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Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy?
Abstract Background/Aims: There has been no evidence for the necessity of endoscopy in asymptomatic young men with iron deficiency anemia (IDA). To determine whether endoscopy should be recommended in asymptomatic young men with IDA, we compared the prevalence of gastrointestinal (GI) lesions between young men (
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Kim NH, Park JH, Park DI, Sohn CI, Choi K, Jung YS Tags: Korean J Intern Med Source Type: research

Clinical features and prognoses of acute transverse myelitis in patients with systemic lupus erythematosus.
Conclusions: Higher disease activity in SLE and initial severe neurologic deficits might be associated with the poor outcome of ATM. Corticosteroid slowly tapering-off therapy might be helpful in preventing the recurrence of ATM. PMID: 29294596 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Ahn SM, Hong S, Lim DH, Ghang B, Kim YG, Lee CK, Yoo B Tags: Korean J Intern Med Source Type: research

MicroRNA-16 inhibits cell proliferation and migration by targeting heat shock protein 70 in heat-denatured dermal fibroblasts.
This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts. Methods: Primary human dermal fibroblasts were separated from normal human skin samples. Under heat stress, the levels of miR-16 and heat shock protein 70 (HSP70) were detected in primary human dermal fibroblasts by quantitative real-time polymerase chain reaction (qRT-PCR). Next, heat-denatured cells were transfected with synthetic scrambled negative control (NC) RNA (NC group), miR-16 mimics, miR-16 inhibitor or miR-16 inhibitor accompanied by small interfering RNA targeting HSP70, then th...
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Zhang C, Dai J, Fan Y, He X, Wei R Tags: Korean J Intern Med Source Type: research

Rapid onset of efficacy predicts response to therapy with certolizumab plus methotrexate in patients with active rheumatoid arthritis.
The objective of this study was to determine the efficacy and safety of add-on therapy with certolizumab pegol (CZP) in active rheumatoid arthritis (RA) patients of a single ethnicity. Methods: In this 24-week, phase 3, randomized, double-blind, placebo-controlled trial, eligible patients (n = 127) were randomized 2:1 to subcutaneous CZP + methotrexate (MTX; 400 mg at week 0, 2, and 4 followed by 200 mg every 2 weeks) or placebo + MTX. Results: At week 24, the American College of Rheumatology criteria for 20% (ACR20) response rate was significantly greater with CZP + MTX than with placebo (66.7% vs. 27.5%, p
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Kang YM, Park YE, Park W, Choe JY, Cho CS, Shim SC, Bae SC, Suh CH, Cha HS, Koh EM, Song YW, Yoo B, Lee SS, Park MC, Lee SH, Arendt C, Koetse W, Lee SK Tags: Korean J Intern Med Source Type: research

Transarterial embolization for incorrectable abdominal wall hematoma after abdominal paracentesis.
PMID: 29294599 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Moon SN Tags: Korean J Intern Med Source Type: research

Rapid changes in capillary morphology and architecture in a patient with dermatomyositis.
PMID: 29294600 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Park SJ, Choi IH, Kim HS Tags: Korean J Intern Med Source Type: research

Iatrogenic huge intracardiac air embolism during chest computed tomography.
PMID: 29294601 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Cho S, Lee H, Shin S, Park JK, Yoon SJ Tags: Korean J Intern Med Source Type: research

Sclerosing mesenteritis mimicking mesenteric malignancy.
PMID: 29294602 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Lee JY, Yun KJ, Kang DB, Kim TH, Chon HK Tags: Korean J Intern Med Source Type: research

The effect of the dexamethasone, cytarabine, and cisplatin (DHAP) regimen on stem cell mobilization and transplant outcomes of patients with non-Hodgkin's lymphoma who are candidates for up-front autologous stem cell transplantation.
Abstract Background/Aims: Data on dexamethasone, cytarabine, and cisplatin (DHAP) as a mobilization regimen, compared to high-dose cyclophosphamide (HDC), for up-front autologous stem cell transplantation (ASCT) in non-Hodgkin's lymphoma (NHL) is limited. Methods: Consecutive patients with aggressive NHL treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or rituximab-CHOP who underwent chemomobilization using HDC or DHAP plus granulocyte-colony stimulating factor (G-CSF) for up-front ASCT were enrolled from three institutions between 2004 and 2014. Results: Ninety-six patients...
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Jeon SY, Yhim HY, Kim HS, Kim JA, Yang DH, Kwak JY Tags: Korean J Intern Med Source Type: research

Ciliary metaplasia in a patient with antineutrophil cytoplasmic autoantibody-associated pauci-immune glomerulonephritis.
PMID: 29295613 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Lee CH, Lim JH, Kim KM, Park MH, Kang KP Tags: Korean J Intern Med Source Type: research

Management and educational status of adult anaphylaxis patients at emergency department.
Conclusions: We suggested that management and education of anaphylaxis were not fully carried out in ED. An education and promotion program on anaphylaxis is needed for medical staff. PMID: 29277095 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 28, 2017 Category: Internal Medicine Authors: Kim MY, Park CS, Jeong JW Tags: Korean J Intern Med Source Type: research

An overview of meta-analysis for clinicians.
Abstract The number of medical studies being published is increasing exponentially, and clinicians must routinely process large amounts of new information. Moreover, the results of individual studies are often insufficient to provide confident answers, as their results are not consistently reproducible. A meta-analysis is a statistical method for combining the results of different studies on the same topic and it may resolve conflicts among studies. Meta-analysis is being used increasingly and plays an important role in medical research. This review introduces the basic concepts, steps, advantages, and caveats of ...
Source: The Korean Journal of Internal Medicine - December 28, 2017 Category: Internal Medicine Authors: Lee YH Tags: Korean J Intern Med Source Type: research

Systemic review: agreement between the latent tuberculosis screening tests among patients with rheumatic diseases.
Conclusions: We reaffirm the current evidence for accuracy of LTBI test done by TST and IGRA among rheumatic patients is inconsistent. Our stratified analysis suggests different screening strategies might be needed in clinical settings considering the endemic status in the patient's country of origin and the precise nature of underlying diseases. PMID: 29277097 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 28, 2017 Category: Internal Medicine Authors: Pyo J, Cho SK, Kim D, Sung YK Tags: Korean J Intern Med Source Type: research

Body fluid status assessment by bio-impedance analysis in patients presenting to the emergency department with dyspnea.
Abstract Background/Aims: Fluid retention occurs in patients with heart failure, accounting for dyspnea. We investigated the diagnostic implication of body fluid status, assessed by bio-impedance analysis (BIA), in acute heart failure (AHF) among patients who presented with dyspnea. Methods: A total of 100 patients who presented with dyspnea and suspected with AHF were analyzed in this study. We enrolled 50 AHF and 50 non-AHF patients discriminated through echocardiographic analysis and Framingham criteria and were matched by age and sex. Body composition was analyzed using a multifrequency BIA. Results:...
Source: The Korean Journal of Internal Medicine - December 17, 2017 Category: Internal Medicine Authors: Park CS, Lee SE, Cho HJ, Kim YJ, Kang HJ, Oh BH, Lee HY Tags: Korean J Intern Med Source Type: research

Heart rate recovery and diastolic blood pressure ratio on the treadmill test predict an induction and recurrence of vasovagal syncope.
Conclusions: HRR/RecDBP may be a useful predictor for induction during HUT and recurrence during follow-up in the VVS. PMID: 29240992 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 15, 2017 Category: Internal Medicine Authors: Choi YJ, Kang KW, Jang SH, Kim JG, Lee SJ, Jung KT Tags: Korean J Intern Med Source Type: research

Usefulness of valacyclovir prophylaxis for cytomegalovirus infection after anti-thymocyte globulin as rejection therapy.
Abstract Background/Aims: Anti-thymocyte globulin (ATG) treatment for acute T-cell mediated rejection (TCMR) can increase the risk of cytomegalovirus (CMV) infection. We aimed to evaluate the effect of valacyclovir prophylaxis against CMV infection after ATG administration as anti-rejection therapy. Methods: We retrospectively analyzed 55 kidney transplant recipients (KTRs) receiving ATG for steroid resistant TCMR. In all KTRs, we used intravenous ganciclovir during ATG injection. In 34 KTRs treated before July 2013, we performed preemptive therapy for CMV infection after ATG therapy. They were regarded as th...
Source: The Korean Journal of Internal Medicine - December 15, 2017 Category: Internal Medicine Authors: Ko EJ, Yu JH, Yang CW, Chung BH Tags: Korean J Intern Med Source Type: research

Combination of carboplatin and intermittent normobaric hyperoxia synergistically suppresses benzo[a]pyrene-induced lung cancer.
Conclusions: Intermittent normobaric hyperoxia was found to be tumoricidal and thus may serve as an adjuvant therapy for lung cancer. Oxidative stress and its effects on DNA are increased following exposure to hyperoxia and even more with chemotherapy, and this may lead to apoptosis of lung tumors. PMID: 29237253 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 15, 2017 Category: Internal Medicine Authors: Lee HY, Kim IK, Lee HI, Lee HY, Kang HS, Yeo CD, Kang HH, Moon HS, Lee SH Tags: Korean J Intern Med Source Type: research

Factors associated with time to diagnosis from symptom onset in patients with early rheumatoid arthritis.
Abstract Background/Aims: To identify the factors associated with time to diagnosis after symptom onset in patients with early rheumatoid arthritis (RA). Methods: Early RA patients with ≤ 1 year of disease duration in the KORean Observational study Network for Arthritis (KORONA) database were included in this analysis. Patients were further divided into two groups according to the time to diagnosis from symptom onset: the early diagnosis group (time to diagnosis ≤ 1 year) and the late diagnosis group (time to diagnosis> 1 year). Using the multivariable regression model, we identified factors associat...
Source: The Korean Journal of Internal Medicine - December 14, 2017 Category: Internal Medicine Authors: Cho SK, Kim D, Won S, Lee J, Choi CB, Choe JY, Hong SJ, Jun JB, Kim TH, Koh E, Lee HS, Lee J, Yoo DH, Yoon BY, Bae SC, Sung YK, Korean Observational Study Network for Arthritis (KORONA) Investigators Tags: Korean J Intern Med Source Type: research

Clinical and economic analysis of the 2009 H1N1 influenza pandemic among pregnant Korean women.
Conclusions: Although statistically insignificant, the detrimental impact of influenza A H1N1pdm09 on pregnancy can be serious in some complicated cases in South Korea. Thus, the strong recommendation of influenza vaccination should be maintained for pregnant women as a high priority. PMID: 29232939 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 14, 2017 Category: Internal Medicine Authors: Choi WS, Choi MJ, Noh JY, Song JY, Kim WJ, Park DW, Lee J, Seo YB, Baek JH, Choi S, Cheong HJ Tags: Korean J Intern Med Source Type: research

No benefit of hypomethylating agents compared to supportive care for higher risk myelodysplastic syndrome.
This study evaluated the role of hypomethylating agents (HMA) compared to best supportive care (BSC) for patients with high or very-high (H/VH) risk myelodysplastic syndrome (MDS) according to the Revised International Prognostic Scoring System. Methods: A total of 279 H/VH risk MDS patients registered in the Korean MDS Working Party database were retrospectively analyzed. Results: HMA therapy was administered to 205 patients (73.5%), including 31 patients (11.1%) who then received allogeneic hematopoietic cell transplantation (allo-HCT), while 74 patients (26.5%) received BSC or allo-HCT without HMA. The 3-year ...
Source: The Korean Journal of Internal Medicine - December 14, 2017 Category: Internal Medicine Authors: Sohn SK, Moon JH, Lee IH, Ahn JS, Kim HJ, Chung JS, Shin HJ, Park SW, Lee WS, Lee SM, Kim H, Lee HS, Kim YS, Cho YY, Bae SH, Lee JH, Kim SH, Song IC, Kwon JH, Lee YJ Tags: Korean J Intern Med Source Type: research

Korean rheumatology workforce from 1992 to 2015: current status and future demand.
Conclusions: Because of the uneven distribution of rheumatologists, it is likely that some patients with chronic rheumatic conditions have limited access to rheumatology care. Thus, a policy-based approach is needed to alleviate this disparity. PMID: 29232941 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 14, 2017 Category: Internal Medicine Authors: Lee CU, Kim JN, Kim JW, Park SH, Lee H, Kim SK, Choe JY Tags: Korean J Intern Med Source Type: research

Predictors for the need for endoscopic therapy in patients with presumed acute upper gastrointestinal bleeding.
This study assessed easily applicable factors to predict cases in need of urgent endoscopic hemostasis due to acute upper gastrointestinal bleeding. Methods: The consecutively included patients were divided into the endoscopic hemostasis and nonendoscopic hemostasis groups. We reviewed the enrolled patients' medical records and analyzed various variables and parameters for acute upper gastrointestinal bleeding outcomes such as demographic factors, comorbidities, symptoms, signs, laboratory findings, rebleeding rate, and mortality to evaluate simple predictive factors for endoscopic treatment. Results: A total of ...
Source: The Korean Journal of Internal Medicine - December 14, 2017 Category: Internal Medicine Authors: Kim SS, Kim KU, Kim SJ, Seo SI, Kim HS, Jang MK, Kim HY, Shin WG Tags: Korean J Intern Med Source Type: research

Effect of Helicobacter pylori eradication on the regression of gastric polyps in National Cancer Screening Program.
Conclusions: Eradication of H. pylori infection may induce disappearance of gastric hyperplastic polyps in National Cancer Screening Cohort. PMID: 29232943 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 14, 2017 Category: Internal Medicine Authors: Nam SY, Park BJ, Ryu KH, Nam JH Tags: Korean J Intern Med Source Type: research

The effects of addition of coenzyme Q10 to metformin on sirolimus-induced diabetes mellitus.
Conclusions: Addition of CoQ10 to MET has a beneficial effect on SRL-induced DM compared to MET alone. PMID: 29228766 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 13, 2017 Category: Internal Medicine Authors: Sun IO, Jin L, Jin J, Lim SW, Chung BH, Yang CW Tags: Korean J Intern Med Source Type: research

Novel treatments for inflammatory bowel disease.
Abstract Increased understanding of the immunopathology of inflammatory bowel disease (IBD) has led to the development of targeted therapies and has unlocked a new era in IBD treatment. The development of treatment options aimed at a variety of pathological mechanisms offers new hope for customized therapies. Beyond anti-tumor necrosis factor agents, selective lymphocyte trafficking inhibitors have been proposed as potent drugs for IBD. Among these, vedolizumab has recently been approved for both Crohn's disease and ulcerative colitis. Numerous other agents for IBD treatment are currently under investigation, incl...
Source: The Korean Journal of Internal Medicine - December 11, 2017 Category: Internal Medicine Authors: Lee HS, Park SK, Park DI Tags: Korean J Intern Med Source Type: research

Updated treatment strategies for intestinal Beh ├žet's disease.
Updated treatment strategies for intestinal Behçet's disease. Korean J Intern Med. 2017 Dec 08;: Authors: Park YE, Cheon JH Abstract Behçet's disease (BD) is a chronic, idiopathic, relapsing immune-mediated disease involving multiple organs, and is characterized by recurrent oral and genital ulcers, ocular disease, gastrointestinal ulcers, vascular diseases, and skin lesions. In particular, gastrointestinal involvement in BD is followed by severe complications, including massive bleeding, bowel perforation, and fistula, which can lead to significant morbidity and mortality. However, the ...
Source: The Korean Journal of Internal Medicine - December 8, 2017 Category: Internal Medicine Authors: Park YE, Cheon JH Tags: Korean J Intern Med Source Type: research

Unexpected amyloidosis, mimicking a splenic cyst.
PMID: 29207868 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 7, 2017 Category: Internal Medicine Authors: Chang CF, Liao YS, Chen YG, Ye RH Tags: Korean J Intern Med Source Type: research

Concomitant emphysematous cystitis and liver abscess.
PMID: 29207869 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - December 7, 2017 Category: Internal Medicine Authors: Lai CC Tags: Korean J Intern Med Source Type: research

Non-alcoholic fatty liver disease and lifestyle modifications, focusing on physical activity.
Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and the prevalence of non-alcoholic steatohepatitis (NASH) with fibrosis is increasing as the population with NAFLD ages. To date, lifestyle modifications including weight loss, increased physical activity, and dietary changes remain the treatment of choice for NAFLD because there are no approved effective pharmacologic agents. Increased physical activity has therapeutic effects on NAFLD by reducing hepatic fat independent of weight reduction. Indeed, even minimal physical activity below the recommended threshold may have ...
Source: The Korean Journal of Internal Medicine - December 6, 2017 Category: Internal Medicine Authors: Kwak MS, Kim D Tags: Korean J Intern Med Source Type: research

The evaluation of cellular immune function in elderly patients with systemic lupus erythematosus.
Conclusions: The significantly lower CD4+ /CD8+ ratio among SLE patients over 60 years old is associated with deregulated immune responses and the development of SLE. A low ANA titer (1:160) is common in healthy elders, emphasizing the importance of considering age when determining if the evaluation of ANA titers is to be included in autoimmune disease diagnosis. PMID: 29172398 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 28, 2017 Category: Internal Medicine Authors: Men K, Chen Y, Zhang J, Wei D Tags: Korean J Intern Med Source Type: research

Development, validation, and application of a novel tool to measure disease-related knowledge in patients with inflammatory bowel disease.
Abstract Background/Aims: The Crohn's and Colitis Knowledge (CCKNOW) score does not reflect updated knowledge relating to inflammatory bowel disease (IBD). The aim of this study was to develop, validate, and apply a novel tool to measure disease-related knowledge in IBD patients. Methods: A questionnaire composed of 24 items regarding knowledge of IBD was developed: Inflammatory Bowel Disease Knowledge (IBD-KNOW). Discriminate ability of IBD-KNOW was validated in three occupational groups (14 doctors, 20 nurses, and 19 clerks). The CCKNOW and IBD-KNOW were administered to IBD patients. Factors affecting the l...
Source: The Korean Journal of Internal Medicine - November 28, 2017 Category: Internal Medicine Authors: Yoon H, Yang SK, So H, Lee KE, Park SH, Jung SA, Choh JH, Shin CM, Park YS, Kim N, Lee DH Tags: Korean J Intern Med Source Type: research

Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease.
Conclusions: Our results indicated that circulating renalase might be a predictor of mortality and adverse renal outcomes in patients with CKD. PMID: 29172403 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 28, 2017 Category: Internal Medicine Authors: Baek SH, Cha RH, Kang SW, Park CW, Cha DR, Kim SG, Yoon SA, Kim S, Han SY, Park JH, Chang JH, Lim CS, Kim YS, Na KY Tags: Korean J Intern Med Source Type: research

Risk of malignancy in patients with rheumatoid arthritis after anti-tumor necrosis factor therapy: results from Korean National Health Insurance claims data.
Conclusions: This study revealed that cancer incidence was similar in RA patients treated with TNFi and csDMARDs. Anti-TNF therapy may be a safe therapeutic option for RA treatment, in terms of malignancy. PMID: 29172405 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 28, 2017 Category: Internal Medicine Authors: Jung SM, Kwok SK, Ju JH, Park YB, Park SH Tags: Korean J Intern Med Source Type: research

A novel neurofibromatosis type 1 (NF1) mutation in a patient with NF1 and pheochromocytoma.
PMID: 29172408 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 28, 2017 Category: Internal Medicine Authors: Seo Y, Jeong Y, Kim DY, Choi K, Kim ES, Moon SD, Han JH Tags: Korean J Intern Med Source Type: research

The impact of primary tumor location in patients with metastatic colorectal cancer: a Korean Cancer Study Group CO12-04 study.
Abstract Background/Aims: Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC). Methods: Demographic data and clinical information were collected from 1,115 patients from the Republic of Korea, who presented with mCRC between January 2009 and December 2011, using web-based electronic case report forms. Associations between the primary tumor location and the patient's clinical characteristics were assessed, and factors inf luencing overall survival were ana...
Source: The Korean Journal of Internal Medicine - November 28, 2017 Category: Internal Medicine Authors: Byun JH, Ahn JB, Kim SY, Kang JH, Zang DY, Kang SY, Kang MJ, Shim BY, Baek SK, Kim BS, Lee KH, Lee SI, Cho SH, Sohn BS, Kim S, Hwang IG, Nam EM, Seo BG, Oh SC, Lee MA, Lee SC, Hong JH, Park YS Tags: Korean J Intern Med Source Type: research

Methylprednisolone versus intravenous immune globulin as an initial therapy in adult primary immune thrombocytopenia.
Conclusions: These results indicate that neither the early response rate nor the long-term outcome differed between the methyl-Pd and IVIg treatments. However, IVIg induced a complete response more rapidly than did methyl-Pd. PMID: 29172399 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 27, 2017 Category: Internal Medicine Authors: Kim CH, Choi YS, Moon JY, Kim DY, Lee SY, Lee HJ, Yun HJ, Kim S, Jo DY, Song IC Tags: Korean J Intern Med Source Type: research

Management of carbapenem-resistant Acinetobacter baumannii epidemic in an intensive care unit using multifaceted intervention strategy.
This study was conducted in a medical ICU between April 2012 and June 2016. The baseline infection control programs included surveillance cultures, contact precautions, and environmental cleaning. However, increases in the detection of CRAB isolates beginning in May 2013 led to the implementation of a new protocol, consisting of universal glove and gown use with daily chlorhexidine bathing for all patients in combination with baseline programs. The efficacy of the intervention was subjected to interrupted time series (ITS) analysis. Results: The multifaceted intervention led to a decrease in the incidence of CRAB from...
Source: The Korean Journal of Internal Medicine - November 27, 2017 Category: Internal Medicine Authors: Hong J, Jang OJ, Bak MH, Baek EH, Park KH, Hong SI, Cho OH, Bae IG Tags: Korean J Intern Med Source Type: research

Olmesartan is not associated with the risk of enteropathy: a Korean nationwide observational cohort study.
Conclusions: Olmesartan was not associated with intestinal malabsorption or significant body weight loss in the general Korean population. Additional large-scale prospective studies of the relationship between olmesartan and the incidence of enteropathy in the Asian population are needed. PMID: 29172402 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 27, 2017 Category: Internal Medicine Authors: You SC, Park H, Yoon D, Park S, Joung B, Park RW Tags: Korean J Intern Med Source Type: research

Small RNA sequencing profiles of mir-181 and mir-221, the most relevant microRNAs in acute myeloid leukemia.
Conclusions: Our results demonstrate that mir-221 and mir-181 are selectively enriched in AML marrow and reflect disease activity. mir-3154 is a novel microRNA that is relevant to AML but needs further validation. PMID: 29172404 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 27, 2017 Category: Internal Medicine Authors: Lee YG, Kim I, Oh S, Shin DY, Koh Y, Lee KW Tags: Korean J Intern Med Source Type: research

The impact of sarcopenia on health-related quality of life in elderly people: Korean National Health and Nutrition Examination Survey.
Conclusions: There is a significant association between sarcopenia and impaired health-related quality of life in this elderly Korean population, and these results differ between men and women. PMID: 29172406 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 27, 2017 Category: Internal Medicine Authors: Sun S, Lee H, Yim HW, Won HS, Ko YH Tags: Korean J Intern Med Source Type: research

Clinical significance of anti-dense fine speckled 70 antibody in patients with fibromyalgia.
Conclusions: Anti-DFS70 antibodies may represent a useful biomarker for differentiating between FM and other autoimmune diseases. The levels of anti-DFS70 antibodies were also significantly higher among patients with arthralgia and sleep disturbances. Further investigations are necessary to evaluate the relationships between anti-DFS70 antibodies and other cytokines as a predictive marker for pain. PMID: 29166758 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 24, 2017 Category: Internal Medicine Authors: Jeong J, Kim DH, Park G, Park S, Kim HS Tags: Korean J Intern Med Source Type: research

Magnetic resonance imaging-assessed synovial and bone changes in hand and wrist joints of rheumatoid arthritis patients.
Conclusions: This study identified the distribution and prevalence of MRI-detected bone erosion, BME, synovitis, and tenosynovitis of the wrist and MCP joints in RA patients. The patterns of the MRI-detected abnormalities may help to select sites for the application of MRI protocols in clinical trials and practice. PMID: 29166759 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 24, 2017 Category: Internal Medicine Authors: Lee KA, Min SH, Kim TH, Lee SH, Kim HR Tags: Korean J Intern Med Source Type: research

Clinical characteristics and treatment propensity in elderly patients aged over 80 years with colorectal cancer.
Conclusions: Elderly patients aged ≥ 80 years with CRC tended to receive less treatment for metastatic disease. Nevertheless, anticancer treatment in patients with favorable PS was effective in prolonging OS regardless of disease extent. PMID: 29166760 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 24, 2017 Category: Internal Medicine Authors: Jung YH, Kim JY, Jang YN, Yoo SH, Kim GH, Lee KM, Lee IK, Chung SM, Woo IS Tags: Korean J Intern Med Source Type: research

Full-blown hyperparathyroidism.
PMID: 29166761 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 24, 2017 Category: Internal Medicine Authors: Bae WK, Chung IJ Tags: Korean J Intern Med Source Type: research

Present status and perspectives of endosonography 2017 in gastroenterology.
Abstract Endoscopic ultrasound has become an essential tool in modern gastroenterology and abdominal surgery. Compared with all other endoscopic methods, it has the most potential for innovation and its future looks bright. Thus, we compiled this summary of established and novel applications of endoscopic ultrasound methods to inform the reader about what is already possible and where future developments will lead in improving patient care further. This review is structured in four parts. The first section reports on developments in diagnostic endoscopic ultrasound, the second looks at semi-invasive endoscopic ult...
Source: The Korean Journal of Internal Medicine - November 23, 2017 Category: Internal Medicine Authors: Hocke M, Braden B, Jenssen C, Dietrich CF Tags: Korean J Intern Med Source Type: research

Impact of sarcopenia on long-term mortality and cardiovascular events in patients undergoing hemodialysis.
Conclusions: Sarcopenia was strongly associated with long-term mortality and cardiovascular events in HD patients. Assessment of muscle strength and muscle mass may provide additional prognostic information to survival in patients with end-stage renal disease. PMID: 29161801 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 23, 2017 Category: Internal Medicine Authors: Kim JK, Kim SG, Oh JE, Lee YK, Noh JW, Kim HJ, Song YR Tags: Korean J Intern Med Source Type: research

Association between initial vascular access and survival in hemodialysis according to age.
This study aims to demonstrate whether the association between initial vascular access and mortality among hemodialysis patients varies by age. Methods: We conducted a retrospective study that included 2,552 patients who started hemodialysis. Vascular access was divided into three categories: percutaneous catheter, tunneled cuffed catheter, and arteriovenous (AV) access. Results: Survival rates for patients who received a central venous catheter, such as percutaneous or tunneled cuffed catheter, aged 65 to 74 years and those ≥ 75 years were reduced, but not for those aged
Source: The Korean Journal of Internal Medicine - November 20, 2017 Category: Internal Medicine Authors: Kim HY, Bae EH, Ma SK, Kim SW Tags: Korean J Intern Med Source Type: research

Clinical features of snoring patients during sedative endoscopy.
Conclusions: Patients who snore during sedative endoscopy may need to be evaluated for possible coronary artery disease. PMID: 29132198 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 15, 2017 Category: Internal Medicine Authors: Chung JW, Kim N, Wee JH, Lee J, Lee J, Kwon S, Hwang YJ, Yoon H, Shin CM, Park YS, Lee DH, Kim JW Tags: Korean J Intern Med Source Type: research

Non-fasting triglyceride levels in the Korean population with and without ischemic heart disease and cerebrovascular disease.
Abstract Background/Aims: Associations between non-fasting triglyceride (TG) levels and a risk of ischemic heart disease (IHD) and cerebrovascular accident (CVA) have been suggested in Caucasians. We aimed to investigate whether non-fasting TG levels reflect the risk of IHD/CVA in Koreans. Methods: We conducted an analysis of patients aged ≥ 30 years from the nationwide survey database. Fasting TG was defined as a measurement taken ≥ 12 hours since the last meal. Non-fasting TG was categorized by fasting duration of 0 to 3, 4 to 7, and 8 to 11 hours. Results: In subjects without history of IHD/CVA,...
Source: The Korean Journal of Internal Medicine - November 15, 2017 Category: Internal Medicine Authors: Lee SY, Koo BK, Moon MK Tags: Korean J Intern Med Source Type: research

Expression and prognostic significance of microRNAs in Korean patients with myelodysplastic syndrome.
Conclusions: Although our study was limited by the relatively small number of patients included, we identified several miRNAs associated with pathogenesis, leukemic transformation, and prognosis in MDS. PMID: 29132200 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 15, 2017 Category: Internal Medicine Authors: Choi Y, Hur EH, Moon JH, Goo BK, Choi DR, Lee JH Tags: Korean J Intern Med Source Type: research