Skin Fibrosis in SSc Predicts Outcome
(MedPage Today) -- Progressive skin involvement in systemic sclerosis linked with lung deterioration, all-cause death (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 15, 2019 Category: Primary Care Source Type: news

FDA-and-EMA-regulatory-submission-nintedanib-in-SSc-ILD
Boehringer Ingelheim announces FDA and EMA regulatory submission for nintedanib in systemic sclerosis associated ILDSystemic sclerosis (SSc), also known as scleroderma, is a rare chronic connective tissue diseasePulmonary fibrosis, or fibrosing interstitial lung disease (ILD), is a key driver of mortality in people living with SSc and constitutes a high unmet need1,2Improving the lives of people living with pulmonary fibrosis is a key focus for Boehringer Ingelheim (Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - March 15, 2019 Category: Research Source Type: news

For Juvenile Scleroderma, Look Beyond the Skin
(MedPage Today) -- Patients can also have joint or CNS disease (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - March 13, 2019 Category: Dermatology Source Type: news

Scleroderma activist Farah Khaleck: 'I used to be scared looking in the mirror'
Farah Khaleck has a rare and incurable condition which causes the hardening and tightening of her skin. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - March 3, 2019 Category: Consumer Health News Source Type: news

Economic burden of systemic sclerosis substantial in the US
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - March 1, 2019 Category: Drugs & Pharmacology Source Type: news

Scleroderma Patients Report Poorer Quality of Life (CME/CE)
(MedPage Today) -- Korean study shows significantly worse health-related QoL versus other rheumatic diseases (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - February 26, 2019 Category: Primary Care Source Type: news

Inhibiting cancer-causing protein could prevent scleroderma fibrosis
(Michigan Medicine - University of Michigan) Examining the autoimmune disease at the molecular level led researchers to a specific molecule that could be contributing to the disease progression in patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 26, 2019 Category: Cancer & Oncology Source Type: news

Epigenetic Modulation as a Therapy in Systemic Sclerosis Epigenetic Modulation as a Therapy in Systemic Sclerosis
Could epigenetic regulators represent a potential new therapeutic target in systemic sclerosis?Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 25, 2019 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Quality of Life Poor in Scleroderma
(MedPage Today) -- Worse than in rheumatoid arthritis or lupus (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - February 20, 2019 Category: Primary Care Source Type: news

Nurse has tummy fat injected into her face using 'bum lift' technique to combat agonising disease
Amy Daniels, 51, of Wisconsin, suffers with scleroderma, which causes scarring and poor circulation. The mother’s fat was enriched with her own stem cells before being reinjected. (Source: the Mail online | Health)
Source: the Mail online | Health - February 15, 2019 Category: Consumer Health News Source Type: news

Nurse has procedure similar to the Brazilian bum lift to transfer fat from her stomach to her FACE
Amy Daniels, from Wisconsin, suffers with scleroderma, which leaves scarring and poor circulation. The mothers fat was enriched with her own stem cells before being reinjected. (Source: the Mail online | Health)
Source: the Mail online | Health - February 15, 2019 Category: Consumer Health News Source Type: news

The Experience of Raynaud's Phenomenon in Systemic Sclerosis The Experience of Raynaud's Phenomenon in Systemic Sclerosis
A new review explores the patient impact and disease burden of Raynaud's phenomenon in systemic sclerosis.Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 4, 2019 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Connective tissue on the wrong road -- When organs start to scar
(University of Erlangen-Nuremberg) The increased deposition of connective tissue is a problem in chronic diseases of many organs such as the lungs (idiopathic pulmonary fibrosis), liver (cirrhosis), kidneys (kidney fibrosis), gut (graft versus host disease), and the skin (systemic sclerosis). Up to 40 percent of all deaths in industrial nations are caused by the deposition of connective tissue with subsequent tissue scarring. In spite of this, there are currently very few effective treatments available. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 31, 2019 Category: International Medicine & Public Health Source Type: news

Early Signs for Scleroderma Renal Crisis
(MedPage Today) -- New study lays out range of factors that can increase patients'risk (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - January 19, 2019 Category: Primary Care Source Type: news

Angiotensin II receptor blockers
, sometimes called angiotensin II inhibitors, treat a variety of conditions, such as high blood pressure, heart failure and scleroderma. (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - January 9, 2019 Category: Consumer Health News Source Type: news

CV Risks Similar in SSc and RA, but SSc More Negatively Impacts QoL (CME/CE)
(MedPage Today) -- Multicenter, matched cohort study compares prevalence of comorbidities in systemic sclerosis vs rheumatoid arthritis (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - December 10, 2018 Category: Primary Care Source Type: news

CV Risks High in Systemic Sclerosis
(MedPage Today) -- Similar event rate as for rheumatoid arthritis, despite fewer conventional risk factors (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - December 5, 2018 Category: Cardiology Source Type: news

What Causes Post-Inflammatory Hypopigmentation?
Discussion Hypopigmentation can be worrisome for many families because of cosmesis and the worry that “something is wrong.” The normal natural changes in skin-tone over the year due to different light exposure and wide variations within individuals is not something that many people are aware of. Post-inflammatory hypopigmentation is a common cause of hypopigmentation. Vitiligo is the most common cause of depigmentation. Vitiligo is an acquired, depigmenting disorder with typical lesions appearing as milky white macules with distinct margins that are not scaly. Hair (including eyebrows and eyelashes) can be dep...
Source: PediatricEducation.org - November 12, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Gastrointestinal Involvement in Systemic Sclerosis Gastrointestinal Involvement in Systemic Sclerosis
How are gastrointestinal complications related to systemic sclerosis best diagnosed and managed?Current Opinion in Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 6, 2018 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Clinical study shows effectiveness of a Chinese decoction in alleviating sclerosis
(Natural News) Research has found that a Chinese decoction called Taohong Siwu can be used to treat symptoms of sclerosis. The study, published in the Chinese Journal of Integrative Medicine, assessed the efficacy and safety of bathing therapy with Taohong Siwu decoction in the treatment of diffuse cutaneous systemic sclerosis. Researchers from Gansu Provincial Hospital in Lanzhou,... (Source: NaturalNews.com)
Source: NaturalNews.com - October 30, 2018 Category: Consumer Health News Source Type: news

FDA committed to studying breast implant safety
By Dr. Binita Ashar, director of the division of surgical devices in the FDA’s Center for Devices and Radiological Health Choosing to obtain a breast implant, whether for augmentation or reconstruction, is a deeply personal choice, from the initial decision to undergo breast implant surgery to the size, material and surface texture. These types of decisions should be discussed between a patient and their provider in a transparent and balanced way with clear information about the benefits and risks of the breast implants and the procedure. As a public health agency, we play an important role in ensuring that patients ...
Source: Mass Device - October 29, 2018 Category: Medical Devices Authors: Danielle Kirsh Tags: Blog FDA Voice Source Type: news

Encourage Your Scleroderma Patients to Get Influenza Vaccine Encourage Your Scleroderma Patients to Get Influenza Vaccine
An important new study suggests that the adjuvant-free pandemic influenza A vaccine is safe and effective in patients with scleroderma.Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 29, 2018 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

ACR: Success with Stem Cells in Severe Scleroderma
(MedPage Today) -- Patients remained off DMARDs for more than a decade (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - October 23, 2018 Category: Rheumatology Source Type: news

Stem Cell Transplantation May Aid Hard-to-Treat Scleroderma Patients
Results from a new study led by researchers at Geisel and presented this week at the American College of Rheumatology Annual Scientific Meeting in Chicago, showed that stem cell transplantation was beneficial to scleroderma patients who don’t respond to current immunosuppressive therapies. (Source: News at Dartmouth Medical School)
Source: News at Dartmouth Medical School - October 22, 2018 Category: Hospital Management Authors: Timothy Dean Tags: News Research autoimmune disease Michael Whitfield Scleroderma Source Type: news

Assessing Systemic Lupus Erythematous-Scleroderma Combo
(MedPage Today) -- What are outcomes for patients with both conditions? (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - October 20, 2018 Category: Primary Care Source Type: news

Fast, effective treatment for autoimmune rheumatic diseases
Autoimmune rheumatic diseases like rheumatoid arthritis, lupus and scleroderma are debilitating and occasionally life-threatening. An EU and industry-funded project aims to improve treatment by getting the right therapies to the right patients, fast. (Source: EUROPA - Research Information Centre)
Source: EUROPA - Research Information Centre - October 12, 2018 Category: Research Source Type: news

Breast Implant Study Should Be Taken with a Grain of Salt, FDA Says
A study linking silicone gel-filled breast implants with several rare diseases should be viewed with caution, according to FDA. The authors of the study, published last week in the Annals of Surgery, say they looked at data from nearly 100,000 breast implant procedures gleaned from FDA-mandated postmarket studies for implants made by Johnson & Johnson's Mentor business, and by Allergan. The analysis showed that silicone implants are associated with higher rates of  Sjögren syndrome, scleroderma, rheumatoid arthritis, stillbirth, and melanoma. The researchers reported that 56% of the...
Source: MDDI - September 18, 2018 Category: Medical Devices Authors: Amanda Pedersen Tags: Implants Source Type: news

FDA pushes back on silicone breast implant study
The FDA last week pushed back at a large study showing an association between silicone breast implants and some rare diseases, standing by its record of warning the public about their risks – despite granting approvals to a slew of the implants in recent years. The study, published Sept. 14 in the Annals of Surgery, looked at data from nearly 100,000 breast implant procedures the researchers gleaned from FDA-mandated post-approval studies for implants made by Johnson & Johnson (NYSE:JNJ) unit Mentor and by Allergan (NYSE: AGN). The analysis showed that silicone implants are associated with higher rates of Sj...
Source: Mass Device - September 17, 2018 Category: Medical Devices Authors: Brad Perriello Tags: Featured Food & Drug Administration (FDA) Women's Health Allergan johnsonandjohnson Source Type: news

Early Stage Scleroderma: any experience with implants?
I have a patient that has early stage of Scleroderma and doesn't take medications for it yet. Does anyone have experience with Scleroderma and implants?The postEarly Stage Scleroderma: any experience with implants? appeared first onOsseoNews Dental Implants. (Source: Dental Implants Discussed by Experts)
Source: Dental Implants Discussed by Experts - September 11, 2018 Category: Dentistry Authors: osseonews Tags: Clinical Questions Surgical Source Type: news

Infection Most Common Cause of SSc Admissions
(MedPage Today) -- Inpatient mortality rate 5% in systemic sclerosis (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - September 1, 2018 Category: Primary Care Source Type: news

Regulatory and effector B cells control scleroderma
(Kanazawa University) A Japan-based research team led by Kanazawa University have found reciprocal regulation of B cells on bleomycin-induced scleroderma model. Their research shed light on the roles of cytokine producing B cells in autoimmune diseases. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 30, 2018 Category: Biology Source Type: news

ILD in Scleroderma: Response Markers Remain Elusive
(MedPage Today) -- Proxies for active inflammation failed to predict cyclophosphamide effectiveness (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - July 11, 2018 Category: Primary Care Source Type: news

Systemic Sclerosis: More Common than Expected
(MedPage Today) -- New study puts prevalence four times higher than previous estimate (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - July 5, 2018 Category: Primary Care Source Type: news

Silica and SSc: A Link Confirmed (CME/CE)
(MedPage Today) -- Occupational exposure led to scleroderma in Italian workers (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - July 3, 2018 Category: Primary Care Source Type: news

Rheumatoid Arthritis: A systematic approach
(Bentham Science Publishers) The text combines comprehensive and systematic information about the diseases with a collection of diagnostic images. The key feature of the book is the systemic approach towards medical diagnosis in cases based on radiographic imaging. Topics covered in the book include also include osteoarthritis, lupus, myositis, vasculitis, juvenile arthritis, gout, systemic sclerosis, adult onset Still's disease, Beh ç et's disease and so on. Chapters have been contributed by experts in rheumatology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 25, 2018 Category: International Medicine & Public Health Source Type: news

Queens woman Shirley Alvarez 'trapped' within a doll
Shirley Alvarez, from Queens, New York, was diagnosed aged nine with systemic scleroderma - which can affect the entire body, including blood vessels. (Source: the Mail online | Health)
Source: the Mail online | Health - June 15, 2018 Category: Consumer Health News Source Type: news

New treatment lenebasum shows promise for diffuse cutaneous systemic sclerosis (dcSSc)
(European League Against Rheumatism) The results of an open label extension of a phase II study presented today at the Annual European Congress of Rheumatology (EULAR 2018) demonstrate that lenabasum continues to have acceptable safety and tolerability in diffuse cutaneous systemic sclerosis (dcSSc) with no severe or serious adverse events (AE). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 15, 2018 Category: International Medicine & Public Health Source Type: news

Lenabasum Showing Promise in Systemic Scleroderma Lenabasum Showing Promise in Systemic Scleroderma
The oral, synthetic, nonimmunosuppressive small molecule improves outcome scores for patients with few treatment options, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 14, 2018 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Scleroderma Elbow Tip Pains
Title: Scleroderma Elbow Tip PainsCategory: Doctor's& Expert's views on SymptomsCreated: 4/24/2000 12:00:00 AMLast Editorial Review: 6/13/2018 2:55:09 PM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - June 13, 2018 Category: Rheumatology Source Type: news

Scleroderma - 2001 National Meeting Reports
Title: Scleroderma - 2001 National Meeting ReportsCategory: Doctor's& Expert's views on SymptomsCreated: 11/24/2001 2:59:00 PMLast Editorial Review: 6/13/2018 2:55:09 PM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - June 13, 2018 Category: Rheumatology Source Type: news

Antibodies Help Profile Outcomes in SSc (CME/CE)
(MedPage Today) -- Systemic sclerosis can be classified according to extent of skin involvement and autoantibody profiles (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - May 3, 2018 Category: Rheumatology Source Type: news

Scleroderma and Cancer: A Mechanistic Link? (CME/CE)
(MedPage Today) -- Autoantibody subsets and disease phenotype may determine risk (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - April 26, 2018 Category: Primary Care Source Type: news

Study shows potential of imaging methods for systemic sclerosis-related Raynaud's phenomenon
Current methods of measuring changes in blood flow or skin temperature in the hands of people with systemic sclerosis are subjective and not always sensitive to change. Testing and developing new means of treating systemic sclerosis-related Raynaud's phenomenon in future clinical trials could now be made easier thanks to two imaging methods that have been validated by new research. Arthritis Research UK has funded a study led by the University of Manchester showing how laser speckle contrast imaging (LSCI), which measures blood flow, and thermography techniques, which measure skin temperature, could both play an i...
Source: Arthritis Research UK - March 22, 2018 Category: Rheumatology Source Type: news

FDA grants Fast Track designation to nintedanib for the treatment of systemic sclerosis with associated interstitial lung disease
Boehringer Ingelheim announced today that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation to nintedanib for the treatment of systemic sclerosis with associated interstitial lung disease (SSc-ILD). The FDA's Fast Track designation facilitates the development of new therapies that treat serious conditions and fulfill an unmet medical need in an effort to get treatments to those in need sooner. (Source: World Pharma News)
Source: World Pharma News - March 19, 2018 Category: Pharmaceuticals Tags: Featured Boehringer Ingelheim Business and Industry Source Type: news

UTHealth's Shervin Assassi awarded $1.4 million to personalize scleroderma treatments
(University of Texas Health Science Center at Houston) At The University of Texas Health Science Center at Houston (UTHealth), rheumatologist Shervin Assassi, M.D., is developing a blood test to determine which drugs work best for scleroderma patients with lung disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 8, 2018 Category: International Medicine & Public Health Source Type: news

Inspirational patient stories reveal the challenging realities of living with devastating rare disease
Boehringer Ingelheim unveils a new phase of "More Than Scleroderma: The Inside Story", and launches the new patient website www.morethanscleroderma.com. The global initiative highlights the importance of understanding the 'inside story' of each individual living with scleroderma, also known as systemic sclerosis. (Source: World Pharma News)
Source: World Pharma News - February 27, 2018 Category: Pharmaceuticals Tags: Featured Boehringer Ingelheim Business and Industry Source Type: news

Systemic Sclerosis World Congress
(Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - February 14, 2018 Category: Research Source Type: news

Chesco gene therapy company seeks FDA OK to begin human testing of skin disorder treatment
The treatment is for a rare condition called localized scleroderma. (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - February 7, 2018 Category: Health Management Authors: John George Source Type: news

Synthetic DMARDs May Blunt Pneumococcal Vaccine Response in Systemic Sclerosis Synthetic DMARDs May Blunt Pneumococcal Vaccine Response in Systemic Sclerosis
Pneumococcal vaccination yields a satisfactory antibody response in patients with systemic sclerosis (SSc), but synthetic disease-modifying antirheumatic drugs (DMARDs) might reduce the vaccine response in these individuals, according to a report from Sweden.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 24, 2018 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Stem cell transplant helps people with severe scleroderma
A study of people with severe scleroderma found that a new approach using stem cell transplants provides a better outcome than an immune-suppressing drug. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - January 23, 2018 Category: Consumer Health News Source Type: news