Scientists shed new light on infection process of gastrointestinal pathogen C. difficile
(VIB (the Flanders Institute for Biotechnology)) Scientists from the VIB-UGent Center for Inflammation Research identified the mechanisms by which the bacterial pathogen Clostridium difficile kills intestinal epithelial cells (IECs), thus destroying the protective mucosal barrier of the intestinal tract. The researchers demonstrate the physiological relevance of this process during infection and have published their findings in Nature Communications. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 21, 2018 Category: International Medicine & Public Health Source Type: news

Poo transplant: The ‘oil change’ treatment for your gut - when would you need it?
POO transplants could help to boost the health of the gut, and to avoid symptoms of bacterial infections, including C.difficile ’s nausea, dehydration, diarrhoea and weight loss. When would you need a faecal microbiota transplantation, and how could it boost your immune system? (Source: Daily Express - Health)
Source: Daily Express - Health - November 17, 2018 Category: Consumer Health News Source Type: news

November is C. diff Awareness Month. Mayo Clinic experts available for interviews
ROCHESTER, Minn. ??November is C. diff awareness month, a time to focus on raising awareness about the prevention and treatment of Clostridium Difficile Infections. Mayo Clinic experts are available for interviews. ?C. diff is a bacterial infection that causes symptoms ranging from diarrhea to life-threatening inflammation of the colon,? says Darrell Pardi, M.D., a gastroenterologist [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - November 1, 2018 Category: Research Source Type: news

Clostridium difficile associated disease
This review notes clinical manifestations usually occur on days 4 to 9 of antibiotic (AB) treatment, but may occur up to 8 weeks after discontinuation of ABs. Treatment is started with oral vancomycin or fidaxomicin. It is estimated 5-50% of treated patients have recurrence. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 31, 2018 Category: Consumer Health News Source Type: news

Cluster of factors could help predict C. diff
(Ohio State University) A cluster of factors may help predict which patients are likely to develop Clostridioides difficile, a potentially life-threatening disease commonly known as C. difficile or C. diff, a new study has found. And that could help in efforts to prevent infection, according to the researchers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 24, 2018 Category: International Medicine & Public Health Source Type: news

Think you're allergic to penicillin? Think again
People with penicillin allergies are more likely to get antibiotic-resistant infections such as C.difficile or MRSA, which can be life-threatening - yet 90 per cent are wrongly diagnosed. (Source: the Mail online | Health)
Source: the Mail online | Health - October 22, 2018 Category: Consumer Health News Source Type: news

Hospital Bed Sheets Still Germy Despite Washing
Despite being washed with industrial detergent in high, disinfecting temperatures, hospital sheets still were contaminated with the potentially life-threatening C. difficile bacteria, researchers found. And those sheets spread the bacteria to uncontaminated ones. (Source: WebMD Health)
Source: WebMD Health - October 19, 2018 Category: Consumer Health News Source Type: news

Hospital Bed Sheets Still Germy Despite Washing
FRIDAY, Oct. 19, 2018 -- Even after a thorough cleaning, traces of diarrhea-causing bacteria can remain on hospital bed sheets, researchers report. The new study suggests that linens could transmit Clostridium difficile infections between patients,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 19, 2018 Category: General Medicine Source Type: news

Clostridium difficile Spores Survive Laundering of Sheets
WEDNESDAY, Oct. 17, 2018 -- Clostridium difficile spores are able to survive laundering through a commercial washer extractor, according to a study published online Oct. 16 in Infection Control& Hospital Epidemiology. Joanna Tarrant, Ph.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 18, 2018 Category: Pharmaceuticals Source Type: news

C diff Spores on Bedsheets Survive Hospital Laundering C diff Spores on Bedsheets Survive Hospital Laundering
Typical laundering methods for hospital bedsheets left 60% of Clostridium difficile spores behind; their survival may contribute to future outbreaks, a study has found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 18, 2018 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Bacteria that cause diarrhoea survive the high temperatures used in hospital laundries
Researchers from De Montfort University found that C.difficile spores are present at levels sufficient to cause an outbreak even after sheets are washed as set out by the NHS' healthcare laundry policy. (Source: the Mail online | Health)
Source: the Mail online | Health - October 17, 2018 Category: Consumer Health News Source Type: news

Fulminant C. Diff Infection After Cardiac Surgery Fulminant C. Diff Infection After Cardiac Surgery
This paper outlines several independent risk factors for the development of a fulminant C. difficile infection after cardiac surgery.BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 17, 2018 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Infectious diarrhea spores survive high temperatures of hospital laundering
(Society for Healthcare Epidemiology of America) Washing contaminated hospital bedsheets in a commercial washing machine with industrial detergent at high disinfecting temperatures failed to remove all traces of Clostridium difficile (C. difficile), a bacteria that causes infectious diarrhea, suggesting that linens could be a source of infection among patients and even other hospitals, according to a study published today in Infection Control& Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 16, 2018 Category: International Medicine & Public Health Source Type: news

MRSA, MSSA and Gram-negative bacteraemia and Clostridium difficile infection: annual data for independent sector healthcare organisations
These statistics with accompanying commentary cover rates of MRSA, MSSA, E. coli, P. aeruginosa, Klebsiella spp. bacteraemia and CDI reported by independent sector organisations. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 3, 2018 Category: Consumer Health News Source Type: news

The risk of MRSA and C difficile in people with documented'penicillin allergy '
This Medicines Evidence Commentary discusses UK large population-based cohort study that found people with a documented'penicillin allergy'had increased risk of MRSA and C.diff, highlighting importance of ensuring only'true'penicillin allergies are documented, in line with NICE guideline on drug allergy. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 28, 2018 Category: Consumer Health News Source Type: news

Guidelines Recommend Fecal-Microbiota Transplant for Recurrent or Refractory C. Diff Guidelines Recommend Fecal-Microbiota Transplant for Recurrent or Refractory C. Diff
New joint guidelines from the British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) support the use of fecal-microbiota transplant (FMT) as second-line treatment for recurrent or refractory Clostridium difficile infection (CDI), but not for any other indications.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 21, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Leapfrog Group Report Shows Hospitals Failing to Eliminate Hospital-Acquired Infections; Medical Laboratories Can Help Providers ’ Antimicrobial Stewardship Programs
Contrary to CMS and Joint Commission programs implemented in 2017 to reduce them, incidents of hospital-acquired infections have risen for the past few years Clinical laboratories and anatomic pathologists know that hospital-acquired infections (HAIs) can be deadly, not just for patients, but for their caregivers and families as well. Even one HAI is too many. […] (Source: Dark Daily)
Source: Dark Daily - September 12, 2018 Category: Laboratory Medicine Authors: Jude Tags: Laboratory Management and Operations Laboratory News Laboratory Operations Laboratory Pathology Management & Operations anatomic pathology antimicrobial stewardship programs C. difficile Castlight Health catheter-associated urinary tract Source Type: news

Medical News Today: What allows C. difficile to survive so well in the gut?
Clostridium difficile causes infections that are hard to treat and that may have negative outcomes for health. What lends this bacterium its resilience? (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 12, 2018 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Folding poisons
(University of Freiburg) Researchers show how toxins of the bacterium Clostridium difficile get into cells in the gut. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 11, 2018 Category: International Medicine & Public Health Source Type: news

Clostridium difficile Infection: 5 Things to Know Clostridium difficile Infection: 5 Things to Know
As the most common microbial cause of healthcare-associated infections in US hospitals, clinicians need to have an understanding of C difficile infection. Start with these five key focus areas.Medscape Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 10, 2018 Category: Consumer Health News Tags: Gastroenterology Commentary Source Type: news

Guidance for preventing C. difficile in neonatal intensive care
(Society for Healthcare Epidemiology of America) Newborns require special diagnosis and treatment considerations for an infectious diarrhea known as Clostridioides difficile (C. difficile) infection, according to a new evidence-based white paper published today in Infection Control& Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America. The publication is in conjunction with the release of a companion review by the Centers for Disease Control and Prevention's Healthcare Infection Control Practices Advisory Committee (HICPAC). (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - August 30, 2018 Category: Infectious Diseases Source Type: news

Enteric Infections Common in IBD Flares Enteric Infections Common in IBD Flares
About one in six patients experiencing flares of inflammatory bowel disease (IBD) have non-Clostridium difficile enteric infections, according to a new study.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - August 27, 2018 Category: Pathology Tags: Gastroenterology News Source Type: news

Fecal Transplant for Severe Refractory C. Difficile Infection Fecal Transplant for Severe Refractory C. Difficile Infection
This RCT compared the efficacy of two fecal microbiota transplant protocols associated with vancomycin in curing patients with severe Clostridium difficile infection refractory to antibiotics.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 16, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Mother, 32, escapes death after she caught a potentially killer bug
Rosie Summers, from Surrey, unknowingly caught Clostridium difficile during a stay in hospital to combat a kidney infection. She spent a week in the same hospital fighting for her life against sepsis. (Source: the Mail online | Health)
Source: the Mail online | Health - August 15, 2018 Category: Consumer Health News Source Type: news

C. difficile Tied to Increased Graft Loss in Solid Organ Recipients
Proven infections, antibiotic treatments in past three months tied to increased development of CDI (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - August 13, 2018 Category: Respiratory Medicine Tags: Cardiology, Gastroenterology, Infections, Nephrology, Pulmonology, Surgery, Journal, Source Type: news

C. difficile Tied to Increased Graft Loss in Solid Organ Recipients
MONDAY, Aug. 13, 2018 -- For solid organ transplant (SOT) recipients, Clostridium difficile infection (CDI) is associated with increased graft loss, according to a study published in the July issue of the American Journal of Transplantation. Alexia... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 13, 2018 Category: Pharmaceuticals Source Type: news

It ’s Not Yet Clear How to Boost the Microbiome. But Diet Is the Best Bet
The gut microbiome—the billions of bacteria that live inside the human digestive tract—is the focus of some of today’s most exciting and compelling medical research. Studies have linked microbiome-related imbalances to health conditions ranging from depression and Parkinson’s disease to heart disease. Some researchers have even started referring to the microbiome as a “forgotten organ” because of the indispensable role it plays in human health. It’s fairly clear that the foods a person eats—or doesn’t eat—can affect the composition of his or her microbiome. Resear...
Source: TIME: Health - August 8, 2018 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized healthytime Research Source Type: news

C. diff Infection and Graft Loss in Solid Organ Transplants C. diff Infection and Graft Loss in Solid Organ Transplants
The development of C. difficile infection following solid organ transplantation may contribute to an increased risk of graft loss, a new study suggests.American Journal of Transplantation (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - August 7, 2018 Category: Surgery Tags: Transplantation Journal Article Source Type: news

Comparative efficacy of treatments for Clostridium difficile infection: a systematic review and network meta-analysis
This Systematic Review noted fidaxomicin provides sustained symptomatic cure most frequently and is better treatment than vancomycin except in those with severe infections, and could be considered 1stline therapy, whilst metronidazole should not be recommended (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 18, 2018 Category: Consumer Health News Source Type: news

The benefits of MCT oil
(Natural News) You may have heard of the many benefits of coconut oil, especially to your skin. But what you may not know is that coconut oil also has potent antibacterial properties, thanks to its medium-chain triglyceride (MCT) content. Clostridium difficile is a hardy bacteria known to survive even the onslaught of antibiotics. However, it... (Source: NaturalNews.com)
Source: NaturalNews.com - July 9, 2018 Category: Consumer Health News Source Type: news

Germ-blasting robot sets its sights on fighting C. difficile outbreaks
Germ-blasting robot Solaris Lytbot is a portable "no-touch" disinfection technology that uses pulsed UV light to eliminate pathogens, but experts are worried cash-strapped hospitals will use automated disinfection instead of humans to save money. (Source: CBC | Health)
Source: CBC | Health - July 8, 2018 Category: Consumer Health News Tags: News/Canada/Toronto Source Type: news

A full hospital does not necessarily mean higher infection risk
Most people probably figure the more people in a hospital, the more likely a patient is to get commonly-transferable illnesses, such as Clostridium difficile. (Source: Health News - UPI.com)
Source: Health News - UPI.com - July 2, 2018 Category: Consumer Health News Source Type: news

Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study
This research article covers a UK study (n=64,141 penicillin allergy [PA] and 237,258 matched comparators) noted documented penicillin allergy was linked to increased risk of MRSA (HR 1.69; 95% CI 1.51 to 1.90) and C difficile (1.26; 1.12 to 1.40) that was mediated by increased use of alternative (non- β lactam) antibiotics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 29, 2018 Category: Consumer Health News Source Type: news

Penicillin Allergy Linked to MRSA, C. Difficile Risk
THURSDAY, June 28, 2018 -- There is a correlation for documented penicillin allergy with increased risk of methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile, which is mediated by increased use of β-lactam alternative... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 28, 2018 Category: Pharmaceuticals Source Type: news

Patients with penicillin allergy at increased risk of ‘superbug’ infections
Patients who have a record of a penicillin allergy are at an increased risk of developing the drug resistant infection MRSA and healthcare-associated infection C difficile, according to researchers. (Source: Nursing Times)
Source: Nursing Times - June 28, 2018 Category: Nursing Source Type: news

Penicillin Allergy Linked to MRSA, C difficile Infections Penicillin Allergy Linked to MRSA, C difficile Infections
Patients with documented penicillin allergy have a greater risk of developing new methicillin-resistant Staphylococcus aureus and Clostridium difficile infections, a study has found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 27, 2018 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Patients believed allergic to penicillin have increased risks of MRSA and C. difficile
(Massachusetts General Hospital) Analysis of outpatient records of large number of British patients reveals that those believed to be allergic to penicillin have significantly increased risks of contracting the dangerous infections MRSA and C. difficile. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 27, 2018 Category: Infectious Diseases Source Type: news

'Remarkable drop' in C. difficile infections found at Canadian hospitals
Rates of C. difficile, the most common infectious cause of diarrhea in hospitalized patients in Canada, have decreased 36 per cent. Researchers say improvements in infection-control measures may have contributed to the decrease. (Source: CBC | Health)
Source: CBC | Health - June 25, 2018 Category: Consumer Health News Tags: News/Health Source Type: news

'Remarkable drop' in C. difficile infections at Canadian hospitals
Rates of C. difficile, the most common infectious cause of diarrhea in hospitalized patients in Canada, have decreased 36 per cent. Researchers say improvements in infection control measures may have contributed to the decrease. (Source: CBC | Health)
Source: CBC | Health - June 25, 2018 Category: Consumer Health News Tags: News/Health Source Type: news

Deep-sea sponges may stem the antibiotic-resistance crisis
Researchers from Florida Atlantic University found that out of 50 sponges, more than half contain so-called 'good bacteria' that fight off life-threatening infections such as C.difficile. (Source: the Mail online | Health)
Source: the Mail online | Health - June 25, 2018 Category: Consumer Health News Source Type: news

Clostridium difficile infections have decreased 36 percent in Canadian hospitals
(Canadian Medical Association Journal) Rates of C. difficile infections have decreased 36 percent in hospitals across Canada, although the virulent NAP1 strain associated with severe illness and deaths is the most common strain, according to research published in CMAJ (Canadian Medical Association Journal). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 25, 2018 Category: International Medicine & Public Health Source Type: news

Aimee Shen of Tufts Medical School granted PATH award from Burroughs Wellcome Fund
(Tufts University, Health Sciences Campus) Microbiologist Aimee Shen of Tufts University School of Medicine has received a prestigious 2018 Investigator in the Pathogenesis of Infectious Disease award from the Burroughs Wellcome Fund for her research on C. difficile. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 25, 2018 Category: Infectious Diseases Source Type: news

Fecal Transplant Promising Primary Therapy for C diff Fecal Transplant Promising Primary Therapy for C diff
Fecal microbiota transplantation can be used for the first-line treatment of C difficile, and it might also have an effect on neurologic and autoimmune diseases, such as autism and alopecia areata.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 19, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Deep-sea marine sponges may hold key to antibiotic drug resistance
(Florida Atlantic University) FAU's Harbor Branch houses more than 1,000 strains of actinobacteria, one of the most prolific microbial groups for the production of natural products. Derived from sea sponges and other macro-organisms, several strains were identified for their potent antifungal activity, for anti-MRSA activity, and for both antifungal and antibacterial activities. A key finding was the identification of a strain that produced metabolites that are more potent than the bacterial antibiotic, vancomycin, against C. difficile. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 19, 2018 Category: Infectious Diseases Source Type: news

Test can identify ICU patients at most risk of serious infections
A new test can identify intensive care patients at highest risk of potentially life-threatening secondary infections, including from antibiotic-resistant bacteria such as MRSA and C difficile, according to UK researchers. (Source: Nursing Times)
Source: Nursing Times - June 18, 2018 Category: Nursing Source Type: news

Test can identify patients in intensive care at risk of life-threatening infections
(University of Cambridge) Patients in intensive care units are at significant risk of potentially life-threatening secondary infections, including from antibiotic-resistant bacteria such as MRSA and C. difficile. Now, a new test could identify those at greatest risk -- and speed up the development of new therapies to help at-risk patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 13, 2018 Category: International Medicine & Public Health Source Type: news

Bezlotoxumab for prevention of recurrence of Clostridium difficile infection
This evidence review states that Bezlotoxumab is a monoclonal antibody that neutralises C. difficile toxin B, licensed for prevention of infection recurrence in those at high risk. The authors conclude that due to limitations of the evidence and the high cost of treatment, it is difficult to see a place in therapy for this agent. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 8, 2018 Category: Consumer Health News Source Type: news

Killing bacteria by silencing genes may be alternative to antibiotics
(Penn State) A new approach to killing C. difficile that silences key bacterial genes while sparing other bacteria may provide a new way to treat the most common hospital-acquired bacterial infection in the United States, according to researchers. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 6, 2018 Category: Infectious Diseases Source Type: news

Do You Have the Right Stuff to Be a Stool Donor?
Altruism, and a little financial incentive, can be motivating factors. (Source: NYT Health)
Source: NYT Health - June 5, 2018 Category: Consumer Health News Authors: RONI CARYN RABIN Tags: Transplants Feces Antibiotics Digestive Tract Clostridium Difficile (Bacterium) Infections Source Type: news

Clostridium difficile Patients on Opioids Fare Much Worse Clostridium difficile Patients on Opioids Fare Much Worse
The slowing of gut motility related to opioids might lead to more severe infection, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 3, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news