommendations for treatment of sepsis in attempts to reduce sepsis-associated mortality. The review discusses the new Sepsis-3 definit...
Source: Current Awareness Service for Health (CASH) - June 13, 2018 Category: Consumer Health News Source Type: news

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
These updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsis or at risk of developing sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 13, 2018 Category: Consumer Health News Source Type: news

Early lactate measurements appear to improve results for septic patients
(University of Chicago Medical Center) The controversial Severe Sepsis and Septic Shock Early Management Bundle study adds weight to the belief that early lactate measurements can make a big difference. This follow-up study found a two percent increase in mortality for each hour of delay in patients with an abnormal lactate value. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 24, 2018 Category: Infectious Diseases Source Type: news

Early Goal-Directed Therapy in Severe Sepsis and Septic Shock: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials
This meta-analysis concludes that adults with severe sepsis and septic shock who received Early Goal-Directed Therapy had a lower mortality than those given usual care, the benefit may mainly be attributed to treatments administered within the first 6 hours. However, the underlying mechanisms by which lactate clearance-guided therapy benefits these patients are yet to be investigated. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 9, 2018 Category: Consumer Health News Source Type: news