Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications.
Abstract Asthma is commonly recognized as a heterogeneous condition with a complex pathophysiology. With advances in the development of multiple medications for patients with asthma, most asthma symptoms are well managed. Nevertheless, 5% to 10% of adult asthmatic patients (called severe asthma) are in uncontrolled or partially controlled status despite intensive treatment. Especially, severe eosinophilic asthma is one of the severe asthma phenotypes characterized by eosinophilia in sputum/blood driven by type 2 immune responses. Eosinophils have been widely accepted as a central effector cell in the lungs. Some e...
Source: The Korean Journal of Internal Medicine - May 29, 2020 Category: Internal Medicine Authors: Choi Y, Sim S, Park HS Tags: Korean J Intern Med Source Type: research

Selecting coronavirus disease 2019 patients with negligible risk of progression: early experience from non-hospital isolation facility in Korea.
Conclusions: The risk of progression was negligible in COVID-19 patients who met the admission criteria for LTC at the time of diagnosis. LTCs could be a safe alternative considering shortage of hospital beds. PMID: 32460457 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 29, 2020 Category: Internal Medicine Authors: Choe PG, Kang EK, Lee SY, Oh B, Im D, Lee HY, Jung H, Kang CK, Kim MS, Park WB, Choi EH, Cho B, Oh MD, Kim NJ Tags: Korean J Intern Med Source Type: research

In vitro activity of lopinavir/ritonavir and hydroxychloroquine against severe acute respiratory syndrome coronavirus 2 at concentrations achievable by usual doses.
We examined the in vitro activity of lopinavir/ritonavir and hydroxychloroquine on SARS-CoV-2, at concentrations which can be used to treat coronavirus-19 patients with little concern of toxicity. Methods: Lopinavir/ritonavir (7/1.75 μg/mL), hydroxychloroquine base (1 or 2 μg/mL), or a combination thereof were administered 1 hour after the inoculation of SARS-CoV-2 to Vero cells at a multiplicity of infection of 0.05. We examined cytopathic effects of virus 48 hours after administration of the respective treatments and measured viral loads at three time points (0, 24, and 48 hours post-treatment) by quantitative...
Source: The Korean Journal of Internal Medicine - May 29, 2020 Category: Internal Medicine Authors: Kang CK, Seong MW, Choi SJ, Kim TS, Choe PG, Song SH, Kim NJ, Park WB, Oh MD Tags: Korean J Intern Med Source Type: research

Anxiety, depression, and stress in Korean patients with chronic urticaria.
Abstract Background/Aims: Emotional distress is thought to cause or maintain chronic urticaria (CU). We aimed to investigate the presence of anxiety, depression, and stress in Korean adult CU patients and to explore their potential impact on treatment. Methods: We enrolled 79 CU patients and a disease control group comprising 39 persistent asthma patients. The Hospital Anxiety and Depression Scale (HADS) was used to evaluate depression and anxiety. Stress and quality of life (QoL) were assessed by Stress Response Inventory and CU-QoL questionnaires. The sociodemographic and clinical data such as urticaria act...
Source: The Korean Journal of Internal Medicine - May 27, 2020 Category: Internal Medicine Authors: Choi GS, Nam YH, Park CS, Kim MY, Jo EJ, Park HK, Kim HK Tags: Korean J Intern Med Source Type: research

Efficacy and safety of mepolizumab in Korean patients with severe eosinophilic asthma from the DREAM and MENSA studies.
Conclusions: Mepolizumab treatment provided clinical benefits for Korean patients with severe eosinophilic asthma; the safety profile is consistent with the overall population. PMID: 32450626 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 26, 2020 Category: Internal Medicine Authors: Kim MK, Park HS, Park CS, Min SJ, Albers FC, Yancey SW, Mayer B, Kwon N Tags: Korean J Intern Med Source Type: research

Recent progress in the management of chronic cough.
Abstract Chronic cough is a common clinical condition with significant impact on quality of life and for which effective therapy remains an unmet clinical need. Over the past decade, there has been a major shift in how we approach this problem, driven by better appreciation of the clinical manifestation of chronic cough and an improved understanding of the associated neurobiology. "Cough hypersensitivity syndrome" has been proposed as a new diagnostic term for chronic cough, encompassing different phenotypes of the condition. Accumulating evidence suggests that this new concept is clinically relevant. Ho...
Source: The Korean Journal of Internal Medicine - May 20, 2020 Category: Internal Medicine Authors: Song WJ, An J, McGarvey L Tags: Korean J Intern Med Source Type: research

Association of body composition with disease activity and disability in rheumatoid arthritis.
Abstract Background/Aims: To explore the associations between body composition and pain, disease activity, and disability in rheumatoid arthritis (RA). Methods: The study enrolled 335 patients with RA and underwent body composition measurement with an InBody analyzer. The associations of body mass index (BMI), body fat mass, and skeletal muscle mass with disease activity score in 28 joints (DAS28), an index derived to measure the subjective component of DAS28 (DAS28-P), a pain visual analogue scale (VAS), and disability measured with the health assessment questionnaire (HAQ) were explored. Obesity was defined...
Source: The Korean Journal of Internal Medicine - May 15, 2020 Category: Internal Medicine Authors: Son KM, Kang SH, Seo YI, Kim HA Tags: Korean J Intern Med Source Type: research

Colonoscopy quality in community hospitals and nonhospital facilities in Korea.
Abstract Background/Aims: High-quality colonoscopy is essential to reduce colorectal cancer-related deaths. Little is known about colonoscopy quality in non-academic practice settings. We aimed to evaluate the quality of colonoscopies performed in community hospitals and nonhospital facilities. Methods: Colonoscopy data were collected from patients referred to six tertiary care centers after receiving colonoscopies at community hospitals and nonhospital facilities. Based on their photographs, we measured quality indicators including cecal intubation rate, withdrawal time, adequacy of bowel preparation, and nu...
Source: The Korean Journal of Internal Medicine - May 12, 2020 Category: Internal Medicine Authors: Lee JG, Han DS, Joo YE, Myung DS, Park DI, Kim SK, Jung Y, Lee WH, Kim ES, Yoon JS, Eun CS Tags: Korean J Intern Med Source Type: research

J-curve relationship between corrected QT interval and mortality in acute heart failure patients.
Conclusions: QTc interval was an independent predictor of overall death in male, but its significance decreased in female. The relationship between QTc interval and all-cause mortality was J-shaped in both sex. PMID: 32380800 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 8, 2020 Category: Internal Medicine Authors: Park CS, Cho HJ, Choi EK, Lee SE, Kim MS, Kim JJ, Choi JO, Jeon ES, Hwang KK, Chae SC, Baek SH, Kang SM, Yoo B, Choi DJ, Ahn Y, Kim KH, Cho MC, Oh BH, Lee HY Tags: Korean J Intern Med Source Type: research

Physical activity of Korean cancer survivors is associated with age and sex.
Conclusions: The prevalence of meeting exercise guidelines are low in Korean cancer survivors and varied by age and sex. Old age is associated with an insufficient level of aerobic exercise, and female sex is associated with low participation in resistance exercise. PMID: 32375206 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 7, 2020 Category: Internal Medicine Authors: Park JH, Lee JS, Ko YH, Kim YH Tags: Korean J Intern Med Source Type: research

Increased risk of gastric cancer in workers with occupational dust exposure.
Conclusions: Workers with occupational dust exposure were at higher risk of developing gastric cancer than the general population. Thus, future efforts for the prevention of gastric cancer are necessary for dust exposed workers. PMID: 32375207 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 7, 2020 Category: Internal Medicine Authors: Kang MY, Jung J, Koo JW, Kim I, Kim HR, Myong JP Tags: Korean J Intern Med Source Type: research

Risk for metabolic syndrome in the population with visceral fat area measured by bioelectrical impedance analysis.
Conclusions: Our study demonstrates that the combination of BMI assessment and VFA determination by BIA may be a useful method for predicting the risk of metabolic syndrome. The VFA by BIA may be a useful target for interventions to improve metabolic syndrome. PMID: 32340088 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 29, 2020 Category: Internal Medicine Authors: Jeon HH, Lee YK, Kim DH, Pak H, Shin SY, Seo JH Tags: Korean J Intern Med Source Type: research

Floating teeth in systemic sclerosis.
PMID: 32336054 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 29, 2020 Category: Internal Medicine Authors: Jun JB, Lee S, Bae J Tags: Korean J Intern Med Source Type: research

A genome wide association study for lung function in the Korean population using an exome array.
Conclusions: Our exome array analysis identified that several protein coding variants were associated with lung function in the Korean population. Common coding variants in SMIM29 (C6orf1), HMGA1, GIT2, FAM13A, TNXB, AGER and low-frequency variant in ARHGEF40 potentially affect lung function, which warrant further study. PMID: 32336055 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 29, 2020 Category: Internal Medicine Authors: Lee KS, Kim KH, Oh YM, Han B, Kim WJ Tags: Korean J Intern Med Source Type: research

Impact of subsequent chemotherapy on the survival of elderly patients with extensive stage small cell lung cancer.
Abstract Background/Aims: The prognosis of small cell lung cancer (SCLC) is still poor because of rapid recurrence, despite good response to initial chemotherapy. Additionally, patients' old ages and comorbidities are often obstacles that make it difficult to apply subsequent treatment after initial treatment. This retrospective study analyzed the correlation of post-progression survival (PPS) with overall survival (OS), and prognostic factors including comorbidities to figure out impact of subsequent chemotherapy on OS in elderly extensive disease SCLC. Methods: We analyzed 101 patients of age 65 years or ol...
Source: The Korean Journal of Internal Medicine - April 29, 2020 Category: Internal Medicine Authors: Kang EJ, Choi YJ, Lee SR, Sung HJ, Kim JS Tags: Korean J Intern Med Source Type: research

Shingles in palmar cutaneous branch of ulnar nerve.
PMID: 32306713 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 22, 2020 Category: Internal Medicine Authors: Min HK, Kim SH, Lee SH, Kim HR Tags: Korean J Intern Med Source Type: research

Extranodal marginal zone lymphoma: an unusual cause of gastric subepithelial tumor.
PMID: 32306714 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 22, 2020 Category: Internal Medicine Authors: Park EY, Kim GH Tags: Korean J Intern Med Source Type: research

Impact of early anti-TNF use on clinical outcomes in Crohn's disease: a nationwide population-based study.
Conclusions: Early anti-TNF therapy among Korean CD patients within 1 year of diagnosis was associated with better clinical outcomes than late therapy, such as lower surgery and ER visit rates. Our results suggest that aggressive medical intervention in the early stages of CD may potentially change the course of this disease. PMID: 32306709 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 21, 2020 Category: Internal Medicine Authors: Jung YS, Han M, Park S, Cheon JH Tags: Korean J Intern Med Source Type: research

Sarcopenia is associated with severe erectile dysfunction in older adults: a population-based cohort study.
Conclusions: Sarcopenia was associated with severe ED. Slow gait speed, and decreased muscle mass was independently associated with incident severe ED at 1 year. Further research is warranted to examine whether an intervention targeting these components can prevent severe ED. PMID: 32306710 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 21, 2020 Category: Internal Medicine Authors: Park H, Jang IY, Han M, Lee H, Jung HW, Lee E, Kim DH Tags: Korean J Intern Med Source Type: research

Risk factors of advanced metachronous neoplasms in surveillance after colon cancer resection.
Abstract Background/Aims: Regular surveillance colonoscopy after colon cancer resection is recommended for detecting metachronous adenoma and cancer. However, risk factors for metachronous neoplasms have not been fully evaluated. We aimed to assess risk factors for advanced metachronous neoplasms during surveillance colonoscopy after colon cancer resection. Methods: Patients who underwent curative colectomy for nonmetastatic colon cancer between January 2002 and December 2012 were evaluated and followed up to December 2017. Results: A total of 293 patients were enrolled in this study. Among these, 179 (6...
Source: The Korean Journal of Internal Medicine - April 21, 2020 Category: Internal Medicine Authors: Nam K, Shin JE Tags: Korean J Intern Med Source Type: research

Is immunological recovery clinically relevant at 100 days after allogeneic transplantation?
Conclusions: The immune recovery status post-allogeneic HSCT was affected by GVHD prophylactic regimens, especially in cases receiving tacrolimus-based GVHD prophylaxis, T-cell depletion, and possibly those manifesting acute GVHD. Delayed immune reconstitution might increase the morbidity due to viral reactivation. Treatment strategies are needed to prevent infectious complications and enhance immune reconstitution based on the immune recovery status following allogeneic HSCT with fludarabine-based conditioning. PMID: 32306712 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 21, 2020 Category: Internal Medicine Authors: Park J, Lim SH, Kim SH, Yun J, Kim CK, Lee SC, Won JH, Hong DS, Park SK Tags: Korean J Intern Med Source Type: research

Response to comment on "Incidence and risk factors for osteoporotic fractures in patients with systemic lupus erythematosus versus matched controls".
Response to comment on "Incidence and risk factors for osteoporotic fractures in patients with systemic lupus erythematosus versus matched controls". Korean J Intern Med. 2020 Apr 21;: Authors: Kim CS, Han KD, Choi HS, Bae EH, Ma SK, Kim SW PMID: 32306715 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 21, 2020 Category: Internal Medicine Authors: Kim CS, Han KD, Choi HS, Bae EH, Ma SK, Kim SW Tags: Korean J Intern Med Source Type: research

Comment on "Incidence and risk factors for osteoporotic fractures in patients with systemic lupus erythematosus versus matched controls".
Comment on "Incidence and risk factors for osteoporotic fractures in patients with systemic lupus erythematosus versus matched controls". Korean J Intern Med. 2020 Apr 21;: Authors: Lai SW PMID: 32306716 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 21, 2020 Category: Internal Medicine Authors: Lai SW Tags: Korean J Intern Med Source Type: research

Validation of the Korean Frailty Index in community-dwelling older adults in a nationwide Korean Frailty and Aging Cohort study.
Conclusions: The KFI and mKFI are valid instruments for frailty screening and might be useful as simple frailty screening tools to identify older adults who might benefit from comprehensive geriatric assessment and integrated, multidisciplinary geriatric care services. PMID: 32299182 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 17, 2020 Category: Internal Medicine Authors: Jung HW, Kim S, Won CW Tags: Korean J Intern Med Source Type: research

The therapeutic efficacy of water-soluble coenzyme Q10 in an experimental model of tacrolimus-induced diabetes mellitus.
Conclusions: CoQ10-W has better therapeutic efficacy than CoQ10-L in TAC-induced DM. PMID: 32279476 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 14, 2020 Category: Internal Medicine Authors: Quan Y, Luo K, Cui S, Lim SW, Shin YJ, Ko EJ, Kim JH, Chung SJ, Bae SK, Chung BH, Yang CW Tags: Korean J Intern Med Source Type: research

Treatment outcome and prognostic factors of Korean patients with chronic lymphocytic leukemia: a multicenter retrospective study.
Abstract Background/Aims: Compared with Western countries, chronic lymphocytic leukemia (CLL) rarely occurs in Asia and has different clinical characteristics. Thus, we aimed to evaluate the clinical characteristics, treatment outcomes, and prognostic significance of Korean patients with CLL. Methods: We retrospectively analyzed 90 patients with CLL who had received chemotherapy at 6 centers in Korea between 2000 and 2012. Results: Compared with Western patients with CLL, Korean patients with CLL express lambda (42.0%) and atypical markers such as CD22 and FMC7 (76.7% and 40.0%, respectively) more freque...
Source: The Korean Journal of Internal Medicine - April 14, 2020 Category: Internal Medicine Authors: Choi Y, Lee JH, Jung CW, Jo JC, Kim JS, Kim I, Park S, Cheong JW, Park SH, Kim SY, Lee HG Tags: Korean J Intern Med Source Type: research

Immature platelet fraction based diagnostic predictive scoring model for immune thrombocytopenia.
In this study, we assessed the usefulness of IPF and developed a diagnostic predictive scoring model for ITP. Methods: We retrospectively studied 568 patients with thrombocytopenia. Blood samples were collected and IPF quantified using a fully-automated hematology analyzer. We also estimated other variables that could affect thrombocytopenia by logistic regression analysis. Results: The median IPF was significantly higher in the ITP group than in the non-ITP group (8.7% vs. 5.1%). The optimal cut-off value of IPF for differentiating ITP was 7.0%. We evaluated other laboratory variables via logistic regression ana...
Source: The Korean Journal of Internal Medicine - April 10, 2020 Category: Internal Medicine Authors: Jeon MJ, Yu ES, Kang KW, Lee BH, Park Y, Lee SR, Sung HJ, Yoon SY, Choi CW, Kim BS, Kim DS Tags: Korean J Intern Med Source Type: research

Clinical outcomes of endovascular treatment for ruptured thoracic aortic disease.
Conclusions: Endovascular treatment achieves high technical success rates and acceptable clinical outcome. High transfusion volume and low MAP were associated with poor clinical outcomes. PMID: 32264656 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 10, 2020 Category: Internal Medicine Authors: Choi JH, Kim SP, Lee HC, Park TS, Park JH, Kim BW, Ahn J, Park JS, Lee HW, Oh JH, Choi JH, Cha KS, Hong TJ Tags: Korean J Intern Med Source Type: research

Association between high fatty liver index and development of colorectal cancer: a nationwide cohort study with 21,592,374 Korean.
This study investigated whether a high fatty liver index that reflects NAFLD correlates with CRC. Methods: Data from the National Health Insurance Corporation 2009 to 2012 were analyzed. NAFLD disease was defined as a fatty liver index> 60 in the absence of alcohol consumption of ≥ 30 g/day. Results: NAFLD was identified in 2,543,649 (11.8%) of 21,592,374 participants. CRC was identified in 19,785 (0.8%) of participants with NAFLD (fatty liver index ≥ 60) and in 80,871 (0.6%) participants without NAFLD (fatty liver index
Source: The Korean Journal of Internal Medicine - April 10, 2020 Category: Internal Medicine Authors: Choi YJ, Lee DH, Han KD Tags: Korean J Intern Med Source Type: research

Effect of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker on the patients with sepsis.
Conclusions: Pre-hospitalization use of ACE inhibitors or ARBs for sepsis was an independent factor for a lower rate of in-hospital mortality. PMID: 32264653 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 9, 2020 Category: Internal Medicine Authors: Lee HW, Suh JK, Jang E, Lee SM Tags: Korean J Intern Med Source Type: research

What are the illnesses associated with frailty in community-dwelling older adults: the Korean Frailty and Aging Cohort Study.
Abstract Background/Aims: Frailty is mainly due to an age-related decrease in the physiological reserves needed to maintain biological homeostasis, but it can also occur as a result of chronic diseases. The purpose of this study was to identify illnesses associated with frailty in Korean community-dwelling older adults. Methods: This was a cross-sectional study that included 2,936 older adults aged between 70 and 84 years who had completed both interviews and physical function assessments for the Korean Frailty and Aging Cohort Study. Current illnesses diagnosed by physicians were included in the analysis. Th...
Source: The Korean Journal of Internal Medicine - April 9, 2020 Category: Internal Medicine Authors: Kim S, Jung HW, Won CW Tags: Korean J Intern Med Source Type: research

Alcohol use disorder and liver transplant: new perspectives and critical issues.
Abstract Alcoholic liver disease is a consolidated indication for liver transplantation, but many unsolved issues can be highlighted. Patients with alcohol use disorder develop peculiar comorbidities that can become contraindications for transplantation. Moreover, a number of social and psychological patterns should be evaluated to select candidates with a low risk of alcohol relapse and adequate post-transplant adherence. In this context, the 6-month rule is too rigid to be widely applied. A short period of abstinence (1 to 3 months) is useful to estimate recovery of liver function and, possibly to avoid transpla...
Source: The Korean Journal of Internal Medicine - April 3, 2020 Category: Internal Medicine Authors: Gitto S, Aspite S, Golfieri L, Caputo F, Vizzutti F, Grandi S, Patussi V, Marra F Tags: Korean J Intern Med Source Type: research

Usefulness of BK virus-specific interferon- γ enzyme-linked immunospot assay for predicting the outcome of BK virus infection in kidney transplant recipients.
Usefulness of BK virus-specific interferon-γ enzyme-linked immunospot assay for predicting the outcome of BK virus infection in kidney transplant recipients. Korean J Intern Med. 2020 Apr 03;: Authors: Bae H, Na DH, Chang JY, Park KH, Min JW, Ko EJ, Lee H, Yang CW, Chung BH, Oh EJ Abstract Background/Aims: To investigate if BK virus (BKV)-specific T cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay can predict the outcome of BK virus infection in kidney transplant recipients (KTRs). Methods: We included 68 KTRs with different viremia status (no viremia...
Source: The Korean Journal of Internal Medicine - April 3, 2020 Category: Internal Medicine Authors: Bae H, Na DH, Chang JY, Park KH, Min JW, Ko EJ, Lee H, Yang CW, Chung BH, Oh EJ Tags: Korean J Intern Med Source Type: research

Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells.
Conclusions: This study suggested that combination therapy with metformin and nilotinib may have clinical benefits of enhancing antileukemia efficacy and overcoming resistance to nilotinib. PMID: 32241082 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 3, 2020 Category: Internal Medicine Authors: Na YJ, Yu ES, Kim DS, Lee DH, Oh SC, Choi CW Tags: Korean J Intern Med Source Type: research

Comparison of the efficacy and safety of direct-acting antiviral therapy with or without hepatitis C-related hepatocellular carcinoma.
Abstract Background/Aims: Chronic hepatitis C (CHC) treatment has dramatically improved since direct-acting antiviral (DAA) therapy was introduced. However, the use of DAA therapy in CHC patients with hepatocellular carcinoma (HCC) remains controversial. We investigated the DAA treatment response in CHC patients with HCC. Methods: We retrospectively analyzed CHC patients treated with DAA from 2016 to 2018. Patients were divided into two groups based on their HCC-history before DAA therapy. Baseline characteristics, sustained virologic response at 12 weeks (SVR 12), and HCC recurrence after DAA therapy were ev...
Source: The Korean Journal of Internal Medicine - April 3, 2020 Category: Internal Medicine Authors: Kwan BS, Kim JH, Park SJ, Choe WH, Kwon SY, Yoo BC Tags: Korean J Intern Med Source Type: research

Induction chemotherapy followed by concurrent chemoradiotherapy versus CCRT for locally advanced hypopharynx and base of tongue cancer.
Conclusions: This study failed to demonstrate that induction TPF chemotherapy improves survival in patients with BOT and hypopharynx cancer. However, it suggested a favorable outcome with IC to this population. PMID: 32241084 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 3, 2020 Category: Internal Medicine Authors: Lim SH, Sun JM, Hong J, Oh D, Ahn YC, Chung MK, Jeong HS, Son YI, Ahn MJ, Baek CH, Park K Tags: Korean J Intern Med Source Type: research

Atypical cutaneous features in a patient with adult-onset Still's disease.
PMID: 32229797 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 3, 2020 Category: Internal Medicine Authors: Jeong WS, Kim J, Heo ST, Kim JW, Yoo JR Tags: Korean J Intern Med Source Type: research

Wunderlich syndrome and regression of angiomyolipoma.
PMID: 32229794 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 31, 2020 Category: Internal Medicine Authors: Choi HS, Kim CS, Ma SK, Kim SW, Bae EH Tags: Korean J Intern Med Source Type: research

Comment on "Hydrochlorothiazide use and the risk of skin cancer in patients with hypertensive disorder: a nationwide retrospective cohort study from Korea".
Comment on "Hydrochlorothiazide use and the risk of skin cancer in patients with hypertensive disorder: a nationwide retrospective cohort study from Korea". Korean J Intern Med. 2020 Mar 31;: Authors: Pottegård A, Morales D PMID: 32229795 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 31, 2020 Category: Internal Medicine Authors: Pottegård A, Morales D Tags: Korean J Intern Med Source Type: research

Comparison of antimicrobial resistances and clinical features in community-onset Escherichia coli and Klebsiella pneumoniae bacteremia.
Abstract Background/Aims: The aim of this study was to compare antimicrobial resistance, clinical features, and outcomes of community-onset Escherichia coli (COEC) and Klebsiella pneumoniae (COKP) bacteremia. Methods: The medical records of patients diagnosed with E. coli or K. pneumoniae bacteremia in the emergency department of a 750-bed secondary care hospital in Daegu, Korea from January 2010 to December 2016 were retrospectively reviewed. Results: A total of 866 patients with COEC bacteremia and 299 with COKP bacteremia were enrolled. COEC bacteremia, compared to COKP bacteremia, had higher rates of...
Source: The Korean Journal of Internal Medicine - March 31, 2020 Category: Internal Medicine Authors: Sung HS, Lee JW, Bae S, Kwon KT Tags: Korean J Intern Med Source Type: research

Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma.
Conclusions: CCRT with cisplatin is effective for local control of ACC with manageable toxicity and may be an effective treatment option for locally advanced unresectable ACC. PMID: 32218101 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 30, 2020 Category: Internal Medicine Authors: Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS Tags: Korean J Intern Med Source Type: research

Characteristics of kidney transplantation recipients over time in South Korea.
Conclusions: In South Korea, the number of kidney transplantation in elderly or in patients with comorbidities has been increasing. Complex clinical factors were associated with medication compliance and patient prognosis. PMID: 32218102 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 30, 2020 Category: Internal Medicine Authors: Park S, Kim M, Kim JE, Kim K, Park M, Kim YC, Joo KW, Kim YS, Lee H Tags: Korean J Intern Med Source Type: research

Environmental risk factors and comorbidities of primary biliary cholangitis in Korea: a case-control study.
Conclusions: A family history of PBC, accompanying autoimmune diseases, and smoking were significantly associated with PBC. More induced abortions and less full-term deliveries were associated with PBC in women. In contrast, mild to moderate alcohol intake was negatively associated with PBC. Further studies are warranted to validate the results of this study and to search for clues about the pathogenesis of PBC. PMID: 32204000 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 26, 2020 Category: Internal Medicine Authors: Kim KA, Kim YS, Park SH, Chung WJ, Choi DH, Jang ES, Jeong SH Tags: Korean J Intern Med Source Type: research

Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma.
Conclusions: These results suggest that the dual blockade of TSLP and CRTH2 may serve as an effective treatment target for eosinophilic asthma. PMID: 32183504 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 19, 2020 Category: Internal Medicine Authors: Lee HY, Lee HY, Hur J, Kang HS, Choi JY, Rhee CK, Kang JY, Kim YK, Lee SY Tags: Korean J Intern Med Source Type: research

Fimasartan, an angiotensin II receptor antagonist, ameliorates an in vivo zebrafish model of heart failure.
In this study, we established a model of arrhythmia-induced heart failure (HF) in zebrafish and investigated the role of renin-angiotensin-aldosterone system (RAAS) modulation by using an angiotensin II type 1 receptor blocker, fimasartan, through the assessment of cellular and physiologic responses, morbidity, and mortality. Methods: HF was induced in zebrafish larvae by exposure to 20 μM terfenadine. Morphologic, physiologic, and functional parameters were assessed in the presence or absence of fimasartan treatment. Results: Zebrafish exposed to terfenadine showed marked dilatation of the ventricle and reduc...
Source: The Korean Journal of Internal Medicine - March 13, 2020 Category: Internal Medicine Authors: Quan H, Oh GC, Seok SH, Lee HY Tags: Korean J Intern Med Source Type: research

Continuous infusion versus intermittent bolus injection of propofol during endoscopic retrograde cholangiopancreatography.
Abstract Background/Aims: It is unclear whether continuous infusion or intermittent bolus injection of propofol is better for achieving adequate sedation in endoscopic retrograde cholangiopancreatography (ERCP). We aimed to compare the efficacy and safety of continuous infusion and intermittent bolus injection of propofol during therapeutic ERCP. Methods: In this prospective study, we randomly assigned 232 patients undergoing therapeutic ERCP to either continuous infusion (CI group, n = 113) or intermittent bolus injection (BI group, n = 119) of propofol. The primary outcome was the quality of sedation as ass...
Source: The Korean Journal of Internal Medicine - March 5, 2020 Category: Internal Medicine Authors: Lee JG, Yoo KS, Byun YJ Tags: Korean J Intern Med Source Type: research

Effect of corticosteroid therapy in the early phase of acute respiratory distress syndrome: a propensity-matched cohort study.
Conclusions: Corticosteroid therapy was not associated with 28- or 90-day mortality in the early phase of moderate to severe ARDS on propensity score matching analysis. PMID: 32114751 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 4, 2020 Category: Internal Medicine Authors: Baek MS, Lee Y, Hong SB, Lim CM, Koh Y, Huh JW Tags: Korean J Intern Med Source Type: research

Impaired fasting glucose levels in overweight or obese subjects for screening of type 2 diabetes in Korea.
We examined the concordance rate among fasting plasma glucose (FPG), 2-hour post-challenge glucose (2hr PG), and hemoglobin A1c (HbA1c) in the diagnosis of diabetes in a population with a high-risk for type 2 diabetes mellitus (T2DM) in Korea. Methods: Among the participants from the Korean Diabetes Prevention Study, individuals with FPG ≥ 100 mg/dL, body mass index (BMI) ≥ 23.0 kg/m2, and no previous history of T2DM were consecutively enrolled after a 75 g glucose tolerance test. We analyzed the differences in the clinical characteristics in subjects with stage 1 (FPG, 100 to 109 mg/dL) and stage 2 (FPG, 110 to...
Source: The Korean Journal of Internal Medicine - March 4, 2020 Category: Internal Medicine Authors: Lee JH, Chon S, Cha SA, Lim SY, Kim KR, Yun JS, Rhee SY, Yoon KH, Ahn YB, Woo JT, Ko SH, Korean Diabetes Prevention Study Investigators Tags: Korean J Intern Med Source Type: research

Derivation and validation of modified early warning score plus SpO2/FiO2 score for predicting acute deterioration of patients with hematological malignancies.
Conclusions: Compared to the traditional MEWS, the MEWS_SF score may be a useful tool that can be used in the general ward to identify deteriorating patients with hematological malignancies. PMID: 32114753 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 3, 2020 Category: Internal Medicine Authors: Lee JR, Jung YK, Kim HJ, Koh Y, Lim CM, Hong SB, Huh JW Tags: Korean J Intern Med Source Type: research

Feasibility of primary percutaneous coronary intervention via the distal radial approach in patients with ST-elevation myocardial infarction.
Conclusions: In the setting of STEMI, the DRA could be a feasible alternative access route for primary PCI. PMID: 32122114 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 3, 2020 Category: Internal Medicine Authors: Kim Y, Lee JW, Lee SY, Bae JW, Lee SJ, Jeong MH, Lee SH, Ahn Y Tags: Korean J Intern Med Source Type: research