A syndrome-based approach to antimicrobial stewardship in an Arizona skilled nursing facilityMoving the needle through quality improvement. American journal of infection control 48(12): 1537-1539
In 2015, an intervention to reduce unnecessary antibiotic prescribing for suspect urinary tract infection (UTI) was implemented in an Arizona skilled nursing facility. • Intervention included use of a 48[HYPHEN]hour enhanced observation protocol instead of urine culturing in low infection likelihood scenarios (eg, confusion without localizing signs of infection) and monthly feedback to providers on culturing and prescribing patterns. • In the 2 years following implementation of the intervention, antibiotic prescribing for suspect UTIs decreased by 85%, and C. difficile incidence by 86%, with no associated urosepsis eve...
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news
Using diagnostic stewardship to reduce rates, healthcare expenditures and accurately identify cases of hospital-onset Clostridioides difficile infection, Infection Control & Hospital Epidemiology 42(1): 51-56
Conclusions: Initiatives to decrease risk for CDI and diagnostic stewardship of C. difficile stool NAAT significantly reduced HO-HCFA CDI rates, detection of potential false-positives associated with laxative use, and lowered healt hcare costs. Diagnostic stewardship itself had the most dramatic impact on outcomes observed and served as an effective tool in reducing HO-HCFA CDI rates. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news
Clostridium difficile Infection Reservoirs Within an Acute Rehabilitation Environment, American Journal of Physical Medicine & Rehabilitation 100(1): 44-47
Conclusions: Nonsporicidal disinfectant was not effective on hospital floors. Sporicidal disinfection of the floor is important when rates of C difficile infection are increased. Wheelchairs are complex devices and difficult to properly clean. The hospital purchased an ultraviolent device for wheelchair cleaning with a subsequent reduction in spores on repeat cultures. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news
Cost Consequences for the NHS of Using a Two-Step Testing Method for the Detection of Clostridium difficile with a Point of Care, Polymerase Chain Reaction Test as the First Step
The two-step, POCT strategy was estimated to save £ 283,282 per 1000 hospitalized NHS patients with suspected infectious diarrhoea. Sensitivity analysis indicated that the turnaround time for the POCT was the largest driver for cost savings. Providing the POCT has sufficiently high diagnostic accuracy for detecting C. difficile, the two-step, POCT strategy for CDI identification is likely to be cost saving for NHS hospitals with an offsite laboratory. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 14, 2021 Category: Consumer Health News Source Type: news
An Analysis of Clostridium difficile Environmental Contamination During and After Treatment for C difficile Infection
There were significant reductions in C difficile recovery from both faeces and the environment around fidaxomicin versus vancomycin/metronidazole recipients. Therefore, fidaxomicin treatment may lower the C difficile transmission risk by reducing excretion and environmental contamination. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 14, 2021 Category: Consumer Health News Source Type: news
Study reveals new details about how bacterial toxins cause life-threatening colitis
FINDINGSResearch led by scientists from UCLA and Harvard University has uncovered details about how the bacterium Clostridioides difficile causes excessive inflammation in the gut that can lead to potentially deadly colitis. Studying C. difficile toxin A, one of two toxins released by the bacterium, the researchers produced two key findings.They pinpointed which part of the toxic protein can permeate cell membranes to gain entry to cellular structures called endosomes, demonstrating that even fragments of the protein that contain that key segment are capable of accessing endosomes.In addition, they revealed how the toxin m...
Source: UCLA Newsroom: Health Sciences - January 8, 2021 Category: Universities & Medical Training Source Type: news
Is C diff Clostridium difficile Contagious
How Do You Get C. diff (Clostridium difficile)? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - December 10, 2020 Category: General Medicine Source Type: news
UBCO researchers suggest stool transplants can battle serious infections
(University of British Columbia Okanagan campus) Could number two be number one when it comes to combating recurrent Clostridium difficile (CDI) infections? Using genetic material analysis and machine learning, UBC researchers have pinpointed several key factors to ensure successful fecal microbiota transplants (FMT), which have proven successful in treating bacterial infections in the gut including illnesses like C. difficile, Crohn's Disease, Colitis and even obesity, explains lead author Negin Kazemian. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 9, 2020 Category: International Medicine & Public Health Source Type: news
Comparing intervention strategies for reducing Clostridioides difficile transmission in acute healthcare settings: an agent-based modeling study
Conclusions: Overall, interventions that decrease patient susceptibility to colonization by C. difficile, such as antibiotic stewardship, were the most effective interventions in reducing both colonizations and CDI cases. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 18, 2020 Category: Consumer Health News Source Type: news
In your gut: How bacteria survive low oxygen environments
(Instituto de Tecnologia Qu í mica e Biol ó gica Ant ó nio Xavier da Universidade NOVA de Lisboa - ITQB NOV) Researchers from ITQB NOVA, in collaboration with the Institut Pasteur in Paris, have shed light on the mechanisms that allow Clostridioides difficile, a pathogen that can only grow in oxygen-free environments, to survive low oxygen levels. C. difficile is a major cause of intestinal problems associated with the use of antibiotics, causing an estimated number of 124k cases per year in the EU, costing on average 5k per patient, as a direct consequence of healthcare-associated contagion. (Source: EurekAlert! - I...
Source: EurekAlert! - Infectious and Emerging Diseases - November 2, 2020 Category: Infectious Diseases Source Type: news
Fecal Transplant Linked to Reduced C Difficile Mortality Fecal Transplant Linked to Reduced C Difficile Mortality
Vancomycin followed by fecal microbiota transplant was associated with reduced Clostridioides difficile (C diff)-related mortality in patients hospitalized with refractory severe or fulminant C diff.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - October 15, 2020 Category: Gastroenterology Tags: Gastroenterology News Source Type: news
C. difficile Linked to Surgery Risk in Pediatric Crohn's C. difficile Linked to Surgery Risk in Pediatric Crohn's
In pediatric Crohn ' s disease, a Clostridioides difficile infection detected within the first year after diagnosis is associated with a shorter time to first bowel resection surgery.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - October 15, 2020 Category: Gastroenterology Tags: Pediatrics News Source Type: news
Fecal Transplant Safe, Effective for C. Difficile Through Six Months
TUESDAY, Oct. 6, 2020 -- Fecal microbiota transplantation (FMT) is effective for Clostridium difficile infection (CDI) through six months and has a good safety profile, according to a study published online Oct. 1 in Gastroenterology.
Colleen R.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 6, 2020 Category: Pharmaceuticals Source Type: news
Real-World Safety, Efficacy Found for Fecal Transplants Real-World Safety, Efficacy Found for Fecal Transplants
Ninety percent of patients treated with fecal microbiota transplantation recovered from C. difficile infections, with few serious adverse events, a study of registry data found.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - October 2, 2020 Category: Gastroenterology Tags: Gastroenterology News Source Type: news
Reductions in Methicillin-resistant Staphylococcus aureus, Clostridium difficile Infection and Intensive Care Unit-Acquired Bloodstream Infection Across the United Kingdom Following Implementation of a National Infection Control Campaign
Methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile infections declined across the UK National Health Service in the decade that followed implementation of an infection control campaign. The national impact on intensive care unit (ICU)-acquired infections has not been documented. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 23, 2020 Category: Consumer Health News Source Type: news
