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Guidelines Issued on Contact Precautions for MRSA, C. difficile
The Society for Healthcare Epidemiology of America has issued guidelines on how long contact precautions in acute-care hospitals should persist for numerous drug-resistant... (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - January 12, 2018 Category: Primary Care Source Type: news

Extended-pulsed Fidaxomicin Bests Vancomycin for C Diff in Older People Extended-pulsed Fidaxomicin Bests Vancomycin for C Diff in Older People
Extended-pulsed fidaxomicin, delivering 20 doses over a longer time period after initial daily dosing, appears superior to standard-dose vancomycin for sustained cure of Clostridium difficile infection in patients age 60 or older, according to results from an open-label randomized trial.Reuters Health Information (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - January 8, 2018 Category: Infectious Diseases Tags: Gastroenterology News Source Type: news

New treatment launched to reduce C. difficile recurrence
A new therapy for the prevention of recurrence of Clostridium difficile infection has been launched in the UK. (Source: Nursing Times)
Source: Nursing Times - January 8, 2018 Category: Nursing Source Type: news

Sugar alternative is NOT so healthy after all: Trehalose, a substitute used in many processed foods, is giving rise to a superbug, severe disease, study warns
(Natural News) A sugar alternative that was deemed “healthy” appears to be not so healthy after all. A new study discovered that the artificial sugar additive known as trehalose, which is found in many food products, potentially played a role in the increase of a deadly superbug called Clostridium difficile, which is a bacterium that causes infection,... (Source: NaturalNews.com)
Source: NaturalNews.com - January 6, 2018 Category: Consumer Health News Source Type: news

Updated meta-analysis of controlled observational studies: proton-pump inhibitors and risk of Clostridium difficile infection
This meta-analysis concludes that despite substantial statistical and clinical heterogeneity, the findings indicate a significant associated risk of incident CDI among PPI users, especially in general ward patients. The authors state that establishing a guideline for the use of PPI may help in the future with the control of CDI. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 4, 2018 Category: Consumer Health News Source Type: news

Unintended Consequences: Steps to Fight Sepsis Increase C. diff: Uptick in antibiotic use sets up C. diff infections.
This article reports on the effort of Mount Sinai Hospital in New York City to identify potential sepsis cases and conduct antibiotic treatment that led to an increase in 12 Clostridium difficile infections. Topics mentioned include a national initiative to rein in antibiotic use and overuse, increase in antibiotic use after implementation of a sepsis care bundle, and an increase in risk for C. diff due to broad spectrum antibiotics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 4, 2018 Category: Consumer Health News Source Type: news

Medical News Today: Food additive to blame for C. difficile epidemic
Clostridium difficile infections are on the rise, and they now routinely kill thousands of people every year. Find out which food additive is to blame. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 4, 2018 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

A popular sugar additive may have fueled the spread of not one but two superbugs
Two bacterial strains that have plagued hospitals around the country may have been at least partly fueled by a sugar additive in our food products, scientists say. Trehalose, a sugar that is added to a wide range of food products, could have allowed certain strains of Clostridium difficile to become... (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - January 3, 2018 Category: Science Authors: Amina Khan Source Type: news

Sugar additive in cakes has fueled rise of superbug
The study by Baylor College of Medicine in Houston shows that the sugar - known as trehalose - is metabolized by the potentially deadly bacterium Clostridium difficile. (Source: the Mail online | Health)
Source: the Mail online | Health - January 3, 2018 Category: Consumer Health News Source Type: news

Dietary sugar linked to increasing bacterial epidemics
(Baylor College of Medicine) The increasing frequency and severity of healthcare-associated outbreaks caused by bacterium Clostridium difficile have been linked to the widely used food additive trehalose. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 3, 2018 Category: Infectious Diseases Source Type: news

Risk Factors for Hospital-Onset C difficile Identified Risk Factors for Hospital-Onset C difficile Identified
Some antibiotics increased the risk for infection, while others appeared to provide a protective effect, a new study found.Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 29, 2017 Category: Consumer Health News Tags: Internal Medicine News Source Type: news

Is Antibiotic Prescribing by Dentists an Overlooked Problem? Is Antibiotic Prescribing by Dentists an Overlooked Problem?
Use of antibiotics before dental procedures may contribute to community-acquired Clostridium difficile infection.Medscape Reader Polls (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 27, 2017 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Increased Risk of C. difficile Infection for Next Bed Occupant Increased Risk of C. difficile Infection for Next Bed Occupant
This unique study of sequential patients who occupied the same hospital bed demonstrated that the hazards of antibiotic use may extend beyond the individual patient.Evidence-Based Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 21, 2017 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

Antibiotic Overuse Blind Spot: Dental Prescribing Antibiotic Overuse Blind Spot: Dental Prescribing
Recent data shine a light on a possible cause of community-acquired Clostridium difficile infection: the antibiotics prescribed by dentists.Medscape Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 20, 2017 Category: Consumer Health News Tags: Infectious Diseases Expert Column Source Type: news

Fecal Transplant Works for C difficile Infection Long-term Fecal Transplant Works for C difficile Infection Long-term
FMT treatment is safe and effective in both the short- and long-term and should be considered earlier as a treatment option for patients with chronic C difficile infection, a study found.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 19, 2017 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Guidance for Industry: Enforcement Policy Regarding Investigational New Drug Requirements for Use of Fecal Microbiota for Transplantation to Treat Clostridium difficile Infection Not Responsive to Standard Therapies
(Source: What's New at CBER)
Source: What's New at CBER - December 15, 2017 Category: Biomedical Science Source Type: news

Effect of Oral Capsule- vs Colonoscopy-Delivered Fecal Microbiota Transplantation on Recurrent Clostridium difficile Infection: A Randomized Clinical Trial
This research article has led to a Practice Changing Update on DynaMed Plus. It concludes that oral delivery of fecal microbial transplantation is as effective as infusion by colonoscopy for preventing recurrence of C. difficile infection in patients with recurrent infections. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 13, 2017 Category: Consumer Health News Source Type: news

Faecal transplant effectively treats recurrent or unresponsive Clostridium difficile
This review concludes that faecal transplant appeared to be an effective and safe way to treat recurring or unresponsive diarrhoea from C. difficile, although these studies had wide variations in preparation and administration. The review provides useful information about the best delivery route for the transplant, and finds that frozen or fresh samples are equally effective. A recent trial shows that taking a capsule may also be an alternative effective and acceptable route for transplant. However, there remains uncertainty about how best to prepare the faecal transplant, and evidence is needed to guide best practice. (So...
Source: Current Awareness Service for Health (CASH) - December 6, 2017 Category: Consumer Health News Source Type: news

Feces capsules are 96% effective at treating C. difficile
Researchers from the University of Calgary found the nauseating tablets, which have no scent or taste, are as effective as colonoscopies for treating such recurrent infections but with fewer side effects. (Source: the Mail online | Health)
Source: the Mail online | Health - December 4, 2017 Category: Consumer Health News Source Type: news

Sanofi ends development of C. difficile vaccine
(Reuters) - Pharmaceutical company Sanofi SA said on Friday that it had ended development of an experimental vaccine for Clostridium difficile infection, after an early look at late-stage trial results indicated a low probability for success. (Source: Reuters: Health)
Source: Reuters: Health - December 1, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Sanofi ends development of Clostridium difficile vaccine
(Reuters) - Pharmaceutical company Sanofi SA said on Friday that it had ended development of an experimental vaccine for Clostridium difficile infection, after an early look at late-stage trial results indicated a low probability for success. (Source: Reuters: Health)
Source: Reuters: Health - December 1, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Bezlotoxumab cost effective for Clostridium difficile infection
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - December 1, 2017 Category: Drugs & Pharmacology Source Type: news

'Poop pill' capsule research paves the way for simpler C. difficile treatment
(University of Calgary) An Alberta-led clinical trial has shown Fecal Microbiota Transplant (FMT) is effective in treating clostridium difficile (C. difficile) infections whether delivered by colonoscopy or by swallowing capsules. The finding, published today in the Journal of the American Medical Association, could revolutionize and broaden the use of FMT, which restores the healthy balance of bacteria living in the intestine by transferring a healthy donor's stool to the gut of a person with C. difficile. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 30, 2017 Category: Biology Source Type: news

Fecal Transplant by Capsule, Colonoscopy for Recurrent C diff Fecal Transplant by Capsule, Colonoscopy for Recurrent C diff
Fecal microbiota transplantation (FMT) prevents recurrent C. difficile infection whether delivered by oral capsule or by colonoscopy, according to results from a randomized noninferiority trial.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 29, 2017 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

'Poop pills' as good as colonoscopy to treat C. difficile: study
When it comes to treating Clostridium difficile with a fecal transplant — yes, human poop — swallowing a frozen capsule appears to have far less of an "ick factor" and works as well as delivering the therapy via colonoscopy, researchers say. (Source: CBC | Health)
Source: CBC | Health - November 29, 2017 Category: Consumer Health News Tags: News/Canada/Edmonton Source Type: news

Fecal Microbiota Transplant for Recurrent C. difficile: Capsule Delivery Seems as Effective as Colonoscopy
Fecal microbiota transplantation in capsule form appears as effective as delivery via colonoscopy for preventing Clostridium difficile recurrence, according to a noninferiority trial in JAMA... (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - November 29, 2017 Category: Primary Care Source Type: news

Fecal Microbiota Transplant for Refractory C. Difficile Fecal Microbiota Transplant for Refractory C. Difficile
This meta-analysis aimed to systematically evaluate the effectiveness of fecal microbiota transplantation as treatment for recurrent and refractory C. difficile infection.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 29, 2017 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

GenePOC Launches its GenePOC(TM) CDiff Test in the United States
GenePOC announces the launch and FDA clearance of its Clostridium difficile molecular test in US QUÉBEC CITY, November 28, 2017 -- (Healthcare Sales & Marketing Network) -- GenePOC Inc. (GenePOC), a member of the Debiopharm Group™, is proud to a... Diagnostics, FDA, Product Launch GenePOC, Debiopharm, GenePOC CDiff, revogene, C. difficile (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 28, 2017 Category: Pharmaceuticals Source Type: news

Capsule research paves way for simpler C. difficile treatment
(Alberta Health Services) An Alberta-led clinical trial has shown Fecal Microbiota Transplant (FMT) is as effective in treating clostridium difficile (C. difficile) infections whether delivered by colonoscopy or by swallowing capsules. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 28, 2017 Category: Infectious Diseases Source Type: news

Clostridium Difficile Infection in the Intensive Care Unit Clostridium Difficile Infection in the Intensive Care Unit
The diagnosis and treatment of C. difficile infections among ICU patients presents unique challenges.Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 27, 2017 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

Why you should only use antibiotics if truly necessary
Let’s be honest: most parents feel better when their sick child is prescribed an antibiotic. There’s just something so reassuring about having a prescription. It’s hard to feel like all you can do is wait and give your child TLC; it feels better to do something. Even when the doctor says that your child has a virus, and explains that antibiotics treat bacteria, not viruses, it’s common for parents to think: but what if there is even a little chance that there is a bacterial infection along with — or instead of — the virus? It can’t hurt to be safe, right? But that’s the thing...
Source: Thrive, Children's Hospital Boston - November 9, 2017 Category: Pediatrics Authors: Claire McCarthy Tags: Ask the Expert Health & Wellness antibiotics Claire McCarthy MD Source Type: news

After repeated C. diff infections, people change their behaviors
(Loyola University Health System) After suffering repeated bouts of debilitating Clostridium difficile infections, many patients significantly change their behaviors, but some precautions may do little to prevent future infections, according to a first-of-its-kind study. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 7, 2017 Category: Infectious Diseases Source Type: news

Outpatient antibiotics increase risk for C. difficile in the community
Research shows outpatient antibiotic use can increase a person's risk of developing " C. difficile " infection after discharge from the emergency room. (Source: Health News - UPI.com)
Source: Health News - UPI.com - October 26, 2017 Category: Consumer Health News Source Type: news

Outpatient antibiotics raise risk for acquiring C. difficile infection in the community
(Infectious Diseases Society of America) Outpatient antibiotic use is a primary risk factor for acquiring Clostridium difficile infection in the community, reinforcing the need for appropriate prescribing in this setting, a new study published in Open Forum Infectious Diseases confirms. The findings also suggest that a recent visit to the emergency department, independent of antibiotic use, may also be a risk factor for the infection, which can cause life-threatening diarrhea. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 26, 2017 Category: Infectious Diseases Source Type: news

Dental Antibiotics Could Be Adding to C difficile Cases Dental Antibiotics Could Be Adding to C difficile Cases
Conversations about stewardship have tended to focus on hospitals and leave out dentists. A study finds prescription information often is not being shared between medical and dental providers.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 16, 2017 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

HealthWatch: Antibiotics Linked To Superbug, Divorce May Be Genetic
BOSTON (CBS) – A new study links antibiotics prescribed by dentists to the superbug C. difficile. Minnesota health officials found almost 40 percent of dentists are not following guidelines and are overprescribing antibiotics. C. difficile is a serious intestinal infection but if patients get symptoms, they are more likely to call their doctors and not their dentist, so dentists aren’t necessarily seeing the bad outcomes. And while it’s completely appropriate for a dentist to prescribe an antibiotic for a dental infection, many are still prescribing them prophylactically to patients with certain heart con...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 9, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Local News Syndicated Local Antibiotics C. difficile Divorce Dr. Mallika Marshall HealthWatch Source Type: news

Automation and Antimicrobial Stewardship Automation and Antimicrobial Stewardship
Want to know current rates of C difficile infection or nosocomial pneumonia? Information technology makes us'smarter and more efficient,'says Dr Lucas Schulz.Medscape Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 6, 2017 Category: Consumer Health News Tags: Infectious Diseases Article Source Type: news

Antibiotics for dental procedures linked to superbug infection, study shows
(Infectious Diseases Society of America) Dental procedures are an overlooked source of antibiotic prescribing, which is a concern as these medications increase the risk of developing C. difficile, according to an IDWeek study. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 6, 2017 Category: Infectious Diseases Source Type: news

The World Is Running Out of Much Needed New Antibiotics
Posters: Misuse of antibiotics and risks. Credit: WHOBy Baher KamalROME, Oct 4 2017 (IPS)The world is running out of new antibiotics to combat the growing threat of antimicrobial resistance, a new specialised report warns ahead of this year’s World Antibiotic Awareness Week, adding that most of the drugs currently in the clinical pipeline are modifications of existing classes of antibiotics and are only short-term solutions. The latest World Health Organization (WHO) report on this issue “Antibacterial agents in clinical development – an analysis of the antibacterial clinical development pipeline, includi...
Source: IPS Inter Press Service - Health - October 4, 2017 Category: International Medicine & Public Health Authors: Baher Kamal Tags: Featured Global Headlines Health Human Rights TerraViva United Nations Source Type: news

New study: Sepsis care initiatives may lead to higher C. difficile infection rates, antibiotic resistance
(Elsevier) Healthcare experts have long known the benefits of integrated sepsis care programs, yet less information has been published on potential unintended consequences of these programs. That's changed with a new study that suggests that electronic sepsis screenings and treatment protocols could, in fact, lead to increased use of certain broad-spectrum antibiotics and healthcare facility-onset (HCFO) C. difficile infection (CDI) rates, according to findings published in the October issue of the American Journal of Infection Control (AJIC). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 3, 2017 Category: International Medicine & Public Health Source Type: news

Is your poop the 'right stuff'? Then this Toronto hospital may want it to fight C. difficile
A Toronto medical team wants help saving C. difficile sufferers' lives, after they've run short on donors in their fecal transplant program. (Source: CBC | Health)
Source: CBC | Health - September 28, 2017 Category: Consumer Health News Tags: Radio/As It Happens Source Type: news

Paper of note in Science Translational Medicine 9 (406)
This week’s article describes how targeted antimicrobials may reduce the virulence of Clostridium difficile infection. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 12, 2017 Category: Science Authors: Ferrarelli, L. K. Tags: STKE Editors ' Choice Source Type: news

Summit Therapeutics secures $62m contract to develop ridinilazole for CDI treatment
UK-based drug discovery and development company Summit Therapeutics has secured a contract worth up to $62m to support the clinical and regulatory development of ridinilazole for the treatment of C. difficile infection (CDI). (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - September 11, 2017 Category: Pharmaceuticals Source Type: news

Early Fecal Transplant Improves Survival After Severe C diff Infection Early Fecal Transplant Improves Survival After Severe C diff Infection
Patients with severe Clostridium difficile infection (CDI) who receive early fecal microbiota transplant (FMT) have improved survival, researchers from France report.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - September 7, 2017 Category: Surgery Tags: Gastroenterology News Source Type: news

BREAKTHROUGH as certain probiotics are found to produce powerful antibiotics that kill superbugs
(Natural News) Scientists at the Baylor College of Medicine are saying that next-generation probiotics can reduce the risk of becoming infected with the bacterium Clostridium difficile, also known a C. difficile or C. diff. This is a common bacterial infection which causes gastrointestinal issues such as bowel discomfort and diarrhea. Treatment for the condition usually... (Source: NaturalNews.com)
Source: NaturalNews.com - August 20, 2017 Category: Consumer Health News Source Type: news

Bezlotoxumab (Zinplava) for Prevention of Recurrent Clostridium Difficile Infection
The FDA has approved the fully human monoclonal antibody bezlotoxumab (Zinplava – Merck) for use with antibacterial drug treatment to reduce recurrence of Clostridium difficile infection (CDI) in adults with CDI at high risk for recurrence. It is the first drug to be approved for this indication. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 18, 2017 Category: Consumer Health News Source Type: news

Research opens possibility of reducing risk of gut bacterial infections with next-generation probiotic
(Baylor College of Medicine) In laboratory-grown bacterial communities, the co-administration of probiotic Lactobacillus reuteri and glycerol selectively killed C. difficile. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 9, 2017 Category: International Medicine & Public Health Source Type: news

Rebiotix starts enrolment in Phase III trial of RBX2660 for C. diff infection
US-based clinical-stage microbiome firm Rebiotix has started patient enrolment in a Phase III clinical trial of RBX2660 to prevent recurrent Clostridium difficile (C. diff) infection. (Source: Drug Development Technology)
Source: Drug Development Technology - August 8, 2017 Category: Pharmaceuticals Source Type: news

MassDevice.com +5 | The top 5 medtech stories for August 8, 2017
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters.   5. Why the medtech contract manufacturing M&A trend isn’t slowing down Consolidation is increasingly shaping the medical device industry, but what about players on the other side of the fence? Medtech contract manufactur...
Source: Mass Device - August 8, 2017 Category: Medical Devices Authors: MassDevice Tags: Blog News Well Plus 5 Source Type: news

Luminex Corporation Receives FDA Clearance for ARIES C. difficile Assay
Sample to answer test provides detection of both toxin A and B AUSTIN, Texas, July 24, 2017 -- (Healthcare Sales & Marketing Network) -- Luminex Corporation (NASDAQ: LMNX) today announced that it has received FDA clearance for the ARIES® C. diffici... Diagnostics, FDA Luminex, ARIES, C. difficile Assay, C. difficile (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 24, 2017 Category: Pharmaceuticals Source Type: news