What Are Toxin-Mediated Diseases?
Discussion A poison is a generic term for “a substance with an inherent property that tends to destroy life or impair health.” A toxin is more specific and is “any poison produced by an organism, characterized by antigenicity in certain animals and high molecular weight, and including the bacterial toxins that are the causative agents of tetanus, diphtheria, etc., and such plant and animal toxins as ricin and snake venom.” A toxin does not include those substances that are made synthetically produced. Venom is also a toxin that is used by animals and insects for predation or defense which can cause ...
Source: PediatricEducation.org - April 12, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Healthcare-associated infections
Clostridioides difficile (C. difficile), methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) are bacterial infections that commonly occur as a direct result of healthcare interventions (such as medical or surgical treatment), or from being in contact with a healthcare setting. They are the most well-known healthcare-associated infections (HCAIs). HCAIs pose a serious risk to patients, staff and visitors, can incur high costs for the NHS, and can cause significant morbidity to those infected. The emergence of new infections also poses a risk to patients and staff, as highlighted by the transmis...
Source: Current Awareness Service for Health (CASH) - March 26, 2021 Category: Consumer Health News Source Type: news

Universal screening for Clostridioides difficile at an urban academic medical center, Infection Control & Hospital Epidemiology 42(3): 351-352
We implemented universal inpatient Clostridioides difficile screening at an 800-bed hospital. Over 3 years, 2,010 of 47,048 screening tests (4.2%) were positive, with significantly higher rates of C. difficile colonization on transplant units than medical-surgical units: 5.4% (152 of 2,801) versus 4.3% (880 of 20,564), respectively (P =.005). Compliance with screening ranged from 79% to 96%. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 17, 2021 Category: Consumer Health News Source Type: news

Antibiotic Prescribing Choices and Their Comparative C. Difficile Infection Risks: A Longitudinal Case-Cohort Study, Clinical Infectious Diseases 72(5): 836-844
Conclusions C. difficile infection risk increases with antibiotic duration, and there are wide disparities in risks associated with antibiotic courses used for similar indications. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 17, 2021 Category: Consumer Health News Source Type: news

Impact of a C. difficile infection (CDI) reduction bundle and its components on CDI diagnosis and prevention, American Journal of Infection Control 49(3): 319-326
A C. difficile Infection reduction bundle showed variable impact. • A 75% decrease in hospital-associated C. difficile infection post-implementation was observed for one of the hospitals • Processes and intermediate outcomes should be critically evaluated and deconstructed Published bundles to reduce Clostridioides difficile Infection (CDI) frequently lack inf ormation on compliance with individual elements. We piloted a computerized clinical decision support-based intervention bundle and conducted detailed evaluation of several intervention-related measures. A quasi-experimental study of a bundled intervention w...
Source: Current Awareness Service for Health (CASH) - March 17, 2021 Category: Consumer Health News Source Type: news

Peggy Lillis Foundation and Ferring Pharmaceuticals Partner to Support...
Peggy Lillis Foundation for C. diff Education & Advocacy (PLF), the leading patient organization combating C. difficile infections (CDI), partners with Ferring Pharmaceuticals through a new...(PRWeb March 11, 2021)Read the full story at https://www.prweb.com/releases/peggy_lillis_foundation_and_ferring_pharmaceuticals_partner_to_support_patients_with_c_difficile_infection/prweb17784316.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - March 11, 2021 Category: Pharmaceuticals Source Type: news

Common Antibiotics for Diverticulitis Have Higher C difficile Risks Common Antibiotics for Diverticulitis Have Higher C difficile Risks
Dr David Johnson comments on new data indicating that it may be time to move away from metronidazole plus a fluoroquinolone in certain patients.Medscape Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 25, 2021 Category: Consumer Health News Tags: Gastroenterology Commentary Source Type: news

Faecal microbiota transplant for recurrent or refractory Clostridioides difficile infection, Medtech innovation briefing [MIB247]
The main points from the evidence summarised in this briefing are from 6 studies (1 network meta-analysis, 4 systematic reviews and a prospective registry) including a total of 7,314 people with recurrent or refractory C. difficile infection. They show that FMT is more effective than commonly used antibiotics such as vancomycin and fidaxomicin in people with recurrent or refractory C. difficile infection. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news

Transmission Dynamics of Clostridioides difficile in 2 High-Acuity Hospital Units, Clinical Infectious Diseases 72: S1-S7
Conclusions Although prevalence was similar between the units, there were important differences in the rates of transmission and clearance. Influential factors may include antimicrobial exposure or other patient-care factors. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news

Shortcourse versus longcourse antibiotic treatment in patients with uncomplicated gramnegative bacteremia: A systematic review and metaanalysis, Journal of Clinical Pharmacy & Therapeutics 46(1): 173-180
What is known and objective: Gram ‐negative bacteremia remains a major health problem around the world. The optimal duration of antibiotic treatment has been poorly defined, and there are significant differences of opinion between clinicians. We conducted this systematic review and meta‐analysis to compare the clinical outcomes of short‐course and long‐course treatments in patients with uncomplicated gram‐negative bacteremia. Methods: We searched public databases (PubMed, EMBASE and Cochrane Library) to identify eligible studies. The primary outcomes were all‐cause mortality and the incidence of recurrent bacte...
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news

Toxic Clostridioides (formerly Clostridium) difficile colitis: No longer a diarrhea associated infection, American journal of surgery 221(1): 240-242
Conclusion: CDI must be suspected in patients who rapidly develop abdominal distention, vague abdominal complaints or change in bowel function even in the absence of diarrhea, especially if coupled with multi-system organ failure. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news

Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial, American journal of respiratory and critical care medicine 203(2): 202-210.
Rationale: Although early antimicrobial discontinuation guided by procalcitonin (PCT) has shown decreased antibiotic consumption in lower respiratory tract infections, the outcomes in long-term sepsis sequelae remain unclear. Objectives: To investigate if PCT guidance may reduce the incidence of long-term infection-associated adverse events in sepsis. Methods: In this multicenter trial, 266 patients with sepsis (by Sepsis-3 definitions) with lower respiratory tract infections, acute pyelonephritis, or primary bloodstream infection were randomized (1:1) to receive either PCT-guided discontinuation of antimicrobials or stand...
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news

Association between Antibiotic Consumption and Incidence of Clostridioides difficile Infection in a Hospital. Journal of Korean medical science 35(47): e407
Previous exposure to antimicrobials is a major risk factor for Clostridioides difficile infection (CDI). Antibiotic prescription and C. difficile toxin assay records of patients admitted to a tertiary hospital in Korea from 2009 to 2013 were collected to investigate the association between antibiotic consumption and CDI incidence. A Spearman's correlation analysis between CDI incidence (positive result of toxin assay/10,000 admissions) and antibiotic consumption (defined daily dose/1,000 patient-days) was performed on a monthly basis. Using the matched month approach, we found a significant correlation between CDI rate and...
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news

A syndrome-based approach to antimicrobial stewardship in an Arizona skilled nursing facilityMoving the needle through quality improvement. American journal of infection control 48(12): 1537-1539
In 2015, an intervention to reduce unnecessary antibiotic prescribing for suspect urinary tract infection (UTI) was implemented in an Arizona skilled nursing facility. • Intervention included use of a 48[HYPHEN]hour enhanced observation protocol instead of urine culturing in low infection likelihood scenarios (eg, confusion without localizing signs of infection) and monthly feedback to providers on culturing and prescribing patterns. • In the 2 years following implementation of the intervention, antibiotic prescribing for suspect UTIs decreased by 85%, and C. difficile incidence by 86%, with no associated uroseps...
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news

Using diagnostic stewardship to reduce rates, healthcare expenditures and accurately identify cases of hospital-onset Clostridioides difficile infection, Infection Control & Hospital Epidemiology 42(1): 51-56
Conclusions: Initiatives to decrease risk for CDI and diagnostic stewardship of C. difficile stool NAAT significantly reduced HO-HCFA CDI rates, detection of potential false-positives associated with laxative use, and lowered healt hcare costs. Diagnostic stewardship itself had the most dramatic impact on outcomes observed and served as an effective tool in reducing HO-HCFA CDI rates. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news

Clostridium difficile Infection Reservoirs Within an Acute Rehabilitation Environment, American Journal of Physical Medicine & Rehabilitation 100(1): 44-47
Conclusions: Nonsporicidal disinfectant was not effective on hospital floors. Sporicidal disinfection of the floor is important when rates of C difficile infection are increased. Wheelchairs are complex devices and difficult to properly clean. The hospital purchased an ultraviolent device for wheelchair cleaning with a subsequent reduction in spores on repeat cultures. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news

Cost Consequences for the NHS of Using a Two-Step Testing Method for the Detection of Clostridium difficile with a Point of Care, Polymerase Chain Reaction Test as the First Step
The two-step, POCT strategy was estimated to save £ 283,282 per 1000 hospitalized NHS patients with suspected infectious diarrhoea. Sensitivity analysis indicated that the turnaround time for the POCT was the largest driver for cost savings. Providing the POCT has sufficiently high diagnostic accuracy for detecting C. difficile, the two-step, POCT strategy for CDI identification is likely to be cost saving for NHS hospitals with an offsite laboratory. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 14, 2021 Category: Consumer Health News Source Type: news

An Analysis of Clostridium difficile Environmental Contamination During and After Treatment for C difficile Infection
There were significant reductions in C difficile recovery from both faeces and the environment around fidaxomicin versus vancomycin/metronidazole recipients. Therefore, fidaxomicin treatment may lower the C difficile transmission risk by reducing excretion and environmental contamination. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 14, 2021 Category: Consumer Health News Source Type: news

Study reveals new details about how bacterial toxins cause life-threatening colitis
FINDINGSResearch led by scientists from UCLA and Harvard University has uncovered details about how the bacterium Clostridioides difficile causes excessive inflammation in the gut that can lead to potentially deadly colitis. Studying C. difficile toxin A, one of two toxins released by the bacterium, the researchers produced two key findings.They pinpointed which part of the toxic protein can permeate cell membranes to gain entry to cellular structures called endosomes, demonstrating that even fragments of the protein that contain that key segment are capable of accessing endosomes.In addition, they revealed how the toxin m...
Source: UCLA Newsroom: Health Sciences - January 8, 2021 Category: Universities & Medical Training Source Type: news

Is C diff Clostridium difficile Contagious
How Do You Get C. diff (Clostridium difficile)? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - December 10, 2020 Category: General Medicine Source Type: news

UBCO researchers suggest stool transplants can battle serious infections
(University of British Columbia Okanagan campus) Could number two be number one when it comes to combating recurrent Clostridium difficile (CDI) infections? Using genetic material analysis and machine learning, UBC researchers have pinpointed several key factors to ensure successful fecal microbiota transplants (FMT), which have proven successful in treating bacterial infections in the gut including illnesses like C. difficile, Crohn's Disease, Colitis and even obesity, explains lead author Negin Kazemian. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 9, 2020 Category: International Medicine & Public Health Source Type: news

Comparing intervention strategies for reducing Clostridioides difficile transmission in acute healthcare settings: an agent-based modeling study
Conclusions: Overall, interventions that decrease patient susceptibility to colonization by C. difficile, such as antibiotic stewardship, were the most effective interventions in reducing both colonizations and CDI cases. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 18, 2020 Category: Consumer Health News Source Type: news

In your gut: How bacteria survive low oxygen environments
(Instituto de Tecnologia Qu í mica e Biol ó gica Ant ó nio Xavier da Universidade NOVA de Lisboa - ITQB NOV) Researchers from ITQB NOVA, in collaboration with the Institut Pasteur in Paris, have shed light on the mechanisms that allow Clostridioides difficile, a pathogen that can only grow in oxygen-free environments, to survive low oxygen levels. C. difficile is a major cause of intestinal problems associated with the use of antibiotics, causing an estimated number of 124k cases per year in the EU, costing on average 5k € per patient, as a direct consequence of healthcare-associated contagion. (Sourc...
Source: EurekAlert! - Infectious and Emerging Diseases - November 2, 2020 Category: Infectious Diseases Source Type: news

Fecal Transplant Linked to Reduced C Difficile Mortality Fecal Transplant Linked to Reduced C Difficile Mortality
Vancomycin followed by fecal microbiota transplant was associated with reduced Clostridioides difficile (C diff)-related mortality in patients hospitalized with refractory severe or fulminant C diff.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - October 15, 2020 Category: Gastroenterology Tags: Gastroenterology News Source Type: news

C. difficile Linked to Surgery Risk in Pediatric Crohn's C. difficile Linked to Surgery Risk in Pediatric Crohn's
In pediatric Crohn's disease, a Clostridioides difficile infection detected within the first year after diagnosis is associated with a shorter time to first bowel resection surgery.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - October 15, 2020 Category: Gastroenterology Tags: Pediatrics News Source Type: news

Fecal Transplant Safe, Effective for C. Difficile Through Six Months
TUESDAY, Oct. 6, 2020 -- Fecal microbiota transplantation (FMT) is effective for Clostridium difficile infection (CDI) through six months and has a good safety profile, according to a study published online Oct. 1 in Gastroenterology. Colleen R.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 6, 2020 Category: Pharmaceuticals Source Type: news

Real-World Safety, Efficacy Found for Fecal Transplants Real-World Safety, Efficacy Found for Fecal Transplants
Ninety percent of patients treated with fecal microbiota transplantation recovered from C. difficile infections, with few serious adverse events, a study of registry data found.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - October 2, 2020 Category: Gastroenterology Tags: Gastroenterology News Source Type: news

Reductions in Methicillin-resistant Staphylococcus aureus, Clostridium difficile Infection and Intensive Care Unit-Acquired Bloodstream Infection Across the United Kingdom Following Implementation of a National Infection Control Campaign
Methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile infections declined across the UK National Health Service in the decade that followed implementation of an infection control campaign. The national impact on intensive care unit (ICU)-acquired infections has not been documented. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 23, 2020 Category: Consumer Health News Source Type: news

Lumen Bioscience names chief medical officer after $16M Series B
Seattle-based Lumen Bioscience hired a chief medical officer from outside the Puget Sound region after recording a $16 million Series B earlier this month. The biotech announced last week that it’s brought on Mike Spirgarelli, who will be leading the company’s clinical development operations. To date, Lumen has raised $68 million between equity and non-dilutive investments to support its three clinical programs for C. difficile, norovirus and t raveler’s diarrhea. Lumen’s lead candidate… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - September 16, 2020 Category: Biotechnology Authors: Megan Campbell Source Type: news

Lumen Bioscience names chief medical officer after $16M Series B
Seattle-based Lumen Bioscience hired a chief medical officer from outside the Puget Sound region after recording a $16 million Series B earlier this month. The biotech announced last week that it’s brought on Mike Spirgarelli, who will be leading the company’s clinical development operations. To date, Lumen has raised $68 million between equity and non-dilutive investments to support its three clinical programs for C. difficile, norovirus and t raveler’s diarrhea. Lumen’s lead candidate… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - September 16, 2020 Category: Pharmaceuticals Authors: Megan Campbell Source Type: news

Clostridium Difficile Colitis (C. diff, C. difficle Colitis)
Title: Clostridium Difficile Colitis (C. diff, C. difficle Colitis)Category: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 9/3/2020 12:00:00 AM (Source: MedicineNet Digestion General)
Source: MedicineNet Digestion General - September 3, 2020 Category: Nutrition Source Type: news

German Scientists Train Dogs to Detect the Presence of COVID-19 in Saliva Samples; Can a Canine ’s Nose Be as Accurate as Clinical Laboratory Testing?
Though only in the pilot study phase, results correlate with earlier studies where both dogs and humans were able to “smell” specific diseases in people Man’s best friend has risked life and limb to save humans for centuries. Now, researchers in Germany have discovered that pooches may be useful in the fight against COVID-19 as […] The post German Scientists Train Dogs to Detect the Presence of COVID-19 in Saliva Samples; Can a Canine’s Nose Be as Accurate as Clinical Laboratory Testing? first appeared on Dark Daily. (Source: Dark Daily)
Source: Dark Daily - August 28, 2020 Category: Laboratory Medicine Authors: Jude Tags: Laboratory Pathology AKC American Kennel Club anatomic pathology Bundeswehr C. diff clinical laboratory clinical pathology Clostridium difficile COVID-19 Dark Daily dark intelligence group Dark Report Hannover Medical School Ho Source Type: news

Early Colectomy for Toxic Megacolon in C. difficile Infection Early Colectomy for Toxic Megacolon in C. difficile Infection
Can early colectomy in patients who have toxic megacolon due to Clostridium difficile colitis improve outcomes and reduce mortality?Southern Medical Journal (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - August 4, 2020 Category: Surgery Tags: General Surgery Journal Article Source Type: news

Insights on the gut microbiome could shape more powerful, precise treatment
(Brigham and Women's Hospital) In a recently published study, investigators from Brigham and Women's Hospital explore how the dynamics of bacterial species may influence the success of fecal microbiota transplantation in treating recurrent C. difficile infection. In Nature Communications, the team presents an algorithm to design personalized probiotic cocktails for patients with unhealthy gut microbiomes due to rCDI. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 31, 2020 Category: International Medicine & Public Health Source Type: news

Popular Heartburn Drugs Linked to Heightened COVID-19 Risk
A popular form of heartburn medication may increase a person’s risk of developing COVID-19, according to a new study, lengthening the already long list of risk factors for the virus. In the study, published Tuesday in pre-print form in the American Journal of Gastroenterology, scientists led by Cedars-Sinai Medical Center’s Dr. Brennan Spiegel conducted an online survey involving more than 86,000 people. Among them, more than 53,000 reported abdominal pain or discomfort, acid reflux, heartburn or regurgitation, and answered questions about the medications they took to relieve those symptoms. Of those, more than...
Source: TIME: Health - July 7, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

C. diff. Infections Double Death Risk
Hospitalized patients infected with the dangerous diarrhea bug Clostridium difficile (C. diff.) face more than twice the risk of dying than hospitalized patients without the infection, a Dutch study shows. (Source: WebMD Health)
Source: WebMD Health - June 19, 2020 Category: Consumer Health News Source Type: news

Bacterial and fungal etiology of sepsis in children in the United States: Reconsidering empiric therapy
Conclusion(s): In this nationally representative administrative database, the most common identified pathogen was S. aureus in previously healthy and chronically ill children. In addition, a high proportion of children with sepsis and select chronic diseases had infections with methicillin-resistant S. aureus, fungal infections, Pseudomonas infections, and C. difficile. Clinicians caring for pediatric patients should consider coverage of these organisms when administering empiric antimicrobials for sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news

Burden of Clostridioides difficile Infection Down in the U.S.
THURSDAY, April 2, 2020 -- From 2011 to 2017, there was a decrease in the estimated national burden of Clostridium difficile infection, according to a study published in the April 2 issue of the New England Journal of Medicine. Alice Y. Guh, M.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 2, 2020 Category: Pharmaceuticals Source Type: news

CDC Ranks Two More Drug-Resistant Microbes as ‘Urgent Threat’ to Americans; Clinical Laboratories Are Advised to Increase Awareness of Antimicrobial Resistance
In a separate study, HHS finds a 40% increase in sepsis cases, as more patients succumb to infections without effective antibiotics and antimicrobial drugs Given the drastic steps being taken to slow the spread of the Coronavirus in America, it’s easy to forget that significant numbers of patients die each year due to antibiotic-resistant bacteria […] (Source: Dark Daily)
Source: Dark Daily - March 20, 2020 Category: Laboratory Medicine Authors: Jude Tags: Laboratory Management and Operations Laboratory News Laboratory Operations Laboratory Pathology Laboratory Testing Management & Operations News From Dark Daily anatomic pathology antibiotic resistance c. auris C. difficile Candida au Source Type: news

Faecal transplants successful for C.Difficile, study shows
Results come from England ’s first licenced stool bank (Source: OnMedica Latest News)
Source: OnMedica Latest News - March 15, 2020 Category: UK Health Source Type: news

Clostridioides difficile infection flourishes with a high-protein, high-fat diet
(American Society for Microbiology) Mice fed a high-fat, high-protein diet were more likely to develop and die from antibiotic-driven Clostridioides difficile infections than mice fed a standard diet. In the same study, published in the journal mSystems, a high-carbohydrate diet was protective against severe C. difficile infection--but the researchers suspect that such a diet could produce healthy, asymptomatic carriers that can spread the pathogen. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 11, 2020 Category: International Medicine & Public Health Source Type: news

The Coronavirus Outbreak Should Bring Out the Best in Humanity
Pandemics are perversely democratic. They’re nasty, lethal and sneaky, but they don’t discriminate. No matter your age, ethnicity, religion, gender, or nation, you’re a part of the pathogenic constituency. That shared vulnerability, and the resulting human collectivism—a universal response to a universal threat—is newly and vividly evident in the face of the now-global outbreak of the novel coronavirus known as 2019-nCoV. As of writing, there have been over 30,000 diagnosed cases and over 630 related deaths. A virus that emerged in a single city, Wuhan, China—indeed, in a single crowded ...
Source: TIME: Health - February 8, 2020 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized 2019-nCoV Infectious Disease Source Type: news

Fly model offers new approach to unraveling 'difficult' pathogen
(University of California - San Diego) Clostridium difficile, a bacterium known to cause symptoms from diarrhea to life-threatening colon damage, is part of a growing epidemic for the elderly and hospitalized patients. Biologists have now developed models of the common fruit fly to help develop novel therapies to fight the pathogen. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 7, 2020 Category: Infectious Diseases Source Type: news

FDA OKs Fidaxomicin for C difficile in Children FDA OKs Fidaxomicin for C difficile in Children
The macrolide antibacterial is now approved in oral suspension and tablets for treatment of Clostridioides difficile-associated diarrhea (CDAD) in children aged 6 months and older.FDA Approvals (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - January 27, 2020 Category: Intensive Care Tags: Gastroenterology News Alert Source Type: news

Researchers identify key structure of C. difficle bacteria that could lead to future treatments
(University of Maryland School of Medicine) Researchers from the University of Maryland School of Medicine and their colleagues have identified the structure of the most lethal toxin produced by certain strains of Clostridium difficile bacteria, a potentially deadly infection associated with the use of antibiotics. The researchers mapped out the delivery and binding components of the toxin, which could pave the way for new drugs to neutralize it. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 2, 2020 Category: Infectious Diseases Source Type: news

Researchers identify starting point for designing drugs that cure clostridium difficile
(Advanced Science Research Center, GC/CUNY) A newly published paper in PNAS details a research breakthrough that provides a promising starting point for scientists to create drugs that can cure C. diff -- a virulent health care-associated infection that causes severe diarrhea, nausea, internal bleeding, and potentially death. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 2, 2020 Category: Biology Source Type: news

Fecal Microbiota Transplant in Severe C. difficile Infection Fecal Microbiota Transplant in Severe C. difficile Infection
Fecal microbiota transplant has been shown to be very effective in treating recurrent or refractory C. difficile infection. Is it beneficial in severe and fulminant C. difficile infection as well?Alimentary Pharmacology & Therapeutics (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - December 18, 2019 Category: Intensive Care Tags: Gastroenterology Journal Article Source Type: news

New discovery in C. difficile biology could lead to treatments for dangerous infections
(The Mount Sinai Hospital / Mount Sinai School of Medicine) A process called sporulation that helps the dangerous bacterium Clostridium difficile (C. difficile) to survive inhospitable conditions and spread is regulated by epigenetics, factors that affect gene expression beyond the DNA genetic code, researchers at the Icahn School of Medicine at Mount Sinai report. This is the first discovery that epigenetics regulate sporulation in any bacteria. Their research, published November 25th in Nature Microbiology, opens a new window to developing treatments for this devestating infection. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 25, 2019 Category: Infectious Diseases Source Type: news

WHO (World Health Organization) Antibacterial Preclinical Pipeline Review
Source: World Health Organization (WHO). Published: 11/2019. This web page provides information, data visualization, and results from the World Health Organization (WHO)'s review of preclinical antibacterial products in the pipeline worldwide. It captures data on 252 antibacterial agents in development, targeting the pathogens on the WHO priority pathogens list, Mycobacterium tuberculosis, and Clostridium difficile. (Text) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - November 1, 2019 Category: International Medicine & Public Health Source Type: news

Antibacterial Products in Clinical Development for Priority Pathogens 2019
Source: World Health Organization (WHO). Published: 11/2019. This web page provides information and data results from the World Health Organization (WHO) analysis of the pipeline of antibacterial products (antibiotics and biologicals) that were in phase I-III of clinical development (as of September 2019) and which had not, at that date, received market authorization for human use anywhere in the world. The analysis matched the products in development against the WHO priority pathogens list (PPL), Mycobacterium tuberculosis, and Clostridium difficile. (Text) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - November 1, 2019 Category: International Medicine & Public Health Source Type: news