Vitamins: stop taking the pills

This article was corrected on 7 June 2013. During editing, a line in the fifth from last paragraph, beginning 'Another example is St John's wort…' was accidentally transposed, leading to the suggestion that serotonin was a medicine rather than a brain chemical.Alternative medicineHealth &wellbeingHealthCancerCancerMedical researchPharmaceuticals © 2013 Guardian News and Media Limited or its affiliated companies. All rights reserved. | Use of this content is subject to our Terms &Conditions | More Feeds    
Source: Guardian Unlimited Science - Category: Science Tags: The Guardian Depression Pharmaceuticals industry Health Medical research & wellbeing Society Extracts Features Cancer Life and style Alternative medicine Science Source Type: news

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Publication date: Available online 21 March 2019Source: MethodsAuthor(s): Navoun Silué, Endrei Marcantonio, F-X Campbell-ValoisAbstractShigella spp. are enterobacteria that invade human colonic mucosal cells using their Type Three Secretion Apparatus (T3SA). Shigella spp. possess a large plasmid that encodes most of its virulence factors and has been the focus of seminal work that defined the T3SA regulon. Thus, a global assessment of the transcriptional response regulated by the T3SA has been lacking. Herein we used RNA-Seq to identify genes that are differentially expressed when the T3SA is active (on-state) versu...
Source: Methods - Category: Molecular Biology Source Type: research
This study can provide basic data and theoretical foundation for the separation process.
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 21 March 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Pourseyed Aghaei Fatematossadat, Mahnaz Mohammadi, S. Ehsan RoozmehAbstractIn this paper, we study magnetic and structural properties of silver and gold-coated iron nanoparticle as novel drug delivery systems for the two commercially famous cancer treatment drugs, using the density functional theory (DFT) computations.Our calculations show that silver and gold-coated iron nanoparticle have magnetization and the magnetic moment of the Fe atom in the Fe@(Ag/Au)n core-shells saturated to a value of about 3 μB. Thus...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
ConclusionOur study suggests a VDR-mediated metabolic cross-talk between gut and adipose tissue, which significantly contributes to systemic lipid homeostasis. These results have important implications for use of the intestinal VDR as a therapeutic target for obesity and associated disorders.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 21 March 2019Source: Redox BiologyAuthor(s): Tsung-Ming Lee, Horng-Jyh Harn, Tzyy-Wen Chiou, Ming-Hsi Chuang, Chun-Hung Chen, Chi-Hsuan Chuang, Po-Cheng Lin, Shinn-Zong LinAbstractLeft ventricular hypertrophy (LVH) in hypertension has prognostic significance on cardiovascular mortality and morbidity. Recently, we have shown that n-butylidenephthalide (BP) improves human adipose-derived stem cell (hADSC) engraftment via attenuated reactive oxygen species (ROS) production. This prompted us to investigate whether remote transplantation of BP-pretreated hADSCs confers attenuated LVH at an est...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: Available online 21 March 2019Source: Carbohydrate PolymersAuthor(s): Shuo Tang, Ting Wang, Caoxing Huang, Chenhuan Lai, Yimin Fan, Qiang YongAbstractA highly branched arabinogalactan isolated from Larix principis-rupprechtii and subjected to sulfation derivatization to promote their antitumor bioactivity. Several structural features of the sulfated arabinogalactans (S-LAG) were investigated: molecular weight, monosaccharide constitution, and chemical structures. Spectral analysis indicated that sulfate groups were successfully introduced on arabinogalactan. Sulfated products showed different degrees of s...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 21 March 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Tong Tong, Zhihui Liu, Hua Zhang, Jinglei Sun, Dongxia Zhang, Feng Wang, Dechao Miao, Yong ShenAbstractAccumulating evidence shows that genetic polymorphism of the vitamin D receptor (VDR) gene is associated with intervertebral disc degeneration (IDD), implying that VDR may be involved in the pathogenesis of IDD. However, the exact relationship between VDR and IDD remains unknown. The aim of this study was to investigate the age-dependent expression of VDR in rat intervertebral discs and to determine ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 22 March 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Tania Molina-Jiménez, Martín Jiménez-Tlapa, Malinalli Brianza-Padilla, Rossana Citlali Zepeda, Marisela Hernández-González, Herlinda Bonilla-JaimeAbstractAdministering clomipramine during the early days of life induced several behavioral and neurochemical alterations in adult male rats, which resemble major depression disorder. The alterations affected sexual performance, which is considered a reward-seeking behavior regulated by the dopaminergic system. Given that estrogen receptors a...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Publication date: Available online 21 March 2019Source: MitochondrionAuthor(s): Hamza El Hadi, Roberto Vettor, Marco RossatoAbstractCardiovascular disease is the leading cause of diabetes-related morbidity and mortality. It is widely accepted that heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Mitochondria are the center of fatty acid (FA) and glucose metabolism and thus are likely to be impacted by impaired metabolism associated with diabetes. Although the cause of this increased heart failure risk is multifactorial, increasing evidence points toward...
Source: Mitochondrion - Category: Biochemistry Source Type: research
ConclusionsO-GlcNAcylation significantly modified STRA6 and RALDH1, suppressed RBP4 binding activity, and disrupted retinol signals in the kidney of diabetes.General significanceThis study first indicates that STRA6-retinol signals were directly disrupted by O-GlcNAcylation in diabetic kidney.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
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