Fight Aging! Newsletter, May 17th 2021
This study is consistent with previous evidence showing that inflammaging, or age-related inflammation, is naturally heightened in the nervous system. Moreover, the authors disproved their hypothesis that anti-inflammatory microglia-specific genes are responsible for the elevated inflammatory response in aged brains since the expression of anti-inflammatory mediators was elevated in middle-aged brains following infection. Thus, the cause for the increase in pro-inflammatory genes remains to be elucidated.
Mixed Results in Animal Studies of Gene Therapy Targeting Axonal Regrowth
https://www.fightaging.org/archives/2021/05/mixed-results-in-animal-studies-of-gene-therapy-targeting-axonal-regrowth/
Researchers here attempted a combination gene therapy using BDNF and TrkB in order to provoke growth of axons in the mouse optic nerve and brain. The hope is to produce enough repair and regrowth to outpace for a time the disease process that causes damage. This seemed to have positive results in the optic nerve, but less so when applied to a mouse model of tauopathy. The regenerative medicine community might argue that sufficiently comprehensive regenerative will help, and functional recovery following treatment is a matter of the balance between degree of regeneration versus degree of harm caused by the disease process. It remains the case that addressing the causes of the condition may also be necessary to achieve positive results in patients.
A common f...
Source: Fight Aging! - Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More News: Accidents | Age-Related Macular Degeneration (AMD) | Alcoholism | Alzheimer's | Biochemistry | Biology | Biotechnology | Brain | Brain Cancers | Cancer | Cancer & Oncology | Cardiology | Cardiovascular | Chemotherapy | Child Development | Children | Chronic Kidney Disease | Coronary Heart Disease | Databases & Libraries | Dementia | Diabetes | Dialysis | Education | Endocrinology | Environmental Health | Eyes | Fish | Gastroschisis Repair | Gene Therapy | Genetics | Glaucoma | Health Management | Heart | Heart Disease | Heart Transplant | Herbs | HIV AIDS | Hypertension | Immunotherapy | Induction of Labor | Insect Bites & Stings | International Medicine & Public Health | Ischemic Stroke | Italy Health | Kidney Transplant | Kidney Transplantation | Learning | Malaria | Marketing | Melanoma | Men | Minerals | Mitochondria | Mitochondrial Disease | Molecular Biology | Neurology | Neuroscience | Norway Health | Nutrition | Occupational Health | Pathology | Physiology | Prostate Cancer | Reflex Sympathetic Dystrophy | Reproduction Medicine | Research | Science | Skin Cancer | Smokers | Spinal Cord Injury | Sports Medicine | Statistics | Stem Cell Therapy | Stem Cells | Stroke | Study | Toxicology | Transplants | Universities & Medical Training | Urology & Nephrology | USA Health | Women