Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective

Conclusion
Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; Hema et al., 2017; Lindsay et al., 2017). Exposure to bacteria, virus, toxins, pesticides, stress, life styles changes, sleep disorders, etc, all (in combination or alone) affecting the circadian clock and increase vulnerability to head and neck pathologies (Hooven et al., 2009; LeGates et al., 2014; Cui et al., 2016; Potter et al., 2016; Koch et al., 2017; Kopp et al., 2017). Omics approaches need to be combined with tests and biosensor data for each patient to get most out of them. Recently, there was noted a growing interest on clinical testing of the ability of drugs/small molecules to reset the circadian clock and treat diseases, such as diabetes and cancer (Antoch and Chernov, 2009; He and Chen, 2016; Tamai et al., 2018). Combined omics will be needed to monitor the effects of drugs and individual health outcome. Not least, saliva may become a gold stand...

Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research