Oral FMT on Par With Colonic FMT for Recurrent C difficile Oral FMT on Par With Colonic FMT for Recurrent C difficile
Freeze-dried, encapsulated fecal microbiota transplantation (FMT) has a safety and effectiveness profile similar to that of liquid colonic FMT, without the procedural risks of colonoscopy.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - October 31, 2022 Category: Gastroenterology Tags: Gastroenterology News Source Type: news
RBX2660 Shows Promise in Breaking the Cycle of Recurrent C diff RBX2660 Shows Promise in Breaking the Cycle of Recurrent C diff
Building on the success seen with fecal microbiota transplantation, this experimental treatment lowered the rates of recurrent C difficile infections.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - October 28, 2022 Category: Gastroenterology Tags: Gastroenterology News Source Type: news
Seres Therapeutics Announces FDA Acceptance of Biologics License Application for Investigational Microbiome Therapeutic SER-109 for Recurrent C. Difficile Infection for Priority Review
If approved, SER-109 expected to be the first-ever FDA-approved oral microbiome therapeutic
PDUFA target action date is April 26, 2023, with anticipated launch soon thereafter
FDA advised that they are not currently planning to hold an Advisory... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - October 26, 2022 Category: Drugs & Pharmacology Source Type: news
Early FMT Shows Promise for Preventing Recurrent C difficile Early FMT Shows Promise for Preventing Recurrent C difficile
The results of this trial suggest that microbiota restoration might be necessary to obtain sustained resolution following C difficile infection.MDedge News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 6, 2022 Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Powerful physics tool could help scientists understand complex ecosystems
Your gut is home to microbial madness. Hundreds of trillions of bacteria belonging to countless species interact with one another in complex ways that can both keep you healthy and
cause disease
. Teasing out these interactions would seem an impossible task.
Now, microbiologists have found help from an unlikely source: physics. A new experiment suggests a powerful concept known as a phase transition can predict how complex ecosystems—like those composed of the bacteria in your belly—behave. The finding could help us keep our guts healthy and even protect other complex ecosystems such as rainforests and ...
Source: ScienceNOW - October 6, 2022 Category: Science Source Type: news
Host and microbial-derived metabolites for Clostridioides difficile infection: Contributions, mechanisms and potential applications
Clostridioides difficile infection (CDI), which mostly occurs in hospitalized patients, is the most common and costly health care-associated disease. However, the biology of C. difficile remains incompletely understood. Current therapeutics are still challenged by the frequent recurrence of CDI. Advances in metabolomics facilitate our understanding of the etiology of CDI, which is not merely an alteration in the structure of the gut microbial community but also a dysbiosis metabolic setting promoting the germination, expansion and virulence of C. difficile. Therefore, we summarized the gut microbial and metabolic profiles ...
Source: Current Awareness Service for Health (CASH) - September 30, 2022 Category: Consumer Health News Source Type: news
Faecal microbiota transplantation for first or second Clostridioides difficile infection (EarlyFMT): a randomised, double-blind, placebo-controlled trial
Clostridioides difficile infection is an urgent antibiotic-associated health threat with few treatment options. Microbiota restoration with faecal microbiota transplantation is an effective treatment option for patients with multiple recurring episodes of C difficile. We compared the efficacy and safety of faecal microbiota transplantation compared with placebo after vancomycin for first or second C difficile infection. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 23, 2022 Category: Consumer Health News Source Type: news
FDA Advisors Back Fecal Microbiome Treatment for Recurrent C. Diff
(MedPage Today) -- An FDA advisory board recommended the agency approve a fecal microbiota transfer (FMT) product for recurrent Clostridium difficile infections.
By a vote of 13-4 on Thursday, the Vaccines and Related Biological Products Advisory... (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - September 23, 2022 Category: Gastroenterology Source Type: news
Fecal Microbiome Treatment for C. Diff to Face Scrutiny of FDA Panel
(MedPage Today) -- A Bayesian analysis will feature prominently in an FDA advisory board's decision whether to recommend approval of a fecal microbiota transfer (FMT) product for recurrent Clostridium difficile infections, and so may an imbalance... (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - September 21, 2022 Category: American Health Source Type: news
Clostridioides difficile: guidance, data and analysis, UKHSA (updated 20th September 2022)
The characteristics, diagnosis, management, surveillance and epidemiology of Clostridioides difficile (C. difficile).
20 September 2022Added open consultation on the guidance, treatment and management of Clostridioides difficile infection.
6 September 2019Replaced name Clostridium difficile with Clostridioides difficile to reflect changes in microbial taxonomy. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 20, 2022 Category: Consumer Health News Source Type: news
Hand hygiene among nurses in pediatric blood and marrow transplantation setting: a best practice implementation project
Background/purpose: Clostridium difficile infection (CDI) leads to a significant cause of hospital-acquired morbidity and mortality. Fecal microbiota transplantation (FMT) is effective to treat recurrent or refractory CDI (rCDI). However, the change of microbial composition contributed by FMT and its association with treatment outcomes is not well determined in Taiwan. We aimed to investigate the efficacy of FMT and the association with microbial alteration endemically.
Methods: Twelve patients who received FMT for rCDI in Taipei Veterans General Hospital were prospectively enrolled from April 2019 to July 2020. The clini...
Source: Current Awareness Service for Health (CASH) - September 20, 2022 Category: Consumer Health News Source Type: news
Alteration of gut microbial composition associated with the therapeutic efficacy of fecal microbiota transplantation in Clostridium difficile infection
Conclusion: Gut dysbiosis commonly co-exists in patients with rCDI. Restoration of gut microbial communities by FMT provides a promising strategy to treat antibiotic-failed CDI, and the extent of microbial change would be related to the treatment outcomes of FMT. Besides, the effectiveness of FMT for CDI could be maintained even the gut microbiota has diverged over time. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 20, 2022 Category: Consumer Health News Source Type: news
Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP | Science Signaling
Biological roles for c-di-AMP in C. difficile are revealed (Oberkampf et al., in 6 September 2022). (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 6, 2022 Category: Science Source Type: news
NHS patients struggling with superbugs to be offered poo transplants
Revolutionary treatment for C diff infections that transfers gut bacteria from healthy faeces given the green light by NiceHundreds of patients struggling to ward off superbugs are to be treated with poo transplants on the NHS using gut bacteria taken from healthy donors ’ faeces.The National Institute for Health and Care Excellence (Nice), the health regulator, has given the green light for a faecal microbiota transplant (FMT) to be offered to people who have been treated for two or more Clostridium difficile (C diff) infections without success.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - August 31, 2022 Category: Science Authors: Andrew Gregory Tags: Health NHS UK news Science National Institute for Health and Care Excellence Source Type: news
Faecal transplants recommended for Clostridium difficile
Clinical trials show they are more effective than antibiotics, to which the "superbug" can become resistant. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - August 31, 2022 Category: Consumer Health News Source Type: news
