Surveillance for Healthcare-Associated Infections: Hospital-Onset Adult Sepsis Events Versus Current Reportable Conditions
Conclusions CDC's HO-ASE definition detects many serious nosocomial infections missed by currently reportable HAIs. HO-ASE surveillance could increase the efficiency and clinical significance of surveillance while identifying new targets for prevention. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 8, 2021 Category: Consumer Health News Source Type: news

Antimicrobial stewardship and infection prevention interventions targeting healthcare-associated Clostridioides difficile and carbapenem-resistant Klebsiella pneumoniae infections: a scoping review
Conclusion: This scoping review identified the AMS and IP interventions targeting C. difficile and CRKP in healthcare settings and described their key outcomes. The application of behaviour change principles in AMS and IP interventions appears to be limited. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 10, 2021 Category: Consumer Health News Source Type: news

Fecal Transplants: a New Treatment for IBD
Linda Ann Sasser has had ulcerative colitis since she was 20, but it wasn’t until May 2019, about 30 years later, that her condition hit a low point: not only did she have a major flare-up of chronic inflammatory bowel disease (IBD), but on top of it, she had Clostridioides difficile (or C. diff), a highly contagious bacterial infection that causes severe diarrhea and inflammation of the colon. “I became really, really sick with bloody diarrhea 30 times a day and chronic stomach pain,” Sasser says. While hospitalized for 12 days, she was given oral steroid medications, which didn’t help, then IV ste...
Source: TIME: Health - September 9, 2021 Category: Consumer Health News Authors: Stacey Colino Tags: Uncategorized Disease feature Source Type: news

Costs Associated with the Treatment of Clostridioides Difficile Infections
Background: Clostridioides difficile , as the main cause of infectious diarrhoea in hospitalised patients, is a considerable challenge for medical personnel (hospital environment) who have direct contact with the patient, as well as being of interest to public health specialists. Financial issues related to the occurrence of the above-mentioned micro-organism are being increasingly raised. Due to the scale of the phenomenon, we are beginning to pay attention to the significant system costs caused by the diagnosis and treatment of CDI infection and its complications. Studies indicate that the nosocomial infection of C. diff...
Source: Current Awareness Service for Health (CASH) - August 12, 2021 Category: Consumer Health News Source Type: news

Minimising Clostridioides difficile and Gram-negative Bloodstream Infections, NHS England
This document sets the thresholds for each trust, together with the methodology used to identify and minimise rates of both Clostridioides difficile (C. difficile) and Gram-negative bloodstream infections. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 10, 2021 Category: Consumer Health News Source Type: news

Secondary Oral Vancomycin PPX Reduces Recurrent C Diff Infection Secondary Oral Vancomycin PPX Reduces Recurrent C Diff Infection
Pediatric patients with C difficile infection have a significantly lower risk of recurrence within 8 weeks of antibiotic exposure when they receive secondary oral vancomycin prophylaxis, a small study suggests.Reuters Health Information (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - August 2, 2021 Category: Infectious Diseases Tags: Gastroenterology News Source Type: news

Antimicrobial prescribing for C. difficile infection
NICE has updated its antimicrobial prescribing guideline for C. difficile, which sets out a strategy for managing infection in adults, young people and children aged 72 hours and over, in community and hospital settings. (Source: NHS Networks)
Source: NHS Networks - July 28, 2021 Category: UK Health Source Type: news

C Diff Eradication Not Necessary for Clinical Cure C Diff Eradication Not Necessary for Clinical Cure
The findings support existing guidance not to test for presence of C difficile after treatment if the patient is asymptomatic.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - July 26, 2021 Category: Gastroenterology Tags: Infectious Diseases News Source Type: news

First Light Diagnostics Receives FDA Clearance for its Rapid Clostridiodes difficile Test on the MultiPath(R) Analyzer
First FDA cleared product based on the Company's proprietary MultiPath technology CHELMSFORD, Mass., July 20, 2021 -- (Healthcare Sales & Marketing Network) -- First Light Diagnostics is developing and commercializing breakthrough automated diagnostic ... Diagnostics, FDA First Light Diagnostics, SensiTox, C. difficile test, Clostridium difficile (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 20, 2021 Category: Pharmaceuticals Source Type: news

Haem is crucial for medium-dependent metronidazole resistance in clinical isolates of Clostridioides difficile
Conclusions: Our data demonstrate that haem is crucial for medium-dependent metronidazole resistance in C. difficile. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 16, 2021 Category: Consumer Health News Source Type: news

Guidance Updated for Managing C. difficile Infection in Adults
MONDAY, July 12, 2021 -- Use of fidaxomicin and bezlotoxumab is suggested in specific cases for management of Clostridioides difficile infection (CDI), according to a clinical practice guideline update issued by the Infectious Diseases Society of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 12, 2021 Category: Pharmaceuticals Source Type: news

Microbiome startup Seres Therapeutics expands Nestl é Health partnership
As microbiome startup Seres Therapeutics gets ready to bring its C. difficile treatment to the FDA, it has expanded its partnership with Nestl é Health, which is providing Seres with up to $500 million to commercialize the drug. $MCRB (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - July 2, 2021 Category: American Health Authors: Rowan Walrath Source Type: news

New Guideline for Prevention, Diagnosis, and Treatment of C diff New Guideline for Prevention, Diagnosis, and Treatment of C diff
New guidelines on C difficile from the American College of Gastroenterology offer recommendations on prevention, diagnosis, and treatment, along with guidance for special populations.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - June 25, 2021 Category: Gastroenterology Tags: Gastroenterology News Source Type: news

Diagnosis and Management of C. Difficile in Patients With IBD Diagnosis and Management of C. Difficile in Patients With IBD
Clostridioides difficile infection is a common but serious complication of IBD, and can present atypically. Review the risk factors, diagnosis, and management of CDI in IBD patients in this article.Current Opinion in Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 23, 2021 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

New ACG Guidelines on'C difficile': Key Takeaways New ACG Guidelines on'C difficile': Key Takeaways
Dr David Johnson highlights the practice-changing implications of expert recommendations on diagnosing and managing these common infections.Medscape Gastroenterology (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - June 18, 2021 Category: Gastroenterology Tags: Gastroenterology Commentary Source Type: news

Study reveals new therapeutic target for C. difficile infection
(University of California - Irvine) A new study paves the way for the development of next generation therapeutics for the prevention and treatment of Clostridioides difficile infection (CDI), the most frequent cause of healthcare-acquired gastrointestinal infections and death in developed countries. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 18, 2021 Category: Infectious Diseases Source Type: news

Risk factors for Clostridioides difficile colonization among hospitalized adults: A meta-analysis and systematic review
Objective: To identify risk factors for asymptomatic Clostridioides difficile colonization among hospitalized adults utilizing a meta-analysis, which may enable early identification of colonized patients at risk of spreading C difficite. Design: Meta-analysis and systematic review. Methods: We systematically searched MEDLINE, Scopus, Web of Science, and EMBASE from January 1,1975, to February 15, 2020, for articles related to C difficile colonization among hospitalized adults. Studies with multivariable analyses evaluating risk factors for asymptomatic colonization were eligible. Results: Among 5,506 studies identified in ...
Source: Current Awareness Service for Health (CASH) - June 17, 2021 Category: Consumer Health News Source Type: news

Evaluating the effect of automated hand hygiene technology on compliance and C. difficile rates in a long-term acute care hospital
Hand hygiene compliance impacts the prevalence of health care acquired infections. • The study evaluated a hand hygiene technology at a long-term acute care hospital. • The technology significantly increased hand hygiene compliance. • The increased hand hygiene produced a significant decrease in C. difficile incidence. Compliance with hand hygiene (HH) standards is a critica l component to reducing the prevalence of Health Care Acquired Infections (HAIs). The use of HH technologies is increasing and studies examining the success of these technologies on HH compliance and HAIs are important to inform standard...
Source: Current Awareness Service for Health (CASH) - June 17, 2021 Category: Consumer Health News Source Type: news

Using a nurse-initiated bedside tool to decrease inappropriate testing for Clostridioides difficile in hospital settings
This study evaluated a paper-based bedside C. difficile screening tool on the number of C. difficile laboratory tests performed and number of C. difficile infection (CDI) diagnoses. Nurses used the tool to determine whether stool should be sent for C. difficile testing. The tool provided indications for stool testing. We collected data on the number of C. difficile stool tests performed and CDI diagnoses for nine months before (PreT) and after (PostT) tool implementation in the hospital. We found a 31% reduction in the mean monthly number of C. difficile tests performed (37 PreT to 25 PostT) and a 56% reduction in CDI diag...
Source: Current Awareness Service for Health (CASH) - June 17, 2021 Category: Consumer Health News Source Type: news

MD Anderson research highlights for June 16, 2021
(University of Texas M. D. Anderson Cancer Center) The University of Texas MD Anderson Cancer Center's Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts. Current advances include a new combination therapy for acute myeloid leukemia (AML), a greater understanding of persistent conditions after AML remission, the discovery of a universal biomarker for exosomes, the identification of a tumor suppressor gene in hepatocellular carcinoma (HCC) and characterization of a new target to treat Clostridioides difficile (C. difficile) inf...
Source: EurekAlert! - Cancer - June 16, 2021 Category: Cancer & Oncology Source Type: news

Fecal Microbiota Transplantation is Poised for a Makeover
With multiple microbiota therapeutics in the pipeline for recurrent Clostridium difficile infection, clinicians foresee a shift in treatment options for the condition. (Source: The Scientist)
Source: The Scientist - June 1, 2021 Category: Science Tags: Bio Business Magazine Issue Source Type: news

Impact of COVID-19 prevention measures on risk of health care-associated Clostridium difficile infection, American Journal of Infection Control
The objective of this study was to establish whether such strategies can reduce health care associated C difficile infection (HA-CDI) incidence. We found that, during the pandemic (2020) HA-CDI incid ence was significantly lower with respect to the previous years. This work demonstrates that maintaining this level of attention regarding control activities related to prevention of microorganism transmission significantly reduce HA-CDI and related expenses in terms of health costs and human lives. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 13, 2021 Category: Consumer Health News Source Type: news

Randomised clinical trial: a 12-strain bacterial mixture versus faecal microbiota transplantation versus vancomycin for recurrent Clostridioides difficile infections, Alimentary pharmacology & therapeutics
Background: A defined bacterial mixture could be a safer alternative to faecal microbiota transplantation (FMT).; Aims: To compare the efficacy of a 12-strain mixture termed rectal bacteriotherapy with either FMT or vancomycin for recurrent Clostridioides difficile infection (CDI) in an open-label 3-arm randomised controlled trial.; Methods: We screened all individuals positive for C difficile from May 2017 to March 2019. Persons with laboratory-confirmed recurrent CDI were included. Before FMT and rectal bacteriotherapy, we pre-treated with vancomycin for 7-14 days. Rectal bacteriotherapy was applied by enema on three con...
Source: Current Awareness Service for Health (CASH) - May 13, 2021 Category: Consumer Health News Source Type: news

Bacterial Mixture vs FMT vs Vancomycin for C. diff Infection Bacterial Mixture vs FMT vs Vancomycin for C. diff Infection
Might rectal bacteriotherapy be a safer alternative to fecal microbiota transplantation for recurrent C. difficile infection?Alimentary Pharmacology & Therapeutics (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - May 10, 2021 Category: Intensive Care Tags: Gastroenterology Journal Article Source Type: news

90-Day Specific Readmission for Clostridium difficile Infection After Hospitalization With an Inflammatory Bowel Disease Flare: Outcomes and Risk Factors, Inflammatory Bowel Diseases
Conclusions The 90-day CDI-specific readmission rate after the index admission of IBD flares was 0.1%. We found risk factors for CDI-associated readmissions such as history of Parkinson's disease, prior CDI, HIV-positive status, and alcohol abuse disorder. Finally, our study also revealed a high health care cost, charges, and burden. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news

The Impact of Clinical Decision Support Alerts on Clostridioides difficile Testing: A Systematic Review, Clinical Infectious Diseases
Conclusions The use of electronic alerts for diagnostic stewardship for C. difficile was associated with reductions in CDI testing, the proportion of inappropriate CDI testing, and rates of CDI in most studies. However, broader concerns related to alerts remain understudied, including unintended adverse consequences and alert fatigue. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news

Can patient-reported room cleanliness measures predict hospital-acquired C. difficile infection? A study of acute care facilities in New York state, American Journal of Infection Control
This study examined the relationship between patient-reported room cleanliness, from the Hospital Consumer Assessment of Healthcare providers and Systems survey, and hospital-acquired C. difficile infection (HA-CDI) rates in NYS acute care hospitals. A random-effects regression analysis comp ared the percentage of patients indicating their room was " always " and " sometimes/never " kept clean to that facility's average HA-CDI rates, controlling for known predictors. A higher percentage of patients reporting their room was " always " kept clean was associated with significantly lower rates of ...
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news

The effect of a microbial ecosystem therapeutic (MET-2) on recurrent Clostridioides difficile infection: a phase 1, open-label, single-group trial, The lancet
This study is registered with ClinicalTrials.gov, NCT02865616 FINDINGS: Between Sept 19, 2018, and Feb 28, 2020, we enrolled 19 adult patients with at least two episodes of mild to moderate C difficile infection (median age 65 years [IQR 56-67]; 12 women [63%], seven men [37%]). Recurrent C difficile infection was absent at day 40 in 15 (79%) of 19 patients after initial treatment, increasing to 18 (95%) 40 days after retreatment. No mortality associated with C difficile infection, infections associated with MET-2 treatment, or other serious adverse events were observed. The most common self-limited, mild to moderate sympt...
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news

Perils and pitfalls of probiotic quasi-experimental studies for primary prevention of Clostridioides difficile infection: A review of the evidence, American Journal of Infection Control
Quasi-experimental studies (QES) are valuable when RCTs are not feasible. • We review QES of probiotics given to high-risk patients to prevent CDI. • Probiotics were given either hospital-wide or only at a ward-level. • 50%-60% of probiotic studies found significantly reduced CDI rates. Primary prevention of Clostridioides (Clostridium) difficile infections (CDI) is an important but challenging infection control goal for hospitals and health care facilities. Enhanced infection control protocols have reduced CDI rates, but the problem persists and administration of probiotics to patients at risk could be very...
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news

Unintended consequences of infection prevention and control measures during COVID-19 pandemic, American Journal of Infection Control
The impact of a multimodal infection control strategy originally designed for containment of COVID-19 on the rates of other hospital-acquired-infections (HAIs) was evaluated over a 7-month period across the largest healthcare system in Singapore. • During the COVID-19 pandemic, methicillin-resistant Staphylococcus aureus acquisition rates declined significantly, together with central-line-associated-bloodstream infection rates; likely due to increased compliance with standard precautions. • Enhanced infection control measures resulted in the unintended positive consequences of containing health care-associated re...
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news

What Are Toxin-Mediated Diseases?
Discussion A poison is a generic term for “a substance with an inherent property that tends to destroy life or impair health.” A toxin is more specific and is “any poison produced by an organism, characterized by antigenicity in certain animals and high molecular weight, and including the bacterial toxins that are the causative agents of tetanus, diphtheria, etc., and such plant and animal toxins as ricin and snake venom.” A toxin does not include those substances that are made synthetically produced. Venom is also a toxin that is used by animals and insects for predation or defense which can cause ...
Source: PediatricEducation.org - April 12, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Healthcare-associated infections
Clostridioides difficile (C. difficile), methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) are bacterial infections that commonly occur as a direct result of healthcare interventions (such as medical or surgical treatment), or from being in contact with a healthcare setting. They are the most well-known healthcare-associated infections (HCAIs). HCAIs pose a serious risk to patients, staff and visitors, can incur high costs for the NHS, and can cause significant morbidity to those infected. The emergence of new infections also poses a risk to patients and staff, as highlighted by the transmis...
Source: Current Awareness Service for Health (CASH) - March 26, 2021 Category: Consumer Health News Source Type: news

Universal screening for Clostridioides difficile at an urban academic medical center, Infection Control & Hospital Epidemiology 42(3): 351-352
We implemented universal inpatient Clostridioides difficile screening at an 800-bed hospital. Over 3 years, 2,010 of 47,048 screening tests (4.2%) were positive, with significantly higher rates of C. difficile colonization on transplant units than medical-surgical units: 5.4% (152 of 2,801) versus 4.3% (880 of 20,564), respectively (P =.005). Compliance with screening ranged from 79% to 96%. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 17, 2021 Category: Consumer Health News Source Type: news

Antibiotic Prescribing Choices and Their Comparative C. Difficile Infection Risks: A Longitudinal Case-Cohort Study, Clinical Infectious Diseases 72(5): 836-844
Conclusions C. difficile infection risk increases with antibiotic duration, and there are wide disparities in risks associated with antibiotic courses used for similar indications. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 17, 2021 Category: Consumer Health News Source Type: news

Impact of a C. difficile infection (CDI) reduction bundle and its components on CDI diagnosis and prevention, American Journal of Infection Control 49(3): 319-326
A C. difficile Infection reduction bundle showed variable impact. • A 75% decrease in hospital-associated C. difficile infection post-implementation was observed for one of the hospitals • Processes and intermediate outcomes should be critically evaluated and deconstructed Published bundles to reduce Clostridioides difficile Infection (CDI) frequently lack inf ormation on compliance with individual elements. We piloted a computerized clinical decision support-based intervention bundle and conducted detailed evaluation of several intervention-related measures. A quasi-experimental study of a bundled intervention w...
Source: Current Awareness Service for Health (CASH) - March 17, 2021 Category: Consumer Health News Source Type: news

Peggy Lillis Foundation and Ferring Pharmaceuticals Partner to Support...
Peggy Lillis Foundation for C. diff Education & Advocacy (PLF), the leading patient organization combating C. difficile infections (CDI), partners with Ferring Pharmaceuticals through a new...(PRWeb March 11, 2021)Read the full story at https://www.prweb.com/releases/peggy_lillis_foundation_and_ferring_pharmaceuticals_partner_to_support_patients_with_c_difficile_infection/prweb17784316.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - March 11, 2021 Category: Pharmaceuticals Source Type: news

Common Antibiotics for Diverticulitis Have Higher C difficile Risks Common Antibiotics for Diverticulitis Have Higher C difficile Risks
Dr David Johnson comments on new data indicating that it may be time to move away from metronidazole plus a fluoroquinolone in certain patients.Medscape Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 25, 2021 Category: Consumer Health News Tags: Gastroenterology Commentary Source Type: news

Faecal microbiota transplant for recurrent or refractory Clostridioides difficile infection, Medtech innovation briefing [MIB247]
The main points from the evidence summarised in this briefing are from 6 studies (1 network meta-analysis, 4 systematic reviews and a prospective registry) including a total of 7,314 people with recurrent or refractory C. difficile infection. They show that FMT is more effective than commonly used antibiotics such as vancomycin and fidaxomicin in people with recurrent or refractory C. difficile infection. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news

Transmission Dynamics of Clostridioides difficile in 2 High-Acuity Hospital Units, Clinical Infectious Diseases 72: S1-S7
Conclusions Although prevalence was similar between the units, there were important differences in the rates of transmission and clearance. Influential factors may include antimicrobial exposure or other patient-care factors. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news

Shortcourse versus longcourse antibiotic treatment in patients with uncomplicated gramnegative bacteremia: A systematic review and metaanalysis, Journal of Clinical Pharmacy & Therapeutics 46(1): 173-180
What is known and objective: Gram ‐negative bacteremia remains a major health problem around the world. The optimal duration of antibiotic treatment has been poorly defined, and there are significant differences of opinion between clinicians. We conducted this systematic review and meta‐analysis to compare the clinical outcomes of short‐course and long‐course treatments in patients with uncomplicated gram‐negative bacteremia. Methods: We searched public databases (PubMed, EMBASE and Cochrane Library) to identify eligible studies. The primary outcomes were all‐cause mortality and the incidence of recurrent bacte...
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news

Toxic Clostridioides (formerly Clostridium) difficile colitis: No longer a diarrhea associated infection, American journal of surgery 221(1): 240-242
Conclusion: CDI must be suspected in patients who rapidly develop abdominal distention, vague abdominal complaints or change in bowel function even in the absence of diarrhea, especially if coupled with multi-system organ failure. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news

Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial, American journal of respiratory and critical care medicine 203(2): 202-210.
Rationale: Although early antimicrobial discontinuation guided by procalcitonin (PCT) has shown decreased antibiotic consumption in lower respiratory tract infections, the outcomes in long-term sepsis sequelae remain unclear. Objectives: To investigate if PCT guidance may reduce the incidence of long-term infection-associated adverse events in sepsis. Methods: In this multicenter trial, 266 patients with sepsis (by Sepsis-3 definitions) with lower respiratory tract infections, acute pyelonephritis, or primary bloodstream infection were randomized (1:1) to receive either PCT-guided discontinuation of antimicrobials or stand...
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news

Association between Antibiotic Consumption and Incidence of Clostridioides difficile Infection in a Hospital. Journal of Korean medical science 35(47): e407
Previous exposure to antimicrobials is a major risk factor for Clostridioides difficile infection (CDI). Antibiotic prescription and C. difficile toxin assay records of patients admitted to a tertiary hospital in Korea from 2009 to 2013 were collected to investigate the association between antibiotic consumption and CDI incidence. A Spearman's correlation analysis between CDI incidence (positive result of toxin assay/10,000 admissions) and antibiotic consumption (defined daily dose/1,000 patient-days) was performed on a monthly basis. Using the matched month approach, we found a significant correlation between CDI rate and...
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news

A syndrome-based approach to antimicrobial stewardship in an Arizona skilled nursing facilityMoving the needle through quality improvement. American journal of infection control 48(12): 1537-1539
In 2015, an intervention to reduce unnecessary antibiotic prescribing for suspect urinary tract infection (UTI) was implemented in an Arizona skilled nursing facility. • Intervention included use of a 48[HYPHEN]hour enhanced observation protocol instead of urine culturing in low infection likelihood scenarios (eg, confusion without localizing signs of infection) and monthly feedback to providers on culturing and prescribing patterns. • In the 2 years following implementation of the intervention, antibiotic prescribing for suspect UTIs decreased by 85%, and C. difficile incidence by 86%, with no associated uroseps...
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news

Using diagnostic stewardship to reduce rates, healthcare expenditures and accurately identify cases of hospital-onset Clostridioides difficile infection, Infection Control & Hospital Epidemiology 42(1): 51-56
Conclusions: Initiatives to decrease risk for CDI and diagnostic stewardship of C. difficile stool NAAT significantly reduced HO-HCFA CDI rates, detection of potential false-positives associated with laxative use, and lowered healt hcare costs. Diagnostic stewardship itself had the most dramatic impact on outcomes observed and served as an effective tool in reducing HO-HCFA CDI rates. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news

Clostridium difficile Infection Reservoirs Within an Acute Rehabilitation Environment, American Journal of Physical Medicine & Rehabilitation 100(1): 44-47
Conclusions: Nonsporicidal disinfectant was not effective on hospital floors. Sporicidal disinfection of the floor is important when rates of C difficile infection are increased. Wheelchairs are complex devices and difficult to properly clean. The hospital purchased an ultraviolent device for wheelchair cleaning with a subsequent reduction in spores on repeat cultures. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news

Cost Consequences for the NHS of Using a Two-Step Testing Method for the Detection of Clostridium difficile with a Point of Care, Polymerase Chain Reaction Test as the First Step
The two-step, POCT strategy was estimated to save £ 283,282 per 1000 hospitalized NHS patients with suspected infectious diarrhoea. Sensitivity analysis indicated that the turnaround time for the POCT was the largest driver for cost savings. Providing the POCT has sufficiently high diagnostic accuracy for detecting C. difficile, the two-step, POCT strategy for CDI identification is likely to be cost saving for NHS hospitals with an offsite laboratory. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 14, 2021 Category: Consumer Health News Source Type: news

An Analysis of Clostridium difficile Environmental Contamination During and After Treatment for C difficile Infection
There were significant reductions in C difficile recovery from both faeces and the environment around fidaxomicin versus vancomycin/metronidazole recipients. Therefore, fidaxomicin treatment may lower the C difficile transmission risk by reducing excretion and environmental contamination. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 14, 2021 Category: Consumer Health News Source Type: news

Study reveals new details about how bacterial toxins cause life-threatening colitis
FINDINGSResearch led by scientists from UCLA and Harvard University has uncovered details about how the bacterium Clostridioides difficile causes excessive inflammation in the gut that can lead to potentially deadly colitis. Studying C. difficile toxin A, one of two toxins released by the bacterium, the researchers produced two key findings.They pinpointed which part of the toxic protein can permeate cell membranes to gain entry to cellular structures called endosomes, demonstrating that even fragments of the protein that contain that key segment are capable of accessing endosomes.In addition, they revealed how the toxin m...
Source: UCLA Newsroom: Health Sciences - January 8, 2021 Category: Universities & Medical Training Source Type: news

Is C diff Clostridium difficile Contagious
How Do You Get C. diff (Clostridium difficile)? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - December 10, 2020 Category: General Medicine Source Type: news