Deep-sea marine sponges may hold key to antibiotic drug resistance
(Florida Atlantic University) FAU's Harbor Branch houses more than 1,000 strains of actinobacteria, one of the most prolific microbial groups for the production of natural products. Derived from sea sponges and other macro-organisms, several strains were identified for their potent antifungal activity, for anti-MRSA activity, and for both antifungal and antibacterial activities. A key finding was the identification of a strain that produced metabolites that are more potent than the bacterial antibiotic, vancomycin, against C. difficile. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 19, 2018 Category: Infectious Diseases Source Type: news

Test can identify ICU patients at most risk of serious infections
A new test can identify intensive care patients at highest risk of potentially life-threatening secondary infections, including from antibiotic-resistant bacteria such as MRSA and C difficile, according to UK researchers. (Source: Nursing Times)
Source: Nursing Times - June 18, 2018 Category: Nursing Source Type: news

Test can identify patients in intensive care at risk of life-threatening infections
(University of Cambridge) Patients in intensive care units are at significant risk of potentially life-threatening secondary infections, including from antibiotic-resistant bacteria such as MRSA and C. difficile. Now, a new test could identify those at greatest risk -- and speed up the development of new therapies to help at-risk patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 13, 2018 Category: International Medicine & Public Health Source Type: news

Bezlotoxumab for prevention of recurrence of Clostridium difficile infection
This evidence review states that Bezlotoxumab is a monoclonal antibody that neutralises C. difficile toxin B, licensed for prevention of infection recurrence in those at high risk. The authors conclude that due to limitations of the evidence and the high cost of treatment, it is difficult to see a place in therapy for this agent. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 8, 2018 Category: Consumer Health News Source Type: news

Killing bacteria by silencing genes may be alternative to antibiotics
(Penn State) A new approach to killing C. difficile that silences key bacterial genes while sparing other bacteria may provide a new way to treat the most common hospital-acquired bacterial infection in the United States, according to researchers. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 6, 2018 Category: Infectious Diseases Source Type: news

Do You Have the Right Stuff to Be a Stool Donor?
Altruism, and a little financial incentive, can be motivating factors. (Source: NYT Health)
Source: NYT Health - June 5, 2018 Category: Consumer Health News Authors: RONI CARYN RABIN Tags: Transplants Feces Antibiotics Digestive Tract Clostridium Difficile (Bacterium) Infections Source Type: news

Clostridium difficile Patients on Opioids Fare Much Worse Clostridium difficile Patients on Opioids Fare Much Worse
The slowing of gut motility related to opioids might lead to more severe infection, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 3, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Antibiotics Weren ’ t Used to Cure These Patients. Fecal Bacteria Were.
In a small study, doctors used so-called fecal transplants to treat a serious gut infection in patients. The transplants, from healthy donors, were as effective as antibiotics. (Source: NYT Health)
Source: NYT Health - June 2, 2018 Category: Consumer Health News Authors: GINA KOLATA Tags: Feces Antibiotics Transplants Digestive Tract Bacteria Clostridium Difficile (Bacterium) Clinical Trials Infections Colitis New England Journal of Medicine University of Oslo Source Type: news

The Latest Poop On Fecal Transplants Vs. Antibiotics For C. Difficile Diarrhea
How can more poop actually help with severe diarrhea? Well, when the diarrhea is caused by the antibiotic-resistant bacteria Clostridium difficile, a poop transplant may help get to the bottom of the problem. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - June 2, 2018 Category: Pharmaceuticals Authors: Bruce Y. Lee, Contributor Source Type: news

Fecal Transplants vs. Antibiotics. The Test.
Instead of waiting until antibiotics have failed before trying fecal transplants, researchers tried giving the fecal bacteria first. (Source: NYT Health)
Source: NYT Health - June 2, 2018 Category: Consumer Health News Authors: GINA KOLATA Tags: Feces Antibiotics Transplants Digestive Tract Bacteria Clostridium Difficile (Bacterium) Clinical Trials Infections Colitis New England Journal of Medicine University of Oslo Source Type: news

Antibiotics Didn ’ t Cure Their Infections. Fecal Bacteria Did.
In a small study, fecal transplants ended a persistent, dangerous gut infection just as effectively as drugs. (Source: NYT Health)
Source: NYT Health - June 2, 2018 Category: Consumer Health News Authors: GINA KOLATA Tags: Feces Antibiotics Transplants Digestive Tract Bacteria Clostridium Difficile (Bacterium) Clinical Trials Infections Colitis New England Journal of Medicine University of Oslo Source Type: news

UCI-Harvard research may help combat the deadly gastrointestinal infection C. diff
(University of California - Irvine) Clostridium difficile   infection is the most common cause of antibiotic-associated diarrhea in developed countries. Researchers have discovered how the C. diff toxin B recognizes the human Frizzled protein, the receptor it uses to invade intestinal cells and lead to deadly gastrointestinal infections. The findings, published in Science, could pave the way for new C. diff antitoxins and also show potential for the development of novel anti-cancer drugs. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 11, 2018 Category: International Medicine & Public Health Source Type: news

Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B
Clostridium difficile infection is the most common cause of antibiotic-associated diarrhea in developed countries. The major virulence factor, C. difficile toxin B (TcdB), targets colonic epithelia by binding to the frizzled (FZD) family of Wnt receptors, but how TcdB recognizes FZDs is unclear. Here, we present the crystal structure of a TcdB fragment in complex with the cysteine-rich domain of human FZD2 at 2.5-angstrom resolution, which reveals an endogenous FZD-bound fatty acid acting as a co-receptor for TcdB binding. This lipid occupies the binding site for Wnt-adducted palmitoleic acid in FZDs. TcdB binding locks th...
Source: ScienceNOW - May 10, 2018 Category: Science Authors: Chen, P., Tao, L., Wang, T., Zhang, J., He, A., Lam, K.-h., Liu, Z., He, X., Perry, K., Dong, M., Jin, R. Tags: Biochemistry, Microbiology reports Source Type: news

Probiotics can prevent bacterial diarrhoea in hospital patients receiving antibiotics
This NIHR Signal gives commentary on an updated Cochrane Review. It provides new evidence suggesting probiotics may be beneficial for hospitalised patients at risk of C. Difficile infection. Probiotics may be suitable for use in high-risk patients needing antibiotics, for example, older adults with underlying illness. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 9, 2018 Category: Consumer Health News Source Type: news

Probiotics Effective for Primary Prevention of C. Diff Probiotics Effective for Primary Prevention of C. Diff
Probiotics are effective for preventing Clostridium difficile infection (CDI) in patients treated with antibiotics, according to findings from two research groups.Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 7, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

New Help for Managing Clostridium difficile Infection New Help for Managing Clostridium difficile Infection
New guidelines from IDSA/SHEA highlight best practices for treatingC difficile infection. Dr David Johnson provides insight for all providers who must be cognizant of this widespread problem.Medscape Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 26, 2018 Category: Consumer Health News Tags: Gastroenterology Commentary Source Type: news

Probiotics useful in the fight against infection prevention
(Society for Healthcare Epidemiology of America) Probiotics may be a relatively safe, simple, and low-cost solution for preventing Clostridium difficile infections (CDI) in hospital settings, according to two studies published today in Infection Control& Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America. Both studies show that treating patients who received antibiotics with multi-strain probiotics, cut down on CDI incidence rates over time. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 26, 2018 Category: Infectious Diseases Source Type: news

Artificial Differences in C difficile Infection Rates Artificial Differences in C difficile Infection Rates
This report looks at how testing methods and frequency may have impacted the reported rates of C difficile infection.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 19, 2018 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

C. Difficile Risk Higher With Stoma Reversal Versus Colectomy
WEDNESDAY, April 18, 2018 -- Patients who undergo elective stoma reversal have a higher incidence of postoperative Clostridium difficile infection versus patients who undergo elective colectomy, according to a study published in the May issue of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 18, 2018 Category: Pharmaceuticals Source Type: news

Study finds NYC mice may be hotbeds of antibiotic-resistant bacteria
Apartment-dwelling rodents all over the city carry treatment-resistant C. difficile, E. coli, Shigella and Salmonella that can be transmitted to residents, the team found. (Source: the Mail online | Health)
Source: the Mail online | Health - April 17, 2018 Category: Consumer Health News Source Type: news

Study finds NYC mice are hotbeds of antibiotic-resistant bacteria
Apartment-dwelling rodents all over the city carry treatment-resistant C. difficile, E. coli, Shigella and Salmonella that can be transmitted to residents, the team found. (Source: the Mail online | Health)
Source: the Mail online | Health - April 17, 2018 Category: Consumer Health News Source Type: news

NYC Mice Are Carrying Antibiotic-Resistant Germs
People who live in cities are used to the company of furry vermin. But a new study reveals that mice and men may be sharing much more than just living quarters. In a study published in the journal mBio, researchers led by Dr. Ian Lipkin, professor of epidemiology at the Mailman School of Public Health at Columbia University, studied the gut microbes of 416 mice collected from mostly residential buildings all over New York City. Lipkin and his team did a thorough genetic analysis of the microbes they extracted from the feces of the mice, and found that they contained a number of disease-causing bacteria. Nearly 40% of the ...
Source: TIME: Health - April 17, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Bacteria healthytime Source Type: news

Clostridium difficile Infection: Prevention and Treatment Clostridium difficile Infection: Prevention and Treatment
This review provides evidence-based pointers on the prevention and treatment of C. difficile infection. What are the options, and how effective are they?American Family Physician (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 5, 2018 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

Researchers define target and mechanism of antibacterial drug fidaxomicin (dificid)
(Rutgers University) A team of Rutgers University and international scientists has determined the molecular target and mechanism of the antibacterial drug fidaxomicin (trade name Dificid). Fidaxomicin was approved in 2011 for treatment of the CDC 'urgent threat' bacterial pathogen Clostridium difficile (C. diff) and currently is one of two front-line drugs for treatment of C. diff. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 29, 2018 Category: Infectious Diseases Source Type: news

Medication Exposure and Risk of Recurrent C. diff Infection Medication Exposure and Risk of Recurrent C. diff Infection
How does exposure to medications such as antibiotics, corticosteroids, and acid-reducers impact the risk of recurrent C. difficile infection? Does risk differ according to living environment?Journal of the American Geriatrics Society (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 28, 2018 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

A moveable feast: Antibiotics give C. diff a nutrient-rich environment, no competition
(North Carolina State University) Using a mouse model, researchers from North Carolina State University have found that antibiotic use creates a " banquet " for Clostridium difficile (C. diff), by altering the native gut bacteria that would normally compete with C. diff for nutrients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2018 Category: International Medicine & Public Health Source Type: news

Machine learning model provides rapid prediction of C. difficile infection risk
(Massachusetts General Hospital) Investigators from Massachusetts General Hospital, the University of Michigan and Massachusetts Institute of Technology have developed investigational 'machine learning' models, specifically tailored to individual institutions, that can predict a patient's risk of developing C. difficile much earlier than it would be diagnosed with current methods. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 26, 2018 Category: Infectious Diseases Source Type: news

Metabolite therapy proves effective in treating C. difficile in mice
FINDINGSA team of UCLA researchers found that a metabolite therapy was effective in mice for treating a serious infection of the colon known as Clostridium difficile infection, or C. difficile.  Mice that were infected with C. difficile were treated with an experimental drug called CSA13, which increased levels of four protective metabolites — molecules that help fuel, maintain and mediate cells. Compared with mice that did not receive CSA13, the mice treated with the drug were significantly more likely to survive the infection, had lower rates of weight loss and — after the treatment was stopped — w...
Source: UCLA Newsroom: Health Sciences - March 20, 2018 Category: Universities & Medical Training Source Type: news

Evaluation of the US Food and Drug Administration sentinel analysis tools in confirming previously observed drug-outcome associations: the case of clindamycin and Clostridium difficile infection - Carnahan RM, Kuntz JL, Wang SV, Fuller C, Gagne JJ, Leonard CE, Hennessy S, Meyer T, Archdeacon P, Chen CY, Panozzo CA, Toh S, Katcoff H, Woodworth T, Iyer A, Axtman S, Chrischilles EA.
PURPOSE: The Food and Drug Administration's Sentinel System developed parameterized, reusable analytic programs for evaluation of medical product safety. Research on outpatient antibiotic exposures, and Clostridium difficile infection (CDI) with non-user r... (Source: SafetyLit)
Source: SafetyLit - March 19, 2018 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news

Two Simple Ways to Improve Diagnosis of Infectious Diseases Two Simple Ways to Improve Diagnosis of Infectious Diseases
Recent data support taking a hard look at clinical practices surrounding diagnostic testing in C difficile and bloodstream infections.Society for Healthcare Epidemiology of America (SHEA) (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - March 15, 2018 Category: Infectious Diseases Tags: Infectious Diseases Viewpoint Source Type: news

Long-term Effects of Fecal Transplant in Recurrent C. Diff Long-term Effects of Fecal Transplant in Recurrent C. Diff
Treatment of recurrent C. difficile infection with fecal microbiota transplantation has been shown to be safe in the short term, but might there be long-term adverse effects?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 13, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Clostridium difficile infection objectives
These objectives updated each financial year aim to help acute trusts and clinical commissioning groups to make continuous improvement in Clostridium difficile infection care. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 9, 2018 Category: Consumer Health News Source Type: news

AAAAI: Penicillin Allergy Label Linked to MRSA, C. difficile
(MedPage Today) -- Increase attributable to use of alternative antibiotics (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - March 5, 2018 Category: Infectious Diseases Source Type: news

New C difficile Guidelines Refine Diagnosis, Add FMT New C difficile Guidelines Refine Diagnosis, Add FMT
New guidelines for managing Clostridium difficile infection refine diagnosis, switch antibiotics for adults, include children, and add fecal microbiota transplantation.Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - February 16, 2018 Category: Pathology Tags: Infectious Diseases News Source Type: news

FDA OKs First Vancomycin Oral Solution for C diff Diarrhea FDA OKs First Vancomycin Oral Solution for C diff Diarrhea
Vancomycin hydrochloride for oral solution (Firvanq) is for treatment of Clostridium difficile-associated diarrhea and enterocolitis caused by Staphylococcus aureus, including methicillin-resistant strains.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 30, 2018 Category: Consumer Health News Tags: Infectious Diseases News Alert Source Type: news

CutisPharma Announces FDA Approval of Firvanq (vancomycin) for Treatment of Clostridium Difficile Associated Diarrhea and Staphylococcus Aureus Colitis
WILMINGTON, Mass. (Jan. 29, 2018) – CutisPharma announced today that the US Food and Drug Administration (FDA) has approved Firvanq (vancomycin hydrochloride) for oral solution, for the treatment of Clostridium difficile associated diarrhea and... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - January 29, 2018 Category: Drugs & Pharmacology Source Type: news

Sugary Shakes in the Hospital Aren ’ t Good Medicine
Food has the potential to be some of the best medicine. But not the kind of sugar-laden drinks ubiquitous in hospitals. (Source: NYT Health)
Source: NYT Health - January 25, 2018 Category: Consumer Health News Authors: DAVE LIEBERMAN, M.D. Tags: Hospitals Yogurt Diet and Nutrition Calories Food Health Insurance and Managed Care Malnutrition Cooking and Cookbooks Elderly Clostridium Difficile (Bacterium) Source Type: news

SHEA Updates Contact Precautions Recs for Drug-Resistant Bacteria SHEA Updates Contact Precautions Recs for Drug-Resistant Bacteria
The Society for Healthcare Epidemiology of America addresses when hospitals can safely stop protocols in the wake of multidrug-resistant infections and Clostridium difficile infections.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 12, 2018 Category: Consumer Health News Tags: Internal Medicine News Source Type: news

Guidelines Issued on Contact Precautions for MRSA, C. difficile
The Society for Healthcare Epidemiology of America has issued guidelines on how long contact precautions in acute-care hospitals should persist for numerous drug-resistant... (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - January 12, 2018 Category: Primary Care Source Type: news

Extended-pulsed Fidaxomicin Bests Vancomycin for C Diff in Older People Extended-pulsed Fidaxomicin Bests Vancomycin for C Diff in Older People
Extended-pulsed fidaxomicin, delivering 20 doses over a longer time period after initial daily dosing, appears superior to standard-dose vancomycin for sustained cure of Clostridium difficile infection in patients age 60 or older, according to results from an open-label randomized trial.Reuters Health Information (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - January 8, 2018 Category: Infectious Diseases Tags: Gastroenterology News Source Type: news

New treatment launched to reduce C. difficile recurrence
A new therapy for the prevention of recurrence of Clostridium difficile infection has been launched in the UK. (Source: Nursing Times)
Source: Nursing Times - January 8, 2018 Category: Nursing Source Type: news

Sugar alternative is NOT so healthy after all: Trehalose, a substitute used in many processed foods, is giving rise to a superbug, severe disease, study warns
(Natural News) A sugar alternative that was deemed “healthy” appears to be not so healthy after all. A new study discovered that the artificial sugar additive known as trehalose, which is found in many food products, potentially played a role in the increase of a deadly superbug called Clostridium difficile, which is a bacterium that causes infection,... (Source: NaturalNews.com)
Source: NaturalNews.com - January 6, 2018 Category: Consumer Health News Source Type: news

Updated meta-analysis of controlled observational studies: proton-pump inhibitors and risk of Clostridium difficile infection
This meta-analysis concludes that despite substantial statistical and clinical heterogeneity, the findings indicate a significant associated risk of incident CDI among PPI users, especially in general ward patients. The authors state that establishing a guideline for the use of PPI may help in the future with the control of CDI. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 4, 2018 Category: Consumer Health News Source Type: news

Unintended Consequences: Steps to Fight Sepsis Increase C. diff: Uptick in antibiotic use sets up C. diff infections.
This article reports on the effort of Mount Sinai Hospital in New York City to identify potential sepsis cases and conduct antibiotic treatment that led to an increase in 12 Clostridium difficile infections. Topics mentioned include a national initiative to rein in antibiotic use and overuse, increase in antibiotic use after implementation of a sepsis care bundle, and an increase in risk for C. diff due to broad spectrum antibiotics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 4, 2018 Category: Consumer Health News Source Type: news

Medical News Today: Food additive to blame for C. difficile epidemic
Clostridium difficile infections are on the rise, and they now routinely kill thousands of people every year. Find out which food additive is to blame. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 4, 2018 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

A popular sugar additive may have fueled the spread of not one but two superbugs
Two bacterial strains that have plagued hospitals around the country may have been at least partly fueled by a sugar additive in our food products, scientists say. Trehalose, a sugar that is added to a wide range of food products, could have allowed certain strains of Clostridium difficile to become... (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - January 3, 2018 Category: Science Authors: Amina Khan Source Type: news

Sugar additive in cakes has fueled rise of superbug
The study by Baylor College of Medicine in Houston shows that the sugar - known as trehalose - is metabolized by the potentially deadly bacterium Clostridium difficile. (Source: the Mail online | Health)
Source: the Mail online | Health - January 3, 2018 Category: Consumer Health News Source Type: news

Dietary sugar linked to increasing bacterial epidemics
(Baylor College of Medicine) The increasing frequency and severity of healthcare-associated outbreaks caused by bacterium Clostridium difficile have been linked to the widely used food additive trehalose. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 3, 2018 Category: Infectious Diseases Source Type: news

Risk Factors for Hospital-Onset C difficile Identified Risk Factors for Hospital-Onset C difficile Identified
Some antibiotics increased the risk for infection, while others appeared to provide a protective effect, a new study found.Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 29, 2017 Category: Consumer Health News Tags: Internal Medicine News Source Type: news

Is Antibiotic Prescribing by Dentists an Overlooked Problem? Is Antibiotic Prescribing by Dentists an Overlooked Problem?
Use of antibiotics before dental procedures may contribute to community-acquired Clostridium difficile infection.Medscape Reader Polls (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 27, 2017 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news