Evaluating Vitamin C in Septic Shock
RCT (n=124) found vitamin C monotherapy (1000mg bolus followed by continuous infusion 250 mg/hr for 96 hours) failed to significantly reduce mortality (all-cause 28-day mortality: 26.7% vitamin C vs. 40.6% placebo; p=0.10), not supporting routine clinical use for this purpose. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 14, 2022 Category: Consumer Health News Source Type: news

Beyond the bundle: Clinical controversies in the management of sepsis in emergency medicine patients
Sepsis is a condition characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection. The emergency department (ED) serves as a crucial entry point for patients presenting with sepsis. Given the heterogeneous presentation and high mortality rate associated with sepsis and septic shock, several clinical controversies have emerged in the management of sepsis. These include the use of novel therapeutic agents like angiotensin II, hydrocortisone, ascorbic acid, thiamine ( " HAT " ) therapy, and levosimendan, Additionally, controversies with current treatments in vasopressor do...
Source: Current Awareness Service for Health (CASH) - January 11, 2022 Category: Consumer Health News Source Type: news

Blood purification in sepsis and systemic inflammation
Purpose of Review: Sepsis and septic shock are life-threatening diseases with high mortality. Although efforts have made to improve the survivals, the outcomes are still frustrating. Blood purification was thought to be a promising adjunctive therapy to regulate the excessive cytokine storm or to reduce the endotoxin activity caused by sepsis. Critically ill COVID-19 characterized with the similar disease to sepsis may also benefit from blood purification. Recent Findings: The recent studies mainly focused on hemadsorption materials. The results of the clinical trials showed a tendency in decrease of cytokine levels and e...
Source: Current Awareness Service for Health (CASH) - January 11, 2022 Category: Consumer Health News Source Type: news

The Effect of Body Mass Index and Weight-Adjusted Fluid Dosing on Mortality in Sepsis.
Conclusions: An exponential, dose-effect increase in mortality w as observed for underweight patients not receiving 30by3. Therefore, the mortality impact of under-dosing may be amplified using ABW for underweight patients. Fluid dosing did not impact mortality for obese patients, but we caution against deviation from guidelines without further studies. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 11, 2022 Category: Consumer Health News Source Type: news

Sepsis Definitions: I Know It When I See It*
Over the past 3 –4 decades, efforts have been made to define sepsis, severe sepsis, and septic shock more objectively. For purposes of this editorial, “sepsis” will include the full spectrum of sepsis, severe sepsis, and septic shock. Why is sepsis so difficult to define? There are many signs, symptoms, and l aboratory abnormalities that commonly occur in patients with sepsis, but there is not a single “gold standard” definition or criterion that clinicians can all agree on and that facilitates the prompt recognition of the syndrome. The manifestations of sepsis are highly variable, and an inf...
Source: Current Awareness Service for Health (CASH) - January 11, 2022 Category: Consumer Health News Source Type: news

Blood purification in sepsis and systemic inflammation
Purpose of Review: Sepsis and septic shock are life-threatening diseases with high mortality. Although efforts have made to improve the survivals, the outcomes are still frustrating. Blood purification was thought to be a promising adjunctive therapy to regulate the excessive cytokine storm or to reduce the endotoxin activity caused by sepsis. Critically ill COVID-19 characterized with the similar disease to sepsis may also benefit from blood purification. Recent Findings: The recent studies mainly focused on hemadsorption materials. The results of the clinical trials showed a tendency in decrease of cytokine levels and e...
Source: Current Awareness Service for Health (CASH) - December 8, 2021 Category: Consumer Health News Source Type: news

Effect of Undertriage on the Outcomes of Cancer Patients with Febrile Neutropenia, Sepsis, and Septic Shock
The objective was to study whether patients with neutropenia, sepsis, and septic shock were identified appropriately at triage and receive timely treatment within the emergency setting. Also, we investigated the effect of undertriage on key treatment outcomes. We conducted a retrospective analysis of all accessible records of admitted adult cancer patients with febrile neutropenia, sepsis, and septic shock. Our results identified that the majority of patients were inappropriately triaged to less urgent triage categories. Patients'undertriage significantly prolonged multiple emergency timeliness indicators and extended leng...
Source: Current Awareness Service for Health (CASH) - December 8, 2021 Category: Consumer Health News Source Type: news

Macrocirculatory and Microcirculatory Endpoints in Sepsis Resuscitation
Sepsis is a common disease process encountered by physicians. Sepsis can lead to septic shock, which carries a hospital mortality rate in excess of 40%. Although the Surviving Sepsis Guidelines recommend targeting a mean arterial pressure (MAP) of 65 mmHg and normalization of lactate, these endpoints do not necessarily result in tissue perfusion in states of shock. While MAP and lactate are commonly used markers in resuscitation, clinicians may be able to improve their resuscitation by broadening their assessment of the microcirculation, which more adequately reflects tissue perfusion. As such, in order to achieve a succes...
Source: Current Awareness Service for Health (CASH) - December 8, 2021 Category: Consumer Health News Source Type: news

Greater Compliance With Early Sepsis Management is Associated With Safer Care and Shorter Hospital Stay
This retrospective, cross-sectional study of U.S. hospitals in Medicare's Inpatient Quality Reporting Program aimed to determine whether variation in Sepsis/Septic Shock (Bundle SEP-1) compliance is linked to hospital size and measures of safety and operational efficiency. Two thousand six hundred and fifty-three acute care hospitals in Medicare's Hospital Compare online database were included in the study. Relationships between SEP-1 bundle compliance, hospital size, and indices of operational excellence (including Patient Safety Index [PSI-90], average length of stay [ALOS] and readmission rate) were analyzed. SEP-1 comp...
Source: Current Awareness Service for Health (CASH) - December 8, 2021 Category: Consumer Health News Source Type: news

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021
The recommendations in this document are intended to provide guidance for the clinician caring for adult patients with sepsis or septic shock in the hospital setting. These guidelines are intended to reflect best practice. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 10, 2021 Category: Consumer Health News Source Type: news

Comparison of qSOFA, SIRS, and NEWS scoring systems for diagnosis, mortality, and morbidity of sepsis in emergency department
This study was aimed to compare the quick Sequential Organ Failure Assessment (qSOFA), Systemic Inflammatory Response Syndrome (SIRS), and National Early Warning Score (NEWS) scoring systems for diagnosing sepsis and predicting mortality and morbidity.Patients and Methods: A prospective study was designed. qSOFA, SIRS, and NEWS scores were calculated at the admission. The diagnosis of sepsis was made with SOFA scoring initially. The morbidity and mortality of the patients were identified during follow-up. Also, the sensitivity, specificity, negative predictive value, and positive predictive value of three scoring systems w...
Source: Current Awareness Service for Health (CASH) - November 10, 2021 Category: Consumer Health News Source Type: news

A retrospective analysis of combat injury patterns and prehospital interventions associated with the development of sepsis - Carius BM, Bebarta GE, April MD, Fisher AD, Rizzo J, Ketter P, Wenke JC, Salinas J, Bebarta VS, Schauer SG.
BACKGROUND: Combat injury related wound infections are common. Untreated, these wound infections may progress to sepsis and septic shock leading to increased morbidity and mortality rates. Understanding infectious complications, patterns, progression, and ... (Source: SafetyLit)
Source: SafetyLit - November 8, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Thousands protest against Polish abortion laws
Some of the toughest restrictions in the EU are in the spotlight after woman dies of septic shock (Source: FT.com - Drugs and Healthcare)
Source: FT.com - Drugs and Healthcare - November 6, 2021 Category: Pharmaceuticals Source Type: news

Early Physical and Occupational Therapy and Discharge Disposition in Patients with Sepsis...American Congress of Rehabilitation Medicine (ACRM) Annual Conference (Virtual), September 2429, 2021
To explore whether implementing an early mobility protocol conducted by professionals from PT and or occupational therapy (OT) is associated with discharge location for a group of patients with sepsis, septic shock, or severe sepsis. A quasi-experimental study design was used with a non-equivalent post-test design. The data were collected for 3 months. Mid-sized Midwestern hospital. The population of the usual care group were 117 adult patients admitted to any unit with a diagnosis of sepsis, septic shock, or severe sepsis from February 1, 2019, through April 30, 2019. The early rehabilitation group were 96 patients admitt...
Source: Current Awareness Service for Health (CASH) - October 8, 2021 Category: Consumer Health News Source Type: news

Branched-Chain Amino Acids Can Predict Mortality in ICU Sepsis Patients
In conclusion, metabolomics using 1H NMR spectroscop y showed encouraging potential for personalized medicine in sepsis. BCAA was significantly lower in sepsis non-survivors and may be used as early biomarkers for outcome prediction. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 8, 2021 Category: Consumer Health News Source Type: news

Performance of scores in the prediction of clinical outcomes in patients admitted from the emergency service
Conclusion: quickSOFA showed by its pr acticality that it can be used clinically within the emergency services, bringing clinical applicability from the risk classification of patients for the early recognition of unfavorable outcomes. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 8, 2021 Category: Consumer Health News Source Type: news

Adherence to the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Does Not Lead to Improved Clinical Outcomes
A longitudinal study from a single healthcare system found that adherence to the Medicare Severe Sepsis and Septic Shock Early Management Bundle resulted in some changes in process measures, but did not lead to improvements in clinical outcomes. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 9, 2021 Category: Consumer Health News Source Type: news

Nursing Care for the Initial Resuscitation of Severe Sepsis Patients
Sepsis is recognized as a major health care problem worldwide. In the United States, mortality from severe sepsis and septic shock remains a serious health problem; yet, the early recognition of sepsis by nurses reduces can reduce mortality, morbidity, and long-term consequences of sepsis for patients. Improving the knowledge of nurses to first recognize the early signs of sepsis and then how to apply the most up-to-date evidence-based treatments can improve outcomes. Enhanced monitoring includes the use of computerized early warning systems to alert nurses of worrisome clinical patterns and promote the early recognition o...
Source: Current Awareness Service for Health (CASH) - September 9, 2021 Category: Consumer Health News Source Type: news

First-to-second antibiotic delay and hospital mortality among emergency department patients with suspected sepsis
Conclusions: First-to-second antibiotic delay of greater than one hour was associated with an increased risk of hospital death among patients meeting criteria for septic shock but not all patients with suspected sepsis. Tracking and improving first-to-second antibiotic delays may be considered in septic shock. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 9, 2021 Category: Consumer Health News Source Type: news

Improving Care of Skilled Nursing Patients: Implementation of Early Sepsis Recognition
An aging population with underlying health conditions, such as heart disease and diabetes, is at high risk for infections, including pneumonia, influenza, and coronavirus disease 2019 (COVID-19). In particular, the number of individuals in skilled nursing and long-term care facilities is increasing and older adults are at greatest risk. Research reveals these infections can lead to sepsis, septic shock, and death unless detected early through a sepsis screening process. The current quality improvement project demonstrates the capabilities of an early sepsis recognition screening tool in a skilled nursing facility and explo...
Source: Current Awareness Service for Health (CASH) - August 11, 2021 Category: Consumer Health News Source Type: news

Delays in Administration of the Second Antibiotic Dose in Patients With Severe Sepsis and Septic Shock
Conclusions: This single-center study found a 19.3% rate of significant delays in antibiotic second dose administration in patients with severe sepsis and septic shock. This study was not powered to identify differences in outcomes in patients with and without significant second dose delays. Additional large-scale studies are needed to investigate the impact of antibiotic second dose delays on outcomes in patients with sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 11, 2021 Category: Consumer Health News Source Type: news

Sepsis and Septic Shock
A Quick Lesson covering aetiology, facts and figures, risk factors, clinical presentation, assessment, treatment goals, red flags and guidance on what to tell the patient/ patient's family. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 11, 2021 Category: Consumer Health News Source Type: news

Antibiotic therapy in sepsis: No next time for a second chance! "
What is known and objective: Sepsis is a life ‐threatening organ dysfunction associated with a high rate of morbidity and mortality. Appropriate antibiotic therapy remains the cornerstone of sepsis and septic shock management. Comment: Although the early initiation of antimicrobial agents in the treatment of sepsis is widely acknowledged, the selection and adjustment to optimal dosage can be equally important. Since significant pathophysiological changes in the critically ill patients lead to altered pharmacokinetics of antibiotics, early consideration of pharmacokinetic/pharmacodynamic (PK/PD) properties is necessary fo...
Source: Current Awareness Service for Health (CASH) - August 11, 2021 Category: Consumer Health News Source Type: news

Association of ischemia modified albumin with mortality in qSOFA positive sepsis patients by sepsis-3 in the emergency department
This study aimed to investigate whether IMA was associated with short-term mortality in quick sequential organ failure assessment (qSOFA)-positive sepsis or septic shock patients screened by the sepsis management program.; Method: From September 2019 to April 2020, patients who arrived at the emergency departments with qSOFA-positive sepsis or septic shock were included in this retrospective observational study.; Results: Among 124 patients analyzed, IMA was higher in the non-surviving group than in the surviving group (92.6 ± 8.1 vs. 86.8 ± 6.2 U/mL, p (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 9, 2021 Category: Consumer Health News Source Type: news

Emerging mechanisms of immunocoagulation in sepsis and septic shock
Sepsis and septic shock driven by microbial infections are still among the most challenging health problems, causing 11 million deaths worldwide every year. How does the host's response to pathogen infections effectively restore homeostasis instead of precipitating pathogenic and potentially fatal feedforward reactions? Recently, there have been significant new advances in our understanding of the interface between mammalian immunity and coagulation ('immunocoagulation') and its impact on sepsis. In particular, the release and activation of F3 (the main initiator of coagulation) from and on myeloid or epithelial cells is f...
Source: Current Awareness Service for Health (CASH) - July 9, 2021 Category: Consumer Health News Source Type: news

Lower socioeconomic factors are associated with higher mortality in patients with septic shock
Background: Previous studies have explored the relationship between socioeconomic status and sepsis outcomes OBJECTIVES: The purpose of this investigation is to determine if race, ethnicity, economic stability, neighborhood environment, and access to health care are predictive of mortality in patients with septic shock.; Methods: Retrospective study of septic shock patients admitted to two medical centers.; Results: Caucasian patients had higher proportion of outpatient physician visits in the year prior to admission and were less likely to be Medicare or Medicaid beneficiaries. Thirty-day mortality was lower for the Cauca...
Source: Current Awareness Service for Health (CASH) - July 9, 2021 Category: Consumer Health News Source Type: news

Thiamine combined with vitamin C in sepsis or septic shock: a systematic review and meta-analysis
Conclusions: Despite widespread enthusiasm for thiamine combined with vitamin C for sepsis and septic shock, we only found an association with reduced SOFA score and time of vasopressor use. There was no association with in-hospital mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 9, 2021 Category: Consumer Health News Source Type: news

Treatment of suspected sepsis and septic shock in children with chronic disease seen in the pediatric emergency department
Conclusions: Study findings suggest pediatric patients with chronic disease with suspected sepsis or septic shock in the PED have a slower time to IVF administration but equivocal use of sepsis recognition tools compared to patients without chronic disease. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 9, 2021 Category: Consumer Health News Source Type: news

Evaluation of hospital nurse-to-patient staffing ratios and sepsis bundles on patient outcomes...Association for Professionals in Infection Control and Epidemiology, Annual Conference (Virtual), 28-30 June, 2021
• New York state was one of the first to require implementation of sepsis bundles. • Patient-to-nurse staffing ratios vary considerably across hospitals in New York. • Sepsis outcomes vary despite bundle requirements because of nurse staffing. • Requiring minimum nurse staffing along with se psis bundles may improve outcomes. Despite nurses'responsibilities in recognition and treatment of sepsis, little evidence documents whether patient-to-nurse staffing ratios are associated with clinical outcomes for patients with sepsis. Using linked data sources from 2017 including MEDPAR patient claims, Hospital C...
Source: Current Awareness Service for Health (CASH) - July 9, 2021 Category: Consumer Health News Source Type: news

Time to antibiotic administration: Sepsis alerts called in emergency department versus in the field via emergency medical services
Introduction: The Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) identifies patients with " severe sepsis " and mandates antibiotics within a specific time window. Rapid time to administration of antibiotics may improve patient outcomes. The goal of this investigation was to compare time to antibiotic administration when sepsis alerts are called in the emergency department (ED) with those called in the field by emergency medical services (EMS).; Methods: This was a multi-center, retrospective review of patients designated as sepsis alerts in ED or via EMS in the field, presenting to four community...
Source: Current Awareness Service for Health (CASH) - July 9, 2021 Category: Consumer Health News Source Type: news

The influence of nurse allocated triage category on the care of patients with sepsis in the emergency department: A retrospective review
' Gold standard'sepsis care encompasses the recognition and treatment of sepsis within one hour of emergency department (ED) presentation. Early treatment of patients with sepsis reduces mortality. The aim of this study was to examine the effect that the nurse allocated Australasian Triage Scale (ATS) Category allocation had on ED patient treatment for severe sepsis and septic shock. A two-year retrospective observational cohort study from a single major metropolitan ED, including all patients with severe sepsis or septic shock. Sixty patients were included in this study. Sepsis was recognised at triage for the majority of...
Source: Current Awareness Service for Health (CASH) - July 9, 2021 Category: Consumer Health News Source Type: news

Recognition in Emergency Department of Septic Patients at Higher Risk of Death: Beware of Patients without Fever
Conclusions : Physicians should bear in mind that fever is not a criterium for defining sepsis; according to our results, absence of fever upon presentation might be indicative of greater severity and diagnosis of sepsis should not be delayed. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 9, 2021 Category: Consumer Health News Source Type: news

Biomaterial vaccines ward off broad range of bacterial infections and septic shock
(Wyss Institute for Biologically Inspired Engineering at Harvard) Researchers at Harvard's Wyss Institute and John A. Paulson School for Engineering and Applied Sciences (SEAS) have developed a biomaterial-based infection vaccine (ciVAX) approach as a solution that could be broadly applied to challenges in infection medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 8, 2021 Category: Infectious Diseases Source Type: news

Effect of Ultrashort-Acting β-Blockers on Mortality in Patients With Sepsis With Persistent Tachycardia Despite Initial Resuscitation: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Review of 7 RCTs (n=613) reported significantly lower 28-day mortality with ultra-short acting β-blockers esmolol and landiolol vs placebo/no-intervention in patients with sepsis& septic shock (RR 0.68, 95% CI 0.54-0.85). Absolute risk reduction was 18.2% and NNT was 5.5. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 16, 2021 Category: Consumer Health News Source Type: news

Quantitative and Qualitative Assessments of Cholesterol Association With Bacterial Infection Type in Sepsis and Septic Shock
Background: Reduced cholesterol levels are associated with increased organ failure and mortality in sepsis. Cholesterol levels may vary by infection type (gram negative vs positive), possibly reflecting differences in cholesterol-mediated bacterial clearance. Methods: This was a secondary analysis of a combined data set of 2 prospective cohort studies of adult patients meeting Sepsis-3 criteria. Infection types were classified as gram negative, gram positive, or culture negative. We investigated quantitative (levels) and qualitative (dysfunctional high-density lipoprotein [HDL]) cholesterol differences. We used multivariab...
Source: Current Awareness Service for Health (CASH) - June 9, 2021 Category: Consumer Health News Source Type: news

Impact of the timeliness of antibiotic therapy on the outcome of patients with sepsis and septic shock
Conclusions: While two-thirds of sepsis studies reported an association between early administration of antibiotic therapy and patient outcome, the time-to-antibitiocs metrics varied significantly across studies and no robust time thresholds emerged. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 9, 2021 Category: Consumer Health News Source Type: news

Maternal Sepsis: presentation, course, treatment and outcomes
The current adult definition of sepsis and septic shock, as developed in 1992, does not adequately define sepsis in the pregnant and peripartum women due to the alteration of sepsis presentation in the maternal population. The purpose of this study was to determine potential causative factors for sepsis with the aim of prevention and reducing morbidity and mortality. Study Design and Methods: A descriptive observational design via a retrospective medical record review was used with a convenience sample of 22 women who were identified after admission as having sepsis. The setting was the labor and delivery unit of a large u...
Source: Current Awareness Service for Health (CASH) - June 9, 2021 Category: Consumer Health News Source Type: news

The role of eosinophils in sepsis and acute respiratory distress syndrome: a scoping review, Canadian journal of anaesthesia
Conclusion: Persistent peripheral eosinopenia is a marker of bacterial sepsis and is independently associated with poor outcomes. Bronchoalveolar lavage eosinophil counts are low in early-phase ARDS, but increase in late-phase ARDS, while elevated markers of eosinophil activity correlate with ARDS severity. Further studies understanding the mechanisms leading to eosinopenia in sepsis and increased eosinophil activity in ARDS are needed. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2021 Category: Consumer Health News Source Type: news

Machine learning methods to improve bedside fluid responsiveness prediction in severe sepsis or septic shock: an observational study, British journal of anaesthesia
Conclusions: Machine learning generated several models for predicting fluid responsiveness that were comparable with the haemodynamic response to PLR. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2021 Category: Consumer Health News Source Type: news

Predictive value of geriatric-quickSOFA in hospitalized older people with sepsis, BMC geriatrics
Background: QuickSOFA, a prognostic score proposed for patients with infection, has shown a poor predictive value in the geriatric population, probably because of the inappropriateness of the Glasgow Coma Scale (GCS) in assessing acute alteration of mental status in older patients. Indeed, the GCS might result chronically low in older patient with pre-existing cognitive disorders. The aim of this study was to develop an alternative quickSOFA (geriatric-quickSOFA), using the presence of delirium, assessed according to DSM-5 criteria, instead of GCS assessment, to predict mortality in hospitalized older patients with sepsis....
Source: Current Awareness Service for Health (CASH) - May 6, 2021 Category: Consumer Health News Source Type: news

Federal policy to reduce deaths from sepsis was mostly ineffective
(University of Pittsburgh) The first large-scale, multi-hospital evaluation of an " all or none " federal policy intended to improve results in sepsis patients finds that the guidelines are a wash - on average they neither helped nor hurt outcomes despite significant investments in their implementation. The findings indicate ways the Severe Sepsis and Septic Shock: Management Bundle, known as " SEP-1, " could be built upon and changed to potentially result in future improvements. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 19, 2021 Category: Infectious Diseases Source Type: news

Adherence to CMS SEP-1 measures found to have variable effects on patient outcomes
(American College of Physicians) A longitudinal study found that adherence to the Medicare Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) had variable effects on sepsis treatment and patient outcomes in its current iteration, which requires that a patient receive all measure components for their treatment to be considered compliant. The findings are published in Annals of Internal Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 19, 2021 Category: Infectious Diseases Source Type: news

Prognostic value of lactate levels and lactate clearance in sepsis and septic shock with initial hyperlactatemia: A retrospective cohort study according to the Sepsis-3 definitions, Medicine
This study evaluated the prognostic value of lactate levels and lactate clearance for 30-day mortality in patients with sepsis and septic shock diagnosed in the emergency department.We performed a retrospective cohort study of sepsis patients with initial lactate levels of ≥2 mmol/L. All patients met the Sepsis-3 definitions. The prognostic value of 6-hour lactate levels, 6-hour lactate clearance, 6-hour lactate metrics (≥2 mmol/L), and lactate clearance metrics ( (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news

Comparing mortality between positive and negative blood culture results: an inverse probability of treatment weighting analysis of a multicenter cohort, BMC Infectious Diseases
Conclusions: Culture-positive sepsis patients had comparable early mortality but worse late mortality than culture-negative sepsis patients in this cohort. Persistent Staphylococcal bacteremia may have contributed to the increased late mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news

Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19, Frontiers in immunology
Sepsis is a life-threatening systemic illness attributed to a dysregulated host response to infection. Sepsis is a global burden killing ~11 million persons annually. In December 2019, a novel pneumonia condition termed coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged and has resulted in more than 1,535,982 deaths globally as of 8 th December 2020. These two conditions share many pathophysiological and clinical features. Notably, both sepsis and COVID-19 patients experience consumptive thrombocytopenia, haemolytic anaemia, vascular microthrombosis, multi-o...
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news

Early Recognition and Management of Sepsis in the Elderly: A Case Study, Critical Care Nursing Quarterly
This article aims to inform clinicians and nurses of the importance of early recognition of subtle signs and symptoms and the management of sepsis in the elderly. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news

The pandemic has given me extra time with my teenage sons
It ’s been a tough time to be 17 or 18, but there have been some upsides, tooMy sons are 18 and 17. It was the younger ’s birthday this week and I made an awful cake that definitely breached myminimum cake standards (I hesitate to criticise Nigella, but there is such a thing as too much peanut butter). He looked a bit overwhelmed when we sang happy birthday, and I worried all day about him and his 17-year-old pandemic life, without access to the places and people that help being 17 make sense. There is nothing I can do about that, so I am fixating on the cake, sitting here wondering if I have time to make a rep...
Source: Guardian Unlimited Science - March 13, 2021 Category: Science Authors: Emma Beddington Tags: Life and style Family Children Parents and parenting Psychology Science Health & wellbeing Source Type: news

Adrecizumab: an investigational agent for the biomarker-guided treatment of sepsis, Expert opinion on investigational drugs 30(2): 95-102
Sepsis is a major health problem with a high incidence and mortality. ADM, a free-circulating peptide mainly expressed and secreted by vascular endothelial cells, shows vasodilatory properties and causes hypotension when present in higher concentrations during sepsis. Areas covered : Adrecizumab (ADZ) (HAM 8101) is a humanized targeted therapy directed against the N-terminus of adrenomedullin (ADM). ADZ inhibits excessive circulating sepsis-induced ADM and stimulates protective effects on the endothelial barrier, and decreases interstitial vasodilatory effects. ADZ demonstrated a promising safety profile in healthy subject...
Source: Current Awareness Service for Health (CASH) - March 4, 2021 Category: Consumer Health News Source Type: news

Pediatric infection and sepsis in five age subgroups: single-center registry, Wiener medizinische Wochenschrift,171(1-2): 29-35
Conclusion: With this registry, children divided into five age subgroups with infection or sepsis were evaluated and treatment strategies were examined. We have shown that our findings on children treated in our pediatric intensive care unit conform with current literature about pediatric sepsis. In addition to maintaining strict hygiene standards, optimal aspects of sepsis care should be stringently observed, such as the quick administration of empirical broad-spectrum antibiotics, initial adequate fluid resuscitation, and a reliable and frequent routine of source control. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 4, 2021 Category: Consumer Health News Source Type: news

Sepsis and Septic Shock Definitions in Patients With Cancer Admitted in ICU, Journal of Intensive Care Medicine 36(34): 255-261
Conclusion: The new definition of sepsis and septic shock is applicable in an ICU oncological population with the same reliability as in the general population. The SOFA score is more accurate than qSOFA and SIRS criteria to predict hospital mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 3, 2021 Category: Consumer Health News Source Type: news