Antibacterial prophylaxis with fosfomycin at the time of the urethral catheter removal after radical prostatectomy (prospective randomized trial)
CONCLUSION: Antibacterial prophylaxis using two oral doses of fosfomycin 3 g on the day of urethral catheter removal and 48 hours after catheter removal after radical prostatectomy appears to be an effective scheme that reduces the incidence of urinary tract infection and the severity of lower urinary tract symptoms, and is characterized by a minimal risk of adverse events. It is necessary to carried out further research and develop clear recommendations for antibacterial prevention in urological interventions requiring prolonged urethral catheterization.PMID:38650404 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: I Veliev E A Sokolov E Yu Metelev A N Aliev E S Polyakova A V Ivkin E Source Type: research
Reduction of product composition variability using pooled microbiome ecosystem therapy and consequence in two infectious murine models
In this study, we compared the metagenomic profile of pooled products to corresponding single donor-derived products. We demonstrated that pooled products are more homogeneous, diverse, and enriched in beneficial bacteria known to produce anti-inflammatory short chain fatty acids compared to single donor-derived products. We then evaluated pooled products' efficacy compared to corresponding single donor-derived products in Salmonella and C. difficile infectious mouse models. We were able to demonstrate that pooled products decreased pathogenicity by inducing a structural change in the intestinal microbiota composition. Sin...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Julie Reygner Johanne Delannoy Marie-Th érèse Barba-Goudiaby Cyrielle Gasc Beno ît Levast Enora Gaschet Laurent Ferraris St éphane Paul Nathalie Kapel Anne-Judith Waligora-Dupriet Frederic Barbut Muriel Thomas Carole Schwintner Bastien Laperrousaz Nat Source Type: research
Reduction of product composition variability using pooled microbiome ecosystem therapy and consequence in two infectious murine models
In this study, we compared the metagenomic profile of pooled products to corresponding single donor-derived products. We demonstrated that pooled products are more homogeneous, diverse, and enriched in beneficial bacteria known to produce anti-inflammatory short chain fatty acids compared to single donor-derived products. We then evaluated pooled products' efficacy compared to corresponding single donor-derived products in Salmonella and C. difficile infectious mouse models. We were able to demonstrate that pooled products decreased pathogenicity by inducing a structural change in the intestinal microbiota composition. Sin...
Source: Applied and Environmental Microbiology - April 23, 2024 Category: Microbiology Authors: Julie Reygner Johanne Delannoy Marie-Th érèse Barba-Goudiaby Cyrielle Gasc Beno ît Levast Enora Gaschet Laurent Ferraris St éphane Paul Nathalie Kapel Anne-Judith Waligora-Dupriet Frederic Barbut Muriel Thomas Carole Schwintner Bastien Laperrousaz Nat Source Type: research
Impact of the coronavirus disease 2019 pandemic on the incidence of other infectious diseases in the hematology hospital in Korea
CONCLUSIONS: The implementation of COVID-19 infection control measures reduced the incidence of cRV infection. However, CDI increased significantly and incidence rates of CPE and VRE remained unchanged in hematological patients after the pandemic. Infection control measures suitable for each type of HCAI, such as stringent hand washing for CDI and enough isolation capacities, should be implemented and maintained in future pandemics, especially in immunocompromised patients.PMID:38649159 | DOI:10.3904/kjim.2023.508 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Seohee Oh Yu-Sun Sung Mihee Jang Yong-Jin Kim Hyun-Wook Park Dukhee Nho Dong-Gun Lee Hyeon Woo Yim Sung-Yeon Cho Source Type: research
Impact of the coronavirus disease 2019 pandemic on the incidence of other infectious diseases in the hematology hospital in Korea
CONCLUSIONS: The implementation of COVID-19 infection control measures reduced the incidence of cRV infection. However, CDI increased significantly and incidence rates of CPE and VRE remained unchanged in hematological patients after the pandemic. Infection control measures suitable for each type of HCAI, such as stringent hand washing for CDI and enough isolation capacities, should be implemented and maintained in future pandemics, especially in immunocompromised patients.PMID:38649159 | DOI:10.3904/kjim.2023.508 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 22, 2024 Category: Internal Medicine Authors: Seohee Oh Yu-Sun Sung Mihee Jang Yong-Jin Kim Hyun-Wook Park Dukhee Nho Dong-Gun Lee Hyeon Woo Yim Sung-Yeon Cho Source Type: research
The incidence of Clostridium difficile infection in children with and without inflammatory bowel diseases: A single-center study in Taiwan from 2006 to 2019
CONCLUSIONS: Both CA-CDI and healthcare facility-onset CDI (HO-CDI) were increasing substantially in the pediatric population over the past decade in Taiwan. Compared to the general pediatric population, pediatric IBD patients had a much higher incidence of CDI.PMID:38631957 | DOI:10.1016/j.jfma.2024.04.006 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 17, 2024 Category: General Medicine Authors: Mu-Ming Chien Mei-Hwei Chang Kai-Chi Chang Yen-Hsuan Ni Jia-Feng Wu Source Type: research
The incidence of Clostridium difficile infection in children with and without inflammatory bowel diseases: A single-center study in Taiwan from 2006 to 2019
CONCLUSIONS: Both CA-CDI and healthcare facility-onset CDI (HO-CDI) were increasing substantially in the pediatric population over the past decade in Taiwan. Compared to the general pediatric population, pediatric IBD patients had a much higher incidence of CDI.PMID:38631957 | DOI:10.1016/j.jfma.2024.04.006 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 17, 2024 Category: General Medicine Authors: Mu-Ming Chien Mei-Hwei Chang Kai-Chi Chang Yen-Hsuan Ni Jia-Feng Wu Source Type: research
C. difficile biomarkers, pathogenicity and detection
CONCLUSION: To overcome the deficiencies of conventional methods, the potential of advanced methods for C. difficile diagnosis, their direction, perspective, and challenges ahead were discussed.PMID:38621586 | DOI:10.1016/j.cca.2024.119674 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 15, 2024 Category: Chemistry Authors: Sepideh Ziaei Chamgordani Abbas Yadegar Hedayatollah Ghourchian Source Type: research
C. difficile biomarkers, pathogenicity and detection
CONCLUSION: To overcome the deficiencies of conventional methods, the potential of advanced methods for C. difficile diagnosis, their direction, perspective, and challenges ahead were discussed.PMID:38621586 | DOI:10.1016/j.cca.2024.119674 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 15, 2024 Category: Chemistry Authors: Sepideh Ziaei Chamgordani Abbas Yadegar Hedayatollah Ghourchian Source Type: research
C. difficile biomarkers, pathogenicity and detection
CONCLUSION: To overcome the deficiencies of conventional methods, the potential of advanced methods for C. difficile diagnosis, their direction, perspective, and challenges ahead were discussed.PMID:38621586 | DOI:10.1016/j.cca.2024.119674 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 15, 2024 Category: Chemistry Authors: Sepideh Ziaei Chamgordani Abbas Yadegar Hedayatollah Ghourchian Source Type: research
An ultrasensitive genosensor for detection of toxigenic and non-toxigenic Clostridioides difficile based on a conserved sequence in surface layer protein coding gene
Talanta. 2024 Apr 13;275:126014. doi: 10.1016/j.talanta.2024.126014. Online ahead of print.ABSTRACTClostridioides difficile (C. difficile) is the most common agent of antibiotic-associated diarrhea, leading to intestinal infection through the secretion of two major toxins. Not all strains of this bacterium are toxigenic, but some of them cause infection via their accessory virulence factors, such as surface layer protein (SlpA). SlpA is conserved in both toxigenic and non-toxigenic strains of C. difficile. In the present work, an amplification-free electrochemical genosensor was designed for the detection of the slpA gene....
Source: Talanta - April 14, 2024 Category: Chemistry Authors: Sepideh Ziaei Chamgordani Abbas Yadegar Masoumeh Azimirad Hedayatollah Ghourchian Source Type: research
Antibiotics-associated pseudomembranous colitis: a disproportionality analysis of the US food and drug administration adverse event reporting system (FAERS) database
CONCLUSIONS: This study was of great significance for healthcare professionals to realize the potential PMC risks of antibiotics.PMID:38603461 | DOI:10.1080/14740338.2024.2341813 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 11, 2024 Category: Drugs & Pharmacology Authors: Jinhua Chen Weijiang Yu Wancun Zhang Cuicui Sun Wenzhou Zhang Source Type: research
