Fecal Transplant Is Linked to a Patient ’s Death, the F.D.A. Warns
The agency said two patients received donated stool that had not been screened for drug-resistant germs, leading it to halt clinical trials until researchers prove proper testing procedures are in place. (Source: NYT Health)
Source: NYT Health - June 14, 2019 Category: Consumer Health News Authors: Denise Grady Tags: Drug Resistance (Microbial) Antibiotics fecal transplant Clostridium Difficile (Bacterium) E Coli (Bacteria) Food and Drug Administration Digestive Tract your-feed-healthcare Source Type: news
Best practices of nucleic acid amplification tests for the diagnosis of clostridioides (clostridium)
(American Society for Microbiology) A new review looks at the challenges of testing for Clostridioides (Clostridium) difficile infection (CDI) and recommendations for newer diagnostic tests. Accurate diagnosis of CDI is critical for effective patient management and implementation of infection control measures to prevent transmission. The research is published this week in the Clinical Microbiology Reviews. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 4, 2019 Category: International Medicine & Public Health Source Type: news
Sweet! How C. difficile toxin A enters intestinal cells
(Boston Children's Hospital) Clostridiodes difficile infection has become a leading cause of severe, sometimes fatal diarrheal illness, with the bacterium's toxins causing the damage. New work cements our knowledge of how C. diff's two primary toxins, A and B, slip into intestinal cells, the first step toward a possible treatment that doesn't involve antibiotics. This latest study, on toxin A, shows its activity can be blocked with molecules already being developed for various medical indications. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 3, 2019 Category: Infectious Diseases Source Type: news
The cost impact of PCT-guided antibiotic stewardship versus usual care for hospitalised patients with suspected sepsis or lower respiratory tract infections in the US: A health economic model analysis
Procalcitonin is a biomarker that supports clinical decision-making on when to initiate and discontinue antibiotic therapy. Several cost (-effectiveness) analyses have been conducted on Procalcitonin-guided antibiotic stewardship, but none mainly based on US originated data. Using a Procalcitonin-algorithm to guide antibiotic use in sepsis and hospitalised lower respiratory tract infection patients is expected to generate cost-savings to the hospital and lower rates of antibiotic resistance and C.difficile infections. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 29, 2019 Category: Consumer Health News Source Type: news
Bone and joint infections: are oral antibiotics safe and effective compared with intravenous antibiotics?
A UK multicentre trial including 1,054 adults with acute or chronic bone or joint infections found that using oral antibiotics in the first 6 weeks of treatment did not increase the risk of treatment failure within 1 year, compared with using intravenous antibiotics. People in the intravenous group experienced more intravenous catheter complications and had longer hospital stays than people in the oral group. There was no significant difference between the groups in the incidence of Clostridium difficile diarrhoea or the percentage of participants reporting serious adverse events. The potential for a difference in the long...
Source: Current Awareness Service for Health (CASH) - May 29, 2019 Category: Consumer Health News Source Type: news
Improper Proton Pump Inhibitor Prescriptions Criticized Improper Proton Pump Inhibitor Prescriptions Criticized
Popularity of the stomach- and intestine-protecting drugs has skyrocketed, but related adverse events, like osteoporotic fractures, C difficile infection, and pneumonia, are problematic.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 22, 2019 Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Fecal microbiota transplant found safe and effective in children with C. difficile
(Boston Children's Hospital) Fecal microbiota transplant (FMT), or the transfer of stool from a healthy donor to a patient, has been found effective in reversing severe, recurring diarrheal infections from Clostridiodes difficile in adults by restoring a normal microbiome. Now, the largest study to date of FMT in children finds the procedure to be safe and effective in eradicating an infection that is on the rise among children, even those without known risk factors. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 16, 2019 Category: International Medicine & Public Health Source Type: news
Clostridium difficile infection objectives
These resources set out the objectives for acute trusts and clinical commissioning groups to make continuous improvement in Clostridium difficile infection (CDI) care. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 15, 2019 Category: Consumer Health News Source Type: news
Medical News Today: Everything you need to know about fecal transplants
Fecal transplants are a recent development in the treatment of several conditions, including Clostridium difficile infections. Learn more about this treatment and the emerging research on it here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 8, 2019 Category: Consumer Health News Tags: GastroIntestinal / Gastroenterology Source Type: news
Each Added Day of Postop Antibiotics Ups Risk of Kidney Injury, C. Diff Infection Each Added Day of Postop Antibiotics Ups Risk of Kidney Injury, C. Diff Infection
Each additional day of surgical antimicrobial prophylaxis increases the risks of acute kidney injury (AKI) and Clostridium difficile infection and does not lead to reductions in surgical site infections (SSIs), researchers say.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - May 3, 2019 Category: Orthopaedics Tags: General Surgery News Source Type: news
C-Path, CDISC release therapeutic area standard to drive research forward for CDAD
(Critical Path Institute (C-Path)) The Critical Path Institute (C-Path) and CDISC are pleased to announce the release of a global Therapeutic Area Standard, which describes how to use CDISC standards to represent data in research studies pertaining to Clostridium difficile associated diarrhea (CDAD). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 2, 2019 Category: International Medicine & Public Health Source Type: news
DTB Select: Comparison of antibiotics for Clostridium difficile infection
Synopsis and clinical commentary is provided for a meta-analysis of 24 RCTs (n=5,631) that compared 13 drug treatments for Clostridium difficile which found that fidaxomicin was the most effective treatment in providing a long-term cure. Metronidazole was ranked 11th. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news
Fecal Microbiota Transplantation Is Superior to Fidaxomicin for Treatment of Recurrent Clostridium difficile Infection
RCT (n=64) reports superior clinical& microbiological resolution of infection in 17 FMT patients (71%) vs 8 fidaxomicin patients (33%) and 3 vancomycin patients (19%); P = 0.009 for FMTv vs fidaxomicin; P = 0.001 for FMTv vs vancomycin and P = 0.31 for fidaxomicin vs vancomycin. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news
More infection cases to be assigned to trusts
The number of cases of C difficile reported by hospitals is expected to increase after changes in how cases are measured. (Source: HSJ)
Source: HSJ - April 24, 2019 Category: UK Health Source Type: news
Revealed: The secret superpower that makes C. difficile so deadly
(University of Virginia Health System) A new discovery about dangerous C. difficile diarrhea has identified a new way that the bacteria -- and possibly others like it -- cause severe disease. C. diff is the most common hospital-acquired infection and estimated to result in 453,000 cases per year, with 29,300 associated deaths. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 23, 2019 Category: Infectious Diseases Source Type: news
