High-Res CT Has Key Role Detecting Lung Disease in Systemic Sclerosis High-Res CT Has Key Role Detecting Lung Disease in Systemic Sclerosis
The first evidence-based consensus statements for systemic sclerosis-associated interstitial lung disease (SSc-ILD) recommend use of high-resolution computed tomography (CT) for screening and diagnosis, and offer guidance on when to initiate or escalate emerging treatment options.Reuters Health Information (Source: Medscape Radiology Headlines)
Source: Medscape Radiology Headlines - February 4, 2020 Category: Radiology Tags: Rheumatology News Source Type: news

Hyaluronic Acid and Platelet-Rich Plasma for Scleroderma Hyaluronic Acid and Platelet-Rich Plasma for Scleroderma
Scleroderma patients treated with filler injections of hyaluronic acid and platelet-rich plasma realized improvements in skin atrophy and quality of life.Arthritis Research & Therapy (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - January 28, 2020 Category: Pathology Tags: Rheumatology Journal Article Source Type: news

Garmin's Kao donates $20M to create institute within hospital
Garmin Ltd. co-founder and Executive Chairman Min Kao has donated $20 million to a nonprofit Los Angeles hospital. The gift from the Kao Family Foundation will create the Kao Autoimmunity Institute to advance research and treatment of rheumatologic diseases at Cedars-Sinai Medical Center, according to a Tuesday release. The donation also will establish a program within the institute that provides training and education for people with scleroderma, a disease that causes chronic hardening and tightening… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - December 12, 2019 Category: Biotechnology Authors: Lily Lieberman Source Type: news

Researchers create accurate model of organ scarring using stem cells in a lab
Every organ in the body is capable, to some extent, of repairing itself after an injury. As part of this process, scar tissue forms and then recedes to make room for normal tissue when healing is complete.However, when healing is disrupted — whether by chronic injury or disease — the cells that make up scar tissue can go rogue, continuously dividing and spreading until the scar eventually strangles the organ it was intended to help heal, which can lead to organ failure.That progressive, out-of-control scarring is called fibrosis, and it can occur in any organ in the body. Fibrosis plays a major role in many dis...
Source: UCLA Newsroom: Health Sciences - December 11, 2019 Category: Universities & Medical Training Source Type: news

Systemic Sclerosis Highlights From 2019 ACR Annual Meeting Systemic Sclerosis Highlights From 2019 ACR Annual Meeting
Dr Robert Spiera of the Hospital for Special Surgery in New York City reviews key studies related to systemic sclerosis, presented at the 2019 American College of Rheumatology annual meeting.Medscape (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 6, 2019 Category: Consumer Health News Tags: Rheumatology ReCAP Source Type: news

FDA Approves First Treatment for ILD With Systemic Sclerosis, Scleroderma
Title: FDA Approves First Treatment for ILD With Systemic Sclerosis, SclerodermaCategory: Health NewsCreated: 9/10/2019 12:00:00 AMLast Editorial Review: 9/10/2019 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - September 10, 2019 Category: Rheumatology Source Type: news

FDA Approves First Treatment, Ofev (Nintedanib), for ILD With Systemic Sclerosis, Scleroderma
MONDAY, Sept. 9, 2019 -- The U.S. Food and Drug Administration granted the first approval for a drug to slow the decline of pulmonary function in interstitial lung disease associated with systemic sclerosis or scleroderma (SSc-ILD), the agency... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 9, 2019 Category: General Medicine Source Type: news

FDA OKs Nintedanib (Ofev) for Rare Lung Disease FDA OKs Nintedanib (Ofev) for Rare Lung Disease
Nintedanib capsules are approved for slowing the rate of decline in pulmonary function in adults with systemic sclerosis-associated interstitial lung disease.News Alerts (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - September 9, 2019 Category: Allergy & Immunology Tags: Pulmonary Medicine News Source Type: news

FDA approves first treatment for patients with rare type of lung disease
The U.S. Food and Drug Administration has approved Ofev (nintedanib) capsules to slow the rate of decline in pulmonary function in adults with interstitial lung disease associated with systemic sclerosis or scleroderma, called SSc-ILD. It is the first FDA-approved treatment for this rare lung condition. (Source: World Pharma News)
Source: World Pharma News - September 9, 2019 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

FDA Approves Ofev (nintedanib) for Interstitial Lung Disease Associated with Systemic Sclerosis or Scleroderma (SSc-ILD)
September 06, 2019 -- The U.S. Food and Drug Administration today approved Ofev (nintedanib) capsules to slow the rate of decline in pulmonary function in adults with interstitial lung disease associated with systemic sclerosis or scleroderma,... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - September 6, 2019 Category: Drugs & Pharmacology Source Type: news

FDA Panel Recommends Nintedanib for Rare Lung Disease FDA Panel Recommends Nintedanib for Rare Lung Disease
Small effect size for primary endpoint in systemic sclerosis-associated interstitial lung disease study, and lack of significant difference between groups for secondary outcomes, were sticking points.Medscape Medical News (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - July 26, 2019 Category: Rheumatology Tags: Rheumatology News Source Type: news

Higher oestrogen levels linked to scleroderma severity
Older men with severe scleroderma have higher oestrogen levels than postmenopausal women with scleroderma, according to research published inArthritis Research& Therapy.Science Daily  (Source: Society for Endocrinology)
Source: Society for Endocrinology - June 10, 2019 Category: Endocrinology Source Type: news

Higher estrogen levels linked to more severe disease in scleroderma
(Medical University of South Carolina) Scleroderma is a connective tissue disease that hardens the skin and scars the organs. Older men with scleroderma had higher estrogen levels than healthy older men or postmenopausal women with scleroderma, report Medical University of South Carolina and University of Pittsburgh researchers in Arthritis Research& Therapy. Higher estradiol levels were associated with more severe disease and heart involvement in these men and, in those positive for the autoantibody Scl-70, a greater risk of death. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - June 5, 2019 Category: International Medicine & Public Health Source Type: news

Using New Autoantibodies in Rheumatic Disease: An Update Using New Autoantibodies in Rheumatic Disease: An Update
Dr Kevin Deane explains how recent advances are shining a light on the potential role that newer autoantibodies may play in the clinical care of RA, myositis, and scleroderma.Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 23, 2019 Category: Consumer Health News Tags: Rheumatology Viewpoint Source Type: news

nintedanib slows pulmonary function loss in people with ssc-ild
Phase III study showed nintedanib slows the loss of pulmonary function in people living with systemic sclerosis associated ILD1Results of pivotal Phase III SENSCIS ®trial published today in the New England Journal of Medicine (NEJM) and presented at the American Thoracic Society Conference in Dallas, USAInterstitial lung disease (ILD) is a key driver of mortality in people living with systemic sclerosis (SSc) – also known as scleroderma – and the absence of approved treatment options constitutes a high unmet need2,3FDA grants priority review to application for regulatory approval for nintedanib in patients ...
Source: Boehringer Ingelheim Corporate News - May 20, 2019 Category: Research Source Type: news

Exploring new treatments for autoimmune diseases
(Michigan Medicine - University of Michigan) A new grant will allow Michigan Medicine researchers to explore personalized approaches to treating autoimmune diseases such as scleroderma, lupus, rheumatoid arthritis and others. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 6, 2019 Category: International Medicine & Public Health Source Type: news

Hyaluronic Acid Contraindicated in Scleroderma Skin Ulcers Hyaluronic Acid Contraindicated in Scleroderma Skin Ulcers
While evidence shows hyaluronic acid-based products are effective for healing chronic skin wounds, they may produce significant negative effects in patients with scleroderma.Wounds (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 29, 2019 Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news

Anti-Neutrophil Cytoplasmic Antibodies in Systemic Sclerosis Anti-Neutrophil Cytoplasmic Antibodies in Systemic Sclerosis
A new study examines the clinical associations of anti-neutrophil cytoplasmic antibodies in systemic sclerosis. What have we learned?Arthritis Research & Therapy (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - April 17, 2019 Category: Intensive Care Tags: Rheumatology Journal Article Source Type: news

France Bans Textured Breast Implants
France has banned several types of textured breast implants that have been linked to a rare form of cancer, and more countries appear to be following suit, including Canada and the Netherlands. For years researchers have raised concern about the potential association between breast implants and anaplastic large cell lymphoma (ALCL), a very rare form of cancer, but France is the first country to ban the devices. The ban took effect on Friday and covers macro-textured implants and implants with a polyurethane coating. The National Agency for Safety of Medicines and Health Products (ANSM) in France notified manufa...
Source: MDDI - April 8, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: Implants Regulatory and Compliance Source Type: news

Boehringer Ingelheim announces FDA and EMA regulatory submission for nintedanib in systemic sclerosis associated ILD
Boehringer Ingelheim has filed for regulatory approval of nintedanib in patients with systemic sclerosis associated interstitial lung disease (SSc-ILD) with the FDA and EMA. Nintedanib as an anti-fibrotic medicine is already approved in more than 70 countries for the treatment of patients living with idiopathic pulmonary fibrosis (IPF). (Source: World Pharma News)
Source: World Pharma News - March 26, 2019 Category: Pharmaceuticals Tags: Featured Boehringer Ingelheim Business and Industry Source Type: news

Biomarker for dcSSc Outcome ID'd (CME/CE)
(MedPage Today) -- Progressive skin fibrosis associated with lung deterioration, all-cause death in patients with diffuse cutaneous systemic sclerosis (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 22, 2019 Category: Primary Care Source Type: news

FDA Busts J & amp;J and Sientra Over Breast Implant Compliance
FDA busted two manufacturers of silicone gel-filled breast implants this week for failure to comply with post-approval study requirements. The agency sent warning letters to Irvine, CA-based Mentor Worldwide, a unit of Johnson & Johnson, and to Santa Barbara, CA-based Sientra for deficiencies in each company's post-approval study for silicone breast implant approvals. Breast implants have been a source of contention between patient advocacy groups, industry, and FDA for decades. Implants were banned from the U.S. market from 1992 to 2006, and the devices have been the cause of an ove...
Source: MDDI - March 20, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: Regulatory and Compliance Source Type: news

Boehringer Ingelheim announces FDA and EMA regulatory submission for nintedanib in systemic sclerosis associated ILD
Systemic sclerosis (SSc), also known as scleroderma, is a rare chronic connective tissue disease Pulmonary fibrosis, or fibrosing interstitial lung disease (ILD), is a key driver of mortality in people living with SSc and constitutes a high unmet need ... Biopharmaceuticals, FDA, Regulatory Boehringer Ingelheim, nintedanib, interstitial lung disease (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - March 18, 2019 Category: Pharmaceuticals Source Type: news

Skin Fibrosis in SSc Predicts Outcome
(MedPage Today) -- Progressive skin involvement in systemic sclerosis linked with lung deterioration, all-cause death (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - March 15, 2019 Category: Primary Care Source Type: news

FDA-and-EMA-regulatory-submission-nintedanib-in-SSc-ILD
Boehringer Ingelheim announces FDA and EMA regulatory submission for nintedanib in systemic sclerosis associated ILDSystemic sclerosis (SSc), also known as scleroderma, is a rare chronic connective tissue diseasePulmonary fibrosis, or fibrosing interstitial lung disease (ILD), is a key driver of mortality in people living with SSc and constitutes a high unmet need1,2Improving the lives of people living with pulmonary fibrosis is a key focus for Boehringer Ingelheim (Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - March 15, 2019 Category: Research Source Type: news

For Juvenile Scleroderma, Look Beyond the Skin
(MedPage Today) -- Patients can also have joint or CNS disease (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - March 13, 2019 Category: Dermatology Source Type: news

Scleroderma activist Farah Khaleck: 'I used to be scared looking in the mirror'
Farah Khaleck has a rare and incurable condition which causes the hardening and tightening of her skin. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - March 3, 2019 Category: Consumer Health News Source Type: news

Economic burden of systemic sclerosis substantial in the US
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - March 1, 2019 Category: Drugs & Pharmacology Source Type: news

Scleroderma Patients Report Poorer Quality of Life (CME/CE)
(MedPage Today) -- Korean study shows significantly worse health-related QoL versus other rheumatic diseases (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - February 26, 2019 Category: Primary Care Source Type: news

Inhibiting cancer-causing protein could prevent scleroderma fibrosis
(Michigan Medicine - University of Michigan) Examining the autoimmune disease at the molecular level led researchers to a specific molecule that could be contributing to the disease progression in patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 26, 2019 Category: Cancer & Oncology Source Type: news

Epigenetic Modulation as a Therapy in Systemic Sclerosis Epigenetic Modulation as a Therapy in Systemic Sclerosis
Could epigenetic regulators represent a potential new therapeutic target in systemic sclerosis?Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 25, 2019 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Quality of Life Poor in Scleroderma
(MedPage Today) -- Worse than in rheumatoid arthritis or lupus (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - February 20, 2019 Category: Primary Care Source Type: news

Nurse has tummy fat injected into her face using 'bum lift' technique to combat agonising disease
Amy Daniels, 51, of Wisconsin, suffers with scleroderma, which causes scarring and poor circulation. The mother’s fat was enriched with her own stem cells before being reinjected. (Source: the Mail online | Health)
Source: the Mail online | Health - February 15, 2019 Category: Consumer Health News Source Type: news

Nurse has procedure similar to the Brazilian bum lift to transfer fat from her stomach to her FACE
Amy Daniels, from Wisconsin, suffers with scleroderma, which leaves scarring and poor circulation. The mothers fat was enriched with her own stem cells before being reinjected. (Source: the Mail online | Health)
Source: the Mail online | Health - February 15, 2019 Category: Consumer Health News Source Type: news

The Experience of Raynaud's Phenomenon in Systemic Sclerosis The Experience of Raynaud's Phenomenon in Systemic Sclerosis
A new review explores the patient impact and disease burden of Raynaud's phenomenon in systemic sclerosis.Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 4, 2019 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Connective tissue on the wrong road -- When organs start to scar
(University of Erlangen-Nuremberg) The increased deposition of connective tissue is a problem in chronic diseases of many organs such as the lungs (idiopathic pulmonary fibrosis), liver (cirrhosis), kidneys (kidney fibrosis), gut (graft versus host disease), and the skin (systemic sclerosis). Up to 40 percent of all deaths in industrial nations are caused by the deposition of connective tissue with subsequent tissue scarring. In spite of this, there are currently very few effective treatments available. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 31, 2019 Category: International Medicine & Public Health Source Type: news

Early Signs for Scleroderma Renal Crisis
(MedPage Today) -- New study lays out range of factors that can increase patients'risk (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - January 19, 2019 Category: Primary Care Source Type: news

Angiotensin II receptor blockers
, sometimes called angiotensin II inhibitors, treat a variety of conditions, such as high blood pressure, heart failure and scleroderma. (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - January 9, 2019 Category: Consumer Health News Source Type: news

CV Risks Similar in SSc and RA, but SSc More Negatively Impacts QoL (CME/CE)
(MedPage Today) -- Multicenter, matched cohort study compares prevalence of comorbidities in systemic sclerosis vs rheumatoid arthritis (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - December 10, 2018 Category: Primary Care Source Type: news

CV Risks High in Systemic Sclerosis
(MedPage Today) -- Similar event rate as for rheumatoid arthritis, despite fewer conventional risk factors (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - December 5, 2018 Category: Cardiology Source Type: news

What Causes Post-Inflammatory Hypopigmentation?
Discussion Hypopigmentation can be worrisome for many families because of cosmesis and the worry that “something is wrong.” The normal natural changes in skin-tone over the year due to different light exposure and wide variations within individuals is not something that many people are aware of. Post-inflammatory hypopigmentation is a common cause of hypopigmentation. Vitiligo is the most common cause of depigmentation. Vitiligo is an acquired, depigmenting disorder with typical lesions appearing as milky white macules with distinct margins that are not scaly. Hair (including eyebrows and eyelashes) can be dep...
Source: PediatricEducation.org - November 12, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Gastrointestinal Involvement in Systemic Sclerosis Gastrointestinal Involvement in Systemic Sclerosis
How are gastrointestinal complications related to systemic sclerosis best diagnosed and managed?Current Opinion in Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 6, 2018 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Clinical study shows effectiveness of a Chinese decoction in alleviating sclerosis
(Natural News) Research has found that a Chinese decoction called Taohong Siwu can be used to treat symptoms of sclerosis. The study, published in the Chinese Journal of Integrative Medicine, assessed the efficacy and safety of bathing therapy with Taohong Siwu decoction in the treatment of diffuse cutaneous systemic sclerosis. Researchers from Gansu Provincial Hospital in Lanzhou,... (Source: NaturalNews.com)
Source: NaturalNews.com - October 30, 2018 Category: Consumer Health News Source Type: news

FDA committed to studying breast implant safety
By Dr. Binita Ashar, director of the division of surgical devices in the FDA’s Center for Devices and Radiological Health Choosing to obtain a breast implant, whether for augmentation or reconstruction, is a deeply personal choice, from the initial decision to undergo breast implant surgery to the size, material and surface texture. These types of decisions should be discussed between a patient and their provider in a transparent and balanced way with clear information about the benefits and risks of the breast implants and the procedure. As a public health agency, we play an important role in ensuring that patients ...
Source: Mass Device - October 29, 2018 Category: Medical Devices Authors: Danielle Kirsh Tags: Blog FDA Voice Source Type: news

Encourage Your Scleroderma Patients to Get Influenza Vaccine Encourage Your Scleroderma Patients to Get Influenza Vaccine
An important new study suggests that the adjuvant-free pandemic influenza A vaccine is safe and effective in patients with scleroderma.Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 29, 2018 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

ACR: Success with Stem Cells in Severe Scleroderma
(MedPage Today) -- Patients remained off DMARDs for more than a decade (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - October 23, 2018 Category: Rheumatology Source Type: news

Stem Cell Transplantation May Aid Hard-to-Treat Scleroderma Patients
Results from a new study led by researchers at Geisel and presented this week at the American College of Rheumatology Annual Scientific Meeting in Chicago, showed that stem cell transplantation was beneficial to scleroderma patients who don’t respond to current immunosuppressive therapies. (Source: News at Dartmouth Medical School)
Source: News at Dartmouth Medical School - October 22, 2018 Category: Hospital Management Authors: Timothy Dean Tags: News Research autoimmune disease Michael Whitfield Scleroderma Source Type: news

Assessing Systemic Lupus Erythematous-Scleroderma Combo
(MedPage Today) -- What are outcomes for patients with both conditions? (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - October 20, 2018 Category: Primary Care Source Type: news

Fast, effective treatment for autoimmune rheumatic diseases
Autoimmune rheumatic diseases like rheumatoid arthritis, lupus and scleroderma are debilitating and occasionally life-threatening. An EU and industry-funded project aims to improve treatment by getting the right therapies to the right patients, fast. (Source: EUROPA - Research Information Centre)
Source: EUROPA - Research Information Centre - October 12, 2018 Category: Research Source Type: news

Breast Implant Study Should Be Taken with a Grain of Salt, FDA Says
A study linking silicone gel-filled breast implants with several rare diseases should be viewed with caution, according to FDA. The authors of the study, published last week in the Annals of Surgery, say they looked at data from nearly 100,000 breast implant procedures gleaned from FDA-mandated postmarket studies for implants made by Johnson & Johnson's Mentor business, and by Allergan. The analysis showed that silicone implants are associated with higher rates of  Sjögren syndrome, scleroderma, rheumatoid arthritis, stillbirth, and melanoma. The researchers reported that 56% of the...
Source: MDDI - September 18, 2018 Category: Medical Devices Authors: Amanda Pedersen Tags: Implants Source Type: news