Mesenchymal stromal cells for sepsis and septic shock: Lessons for treatment of COVID-19. Stem cells translational medicine 9(12): 1488-1494.
Sepsis is defined as life-threatening organ dysfunction caused by a deregulated immune host response to infection. The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted this multifactorial and complex syndrome. The absence of specific treatment neither against SARS-CoV-2 nor against acute respiratory distress syndrome (ARDS), the most serious stage of this infection, has emphasized the need to find alternative treatments. Several therapeutics are currently being tested, including mesenchymal stromal cells. These cells, already used in preclinical models of ARDS, sepsis, and septi...
Source: Current Awareness Service for Health (CASH) - January 8, 2021 Category: Consumer Health News Source Type: news

Resistant Infections in Emergency Department Patients with Suspected Sepsis. The American journal of the medical sciences 360(6): 650-655.
Background: Inappropriate antibiotic therapy in sepsis is associated with poor outcomes, clinicians often provide routine coverage for multidrug resistant (MDR) bacteria. However, these regimens may contribute to problems related to antibiotic overuse. To understand the incidence and related factors of multidrug resistant bacterial infections in ED patients with sepsis, we examined how often patients with sepsis in our emergency department had MDR infections. We also explored risk factors for, and outcomes from, MDR bacterial infections.; Methods: We reviewed records of patients presenting to our emergency department (ED) ...
Source: Current Awareness Service for Health (CASH) - January 8, 2021 Category: Consumer Health News Source Type: news

Approaches in Prehospital Sepsis Screening
Discussion In the United States, sepsis is one of the leading causes of death, which requires timely identification and proper treatment (CDC, 2019; Guerra et al., 2020; Polito et al., 2015). Based upon a review of literature conducted from 2014 to 2018, the primary investigators could locate five prehospital EMS screening tools to assist EMS providers in identifying at-risk sepsis patients. The researchers explored how the modified SIRS and qSOFA scoring systems were used in hospital settings in addition to these five prehospital EMS screening tools. The Bas 90-30-90, Guerra, PRESEP, PRESS, and Robson tools have ove...
Source: JEMS: Journal of Emergency Medical Services News - January 5, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives Patient Care EMS EMT Paramedic Prehospital Sepsis Source Type: news

Approaches in Prehospital Sepsis Screening
Discussion In the United States, sepsis is one of the leading causes of death, which requires timely identification and proper treatment (CDC, 2019; Guerra et al., 2020; Polito et al., 2015). Based upon a review of literature conducted from 2014 to 2018, the primary investigators could locate five prehospital EMS screening tools to assist EMS providers in identifying at-risk sepsis patients. The researchers explored how the modified SIRS and qSOFA scoring systems were used in hospital settings in addition to these five prehospital EMS screening tools. The Bas 90-30-90, Guerra, PRESEP, PRESS, and Robson tools have ove...
Source: JEMS Special Topics - January 5, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives Patient Care EMS EMT Paramedic Prehospital Sepsis Source Type: news

Approaches in Prehospital Sepsis Screening
Discussion In the United States, sepsis is one of the leading causes of death, which requires timely identification and proper treatment (CDC, 2019; Guerra et al., 2020; Polito et al., 2015). Based upon a review of literature conducted from 2014 to 2018, the primary investigators could locate five prehospital EMS screening tools to assist EMS providers in identifying at-risk sepsis patients. The researchers explored how the modified SIRS and qSOFA scoring systems were used in hospital settings in addition to these five prehospital EMS screening tools. The Bas 90-30-90, Guerra, PRESEP, PRESS, and Robson tools have ove...
Source: JEMS Operations - January 5, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives Patient Care EMS EMT Paramedic Prehospital Sepsis Source Type: news

Approaches in Prehospital Sepsis Screening
Discussion In the United States, sepsis is one of the leading causes of death, which requires timely identification and proper treatment (CDC, 2019; Guerra et al., 2020; Polito et al., 2015). Based upon a review of literature conducted from 2014 to 2018, the primary investigators could locate five prehospital EMS screening tools to assist EMS providers in identifying at-risk sepsis patients. The researchers explored how the modified SIRS and qSOFA scoring systems were used in hospital settings in addition to these five prehospital EMS screening tools. The Bas 90-30-90, Guerra, PRESEP, PRESS, and Robson tools have ove...
Source: JEMS Latest News - January 5, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives Patient Care EMS EMT Paramedic Prehospital Sepsis Source Type: news

Approaches in Prehospital Sepsis Screening
Discussion In the United States, sepsis is one of the leading causes of death, which requires timely identification and proper treatment (CDC, 2019; Guerra et al., 2020; Polito et al., 2015). Based upon a review of literature conducted from 2014 to 2018, the primary investigators could locate five prehospital EMS screening tools to assist EMS providers in identifying at-risk sepsis patients. The researchers explored how the modified SIRS and qSOFA scoring systems were used in hospital settings in addition to these five prehospital EMS screening tools. The Bas 90-30-90, Guerra, PRESEP, PRESS, and Robson tools have ove...
Source: JEMS Administration and Leadership - January 5, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives Patient Care EMS EMT Paramedic Prehospital Sepsis Source Type: news

Approaches in Prehospital Sepsis Screening
Discussion In the United States, sepsis is one of the leading causes of death, which requires timely identification and proper treatment (CDC, 2019; Guerra et al., 2020; Polito et al., 2015). Based upon a review of literature conducted from 2014 to 2018, the primary investigators could locate five prehospital EMS screening tools to assist EMS providers in identifying at-risk sepsis patients. The researchers explored how the modified SIRS and qSOFA scoring systems were used in hospital settings in addition to these five prehospital EMS screening tools. The Bas 90-30-90, Guerra, PRESEP, PRESS, and Robson tools have ove...
Source: JEMS Patient Care - January 5, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives Patient Care EMS EMT Paramedic Prehospital Sepsis Source Type: news

Soluble CD14 Subtype in Peripheral Blood is a Biomarker for Early Diagnosis of Sepsis
Objective To study the value of serum soluble CD14 subtype (sCD14-ST) in early diagnosis of sepsis. Methods Seventy-two patients were diagnosed with systemic inflammatory response syndrome, sepsis, or septic shock. Peripheral blood was collected at 0, 12, 24, and 48 hours after admission to the hospital. Levels of sCD14-ST, procalcitonin (PCT), hypersensitive C-reactive protein (CRP), and white blood cells (WBC) were determined. Results Levels of sCD14-ST in the patients with septic shock were higher than those in the other patients (P (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 10, 2020 Category: Consumer Health News Source Type: news

Pediatric Sepsis in the Time of Coronavirus Disease 2019
The volume of data and studies on coronavirus disease 2019 (COVID-19) disease caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has grown at a pace as unprecedented as the pandemic itself. Statistics and findings change weekly. Although pediatric cases have thankfully remained a small minority (1.7 –2%) of overall worldwide COVID-19 cases (2), the potential for severe illness in children remains and grows. Rapidly published pediatric case series have identified severe critical COVID-19–related illnesses associated with primary SARS-CoV-2 infection and findings consiste...
Source: Current Awareness Service for Health (CASH) - December 10, 2020 Category: Consumer Health News Source Type: news

" Perspective of the Surviving Sepsis Campaign on the Management of Pediatric Sepsis in the Era of Coronavirus Disease 2019. "
Severe acute respiratory syndrome coronavirus 2 is a novel cause of organ dysfunction in children, presenting as either coronavirus disease 2019 with sepsis and/or respiratory failure or a hyperinflammatory shock syndrome. Clinicians must now consider these diagnoses when evaluating children for septic shock and sepsis-associated organ dysfunction. The Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-associated Organ Dysfunction in Children provide an appropriate framework for the early recognition and initial resuscitation of children with sepsis or septic shock caused by al...
Source: Current Awareness Service for Health (CASH) - December 10, 2020 Category: Consumer Health News Source Type: news

Early, Deep, Durable Responses of Ciltacabtagene Autoleucel (cilta-cel) Observed in Phase 1b/2 CARTITUDE-1 Study Show Potential of BCMA CAR-T in Treatment of Heavily Pretreated Patients with Multiple Myeloma
December 5, 2020 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today longer-term results from the combined Phase 1b/2 CARTITUDE-1 study (NCT03548207) evaluating the efficacy and safety of ciltacabtagene autoleucel (cilta-cel), an investigational B cell maturation antigen (BCMA)-directed chimeric antigen receptor T cell (CAR-T) therapy, for the treatment of patients with relapsed and/or refractory multiple myeloma. These data, presented as an oral presentation at the American Society of Hematology (ASH) 2020 Annual Meeting (Abstract #177), continued to demonstrate a very hig...
Source: Johnson and Johnson - December 5, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival
Conclusion(s): Compared with younger patients, older sepsis survivors suffer both a higher persistent disability burden and 12-month mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 13, 2020 Category: Consumer Health News Source Type: news

Kambo frog poison as a cause of esophageal rupture - Robalino Gonzaga ES, Chamorro M, Ganti L, Schneider R.
The authors present a case of a patient  who used Kambo frog poison for body cleansing that induced severe vomiting and led to esophageal rupture followed by tension pneumothorax and septic shock. Kambo is the waxy substance secreted by the nocturnal gian... (Source: SafetyLit)
Source: SafetyLit - November 4, 2020 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news

Effect of IV Push Antibiotic Administration on Antibiotic Therapy Delays in Sepsis
Conclusion(s): Use of an IV push strategy may safely facilitate more rapid administration of beta-lactam antibiotics and may allow for better compliance with sepsis management guidelines. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Association of urinary albumin:Creatinine ratio with outcome of children with sepsis
Conclusion(s): Urinary ACR, a cost-effective tool, correlates with the severity of sepsis and associated morbidity and mortality in children. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Bundle adherence of intravenous antibiotic fluid resuscitation and vasopressor in children with severe sepsis or septic shock
Objective: The aim of this study was to measure the effects of a bundle of interventions in children admitted with severe sepsis or septic shock in the first hour after diagnosis on mortality. Material(s) and Method(s): A retrospective study was conducted at a pediatric intensive care unit (PICU) between January 2014 and January 2016. Three interventions (intravenous [IV] antibiotic, fluid boluses, and vasopressor administration) applied in the first hour of severe sepsis or septic shock diagnosis were analyzed according to their adherence rates. The main outcome was mortality. Odds ratios were calculated. Result(s): Of a ...
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

A single-center prospective cohort study on postsplenectomy sepsis and its prevention
This study evaluated the impact of a dedicated outpatient service on vaccination uptake after splenectomy and on the incidence of postsplenectomy sepsis. Methods. From 2009 to 2016 at the University Hospital Freiburg (Germany), asplenic patients were referred to a dedicated outpatient service, provided with comprehensive preventive care including vaccinations, and enrolled in a prospective cohort study. The impact of the service on vaccination uptake and the occurrence of severe sepsis/septic shock was compared between patients who had splenectomy (or were asplenic) within 3 months of study entry ( " early study entry...
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Hydrocortisone Early After Septic Shock Onset May Aid Outcomes
THURSDAY, Sept. 17, 2020 -- For patients with vasopressor-dependent septic shock, early hydrocortisone use is associated with improved outcomes, according to a study published online Sept. 2 in SHOCK. Gretchen L. Sacha, Pharm.D., from the Cleveland... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 17, 2020 Category: Pharmaceuticals Source Type: news

Long-term mortality and outcome in hospital survivors of septic shock, sepsis, and severe infections: The importance of aftercare
Patients with severe infections and especially sepsis have a high in-hospital mortality, but even hospital survivors face long-term sequelae, decreased health-related quality of life, and high risk of death, suggesting a great need for specialized aftercare. However, data regarding a potential benefit of post-discharge rehabilitation in these patients are scarce. In this retrospective matched cohort study the claim data of a large German statutory health care insurer was analyzed. 83,974 hospital survivors having suffered from septic shock, sepsis, and severe infections within the years 2009-2016 were identified using an I...
Source: Current Awareness Service for Health (CASH) - September 3, 2020 Category: Consumer Health News Source Type: news

An " in silico " Bench to Bedside Approach to Investigating Sepsis Biomarkers
Sepsis results in various patient complications and is due to a heightened inflammatory response against infection. This condition requires further exploration of biomarkers. We employed an " in silico " method comprised of text-mining and additionally clinical validation through the Medical Information Mart for Intensive Care. We highlight that Factor VIII shows potential as a pertinent septic shock biomarker. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 3, 2020 Category: Consumer Health News Source Type: news

Rates, predictors, and mortality of sepsis-associated acute kidney injury: A systematic review and meta-analysis
Conclusion(s): Risk factors of S-AKI arise from a wide range of sources, making it difficult to predict and prevent this condition. Comorbidities, and certain drugs, are the main risk factors for S-AKI. Our review can provide guidance on the application of interventions to reduce the risks associated with sepsis-associated acute kidney injury and can also be used to tailor patient-specific treatment plans and management strategies in clinical practice. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 3, 2020 Category: Consumer Health News Source Type: news

Epidemiology of sepsis and septic shock in intensive care units between sepsis-2 and sepsis-3 populations: sepsis prognostication in intensive care unit and emergency room (SPICE-ICU)
Conclusion(s): Most patients with infection admitted to ICU meet sepsis-2 and sepsis-3 criteria. However, in-hospital mortality did not occur if patients did not meet any criteria. Better criteria might be developed by better selection and combination of elements in both definitions. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 5, 2020 Category: Consumer Health News Source Type: news

What Are Some Pediatric Oncological Emergencies?
Discussion Pediatric cancers in the US number about 12,000 per year. After injury, it is the second leading cause of death in children and adolescents. Cancer presentations vary widely, but often begin with non-specific symptoms that continue or progress depending on the location and tumor type. Patients can present with oncological emergencies especially if there are mechanical obstruction such as superior vena cava syndrome or cerebral herniation. More commonly are infections due to immunosuppression. Cancer treatment also causes its own myriad of problems that clinicians need to be aware of to diagnosis and treat, but a...
Source: PediatricEducation.org - July 20, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

St18 is a negative regulator of VEGF
(National Institutes of Natural Sciences) A research team led by Kenta Maruyama M.D., Ph.D. from National Institute for Physiological Sciences explored the role of St18 in the regulation of VEGF expression. Mice lacking St18 in myeloid lineages are highly susceptible to septic shock. These mice also exhibit increased retinal vasculature with enhanced serum VEGF concentrations, and pharmacological inhibition of VEGF signaling rescues the high mortality rate of septic shock. These findings suggest that St18 is a negative regulator of VEGF. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 14, 2020 Category: International Medicine & Public Health Source Type: news

The therapeutic effect of high-volume hemofiltration on sepsis: A systematic review and meta-analysis
Conclusion(s): The meta-analysis results suggested that treatment programs contained HVHF did not change the outcomes of patients with sepsis. So far, related studies on the use of HVHF in critically ill patients with sepsis or septic shock is rare. Researchers should consider additional large multicenter randomized controlled trials. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 1, 2020 Category: Consumer Health News Source Type: news

Discontinuation of glycopeptides in patients with culture negative severe sepsis or septic shock: A propensity-matched retrospective cohort study
Implementation of antibiotic stewardship is difficult in patients with sepsis because of severity of disease. We evaluated the impact of glycopeptide discontinuation (GD) in patients with culture negative severe sepsis or septic shock who received glycopeptides as initial empiric antibiotic therapy at admission. We conducted a single center retrospective cohort study between January 2010 and March 2018. GD was defined as discontinuation of initial empiric glycopeptides on availability of culture results, revealing the absence of identified pathogens. In 92 included patients, the leading causes of sepsis were pneumonia (34....
Source: Current Awareness Service for Health (CASH) - July 1, 2020 Category: Consumer Health News Source Type: news

F-Actin is associated with a worsening qSOFA score and intensive care unit admission in emergency department patients at risk for sepsis
Conclusion(s): Increased levels of plasma F-actin measured in the ED were associated with incremental illness severity as measured by the qSOFA score and need for ICU admission. F-actin may have utility in risk stratification of undifferentiated patients in the ED presenting with signs and symptoms of sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 1, 2020 Category: Consumer Health News Source Type: news

Antihypotensive agent disrupts the immune system in sepsis
(Radboud University Medical Center) Patients who go into shock caused by sepsis (septic shock) are treated with the antihypotensive agent norepinephrine. Researchers from Radboud university medical center published results in today's American Journal of Respiratory and Critical Care Medicine revealing that its use is not without drawbacks: the drug disrupts the immune system and increases susceptibility to infections. This may have negative consequences for patients. Research into alternatives is therefore justified. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 11, 2020 Category: Infectious Diseases Source Type: news

Clinical outcomes of empirical high-dose meropenem in critically ill patients with sepsis and septic shock: A randomized controlled trial
Conclusion(s): Empirical therapy with the high-dose meropenem presented comparable clinical outcomes to the standard-dose meropenem in sepsis and septic shock patients. Besides, subgroup analysis manifested superior microbiological cure rate in sepsis or septic shock patients admitted from ED. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

The Role of Serum Procalcitonin in Predicting Bacterial Sepsis in Patients with Hypothyroidism
Conclusion(s): Despite the thyroidal origin of PCT, hypothyroidism did not affect the diagnostic performance of serum PCT levels in predicting bacterial sepsis or septic shock. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

New testing system predicts septic shock outcomes
(University of Chicago) PME professor Savas Tay and his collaborators have developed a new, extremely sensitive method that can quantify bacteria, an antibiotic resistant gene, and immune molecule levels within sepsis patients, far more rapidly than current protocols. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 26, 2020 Category: International Medicine & Public Health Source Type: news

Terlipressin for the Treatment of Septic Shock in Adults Terlipressin for the Treatment of Septic Shock in Adults
How does terlipressin, a synthetic vasopressin analogue, compare with catecholamine infusion in treating septic shock patients?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 11, 2020 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Presepsin values as markers of severity of sepsis
This study evaluated the diagnostic accuracy of presepsin, procalcitonin (PCT), and C-reactive protein (CRP) in differentiating sepsis severity as well as their association with Sepsis-related Organ Failure Assessment (SOFA) score. Method(s): One hundred septic patients from two university clinical centers were enrolled in the study during two time periods. New Sepsis-3 definitions were used for sepsis stratification. Biomarkers and SOFA score were evaluated four times during the illness. A sandwich ELISA kit was used for presepsin measurement. Generalized linear mixed effects model was used to test the changes in biomarke...
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news

Interleukin-31 interaction with inflammasome: A promising diagnostic and prognostic panel for early sepsis identification in critically ill patients
Purpose: This case-control study aimed to evaluate the ability to use a panel of IL-31, IL-1s and NLRP3 to differentiate sepsis from systemic inflammatory response syndrome (SIRS) and to predict septic shock. Method(s): Serum levels of IL-31, IL-1s and NLRP3 were measured by ELISA in 149 participants; 38 with sepsis, 51 with SIRS, 30 with septic shock and 30 healthy controls. Result(s): Lower levels of IL-31 were found in sepsis (10.21 +/- 4.34 pg/ml) compared to SIRS (16.74 +/- 3.18 pg/ml) and to controls with the lowest levels detected in septic shock (6.26 +/- 2.72 pg/ml). IL-1s and NLRP3 levels were higher in sepsis (5...
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news

Actor Nick Cordero's wife Amanda Kloots gives update on his long battle with coronavirus
Broadway actor Nick Cordero suffered a setback in his battle against the coronavirus when the 41-year-old Tony nominee went into septic shock after developing a lung infection. Cordero is in a medically induced coma and has been on a ventilator for a month. Gayle King speaks to his wife, fitness instructor Amanda Kloots, who says she is optimistic about his recovery. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - April 30, 2020 Category: Consumer Health News Source Type: news

Clinical Care for Severe Acute Respiratory Infection Toolkit: COVID-19 Adaptation
Source: World Health Organization (WHO). Published: 4/9/2020. This 196-page toolkit is intended for clinicians working in intensive care units in low- and middle-income countries, managing adult and pediatric patients with severe forms of acute respiratory infection, including severe pneumonia, acute respiratory distress syndrome, sepsis, and septic shock. It is a hands-on practical guide to be used by healthcare professionals involved in critical care management during the COVID-19 pandemic and outbreaks of influenza (seasonal or avian influenza), Middle East respiratory syndrome coronavirus (MERS-CoV), or other emerging...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - April 9, 2020 Category: International Medicine & Public Health Source Type: news

Myths in Emergency Medicine: Magic Bullets Rare in Medicine, Especially for Septic Shock
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - April 1, 2020 Category: Emergency Medicine Tags: Myths in Emergency Medicine Source Type: news

Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children
To develop evidence-based recommendations for clinicians caring for children (including infants, schoolaged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction. A large cohort of international experts was able to achieve consensus regarding many recommendations for the best care of children with sepsis, acknowledging that most aspects of care had relatively low quality of evidence resulting in the frequent issuance of weak recommendations. Despite this challenge, these recommendations regarding the management of children with septic shock and other sepsis-associated organ dysfunction ...
Source: Current Awareness Service for Health (CASH) - March 26, 2020 Category: Consumer Health News Source Type: news

Fluid resuscitation in sepsis: the great 30 mL per kg hoax.
Large volume fluid resuscitation is currently viewed as the cornerstone of the treatment of septic shock. The surviving sepsis campaign (SSC) guidelines provide a strong recommendation to rapidly administer a minimum of 30 mL/kg crystalloid solution intravenously in all patients with septic shock and those with elevated blood lactate levels. However, there is no credible evidence to support this recommendation. In fact, recent findings from experimental, observational and randomized clinical trials demonstrate improved outcomes with a more restrictive approach to fluid resuscitation. Accumulating evidence suggests that agg...
Source: Current Awareness Service for Health (CASH) - March 26, 2020 Category: Consumer Health News Source Type: news

Sepsis and septic shock: Guideline-based management
Sepsis is a life-threatening organ dysfunction that results from the body's response to infection. It requires prompt recognition, appropriate antibiotics, careful hemodynamic support, and control of the source of infection. With the trend in management moving away from protocolized care in favor of appropriate usual care, an understanding of sepsis physiology and best practice guidelines is critical. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 26, 2020 Category: Consumer Health News Source Type: news

Prognosis of beta-adrenergic blockade therapy on septic shock and sepsis: A systematic review and meta-analysis of randomized controlled studies
Purpose: beta-adrenoceptor antagonist (beta-blocker) may have potential in the treatment of septic shock and sepsis. However, the relevant research findings are still controversial. Method(s): We conducted a systematic review and meta-analysis to explore the efficacy of beta-blocker in patients with septic shock and sepsis. The primary sources of the reviewed studies through August 2018, with restriction on the language of English, were Pubmed and Embase. Randomized controlled trials (RCT) were included to evaluate the efficacy of beta-blocker in the treatment of septic shock and sepsis. Meta analysis was performed using a...
Source: Current Awareness Service for Health (CASH) - March 13, 2020 Category: Consumer Health News Source Type: news

A Multicenter Survey of House Staff Knowledge About Sepsis and the " Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock "
Background: We aimed to assess the knowledge, attitudes, and perceptions of resident physicians regarding sepsis in general and the Surviving Sepsis Campaign Guidelines in particular. Method(s): After institutional review board approval, we surveyed internal medicine (IM) and emergency medicine (EM) house staff from 3 separate institutions. House staff were notified of the survey via e-mail from their residency director or chief resident. The survey was Internet-based (using http://www.surveymonkey.com), voluntary, and anonymous. The Surviving Sepsis Campaign Guidelines were used to develop the survey. The survey was open ...
Source: Current Awareness Service for Health (CASH) - March 13, 2020 Category: Consumer Health News Source Type: news

Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis
Hypomagnesemia is a significant risk factor for critically ill patients to develop sepsis, a life-threatening disease with a mortality rate over 25%. Our clinic data analysis showed that hypomagnesemia is associated with a decreased monocyte count in septic patients. At the cellular level, we found that Mg2+ inhibits pyroptosis. Specifically, Mg2+ limits the oligomerization and membrane localization of gasdermin D N-terminal (GSDMD-NT) upon the activation of either the canonical or noncanonical pyroptotic pathway. Mechanistically, we demonstrated that Ca2+ influx is a prerequisite for the function of GSDMD-NT. Mg2+ blocks ...
Source: Current Awareness Service for Health (CASH) - March 13, 2020 Category: Consumer Health News Source Type: news

Associatio Between Volume of Fluid Resuscitation and Intubation in High-Risk Patients With Sepsis, Heart Failure, End-Stage Renal Disease, and Cirrhosis
This study was designed to assess the association between 30 mL/kg crystalloids and intubation in patients with sepsis or septic shock and heart failure, end-stage renal disease, or cirrhosis. Method(s): This propensity score-matched retrospective cohort study included patients with sepsis or septic shock admitted to a large medical ICU. Primary exposure was IV fluid volume in the first 6 h following sepsis diagnosis, divided into two cohorts:>= 30 mL/kg (standard group) and (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 13, 2020 Category: Consumer Health News Source Type: news

Current Controversies in Sepsis Management Current Controversies in Sepsis Management
This article explores topics of concern and discusses current management strategies.Seminars in Respiratory and Critical Care Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 3, 2020 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

Bioactive Adrenomedullin, measured with sphingotec's bio-ADM ® assay plays a key role in septic shock as top-line results of AdrenOSS-2 Phase II Study indicate
(sphingotec GmbH) AdrenOSS-2 Phase II trial shows that modulating the Adrenomedullin plasma level with the therapeutic antibody Adrecizumab demonstrates an improvement of survival in patients with septic shock. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 24, 2020 Category: International Medicine & Public Health Source Type: news

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial
RCT (n=216) found that treatment with intravenous vitamin C, hydrocortisone, and thiamine, compared with intravenous hydrocortisone alone, did not significantly improve the duration of time alive and free of vasopressor administration over 7 days. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 6, 2020 Category: Consumer Health News Source Type: news

WHO (World Health Organization) Critical Care Severe Acute Respiratory Infection Training
Source: World Health Organization (WHO). Published: 2/2020. This course, updated in February 2020, is intended for clinicians who are working in intensive care units in low- and middle-income countries, and managing adult and pediatric patients with severe forms of acute respiratory infection (SARI), including severe pneumonia, acute respiratory distress syndrome, sepsis, and septic shock. It is a hands-on practical guide to be used by health care professionals involved in critical care management during outbreaks of influenza virus (seasonal), human infection due to avian influenza virus (H5N1, H7N9), MERS-CoV, nCoV or o...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - February 1, 2020 Category: International Medicine & Public Health Source Type: news

High-Dose IV Vitamin C Does Not Speed Resolution of Septic Shock
FRIDAY, Jan. 24, 2020 -- Treatment with intravenous vitamin C, hydrocortisone, and thiamine does not improve the duration of time alive and vasopressor administration-free compared with intravenous hydrocortisone alone among patients with septic... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 24, 2020 Category: Pharmaceuticals Source Type: news