Fight Aging! Newsletter, September 5th 2022

Conclusion Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome. The most interesting part of the data is perhaps the decline in microbial diversity, when considered against the gains elsewhere. Microbial diversity correlates with better health in epidemiological studies, but there isn't a good mechanistic understanding as to why this is the case, or what factors provoke diversity versus a lack of diversity. Transplanting B Cells from Old Mice to Young Mice to Investigate Details of B Cell Aging https://www.fightaging.org/archives/2022/09/transplanting-b-cells-from-old-mice-to-young-mice-to-investigate-details-of-b-cell-aging/ The varieties of B cell in the immune system participate in the immune response to pathogens by creating antibodies to match specific antigens, and spreading the information represented by that antibody to portions of the adaptive immune system capable of attacking threats. This is a very crude, high level summary of an enormously complex system. The fine details of how subsets of the B cell population generate suitable an...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs