C. difficile Tied to Increased Graft Loss in Solid Organ Recipients
Proven infections, antibiotic treatments in past three months tied to increased development of CDI (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - August 13, 2018 Category: Respiratory Medicine Tags: Cardiology, Gastroenterology, Infections, Nephrology, Pulmonology, Surgery, Journal, Source Type: news

C. difficile Tied to Increased Graft Loss in Solid Organ Recipients
MONDAY, Aug. 13, 2018 -- For solid organ transplant (SOT) recipients, Clostridium difficile infection (CDI) is associated with increased graft loss, according to a study published in the July issue of the American Journal of Transplantation. Alexia... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 13, 2018 Category: Pharmaceuticals Source Type: news

It ’s Not Yet Clear How to Boost the Microbiome. But Diet Is the Best Bet
The gut microbiome—the billions of bacteria that live inside the human digestive tract—is the focus of some of today’s most exciting and compelling medical research. Studies have linked microbiome-related imbalances to health conditions ranging from depression and Parkinson’s disease to heart disease. Some researchers have even started referring to the microbiome as a “forgotten organ” because of the indispensable role it plays in human health. It’s fairly clear that the foods a person eats—or doesn’t eat—can affect the composition of his or her microbiome. Resear...
Source: TIME: Health - August 8, 2018 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized healthytime Research Source Type: news

C. diff Infection and Graft Loss in Solid Organ Transplants C. diff Infection and Graft Loss in Solid Organ Transplants
The development of C. difficile infection following solid organ transplantation may contribute to an increased risk of graft loss, a new study suggests.American Journal of Transplantation (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - August 7, 2018 Category: Surgery Tags: Transplantation Journal Article Source Type: news

Comparative efficacy of treatments for Clostridium difficile infection: a systematic review and network meta-analysis
This Systematic Review noted fidaxomicin provides sustained symptomatic cure most frequently and is better treatment than vancomycin except in those with severe infections, and could be considered 1stline therapy, whilst metronidazole should not be recommended (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 18, 2018 Category: Consumer Health News Source Type: news

The benefits of MCT oil
(Natural News) You may have heard of the many benefits of coconut oil, especially to your skin. But what you may not know is that coconut oil also has potent antibacterial properties, thanks to its medium-chain triglyceride (MCT) content. Clostridium difficile is a hardy bacteria known to survive even the onslaught of antibiotics. However, it... (Source: NaturalNews.com)
Source: NaturalNews.com - July 9, 2018 Category: Consumer Health News Source Type: news

Germ-blasting robot sets its sights on fighting C. difficile outbreaks
Germ-blasting robot Solaris Lytbot is a portable "no-touch" disinfection technology that uses pulsed UV light to eliminate pathogens, but experts are worried cash-strapped hospitals will use automated disinfection instead of humans to save money. (Source: CBC | Health)
Source: CBC | Health - July 8, 2018 Category: Consumer Health News Tags: News/Canada/Toronto Source Type: news

A full hospital does not necessarily mean higher infection risk
Most people probably figure the more people in a hospital, the more likely a patient is to get commonly-transferable illnesses, such as Clostridium difficile. (Source: Health News - UPI.com)
Source: Health News - UPI.com - July 2, 2018 Category: Consumer Health News Source Type: news

Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study
This research article covers a UK study (n=64,141 penicillin allergy [PA] and 237,258 matched comparators) noted documented penicillin allergy was linked to increased risk of MRSA (HR 1.69; 95% CI 1.51 to 1.90) and C difficile (1.26; 1.12 to 1.40) that was mediated by increased use of alternative (non- β lactam) antibiotics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 29, 2018 Category: Consumer Health News Source Type: news

Penicillin Allergy Linked to MRSA, C. Difficile Risk
THURSDAY, June 28, 2018 -- There is a correlation for documented penicillin allergy with increased risk of methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile, which is mediated by increased use of β-lactam alternative... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 28, 2018 Category: Pharmaceuticals Source Type: news

Patients with penicillin allergy at increased risk of ‘superbug’ infections
Patients who have a record of a penicillin allergy are at an increased risk of developing the drug resistant infection MRSA and healthcare-associated infection C difficile, according to researchers. (Source: Nursing Times)
Source: Nursing Times - June 28, 2018 Category: Nursing Source Type: news

Penicillin Allergy Linked to MRSA, C difficile Infections Penicillin Allergy Linked to MRSA, C difficile Infections
Patients with documented penicillin allergy have a greater risk of developing new methicillin-resistant Staphylococcus aureus and Clostridium difficile infections, a study has found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 27, 2018 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Patients believed allergic to penicillin have increased risks of MRSA and C. difficile
(Massachusetts General Hospital) Analysis of outpatient records of large number of British patients reveals that those believed to be allergic to penicillin have significantly increased risks of contracting the dangerous infections MRSA and C. difficile. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 27, 2018 Category: Infectious Diseases Source Type: news

'Remarkable drop' in C. difficile infections found at Canadian hospitals
Rates of C. difficile, the most common infectious cause of diarrhea in hospitalized patients in Canada, have decreased 36 per cent. Researchers say improvements in infection-control measures may have contributed to the decrease. (Source: CBC | Health)
Source: CBC | Health - June 25, 2018 Category: Consumer Health News Tags: News/Health Source Type: news

'Remarkable drop' in C. difficile infections at Canadian hospitals
Rates of C. difficile, the most common infectious cause of diarrhea in hospitalized patients in Canada, have decreased 36 per cent. Researchers say improvements in infection control measures may have contributed to the decrease. (Source: CBC | Health)
Source: CBC | Health - June 25, 2018 Category: Consumer Health News Tags: News/Health Source Type: news

Deep-sea sponges may stem the antibiotic-resistance crisis
Researchers from Florida Atlantic University found that out of 50 sponges, more than half contain so-called 'good bacteria' that fight off life-threatening infections such as C.difficile. (Source: the Mail online | Health)
Source: the Mail online | Health - June 25, 2018 Category: Consumer Health News Source Type: news

Clostridium difficile infections have decreased 36 percent in Canadian hospitals
(Canadian Medical Association Journal) Rates of C. difficile infections have decreased 36 percent in hospitals across Canada, although the virulent NAP1 strain associated with severe illness and deaths is the most common strain, according to research published in CMAJ (Canadian Medical Association Journal). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 25, 2018 Category: International Medicine & Public Health Source Type: news

Aimee Shen of Tufts Medical School granted PATH award from Burroughs Wellcome Fund
(Tufts University, Health Sciences Campus) Microbiologist Aimee Shen of Tufts University School of Medicine has received a prestigious 2018 Investigator in the Pathogenesis of Infectious Disease award from the Burroughs Wellcome Fund for her research on C. difficile. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 25, 2018 Category: Infectious Diseases Source Type: news

Fecal Transplant Promising Primary Therapy for C diff Fecal Transplant Promising Primary Therapy for C diff
Fecal microbiota transplantation can be used for the first-line treatment of C difficile, and it might also have an effect on neurologic and autoimmune diseases, such as autism and alopecia areata.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 19, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Deep-sea marine sponges may hold key to antibiotic drug resistance
(Florida Atlantic University) FAU's Harbor Branch houses more than 1,000 strains of actinobacteria, one of the most prolific microbial groups for the production of natural products. Derived from sea sponges and other macro-organisms, several strains were identified for their potent antifungal activity, for anti-MRSA activity, and for both antifungal and antibacterial activities. A key finding was the identification of a strain that produced metabolites that are more potent than the bacterial antibiotic, vancomycin, against C. difficile. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 19, 2018 Category: Infectious Diseases Source Type: news

Test can identify ICU patients at most risk of serious infections
A new test can identify intensive care patients at highest risk of potentially life-threatening secondary infections, including from antibiotic-resistant bacteria such as MRSA and C difficile, according to UK researchers. (Source: Nursing Times)
Source: Nursing Times - June 18, 2018 Category: Nursing Source Type: news

Test can identify patients in intensive care at risk of life-threatening infections
(University of Cambridge) Patients in intensive care units are at significant risk of potentially life-threatening secondary infections, including from antibiotic-resistant bacteria such as MRSA and C. difficile. Now, a new test could identify those at greatest risk -- and speed up the development of new therapies to help at-risk patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 13, 2018 Category: International Medicine & Public Health Source Type: news

Bezlotoxumab for prevention of recurrence of Clostridium difficile infection
This evidence review states that Bezlotoxumab is a monoclonal antibody that neutralises C. difficile toxin B, licensed for prevention of infection recurrence in those at high risk. The authors conclude that due to limitations of the evidence and the high cost of treatment, it is difficult to see a place in therapy for this agent. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 8, 2018 Category: Consumer Health News Source Type: news

Killing bacteria by silencing genes may be alternative to antibiotics
(Penn State) A new approach to killing C. difficile that silences key bacterial genes while sparing other bacteria may provide a new way to treat the most common hospital-acquired bacterial infection in the United States, according to researchers. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 6, 2018 Category: Infectious Diseases Source Type: news

Do You Have the Right Stuff to Be a Stool Donor?
Altruism, and a little financial incentive, can be motivating factors. (Source: NYT Health)
Source: NYT Health - June 5, 2018 Category: Consumer Health News Authors: RONI CARYN RABIN Tags: Transplants Feces Antibiotics Digestive Tract Clostridium Difficile (Bacterium) Infections Source Type: news

Clostridium difficile Patients on Opioids Fare Much Worse Clostridium difficile Patients on Opioids Fare Much Worse
The slowing of gut motility related to opioids might lead to more severe infection, new research shows.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 3, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Antibiotics Weren ’ t Used to Cure These Patients. Fecal Bacteria Were.
In a small study, doctors used so-called fecal transplants to treat a serious gut infection in patients. The transplants, from healthy donors, were as effective as antibiotics. (Source: NYT Health)
Source: NYT Health - June 2, 2018 Category: Consumer Health News Authors: GINA KOLATA Tags: Feces Antibiotics Transplants Digestive Tract Bacteria Clostridium Difficile (Bacterium) Clinical Trials Infections Colitis New England Journal of Medicine University of Oslo Source Type: news

The Latest Poop On Fecal Transplants Vs. Antibiotics For C. Difficile Diarrhea
How can more poop actually help with severe diarrhea? Well, when the diarrhea is caused by the antibiotic-resistant bacteria Clostridium difficile, a poop transplant may help get to the bottom of the problem. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - June 2, 2018 Category: Pharmaceuticals Authors: Bruce Y. Lee, Contributor Source Type: news

Fecal Transplants vs. Antibiotics. The Test.
Instead of waiting until antibiotics have failed before trying fecal transplants, researchers tried giving the fecal bacteria first. (Source: NYT Health)
Source: NYT Health - June 2, 2018 Category: Consumer Health News Authors: GINA KOLATA Tags: Feces Antibiotics Transplants Digestive Tract Bacteria Clostridium Difficile (Bacterium) Clinical Trials Infections Colitis New England Journal of Medicine University of Oslo Source Type: news

Antibiotics Didn ’ t Cure Their Infections. Fecal Bacteria Did.
In a small study, fecal transplants ended a persistent, dangerous gut infection just as effectively as drugs. (Source: NYT Health)
Source: NYT Health - June 2, 2018 Category: Consumer Health News Authors: GINA KOLATA Tags: Feces Antibiotics Transplants Digestive Tract Bacteria Clostridium Difficile (Bacterium) Clinical Trials Infections Colitis New England Journal of Medicine University of Oslo Source Type: news

UCI-Harvard research may help combat the deadly gastrointestinal infection C. diff
(University of California - Irvine) Clostridium difficile   infection is the most common cause of antibiotic-associated diarrhea in developed countries. Researchers have discovered how the C. diff toxin B recognizes the human Frizzled protein, the receptor it uses to invade intestinal cells and lead to deadly gastrointestinal infections. The findings, published in Science, could pave the way for new C. diff antitoxins and also show potential for the development of novel anti-cancer drugs. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 11, 2018 Category: International Medicine & Public Health Source Type: news

Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B
Clostridium difficile infection is the most common cause of antibiotic-associated diarrhea in developed countries. The major virulence factor, C. difficile toxin B (TcdB), targets colonic epithelia by binding to the frizzled (FZD) family of Wnt receptors, but how TcdB recognizes FZDs is unclear. Here, we present the crystal structure of a TcdB fragment in complex with the cysteine-rich domain of human FZD2 at 2.5-angstrom resolution, which reveals an endogenous FZD-bound fatty acid acting as a co-receptor for TcdB binding. This lipid occupies the binding site for Wnt-adducted palmitoleic acid in FZDs. TcdB binding locks th...
Source: ScienceNOW - May 10, 2018 Category: Science Authors: Chen, P., Tao, L., Wang, T., Zhang, J., He, A., Lam, K.-h., Liu, Z., He, X., Perry, K., Dong, M., Jin, R. Tags: Biochemistry, Microbiology reports Source Type: news

Probiotics can prevent bacterial diarrhoea in hospital patients receiving antibiotics
This NIHR Signal gives commentary on an updated Cochrane Review. It provides new evidence suggesting probiotics may be beneficial for hospitalised patients at risk of C. Difficile infection. Probiotics may be suitable for use in high-risk patients needing antibiotics, for example, older adults with underlying illness. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 9, 2018 Category: Consumer Health News Source Type: news

Probiotics Effective for Primary Prevention of C. Diff Probiotics Effective for Primary Prevention of C. Diff
Probiotics are effective for preventing Clostridium difficile infection (CDI) in patients treated with antibiotics, according to findings from two research groups.Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 7, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

New Help for Managing Clostridium difficile Infection New Help for Managing Clostridium difficile Infection
New guidelines from IDSA/SHEA highlight best practices for treatingC difficile infection. Dr David Johnson provides insight for all providers who must be cognizant of this widespread problem.Medscape Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 26, 2018 Category: Consumer Health News Tags: Gastroenterology Commentary Source Type: news

Probiotics useful in the fight against infection prevention
(Society for Healthcare Epidemiology of America) Probiotics may be a relatively safe, simple, and low-cost solution for preventing Clostridium difficile infections (CDI) in hospital settings, according to two studies published today in Infection Control& Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America. Both studies show that treating patients who received antibiotics with multi-strain probiotics, cut down on CDI incidence rates over time. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 26, 2018 Category: Infectious Diseases Source Type: news

Artificial Differences in C difficile Infection Rates Artificial Differences in C difficile Infection Rates
This report looks at how testing methods and frequency may have impacted the reported rates of C difficile infection.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 19, 2018 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

C. Difficile Risk Higher With Stoma Reversal Versus Colectomy
WEDNESDAY, April 18, 2018 -- Patients who undergo elective stoma reversal have a higher incidence of postoperative Clostridium difficile infection versus patients who undergo elective colectomy, according to a study published in the May issue of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 18, 2018 Category: Pharmaceuticals Source Type: news

Study finds NYC mice may be hotbeds of antibiotic-resistant bacteria
Apartment-dwelling rodents all over the city carry treatment-resistant C. difficile, E. coli, Shigella and Salmonella that can be transmitted to residents, the team found. (Source: the Mail online | Health)
Source: the Mail online | Health - April 17, 2018 Category: Consumer Health News Source Type: news

Study finds NYC mice are hotbeds of antibiotic-resistant bacteria
Apartment-dwelling rodents all over the city carry treatment-resistant C. difficile, E. coli, Shigella and Salmonella that can be transmitted to residents, the team found. (Source: the Mail online | Health)
Source: the Mail online | Health - April 17, 2018 Category: Consumer Health News Source Type: news

NYC Mice Are Carrying Antibiotic-Resistant Germs
People who live in cities are used to the company of furry vermin. But a new study reveals that mice and men may be sharing much more than just living quarters. In a study published in the journal mBio, researchers led by Dr. Ian Lipkin, professor of epidemiology at the Mailman School of Public Health at Columbia University, studied the gut microbes of 416 mice collected from mostly residential buildings all over New York City. Lipkin and his team did a thorough genetic analysis of the microbes they extracted from the feces of the mice, and found that they contained a number of disease-causing bacteria. Nearly 40% of the ...
Source: TIME: Health - April 17, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Bacteria healthytime Source Type: news

Clostridium difficile Infection: Prevention and Treatment Clostridium difficile Infection: Prevention and Treatment
This review provides evidence-based pointers on the prevention and treatment of C. difficile infection. What are the options, and how effective are they?American Family Physician (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 5, 2018 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

Researchers define target and mechanism of antibacterial drug fidaxomicin (dificid)
(Rutgers University) A team of Rutgers University and international scientists has determined the molecular target and mechanism of the antibacterial drug fidaxomicin (trade name Dificid). Fidaxomicin was approved in 2011 for treatment of the CDC 'urgent threat' bacterial pathogen Clostridium difficile (C. diff) and currently is one of two front-line drugs for treatment of C. diff. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 29, 2018 Category: Infectious Diseases Source Type: news

Medication Exposure and Risk of Recurrent C. diff Infection Medication Exposure and Risk of Recurrent C. diff Infection
How does exposure to medications such as antibiotics, corticosteroids, and acid-reducers impact the risk of recurrent C. difficile infection? Does risk differ according to living environment?Journal of the American Geriatrics Society (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 28, 2018 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news

A moveable feast: Antibiotics give C. diff a nutrient-rich environment, no competition
(North Carolina State University) Using a mouse model, researchers from North Carolina State University have found that antibiotic use creates a " banquet " for Clostridium difficile (C. diff), by altering the native gut bacteria that would normally compete with C. diff for nutrients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2018 Category: International Medicine & Public Health Source Type: news

Machine learning model provides rapid prediction of C. difficile infection risk
(Massachusetts General Hospital) Investigators from Massachusetts General Hospital, the University of Michigan and Massachusetts Institute of Technology have developed investigational 'machine learning' models, specifically tailored to individual institutions, that can predict a patient's risk of developing C. difficile much earlier than it would be diagnosed with current methods. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 26, 2018 Category: Infectious Diseases Source Type: news

Metabolite therapy proves effective in treating C. difficile in mice
FINDINGSA team of UCLA researchers found that a metabolite therapy was effective in mice for treating a serious infection of the colon known as Clostridium difficile infection, or C. difficile.  Mice that were infected with C. difficile were treated with an experimental drug called CSA13, which increased levels of four protective metabolites — molecules that help fuel, maintain and mediate cells. Compared with mice that did not receive CSA13, the mice treated with the drug were significantly more likely to survive the infection, had lower rates of weight loss and — after the treatment was stopped — w...
Source: UCLA Newsroom: Health Sciences - March 20, 2018 Category: Universities & Medical Training Source Type: news

Evaluation of the US Food and Drug Administration sentinel analysis tools in confirming previously observed drug-outcome associations: the case of clindamycin and Clostridium difficile infection - Carnahan RM, Kuntz JL, Wang SV, Fuller C, Gagne JJ, Leonard CE, Hennessy S, Meyer T, Archdeacon P, Chen CY, Panozzo CA, Toh S, Katcoff H, Woodworth T, Iyer A, Axtman S, Chrischilles EA.
PURPOSE: The Food and Drug Administration's Sentinel System developed parameterized, reusable analytic programs for evaluation of medical product safety. Research on outpatient antibiotic exposures, and Clostridium difficile infection (CDI) with non-user r... (Source: SafetyLit)
Source: SafetyLit - March 19, 2018 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news

Two Simple Ways to Improve Diagnosis of Infectious Diseases Two Simple Ways to Improve Diagnosis of Infectious Diseases
Recent data support taking a hard look at clinical practices surrounding diagnostic testing in C difficile and bloodstream infections.Society for Healthcare Epidemiology of America (SHEA) (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - March 15, 2018 Category: Infectious Diseases Tags: Infectious Diseases Viewpoint Source Type: news

Long-term Effects of Fecal Transplant in Recurrent C. Diff Long-term Effects of Fecal Transplant in Recurrent C. Diff
Treatment of recurrent C. difficile infection with fecal microbiota transplantation has been shown to be safe in the short term, but might there be long-term adverse effects?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 13, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news