17 β-Estradiol reduces inflammation and modulates antioxidant enzymes in colonic epithelial cells.
17β-Estradiol reduces inflammation and modulates antioxidant enzymes in colonic epithelial cells. Korean J Intern Med. 2018 Oct 22;: Authors: Son HJ, Kim N, Song CH, Lee SM, Lee HN, Surh YJ Abstract Background/Aims: Estrogen is known to have protective effect in colorectal cancer development. The aims of this study are to investigate whether estradiol treatment reduces inflammation in CCD841CoN, a female human colonic epithelial cell line and to uncover underlying mechanisms of estradiol effects. Methods: 17β-Estradiol (E2) effect was measured by Western blot after inducing inf lammatio...
Source: The Korean Journal of Internal Medicine - October 20, 2018 Category: Internal Medicine Authors: Son HJ, Kim N, Song CH, Lee SM, Lee HN, Surh YJ Tags: Korean J Intern Med Source Type: research

Primary pancreatic small cell carcinoma diagnosed by endoscopic ultrasound-guided fine needle biopsy.
PMID: 30317845 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - October 16, 2018 Category: Internal Medicine Authors: Park SY, Choi KH, Chon HK Tags: Korean J Intern Med Source Type: research

The mortality benefit of carvedilol versus bisoprolol in patients with heart failure with reduced ejection fraction.
This study compares the effects of two BBs, carvedilol and bisoprolol, on survival in patients with HFrEF. Methods: The Korean Acute Heart Failure (KorAHF) registry is a prospective multicenter cohort that includes 5,625 patients who were hospitalized for acute heart failure (AHF). We selected 3,016 patients with HFrEF and divided this study population into two groups: BB at discharge (n = 1,707) or no BB at discharge (n = 1,309). Among patients with BB at discharge, subgroups were formed based on carvedilol prescription (n = 831), or bisoprolol prescription (n = 553). Propensity score matching analysis was performed....
Source: The Korean Journal of Internal Medicine - October 16, 2018 Category: Internal Medicine Authors: Choi KH, Lee GY, Choi JO, Jeon ES, Lee HY, Lee SE, Kim JJ, Chae SC, Baek SH, Kang SM, Choi DJ, Yoo BS, Kim KH, Cho MC, Park HY, Oh BH Tags: Korean J Intern Med Source Type: research

Comparison of three risk stratification models for non-clear cell renal cell carcinoma patients treated with temsirolimus as first-line therapy.
This study analyzed data for 74 patients with non-clear cell RCC who were treated with temsirolimus as the first-line therapy at eight medical centers between 2011 and 2016. The receiver-operating characteristic (ROC) curves for the different prognostic models were analyzed. Results: Twenty-seven (36.5%), 24 (32.4%), and 44 patients (59.5%) were assigned to the poor prognosis groups of the Memorial Sloan-Kettering Cancer Center (MSKCC), International Metastatic RCC Database Consortium (IMDC), and Advanced Renal Cell Carcinoma (ARCC) risk stratification models, respectively. All three prognostic models reliably discrim...
Source: The Korean Journal of Internal Medicine - October 12, 2018 Category: Internal Medicine Authors: Lee IH, Kang BW, Kim JG, Bae WK, Ki MS, Park I, Jo JC, Kim JY, Koh SA, Lee KH, Cho YY, Ryoo HM, Kwak SG, Lee JL, Lee SA Tags: Korean J Intern Med Source Type: research

Quality of information on the Internet for Korean patients with inflammatory bowel disease.
Abstract Background/Aims: The Internet is the main resource for health-related information. The incidence of inflammatory bowel disease (IBD) is rapidly increasing in Asian countries. However, the quality of websites for IBD available in this region has not been evaluated. We aimed to evaluate the quality of the information on IBD obtained from Korean websites. Methods: Using the terms "Crohn's disease" or "ulcerative colitis," websites were selected from those obtained with the three most renowned search engines in Korea; 60 websites from the results of each engine were chosen. The websit...
Source: The Korean Journal of Internal Medicine - September 28, 2018 Category: Internal Medicine Authors: Yoon JS, Lee SJ, Kim ES, Kim SK, Jung MK, Lee HS, Kwon YH, Nam SY, Jeon SW, Jin S, Lee JS, Yeo SJ Tags: Korean J Intern Med Source Type: research

Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013.
This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea. Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each class of antibiotic was converted to defined daily dose (DDD)/1,000 patient-days. We defined 3rd generation cephalosporins, 4th generation cephalosporins, β-lactam/β-lactamase inhibitors, and fluoroquinolones as broad-spectrum antibiotics; carbapenems, tigecycline, glycopeptides, oxazolidinone, and polymyxin were defined as antibio...
Source: The Korean Journal of Internal Medicine - September 27, 2018 Category: Internal Medicine Authors: Kim B, Hwang H, Kim J, Lee MJ, Pai H Tags: Korean J Intern Med Source Type: research

Prognostic role of beclin-1 in locally advanced non-small cell lung cancer in patients receiving docetaxel-platinum induction chemotherapy.
This study aimed to assess the clinicopathologic and prognostic significance of the excision repair cross-complementation group 1 (ERCC1), beclin-1, and glucose-regulated protein of molecular mass 78 (GRP78) in patients with locally advanced NSCLC receiving docetaxel-platinum IC, along with efficacy and safety. Methods: This is a retrospective observational cohort study. We reviewed medical records of 31 NSCLC patients receiving docetaxel-platinum IC, and conducted immunohistochemical staining of ERCC1, beclin-1, and GRP78. Results: Response rate was 67.8% with 10.7 months of median relapse-free survival (RFS) an...
Source: The Korean Journal of Internal Medicine - September 6, 2018 Category: Internal Medicine Authors: Lee HY, Shin JH, Lee KY, Park JK, Sung SW, Kim YS, Kang JH, Kim JO Tags: Korean J Intern Med Source Type: research

Clinical usefulness of remote patient monitoring using e-Health technologies in patients with inflammatory bowel diseases.
PMID: 30180515 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - September 1, 2018 Category: Internal Medicine Authors: Hong SN Tags: Korean J Intern Med Source Type: research

The euphoria, the warnings and the downfall of the current bioresorbale stents: could the journey be restarted?
PMID: 30180516 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - September 1, 2018 Category: Internal Medicine Authors: Kounis NG, Koniari I, Chourdakis E, Velissaris D, Hahalis G Tags: Korean J Intern Med Source Type: research

Jejunal diverticulosis.
PMID: 30099863 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 13, 2018 Category: Internal Medicine Authors: Ohira T, Iraha A, Kinjo T, Hokama A, Fujita J Tags: Korean J Intern Med Source Type: research

Effects of botulinum toxin injection on systemic sclerosis-related digital ulcers.
PMID: 30099864 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 13, 2018 Category: Internal Medicine Authors: Souk JW, Kim HS Tags: Korean J Intern Med Source Type: research

Cardiac computed tomography reveals aortic valve perforation in a patient with severe aortic regurgitation.
PMID: 30099865 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 13, 2018 Category: Internal Medicine Authors: Kim N, Kim SM, Park SJ, Choe YH Tags: Korean J Intern Med Source Type: research

Fever of unknown origin caused by intrathyroidal thymic carcinoma.
PMID: 30099866 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - August 13, 2018 Category: Internal Medicine Authors: Chung SM, Kim KJ, Moon JS, Hong YH, Kang SH Tags: Korean J Intern Med Source Type: research

Trend of multidrug and fluoroquinolone resistance in Mycobacterium tuberculosis isolates from 2010 to 2014 in Korea: a multicenter study.
This study was conducted to evaluate the recent prevalence and trend of anti-tuberculosis (TB) drug resistance with a focus on multidrug-resistance (MDR) and fluoroquinolone resistance in South Korea. Methods: We retrospectively reviewed the drug susceptibility testing results of culture-confirmed Mycobacterium tuberculosis isolates collected from 2010 to 2014 at seven tertiary hospitals in South Korea. Results: A total of 5,599 cases were included: 4,927 (88.0%) were new cases and 672 (12.0%) were previously treated cases. The MDR rate has significantly decreased from 6.0% in 2010 to 3.0% in 2014 among new cases...
Source: The Korean Journal of Internal Medicine - July 27, 2018 Category: Internal Medicine Authors: Kim H, Mok JH, Kang B, Lee T, Lee HK, Jang HJ, Cho YJ, Jeon D Tags: Korean J Intern Med Source Type: research

Immunoglobulin G4-related sclerosing cholangitis.
Abstract Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory condition of which IgG4-related sclerosing cholangitis (IgG4-SC) is the biliary manifestation. In this review, we provide an overview of IgG4-RD, with a focus on the biliary manifestations. In particular, we describe the important differential diagnoses of IgG4-SC, namely, primary sclerosing cholangitis and cholangiocarcinoma, outline diagnostic criteria for IgG4-SC, provide insight into possible pathophysiological mechanisms underlying the disease and discuss short and long-term management options of this recently described disea...
Source: The Korean Journal of Internal Medicine - July 27, 2018 Category: Internal Medicine Authors: Goodchild G, Pereira SP, Webster G Tags: Korean J Intern Med Source Type: research

Effects of aspirin resistance and mean platelet volume on vascular access failure in hemodialysis patients.
Conclusions: A high MPV was associated with an increased risk of VA failure, whereas aspirin resistance showed only a weak association. The MPV may predict VA survival in HD patients. PMID: 30025441 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - July 23, 2018 Category: Internal Medicine Authors: Cho A, Choi MJ, Lee YK, Hoon HC, Koo JR, Yoon JW, Noh JW Tags: Korean J Intern Med Source Type: research

Chilaiditi syndrome.
PMID: 30025442 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - July 23, 2018 Category: Internal Medicine Authors: Karaman O, Kahyaoglu M, Alpay E, Kalaycı A, Gecmen C Tags: Korean J Intern Med Source Type: research

Evaluation of high resolution computed tomography findings of cystic fibrosis.
Abstract Background/Aims: Morphological changes due to lung disease in patients with cystic fibrosis (CF) were evaluated using high resolution computed tomography (HRCT), and the HRCT scores obtained using the Bhalla scoring system were correlated with those obtained using clinical and laboratory indicators. Methods: Medical records of 28 children with CF who underwent chest CT in Department of Pediatric Allergy and Immunology, Cukurova University Balcali Hospital between March 2011 and January 2016 were retrospectively reviewed. Demographic data and physical examination, respiratory cultures, pulmonary funct...
Source: The Korean Journal of Internal Medicine - July 6, 2018 Category: Internal Medicine Authors: Sasihuseyinoglu AS, Altıntaş DU, Soyupak S, Dogruel D, Yılmaz M, Serbes M, Duyuler G Tags: Korean J Intern Med Source Type: research

Intravascular imaging analysis of a drug-eluting balloon followed by a bare metal stent compared to a drug-eluting stent for treatment of de novo lesions.
Conclusions: Treatment with DEB followed by BMS failed to improve strut malapposition despite higher in-stent neointimal growth, probably because of the inhomogeneous inhibition of in-stent neointimal hyperplasia by DEB. DEB technology should be improved to obtain even drug delivery to the vessel wall and homogeneous prevention of neointimal growth comparable to contemporary DES. PMID: 29961306 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - July 3, 2018 Category: Internal Medicine Authors: Choi W, Chae IH, Park JJ, Kim SH, Kang SH, Oh IY, Yoon CH, Cho YS, Youn TJ, Choi DJ Tags: Korean J Intern Med Source Type: research

Applications of kidney organoids derived from human pluripotent stem cells.
Abstract The establishment of protocols to differentiate kidney organoids from human pluripotent stem cells provides potential applications of kidney organoids in regenerative medicine. Modeling of renal diseases, drug screening, nephrotoxicity testing of compounds, and regenerative therapy are attractive applications. Although much progress still remains to be made in the development of kidney organoids, recent advances in clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated system 9 (Cas9) genome editing and three-dimensional bioprinting technologies have contributed to the applica...
Source: The Korean Journal of Internal Medicine - July 1, 2018 Category: Internal Medicine Authors: Kim YK, Nam SA, Yang CW Tags: Korean J Intern Med Source Type: research

Clinical usefulness of bioimpedance analysis for assessing volume status in patients receiving maintenance dialysis.
Abstract Chronic volume overload is associated with left ventricular hypertrophy and high cardiovascular mortality in patients undergoing dialysis. Therefore, estimating body fluid status is important in these patients. However, most dry-weight assessments are still performed clinically, while attempts have been made to measure the volume status and dry weight of patients undergoing dialysis using bioimpedance analysis (BIA). BIA uses the electrical properties of the human body to alternate current flow and measures resistance values to estimate body water content and composition. BIA is divided into single-freque...
Source: The Korean Journal of Internal Medicine - July 1, 2018 Category: Internal Medicine Authors: Park JH, Jo YI, Lee JH Tags: Korean J Intern Med Source Type: research

Hepatitis C virus infection in chronic kidney disease: paradigm shift in management.
Abstract Hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is associated with increased liver-related morbidity and mortality rates, accelerated progression to end-stage renal disease, and risk of cardiovascular events. CKD patients with HCV infection require antiviral therapy. Pegylated interferon (peg-IFN) plus ribavirin was the standard of care for HCV-infected CKD patients before the introduction of first-generation direct-acting antiviral (DAA) oral anti-HCV agents. Peg-IFN-based treatment has a low virologic response rate and poor compliance, resulting in a high dropout rate. Recently, severa...
Source: The Korean Journal of Internal Medicine - July 1, 2018 Category: Internal Medicine Authors: Kim SM, Song IH Tags: Korean J Intern Med Source Type: research

Transradial intervention as the first choice of treatment for ST elevation myocardial infarction patients: editorial comment.
PMID: 29961310 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - July 1, 2018 Category: Internal Medicine Authors: Lee BK Tags: Korean J Intern Med Source Type: research

Avoiding "curiosity killed the cat": personalized surveillance in post-resection colorectal cancer patients.
Avoiding "curiosity killed the cat": personalized surveillance in post-resection colorectal cancer patients. Korean J Intern Med. 2018 Jul;33(4):693-695 Authors: Park H, Lim J PMID: 29961311 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - July 1, 2018 Category: Internal Medicine Authors: Park H, Lim J Tags: Korean J Intern Med Source Type: research

Clinical factors affecting progression-free survival with crizotinib in ALK-positive non-small cell lung cancer.
Abstract Background/Aims: Although crizotinib is standard chemotherapy for advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC), clinical factors affecting progression-free survival (PFS) have not been reported. The purpose of this study was to identify clinical factors affecting PFS of crizotinib and develop a prognostic model for advanced ALK-positive NSCLC. Methods: Clinicopathologic features of patients enrolled in PROFILE 1001, 1005, 1007, and 1014 (training cohort) were reviewed. We conducted multivariate Cox analysis for PFS and overall survival (OS) in the training coh...
Source: The Korean Journal of Internal Medicine - June 29, 2018 Category: Internal Medicine Authors: Ock CY, Yoo SH, Keam B, Kim M, Kim TM, Jeon YK, Kim DW, Chung DH, Heo DS Tags: Korean J Intern Med Source Type: research

Atypical presentation of amniotic fluid embolism in liver and colon.
PMID: 29936778 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 25, 2018 Category: Internal Medicine Authors: Zizzo M, Mengoli MC, Zanelli M, Marco L, Lococo F, Ugoletti L, Pedrazzoli C Tags: Korean J Intern Med Source Type: research

Neuropathic cancer pain: prevalence, pathophysiology, and management.
Abstract Neuropathic cancer pain (NCP) is caused by nerve damage attributable to the cancer per se, and/or treatments including chemotherapy, radiotherapy, and surgery; the prevalence is reported to be as high as 40%. The etiologies of NCP include direct nerve invasion or nerve compression by the cancer, neural toxicity, chemotherapy, and radiotherapy. NCP is subdivided into plexopathy, radiculopathy, and peripheral neuropathies, among several other categories. The clinical characteristics of NCP differ from those of nociceptive pain in terms of both the hypersensitivity symptoms (burning, tingling, and an electri...
Source: The Korean Journal of Internal Medicine - June 23, 2018 Category: Internal Medicine Authors: Yoon SY, Oh J Tags: Korean J Intern Med Source Type: research

Use of serology and polymerase chain reaction to detect atypical respiratory pathogens during acute exacerbation of chronic obstructive pulmonary disease.
Conclusions: Serological testing suggested that infection by atypical pathogens during AECOPD was relatively uncommon. In addition, PCR provided no direct evidence of infection by atypical pathogens. Thus, atypical pathogens may not be a major cause of AECOPD in South Korea. PMID: 29929350 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 23, 2018 Category: Internal Medicine Authors: Jung CY, Choe YH, Lee SY, Kim WJ, Lee JD, Ra SW, Choi EG, Lee JS, Park MJ, Na JO Tags: Korean J Intern Med Source Type: research

Genetic markers of severe cutaneous adverse reactions.
Abstract Adverse drug reactions can cause considerable discomfort. They can be life-threatening in severe cases, requiring or prolonging hospitalization, impeding proper treatment, and increasing treatment costs considerably. Although the incidence of severe cutaneous adverse reactions (SCARs) is low, they can be serious, have permanent sequelae, or lead to death. A recent pharmacogenomic study confirmed that genetic factors can predispose an individual to SCARs. Genetic markers enable not only elucidation of the pathogenesis of SCARs, but also screening of susceptible subjects. The human leukocyte antigen (HLA) g...
Source: The Korean Journal of Internal Medicine - June 20, 2018 Category: Internal Medicine Authors: Jung JW, Kim JY, Park IW, Choi BW, Kang HR Tags: Korean J Intern Med Source Type: research

Current status of endoscopic submucosal dissection for early gastric cancer in Korea: role and benefits.
Conclusions: A majority of ESD for EGC were performed in tertiary care hospitals in Korea. The clinical status showed excellent clinical outcomes and did not differ by the year and between the types of hospitals in Korea. PMID: 29921044 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 20, 2018 Category: Internal Medicine Authors: Kim SG, Lyu DH, Park CM, Lee NR, Kim J, Cha Y, Jung HY Tags: Korean J Intern Med Source Type: research

Effect of vitamin D deficiency in Korean patients with acute respiratory distress syndrome.
Conclusions: Vitamin D deficiency was prevalent in Korean patients with ARDS. However, levels of vitamin D were not associated with mortality. A large, prospective study is needed to evaluate the effects of vitamin D deficiency on clinical outcomes of ARDS. PMID: 29914229 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 20, 2018 Category: Internal Medicine Authors: Park S, Lee MG, Hong SB, Lim CM, Koh Y, Huh JW Tags: Korean J Intern Med Source Type: research

Efficacy and safety of cisplatin and weekly docetaxel in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.
Conclusions: For patients with R/M HNSCC, a cisplatin and weekly docetaxel regimen showed high efficacy with tolerable toxicity as a first-line treatment. PMID: 29914230 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 20, 2018 Category: Internal Medicine Authors: Kim MJ, Kim SM, Jung HA, Hong JY, Chang WJ, Choi MK, Kim HS, Sun JM, Park K, Ahn MJ Tags: Korean J Intern Med Source Type: research

Vibrio vulnificus infection: a persistent threat to public health.
Abstract Vibrio vulnificus is a gram-negative bacterium that can cause serious, potentially fatal infections. V. vulnificus causes three distinct syndromes: an overwhelming primary septicemia caused by consuming contaminated seafood, wound infections acquired when an open wound is exposed to contaminated warm seawater, and gastrointestinal tract-limited infections. Case-fatality rates are higher than 50% for primary septicemia, and death typically occurs within 72 hours of hospitalization. Risk factors for V. vulnificus infection include chronic liver disease, alcoholism, and hematological disorders. When V. vulni...
Source: The Korean Journal of Internal Medicine - June 15, 2018 Category: Internal Medicine Authors: Yun NR, Kim DM Tags: Korean J Intern Med Source Type: research

Clarithromycin resistance and female gender affect Helicobacter pylori eradication failure in chronic gastritis.
Conclusions: Clarithromycin resistance and female gender are factors affecting H. pylori eradication failure in patients with chronic gastritis. PMID: 29898576 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 14, 2018 Category: Internal Medicine Authors: Chang YW, Ko WJ, Oh CH, Park YM, Oh SJ, Moon JR, Cho JH, Kim JW, Jang JY Tags: Korean J Intern Med Source Type: research

Nonpulmonary risk factors of acute respiratory distress syndrome in patients with septic bacteraemia.
Abstract Background/Aims: The relationship between nonpulmonary organ failure and the development of acute respiratory distress syndrome (ARDS) in patients with sepsis has not been well studied. Methods: We retrospectively reviewed the medical records of patients with septic bacteremia admitted to the medical intensive care unit (ICU) of a tertiary academic hospital between January 2013 and December 2016. Results: The study enrolled 125 patients of median age 73.0 years. Urinary (n = 47), hepatobiliary (n = 30), and pulmonary infections (n = 28) were the most common causes of sepsis; the incidence of ARD...
Source: The Korean Journal of Internal Medicine - June 14, 2018 Category: Internal Medicine Authors: Nam H, Jang SH, Hwang YI, Kim JH, Park JY, Park S Tags: Korean J Intern Med Source Type: research

Hepatic cystic echinococcosis due to Echinococcus granulosus, grossly observed by needle aspiration.
PMID: 29865777 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 6, 2018 Category: Internal Medicine Authors: Kang MK, Kim KH, Choi JH Tags: Korean J Intern Med Source Type: research

Diagnostic usefulness of the cytomegalovirus (CMV)-specific T cell-based assay for predicting CMV infection after kidney transplant.
Abstract Background/Aims: We evaluated the usefulness in kidney transplant (KT) candidates of cytomegalovirus (CMV)-specific enzyme-linked immunospot (ELISPOT) assays for predicting the development of post-transplant CMV infections. Methods: All adult recipients admitted for living-donor KT between March 2014 and March 2015 were prospectively enrolled except donor CMV-seropositive and recipient seronegative (D+/R-) recipients. All the enrolled patients underwent CMV-specific ELISPOT assays before transplant, and a researcher blinded to the results of these assays examined the patients for CMV infection at lea...
Source: The Korean Journal of Internal Medicine - June 6, 2018 Category: Internal Medicine Authors: Kim T, Lee HJ, Kim SM, Jung JH, Shin S, Kim YH, Sung H, Chong YP, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH, Han DJ Tags: Korean J Intern Med Source Type: research

The efficacy and safety of irsogladine maleate in nonsteroidal anti-inflammatory drug or aspirin-induced peptic ulcer and gastritis.
Conclusions: The efficacy of irsogladine maleate was found in H. pylori-negative group, suggesting its potential as a protective agent against NSAIDs or aspirin-induced peptic ulcer and gastritis. PMID: 29847892 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 1, 2018 Category: Internal Medicine Authors: Shim KN, Kim JI, Kim N, Kim SG, Jo YJ, Hong SJ, Shin JE, Kim GH, Park KS, Choi SC, Kwon JG, Kim JH, Kim HJ, Kim JW Tags: Korean J Intern Med Source Type: research

Clinical significance of Th17 cells in kidney transplantation.
Abstract Transplantation research has focused on cytotoxic T-cell and plasma cell/B-cell-targeted strategies, but little attention has been paid to the role of T helper 17 (Th17) cells in allograft dysfunction. However, accumulating evidence suggests that Th17 cells contribute to the development of acute and chronic allograft injury after transplantation of various organs, including the kidney. This review summarizes recent reports on the role of Th17 cells in kidney transplantation. Means of improving allograft outcomes by targeting the Th17 pathway are also suggested. PMID: 29843491 [PubMed - as supplied by...
Source: The Korean Journal of Internal Medicine - May 31, 2018 Category: Internal Medicine Authors: Chung BH, Yang CW, Cho ML Tags: Korean J Intern Med Source Type: research

Comparison of antiplatelet treatment in patients with clopidogrel nonresponders with or without carriage of CYP2C19 polymorphism.
Conclusions: Among clopidogrel nonresponders with cardiovascular disease on 75 mg daily clopidogrel, ticagrelor resulted in a comparable degree of platelet inhibition in all nonresponders compared with 150 mg daily clopidogrel or triple therapy with clopidogrel and cilostazol, irrespective of phenotype. PMID: 29843492 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2018 Category: Internal Medicine Authors: Ko YM, Kim JK, Kim JH, Park SH, Choi RK Tags: Korean J Intern Med Source Type: research

Surrogate decision making of chemotherapy consent: do we really provide informed consent of chemotherapy for patients?
Conclusions: This study suggests the lack of patients' own decision making for chemotherapy in some situations. This ethical dilemma must be considered for adequately informed decision making for chemotherapy while ensuring the patients' autonomy is maintained. PMID: 29843493 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2018 Category: Internal Medicine Authors: Kwon JH, Baek SK, Kim BS, Koh SJ, Ahn HK, Lim JH, Lim C, Kim DY Tags: Korean J Intern Med Source Type: research

Prolonged low-dose cyclophosphamide treatment after pulse therapy attenuates lung injury in rats with paraquat intoxication.
This study tested the hypothesis that prolonged low-dose cyclophosphamide (CTX) treatment after pulse therapy attenuate paraquat (PQ)-induced lung injury in rats. Methods: PQ (25 mg/kg) was administered intraperitoneally to induce PQ-intoxicated rat model. The rats were randomly divided into four groups: control group (1 mL/day saline solution for 14 days), PQ group (1 mL/day saline solution for 14 days after PQ exposure), pulse group (15 mg/kg/day CTX in 1 mL of saline solution for 2 days and subsequent 1 mL/day saline solution for 12 days), and prolonged low-dose group (15 mg/kg/day CTX in 1 mL of saline solution fo...
Source: The Korean Journal of Internal Medicine - May 31, 2018 Category: Internal Medicine Authors: Gao J, Feng S, Li Y Tags: Korean J Intern Med Source Type: research

Age at menarche and risk of colorectal adenoma.
Conclusions: Age at menarche, parity, use of female hormones, and menopause were not significantly associated with the risk of colorectal adenoma. Our findings indicate that reproductive factors including age at menarche do not affect the development of colorectal adenoma. PMID: 29843495 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2018 Category: Internal Medicine Authors: Kim NH, Park JH, Park DI, Sohn CI, Choi K, Jung YS Tags: Korean J Intern Med Source Type: research

Daclatasvir and asunaprevir combination therapy for patients with chronic hepatitis C virus genotype 1b infection in real world.
Conclusions: DCV and ASV combination therapy showed high rates of RVR, ETR, and SVR12 in chronic HCV genotype 1b-infected patients in real world and was well tolerated without serious adverse events. PMID: 29792020 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 25, 2018 Category: Internal Medicine Authors: Oh JY, Kim BS, Lee CH, Song JE, Lee HJ, Park JG, Hwang JS, Chung WJ, Jang BK, Kweon YO, Tak WY, Park SY, Jang SY, Suh JI, Kwak SG Tags: Korean J Intern Med Source Type: research

Palliative and end-of-life care for heart failure patients in an aging society.
Abstract The populations of Asian countries are expected to age rapidly in the near future, with a dramatic increase in the number of heart failure (HF) patients also anticipated. The need for palliative and end-of-life care for elderly patients with advanced HF is currently recognized in aging societies. However, palliative care and active treatment for HF are not mutually exclusive, and palliative care should be provided to reduce suffering occurring at any stage of symptomatic HF after the point of diagnosis. HF patients are at high risk of sudden cardiac death from the early stages of the disease onwards. The ...
Source: The Korean Journal of Internal Medicine - May 23, 2018 Category: Internal Medicine Authors: Okumura T, Sawamura A, Murohara T Tags: Korean J Intern Med Source Type: research

Painful erythematous nodules in the left finger pads.
PMID: 29779362 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 23, 2018 Category: Internal Medicine Authors: Yoo JR, Heo ST, Oh S, Joo SJ, Boo KY Tags: Korean J Intern Med Source Type: research

Long-term rivaroxaban for the treatment of acute venous thromboembolism in patients with active cancer in a prospective multicenter trial.
Conclusions: Rivaroxaban is effective and safe for the treatment of VTE in patients with active cancer. PMID: 29788694 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 23, 2018 Category: Internal Medicine Authors: Yhim HY, Choi WI, Kim SH, Nam SH, Kim KH, Mun YC, Oh D, Hwang HG, Lee KW, Song EK, Kwon YS, Bang SM Tags: Korean J Intern Med Source Type: research

Association between urinary sodium levels and iodine status in Korea.
Abstract Background/Aims: To evaluate the association between the urinary sodium concentration and iodine status in different age groups in Korea. Methods: This nationwide, population-based, cross-sectional study used data from the Korean National Health and Nutrition Examination Survey (VI 2-3, 2014 to 2015). We included 3,645 subjects aged 10 to 75 years with normal kidney function and without a history of thyroid disease. Adequate iodine intake was defined as a urinary iodine/creatinine (I/Cr) ratio of 85 to 220 µg/g. The urinary sodium/ creatinine (Na/Cr) ratios were classified as low ( 114 mmol/g)....
Source: The Korean Journal of Internal Medicine - May 18, 2018 Category: Internal Medicine Authors: Ahn J, Lee JH, Lee J, Baek JY, Song E, Oh HS, Kim M, Park S, Jeon MJ, Kim TY, Kim WB, Shong YK, Kim WG Tags: Korean J Intern Med Source Type: research

Kommerell's diverticulum: a rare cause of esophageal subepithelial lesion.
PMID: 29761792 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 16, 2018 Category: Internal Medicine Authors: Lee MW, Kim GH Tags: Korean J Intern Med Source Type: research

Albers-Sch önberg disease.
Albers-Schönberg disease. Korean J Intern Med. 2018 May 16;: Authors: Keng LT, Liang SK PMID: 29761793 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 16, 2018 Category: Internal Medicine Authors: Keng LT, Liang SK Tags: Korean J Intern Med Source Type: research