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Shock-Waves Reduce Finger Ulcers in Scleroderma
Compared with conventional treatment, extracorporeal shock-wave therapy resulted in a significant decrease in finger ulcers. (Source: CancerNetwork)
Source: CancerNetwork - November 22, 2017 Category: Cancer & Oncology Authors: Gregory M. Weiss, M.D. Tags: Scleroderma Systemic Sclerosis Rheumatic Diseases Source Type: news

Shock-Waves Reduce Finger Ulcers in Scleroderma
Compared with conventional treatment, extracorporeal shock-wave therapy resulted in a significant decrease in finger ulcers. (Source: ConsultantLive)
Source: ConsultantLive - November 22, 2017 Category: Internal Medicine Authors: Gregory M. Weiss, M.D. Tags: Scleroderma Systemic Sclerosis Rheumatic Diseases Source Type: news

SPM in Real Life: Fall β€˜17
NEW MEMBERS: Fall ‘17 Brief bios/plugs for new members (extracted from the Introduce Yourself Connect Community) After returning to school to become an OR surgical tech, Mary Mack’s heart health declined, and she quickly learned to become a strong advocate for herself. Feeling that no one was into her participatory style, Mary believes a radical change in medical student education is necessary to change the culture of medicine. She is passionate about helping to make that change happen. Her other interests include playing the guitar and speaking Mandarin Chinese. Jim Skinner created the Smart Patient Academy a...
Source: Society for Participatory Medicine - November 13, 2017 Category: General Medicine Authors: Nanette Mattox Tags: Newsletter Source Type: news

Pulmonary Progression Can be Rapid in SSc (CME/CE)
(MedPage Today) -- Even in early systemic sclerosis, almost half had PAH (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - October 25, 2017 Category: Primary Care Source Type: news

Intestinal Microbiome in Scleroderma Intestinal Microbiome in Scleroderma
How has our understanding of the involvement of intestinal microbiome in scleroderma recently evolved?Current Opinion in Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 16, 2017 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

A revealing repertoire for systemic sclerosis
(Source: ScienceNOW)
Source: ScienceNOW - October 5, 2017 Category: Science Authors: Fogg, C. N. Tags: twis Source Type: news

Scleroderma
Former school teacher Jay Virdee has been diagnosed with the rare autoimmune disease scleroderma. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - September 23, 2017 Category: Consumer Health News Source Type: news

Dame Margaret Turner-Warwick obituary
Pioneering physician who played a fundamental role in the development of modern respiratory medicineWhen Margaret Turner-Warwick, who has died aged 92, entered the field of respiratory medicine in the 1950s, it was a time of great change. Effective treatment fortuberculosis had recently been introduced, and the adverse effects of cigarette smoking on the lung were beginning to be appreciated.The focus of academic research had been limited to understanding and measuring lung function, but with her colleagues Jack Pepys andDeborah Doniach, Margaret expanded it to include the immunology of the lung, and particularly of the fi...
Source: Guardian Unlimited Science - September 18, 2017 Category: Science Authors: Anthony Newman Taylor Tags: Medical research Science Health Society Health policy Public services policy Politics Source Type: news

Update of EULAR Recommendations for Systemic Sclerosis Update of EULAR Recommendations for Systemic Sclerosis
This article provides updated guidance concerning systemic sclerosis treatment options.Annals of the Rheumatic Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 29, 2017 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

'More than Systemic Sclerosis: The Inside Story' - patients reveal the unseen impact of lung fibrosis
'More than Systemic Sclerosis: The Inside Story' launches today to mark World Scleroderma Day. This global initiative highlights the importance of understanding the 'inside story' of each individual living with systemic sclerosis, and to increase awareness of the potential serious consequences when fibrosis develops in vital organs such as the lungs. (Source: World Pharma News)
Source: World Pharma News - June 29, 2017 Category: Pharmaceuticals Tags: Featured Boehringer Ingelheim Business and Industry Source Type: news

Tired and breathless? YOU could be suffering from a life-threatening auto-immune condition
TIREDNESS and feeling out of breath are two symptoms of advanced scleroderma - a life-threatening auto-immune condition. (Source: Daily Express - Health)
Source: Daily Express - Health - June 28, 2017 Category: Consumer Health News Source Type: news

New tools help early diagnosis of systemic sclerosis
(European League Against Rheumatism) The results of two studies presented today at the Annual European Congress of Rheumatology 2017 press conference highlight the use of two new tools, which can potentially play a pivotal role in the early diagnosis of Systemic Sclerosis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 14, 2017 Category: International Medicine & Public Health Source Type: news

Scleroderma
Title: SclerodermaCategory: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 6/8/2017 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - June 8, 2017 Category: Rheumatology Source Type: news

Disease Awareness Months Work, Even If You Don't Wear The Ribbon
June ​is the month for more than 10 disease-related awareness campaigns, including Myasthenia Gravis Awareness Month, National Congenital Cytomegalovirus Awareness Month and National Scleroderma Awareness Month. It also hosts a handful of awareness weeks and days, ranging from Helen Keller Deaf-Blind Awareness Week to World Sickle Cell Day. June’s awareness list is shorter than most, but every month is full of diseases and disorders to take note of. You probably haven’t heard of half of them, and you’re not alone. So what’s the point of an awareness day, week or month? To understand the chall...
Source: Healthy Living - The Huffington Post - June 2, 2017 Category: Consumer Health News Source Type: news

Study suggests link between imbalanced gut microbiome and systemic sclerosis
This study is the first to examine gastrointestinal bacterial composition in two independent groups of people with systemic sclerosis. Systemic sclerosis, also known as scleroderma, is an autoimmune disease affecting the body ’s connective tissue. It is characterized by a hardening and scarring of skin and can progress to inflammation and scarring in the organs such as kidneys, heart, lungs and gastrointestinal tract. Previous UCLA-led research  detailed a link between the disease and the imbalance in the gut microbiome and suggested that this imbalance contributed to scleroderma’s symptoms.METHODThe ...
Source: UCLA Newsroom: Health Sciences - May 12, 2017 Category: Universities & Medical Training Source Type: news

Imbalanced gut microbiome linked to systemic sclerosis, study suggests
Americans and Norwegians with systemic sclerosis had higher levels of bacteria that can cause inflammation and lower levels of bacteria that are believed to protect against inflammation compared with healthy people. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 12, 2017 Category: Science Source Type: news

Is Health Insurance A Right Or A Privilege?
Now more than ever, health insurance is a staple story in the 24-hour news cycle. Opinions vary widely on the issue, as do politician’s thoughts on the matter. Debates rage, tensions grow, and deeper divides are formed as our government wrestles with this colossal dispute. Nestled at the heart of it all though is a basic question: Is health insurance a right or a privilege in the United States? I’m alive today because my school district, where I’ve now taught for 20 years, offers the ‘Cadillac of insurance plans.’ On April 26, 2006, I checked into the hospital for a scheduled C-section. Due to...
Source: Healthy Living - The Huffington Post - May 8, 2017 Category: Consumer Health News Source Type: news

EULAR Update Targets Organ Involvement in Systemic Sclerosis (CME/CE)
(MedPage Today) -- New recommendations address many -- but not all -- SSc-related organ complications (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - May 5, 2017 Category: Primary Care Source Type: news

Corbus says anti-inflammatory drug will enter late-stage trial this year
Norwood-based Corbus Pharmaceuticals said Wednesday that it plans to launch a Phase 3 trial of its sole drug in development in the fourth quarter of 2017, paving the way for a possible FDA filing in 2019. Corbus (Nasdaq: CRBP), the state’s top-performing public biotech last year, said that it planned to advance its anti-inflammatory drug anabasum into a single, year-long Phase 3 study for the treatment of scleroderma, a rare autoimmune disease. There is currently no approved treatment for the… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - April 5, 2017 Category: Pharmaceuticals Authors: Max Stendahl Source Type: news

Scleroderma Symptoms and Signs
Title: Scleroderma Symptoms and SignsCategory: Doctor's& Expert's views on SymptomsCreated: 7/19/2013 12:00:00 AMLast Editorial Review: 4/4/2017 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - April 4, 2017 Category: Rheumatology Source Type: news

[Perspective] Fibroblasts become fat to reduce scarring
Following cutaneous injury in adult mammals, one of two outcomes can occur: successful healing with scar formation or nonsuccessful healing and a chronic wound. In humans, scar formation can be classified in terms of “normal scar” formation versus pathologically increased fibrosis, as seen in hypertrophic scarring and keloids (1). Although scarring does not look or function like surrounding unwounded skin, it allows one to survive injury (and hence, procreate). However, extensive scarring from burns and conditions such as scleroderma or epidermolysis bulosa are not only unsightly but also contribute to substant...
Source: ScienceNOW - February 16, 2017 Category: Science Authors: Charles K. F. Chan Tags: Tissue Regeneration Source Type: news

Combo Tx Aids in Scleroderma PAH (CME/CE)
(MedPage Today) -- Trial data support ambrisentan plus tadalafil (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - January 6, 2017 Category: Cardiology Source Type: news

January 2017
Pregnancy and Beyond: Make Healthy Choices for Yourself and Your Baby...How to Spot and Prevent Deep Vein Thrombosis: When the Clot Thickens...Palliative Care Improves Quality of Life...Scleroderma Affects Skin and More...Featured Web Site: Types of Cancer (Source: NIH News in Health)
Source: NIH News in Health - January 1, 2017 Category: Consumer Health News Source Type: news

Gene Activity Predicts Progression of Systemic Sclerosis Gene Activity Predicts Progression of Systemic Sclerosis
A 415-gene expression profile distinguished skin from patients with systemic sclerosis from healthy skin and predicted response to treatment a year sooner than did conventional skin-pinch testing.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 23, 2016 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Personal Health: Cold Hands May Signal Raynaud ’ s Phenomenon
The condition, affecting up to 5 percent of the population, is uncomfortable but not necessarily dangerous. (Source: NYT Health)
Source: NYT Health - December 5, 2016 Category: Consumer Health News Authors: JANE E. BRODY Tags: Skin Anxiety and Stress Scleroderma Seasons and Months Source Type: news

Top-performing Mass. biotech Corbus extends study of promising drug
Norwood-based Corbus Pharmaceuticals, the top-performing biotech stock in the state so far in 2016, said Tuesday that it will extend a Phase 2 study of its only drug in development. Corbus (Nasdaq: CRBP) said that the FDA had approved a one-year, open-label extension study of the trial of anti-inflammatory drug Resunab to treat skin-predominant dermatomyositis. In April, the regulator approved a one-year extension study of Resunab for patients with systemic sclerosis. The com pany said in a statement… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - November 29, 2016 Category: Pharmaceuticals Authors: Max Stendahl Source Type: news

Lactose Malabsorption in Systemic Sclerosis Lactose Malabsorption in Systemic Sclerosis
This study investigated the relationship between dietary lactose intake and gastrointestinal dysfunction.Alimentary Pharmacology & Therapeutics (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - November 15, 2016 Category: Allergy & Immunology Tags: Gastroenterology Journal Article Source Type: news

Corbus drug succeeds in mid-stage scleroderma study, shares surge
(Reuters) - Corbus Pharmaceuticals Holdings Inc said its only drug outperformed a placebo in a mid-stage study involving patients with a form of systemic sclerosis, an incurable autoimmune condition caused by abnormal growth of connective tissue. (Source: Reuters: Health)
Source: Reuters: Health - November 14, 2016 Category: Consumer Health News Tags: healthNews Source Type: news

Dermatology: five pictorial cases and outcomes
Five illustrated cases of skin conditions, including pityriasis/tinea amiantacea, morphea (localised scleroderma), nicorandil-induced ulceration and two cases showing the effectiveness of topical chemotherapy agents in skin dysplasia. (Source: GP Online Education)
Source: GP Online Education - November 8, 2016 Category: Primary Care Tags: 15.10 Skin Problems Source Type: news

Risk Factors for PAH Development in Systemic Sclerosis Risk Factors for PAH Development in Systemic Sclerosis
Which factors may contribute to the development of pulmonary arterial hypertension among patients with systemic sclerosis?BMC Pulmonary Medicine (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - November 7, 2016 Category: Surgery Tags: Pulmonary Medicine Journal Article Source Type: news

Rituximab Effective Long-Term for Systemic Sclerosis (CME/CE)
(MedPage Today) -- The B-cell depletion therapy may fill a need for safe agents that stabilize lung function (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - November 5, 2016 Category: Rheumatology Source Type: news

Study identifies method for slowing skin fibrosis in scleroderma
Ryan MaassNEW YORK, Oct. 31 (UPI) -- Researchers at the Hospital for Special Surgery in New York City have uncovered a potential method for slowing skin fibrosis for patients with scleroderma. (Source: Health News - UPI.com)
Source: Health News - UPI.com - October 31, 2016 Category: Consumer Health News Source Type: news

New study suggests way to slow skin fibrosis in scleroderma
A possible mechanism behind the fibrosis that occurs in scleroderma has now been identified, a mechanism, researchers say, that may one day lead to a treatment for the disease. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 31, 2016 Category: Science Source Type: news

New study suggests way to slow skin fibrosis in scleroderma
(Hospital for Special Surgery) New and ongoing research at Hospital for Special Surgery in New York City has identified a possible mechanism behind the fibrosis that occurs in scleroderma -- a mechanism that may one day lead to a treatment for the disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 31, 2016 Category: Global & Universal Source Type: news

Orphan Drug Designation Granted to Nintedanib for Treatment of Systemic Sclerosis, including Associated Interstitial Lung Disease
(Source: Boehringer Ingelheim Press Releases)
Source: Boehringer Ingelheim Press Releases - September 8, 2016 Category: Research Source Type: news

Orphan Drug Designation Granted to Nintedanib for Treatment of Systemic Sclerosis, including Associated Interstitial Lung Disease
(Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - September 7, 2016 Category: Research Source Type: news

Nailfold Capillaroscopy Excludes Scleroderma in Raynaud ’s (CME/CE)
(MedPage Today) -- Test had impressive 90% negative predictive value for SSc (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - August 26, 2016 Category: Dermatology Source Type: news

Should Women Have Breast Implants Removed?
It was a story with a bit of irony, as well as ominous health warnings. Crystal Hefner, the 30-year-old wife of Playboy magazine mogul Hugh Hefner, announced in a story in People magazine last month that she'd had her breast implants removed because they were making her sick. Hefner posted a photo of her post-surgery self on Instagram with the caption, "Using 2016 to reclaim my health and embrace and love myself for the real me." The former model, now a DJ, was diagnosed a few months back with Lyme disease. Her symptoms included intolerance to foods and beverages as well as back, neck, and shoulder pain. Hefn...
Source: Healthy Living - The Huffington Post - August 2, 2016 Category: Consumer Health News Source Type: news

New Phase III study of nintedanib in people with systemic sclerosis and lung fibrosis
(Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - July 25, 2016 Category: Research Source Type: news

Taking it personally, cutting-edge biotech snags $45 million
As Dr. Hal Dietz fielded offers to spin out his research from Johns Hopkins University into a venture-backed biotech company focused on fibrotic diseases, he turned to MPM Capital's Luke Evnin. Evnin, a founder of MPM, is chairman of the Scleroderma Research Foundation, which had funded Dietz's fibrosis research work over the last seven or eight years with $1 million. It is a role that has given Evnin a front-row seat to the work done in academic labs aimed at skin-thickening and connective tissue… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - July 20, 2016 Category: Pharmaceuticals Authors: Ron Leuty Source Type: news

Taking it personally, cutting-edge biotech snags $45 million
As Dr. Hal Dietz fielded offers to spin out his research from Johns Hopkins University into a venture-backed biotech company focused on fibrotic diseases, he turned to MPM Capital's Luke Evnin. Evnin, a founder of MPM, is chairman of the Scleroderma Research Foundation, which had funded Dietz's fibrosis research work over the last seven or eight years with $1 million. It is a role that has given Evnin a front-row seat to the work done in academic labs aimed at skin-thickening and connective tissue… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - July 20, 2016 Category: Biotechnology Authors: Ron Leuty Source Type: news

Scleroderma: Condition sometimes mistaken for arthritis causes skin and organs to HARDEN
A WOMAN who is bravely battling a condition which causes her skin to harden and even affects the internal organs, has spoken out about her struggle. (Source: Daily Express - Health)
Source: Daily Express - Health - July 8, 2016 Category: Consumer Health News Source Type: news

Angiotensin-converting enzyme (ACE) inhibitors
ACE inhibitors treat a variety of conditions, such as high blood pressure, scleroderma and migraines. Find out more about this class of medication. (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - June 28, 2016 Category: Consumer Health News Source Type: news

Actemra may reduce scleroderma skin thickening
The interleukin-6 inhibitor tocilizumab (Actemra) substantially reduced skin thickening in patients with systemic sclerosis in the “proof-of concept” faSScinate trial, the results of which have now been published in the Lancet. The mean change in the primary endpoint of a modified Rodnan skin... (Source: Skin and Allergy News)
Source: Skin and Allergy News - June 27, 2016 Category: Dermatology Source Type: news

Potential non-invasive screening biomarker for SSc-PAH
Serum asymmetric dimethylarginine may be an effective non-invasive screening biomarker for systemic sclerosis-related pulmonary arterial hypertension, study findings indicate. (Source: MedWire News)
Source: MedWire News - June 15, 2016 Category: Consumer Health News Tags: Pulmonary hypertension Source Type: news

Angiotensin II receptor blockers
, sometimes called angiotensin II inhibitors, treat a variety of conditions, such as high blood pressure, heart failure and scleroderma. (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - June 13, 2016 Category: Consumer Health News Source Type: news

Female sex hormone clue to fighting serious immune disease
The results of a study showed for the first time a beneficial effect of estrogens in experimental models of skin fibrosis that are representative of the disease process in systemic sclerosis (SSc). These findings may explain the increased incidence of SSc in women after the menopause, the greater severity of SSc in men, and importantly open up the possibility of developing potential hormone therapies for this difficult-to-treat condition. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 10, 2016 Category: Science Source Type: news

Reduced RV functional reserve may explain poor SSc-PAH outcomes
Patients who develop pulmonary arterial hypertension as a consequence of systemic sclerosis have poorer right ventricular functional reserve than those with idiopathic disease, research published in Circulation shows. (Source: MedWire News)
Source: MedWire News - June 8, 2016 Category: Consumer Health News Tags: Pulmonary hypertension Source Type: news