Teprotumumab, Canagliflozin, and Kevin Pho Top AACE Agenda Teprotumumab, Canagliflozin, and Kevin Pho Top AACE Agenda
Graves'ophthalmopathy, type 2 diabetes treatment, social media matters, and much more to be featured at Los Angeles conference.Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - April 16, 2019 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Treatment success for diabetic kidney disease
Clinical trial findings inThe New England Journal of Medicine report that canagliflozin can reduce the risk of kidney and cardiac failure in patients with diabetes.iNews (Source: Society for Endocrinology)
Source: Society for Endocrinology - April 16, 2019 Category: Endocrinology Source Type: news

Canagliflozin Seems Effective for Patients With T2DM, Kidney Disease
MONDAY, April 15, 2019 -- Canagliflozin is associated with a reduced risk for renal and cardiovascular events for patients with type 2 diabetes and kidney disease, according to a study published online April 14 in the New England Journal of Medicine... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 15, 2019 Category: Pharmaceuticals Source Type: news

Diabetes Drug'Home Run' Curtailing Kidney Failure Risk Diabetes Drug'Home Run' Curtailing Kidney Failure Risk
Canagliflozin also showed cardiovascular benefits in the CREDENCE multicenter trial, with no imbalance in adverse events, investigators shared here at the nephrology world congress.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - April 15, 2019 Category: Cardiology Tags: Nephrology News Source Type: news

Common Diabetes Drug Invokana (canagliflozin) May Also Shield Kidneys, Heart
MONDAY, April 15, 2019 -- A common diabetes drug may also greatly reduce the odds for death from kidney failure and heart disease in diabetes patients with kidney disease, a new study finds. The news on Invokana (canagliflozin) is important,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 15, 2019 Category: General Medicine Source Type: news

INVOKANA ® (canagliflozin) Significantly Reduces the Risk of Renal Failure in Patients with Type 2 Diabetes and Chronic Kidney Disease in the Landmark Phase 3 CREDENCE Study
(Source: Johnson and Johnson)
Source: Johnson and Johnson - April 15, 2019 Category: Pharmaceuticals Source Type: news

A Diabetes Drug Called Invokana May Prevent or Slow Kidney Disease, a New Study Says
A drug that’s used to help control blood sugar in people with diabetes has now been shown to help prevent or slow kidney disease, which causes millions of deaths each year and requires hundreds of thousands of people to use dialysis to stay alive. Doctors say it’s hard to overstate the importance of this study, and what it means for curbing this problem, which is growing because of the obesity epidemic. The study tested Janssen Pharmaceuticals’ drug Invokana. Results were discussed Sunday at a medical meeting in Australia and published by the New England Journal of Medicine. About 30 million Americans and...
Source: TIME: Health - April 15, 2019 Category: Consumer Health News Authors: MARILYNN MARCHIONE / AP Tags: Uncategorized medicine onetime overnight Source Type: news

Janssen Submits Supplemental New Drug Application to U.S. FDA for INVOKANA ® (canagliflozin) for the Treatment of Chronic Kidney Disease in Patients with Type 2 Diabetes
(Source: Johnson and Johnson)
Source: Johnson and Johnson - March 28, 2019 Category: Pharmaceuticals Source Type: news

Diabetes drug alters vitamin D levels, possibly explaining increased bone fracture risk
Scientists found that the diabetes drug canagliflozin reduces vitamin D levels and calcium uptake, which may explain why this drug can increase the risk of bone fractures.  (Source: NIDDK News)
Source: NIDDK News - March 22, 2019 Category: Endocrinology Source Type: news

CANVAS: Reassuring Data on Stroke With Canagliflozin CANVAS: Reassuring Data on Stroke With Canagliflozin
More detailed data from the CANVAS program have been reported showing reassuring results on all stroke types and a significant reduction in hemorrhagic stroke.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 9, 2019 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Type 2 Diabetes Med Might Not Harm Bones After All
Canagliflozin (Invokana, Invokamet) is in a class of medications called SGLT-2 inhibitors. These drugs cause the kidneys to remove excess sugar from the blood and excrete it through urine, which lowers blood sugar levels. This class of drugs has been linked to a number of complications, including kidney injury and serious genital infections. (Source: WebMD Health)
Source: WebMD Health - January 3, 2019 Category: Consumer Health News Source Type: news

Study Eases Concern That Common Diabetes Med, Canagliflozin (Invokana, Invokamet), Might Harm Bones
THURSDAY, Jan. 3, 2019 -- If you have type 2 diabetes and you're taking canagliflozin to help control your blood sugar, a new study has some good news for you: The drug doesn't appear to raise the risk of bone fractures. Previously, research had... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 3, 2019 Category: General Medicine Source Type: news

Study Eases Concern That Common Diabetes Drug Canagliflozin (Invokana, Invokamet) Might Harm Bones
THURSDAY, Jan. 3, 2019 -- If you have type 2 diabetes and you're taking canagliflozin to help control your blood sugar, a new study has some good news for you: The drug doesn't appear to raise the risk of bone fractures. Previously, research had... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 3, 2019 Category: General Medicine Source Type: news

No Increased Fracture Risk With Canagliflozin in Type 2 Diabetes
WEDNESDAY, Jan. 2, 2019 -- Canagliflozin is not associated with increased fracture risk versus glucagon-like peptide-1 (GLP-1) agonists for middle-aged patients with type 2 diabetes, according to a study published online Jan. 1 in the Annals of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 2, 2019 Category: Pharmaceuticals Source Type: news

Canagliflozin does not increase fracture risk in diabetes patients
Canagliflozin treatment does not increase the risk of fractures in type-2 diabetes patients, according to research published inAnnals of Internal Medicine.MedicalXpress (Source: Society for Endocrinology)
Source: Society for Endocrinology - January 2, 2019 Category: Endocrinology Source Type: news

Canagliflozin Not Linked to Fractures in Large Database Study Canagliflozin Not Linked to Fractures in Large Database Study
Risk associated with SGLT2 inhibitor may be limited to patients with type 2 diabetes who have additional fracture risk.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 31, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Canagliflozin not associated with increased risk for fracture
(American College of Physicians) Compared with a glucagon-line peptide-1 (GLP-1) agonist, canagliflozin was not associated with an increased risk for fracture in patients with type 2 diabetes at relatively low risk for fracture. Findings from a multidatabase cohort study are published in Annals of Internal Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 31, 2018 Category: International Medicine & Public Health Source Type: news

Take this FDA-approved diabetes drug, and you might have to amputate your leg, warns the FDA
(Natural News) The U.S. Food and Drug Administration (FDA) has recently issued a black box warning against Johnson & Johnson’s Type 2 diabetes drug Invokana as the medication was found to increase the risk of amputation in patients. Data from two clinical trials showed that patients taking canagliflozin, the drug’s generic name, had higher incidence of amputations than... (Source: NaturalNews.com)
Source: NaturalNews.com - December 2, 2018 Category: Consumer Health News Source Type: news

Nov 2, 2018 This Week in Cardiology Nov 2, 2018 This Week in Cardiology
CV outcomes in patients with type 2 diabetes, canagliflozin, cardiorespiratory fitness, the value of randomized trials, and the most important paper of 2018 are reviewed in this week ’ s podcast.theheart.org on Medscape (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 2, 2018 Category: Consumer Health News Tags: Cardiology Commentary Source Type: news

Questions Raised About Invokana Label Expansion For CV Risk Reduction
Experts are raising questions about FDA's decision to expand the label of the diabetes drug Invokana to reduce the risk of cardiovascular events. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - November 1, 2018 Category: Pharmaceuticals Authors: Larry Husten, Contributor Tags: NYSE:LLY NYSE:JNJ Source Type: news

Canagliflozin (Invokana) Gets FDA Nod for CV Protection Canagliflozin (Invokana) Gets FDA Nod for CV Protection
The SGLT2 inhibitor is the first oral diabetes medication approved to reduce the risk of cardiovascular events in patients with type 2 diabetes and heart disease.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 31, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

FDA Clears Invokana for CV Prevention in T2D
(MedPage Today) -- First oral diabetes drug to win this indication (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - October 31, 2018 Category: American Health Source Type: news

FDA Clears Canagliflozin for CV Prevention in T2D
(MedPage Today) -- First oral diabetes drug to win this indication (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - October 31, 2018 Category: Endocrinology Source Type: news

U.S. FDA Approves INVOKANA(R) (canagliflozin) to Reduce the Risk of Heart Attack, Stroke or Cardiovascular Death in Adults with Type 2 Diabetes and Established Cardiovascular Disease
INVOKANA® is now the only oral diabetes treatment approved to reduce the risk of these cardiovascular events Approval aligns with ADA and AACE treatment guidance and supports use of INVOKANA® across a broad range of patients TITUSVILLE, N.J.,... Biopharmaceuticals, Endocrinology, Cardiology, FDA Janssen Pharmaceutical, INVOKANA, canagliflozin, diabetes (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - October 30, 2018 Category: Pharmaceuticals Source Type: news

U.S. FDA Approves INVOKANA ® (canagliflozin) to Reduce the Risk of Heart Attack, Stroke or Cardiovascular Death in Adults with Type 2 Diabetes and Established Cardiovascular Disease
(Source: Johnson and Johnson)
Source: Johnson and Johnson - October 30, 2018 Category: Pharmaceuticals Source Type: news

FDA Approves Invokana (canagliflozin) to Reduce the Risk of Heart Attack, Stroke or Cardiovascular Death in Adults with Type 2 Diabetes and Established Cardiovascular Disease
TITUSVILLE, NJ, October 30, 2018– The Janssen Pharmaceutical Companies of Johnson& Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved Invokana (canagliflozin) to reduce the risk of major adverse... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - October 30, 2018 Category: Drugs & Pharmacology Source Type: news

SGLT2 Inhibitor-Amputation Link in Diabetes -- Is it Hypovolemia? SGLT2 Inhibitor-Amputation Link in Diabetes -- Is it Hypovolemia?
Observational study finds an increased amputation risk with diuretic use in people with diabetes, suggesting that the hypovolemic mechanism may also explain the amputation risk seen with canagliflozin.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 2, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

EU Okays CV Benefit Labeling for Canagliflozin in Diabetes EU Okays CV Benefit Labeling for Canagliflozin in Diabetes
The European label for the SGLT2 inhibitor canagliflozin for type 2 diabetes will now include positive cardiovascular benefit results from the CANVAS trial, while a decision from the US FDA is forthcoming.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 21, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

How One Class Of Diabetes Medications May Lead To Flesh-Eating Genital Infections
If you are taking canagliflozin, dapagliflozin, empagliflozin, ertugliflozin, or any other sodium-glucose cotransporter-2 (SGLT2) inhibitor, you may want to pay attention to this FDA warning. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - September 1, 2018 Category: Pharmaceuticals Authors: Bruce Y. Lee, Contributor Source Type: news

Another SGLT2 That You Can Feel Safe Prescribing Another SGLT2 That You Can Feel Safe Prescribing
In regard to amputation risk (and despite a black box warning), it appears that canagliflozin is no less safe than other diabetes drugs.Medscape Internal Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 27, 2018 Category: Consumer Health News Tags: Internal Medicine Commentary Source Type: news

Trulicity Label Update; Canagliflozin Success for CKD; Capsaicin for Weight Loss
(MedPage Today) -- News and commentary from the endocrinology world (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - July 20, 2018 Category: Cardiology Source Type: news

Canagliflozin Renal Outcomes Study Is Halted Early for Efficacy Canagliflozin Renal Outcomes Study Is Halted Early for Efficacy
Hope that observed renoprotective effects of SGLT2 inhibitors will delay worsening of kidney disease in type 2 diabetes seems to be borne out, as the CREDENCE trial is stopped early.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 17, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Phase 3 CREDENCE Renal Outcomes Trial of INVOKANA ® (canagliflozin) is Being Stopped Early for Positive Efficacy Findings
(Source: Johnson and Johnson)
Source: Johnson and Johnson - July 16, 2018 Category: Pharmaceuticals Source Type: news

U.S. FDA Extends Review Timeline for INVOKANA ® (canagliflozin) Supplemental New Drug Application
(Source: Johnson and Johnson)
Source: Johnson and Johnson - July 13, 2018 Category: Pharmaceuticals Source Type: news

New Study Finds No Link Between Canagliflozin and Amputations New Study Finds No Link Between Canagliflozin and Amputations
A large observational study offers reassurance following the doubling of risk seen in CANVAS, although the investigator acknowledges amputations are still'the fly in the ointment'for this drug.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 25, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

No Greater Amputation Risk with Canagliflozin in T2D Patients
(MedPage Today) -- Real-world analysis done in over 100,000 canagliflozin users (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - June 24, 2018 Category: Pediatrics Source Type: news

Real-World Study of More than 700,000 People with Type 2 Diabetes (T2D) Shows No Increased Risk of Below-Knee Lower Extremity Amputations with INVOKANA ® (canagliflozin) Compared to Other Diabetes Medications
(Source: Johnson and Johnson)
Source: Johnson and Johnson - June 24, 2018 Category: Pharmaceuticals Source Type: news

Real-World Evidence Shows Oral INVOKANA ® (canagliflozin) Results in Greater Weight Loss and Treatment Adherence Than Injectable GLP-1 Receptor Agonists in Type 2 Diabetes Patients
(Source: Johnson and Johnson)
Source: Johnson and Johnson - June 23, 2018 Category: Pharmaceuticals Source Type: news

New Late-Breaking Data on the Use of Type 2 Diabetes Treatment INVOKANA ® (canagliflozin) in the Real World Will Be Presented at the American Diabetes Association’s 78th Annual Scientific Sessions
(Source: Johnson and Johnson)
Source: Johnson and Johnson - June 8, 2018 Category: Pharmaceuticals Source Type: news

Hormonal Mechanism Could Explain Canagliflozin's Fracture Risk Hormonal Mechanism Could Explain Canagliflozin's Fracture Risk
If proven, the problem might be managed by measuring 1,25-dihydroxyvitamin D levels in patients and providing calcitriol or vitamin D supplementation for those deficient.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 15, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Real-World Study Shows INVOKANA ® (canagliflozin) 300mg Demonstrates Better Blood Glucose Control Than Farxiga® (dapagliflozin) 10mg in Patients with Type 2 Diabetes
(Source: Johnson and Johnson)
Source: Johnson and Johnson - April 27, 2018 Category: Pharmaceuticals Source Type: news

Invokana Helps Kidneys Even in Diabetic CKD
(MedPage Today) -- Subanalysis of CANVAS program shows slower progression, fewer events (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - April 13, 2018 Category: Cardiology Source Type: news

INVOKANA ® (canagliflozin) Demonstrated Significant Renal Protective Benefits in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease
(Source: Johnson and Johnson)
Source: Johnson and Johnson - April 12, 2018 Category: Pharmaceuticals Source Type: news

Canagliflozin May Have Most Benefit in Diabetes With HF: CANVAS Canagliflozin May Have Most Benefit in Diabetes With HF: CANVAS
Exploratory analysis of CANVAS data shows canagliflozin reduced HF hospitalization and cardiovascular death in type 2 diabetes regardless of HF status, and hints at even more benefit for those with HF.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 15, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news

INVOKANA ® (canagliflozin) Significantly Reduces the Risk of Heart Failure- Related Outcomes in Type 2 Diabetes Patients at Risk for or With a History of Cardiovascular Disease
(Source: Johnson and Johnson)
Source: Johnson and Johnson - March 11, 2018 Category: Pharmaceuticals Source Type: news

New Late-Breaking XARELTO ® (rivaroxaban) and INVOKANA® (canagliflozin) Data to be Presented at the American College of Cardiology's Annual Scientific Session
(Source: Johnson and Johnson)
Source: Johnson and Johnson - February 26, 2018 Category: Pharmaceuticals Source Type: news

Canagliflozin Linked to Fewer HF Admissions Than Other Type 2 Diabetes Drugs Canagliflozin Linked to Fewer HF Admissions Than Other Type 2 Diabetes Drugs
Reuters Health Information (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - February 20, 2018 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

INVOKANA(R) (canagliflozin) Significantly Improved Renal Outcomes and Demonstrated Potential Renal Protective Effects in Patients with Type 2 Diabetes Who Have or Are at Risk for Cardiovascular Disease
Late-breaking renal data from the integrated CANVAS Program presented at the American Society of Nephrology Kidney Week 2017 Annual Meeting RARITAN, N.J. and NEW ORLEANS, Nov. 3, 2017 -- (Healthcare Sales & Marketing Network) -- Janssen Research & Deve... Biopharmaceuticals, Nephrology Janssen, INVOKANA, canagliflozin (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - December 5, 2017 Category: Pharmaceuticals Source Type: news

CANVAS: No Difference in Canagliflozin Effects by Prior CV Status CANVAS: No Difference in Canagliflozin Effects by Prior CV Status
A new analysis of CANVAS finds that canagliflozin reduces CV and renal risks whether the type 2 diabetes patients had prior CVD or not, although a discussant queries benefit in primary prevention.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 27, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news