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Quickly Recognizing a Life-Threatening Infection
Careful assessment helps recognize life-threatening infection You and an engine company arrive to a single family, two-story home. You're met at the door by a male in his late 20s. He says he called you after coming to check on his 58-year-old father after he missed their tee time. He found his father, Matt, lying in bed and unresponsive. He leads you upstairs to his father's bedroom and tells you his mom died two years ago and Matt now lives by himself. He isn't aware of his dad having any significant medical history. As you enter the bedroom you see Matt sleeping. His breathing is rapid and deep. His skin looks flushed f...
Source: JEMS Patient Care - October 30, 2017 Category: Emergency Medicine Authors: Dennis Edgerly, EMT-P Tags: Patient Care Columns Source Type: news

Angiotensin II: New Hope for Treating Septic Shock? Angiotensin II: New Hope for Treating Septic Shock?
Dr Martin reviews research on the safety and efficacy of angiotensin II for septic shock.Medscape Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 27, 2017 Category: Consumer Health News Tags: Critical Care Viewpoint Source Type: news

Transport of Sepsis Patients
This was the first large multi-center study in a public health system evaluating the effect of EMS transport on the management and outcome of patients who were diagnosed with severe sepsis or septic shock in the ED. As expected, triage to emergency physician time, triage to admission time, triage to declaration time, and triage to bundle compliance time were all shorter for patients who arrived by EMS. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 19, 2017 Category: Consumer Health News Source Type: news

A Better Way to Detect Sepsis in Kids in the ED A Better Way to Detect Sepsis in Kids in the ED
CHOP researchers, led by Dr Fran Balamuth, have developed a sepsis alert system that misses very few children presenting to the ED with septic shock.CHOP Expert Commentary (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 9, 2017 Category: Consumer Health News Tags: Pediatrics Commentary Source Type: news

Septic Shock: Does Early, Goal-Directed Therapy Help? Septic Shock: Does Early, Goal-Directed Therapy Help?
A new meta-analysis from the New England Journal of Medicine clarifies whether there are any benefits from early, goal-directed therapy for sepsis.Medscape Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 29, 2017 Category: Consumer Health News Tags: Critical Care Viewpoint Source Type: news

Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Task Force recently introduced a new clinical score termed quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA) for identification of patients at risk of sepsis outside the intensive care unit (ICU). This research article concludes that in patients with suspected infection who eventually required admission to the ICU, qSOFA calculated before their ICU admission had greater accuracy than SIRS for predicting mortality and ICU-free days. However, it may be less clear whether qSOFA is also better than SIRS criteria for predicti...
Source: Current Awareness Service for Health (CASH) - September 21, 2017 Category: Consumer Health News Source Type: news

Making connections: Bonded by short bowel syndrome
At the top of the dual slide, 4-year-old Brayden Austin is buzzing with energy, excited to go careening down to the bottom. Yet he waits patiently until a towheaded boy joins him on the neighboring chute. Two-year-old Camden Glover is a little nervous. But Brayden grabs his hand and the pair sails to the ground together, squealing with delight. It’s a typical playground scene, but also an apt metaphor for the boys’ special connection. The two children — one from Maine, one from Tennessee — have a close friendship. But they might never have met if not for one life-threatening event. Parallel lives &...
Source: Thrive, Children's Hospital Boston - August 28, 2017 Category: Pediatrics Authors: Jessica Cerretani Tags: Diseases & Conditions Our Patients’ Stories Center for Advanced Intestinal Rehabilitation Dr. Bram Raphael Dr. Mark Puder intestinal malrotation Omegaven short bowel syndrome (SBS). TPN Source Type: news

Systolic BP Variability in Severe Sepsis or Septic Shock Systolic BP Variability in Severe Sepsis or Septic Shock
Is systolic blood pressure variability associated with clinical outcomes in septic patients?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 2, 2017 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Medicare List of Appropriate Antibiotics for Sepsis Needs Revision Medicare List of Appropriate Antibiotics for Sepsis Needs Revision
Several antibiotics listed in the tables for the Center for Medicare and Medicaid Services (CMS) performance measure for the Early Management Bundle, Severe Sepsis/Septic Shock (SEP-1) are not appropriate and their use is inconsistent with prudent antimicrobial stewardship, according to an expert work group.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - August 1, 2017 Category: Intensive Care Tags: Infectious Diseases News Source Type: news

Procalcitonin as a diagnostic biomarker for septic shock and bloodstream infection in burn patients from the Formosa Fun Coast dust explosion - Wu RX, Chiu CC, Lin TC, Yang YS, Lee Y, Lin JC, Chang FY.
BACKGROUND/PURPOSE: Infection is the most common cause of death following burn injury. The study was conducted to compare the diagnostic value of serum procalcitonin (PCT) with the other current benchmarks as early predictors of septic shock and bloodstrea... (Source: SafetyLit)
Source: SafetyLit - July 16, 2017 Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

Evolving Sepsis Criteria and New Management Guidelines Hold Lessons for PA/LTC
PHOENIX — The recently published Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) and newly updated Surviving Sepsis Campaign international guidelines for management emphasize the need for earlier recognition and more timely management of sepsis — and not only in the hosp ital setting. (Source: Caring for the Ages)
Source: Caring for the Ages - June 29, 2017 Category: Health Management Authors: Christine Kilgore Source Type: news

Drug Shortages and Septic Shock: Not a Good Mix Drug Shortages and Septic Shock: Not a Good Mix
According to a new study, patients with septic shock had worse outcomes during the 2011 norepinephrine shortage.Medscape Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 28, 2017 Category: Consumer Health News Tags: Critical Care Viewpoint Source Type: news

Readily available drug cocktail can help prevent sepsis shock and death
(Elsevier) Even in advanced medical settings, sepsis is still very dangerous and accounts for over 400,000 deaths annually in the US alone. While new drugs are in development, a group of researchers has determined that a combination of intravenous vitamin C, corticosteroids (a steroid), and thiamine (vitamin B) may be effective in preventing progressive organ dysfunction and reducing the number of deaths from severe sepsis and septic shock. Their findings are published in the June issue of CHEST. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - June 26, 2017 Category: International Medicine & Public Health Source Type: news

Readily available drug cocktail may help prevent sepsis shock and death
(Elsevier) Even in advanced medical settings, sepsis is still very dangerous and accounts for over 400,000 deaths annually in the US alone. While new drugs are in development, a group of researchers has determined that a combination of intravenous vitamin C, corticosteroids (a steroid), and thiamine (vitamin B) may be effective in preventing progressive organ dysfunction and reducing the number of deaths from severe sepsis and septic shock. Their findings are published in the June issue of CHEST. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 26, 2017 Category: International Medicine & Public Health Source Type: news

Protective Association Identified for Asthma Against Sepsis
Decreased risk for hospital mortality, septicemia, sepsis, severe sepsis, and septic shock (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - June 23, 2017 Category: Respiratory Medicine Tags: Infections, Internal Medicine, Critical Care, Pathology, Pulmonology, Journal, Source Type: news

Dangerous unproven treatments for ‘ chronic Lyme disease ’ are on the rise
An increasing number of Americans with medically ambiguous symptoms are being misdiagnosed with “chronic Lyme disease” and prescribed dangerous and often expensive treatments that do not work, according to a new report. In some instances, patients have died after receiving intensive, long-term and inappropriate courses of intravenous antibiotics that led to septic shock. In other […]Related:Fever during pregnancy may increase autism risk in offspringUNC oncologist and researcher named head of the National Cancer InstituteZika risk for birth defects drops for each trimester, CDC finds (Source: Washington ...
Source: Washington Post: To Your Health - June 15, 2017 Category: Consumer Health News Source Type: news

Severe Sepsis and Septic Shock National Clinical Audit 2016/17
This audit of 13,129 adults arriving in 196 emergency departments showed that 44% of patients with sepsis receive antibiotics within one hour of arrival. The Royal College of Emergency Medicine makes recommendations for organisation sepsis leads for continuing improvement. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 8, 2017 Category: Consumer Health News Source Type: news

Severe sepsis and septic shock: clinical audit 2016/17
A report from the Royal College of Emergency Medicine finds that there has been an improvement in the proportion of patients receiving the best care for severe sepsis and septic shock, but that improvements are needed to make treatment available faster. (Source: NHS Networks)
Source: NHS Networks - June 7, 2017 Category: UK Health Source Type: news

Man dies from sepsis after swimming with new tattoo
(Natural News) Artistic and stunning though they may be, tattoos are still open wounds that need to be taken special care of — a fact that many newly-tattooed people tend to ignore at their own risk. Such was the case for an unidentified 31-year old man, who had reportedly died from septic shock after his... (Source: NaturalNews.com)
Source: NaturalNews.com - June 2, 2017 Category: Consumer Health News Source Type: news

HMGB1 may be linked to immunosuppression in patients who survive septic shock
(Federation of American Societies for Experimental Biology) A study published online in the Journal of Leukocyte Biology reveals that in the late stage of sepsis, HMGB1, or the 'high mobility group box 1' protein, might be a target for future therapies because the protein plays a key role in the development of post-sepsis immunosuppression and sepsis-induced dysfunction of neutrophils. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 1, 2017 Category: International Medicine & Public Health Source Type: news

Severe Sepsis and Septic Shock Clinical Audit 2016/17
This National Report covers an audit, which shows an improvement in the proportion of patients receiving the best care for severe sepsis and septic shock, but that improvements are needed to make treatment available faster (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 31, 2017 Category: Consumer Health News Source Type: news

RCEM audit finds sepsis care in UK Emergency Departments is improving
This audit shows an improvement in the proportion of patients receiving the best care for severe sepsis and septic shock, but that improvements are needed to make treatment available faster (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 30, 2017 Category: Consumer Health News Source Type: news

Sewage Saved This Man's Life. Someday It Could Save Yours.
When Thomas Patterson woke up from a two-month coma in March 2016, he learned two things he couldn’t believe: Donald Trump was soon to become the Republican nominee for president, and his wife, Steffanie Strathdee, had saved him from dying of an antibiotic-resistant superbug by injecting him with viruses harvested from sewage. It took a lot of convincing for him to accept these weren’t just more hallucinations. Patterson and Strathdee met while serving on a National Institutes of Health grant review panel almost 16 years ago. Strathdee doesn’t usually find review panels a riveting experience, but when she...
Source: Healthy Living - The Huffington Post - May 11, 2017 Category: Consumer Health News Source Type: news

Sewage Saved This Man's Life. Someday It Could Save Yours.
This article has been updated to amend overstatements of the length of time it took the Texas A&M team to secure the phages they sent to Patterson, as well as the number of researchers to whom Strathdee reached out. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website. (Source: Science - The Huffington Post)
Source: Science - The Huffington Post - May 11, 2017 Category: Science Source Type: news

Novel molecular signal for triggering septic shock identified
The mechanism by which cellular signaling transduction network is exquisitely controlled in mediating innate immune response such as sepsis by the enzyme IPMK (Inositol polyphosphate multikinase) essential for inositol biosynthesis metabolism, report scientists. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 4, 2017 Category: Science Source Type: news

KAIST team identifies the novel molecular signal for triggering septic shock
(The Korea Advanced Institute of Science and Technology (KAIST)) Professor Seyun Kim's team from KAIST reported the mechanism by which cellular signaling transduction network is exquisitely controlled in mediating innate immune response such as sepsis by the enzyme IPMK (Inositol polyphosphate multikinase) essential for inositol biosynthesis metabolism. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 4, 2017 Category: Global & Universal Source Type: news

About New York: A Boy ’ s Life Is Lost to Sepsis. Thousands Are Saved in His Wake.
In 2012, Rory Staunton, 12, died from septic shock. Five years later, a study shows that fewer people are dying from the condition. (Source: NYT Health)
Source: NYT Health - April 14, 2017 Category: Consumer Health News Authors: JIM DWYER Tags: Sepsis Health Department (NYS) New York University Langone Medical Center Zucker, Howard A New York State Source Type: news

Despite ongoing meningitis outbreak, vaccinations low among gay men, study shows
Despite a yearlong outbreak of invasive meningococcal disease in Southern California primarily affecting gay and bisexual men, less than 27 percent of men who have sex with men in Los Angeles County have been vaccinated for meningitis.The findings released today by the California HIV/AIDS Policy Research Center in collaboration with the UCLA Luskin School of Public Affairs, the Los Angeles LGBT Center and AIDS Project Los Angeles Health call for more education about the disease and more places offering immunization throughout Southern California at venues where gay and bisexual men socialize.More than 500 men were intervie...
Source: UCLA Newsroom: Health Sciences - March 30, 2017 Category: Universities & Medical Training Source Type: news

Confirmed: Aggressive Septic Shock Protocol Does Not Reduce Deaths (CME/CE)
(MedPage Today) -- Meta-analysis finds no benefit even among sickest patients (Source: MedPage Today Emergency Medicine)
Source: MedPage Today Emergency Medicine - March 23, 2017 Category: Emergency Medicine Source Type: news

Norepinephrine Shortage Tied to Increase in Septic Shock Deaths Norepinephrine Shortage Tied to Increase in Septic Shock Deaths
A shortage several years ago of norepinephrine used to treat septic shock was tied to an increase in deaths among patients with the condition, a new study shows.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - March 22, 2017 Category: Pathology Tags: Critical Care News Source Type: news

Septic Shock Deaths Increased with Hospital Drug Shortage (CME/CE)
(MedPage Today) -- Study finds strong association between norepinephrine shortage and deaths (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - March 22, 2017 Category: Consumer Health News Source Type: news

Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department
This piece of research has led to a practice changing update on DynaMed Plus. It concludes that among patients presenting to the emergency department with suspected infection, the use of qSOFA resulted in greater prognostic accuracy for in-hospital mortality than did either SIRS or severe sepsis. These findings provide support for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) criteria in the emergency department setting. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 22, 2017 Category: Consumer Health News Source Type: news

Drug shortage in 2011 tied to increased deaths
(Reuters Health) - - A shortage several years ago of a drug used to treat a deadly infection known as septic shock was tied to an increase in deaths among patients with the condition, a new study shows. (Source: Reuters: Health)
Source: Reuters: Health - March 21, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Shortage of drug to treat low blood pressure from septic shock associated with increased deaths
Patients with septic shock admitted to hospitals affected by the 2011 shortage of the drug norepinephrine had a higher risk of in-hospital death, according to a study. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 21, 2017 Category: Science Source Type: news

Survival Benefit and Cost Savings of a 3-Hour Sepsis Bundle Survival Benefit and Cost Savings of a 3-Hour Sepsis Bundle
Find out about the survival and cost benefits associated with a three-hour sepsis bundle for severe sepsis and septic shock.Critical Care Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 16, 2017 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

Adrenomed AG: Adrecizumab is Safe, Well-tolerated and Shows Additional...
Phase-I study demonstrates excellent tolerability and safety of Adrecizumab in healthy subjects. Adrenomed AG plans second Phase-II study in acute heart failure, in addition to septic shock.(PRWeb March 08, 2017)Read the full story at http://www.prweb.com/releases/2017/03/prweb14127485.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - March 8, 2017 Category: Pharmaceuticals Source Type: news

Septic shock surveillance should be based on clinical data, not billing codes
(Elsevier Health Sciences) Tracking sepsis rates and outcomes is challenging because it is a heterogeneous syndrome without a definitive 'gold standard' test. In the February issue of CHEST, investigators compared the effectiveness of claims-based surveillance using ICD-9 codes with clinical-based data and specific diagnostic parameters. Their findings suggest that surveillance based on clinical criteria is a more reliable way to track cases of septic shock. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 13, 2017 Category: Infectious Diseases Source Type: news

Orexin as a potential drug for treating septic shock
Sepsis is a life-threatening condition due to excessive immune responses to infection that damages the patient's own tissues and organs. In septic shock, the severest stage of sepsis, the blood pressure drops to a dangerously low level, often leading to multiple organ failure and death. To date, there is no effective therapy yet available for septic shock. Recent findings may be a breakthrough in developing a silver bullet for the treatment of septic shock. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 9, 2017 Category: Science Source Type: news

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock updated
This updated guideline was produced by 55 international experts; with the most important changes and advances in the guideline being in the domains of initial resuscitation and antibiotic therapy. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 1, 2017 Category: Consumer Health News Source Type: news

News: Hydrocortisone Fails to Prevent Septic Shock
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - February 1, 2017 Category: Emergency Medicine Tags: News Source Type: news

Management of Sepsis and Septic Shock
This Synopsis of Clinical Guidelines gives a summary of the clinical problem, examines the evidence base, looks at benefits and harms and outlines areas in need of future study or ongoing research (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 26, 2017 Category: Consumer Health News Source Type: news

Surviving Sepsis Guidelines: A Continuous Move Toward Better Care of Patients With Sepsis
The updated guideline was generated by 55 international experts representing 25 international organizations involved in the care of patients with sepsis and providing 93 recommendations on early management of sepsis and septic shock. There are numerous major advances in the revision of the guidelines. Among the various topics covered, initial resuscitation and antibiotic therapy are the domains in which the most important changes and advances were made. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 26, 2017 Category: Consumer Health News Source Type: news

Sepsis Gets an Upgrade
Conclusion “These updated definitions and clinical criteria should clarify long-used descriptors and facilitate earlier recognition and more timely management of patients with sepsis or at risk of developing it. This process, however, remains a work in progress. As is done with software and other coding updates, the task force recommends that the new definition be designated Sepsis-3. With the 1991 and 2001 iterations being recognized as Sepsis-1 and Sepsis-2, respectively, to emphasize the need for future iterations.” Clinical Take Home Points Sepsis = Life-threatening organ dysfunction caused by a dysregulat...
Source: EPMonthly.com - December 31, 2016 Category: Emergency Medicine Authors: Matt McGahen Tags: Uncategorized Source Type: news

Pro Bono: Stay Current on EMS Standards of Care to Avoid Liability Risk
Medical care is advancing at a very rapid pace. New technologies, new medications, and new or modified patient care procedures affect our practice of EMS as well as our potential liability. We must keep up with what's happening in the world of evidence-based healthcare. The public expects us to drive the standard of care forward and provide the best possible healthcare with the latest technologies and procedures. EMS agencies that don't keep up with current research and improvements in patient care procedures will not only be left in the dust, but could also end up under a pile of litigation. It's not just new technologies...
Source: JEMS Administration and Leadership - December 30, 2016 Category: Emergency Medicine Authors: Stephen R. Wirth, Esq., EMT-P Tags: Columns Administration and Leadership Source Type: news

Septic Shock With No Diagnosis at 24 Hours Septic Shock With No Diagnosis at 24 Hours
Do outcomes differ between early- and late-confirmed cases of septic shock?Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 22, 2016 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

A Qualitative feasibility study to inform fluids in shock (FISH) A Pilot randomised controlled Trial of Fluid Bolus Therapy in Septic Shock
There is increasing evidence that fluid overload may be associated with harm in paediatric critical illness. Fluids in Shock (FiSH) is a combined feasibility and pilot randomised controlled trial (RCT) to determine if restrictive fluid bolus therapy (10  ml/kg) is more beneficial than current recommended fluid bolus therapy (20 ml/kg) in the resuscitation of children with presumed septic shock. This qualitative feasibility study aims to explore: acceptability of the proposed pilot RCT, including the prospect of research without prior consent (R WPC); other potential barriers to conduct of the pilot RCT; participant inf...
Source: Current Awareness Service for Health (CASH) - December 19, 2016 Category: Consumer Health News Source Type: news

Severe sepsis and septic shock: Mayo Clinic Radio Health Minute
In this Mayo Clinic Radio Health Minute, we look at the progression of sepsis with Dr. Steve Peters. To listen, click the link below. Severe Sepsis and Septic Shock (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - December 11, 2016 Category: Databases & Libraries Source Type: news