Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics
Clostridioides difficile is a Gram-positive anaerobe that can cause a spectrum of disorders that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium produces up to three toxins, which are considered the major virulence factors in C. difficile infection. These toxins promote inflammation, tissue damage and diarrhoea. In this Review, we highlight recent biochemical and structural advances in our understanding of the mechanisms that govern host-toxin interactions. Understanding how C. difficile toxins affect the host forms a foundation for developing novel strategies for treatment and preven...
Source: Current Awareness Service for Health (CASH) - May 20, 2022 Category: Consumer Health News Source Type: news

Clostridium difficile Infection Does Not Impact Outcomes in Stroke Patients
This study investigates incidence, patient characteristics, clinical features, and outcomes of CDI following stroke, including ischemic stroke (IS), intracerebral hemorrhage (ICH), and aneurysmal subarachnoid hemorrhage (SAH).; (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 20, 2022 Category: Consumer Health News Source Type: news

Notes from the Field: Escherichia coli O157:H7 Outbreak in Children with Clostridioides difficile Colonization Associated with an Improperly Treated Swimming Pool - Pennsylvania, June 2021
This report describes an E. coli outbreak associated with a swimming pool. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - May 19, 2022 Category: American Health Tags: C. difficile Children's Health Clostridium difficile Infection E. coli Infection MMWR Morbidity & Mortality Weekly Report Outbreaks Recreational Water Illness (RWI) Water Treatment Water-Related Diseases Source Type: news

Understanding Toxin Testing Results for C diff Understanding Toxin Testing Results for C diff
Testing stool samples for C difficile exotoxins A and B is frequently used to diagnose a C difficile infection, but clinicians need a greater understanding of what the results mean.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 6, 2022 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Pigs can pass deadly superbugs to people, study reveals
Research into C difficile found antibiotic resistance is growing as a result of overuse on farm stockScientists have uncovered evidence that dangerous versions of superbugs can spread from pigs to humans. The discovery underlines fears that intensive use of antibiotics on farms is leading to the spread of microbes resistant to them.The discovery of the link has been made by Semeh Bejaoui and Dorte Frees of Copenhagen University and Soren Persson at Denmark ’s Statens Serum Institute and focuses on the superbugClostridioides difficile, which is considered one of the world ’s major antibiotic resistance threats.Continue ...
Source: Guardian Unlimited Science - April 24, 2022 Category: Science Authors: Robin McKie Science editor Tags: Antibiotics Farming Infectious diseases Microbiology Science Health Epidemics UK news Medical research World news Source Type: news

Cleaning and disinfecting surfaces in hospitals and long-term care facilities for reducing hospital- and facility-acquired bacterial and viral infections: a systematic review
Conclusion: Ten c-RCTs focused on reducing multiple MDROs and/or HAIs and four had significant reductions. Three c-RCTs reported only patient MRSA colonization rates (o ne significant reductions), and one focused on C. difficile (no significant differences). Standardized primary and secondary outcomes are required for future c-RCTs including detailed biofilm cleaning/disinfection interventions. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 21, 2022 Category: Consumer Health News Source Type: news

Recently Discharged Patients Pose Risk for Spreading C. Difficile Infection
FRIDAY, April 15, 2022 -- Asymptomatic patients recently discharged from a hospital may be a source of household transmission of Clostridioides difficile infection (CDI), according to a study published in the May issue of Emerging Infectious... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 15, 2022 Category: Pharmaceuticals Source Type: news

Asymptomatic C. difficile Carriers May Infect Their Families Asymptomatic C. difficile Carriers May Infect Their Families
Hospitalized asymptomatic C. difficile carriers may infect people they live with after they return home, new research suggests.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - April 14, 2022 Category: Gastroenterology Tags: Infectious Diseases News Source Type: news

The Connection Between IBD and Aging
Inflammatory bowel disease (IBD) has long been thought of as an ailment of middle, or even young, adulthood. The chronic illness—which includes Crohn’s disease and ulcerative colitis, and can cause abdominal pain, diarrhea, bleeding, and decreased quality of life—impacts about 3.1 million people in the U.S. However, it is far from a disease only of the young and middle-aged. More than a quarter of people with IBD are elderly, a figure that is projected to climb to 30% by 2030, according to a 2021 Gastroenterology & Hepatology article. Even more underappreciated is the growing population of people who ...
Source: TIME: Health - April 8, 2022 Category: Consumer Health News Authors: Katherine Harmon Courage Tags: Uncategorized Disease healthscienceclimate Source Type: news

A comparative analysis of machine learning approaches to predict C. difficile infection in hospitalized patients
Conclusions: MLAs can predict future CDI in hospitalized patients using just 6 hours of data. In clinical practice, a machine-learning based tool may support prophylactic measures, earlier diagnosis, and more timely implementation of infection control measures. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 21, 2022 Category: Consumer Health News Source Type: news

What's the Future of Microbiome Therapies in CDI, Cancer? What's the Future of Microbiome Therapies in CDI, Cancer?
Preventive treatments for C difficile recurrence are in phase 3 trials. Oncologists are also investigating microbiome-based differences in treatment response.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 18, 2022 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Aerosolized Hydrogen Peroxide Can Significantly Reduce C. difficile Infections Aerosolized Hydrogen Peroxide Can Significantly Reduce C. difficile Infections
Aerosolized hydrogen peroxide is a new tool in fighting C. difficile in healthcare settings.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 18, 2022 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Hygienic monitoring in long-term care facilities using ATP, crAssphage, and human noroviruses to direct environmental surface cleaning
Conclusions: Surfaces with high levels of ATP and crAssphage were identified. Quantifying levels of contamination longitudinally and before and after cleaning might enhance infection prevention and control procedures for reducing diarrheal illnesses in LTC facilities. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 14, 2022 Category: Consumer Health News Source Type: news

C difficile Vaccine: CLOVER Trial Shows Mixed Results C difficile Vaccine: CLOVER Trial Shows Mixed Results
There ' s mixed news from Pfizer on results from the CLOVER trial of their candidate vaccine for preventing C diff infection.Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - March 8, 2022 Category: Internal Medicine Tags: Infectious Diseases News Source Type: news

What Causes Rectal Prolapse?
Discussion Rectal prolapse is defined as a herniation of the rectum through the anal verge. In children it is also usually mucosal prolapse and not full thickness. Partial or mucosal prolapse usually is seen as radial folds occurring 1 – 2.5 cm from the anal verge. Full thickness will protrude more than 5 cm. It affects genders equally and occurs most commonly in children under age 4. This is due to vertical course and low position of the anus, looser supporting tissues and less muscular support. These children are more likely to have prolapse but are less likely to have it recur. After age 4 the rectum takes the adu...
Source: PediatricEducation.org - February 28, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news