Intravascular imaging analysis of a drug-eluting balloon followed by a bare metal stent compared to a drug-eluting stent for treatment of de novo lesions.
Conclusions: Treatment with DEB followed by BMS failed to improve strut malapposition despite higher in-stent neointimal growth, probably because of the inhomogeneous inhibition of in-stent neointimal hyperplasia by DEB. DEB technology should be improved to obtain even drug delivery to the vessel wall and homogeneous prevention of neointimal growth comparable to contemporary DES. PMID: 29961306 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - July 3, 2018 Category: Internal Medicine Authors: Choi W, Chae IH, Park JJ, Kim SH, Kang SH, Oh IY, Yoon CH, Cho YS, Youn TJ, Choi DJ Tags: Korean J Intern Med Source Type: research

Applications of kidney organoids derived from human pluripotent stem cells.
Abstract The establishment of protocols to differentiate kidney organoids from human pluripotent stem cells provides potential applications of kidney organoids in regenerative medicine. Modeling of renal diseases, drug screening, nephrotoxicity testing of compounds, and regenerative therapy are attractive applications. Although much progress still remains to be made in the development of kidney organoids, recent advances in clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated system 9 (Cas9) genome editing and three-dimensional bioprinting technologies have contributed to the applica...
Source: The Korean Journal of Internal Medicine - July 1, 2018 Category: Internal Medicine Authors: Kim YK, Nam SA, Yang CW Tags: Korean J Intern Med Source Type: research

Clinical usefulness of bioimpedance analysis for assessing volume status in patients receiving maintenance dialysis.
Abstract Chronic volume overload is associated with left ventricular hypertrophy and high cardiovascular mortality in patients undergoing dialysis. Therefore, estimating body fluid status is important in these patients. However, most dry-weight assessments are still performed clinically, while attempts have been made to measure the volume status and dry weight of patients undergoing dialysis using bioimpedance analysis (BIA). BIA uses the electrical properties of the human body to alternate current flow and measures resistance values to estimate body water content and composition. BIA is divided into single-freque...
Source: The Korean Journal of Internal Medicine - July 1, 2018 Category: Internal Medicine Authors: Park JH, Jo YI, Lee JH Tags: Korean J Intern Med Source Type: research

Hepatitis C virus infection in chronic kidney disease: paradigm shift in management.
Abstract Hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is associated with increased liver-related morbidity and mortality rates, accelerated progression to end-stage renal disease, and risk of cardiovascular events. CKD patients with HCV infection require antiviral therapy. Pegylated interferon (peg-IFN) plus ribavirin was the standard of care for HCV-infected CKD patients before the introduction of first-generation direct-acting antiviral (DAA) oral anti-HCV agents. Peg-IFN-based treatment has a low virologic response rate and poor compliance, resulting in a high dropout rate. Recently, severa...
Source: The Korean Journal of Internal Medicine - July 1, 2018 Category: Internal Medicine Authors: Kim SM, Song IH Tags: Korean J Intern Med Source Type: research

Transradial intervention as the first choice of treatment for ST elevation myocardial infarction patients: editorial comment.
PMID: 29961310 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - July 1, 2018 Category: Internal Medicine Authors: Lee BK Tags: Korean J Intern Med Source Type: research

Avoiding "curiosity killed the cat": personalized surveillance in post-resection colorectal cancer patients.
Avoiding "curiosity killed the cat": personalized surveillance in post-resection colorectal cancer patients. Korean J Intern Med. 2018 Jul;33(4):693-695 Authors: Park H, Lim J PMID: 29961311 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - July 1, 2018 Category: Internal Medicine Authors: Park H, Lim J Tags: Korean J Intern Med Source Type: research

Clinical factors affecting progression-free survival with crizotinib in ALK-positive non-small cell lung cancer.
Abstract Background/Aims: Although crizotinib is standard chemotherapy for advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC), clinical factors affecting progression-free survival (PFS) have not been reported. The purpose of this study was to identify clinical factors affecting PFS of crizotinib and develop a prognostic model for advanced ALK-positive NSCLC. Methods: Clinicopathologic features of patients enrolled in PROFILE 1001, 1005, 1007, and 1014 (training cohort) were reviewed. We conducted multivariate Cox analysis for PFS and overall survival (OS) in the training coh...
Source: The Korean Journal of Internal Medicine - June 29, 2018 Category: Internal Medicine Authors: Ock CY, Yoo SH, Keam B, Kim M, Kim TM, Jeon YK, Kim DW, Chung DH, Heo DS Tags: Korean J Intern Med Source Type: research

Atypical presentation of amniotic fluid embolism in liver and colon.
PMID: 29936778 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 25, 2018 Category: Internal Medicine Authors: Zizzo M, Mengoli MC, Zanelli M, Marco L, Lococo F, Ugoletti L, Pedrazzoli C Tags: Korean J Intern Med Source Type: research

Neuropathic cancer pain: prevalence, pathophysiology, and management.
Abstract Neuropathic cancer pain (NCP) is caused by nerve damage attributable to the cancer per se, and/or treatments including chemotherapy, radiotherapy, and surgery; the prevalence is reported to be as high as 40%. The etiologies of NCP include direct nerve invasion or nerve compression by the cancer, neural toxicity, chemotherapy, and radiotherapy. NCP is subdivided into plexopathy, radiculopathy, and peripheral neuropathies, among several other categories. The clinical characteristics of NCP differ from those of nociceptive pain in terms of both the hypersensitivity symptoms (burning, tingling, and an electri...
Source: The Korean Journal of Internal Medicine - June 23, 2018 Category: Internal Medicine Authors: Yoon SY, Oh J Tags: Korean J Intern Med Source Type: research

Use of serology and polymerase chain reaction to detect atypical respiratory pathogens during acute exacerbation of chronic obstructive pulmonary disease.
Conclusions: Serological testing suggested that infection by atypical pathogens during AECOPD was relatively uncommon. In addition, PCR provided no direct evidence of infection by atypical pathogens. Thus, atypical pathogens may not be a major cause of AECOPD in South Korea. PMID: 29929350 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 23, 2018 Category: Internal Medicine Authors: Jung CY, Choe YH, Lee SY, Kim WJ, Lee JD, Ra SW, Choi EG, Lee JS, Park MJ, Na JO Tags: Korean J Intern Med Source Type: research

Genetic markers of severe cutaneous adverse reactions.
Abstract Adverse drug reactions can cause considerable discomfort. They can be life-threatening in severe cases, requiring or prolonging hospitalization, impeding proper treatment, and increasing treatment costs considerably. Although the incidence of severe cutaneous adverse reactions (SCARs) is low, they can be serious, have permanent sequelae, or lead to death. A recent pharmacogenomic study confirmed that genetic factors can predispose an individual to SCARs. Genetic markers enable not only elucidation of the pathogenesis of SCARs, but also screening of susceptible subjects. The human leukocyte antigen (HLA) g...
Source: The Korean Journal of Internal Medicine - June 20, 2018 Category: Internal Medicine Authors: Jung JW, Kim JY, Park IW, Choi BW, Kang HR Tags: Korean J Intern Med Source Type: research

Current status of endoscopic submucosal dissection for early gastric cancer in Korea: role and benefits.
Conclusions: A majority of ESD for EGC were performed in tertiary care hospitals in Korea. The clinical status showed excellent clinical outcomes and did not differ by the year and between the types of hospitals in Korea. PMID: 29921044 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 20, 2018 Category: Internal Medicine Authors: Kim SG, Lyu DH, Park CM, Lee NR, Kim J, Cha Y, Jung HY Tags: Korean J Intern Med Source Type: research

Effect of vitamin D deficiency in Korean patients with acute respiratory distress syndrome.
Conclusions: Vitamin D deficiency was prevalent in Korean patients with ARDS. However, levels of vitamin D were not associated with mortality. A large, prospective study is needed to evaluate the effects of vitamin D deficiency on clinical outcomes of ARDS. PMID: 29914229 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 20, 2018 Category: Internal Medicine Authors: Park S, Lee MG, Hong SB, Lim CM, Koh Y, Huh JW Tags: Korean J Intern Med Source Type: research

Efficacy and safety of cisplatin and weekly docetaxel in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.
Conclusions: For patients with R/M HNSCC, a cisplatin and weekly docetaxel regimen showed high efficacy with tolerable toxicity as a first-line treatment. PMID: 29914230 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 20, 2018 Category: Internal Medicine Authors: Kim MJ, Kim SM, Jung HA, Hong JY, Chang WJ, Choi MK, Kim HS, Sun JM, Park K, Ahn MJ Tags: Korean J Intern Med Source Type: research

Vibrio vulnificus infection: a persistent threat to public health.
Abstract Vibrio vulnificus is a gram-negative bacterium that can cause serious, potentially fatal infections. V. vulnificus causes three distinct syndromes: an overwhelming primary septicemia caused by consuming contaminated seafood, wound infections acquired when an open wound is exposed to contaminated warm seawater, and gastrointestinal tract-limited infections. Case-fatality rates are higher than 50% for primary septicemia, and death typically occurs within 72 hours of hospitalization. Risk factors for V. vulnificus infection include chronic liver disease, alcoholism, and hematological disorders. When V. vulni...
Source: The Korean Journal of Internal Medicine - June 15, 2018 Category: Internal Medicine Authors: Yun NR, Kim DM Tags: Korean J Intern Med Source Type: research

Clarithromycin resistance and female gender affect Helicobacter pylori eradication failure in chronic gastritis.
Conclusions: Clarithromycin resistance and female gender are factors affecting H. pylori eradication failure in patients with chronic gastritis. PMID: 29898576 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 14, 2018 Category: Internal Medicine Authors: Chang YW, Ko WJ, Oh CH, Park YM, Oh SJ, Moon JR, Cho JH, Kim JW, Jang JY Tags: Korean J Intern Med Source Type: research

Nonpulmonary risk factors of acute respiratory distress syndrome in patients with septic bacteraemia.
Abstract Background/Aims: The relationship between nonpulmonary organ failure and the development of acute respiratory distress syndrome (ARDS) in patients with sepsis has not been well studied. Methods: We retrospectively reviewed the medical records of patients with septic bacteremia admitted to the medical intensive care unit (ICU) of a tertiary academic hospital between January 2013 and December 2016. Results: The study enrolled 125 patients of median age 73.0 years. Urinary (n = 47), hepatobiliary (n = 30), and pulmonary infections (n = 28) were the most common causes of sepsis; the incidence of ARD...
Source: The Korean Journal of Internal Medicine - June 14, 2018 Category: Internal Medicine Authors: Nam H, Jang SH, Hwang YI, Kim JH, Park JY, Park S Tags: Korean J Intern Med Source Type: research

Hepatic cystic echinococcosis due to Echinococcus granulosus, grossly observed by needle aspiration.
PMID: 29865777 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 6, 2018 Category: Internal Medicine Authors: Kang MK, Kim KH, Choi JH Tags: Korean J Intern Med Source Type: research

Diagnostic usefulness of the cytomegalovirus (CMV)-specific T cell-based assay for predicting CMV infection after kidney transplant.
Abstract Background/Aims: We evaluated the usefulness in kidney transplant (KT) candidates of cytomegalovirus (CMV)-specific enzyme-linked immunospot (ELISPOT) assays for predicting the development of post-transplant CMV infections. Methods: All adult recipients admitted for living-donor KT between March 2014 and March 2015 were prospectively enrolled except donor CMV-seropositive and recipient seronegative (D+/R-) recipients. All the enrolled patients underwent CMV-specific ELISPOT assays before transplant, and a researcher blinded to the results of these assays examined the patients for CMV infection at lea...
Source: The Korean Journal of Internal Medicine - June 6, 2018 Category: Internal Medicine Authors: Kim T, Lee HJ, Kim SM, Jung JH, Shin S, Kim YH, Sung H, Chong YP, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH, Han DJ Tags: Korean J Intern Med Source Type: research

The efficacy and safety of irsogladine maleate in nonsteroidal anti-inflammatory drug or aspirin-induced peptic ulcer and gastritis.
Conclusions: The efficacy of irsogladine maleate was found in H. pylori-negative group, suggesting its potential as a protective agent against NSAIDs or aspirin-induced peptic ulcer and gastritis. PMID: 29847892 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 1, 2018 Category: Internal Medicine Authors: Shim KN, Kim JI, Kim N, Kim SG, Jo YJ, Hong SJ, Shin JE, Kim GH, Park KS, Choi SC, Kwon JG, Kim JH, Kim HJ, Kim JW Tags: Korean J Intern Med Source Type: research

Clinical significance of Th17 cells in kidney transplantation.
Abstract Transplantation research has focused on cytotoxic T-cell and plasma cell/B-cell-targeted strategies, but little attention has been paid to the role of T helper 17 (Th17) cells in allograft dysfunction. However, accumulating evidence suggests that Th17 cells contribute to the development of acute and chronic allograft injury after transplantation of various organs, including the kidney. This review summarizes recent reports on the role of Th17 cells in kidney transplantation. Means of improving allograft outcomes by targeting the Th17 pathway are also suggested. PMID: 29843491 [PubMed - as supplied by...
Source: The Korean Journal of Internal Medicine - May 31, 2018 Category: Internal Medicine Authors: Chung BH, Yang CW, Cho ML Tags: Korean J Intern Med Source Type: research

Comparison of antiplatelet treatment in patients with clopidogrel nonresponders with or without carriage of CYP2C19 polymorphism.
Conclusions: Among clopidogrel nonresponders with cardiovascular disease on 75 mg daily clopidogrel, ticagrelor resulted in a comparable degree of platelet inhibition in all nonresponders compared with 150 mg daily clopidogrel or triple therapy with clopidogrel and cilostazol, irrespective of phenotype. PMID: 29843492 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2018 Category: Internal Medicine Authors: Ko YM, Kim JK, Kim JH, Park SH, Choi RK Tags: Korean J Intern Med Source Type: research

Surrogate decision making of chemotherapy consent: do we really provide informed consent of chemotherapy for patients?
Conclusions: This study suggests the lack of patients' own decision making for chemotherapy in some situations. This ethical dilemma must be considered for adequately informed decision making for chemotherapy while ensuring the patients' autonomy is maintained. PMID: 29843493 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2018 Category: Internal Medicine Authors: Kwon JH, Baek SK, Kim BS, Koh SJ, Ahn HK, Lim JH, Lim C, Kim DY Tags: Korean J Intern Med Source Type: research

Prolonged low-dose cyclophosphamide treatment after pulse therapy attenuates lung injury in rats with paraquat intoxication.
This study tested the hypothesis that prolonged low-dose cyclophosphamide (CTX) treatment after pulse therapy attenuate paraquat (PQ)-induced lung injury in rats. Methods: PQ (25 mg/kg) was administered intraperitoneally to induce PQ-intoxicated rat model. The rats were randomly divided into four groups: control group (1 mL/day saline solution for 14 days), PQ group (1 mL/day saline solution for 14 days after PQ exposure), pulse group (15 mg/kg/day CTX in 1 mL of saline solution for 2 days and subsequent 1 mL/day saline solution for 12 days), and prolonged low-dose group (15 mg/kg/day CTX in 1 mL of saline solution fo...
Source: The Korean Journal of Internal Medicine - May 31, 2018 Category: Internal Medicine Authors: Gao J, Feng S, Li Y Tags: Korean J Intern Med Source Type: research

Age at menarche and risk of colorectal adenoma.
Conclusions: Age at menarche, parity, use of female hormones, and menopause were not significantly associated with the risk of colorectal adenoma. Our findings indicate that reproductive factors including age at menarche do not affect the development of colorectal adenoma. PMID: 29843495 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2018 Category: Internal Medicine Authors: Kim NH, Park JH, Park DI, Sohn CI, Choi K, Jung YS Tags: Korean J Intern Med Source Type: research

Daclatasvir and asunaprevir combination therapy for patients with chronic hepatitis C virus genotype 1b infection in real world.
Conclusions: DCV and ASV combination therapy showed high rates of RVR, ETR, and SVR12 in chronic HCV genotype 1b-infected patients in real world and was well tolerated without serious adverse events. PMID: 29792020 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 25, 2018 Category: Internal Medicine Authors: Oh JY, Kim BS, Lee CH, Song JE, Lee HJ, Park JG, Hwang JS, Chung WJ, Jang BK, Kweon YO, Tak WY, Park SY, Jang SY, Suh JI, Kwak SG Tags: Korean J Intern Med Source Type: research

Palliative and end-of-life care for heart failure patients in an aging society.
Abstract The populations of Asian countries are expected to age rapidly in the near future, with a dramatic increase in the number of heart failure (HF) patients also anticipated. The need for palliative and end-of-life care for elderly patients with advanced HF is currently recognized in aging societies. However, palliative care and active treatment for HF are not mutually exclusive, and palliative care should be provided to reduce suffering occurring at any stage of symptomatic HF after the point of diagnosis. HF patients are at high risk of sudden cardiac death from the early stages of the disease onwards. The ...
Source: The Korean Journal of Internal Medicine - May 23, 2018 Category: Internal Medicine Authors: Okumura T, Sawamura A, Murohara T Tags: Korean J Intern Med Source Type: research

Painful erythematous nodules in the left finger pads.
PMID: 29779362 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 23, 2018 Category: Internal Medicine Authors: Yoo JR, Heo ST, Oh S, Joo SJ, Boo KY Tags: Korean J Intern Med Source Type: research

Long-term rivaroxaban for the treatment of acute venous thromboembolism in patients with active cancer in a prospective multicenter trial.
Conclusions: Rivaroxaban is effective and safe for the treatment of VTE in patients with active cancer. PMID: 29788694 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 23, 2018 Category: Internal Medicine Authors: Yhim HY, Choi WI, Kim SH, Nam SH, Kim KH, Mun YC, Oh D, Hwang HG, Lee KW, Song EK, Kwon YS, Bang SM Tags: Korean J Intern Med Source Type: research

Association between urinary sodium levels and iodine status in Korea.
Abstract Background/Aims: To evaluate the association between the urinary sodium concentration and iodine status in different age groups in Korea. Methods: This nationwide, population-based, cross-sectional study used data from the Korean National Health and Nutrition Examination Survey (VI 2-3, 2014 to 2015). We included 3,645 subjects aged 10 to 75 years with normal kidney function and without a history of thyroid disease. Adequate iodine intake was defined as a urinary iodine/creatinine (I/Cr) ratio of 85 to 220 µg/g. The urinary sodium/ creatinine (Na/Cr) ratios were classified as low ( 114 mmol/g)....
Source: The Korean Journal of Internal Medicine - May 18, 2018 Category: Internal Medicine Authors: Ahn J, Lee JH, Lee J, Baek JY, Song E, Oh HS, Kim M, Park S, Jeon MJ, Kim TY, Kim WB, Shong YK, Kim WG Tags: Korean J Intern Med Source Type: research

Kommerell's diverticulum: a rare cause of esophageal subepithelial lesion.
PMID: 29761792 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 16, 2018 Category: Internal Medicine Authors: Lee MW, Kim GH Tags: Korean J Intern Med Source Type: research

Albers-Sch önberg disease.
Albers-Schönberg disease. Korean J Intern Med. 2018 May 16;: Authors: Keng LT, Liang SK PMID: 29761793 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 16, 2018 Category: Internal Medicine Authors: Keng LT, Liang SK Tags: Korean J Intern Med Source Type: research

Successful treatment of tracheoesophageal fistula using a covered esophageal stent.
PMID: 29761794 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 16, 2018 Category: Internal Medicine Authors: Cheon YK, Kim JH Tags: Korean J Intern Med Source Type: research

Direct cholangioscopy with argon plasma coagulation of an intraductal papillary mucinous neoplasm of the bile duct.
PMID: 29761795 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 16, 2018 Category: Internal Medicine Authors: Cha B, Park JS, Jeong S, Lee DH, Kim JM Tags: Korean J Intern Med Source Type: research

Clinical analysis of 117 cases with synchronous multiple primary esophageal squamous cell carcinomas.
Abstract Background/Aims: We aimed to study the clinical characteristics, treatment modality, and the prognosis of synchronous multiple primary esophageal squamous cell carcinomas (SMPESCC). Methods: A total of 117 SMPESCC cases were evaluated retrospectively from 2010 to 2015. Results: The most common locations of SMPESCC were mid- and lower thoracic segments (n = 208, 84.9%). The 1-, 2-, and 3-year overall survival rates were 53.8%, 30.8%, and 15.4%, respectively; the median survival time (MST) was 12.5 months. With definitive radiotherapy and surgery, respectively, the MST of stage I/II patients were ...
Source: The Korean Journal of Internal Medicine - May 11, 2018 Category: Internal Medicine Authors: Chen Z, Li S, He Z, Li G Tags: Korean J Intern Med Source Type: research

Epidemiology of urticaria including physical urticaria and angioedema in Korea.
Conclusions: The prevalence of urticaria has increased annually in Korea. Cholinergic urticaria showed unique distribution in its age and gender, and angioedema showed remarkable increases in annual prevalence, although the prevalence estimation is still exploratory and diagnosis of urticaria based on ICD-10 codes need to be validated. PMID: 29742892 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 11, 2018 Category: Internal Medicine Authors: Seo JH, Kwon JW Tags: Korean J Intern Med Source Type: research

Standardized, musculoskeletal ultrasonographic reference values for healthy Korean adults.
Conclusions: We defined standard reference values for MSUS in healthy Korean adults. The reliabilities of interobserver agreements were high after appropriate training program. PMID: 29722248 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 4, 2018 Category: Internal Medicine Authors: Kim HS, Kim HR, Kim BY, Kim YS, Jung YO, Choi SJ, Kim HO, Hwang J, Lee S, Kim HA, Bang SY, Chai JY, Park SH, Yoon CH Tags: Korean J Intern Med Source Type: research

Epidemiologic features of ınflammatory bowel disease in Western Blacksea region of Turkey for the last 10 years: retrospective cohort study.
Conclusions: The incidence of inflammatory bowel disease seems to increase in Western Blacksea region at the last 10 years. This increment is more prevalent in rural areas. PMID: 29695147 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 27, 2018 Category: Internal Medicine Authors: Can G, Poşul E, Yılmaz B, Can H, Korkmaz U, Ermiş F, Kurt M, Dağlı Ü Tags: Korean J Intern Med Source Type: research

Recent advances in the diagnosis and management of primary myelofibrosis.
Abstract Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) in which dysregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathways is the major pathogenic mechanism. Most patients with PMF carry a driver mutation in the JAK2, MPL (myeloproliferative leukemia), or CALR (calreticulin) genes. Mutations in epigenetic regulators and RNA splicing genes may also occur, and play critical roles in PMF disease progression. Based on revised World Health Organization diagnostic criteria for MPNs, both screening for driver mutations and bone marrow biopsy are...
Source: The Korean Journal of Internal Medicine - April 20, 2018 Category: Internal Medicine Authors: Takenaka K, Shimoda K, Akashi K Tags: Korean J Intern Med Source Type: research

Effect of the anti-IL-17 antibody on allergic inflammation in an obesity-related asthma model.
Conclusions: These results suggest that the IL-17-leptin/adiponectin axis plays a key role in airway inflammation in obesity-related asthma. Our findings suggest a potential new treatment for IL-17 as a target that may benefit obesity-related asthma patients who respond poorly to typical asthma medications. PMID: 29665658 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 19, 2018 Category: Internal Medicine Authors: Liang L, Hur J, Kang JY, Rhee CK, Kim YK, Lee SY Tags: Korean J Intern Med Source Type: research

How to tackle congestion in acute heart failure.
Abstract Acute heart failure is a common complication of chronic heart failure and is associated with a high risk for subsequent mortality and morbidity. In 90% of case acute heart failure is the resultant of congestion, a manifestation of fluid build-up due to increased filling pressures. As residual congestion at discharge following an acute heart failure episodes is one of the strongest predictors of poor outcome, the goal of therapy should be to resolve congestion completely. Important to comprehend is that increased cardiovascular filling pressures are not solely the resultant of intravascular volume excess b...
Source: The Korean Journal of Internal Medicine - April 10, 2018 Category: Internal Medicine Authors: Martens P, Mullens W Tags: Korean J Intern Med Source Type: research

Experiences of magnetic resonance imaging scanning in patients with pacemakers or implantable cardioverter-defibrillators.
Conclusions: This single-center retrospective study found that MRI can be performed safely in patients with pacemakers or implantable cardioverter defibrillators, regardless of the MRI support, as long as appropriate precautions are taken. PMID: 29609452 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 4, 2018 Category: Internal Medicine Authors: Han D, Kang SH, Cho Y, Oh IY Tags: Korean J Intern Med Source Type: research

Korean physicians' policies for postoperative surveillance of colorectal cancer.
Conclusions: Korean physicians mostly followed up CRC using intensive postoperative surveillance. In preference to monitoring over a comparatively shorter period of time, the physicians tended to prefer monitoring patients post-operatively over a> 5 year period, particularly in cases of advanced-stage CRC. PMID: 29609453 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 4, 2018 Category: Internal Medicine Authors: Baek SK, Lee SC, Kim JG, Um JW, Lee SH, Jang BI, Park JJ, Kim TW Tags: Korean J Intern Med Source Type: research

Pre-discharge anemia as a predictor of adverse clinical outcomes in patients with acute decompensated heart failure.
Conclusions: Pre-discharge anemia, rather than anemia at admission, was identified as an independent predictor of mortality in patients with ADHF after surviving discharge. The results of the present study suggest that the identification and optimal management of anemia during hospitalization are important in patients with ADHF. PMID: 29562736 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 23, 2018 Category: Internal Medicine Authors: Kim MC, Kim KH, Cho JY, Lee KH, Sim DS, Yoon HJ, Yoon NS, Hong YJ, Park HW, Kim JH, Ahn Y, Jeong MH, Cho JG, Park JC Tags: Korean J Intern Med Source Type: research

Percutaneous coronary intervention in patients with multi-vessel coronary artery disease: a focus on physiology.
Abstract Multi-vessel coronary artery disease (MVD) frequently features ambiguous or intermediate lesions that may be both serial and complex, suggesting that multiple regions require revascularization. Percutaneous coronary intervention (PCI) is associated with various challenges such as appropriate identification of lesions that should be treated, the choice of an optimum revascularization method, and limitations of long-term outcomes. Optimal patient selection and careful targeting of lesions are key when planning treatment. Physiology-guided decision-making (based on the fractional flow reserve) can overcome t...
Source: The Korean Journal of Internal Medicine - March 21, 2018 Category: Internal Medicine Authors: Cho YK, Nam CW Tags: Korean J Intern Med Source Type: research

Treatment patterns of knee osteoarthritis patients in Korea.
Abstract Background/Aims: To evaluate the treatment patterns of knee osteoarthritis (OA) patients in South Korea. Methods: Using the Korean nationwide claims database, all knee OA patients in Korea during 2014 were identified by the knee OA diagnostic code (M17) or any OA diagnostic code (M15 to M19) in combination with a procedure for a knee X-ray. Patterns of medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids (CSs), analgesics, and symptomatic slow acting drugs for OA (SYSADOA) were analyzed. Prevalence and characteristics of knee OA patients who received a CS intra-articular...
Source: The Korean Journal of Internal Medicine - March 21, 2018 Category: Internal Medicine Authors: Park HR, Cho SK, Im SG, Jung SY, Kim D, Jang EJ, Sung YK Tags: Korean J Intern Med Source Type: research

Validation of the Friedewald formula for estimating low density lipoprotein cholesterol: the Korea National Health and Nutrition Examination Survey, 2009 to 2011.
Abstract Background/Aims: The aim of this study is to compare Friedewald-estimated and directly measured low density lipoprotein cholesterol (LDL-C) values and assess the concordance in guideline risk classification between the two methods. Methods: The data were derived from the 2009 to 2011 Korea National Health and Nutrition Examination Survey. We included subjects with triglyceride (TG) levels
Source: The Korean Journal of Internal Medicine - March 21, 2018 Category: Internal Medicine Authors: Lee J, Jang S, Jeong H, Ryu OH Tags: Korean J Intern Med Source Type: research

Expanding transcatheter aortic valve replacement into uncharted indications.
Abstract Since the first-in-man transcatheter delivery of an aortic valve prosthesis in 2002, the landscape of aortic stenosis therapeutics has shifted dramatically. While initially restricted to non-surgical cases, progressive advances in transcatheter aortic valve replacement and our understanding of its safety and efficacy have expanded its use in intermediate and possibly low surgical risk patients. In this review, we explore the past, present, and future of transcatheter aortic valve replacement. PMID: 29551053 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 20, 2018 Category: Internal Medicine Authors: Kang G, Kim JB Tags: Korean J Intern Med Source Type: research

Ezetimibe decreased nonalcoholic fatty liver disease activity score but not hepatic steatosis.
Conclusions: Ezetimibe decreased NAS without improving hepatic steatosis. PMID: 29551054 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 20, 2018 Category: Internal Medicine Authors: Lee HY, Jun DW, Kim HJ, Oh H, Saeed WK, Ahn H, Cheung RC, Nguyen MH Tags: Korean J Intern Med Source Type: research

A score for decision making during percutaneous coronary intervention in acute myocardial infarction patients with multivessel disease.
Conclusions: The results suggest that patients with a CONVERSE score of 3 or more should undergo MV PCI. PMID: 29551055 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 20, 2018 Category: Internal Medicine Authors: Jeong HC, Ahn JH, Kim MC, Sim DS, Park KH, Hong YJ, Kim JH, Jeong MH, Seung KB, Chang K, Ahn Y Tags: Korean J Intern Med Source Type: research