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Recent advances in the diagnosis and management of primary myelofibrosis.
Abstract Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) in which dysregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathways is the major pathogenic mechanism. Most patients with PMF carry a driver mutation in the JAK2, MPL (myeloproliferative leukemia), or CALR (calreticulin) genes. Mutations in epigenetic regulators and RNA splicing genes may also occur, and play critical roles in PMF disease progression. Based on revised World Health Organization diagnostic criteria for MPNs, both screening for driver mutations and bone marrow biopsy are...
Source: The Korean Journal of Internal Medicine - April 20, 2018 Category: Internal Medicine Authors: Takenaka K, Shimoda K, Akashi K Tags: Korean J Intern Med Source Type: research

Effect of the anti-IL-17 antibody on allergic inflammation in an obesity-related asthma model.
Conclusions: These results suggest that the IL-17-leptin/adiponectin axis plays a key role in airway inflammation in obesity-related asthma. Our findings suggest a potential new treatment for IL-17 as a target that may benefit obesity-related asthma patients who respond poorly to typical asthma medications. PMID: 29665658 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 19, 2018 Category: Internal Medicine Authors: Liang L, Hur J, Kang JY, Rhee CK, Kim YK, Lee SY Tags: Korean J Intern Med Source Type: research

How to tackle congestion in acute heart failure.
Abstract Acute heart failure is a common complication of chronic heart failure and is associated with a high risk for subsequent mortality and morbidity. In 90% of case acute heart failure is the resultant of congestion, a manifestation of fluid build-up due to increased filling pressures. As residual congestion at discharge following an acute heart failure episodes is one of the strongest predictors of poor outcome, the goal of therapy should be to resolve congestion completely. Important to comprehend is that increased cardiovascular filling pressures are not solely the resultant of intravascular volume excess b...
Source: The Korean Journal of Internal Medicine - April 10, 2018 Category: Internal Medicine Authors: Martens P, Mullens W Tags: Korean J Intern Med Source Type: research

Experiences of magnetic resonance imaging scanning in patients with pacemakers or implantable cardioverter-defibrillators.
Conclusions: This single-center retrospective study found that MRI can be performed safely in patients with pacemakers or implantable cardioverter defibrillators, regardless of the MRI support, as long as appropriate precautions are taken. PMID: 29609452 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 4, 2018 Category: Internal Medicine Authors: Han D, Kang SH, Cho Y, Oh IY Tags: Korean J Intern Med Source Type: research

Korean physicians' policies for postoperative surveillance of colorectal cancer.
Conclusions: Korean physicians mostly followed up CRC using intensive postoperative surveillance. In preference to monitoring over a comparatively shorter period of time, the physicians tended to prefer monitoring patients post-operatively over a> 5 year period, particularly in cases of advanced-stage CRC. PMID: 29609453 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 4, 2018 Category: Internal Medicine Authors: Baek SK, Lee SC, Kim JG, Um JW, Lee SH, Jang BI, Park JJ, Kim TW Tags: Korean J Intern Med Source Type: research

Pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure.
Conclusions: Pre-discharge anemia, rather than anemia at admission, was identified as an independent predictor of mortality in patients with ADHF after surviving discharge. The results of the present study suggest that the identification and optimal management of anemia during hospitalization are important in patients with ADHF. PMID: 29562736 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 23, 2018 Category: Internal Medicine Authors: Kim MC, Kim KH, Cho JY, Lee KH, Sim DS, Yoon HJ, Yoon NS, Hong YJ, Park HW, Kim JH, Ahn Y, Jeong MH, Cho JG, Park JC Tags: Korean J Intern Med Source Type: research

Percutaneous coronary intervention in patients with multi-vessel coronary artery disease: a focus on physiology.
Abstract Multi-vessel coronary artery disease (MVD) frequently features ambiguous or intermediate lesions that may be both serial and complex, suggesting that multiple regions require revascularization. Percutaneous coronary intervention (PCI) is associated with various challenges such as appropriate identification of lesions that should be treated, the choice of an optimum revascularization method, and limitations of long-term outcomes. Optimal patient selection and careful targeting of lesions are key when planning treatment. Physiology-guided decision-making (based on the fractional flow reserve) can overcome t...
Source: The Korean Journal of Internal Medicine - March 21, 2018 Category: Internal Medicine Authors: Cho YK, Nam CW Tags: Korean J Intern Med Source Type: research

Treatment patterns of knee osteoarthritis patients in Korea.
Abstract Background/Aims: To evaluate the treatment patterns of knee osteoarthritis (OA) patients in South Korea. Methods: Using the Korean nationwide claims database, all knee OA patients in Korea during 2014 were identified by the knee OA diagnostic code (M17) or any OA diagnostic code (M15 to M19) in combination with a procedure for a knee X-ray. Patterns of medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids (CSs), analgesics, and symptomatic slow acting drugs for OA (SYSADOA) were analyzed. Prevalence and characteristics of knee OA patients who received a CS intra-articular...
Source: The Korean Journal of Internal Medicine - March 21, 2018 Category: Internal Medicine Authors: Park HR, Cho SK, Im SG, Jung SY, Kim D, Jang EJ, Sung YK Tags: Korean J Intern Med Source Type: research

Validation of the Friedewald formula for estimating low density lipoprotein cholesterol: the Korea National Health and Nutrition Examination Survey, 2009 to 2011.
Abstract Background/Aims: The aim of this study is to compare Friedewald-estimated and directly measured low density lipoprotein cholesterol (LDL-C) values and assess the concordance in guideline risk classification between the two methods. Methods: The data were derived from the 2009 to 2011 Korea National Health and Nutrition Examination Survey. We included subjects with triglyceride (TG) levels
Source: The Korean Journal of Internal Medicine - March 21, 2018 Category: Internal Medicine Authors: Lee J, Jang S, Jeong H, Ryu OH Tags: Korean J Intern Med Source Type: research

Expanding transcatheter aortic valve replacement into uncharted indications.
Abstract Since the first-in-man transcatheter delivery of an aortic valve prosthesis in 2002, the landscape of aortic stenosis therapeutics has shifted dramatically. While initially restricted to non-surgical cases, progressive advances in transcatheter aortic valve replacement and our understanding of its safety and efficacy have expanded its use in intermediate and possibly low surgical risk patients. In this review, we explore the past, present, and future of transcatheter aortic valve replacement. PMID: 29551053 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 20, 2018 Category: Internal Medicine Authors: Kang G, Kim JB Tags: Korean J Intern Med Source Type: research

Ezetimibe decreased nonalcoholic fatty liver disease activity score but not hepatic steatosis.
Conclusions: Ezetimibe decreased NAS without improving hepatic steatosis. PMID: 29551054 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 20, 2018 Category: Internal Medicine Authors: Lee HY, Jun DW, Kim HJ, Oh H, Saeed WK, Ahn H, Cheung RC, Nguyen MH Tags: Korean J Intern Med Source Type: research

A score for decision making during percutaneous coronary intervention in acute myocardial infarction patients with multivessel disease.
Conclusions: The results suggest that patients with a CONVERSE score of 3 or more should undergo MV PCI. PMID: 29551055 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 20, 2018 Category: Internal Medicine Authors: Jeong HC, Ahn JH, Kim MC, Sim DS, Park KH, Hong YJ, Kim JH, Jeong MH, Seung KB, Chang K, Ahn Y Tags: Korean J Intern Med Source Type: research

Update of aristolochic acid nephropathy in Korea.
Conclusions: Our report shows that patients were still exposed to AA-containing herbal medicine and that there is a possibility of underdiagnosis of AAN in Korea. A stronger national supervision system of herbal ingredients and remedies in oriental medicine is needed to prevent AAN. PMID: 29551056 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 20, 2018 Category: Internal Medicine Authors: Ban TH, Min JW, Seo C, Kim DR, Lee YH, Chung BH, Jeong KH, Lee JW, Kim BS, Lee SH, Choi BS, Han JS, Yang CW Tags: Korean J Intern Med Source Type: research

Paget disease in a radius.
PMID: 29551057 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 19, 2018 Category: Internal Medicine Authors: Zhang R, Zhang G, Wang R, Jia Q, Tan J Tags: Korean J Intern Med Source Type: research

Gender difference in the association between brachial-ankle pulse wave velocity and cardiovascular risk scores.
This study investigated the relationship between baPWV and four different cardiovascular risk-predicting scores in men and women. Methods: A total of 539 subjects (58.1 ± 12.2 years, 50.1% men) without cardiovascular disease (CVD) who underwent health examinations including baPWV measurement were retrospectively analyzed. Four cardiovascular risk scores (Framingham risk score [FRS; 1998], Adult Treatment Panel [ATP] III revised FRS [2002], generalized FRS [2008], and American College of Cardiology/American Heart Association [ACC/AHA] CVD risk [2013]) were calculated in each subject. Results: In a total pop...
Source: The Korean Journal of Internal Medicine - March 16, 2018 Category: Internal Medicine Authors: Rhee TM, Kim HL, Oh S, Lim WH, Seo JB, Chung WY, Kim SH, Kim MA, Zo JH Tags: Korean J Intern Med Source Type: research

The effect of metformin on culture conversion in tuberculosis patients with diabetes mellitus.
Conclusions: Among cavitary pulmonary TB patients with DM, metformin can be an effective adjunctive anti-TB agent to improve sputum culture conversion after 2 months of treatment. PMID: 29540054 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 16, 2018 Category: Internal Medicine Authors: Lee YJ, Han SK, Park JH, Lee JK, Kim DK, Chung HS, Heo EY Tags: Korean J Intern Med Source Type: research

Clinical activity of fulvestrant in metastatic breast cancer previously treated with endocrine therapy and/or chemotherapy.
Conclusions: Fulvestrant showed encouraging clinical activity and favorable feasibility in postmenopausal women with MBC who had been treated with multiple endocrine therapies and/or cytotoxic chemotherapies. PMID: 29540055 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 16, 2018 Category: Internal Medicine Authors: Heo MH, Kim HK, Lee H, Kim JY, Ahn JS, Im YH, Park YH Tags: Korean J Intern Med Source Type: research

Platelet count is associated with sustained virological response rates in treatments for chronic hepatitis C.
This study was conducted to clarify the sustained virological response (SVR) prediction ability of baseline and treatment-related factors in patients with chronic hepatitis C virus (HCV) infection. Methods: This retrospective study collected data at four tertiary referral hospitals between June 2004 and July 2012. Out of 476 patients, 330 treatment-naïve patients with chronic HCV infection were recruited. Pegylated interferon α-2a/- 2b plus ribavirin was administered for either 24 or 48 weeks depending on the HCV genotype. The baseline and treatment-related predictive factors of SVR were evaluated by analyz...
Source: The Korean Journal of Internal Medicine - March 14, 2018 Category: Internal Medicine Authors: Jun BG, Park EJ, Lee WC, Jang JY, Jeong SW, Kim YD, Cheon GJ, Cho YS, Lee SH, Kim HS, Lee YN, Kim SG, Kim YS, Kim BS Tags: Korean J Intern Med Source Type: research

Outcome of donor biliary complications following living donor liver transplantation.
Conclusions: All donors with biliary complications were successfully treated non-surgically, with most improving after endoscopic placement of endobiliary stents and none showing recurrence on long term follow-up. PMID: 29529841 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 14, 2018 Category: Internal Medicine Authors: Woo HY, Lee IS, Chang JH, Youn SB, Bae SH, Choi JY, Chun HJ, You YK, Kim DG, Yoon SK Tags: Korean J Intern Med Source Type: research

Risk factors for hypothyroidism in euthyroid thyroid nodule patients with lymphocytic thyroiditis on fine needle aspiration cytology.
Abstract Background/Aims: Lymphocytic thyroiditis as cytology diagnosis from fine needle aspiration (FNA) is frequently detected in patients with thyroid nodules. However, the clinical outcome for upcoming hypothyroid events has been rarely clarified in euthyroid patients. Methods: We retrospectively reviewed the data of patient who had lymphocytic thyroitidis on FNA cytology of thyroid nodule from January 2005 to December 2010 at a tertiary referral hospital. In total, 109 patients with follow-up thyroid function tests (TFT) were enrolled. Final outcomes included overt and subclinical hypothyroidism with thy...
Source: The Korean Journal of Internal Medicine - March 13, 2018 Category: Internal Medicine Authors: Lee JM, Ha J, Jo K, Lim Y, Kim MH, Jung CK, Jung SL, Kang MI, Cha BY, Lim DJ Tags: Korean J Intern Med Source Type: research

Clinical significance of nuclear factor erythroid 2-related factor 2 in patients with chronic obstructive pulmonary disease.
Abstract Background/Aims: Several studies have identified a role for nuclear factor erythroid 2-related factor 2 (Nrf2) in the development of chronic obstructive pulmonary disease (COPD). However, the relationship between the plasma Nrf2 level and the extent of systemic inflammation associated with COPD status remains unclear. Methods: Patients diagnosed with COPD were recruited from St. Paul's Hospital, The Catholic University of Korea, between July 2009 and May 2012. Patients were classified into two groups according to the severity of their symptoms on initial presentation, a COPD-stable group (n = 25) and...
Source: The Korean Journal of Internal Medicine - March 13, 2018 Category: Internal Medicine Authors: Ban W, Kang HH, Kim IK, Ha JH, Joo H, Lee JM, Lim JU, Lee SH, Rhee CK Tags: Korean J Intern Med Source Type: research

Fundamental role of dendritic cells in inducing Th2 responses.
Abstract A mysterious puzzle in immunology is how the immune system decides what types of immune response to initiate against various stimuli. Although much is known about control of T helper 1 (Th1) and Th17 responses, the mechanisms that initiate Th2 responses remain obscure. Antigen-presenting cells, particularly dendritic cells (DCs), are mandatory for the induction of a Th cell response. Numerous studies have documented the organizing role of DCs in this process. The present review summarizes the fundamental roles of DCs in inducing Th2 responses. PMID: 29502361 [PubMed - as supplied by publisher] (Sourc...
Source: The Korean Journal of Internal Medicine - March 5, 2018 Category: Internal Medicine Authors: Kim B, Kim TH Tags: Korean J Intern Med Source Type: research

Clinical impact of healthcare-associated acquisition in cirrhotic patients with community-onset spontaneous bacterial peritonitis.
Conclusions: Hepatic functional status, renal dysfunction, and third-generation cephalosporin resistant pathogens more adversely affected the outcome of cirrhotic patients with community-onset SBP rather than HCA infection. The higher rate of third-generation cephalosporin resistance was notable in HCA SBP, which will require a novel approach to empirical antibiotic treatment selection in this population. PMID: 29502362 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 5, 2018 Category: Internal Medicine Authors: Kim J, Kang CI, Gwak GY, Chung DR, Peck KR, Song JH Tags: Korean J Intern Med Source Type: research

Performance of disposable endoscopic forceps according to the manufacturing techniques.
Conclusions: The molding forceps provided lower performance than the cutting and pressing forceps in terms of crush artifact. PMID: 29502363 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 5, 2018 Category: Internal Medicine Authors: Kwon CI, Kim G, Moon JP, Yun H, Ko WJ, Cho JY, Hong SP Tags: Korean J Intern Med Source Type: research

Time-dependent reversal of significant intrapulmonary shunt after liver transplantation.
Abstract Background/Aims: Although the association between intrapulmonary shunt (IPS) and liver cirrhosis is clear, data of repeated contrast echocardiography (CE) before and after liver transplantation (LT) to evaluate factors associated with IPS are limited. Methods: Hand-agitated saline was used for CE and, by assessing left-chamber opacification, IPS was classified as grade 0 to 4. Grade 3/4 constituted significant IPS and hepatopulmonary syndrome (HPS) was defined as significant IPS with the arterial partial pressure of oxygen
Source: The Korean Journal of Internal Medicine - March 5, 2018 Category: Internal Medicine Authors: Jin X, Sun BJ, Song JK, Roh JH, Jang JY, Kim DH, Lim YS, Song JM, Kang DH, Lee SG Tags: Korean J Intern Med Source Type: research

Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease.
Conclusions: Duodenal NPC1L1 expression was decreased in NAFLD and was negatively correlated with LXR expression in PMN cells. PMID: 29466845 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - February 23, 2018 Category: Internal Medicine Authors: Ahn SB, Jun DW, Jang K, Lee BH, Shin KJ Tags: Korean J Intern Med Source Type: research

Utility of shear wave elastography to detect papillary thyroid carcinoma in thyroid nodules: efficacy of the standard deviation elasticity.
Abstract Background/Aims: The aim of this study was to address the role of the elasticity index as a possible predictive marker for detecting papillary thyroid carcinoma (PTC) and quantitatively assess shear wave elastography (SWE) as a tool for differentiating PTC from benign thyroid nodules. Methods: One hundred and nineteen patients with thyroid nodules undergoing SWE before ultrasound-guided fine needle aspiration and core needle biopsy were analyzed. The mean (EMean), minimum (EMin), maximum (EMax), and standard deviation (ESD) of SWE elasticity indices were measured. Results: Among 105 nodules, 14 ...
Source: The Korean Journal of Internal Medicine - February 23, 2018 Category: Internal Medicine Authors: Kim HJ, Kwak MK, Choi IH, Jin SY, Park HK, Byun DW, Suh K, Yoo MH Tags: Korean J Intern Med Source Type: research

Costs and clinical outcomes of patients with diffuse large B-cell lymphoma in first remission: role of PET/CT surveillance.
Conclusions: Surveillance PET/CT resulted in similar clinical outcomes and medical costs compared to no surveillance PET/CT. Approximately half of patients with PET/CT findings of recurrence had no recurrence after follow-up imaging and biopsy, which would not have been carried out if PET/CT had not been performed in the first place. PMID: 29466847 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - February 23, 2018 Category: Internal Medicine Authors: Suh KJ, Kim KH, Kim R, Byun JM, Kim M, Park JH, Keam B, Kim TM, Kim JS, Choi IS, Heo DS Tags: Korean J Intern Med Source Type: research

Factors associated with treatment interruption in elderly patients with cancer.
Conclusions: The EORTC-QLQ-C30 physical functioning score and metastases to ≥ 2 organs, which indicate a poor physical functional status and metastatic high tumor burden, were significantly associated with interruption of first-line treatment in elderly patients with cancer. PMID: 29466848 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - February 23, 2018 Category: Internal Medicine Authors: Won HS, Sun S, Choi JY, An HJ, Ko YH Tags: Korean J Intern Med Source Type: research

Predictors of postoperative infectious complications in liver transplant recipients: experience of 185 consecutive cases.
This study was conducted to evaluate risk factors for infection and to review clinical characteristics. Methods: Medical records of patients who underwent LT from 2010 to 2014 were retrospectively analyzed. Binary logistic regression analysis was used to investigate risk factors of infection. Kaplan-Meier analysis was used to predict prognosis of infected and non-infected groups. Results: Of 185 recipients, 89 patients experienced infectious complications. The median follow-up period was 911 days (range, 9 to 2,031). The infected group had higher 1-year mortality (n = 22 [24.7%] vs. n = 8, [8.3%], p = 0.002), and...
Source: The Korean Journal of Internal Medicine - February 23, 2018 Category: Internal Medicine Authors: Lim S, Kim EJ, Lee TB, Choi BH, Park YM, Yang K, Ryu JH, Chu CW, Lee SJ Tags: Korean J Intern Med Source Type: research

Direct costs of severe cutaneous adverse reactions in a tertiary hospital in Korea.
Conclusions: The management of SCARs required considerable direct medical costs. SCARs are not only a health problem but also a significant financial burden for the affected individuals. PMID: 29466850 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - February 23, 2018 Category: Internal Medicine Authors: Yang MS, Kim JY, Kang MG, Lee SY, Jung JW, Cho SH, Min KU, Kang HR Tags: Korean J Intern Med Source Type: research

Seropositive rate of the anti-hepatitis A immunoglobulin G antibody in maintenance hemodialysis subjects from two hospitals in Korea.
Abstract Background/Aims: Hepatitis A virus (HAV) is a self-limiting infectious disease, but 1% of subjects develop fulminant hepatitis. The prevalence of the anti-HAV immunoglobulin G (IgG) antibody in hemodialysis subjects in Korea remains unknown. The purpose of this study was to describe and compare the seropositive rate of anti-HAV antibody among hemodialysis subjects in two hospitals according to age group. Methods: A total of 170 hemodialysis subjects were evaluated for the seropositive rate of the anti-HAV IgG antibody and its titer. Results: Of the 170 maintenance hemodialysis subjects in two ho...
Source: The Korean Journal of Internal Medicine - February 23, 2018 Category: Internal Medicine Authors: Kim H, Ryu J, Lee YK, Choi MJ, Cho A, Koo JR, Baik SY, Lee EH, Yoon JW, Noh JW Tags: Korean J Intern Med Source Type: research

Primary large cell neuroendocrine carcinoma of the common hepatic duct mimicking a Klatskin tumor.
PMID: 29466852 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - February 23, 2018 Category: Internal Medicine Authors: Koo JY, Kim KH, Kim TN Tags: Korean J Intern Med Source Type: research

Role of the renin-angiotensin system in hepatic fibrosis and portal hypertension.
Abstract The renin-angiotensin system (RAS) is an important regulator of cirrhosis and portal hypertension. As hepatic fibrosis progresses, levels of the RAS components angiotensin (Ang) II, Ang-(1-7), angiotensin-converting enzyme (ACE), and Ang II type 1 receptor (AT1R) are increased. The primary effector Ang II regulates vasoconstriction, sodium homoeostasis, fibrosis, cell proliferation, and inflammation in various diseases, including liver cirrhosis, through the ACE/Ang II/AT1R axis in the classical RAS. The ACE2/Ang-(1-7)/Mas receptor and ACE2/Ang-(1-9)/AT2R axes make up the alternative RAS and promote vasod...
Source: The Korean Journal of Internal Medicine - February 21, 2018 Category: Internal Medicine Authors: Shim KY, Eom YW, Kim MY, Kang SH, Baik SK Tags: Korean J Intern Med Source Type: research

Clinical and molecular characteristics of pulmonary sarcomatoid carcinoma.
Conclusions: PSC was more common in males, smokers, and the elderly, with worse prognosis than ordinary NSCLC; chemotherapy response was favorable, and EGFR mutation status and PD-L1 expression may offer more therapeutic options. PMID: 29458244 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - February 20, 2018 Category: Internal Medicine Authors: Sim JK, Chung SM, Choi JH, Oh JY, Lee SH, Kim JH, Min KH, Hur GY, Shim JJ, Kang KH, Shin BK, Lee JH, Lee SY Tags: Korean J Intern Med Source Type: research

Shen-Kang protects against tacrolimus-induced renal injury.
Conclusions: SK protects against TAC-induced renal injury. PMID: 29432674 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - February 12, 2018 Category: Internal Medicine Authors: Zhang LY, Jin J, Luo K, Piao SG, Zheng HL, Jin JZ, Lim SW, Choi BS, Yang CW, Li C Tags: Korean J Intern Med Source Type: research

Reevaluation of the impact of methicillin-resistance on outcomes in patients with Staphylococcus aureus bacteremia and endocarditis.
Abstract Background/Aims: Methicillin-resistant Staphylococcus aureus (MRSA) is highly prevalent in hospitals, and has recently emerged in the community. The impact of methicillin-resistance on mortality and medical costs for patients with S. aureus bacteremia (SAB) requires reevaluation. Methods: We searched studies with SAB or endocarditis using electronic databases including Ovid-Medline, Embase-Medline, and Cochrane Library, as well as five local databases for published studies during the period January 2000 to September 2011. Results: A total of 2,841 studies were identified, 62 of which involved 17...
Source: The Korean Journal of Internal Medicine - January 20, 2018 Category: Internal Medicine Authors: Joo EJ, Park DA, Kang CI, Chung DR, Song JH, Lee SM, Peck KR Tags: Korean J Intern Med Source Type: research

The usefulness of fecal calprotectin in assessing inflammatory bowel disease activity.
Abstract Background/Aims: Fecal calprotectin (FC) is known to correlate with disease activity and can be used as a predictor for relapse or treatment response in inflammatory bowel disease (IBD). We evaluated the usefulness of FC as a biomarker for disease activity in patients with IBD using both enzyme-linked immunosorbent assay (ELISA) and a quantitative point-of-care test (QPOCT). Methods: Fecal samples and medical records were collected from consecutive patients with IBD. FC levels were measured by both ELISA and QPOCT and patient medical records were reviewed for clinical, laboratory, and endoscopic data...
Source: The Korean Journal of Internal Medicine - January 20, 2018 Category: Internal Medicine Authors: Lee YW, Lee KM, Lee JM, Chung YY, Kim DB, Kim YJ, Chung WC, Paik CN Tags: Korean J Intern Med Source Type: research

Primary pyomyositis in North India: a clinical, microbiological, and outcome study.
Conclusions: Primary pyomyositis is not an uncommon disease entity. Patients with comorbidities were more likely to receive initial inappropriate antibiotic therapy. Patients with positive pus culture report had the higher rate of complications. Lower first-day serum albumin, initial inappropriate antibiotic therapy and advanced form of the disease at presentation were associated with increased in-hospital mortality. PMID: 29338140 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 18, 2018 Category: Internal Medicine Authors: Kumar S, Bhalla A, Singh R, Sharma N, Sharma A, Gautam V, Singh S, Varma S Tags: Korean J Intern Med Source Type: research

Efficacy and safety of tocilizumab in Korean patients with active rheumatoid arthritis.
Conclusions: TCZ infusion add-on is highly efficacious and well-tolerated in Korean patients with active RA refractory to conventional DMARDs including MTX. EULAR good response at week 12 could predict DAS28 remission at week 72. PMID: 29334721 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 17, 2018 Category: Internal Medicine Authors: Baek HJ, Lim MJ, Park W, Park SH, Shim SC, Yoo DH, Kim HA, Lee SK, Lee YJ, Park YE, Cha HS, Song YW Tags: Korean J Intern Med Source Type: research

Comparison of the morphologic criteria (RECIST) and metabolic criteria (EORTC and PERCIST) in tumor response assessments: a pooled analysis.
Abstract Background/Aims: The Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) or European Organization for Research and Treatment of Cancer (EORTC) criteria are used to assess metabolic tumor responses. However, tumor responses have shown considerable discrepancies between the morphologic criteria (Response Evaluation Criteria in Solid Tumors [RECIST]) and metabolic criteria. We performed this pooled study to compare the RECIST and metabolic criteria in the assessment of tumor responses. Methods: Electronic databases were searched for eligible articles with the terms "RECIST,&quo...
Source: The Korean Journal of Internal Medicine - January 17, 2018 Category: Internal Medicine Authors: Kim HD, Kim BJ, Kim HS, Kim JH Tags: Korean J Intern Med Source Type: research

Methacholine bronchial provocation test in patients with asthma: serial measurements and clinical significance.
Conclusions: The initial PC20, the duration of asthma, eosinophil concentrations, and quality-of-life may be useful variables to identify improvements in AHR in asthma patients. PMID: 29334723 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 17, 2018 Category: Internal Medicine Authors: Seo HJ, Lee PH, Kim BG, Lee SH, Park JS, Lee J, Park SW, Kim DJ, Park CS, Jang AS Tags: Korean J Intern Med Source Type: research

Disparity in Crohn's disease activity between home and clinics is associated with unscheduled hospital visits due to disease flares.
Conclusions: Disparity in disease activity is considerable in CD patients and is related to the risk of unscheduled hospital visit. PMID: 29334724 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 17, 2018 Category: Internal Medicine Authors: Kim ES, Lee YJ, Jang BI, Kim KO, Kim EY, Lee HS, Jeon SW, Kwak SG, Crohn’s and Colitis Association in Daegu-Gyeongbuk (CCAiD) Tags: Korean J Intern Med Source Type: research

New insights into the role of renal resident cells in the pathogenesis of lupus nephritis.
Abstract Systemic lupus erythematosus (SLE), an autoimmune disease of unknown etiology, is characterized by the production of autoantibodies and end-organ damage. Lupus nephritis affects up to 70% of patients with SLE and is the most critical predictor of morbidity and mortality. The immunopathogenesis of SLE is complex and most clinical trials of biologics targeting immune cells or their mediators have failed to show efficacy in SLE patients. It has therefore become increasingly clear that additional, local factors give rise to the inflammation and organ damage. In this review, we describe recent advances in the ...
Source: The Korean Journal of Internal Medicine - January 12, 2018 Category: Internal Medicine Authors: Kwok SK, Tsokos GC Tags: Korean J Intern Med Source Type: research

Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy?
Abstract Background/Aims: There has been no evidence for the necessity of endoscopy in asymptomatic young men with iron deficiency anemia (IDA). To determine whether endoscopy should be recommended in asymptomatic young men with IDA, we compared the prevalence of gastrointestinal (GI) lesions between young men (
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Kim NH, Park JH, Park DI, Sohn CI, Choi K, Jung YS Tags: Korean J Intern Med Source Type: research

Clinical features and prognoses of acute transverse myelitis in patients with systemic lupus erythematosus.
Conclusions: Higher disease activity in SLE and initial severe neurologic deficits might be associated with the poor outcome of ATM. Corticosteroid slowly tapering-off therapy might be helpful in preventing the recurrence of ATM. PMID: 29294596 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Ahn SM, Hong S, Lim DH, Ghang B, Kim YG, Lee CK, Yoo B Tags: Korean J Intern Med Source Type: research

MicroRNA-16 inhibits cell proliferation and migration by targeting heat shock protein 70 in heat-denatured dermal fibroblasts.
This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts. Methods: Primary human dermal fibroblasts were separated from normal human skin samples. Under heat stress, the levels of miR-16 and heat shock protein 70 (HSP70) were detected in primary human dermal fibroblasts by quantitative real-time polymerase chain reaction (qRT-PCR). Next, heat-denatured cells were transfected with synthetic scrambled negative control (NC) RNA (NC group), miR-16 mimics, miR-16 inhibitor or miR-16 inhibitor accompanied by small interfering RNA targeting HSP70, then th...
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Zhang C, Dai J, Fan Y, He X, Wei R Tags: Korean J Intern Med Source Type: research

Rapid onset of efficacy predicts response to therapy with certolizumab plus methotrexate in patients with active rheumatoid arthritis.
The objective of this study was to determine the efficacy and safety of add-on therapy with certolizumab pegol (CZP) in active rheumatoid arthritis (RA) patients of a single ethnicity. Methods: In this 24-week, phase 3, randomized, double-blind, placebo-controlled trial, eligible patients (n = 127) were randomized 2:1 to subcutaneous CZP + methotrexate (MTX; 400 mg at week 0, 2, and 4 followed by 200 mg every 2 weeks) or placebo + MTX. Results: At week 24, the American College of Rheumatology criteria for 20% (ACR20) response rate was significantly greater with CZP + MTX than with placebo (66.7% vs. 27.5%, p
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Kang YM, Park YE, Park W, Choe JY, Cho CS, Shim SC, Bae SC, Suh CH, Cha HS, Koh EM, Song YW, Yoo B, Lee SS, Park MC, Lee SH, Arendt C, Koetse W, Lee SK Tags: Korean J Intern Med Source Type: research

Transarterial embolization for incorrectable abdominal wall hematoma after abdominal paracentesis.
PMID: 29294599 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Moon SN Tags: Korean J Intern Med Source Type: research

Rapid changes in capillary morphology and architecture in a patient with dermatomyositis.
PMID: 29294600 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 4, 2018 Category: Internal Medicine Authors: Park SJ, Choi IH, Kim HS Tags: Korean J Intern Med Source Type: research