Effect of Ultrashort-Acting β-Blockers on Mortality in Patients With Sepsis With Persistent Tachycardia Despite Initial Resuscitation: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Review of 7 RCTs (n=613) reported significantly lower 28-day mortality with ultra-short acting β-blockers esmolol and landiolol vs placebo/no-intervention in patients with sepsis& septic shock (RR 0.68, 95% CI 0.54-0.85). Absolute risk reduction was 18.2% and NNT was 5.5. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 16, 2021 Category: Consumer Health News Source Type: news

Quantitative and Qualitative Assessments of Cholesterol Association With Bacterial Infection Type in Sepsis and Septic Shock
Background: Reduced cholesterol levels are associated with increased organ failure and mortality in sepsis. Cholesterol levels may vary by infection type (gram negative vs positive), possibly reflecting differences in cholesterol-mediated bacterial clearance. Methods: This was a secondary analysis of a combined data set of 2 prospective cohort studies of adult patients meeting Sepsis-3 criteria. Infection types were classified as gram negative, gram positive, or culture negative. We investigated quantitative (levels) and qualitative (dysfunctional high-density lipoprotein [HDL]) cholesterol differences. We used multivariab...
Source: Current Awareness Service for Health (CASH) - June 9, 2021 Category: Consumer Health News Source Type: news

Impact of the timeliness of antibiotic therapy on the outcome of patients with sepsis and septic shock
Conclusions: While two-thirds of sepsis studies reported an association between early administration of antibiotic therapy and patient outcome, the time-to-antibitiocs metrics varied significantly across studies and no robust time thresholds emerged. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 9, 2021 Category: Consumer Health News Source Type: news

Maternal Sepsis: presentation, course, treatment and outcomes
The current adult definition of sepsis and septic shock, as developed in 1992, does not adequately define sepsis in the pregnant and peripartum women due to the alteration of sepsis presentation in the maternal population. The purpose of this study was to determine potential causative factors for sepsis with the aim of prevention and reducing morbidity and mortality. Study Design and Methods: A descriptive observational design via a retrospective medical record review was used with a convenience sample of 22 women who were identified after admission as having sepsis. The setting was the labor and delivery unit of a large u...
Source: Current Awareness Service for Health (CASH) - June 9, 2021 Category: Consumer Health News Source Type: news

The role of eosinophils in sepsis and acute respiratory distress syndrome: a scoping review, Canadian journal of anaesthesia
Conclusion: Persistent peripheral eosinopenia is a marker of bacterial sepsis and is independently associated with poor outcomes. Bronchoalveolar lavage eosinophil counts are low in early-phase ARDS, but increase in late-phase ARDS, while elevated markers of eosinophil activity correlate with ARDS severity. Further studies understanding the mechanisms leading to eosinopenia in sepsis and increased eosinophil activity in ARDS are needed. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2021 Category: Consumer Health News Source Type: news

Machine learning methods to improve bedside fluid responsiveness prediction in severe sepsis or septic shock: an observational study, British journal of anaesthesia
Conclusions: Machine learning generated several models for predicting fluid responsiveness that were comparable with the haemodynamic response to PLR. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2021 Category: Consumer Health News Source Type: news

Predictive value of geriatric-quickSOFA in hospitalized older people with sepsis, BMC geriatrics
Background: QuickSOFA, a prognostic score proposed for patients with infection, has shown a poor predictive value in the geriatric population, probably because of the inappropriateness of the Glasgow Coma Scale (GCS) in assessing acute alteration of mental status in older patients. Indeed, the GCS might result chronically low in older patient with pre-existing cognitive disorders. The aim of this study was to develop an alternative quickSOFA (geriatric-quickSOFA), using the presence of delirium, assessed according to DSM-5 criteria, instead of GCS assessment, to predict mortality in hospitalized older patients with sepsis....
Source: Current Awareness Service for Health (CASH) - May 6, 2021 Category: Consumer Health News Source Type: news

Adherence to CMS SEP-1 measures found to have variable effects on patient outcomes
(American College of Physicians) A longitudinal study found that adherence to the Medicare Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) had variable effects on sepsis treatment and patient outcomes in its current iteration, which requires that a patient receive all measure components for their treatment to be considered compliant. The findings are published in Annals of Internal Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 19, 2021 Category: Infectious Diseases Source Type: news

Federal policy to reduce deaths from sepsis was mostly ineffective
(University of Pittsburgh) The first large-scale, multi-hospital evaluation of an " all or none " federal policy intended to improve results in sepsis patients finds that the guidelines are a wash - on average they neither helped nor hurt outcomes despite significant investments in their implementation. The findings indicate ways the Severe Sepsis and Septic Shock: Management Bundle, known as " SEP-1, " could be built upon and changed to potentially result in future improvements. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 19, 2021 Category: Infectious Diseases Source Type: news

Prognostic value of lactate levels and lactate clearance in sepsis and septic shock with initial hyperlactatemia: A retrospective cohort study according to the Sepsis-3 definitions, Medicine
This study evaluated the prognostic value of lactate levels and lactate clearance for 30-day mortality in patients with sepsis and septic shock diagnosed in the emergency department.We performed a retrospective cohort study of sepsis patients with initial lactate levels of ≥2 mmol/L. All patients met the Sepsis-3 definitions. The prognostic value of 6-hour lactate levels, 6-hour lactate clearance, 6-hour lactate metrics (≥2 mmol/L), and lactate clearance metrics ( (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news

Comparing mortality between positive and negative blood culture results: an inverse probability of treatment weighting analysis of a multicenter cohort, BMC Infectious Diseases
Conclusions: Culture-positive sepsis patients had comparable early mortality but worse late mortality than culture-negative sepsis patients in this cohort. Persistent Staphylococcal bacteremia may have contributed to the increased late mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news

Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19, Frontiers in immunology
Sepsis is a life-threatening systemic illness attributed to a dysregulated host response to infection. Sepsis is a global burden killing ~11 million persons annually. In December 2019, a novel pneumonia condition termed coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged and has resulted in more than 1,535,982 deaths globally as of 8 th December 2020. These two conditions share many pathophysiological and clinical features. Notably, both sepsis and COVID-19 patients experience consumptive thrombocytopenia, haemolytic anaemia, vascular microthrombosis, multi-o...
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news

Early Recognition and Management of Sepsis in the Elderly: A Case Study, Critical Care Nursing Quarterly
This article aims to inform clinicians and nurses of the importance of early recognition of subtle signs and symptoms and the management of sepsis in the elderly. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news

The pandemic has given me extra time with my teenage sons
It ’s been a tough time to be 17 or 18, but there have been some upsides, tooMy sons are 18 and 17. It was the younger ’s birthday this week and I made an awful cake that definitely breached myminimum cake standards (I hesitate to criticise Nigella, but there is such a thing as too much peanut butter). He looked a bit overwhelmed when we sang happy birthday, and I worried all day about him and his 17-year-old pandemic life, without access to the places and people that help being 17 make sense. There is nothing I can do about that, so I am fixating on the cake, sitting here wondering if I have time to make a rep...
Source: Guardian Unlimited Science - March 13, 2021 Category: Science Authors: Emma Beddington Tags: Life and style Family Children Parents and parenting Psychology Science Health & wellbeing Source Type: news

Adrecizumab: an investigational agent for the biomarker-guided treatment of sepsis, Expert opinion on investigational drugs 30(2): 95-102
Sepsis is a major health problem with a high incidence and mortality. ADM, a free-circulating peptide mainly expressed and secreted by vascular endothelial cells, shows vasodilatory properties and causes hypotension when present in higher concentrations during sepsis. Areas covered : Adrecizumab (ADZ) (HAM 8101) is a humanized targeted therapy directed against the N-terminus of adrenomedullin (ADM). ADZ inhibits excessive circulating sepsis-induced ADM and stimulates protective effects on the endothelial barrier, and decreases interstitial vasodilatory effects. ADZ demonstrated a promising safety profile in healthy subject...
Source: Current Awareness Service for Health (CASH) - March 4, 2021 Category: Consumer Health News Source Type: news

Pediatric infection and sepsis in five age subgroups: single-center registry, Wiener medizinische Wochenschrift,171(1-2): 29-35
Conclusion: With this registry, children divided into five age subgroups with infection or sepsis were evaluated and treatment strategies were examined. We have shown that our findings on children treated in our pediatric intensive care unit conform with current literature about pediatric sepsis. In addition to maintaining strict hygiene standards, optimal aspects of sepsis care should be stringently observed, such as the quick administration of empirical broad-spectrum antibiotics, initial adequate fluid resuscitation, and a reliable and frequent routine of source control. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 4, 2021 Category: Consumer Health News Source Type: news

Sepsis and Septic Shock Definitions in Patients With Cancer Admitted in ICU, Journal of Intensive Care Medicine 36(34): 255-261
Conclusion: The new definition of sepsis and septic shock is applicable in an ICU oncological population with the same reliability as in the general population. The SOFA score is more accurate than qSOFA and SIRS criteria to predict hospital mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 3, 2021 Category: Consumer Health News Source Type: news

Is lactate lower in septic patients who are prescribed beta blockers? Retrospective cohort study of an intensive care population, Emergency Medicine Australasia 33(1): 82-87
Conclusions: In our cohort pre‐existing beta blocker treatment was associated with lower serum lactate measurements in patients presenting with sepsis. Pre‐existing beta blocker treatment may reduce serum lactate at presentatio n in patients with sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 3, 2021 Category: Consumer Health News Source Type: news

Sepsis in patients with haematological versus solid cancer: a retrospective cohort study
Study (n=442) found solid tumour patients with sepsis or septic shock are at the same risk of mortality as patients with haematological tumours. However, haematological malignancy patients admitted with sepsis or septic shock had higher rates of bacteraemia. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 18, 2021 Category: Consumer Health News Source Type: news

Two distinct pathways leading to the development of septic shock pave the way for personalized medicine in sepsis
(sphingotec GmbH) Diagnostics company SphingoTec GmbH announced today that two distinct processes are involved in the development of septic shock and that SphingoTec's biomarkers for endothelial function (vascular integrity) and cardiovascular depression allow early identification of these underlying mechanisms requiring different interventions. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 18, 2021 Category: International Medicine & Public Health Source Type: news

Incidence of Multidrug Resistant Infections in Emergency Department Patients with Suspected Sepsis, The American journal of the medical sciences 360(6): 650-655
Background: Inappropriate antibiotic therapy in sepsis is associated with poor outcomes, clinicians often provide routine coverage for multidrug resistant (MDR) bacteria. However, these regimens may contribute to problems related to antibiotic overuse. To understand the incidence and related factors of multidrug resistant bacterial infections in ED patients with sepsis, we examined how often patients with sepsis in our emergency department had MDR infections. We also explored risk factors for, and outcomes from, MDR bacterial infections.; Methods: We reviewed records of patients presenting to our emergency department (ED) ...
Source: Current Awareness Service for Health (CASH) - February 11, 2021 Category: Consumer Health News Source Type: news

Effectiveness of corticosteroids in patients with sepsis or septic shock using the new third international consensus definitions (Sepsis-3): A retrospective observational study, PLoS One 15(12): e0243149
Conclusions: In patients with sepsis or septic shock, intravenous corticosteroids were not associated with a higher in-hospital survival up to 50 days regardless of the sepsis definitions. Further research may be necessary to definitively confirm effectiveness in real-world practice. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 11, 2021 Category: Consumer Health News Source Type: news

New tests promise to improve sepsis diagnosis and treatment, MLO: Medical Laboratory Observer 53(2): 22-23
Sepsis represents the ultimate clinical ticking clock - given that patient mortality rates increase nearly 8 percent for each hour that appropriate treatment is delayed.1 Years ago, testing options for patients suspected of having bloodstream infections were limited to culture-based workflows, which take several days to deliver final results. Because these symptoms overlap with so many other health conditions, it is impossible to confirm a suspected diagnosis of sepsis without a lab test. In this stage, mortality rates climb to 40 percent, and patients who survive septic shock may develop lifelong complications from blood ...
Source: Current Awareness Service for Health (CASH) - February 11, 2021 Category: Consumer Health News Source Type: news

Comparison of Manual and Automated Sepsis Screening Tools in a Pediatric Emergency Department, Pediatrics 147(2): 1-9
CONCLUSIONS: An automated sepsis screening algorithm had higher sensitivity and specificity than a widely used manual sepsis screen and was performed on 100% of patients in the ED, ensuring continuous sepsis surveillance throughout the ED stay. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 11, 2021 Category: Consumer Health News Source Type: news

Study identifies noncoding RNA involved in immune response and sepsis
(University of California - Santa Cruz) When the body's immune response to an infection gets out of control, the result can be sepsis, a life-threatening condition in which an overwhelming inflammatory response can lead rapidly to failure of multiple organs and death. In a new study, researchers at UC Santa Cruz have identified a long noncoding RNA (lncRNA) molecule that regulates the expression of pro-inflammatory genes in immune system cells called macrophages and affects the susceptibility of mice to septic shock. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 1, 2021 Category: Infectious Diseases Source Type: news

Mesenchymal stromal cells for sepsis and septic shock: Lessons for treatment of COVID-19. Stem cells translational medicine 9(12): 1488-1494.
Sepsis is defined as life-threatening organ dysfunction caused by a deregulated immune host response to infection. The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted this multifactorial and complex syndrome. The absence of specific treatment neither against SARS-CoV-2 nor against acute respiratory distress syndrome (ARDS), the most serious stage of this infection, has emphasized the need to find alternative treatments. Several therapeutics are currently being tested, including mesenchymal stromal cells. These cells, already used in preclinical models of ARDS, sepsis, and septi...
Source: Current Awareness Service for Health (CASH) - January 8, 2021 Category: Consumer Health News Source Type: news

Resistant Infections in Emergency Department Patients with Suspected Sepsis. The American journal of the medical sciences 360(6): 650-655.
Background: Inappropriate antibiotic therapy in sepsis is associated with poor outcomes, clinicians often provide routine coverage for multidrug resistant (MDR) bacteria. However, these regimens may contribute to problems related to antibiotic overuse. To understand the incidence and related factors of multidrug resistant bacterial infections in ED patients with sepsis, we examined how often patients with sepsis in our emergency department had MDR infections. We also explored risk factors for, and outcomes from, MDR bacterial infections.; Methods: We reviewed records of patients presenting to our emergency department (ED) ...
Source: Current Awareness Service for Health (CASH) - January 8, 2021 Category: Consumer Health News Source Type: news

Approaches in Prehospital Sepsis Screening
Discussion In the United States, sepsis is one of the leading causes of death, which requires timely identification and proper treatment (CDC, 2019; Guerra et al., 2020; Polito et al., 2015). Based upon a review of literature conducted from 2014 to 2018, the primary investigators could locate five prehospital EMS screening tools to assist EMS providers in identifying at-risk sepsis patients. The researchers explored how the modified SIRS and qSOFA scoring systems were used in hospital settings in addition to these five prehospital EMS screening tools. The Bas 90-30-90, Guerra, PRESEP, PRESS, and Robson tools have ove...
Source: JEMS Patient Care - January 5, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives Patient Care EMS EMT Paramedic Prehospital Sepsis Source Type: news

Approaches in Prehospital Sepsis Screening
Discussion In the United States, sepsis is one of the leading causes of death, which requires timely identification and proper treatment (CDC, 2019; Guerra et al., 2020; Polito et al., 2015). Based upon a review of literature conducted from 2014 to 2018, the primary investigators could locate five prehospital EMS screening tools to assist EMS providers in identifying at-risk sepsis patients. The researchers explored how the modified SIRS and qSOFA scoring systems were used in hospital settings in addition to these five prehospital EMS screening tools. The Bas 90-30-90, Guerra, PRESEP, PRESS, and Robson tools have ove...
Source: JEMS Administration and Leadership - January 5, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives Patient Care EMS EMT Paramedic Prehospital Sepsis Source Type: news

Approaches in Prehospital Sepsis Screening
Discussion In the United States, sepsis is one of the leading causes of death, which requires timely identification and proper treatment (CDC, 2019; Guerra et al., 2020; Polito et al., 2015). Based upon a review of literature conducted from 2014 to 2018, the primary investigators could locate five prehospital EMS screening tools to assist EMS providers in identifying at-risk sepsis patients. The researchers explored how the modified SIRS and qSOFA scoring systems were used in hospital settings in addition to these five prehospital EMS screening tools. The Bas 90-30-90, Guerra, PRESEP, PRESS, and Robson tools have ove...
Source: JEMS Latest News - January 5, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives Patient Care EMS EMT Paramedic Prehospital Sepsis Source Type: news

Approaches in Prehospital Sepsis Screening
Discussion In the United States, sepsis is one of the leading causes of death, which requires timely identification and proper treatment (CDC, 2019; Guerra et al., 2020; Polito et al., 2015). Based upon a review of literature conducted from 2014 to 2018, the primary investigators could locate five prehospital EMS screening tools to assist EMS providers in identifying at-risk sepsis patients. The researchers explored how the modified SIRS and qSOFA scoring systems were used in hospital settings in addition to these five prehospital EMS screening tools. The Bas 90-30-90, Guerra, PRESEP, PRESS, and Robson tools have ove...
Source: JEMS: Journal of Emergency Medical Services News - January 5, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives Patient Care EMS EMT Paramedic Prehospital Sepsis Source Type: news

Approaches in Prehospital Sepsis Screening
Discussion In the United States, sepsis is one of the leading causes of death, which requires timely identification and proper treatment (CDC, 2019; Guerra et al., 2020; Polito et al., 2015). Based upon a review of literature conducted from 2014 to 2018, the primary investigators could locate five prehospital EMS screening tools to assist EMS providers in identifying at-risk sepsis patients. The researchers explored how the modified SIRS and qSOFA scoring systems were used in hospital settings in addition to these five prehospital EMS screening tools. The Bas 90-30-90, Guerra, PRESEP, PRESS, and Robson tools have ove...
Source: JEMS Operations - January 5, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives Patient Care EMS EMT Paramedic Prehospital Sepsis Source Type: news

Approaches in Prehospital Sepsis Screening
Discussion In the United States, sepsis is one of the leading causes of death, which requires timely identification and proper treatment (CDC, 2019; Guerra et al., 2020; Polito et al., 2015). Based upon a review of literature conducted from 2014 to 2018, the primary investigators could locate five prehospital EMS screening tools to assist EMS providers in identifying at-risk sepsis patients. The researchers explored how the modified SIRS and qSOFA scoring systems were used in hospital settings in addition to these five prehospital EMS screening tools. The Bas 90-30-90, Guerra, PRESEP, PRESS, and Robson tools have ove...
Source: JEMS Special Topics - January 5, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives Patient Care EMS EMT Paramedic Prehospital Sepsis Source Type: news

Soluble CD14 Subtype in Peripheral Blood is a Biomarker for Early Diagnosis of Sepsis
Objective To study the value of serum soluble CD14 subtype (sCD14-ST) in early diagnosis of sepsis. Methods Seventy-two patients were diagnosed with systemic inflammatory response syndrome, sepsis, or septic shock. Peripheral blood was collected at 0, 12, 24, and 48 hours after admission to the hospital. Levels of sCD14-ST, procalcitonin (PCT), hypersensitive C-reactive protein (CRP), and white blood cells (WBC) were determined. Results Levels of sCD14-ST in the patients with septic shock were higher than those in the other patients (P (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 10, 2020 Category: Consumer Health News Source Type: news

Pediatric Sepsis in the Time of Coronavirus Disease 2019
The volume of data and studies on coronavirus disease 2019 (COVID-19) disease caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has grown at a pace as unprecedented as the pandemic itself. Statistics and findings change weekly. Although pediatric cases have thankfully remained a small minority (1.7 –2%) of overall worldwide COVID-19 cases (2), the potential for severe illness in children remains and grows. Rapidly published pediatric case series have identified severe critical COVID-19–related illnesses associated with primary SARS-CoV-2 infection and findings consiste...
Source: Current Awareness Service for Health (CASH) - December 10, 2020 Category: Consumer Health News Source Type: news

" Perspective of the Surviving Sepsis Campaign on the Management of Pediatric Sepsis in the Era of Coronavirus Disease 2019. "
Severe acute respiratory syndrome coronavirus 2 is a novel cause of organ dysfunction in children, presenting as either coronavirus disease 2019 with sepsis and/or respiratory failure or a hyperinflammatory shock syndrome. Clinicians must now consider these diagnoses when evaluating children for septic shock and sepsis-associated organ dysfunction. The Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-associated Organ Dysfunction in Children provide an appropriate framework for the early recognition and initial resuscitation of children with sepsis or septic shock caused by al...
Source: Current Awareness Service for Health (CASH) - December 10, 2020 Category: Consumer Health News Source Type: news

Early, Deep, Durable Responses of Ciltacabtagene Autoleucel (cilta-cel) Observed in Phase 1b/2 CARTITUDE-1 Study Show Potential of BCMA CAR-T in Treatment of Heavily Pretreated Patients with Multiple Myeloma
December 5, 2020 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today longer-term results from the combined Phase 1b/2 CARTITUDE-1 study (NCT03548207) evaluating the efficacy and safety of ciltacabtagene autoleucel (cilta-cel), an investigational B cell maturation antigen (BCMA)-directed chimeric antigen receptor T cell (CAR-T) therapy, for the treatment of patients with relapsed and/or refractory multiple myeloma. These data, presented as an oral presentation at the American Society of Hematology (ASH) 2020 Annual Meeting (Abstract #177), continued to demonstrate a very hig...
Source: Johnson and Johnson - December 5, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival
Conclusion(s): Compared with younger patients, older sepsis survivors suffer both a higher persistent disability burden and 12-month mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 13, 2020 Category: Consumer Health News Source Type: news

Kambo frog poison as a cause of esophageal rupture - Robalino Gonzaga ES, Chamorro M, Ganti L, Schneider R.
The authors present a case of a patient  who used Kambo frog poison for body cleansing that induced severe vomiting and led to esophageal rupture followed by tension pneumothorax and septic shock. Kambo is the waxy substance secreted by the nocturnal gian... (Source: SafetyLit)
Source: SafetyLit - November 4, 2020 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news

Effect of IV Push Antibiotic Administration on Antibiotic Therapy Delays in Sepsis
Conclusion(s): Use of an IV push strategy may safely facilitate more rapid administration of beta-lactam antibiotics and may allow for better compliance with sepsis management guidelines. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Association of urinary albumin:Creatinine ratio with outcome of children with sepsis
Conclusion(s): Urinary ACR, a cost-effective tool, correlates with the severity of sepsis and associated morbidity and mortality in children. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Bundle adherence of intravenous antibiotic fluid resuscitation and vasopressor in children with severe sepsis or septic shock
Objective: The aim of this study was to measure the effects of a bundle of interventions in children admitted with severe sepsis or septic shock in the first hour after diagnosis on mortality. Material(s) and Method(s): A retrospective study was conducted at a pediatric intensive care unit (PICU) between January 2014 and January 2016. Three interventions (intravenous [IV] antibiotic, fluid boluses, and vasopressor administration) applied in the first hour of severe sepsis or septic shock diagnosis were analyzed according to their adherence rates. The main outcome was mortality. Odds ratios were calculated. Result(s): Of a ...
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

A single-center prospective cohort study on postsplenectomy sepsis and its prevention
This study evaluated the impact of a dedicated outpatient service on vaccination uptake after splenectomy and on the incidence of postsplenectomy sepsis. Methods. From 2009 to 2016 at the University Hospital Freiburg (Germany), asplenic patients were referred to a dedicated outpatient service, provided with comprehensive preventive care including vaccinations, and enrolled in a prospective cohort study. The impact of the service on vaccination uptake and the occurrence of severe sepsis/septic shock was compared between patients who had splenectomy (or were asplenic) within 3 months of study entry ( " early study entry...
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Hydrocortisone Early After Septic Shock Onset May Aid Outcomes
THURSDAY, Sept. 17, 2020 -- For patients with vasopressor-dependent septic shock, early hydrocortisone use is associated with improved outcomes, according to a study published online Sept. 2 in SHOCK. Gretchen L. Sacha, Pharm.D., from the Cleveland... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 17, 2020 Category: Pharmaceuticals Source Type: news

Long-term mortality and outcome in hospital survivors of septic shock, sepsis, and severe infections: The importance of aftercare
Patients with severe infections and especially sepsis have a high in-hospital mortality, but even hospital survivors face long-term sequelae, decreased health-related quality of life, and high risk of death, suggesting a great need for specialized aftercare. However, data regarding a potential benefit of post-discharge rehabilitation in these patients are scarce. In this retrospective matched cohort study the claim data of a large German statutory health care insurer was analyzed. 83,974 hospital survivors having suffered from septic shock, sepsis, and severe infections within the years 2009-2016 were identified using an I...
Source: Current Awareness Service for Health (CASH) - September 3, 2020 Category: Consumer Health News Source Type: news

An " in silico " Bench to Bedside Approach to Investigating Sepsis Biomarkers
Sepsis results in various patient complications and is due to a heightened inflammatory response against infection. This condition requires further exploration of biomarkers. We employed an " in silico " method comprised of text-mining and additionally clinical validation through the Medical Information Mart for Intensive Care. We highlight that Factor VIII shows potential as a pertinent septic shock biomarker. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 3, 2020 Category: Consumer Health News Source Type: news

Rates, predictors, and mortality of sepsis-associated acute kidney injury: A systematic review and meta-analysis
Conclusion(s): Risk factors of S-AKI arise from a wide range of sources, making it difficult to predict and prevent this condition. Comorbidities, and certain drugs, are the main risk factors for S-AKI. Our review can provide guidance on the application of interventions to reduce the risks associated with sepsis-associated acute kidney injury and can also be used to tailor patient-specific treatment plans and management strategies in clinical practice. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 3, 2020 Category: Consumer Health News Source Type: news

Epidemiology of sepsis and septic shock in intensive care units between sepsis-2 and sepsis-3 populations: sepsis prognostication in intensive care unit and emergency room (SPICE-ICU)
Conclusion(s): Most patients with infection admitted to ICU meet sepsis-2 and sepsis-3 criteria. However, in-hospital mortality did not occur if patients did not meet any criteria. Better criteria might be developed by better selection and combination of elements in both definitions. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 5, 2020 Category: Consumer Health News Source Type: news

What Are Some Pediatric Oncological Emergencies?
Discussion Pediatric cancers in the US number about 12,000 per year. After injury, it is the second leading cause of death in children and adolescents. Cancer presentations vary widely, but often begin with non-specific symptoms that continue or progress depending on the location and tumor type. Patients can present with oncological emergencies especially if there are mechanical obstruction such as superior vena cava syndrome or cerebral herniation. More commonly are infections due to immunosuppression. Cancer treatment also causes its own myriad of problems that clinicians need to be aware of to diagnosis and treat, but a...
Source: PediatricEducation.org - July 20, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

St18 is a negative regulator of VEGF
(National Institutes of Natural Sciences) A research team led by Kenta Maruyama M.D., Ph.D. from National Institute for Physiological Sciences explored the role of St18 in the regulation of VEGF expression. Mice lacking St18 in myeloid lineages are highly susceptible to septic shock. These mice also exhibit increased retinal vasculature with enhanced serum VEGF concentrations, and pharmacological inhibition of VEGF signaling rescues the high mortality rate of septic shock. These findings suggest that St18 is a negative regulator of VEGF. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 14, 2020 Category: International Medicine & Public Health Source Type: news