Tocilizumab May Improve Lung Function in Early Systemic Sclerosis Tocilizumab May Improve Lung Function in Early Systemic Sclerosis
Treatment with tocilizumab could stabilize or improve lung function in people with early interstitial lung disease associated with systemic sclerosis.Medscape Medical News (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - February 19, 2021 Category: Dermatology Tags: Rheumatology News Source Type: news
New research finds connection: Inflammation, metabolism and scleroderma scarring
(Michigan Medicine - University of Michigan) Study finds NAD+ break down leads to multi organ scarring, providing now a previously undiscovered pathogenic role of the enzyme CD38 in disease scarring. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 19, 2021 Category: International Medicine & Public Health Source Type: news
SARS-CoV-2 Pandemic Impacts on Systemic Sclerosis Patients SARS-CoV-2 Pandemic Impacts on Systemic Sclerosis Patients
What challenges have systemic sclerosis patients had to overcome due to the COVID-19 pandemic in terms of their disease management?Journal of Clinical Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 13, 2021 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news
Protein linked to progressive lung scarring in scleroderma patients
(Michigan Medicine - University of Michigan) Osteopontin is discovered as the culprit behind systemic sclerosis patients' main cause of death: lung fibrosis. However, a repurposed immunosuppressive drug may combat the pro-inflammatory protein. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 17, 2020 Category: International Medicine & Public Health Source Type: news
Older Age Onset of Systemic Sclerosis Older Age Onset of Systemic Sclerosis
Systemic sclerosis may more rapidly progress among individuals who develop the disease later in life.Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 1, 2020 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news
One step for fibrosis, one giant leap for scleroderma
(Medical University of South Carolina) At the Medical University of South Carolina, a team of researchers has demonstrated a " moonlighting " role for lysyl oxidase (LOX) in scleroderma. It was previously known that LOX crosslinked the connective tissue. However, this research showed that, independent of its crosslinking function, LOX plays multiple additional roles in promoting fibrosis in scleroderma, known as " moonlighting. " Furthermore, these researchers demonstrated that LOX could be a potential biomarker and target for antifibrotic therapy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 16, 2020 Category: International Medicine & Public Health Source Type: news
Interstitial lung disease associated with systemic sclerosis large burden
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - November 1, 2020 Category: Drugs & Pharmacology Source Type: news
Abatacept as Treatment for Diffuse Cutaneous Systemic Sclerosis Abatacept as Treatment for Diffuse Cutaneous Systemic Sclerosis
' Exploratory outcome measures during the open-label extension, including the composite ACR CRISS score, indicate that abatacept might promote overall global improvement in these participants. 'Medscape Medical News (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - October 29, 2020 Category: Dermatology Tags: Rheumatology News Source Type: news
Systemic Sclerosis Patients Share Their Needs in Treatment Trials Systemic Sclerosis Patients Share Their Needs in Treatment Trials
Patients with systemic sclerosis have variable disease progression but often experience debilitating fatigue, pain, and digestive issues; and they ' re extremely concerned about progressive organ damage.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 26, 2020 Category: Consumer Health News Tags: Rheumatology News Source Type: news
Stretches of repeating DNA predispose to systemic sclerosis
(University of Tsukuba) Researchers from the University of Tsukuba found that extended repeats of DNA in the gene FLI1 are associated with systemic sclerosis. By comparing the DNA of systemic sclerosis patients with healthy controls, they found that GA repeats over 22 are associated with the development of the disease as well as with a more severe outcome. These findings help us understand how FLI1 may contribute to the pathogenesis of systemic sclerosis. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 3, 2020 Category: Biology Source Type: news
Scleroderma: your questions about the autoimmune disease answered
Yale Medicine ’s Dr. Monique Hinchcliff, director of the Yale Scleroderma Program, offers valuable information about the difficult-to-diagnose disorder. (Source: Yale Science and Health News)
Source: Yale Science and Health News - July 15, 2020 Category: Universities & Medical Training Source Type: news
EC_approval_nintedanib_ILD_PF
European Commission approves third nintedanib indication in pulmonary fibrosis1The approval is for the treatment of adults with other chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype beyond idiopathic pulmonary fibrosis (IPF).1The decision is based on the results of the INBUILD ® trial, the first study to evaluate patients with a broad range of chronic fibrosing interstitial lung diseases (ILDs) and a progressive disease behavior.2Nintedanib is already approved in more than 80 countries for the treatment of idiopathic pulmonary fibrosis (IPF), and for systemic sclerosis-associated interstit...
Source: Boehringer Ingelheim Corporate News - July 15, 2020 Category: Research Source Type: news
Pulmonary Function Tests Not a Good Substitute in ILD Screening Pulmonary Function Tests Not a Good Substitute in ILD Screening
Any screening algorithm should include high-resolution CT, which is good at prognosticating disease, say the authors of a retrospective study of 212 patients with systemic sclerosis.Medscape Medical News (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - July 6, 2020 Category: Rheumatology Tags: Rheumatology News Source Type: news
In Scleroderma, GERD Questionnaires Are Essential Tools In Scleroderma, GERD Questionnaires Are Essential Tools
Every rheumatologist should be comfortable using a validated symptom scale for evaluating gastroesophageal reflux disease in patients with scleroderma, according to one expert.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 26, 2020 Category: Consumer Health News Tags: Rheumatology News Source Type: news
Be Vigilant for Scleroderma Renal Crisis Be Vigilant for Scleroderma Renal Crisis
A vexing feature of this emergency is that not uncommonly it actually precedes the diagnosis of scleroderma.Medscape Medical News (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - June 19, 2020 Category: Dermatology Tags: Rheumatology News Source Type: news
