Fight Aging! Newsletter, June 24th 2019
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age. Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, and 10.8 for never, former, and current smokers, respectively. Significant effects on survival were also found for physical inactivity, low income, being unmarried, high blood pressure, and high cholesterol. For men with 0-4 of these risk factors, the percentages reaching 90 years were 33.3, 24.9, 12.4, 14.4, and 1.5, respectively. Quitting smoking and increasing physical activity before 55 years of age improved survival significantly. The main finding of this study is the huge reduction in observed life length for men with two or more of the risk factors identified in this study, i.e., current smoking, physical inactivity, low income, being unmarried, high blood pressure, or high total cholesterol. Reported in adult mid-life, these risk factors started to take their toll as early as approximately 55 years of age, and over time, more and more lives we...
AbstractGene therapy has drawn great attention in the treatments of many diseases, especially for cardiovascular diseases. However, the development of gene carriers with low cytotoxicity and multitargeting function is still a challenge. Herein, the multitargeting REDV-G-TAT-GNLS peptide was conjugated to amphiphilic cationic copolymer poly( ε-caprolactone-co-3(S)-methyl-morpholine-2,5-dione)-g-polyethyleneimine (PCLMD-g-PEI) via a heterobifunctional orthopyridyl disulfide-poly(ethylene glycol)-N-hydroxysuccinimide (OPSS-PEG-NHS) linker to prepare PCLMD-g-PEI-PEG-REDV-G-TAT-G-NLS copolymers with the aim to develop t...
CONCLUSION: In hypertensive and diabetic patients, higher OPG values were associated with impaired LA function assessed by 2D-STE. In this high-risk patient group, serum OPG can be used as a risk predictor for LA mechanical dysfunction. PMID: 32462219 [PubMed - as supplied by publisher]
Publication date: Available online 29 May 2020Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Khushdeep Bandesh, Dwaipayan Bharadwaj
Publication date: October 2020Source: Journal of Environmental Chemical Engineering, Volume 8, Issue 5Author(s): Jôse Raymara Alves Lima, Douglas Lira de Farias, Thalles Henrique Santos Menezes, Rhayza Victoria Matos Oliveira, Iris Amanda Alves Silva, Graziele da Costa Cunha, Luciane Pimenta Cruz Romão
Publication date: October 2020Source: Journal of Environmental Chemical Engineering, Volume 8, Issue 5Author(s): Ahmed R. Abdellah, Hani Nasser Abdelhamid, Abu-Bakr A.A.M. El-Adasy, Ahmed A. Atalla, Kamal I. Aly
Publication date: Available online 29 May 2020Source: Arabian Journal of ChemistryAuthor(s): Mohamed A. Betiha, Gehad G. Mohamed, Nabel A. Negm, Modather F. Hussein, Hany E. Ahmed
To quantitate left ventricular mass index (LVMI) and correlate it with inflammation, insulin resistance (IR) and serum androgen levels among nonobese normotensive women with polycystic ovary syndrome (PCOS).
Uterine fibroids (leiomyoma) are benign monoclonal neoplasms of the myometrium and represent the most common tumors in women worldwide. Tumors occur in ∼77% of women overall and are clinically manifest in ∼25% by age 45 years. Although benign, these tumors are nonetheless associated with significant morbidity; they are the primary indication for hysterectomy, and a major source of gynecologic and reproductive dysfunction, ranging from profuse m enstrual bleeding and pelvic pain to infertility, recurrent miscarriage, and preterm labor.
To study whether patients exhibiting poor ovarian response have abnormal levels of serum insulin-like growth factor (IGF)-1 on cycle day 2 when compared with age-matched normal and high responders.
Authors: Bilkhu R, Billè A Abstract The coronavirus 2019 (COVID-19) pandemic has caused significant mortality around the world and the focus has been on reducing the number of infections. In order not to compromise treatment of oncology patients, reducing the number of patients with COVID-19 undergoing treatment is mandatory. We reviewed the experience of the National Institute of Cancer in Milan and compared it with our experience. PMID: 32462984 [PubMed - as supplied by publisher]
More News: Alzheimer's | Antidoxidants | Atrial Fibrillation | Biochemistry | Biomedical Science | Biotechnology | Brain | Brain Cancers | Calcium | Cancer | Cancer & Oncology | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Chemistry | Cholesterol | Chronic Pain | Clinical Trials | Cold Sores | Coronary Artery Bypass Graft | Dementia | Depression | Diabetes | Diabetes Type 2 | Diets | Disability | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Epithelial Cancer | Expenditures | Fruit | Funding | Gastroschisis Repair | Gene Therapy | Genetics | Health Management | Heart | Heart Attack | Heart Failure | Heart Valve Surgery | Herpes | High Fat | Hormones | Huntington's Disease | Hypertension | Insulin | Ischemic Stroke | Laboratory Medicine | Liver | Lyme Disease | Men | Mitochondria | Mitochondrial Disease | Molecular Biology | Nanotechnology | Neurology | Neuroscience | Neurosurgery | Norway Health | Nutrition | Obesity | Oral Cancer | Organic | Orthopaedics | Osteoarthritis | Pain | Parkinson's Disease | Pathology | Peripheral Vascular Disease (PVD) | Physiology | Profits and Losses | Pulmonary Thromboembolism | Research | Respiratory Medicine | Science | Sleep Disorders | Sleep Medicine | Smokers | Sodium Chloride | Sports Medicine | Statistics | Stem Cell Therapy | Stem Cells | Stroke | Study | Sugar | Suicide | Thrombosis | Toxicology | Training | UK Health | Universities & Medical Training | Urology & Nephrology | Vitamin B3