Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective

Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; Hema et al., 2017; Lindsay et al., 2017). Exposure to bacteria, virus, toxins, pesticides, stress, life styles changes, sleep disorders, etc, all (in combination or alone) affecting the circadian clock and increase vulnerability to head and neck pathologies (Hooven et al., 2009; LeGates et al., 2014; Cui et al., 2016; Potter et al., 2016; Koch et al., 2017; Kopp et al., 2017). Omics approaches need to be combined with tests and biosensor data for each patient to get most out of them. Recently, there was noted a growing interest on clinical testing of the ability of drugs/small molecules to reset the circadian clock and treat diseases, such as diabetes and cancer (Antoch and Chernov, 2009; He and Chen, 2016; Tamai et al., 2018). Combined omics will be needed to monitor the effects of drugs and individual health outcome. Not least, saliva may become a gold stand...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

Related Links:

Publication date: Available online 24 May 2019Source: Revista Española de Cardiología (English Edition)Author(s): Laura Galian-Gay, Blanca Gordon, Josep Ramón Marsal, Agnès Rafecas, Antonia Pijuan Domènech, Miguel Angel Castro, Maria T. Subirana Domènech, Carlos Sureda, Berta Miranda, Gerard Martí, David García-Dorado, Laura Dos SubiràAbstractIntroduction and objectivesAlthough pulmonary valve stenosis (PVS) is considered a low risk congenital heart disease, there have been reports of complications and the need for reintervention throughout follow-up. The aims ...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 24 May 2019Source: Canadian Journal of CardiologyAuthor(s): Riina M. Kandolin, Christiane C. Wiefels, Cláudio Tinoco Mesquita, Aun-Yeong Chong, Paul Boland, David Glineur, Louise Sun, Rob S. Beanlands, Lisa M. MielniczukAbstractThis review describes the current evidence and controversies for viability imaging to direct revascularization decisions and the impact on patient outcomes. Balancing procedural risks and possible benefit from revascularization is a key question in patients with heart failure of ischemic origin (IHF). Different stages of ischemia induce adaptive changes in m...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
ConclusionsThe UNIVERSE study aims to provide dosing, pharmacokinetics/pharmacodynamics, safety, and efficacy information on the use of rivaroxaban, an oral anticoagulant, versus acetylsalicylic acid, an antiplatelet agent, in children with single ventricle physiology after the Fontan procedure.
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 23 May 2019Source: Journal of Cancer PolicyAuthor(s): Steve Langton, Derek Lowe, Simon N Rogers, Annette Plüddemann, Clare BankheadAbstractBackgroundThe ‘two-week rule’ (TWR) fast-track cancer referral system for head and neck cancers was introduced by the UK government in 2000, to facilitate earlier diagnosis. However, little work has compared stage on diagnosis of cancer before and after the implementation of the system.Objectives•Describe the presentation of oral cancer in Merseyside from 1992-2012.•To evaluate whether stage on presentation has improved after...
Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research
ConclusionsThe investigative team developed a novel breast cancer treatment DA that is acceptable to women ≥70 years with a history of ER+, HER2-, early stage breast cancer. Next, the DA's efficacy needs to be tested with diverse older women newly diagnosed with breast cancer.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 29 April 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Yaohua Cao, Ning Wan, Zhuoru Liang, Jingmei Xie, Sen Wang, Tengfei Lin, Tiantian Zhang, Jie JiangAbstractMany new regimens have been applied to newly diagnosed transplant-ineligible multiple myeloma, but no head-to-head research has been performed to compare the efficacy of these treatments. Currently lenalidomide plus dexamethasone (Rd) is one of the standard treatments. Our aim was to make a comparison of these treatments to Rd by a network meta-analysis. We performed a systematic review and network meta-analysis. We ...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Publication date: August 2019Source: Cancer Epidemiology, Volume 61Author(s): Upma Sharma, Pallavi Singhal, Kapil Bandil, Rajeshwar Patle, Anoop kumar, Kausar Neyaz, Surojit Bose, Ajay Kumar Dewan, Ravi Mehrotra, Veena Sharma, Mausumi BharadwajAbstractBackground: Despite being most preventable malignancies associated with smoked and smokeless tobacco products, squamous cell carcinoma of oral cavity is one of the most common malignancy in India. The aim of the present study was to evaluate the role of TLRs in oral pre-cancerous, cancerous cases and their genotypic correlation with HPV/EBV, co-infection &lifestyle habits...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 23 May 2019Source: Cancer CellAuthor(s): Ruidong Xue, Lu Chen, Chong Zhang, Masashi Fujita, Ruoyan Li, Shu-Mei Yan, Choon Kiat Ong, Xiwen Liao, Qiang Gao, Shota Sasagawa, Yanmeng Li, Jincheng Wang, Hua Guo, Qi-Tao Huang, Qian Zhong, Jing Tan, Lisha Qi, Wenchen Gong, Zhixian Hong, Meng LiSummaryWe performed genomic and transcriptomic sequencing of 133 combined hepatocellular and intrahepatic cholangiocarcinoma (cHCC-ICC) cases, including separate, combined, and mixed subtypes. Integrative comparison of cHCC-ICC with hepatocellular carcinoma and intrahepatic cholangiocarcinoma revealed that...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Publication date: Available online 23 May 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Hyun Yong Koh, Tae Hwan Kim, Youn Ho Sheen, Seung Won Lee, Jaewoo An, Mi Ae Kim, Man Yong Han, Dong Keon Yon
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Go online to PeerView.com/PDD860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, a multidisciplinary panel of interventional radiology, hepatology, and medical oncology experts provide an in-depth analysis of the latest data for approved and emerging systemic treatment options and recent evidence on locoregional and multimodal approaches for patients with HCC. In addition, the expert panel provides guidance on strategies to optimally select and timely transition between locoregional and systemic therapies. Upon completion of this activity, participants s...
Source: PeerView CME/CE Audio Podcast - Immunology - Category: Allergy & Immunology Authors: Tags: Science, Medicine Source Type: podcasts
More News: African Health | Alcoholism | Allergy & Immunology | Asthma | Autoimmune Disease | Biochemistry | Biology | Bone Marrow Aspiration and Biopsy | Brain | Brain Cancers | Brain Tumor | Breast Carcinoma | Canada Health | Cancer | Cancer & Oncology | Carcinoma | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Chemistry | Colon Cancer | Colorectal Cancer | Craniofacial Surgery | Databases & Libraries | Dentistry | Dermatology | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Diets | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Epidemiology | Epithelial Cancer | Gastric (Stomach) Cancer | Gastroenterology | Genetics | Genital Warts | Glioma | Glucosamine | Grants | Head and Neck Cancer | Health Management | Heart | Hematology | Hepatocellular Carcinoma | HNSCC | Hormones | HPV Testing | Human Papillomavirus (HPV) | Insulin | Iodine | Jordan Health | Kidney Transplant | Laboratory Medicine | Learning | Lessons | Lichen Planus | Liver | Liver Cancer | Liver Transplant | Lung Cancer | Lung Transplant | Lupus | Melatonin | Metabolic Syndrome | Middle East Health | Molecular Biology | Neurology | Neuroscience | Neurosurgery | Non-Small Cell Lung Cancer | Nutrition | Obesity | Oral Cancer | Oral Cavity Cancer | Oropharyngeal Cancer | Orthopaedics | Pancreas | Pancreatic Cancer | Pathology | Physiology | Psychiatry | Research | Salivary Gland Cancer | Science | Scleroderma | Skin | Skin Biopsy | Skin Cancer | Sleep Disorders | Sleep Medicine | Smokers | South Africa Health | Squamous Cell Carcinoma | Stem Cell Therapy | Stem Cells | Study | Thrombosis | Thyroid | Thyroid Cancer | Translocation | Universities & Medical Training | Urology & Nephrology | Workshops