Association between primary immunodeficiency and asthma exacerbation in adult asthmatics.
Abstract Background/Aims: Primary immunodef iciency (PID) is a serious comorbid condition in adult asthmatics that have frequent exacerbations, which requires monthly replacement of intravenous immunoglobulin (IVIG). However, the prevalence and clinical significance of PID in adult asthmatics in Korea have not yet been reported. The aim of this study is to assess the prevalence of PID and its association with asthma exacerbation in Korean adult asthmatics. Methods: A total of 2,866 adult asthmatics were enrolled in this study. The PID group was defined as subjects who had lower levels of immunoglobulin G (IgG...
Source: The Korean Journal of Internal Medicine - June 13, 2019 Category: Internal Medicine Authors: Lee SH, Ban GY, Kim SC, Chung CG, Lee HY, Lee JH, Park HS Tags: Korean J Intern Med Source Type: research

Pilot study: asymptomatic hyperuricemia patients with obesity and nonalcoholic fatty liver disease have increased risk of double contour sign.
Conclusions: Asymptomatic hyperuricemia patients with class II obesity and NAFLD had increased risk of DCS. Determining the presence of crystal deposition, such as DCS, among patients with asymptomatic hyperuricemia might help determine whether early pharmacologic intervention is needed, especially with severe obesity or NAFLD. PMID: 31181878 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - June 13, 2019 Category: Internal Medicine Authors: Min HK, Cho H, Park SH Tags: Korean J Intern Med Source Type: research

Clinical efficacy of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in patients with multidrug-resistant bacteremia: a single-center study in Korea.
Conclusions: Our study showed that MALDI-TOF MS accelerated microorganism identification in patients with MDR bacteremia, but did not inf luence 28-day mortality. PMID: 31072077 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 11, 2019 Category: Internal Medicine Authors: Mok J, Jo EJ, Eom JS, Kim MH, Kim KU, Park HK, Lee MK, Lee K Tags: Korean J Intern Med Source Type: research

Full-dose sofosbuvir plus low-dose ribavirin for hepatitis C virus genotype 2-infected patients on hemodialysis.
Conclusions: In hemodialysis patients with HCV GT2 infection, the full-dose SOF plus low-dose RBV regimen appears to be safe and well tolerated, and yields high rates of sustained virologic response. PMID: 31064176 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 10, 2019 Category: Internal Medicine Authors: Seo HY, Seo MS, Yoon SY, Choi JW, Ko SY Tags: Korean J Intern Med Source Type: research

Supplementary nutrients for prevention of vascular calcification in patients with chronic kidney disease.
Abstract Vascular calcification (VC) and malnutrition associated with cardiovascular disease are common in patients with chronic kidney disease (CKD) treated with dialysis. VC, which reflects vascular aging, and malnutrition are also encountered in the non-CKD elderly population. This similarity of clinical findings suggests that the progression of CKD is related to aging and the existence of a causal relationship between VC and malnutrition. To retard renal progression, a low- or very-low-protein diet is usually recommended for CKD patients. Dietary education may induce malnutrition and deficiency of important nu...
Source: The Korean Journal of Internal Medicine - May 1, 2019 Category: Internal Medicine Authors: Lee SM, An WS Tags: Korean J Intern Med Source Type: research

Extracellular vesicles in renal physiology and clinical applications for renal disease.
Abstract Many cells in the nephron release extracellular vesicles (EVs). EVs envelop nucleic acids, proteins, and lipids. The surfaces of EVs express donor cell-specific markers, ligands, and major histocompatibility complex molecules. They are involved in cell-to-cell communication, immune modulation, and the removal of unwanted materials from cells. EVs have been studied as biomarkers of specific diseases and have potential therapeutic applications. Recent research has emphasized the functions of EVs in the kidney. This review provides an overview of recent findings related to the roles of EVs in the nephron, an...
Source: The Korean Journal of Internal Medicine - May 1, 2019 Category: Internal Medicine Authors: Kwon SH Tags: Korean J Intern Med Source Type: research

Adiponectin for the treatment of diabetic nephropathy.
Abstract The metabolic burden caused by hyperglycemia can result in direct and immediate metabolic injuries, such as oxidative stress and tissue inflammation, in the kidney. Furthermore, chronic hyperglycemia can lead to substantial structural changes such as formation of advanced glycation end-products, glomerular and tubular hypertrophy, and tissue fibrosis. Glomerular hypertrophy renders podocytes vulnerable to increased glomerular filtration, leading to podocyte instability and loss. Thus, prevention of glomerular hypertrophy and attenuation of glomerular hyperfiltration may have therapeutic potential for diab...
Source: The Korean Journal of Internal Medicine - May 1, 2019 Category: Internal Medicine Authors: Lee JY, Yang JW, Han BG, Choi SO, Kim JS Tags: Korean J Intern Med Source Type: research

Arterial stiffness and cardiovascular risk.
PMID: 31048659 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 1, 2019 Category: Internal Medicine Authors: Lee JG, Joo SJ Tags: Korean J Intern Med Source Type: research

Is sarcopenia a real risk factor for mortality in patients undergoing hemodialysis?
PMID: 31048660 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 1, 2019 Category: Internal Medicine Authors: Bae EH Tags: Korean J Intern Med Source Type: research

Effect of vitamin D deficiency in Korean patients with acute respiratory distress syndrome.
PMID: 31048661 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 1, 2019 Category: Internal Medicine Authors: Park S, Lee MG, Hong SB, Lim CM, Koh Y, Huh JW Tags: Korean J Intern Med Source Type: research

Comparison of clinical utility between diaphragm excursion and thickening change using ultrasonography to predict extubation success.
PMID: 31048662 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 1, 2019 Category: Internal Medicine Authors: Yoo JW, Lee SJ, Lee JD, Kim HC Tags: Korean J Intern Med Source Type: research

A prospective survey of the persistence of warfarin or NOAC in nonvalvular atrial fibrillation: a COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF).
This study included 3,381 patients who started OAC 30 days before enrollment (maintenance group) and 572 patients who newly started OAC (new-starter group). The persistence rate of OAC was evaluated. Results: In the maintenance group, persistence to OAC declined during 6 months, to 88.3% for VKA and 95.5% for NOAC (p
Source: The Korean Journal of Internal Medicine - April 25, 2019 Category: Internal Medicine Authors: Kim H, Lee YS, Kim TH, Cha MJ, Lee JM, Park J, Park JK, Kang KW, Shim J, Uhm JS, Park HW, Choi EK, Kim JB, Kim C, Kim J, Joung B Tags: Korean J Intern Med Source Type: research

Rheumatic complications in cancer patients treated with immune checkpoint inhibitors.
Abstract Immune checkpoint inhibitors (ICIs) have revolutionized anticancer therapy due to their long-term clinical benefits and immune boosting mechanisms. However, despite their consistent therapeutic effects, the use of ICIs is associated with a spectrum of adverse events due to their autoimmune and auto-inflammatory actions. These adverse events can affect any organ system, including the endocrine, neurologic, gastrointestinal, cardiac, skin, pulmonary, and musculoskeletal systems. Of the immune-related adverse events (irAEs), rheumatic complications are common and appear to be distinct from irAEs in other org...
Source: The Korean Journal of Internal Medicine - April 25, 2019 Category: Internal Medicine Authors: Lee KA, Kim HR, Yoon SY Tags: Korean J Intern Med Source Type: research

Comparative imaging of ectopic mediastinal parathyroid adenoma with magnetic resonance imaging and single photon emission computed tomography/ computed tomography: advantages of multimodality imaging.
PMID: 30995830 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 19, 2019 Category: Internal Medicine Authors: Liu X, Meng Z, Wang P, Jia Q Tags: Korean J Intern Med Source Type: research

HL301 in the treatment of acute bronchitis: a phase 2b, randomized, double-blind, placebocontrolled, multicenter study.
Abstract Background/Aims: There is insufficient quality data to recommend the use of herbs for the treatment of acute bronchitis. Small number of randomized trials of plant extracts for this purpose were determined to be low quality and there are concerns for the safety. HL301 is a combined product of seven medicinal plants. In the present study, we tried to evaluate the efficacy and safety of HL301 for the treatment of acute bronchitis with a randomized, double-blind, placebo-controlled, multicenter trial design. Methods: A total of 166 patients with acute bronchitis were randomized to receive placebo or HL3...
Source: The Korean Journal of Internal Medicine - April 9, 2019 Category: Internal Medicine Authors: Yoon SW, Park MJ, Rhee CK, Park JH, Lee SY, Kim DJ, Kim DG, Kim JY Tags: Korean J Intern Med Source Type: research

Right heart failure due to arteriovenous fistula after lumbar spine surgery.
Abstract PMID: 30962410 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 9, 2019 Category: Internal Medicine Authors: Park BW, Kwon SS, Lee MH, Goo DE, Nam BD Tags: Korean J Intern Med Source Type: research

Efficacy of long-term tenofovir disoproxil fumarate therapy in chronic hepatitis B patients with partial virologic response in real practice.
Abstract Background/Aims: The optimal management of chronic hepatitis B (CHB) patients with partial virologic response (PVR) to tenofovir disoproxil fumarate (TDF) remains unclear. We aimed to evaluate the long-term efficacy of prolonged TDF therapy in treatment-naïve CHB patients with PVR to TDF therapy in real practice. Methods: We retrospectively investigated the efficacy of prolonged TDF therapy in treatment-naïve CHB patients with PVR to TDF. PVR was defined as a decrease in serum hepatitis B virus (HBV) DNA over 2 log10 IU/mL from baseline, with detectable HBV DNA by real-time polymerase chain...
Source: The Korean Journal of Internal Medicine - April 8, 2019 Category: Internal Medicine Authors: Song JE, Lee CH, Kim BS Tags: Korean J Intern Med Source Type: research

Renal safety and urate-lowering efficacy of febuxostat in gout patients with stage 4-5 chronic kidney disease not yet on dialysis.
Abstract Background/Aims: The safety and efficacy of febuxostat in patients with stage 4-5 chronic kidney disease (CKD) are still unclear owing to a lack of studies in these patients. Therefore, we aimed to evaluate the effect of febuxostat on renal function, general safety, and efficacy in gout patients with stage 4-5 CKD. Methods: Among 739 patients who had been administered febuxostat from May 2012 to December 2016 at a single hospital in Korea, 370 patients who had been monitored for 1 year were analyzed. Serum uric acid levels and estimated glomerular filtration rate (eGFR) of patients with gouty arthrit...
Source: The Korean Journal of Internal Medicine - April 8, 2019 Category: Internal Medicine Authors: Kim SH, Lee SY, Kim JM, Son CN Tags: Korean J Intern Med Source Type: research

Real world data on follicular lymphoma patients treated by rituximab-containing immunochemotherapy and rituximab maintenance.
Conclusions: The survival outcomes of FL patients on rituximab maintenance after responding to R-CVP or R-CHOP were similar. Rituximab-containing immunochemotherapy followed by rituximab maintenance can be safely used for anti-HBc-positive patients if HBV DNA titer in blood can be regularly monitored. PMID: 30935195 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - April 4, 2019 Category: Internal Medicine Authors: Kim HK, Kang W, Sinn DH, Lee JH, Kim WS, Kim SJ Tags: Korean J Intern Med Source Type: research

The epidemiology of hepatitis B virus infection in Korea.
Abstract The global burden of hepatitis B virus (HBV) infection is profound, and represents a public health threat as chronic infection can lead to liver cirrhosis, hepatocellular carcinoma, and death. The risk factors for chronic hepatitis B-related liver disease differ according to HBV endemicity, hepatitis B e-antigen seropositivity, and viral load. It is important to identify these risk factors and start antiviral treatment at an appropriate time according to current guidelines. The most crucial step in reducing HBV infection is prevention in infancy or early childhood, as infection at an early stage may lead ...
Source: The Korean Journal of Internal Medicine - March 29, 2019 Category: Internal Medicine Authors: Yim SY, Kim JH Tags: Korean J Intern Med Source Type: research

The predictors of sustained virological response with sofosbuvir and ribavirin in patients with chronic hepatitis C genotype 2.
Conclusions: SOF/RBV treatment was effective and tolerable in HCV GT2 patients. RVR and no previous history of HCC were positive predictors of SVR12. PMID: 30879288 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 19, 2019 Category: Internal Medicine Authors: Han SY, Woo HY, Heo J, Park SG, Pyeon SI, Park YJ, Kim DU, Kim GH, Kim HH, Song GA, Cho M Tags: Korean J Intern Med Source Type: research

Gender differences in the presentation of chest pain in obstructive coronary artery disease: results from the Korean Women's Chest Pain Registry.
Conclusions: This is the first study to focus on gender differences in chest pain among Koreans with angina. Symptoms with high probability for OCAD were different between sexes. Our findings suggest that patient's medical history in pretest assessment for OCAD should be individualized considering gender. PMID: 30879289 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 19, 2019 Category: Internal Medicine Authors: Cho DH, Choi J, Kim MN, Kim HL, Kim YH, Na JO, Jeong JO, Yoon HJ, Shin MS, Kim MA, Hong KS, Shin GJ, Park SM, Shim WJ Tags: Korean J Intern Med Source Type: research

Cutaneous adverse drug reactions in patients with peripheral blood eosinophilia during antituberculosis treatment.
Conclusions: Peripheral blood eosinophilia is a relatively common occurrence during anti-TB treatment. Peripheral blood eosinophil counts were higher according to the degree of severity of CADRs. PMID: 30879290 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 19, 2019 Category: Internal Medicine Authors: Kim TO, Shin HJ, Kim YI, Lim SC, Koh YI, Kwon YS Tags: Korean J Intern Med Source Type: research

Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis.
Abstract About 21% of adults with osteoarthritis (OA) are diagnosed with concomitant depression in addition to chronic pain. Duloxetine, an anti-depressant medication, has been recently approved for managing Knee OA. We performed a systematic review to ascertain the efficacy and safety of duloxetine for OA. We searched MEDLINE, EMBASE, Web of Science, Google Scholar, and the Cochrane Database from inception to December 2018. Randomized clinical trials (RCTs) assessing the efficacy and/or safety of duloxetine versus placebo in OA patients were included. Data extraction and quality assessment were undertaken by two ...
Source: The Korean Journal of Internal Medicine - March 15, 2019 Category: Internal Medicine Authors: Osani MC, Bannuru RR Tags: Korean J Intern Med Source Type: research

Achalasia: treatment, current status and future advances.
LL Abstract Achalasia was first described in the 17th century and its treatment continues to be challenging. Palliative treatment involves disruption of the lower esophageal sphincter, which can be accomplished mechanically (balloon dilation or surgical myotomy) or chemically (Botox). True surgical treatment originated some 100 years ago and remained largely unchanged until the advent of thoracoscopic and then laparoscopic myotomy beginning in the 1980s. Because these procedures provided relatively definitive treatment and were well tolerated by patients, minimal invasive surgery assumed a primary role in the tre...
Source: The Korean Journal of Internal Medicine - March 15, 2019 Category: Internal Medicine Authors: Swanström LL Tags: Korean J Intern Med Source Type: research

Solitary fibrous tumor of the liver mimicking malignancy.
Abstract PMID: 30836742 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 8, 2019 Category: Internal Medicine Authors: Nam HC, Sung PS, Jung ES, Yoon SK Tags: Korean J Intern Med Source Type: research

Acute ST-elevation myocardial infarction due to prosthetic valve endocarditis after transcatheter aortic valve implantation.
Abstract PMID: 30836743 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 8, 2019 Category: Internal Medicine Authors: Cho JH, Han JK, Yang HM, Koo BK, Kim HS Tags: Korean J Intern Med Source Type: research

Massive ventilator-associated pleural empyema.
Abstract PMID: 30836744 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 8, 2019 Category: Internal Medicine Authors: Jud P, Fink-Neuboeck N, Lindenmann J Tags: Korean J Intern Med Source Type: research

Endoscopy training in Korea.
Abstract It is essential to maintain high-quality endoscopy given the increasing number of endoscopic screens performed in Korea. The training of fellows to perform endoscopies is challenging. The rapid development of endoscopic techniques and rising patient complexity increase the training pressures. At the end of training, all practitioners must perform endoscopy safely and effectively. Here, we examine the current status of endoscopy training in Korea. Although our system produces many competent endoscopists, there is room for improvement. Formal training programs should be developed to train the trainers. Spec...
Source: The Korean Journal of Internal Medicine - March 1, 2019 Category: Internal Medicine Authors: Kim JS, Kim BW Tags: Korean J Intern Med Source Type: research

Recent advances in the diagnosis and management of chronic pancreatitis.
Abstract Chronic pancreatitis is a chronic condition characterized by pancreatic inflammation that causes fibrosis and the destruction of exocrine and endocrine tissues. Chronic pancreatitis is a progressive disease, and no physiological treatment is available to reverse its course. However, with advances in medical technology, the existing diagnostic and treatment methods for chronic pancreatitis are evolving. Managing patients with chronic pancreatitis is challenging and necessitates a multidisciplinary approach. In this review, we discuss the recent advances in the diagnosis and management of chronic pancreatit...
Source: The Korean Journal of Internal Medicine - March 1, 2019 Category: Internal Medicine Authors: Kwon CI, Cho JH, Choi SH, Ko KH, Tirkes T, Gromski MA, Lehman GA Tags: Korean J Intern Med Source Type: research

Endoscopic management of anastomotic stricture after living-donor liver transplantation.
This article reviews the pathogenesis, diagnosis, endoscopic management, and long-term outcomes of post-liver transplantation biliary stricture, with a focus on anastomotic stricture. PMID: 30840808 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2019 Category: Internal Medicine Authors: Lee DW, Han J Tags: Korean J Intern Med Source Type: research

The utility of ezetimibe therapy in nonalcoholic fatty liver disease.
PMID: 30840809 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2019 Category: Internal Medicine Authors: Jun BG, Cheon GJ Tags: Korean J Intern Med Source Type: research

Fluoroquinolone resistance in multidrug-resistant tuberculosis patients.
PMID: 30840810 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2019 Category: Internal Medicine Authors: Lee HW, Yim JJ Tags: Korean J Intern Med Source Type: research

N-acetyl-l-cysteine controls osteoclastogenesis through regulating Th17 differentiation and RANKL production in rheumatoid arthritis.
PMID: 30840811 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - March 1, 2019 Category: Internal Medicine Authors: Kim HR, Kim KW, Kim BM, Lee KA, Lee SH Tags: Korean J Intern Med Source Type: research

Clinical profiles of patients with surgically resected pheochromocytoma and paraganglioma.
Conclusions: Out of 111 patients with surgically resected PPGLs, 88 (79.3%) were diagnosed as incidentalomas. Seven patients presented with transient cardiomyopathy and 16 with hypertension. Tumor location and secretion of catecholamine may vary depending on the presence of symptoms. PMID: 30808127 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - February 28, 2019 Category: Internal Medicine Authors: Lee SH, Park JH, Lee JY, Lee SR, Rhee KS, Chae JK, Kim WH, Sul JY, Oh JK, Kwon HJ, Lee JH, Seong IW Tags: Korean J Intern Med Source Type: research

Plasmablastic lymphoma presenting with ileocecal intussusception in an immunocompetent patient.
PMID: 30808128 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - February 28, 2019 Category: Internal Medicine Authors: Shin OR, Hyeon J, Kang SB, Kim JO Tags: Korean J Intern Med Source Type: research

Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis.
Conclusions: In patients with cirrhosis, those with concurrent elevation of HVPG and LS had the highest long-term mortality rates. However, when either HVPG or LS alone was elevated, mortality did not increase significantly. PMID: 30791681 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - February 24, 2019 Category: Internal Medicine Authors: Lee JG, Sohn JH, Jeong JY, Kim TY, Kim SM, Cho YS, Kim Y Tags: Korean J Intern Med Source Type: research

A paradigm shift in studies based on rheumatoid arthritis clinical registries.
This article will introduce representative registries for RA in each country set up in the early 2000s and will discuss future perspectives in clinical research on RA patients using such clinical registries. PMID: 30759964 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - February 16, 2019 Category: Internal Medicine Authors: Cho SK, Sung YK Tags: Korean J Intern Med Source Type: research

Liver volume index predicts the risk of esophageal variceal hemorrhage in cirrhotic patients on propranolol prophylaxis.
In this study, we sought to determine whether liver volume can predict the risk of primary prophylaxis failure in cirrhotic patients on NSBB therapy. Methods: A retrospective cohort of 309 patients on prophylactic propranolol was analyzed. Liver volume was measured in portal venous phase images of multidetector computed tomography. Predictors of VH were assessed using a Cox proportional hazards model with competing-risks analysis. A nomogram was developed for estimation of the risk of primary prophylaxis failure. Results: During a median follow-up of 36 months, 37 patients on propranolol developed VH. Liver volum...
Source: The Korean Journal of Internal Medicine - February 16, 2019 Category: Internal Medicine Authors: Kim BH, Chung JW, Lee CS, Jang ES, Jeong SH, Kim N, Kim JW Tags: Korean J Intern Med Source Type: research

Attitudes toward advance directives and prognosis in patients with heart failure: a pilot study.
Conclusions: The findings support the feasibility of the K-AD model, with a high acceptance rate in two-thirds of the sample. Further studies are warranted to investigate whether treatment preferences are associated with attitude towards ADs and/or HF prognosis using larger sample size. PMID: 30759965 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - February 15, 2019 Category: Internal Medicine Authors: Kim J, An M, Heo S, Shin MS Tags: Korean J Intern Med Source Type: research

Cellular immunotherapy in multiple myeloma.
Abstract In multiple myeloma (MM), the impaired function of several types of immune cells favors the tumor's escape from immune surveillance and, therefore, its growth and survival. Tremendous improvements have been made in the treatment of MM over the past decade but cellular immunotherapy using dendritic cells, natural killer cells, and genetically engineered T-cells represent a new therapeutic era. The application of these treatments is growing rapidly, based on their capacity to eradicate MM. In this review, we summarize recent progress in cellular immunotherapy for MM and its future prospects. PMID: 3075...
Source: The Korean Journal of Internal Medicine - February 15, 2019 Category: Internal Medicine Authors: Vo MC, Lakshmi TJ, Jung SH, Cho D, Park HS, Chu TH, Lee HJ, Kim HJ, Kim SK, Lee JJ Tags: Korean J Intern Med Source Type: research

A prospective randomized clinical study evaluating the efficacy and compliance of oral sulfate solution and 2-L ascorbic acid plus polyethylene glycol.
Abstract Background/Aims: Oral sulfate solution (OSS) is an emerging cleansing agent for bowel preparation. However, data comparing OSS to other conventional bowel preparations in Asian patients are limited. Therefore, the objective of this study was to compare the efficacy and tolerability of OSS to ascorbic acid plus polyethylene glycol (AA + PEG) in Asian patients. Methods: This was a prospective, randomized, parallel, investigator-blind study performed in two university hospitals in Korea. Bowel preparation efficacy was evaluated using both the Ottawa Bowel Preparation Scale (OBPS) and Boston Bowel Prepar...
Source: The Korean Journal of Internal Medicine - January 30, 2019 Category: Internal Medicine Authors: Kwon KH, Lee JA, Lim YJ, Lee BJ, Joo MK, Sim YR, Choi W, Kim T, Kim JY, Cho ER, Jeen YT, Park JJ Tags: Korean J Intern Med Source Type: research

Prognostic significance of malnutrition for long-term mortality in community-acquired pneumonia: a propensity score matched analysis.
This study evaluated the prevalence and prognostic significance of malnutrition in a Korean population with CAP. Methods: In total, 198 patients with CAP from November 2014 to September 2015 were analyzed retrospectively. We assessed the prevalence of malnutrition and the risk factors for 2-year mortality. Furthermore, we divided the patients into two groups: elderly (age ≥ 65 years, n = 131) and non-elderly (age
Source: The Korean Journal of Internal Medicine - January 29, 2019 Category: Internal Medicine Authors: Yeo HJ, Byun KS, Han J, Kim JH, Lee SE, Yoon SH, Jeon D, Kim YS, Cho WH Tags: Korean J Intern Med Source Type: research

Outcomes and clinical relevance of stool multiplex bacterial polymerase chain reaction in patients with acute diarrhea: single center experience.
This study investigates the clinical usefulness of a stool multiplex bacterial PCR in patients with acute diarrhea. Methods: We retrospectively evaluated the stool multiplex bacterial PCR results, clinical parameters, and clinical courses of patients hospitalized because of acute diarrhea between August 2014 and November 2016. Results: A total of 725 patients (male, 372; mean age, 30.9 ± 29.3 years) underwent stool multiplex bacterial PCR. A total of 243 pathogens were detected in 226 patients. The detection rate of multiplex PCR testing was higher than that of stool culture (32.7% vs. 3.3%, p
Source: The Korean Journal of Internal Medicine - January 29, 2019 Category: Internal Medicine Authors: Kwack WG, Lim YJ, Kwon KH, Chung JW, Oh JY Tags: Korean J Intern Med Source Type: research

Clinical features and recurrent attack in gout patients according to serum urate levels during an acute attack.
Abstract Background/Aims: A substantial portion of gout patients have normal serum urate levels during an acute attack but data on the clinical characteristics and risk of recurrence compared with hyperuricemic patients are limited. Methods: In this retrospective cohort study, clinical features of normouricemic and hyperuricemic patients were compared. Multivariate analysis was performed to determine whether normouricemic patients were less likely to have a recurrent attack. Results: Among a total of 221 gout patients, 88 (39.8%) had normouricemia during an acute attack. Postsurgical gout (22.7% vs. 6.0%, p
Source: The Korean Journal of Internal Medicine - January 28, 2019 Category: Internal Medicine Authors: Lee JS, Kwon OC, Oh JS, Kim YG, Lee CK, Yoo B, Hong S Tags: Korean J Intern Med Source Type: research

D-dimer/troponin ratio in the differential diagnosis of acute pulmonary embolism from non-ST elevation myocardial infarction.
Abstract Background/Aims: The aim of this study was to investigate useful cardiac biomarkers in the differential diagnosis of acute pulmonary embolism (APE) with troponin elevation from acute non-ST elevation myocardial infarction (NSTEMI). Methods: A total of 771 consecutive NSTEMI patients with D-dimer measurements and 90 patients with troponin-I (TnI) elevation out of 233 APE patients were enrolled, and cardiac biomarkers were compared. Results: D-dimer elevation was noted in 382 patients with NSTEMI (49.5%), and TnI elevation was noted 90 out of 233 APE patients (38.6%). Unnecessary coronary angiogra...
Source: The Korean Journal of Internal Medicine - January 28, 2019 Category: Internal Medicine Authors: Kim JY, Kim KH, Cho JY, Sim DS, Yoon HJ, Yoon NS, Hong YJ, Park HW, Kim JH, Ahn Y, Jeong MH, Cho JG, Park JC Tags: Korean J Intern Med Source Type: research

Immunological measurement of aspartate/alanine aminotransferase in predicting liver fibrosis and inflammation.
The objective of this study was to evaluate the efficacy of immunoassay in predicting liver fibrosis and inflammation. Methods: A total of 219 patients with chronic hepatitis B (CHB) who underwent hepatic venous pressure gradient (HVPG) and liver biopsy before antiviral therapy were recruited. Serum samples were prepared from blood during HVPG. Results of biochemical parameters including enzymatic AST/ALT and immunological assays of cAST, mAST, ALT1, and ALT2 through sandwich enzyme-linked immunosorbent assay (ELISA) immunoassay with fluorescence labeled monoclonal antibodies were compared with the results of METAVIR ...
Source: The Korean Journal of Internal Medicine - January 23, 2019 Category: Internal Medicine Authors: Kim HJ, Kim SY, Shin SP, Yang YJ, Bang CS, Baik GH, Kim DJ, Ham YL, Choi EY, Suk KT Tags: Korean J Intern Med Source Type: research

A rare case of an enlarged celiac lymph node diagnosed as an epidermal inclusion cyst.
PMID: 30654604 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 18, 2019 Category: Internal Medicine Authors: Kim SB, Kim KH, Kim TN, Cho CW, Choi JH Tags: Korean J Intern Med Source Type: research

Clinical impact of anti-thymocyte globulin on survival and graft-versus-host disease in patients undergoing human leukocyte antigen mismatched allogeneic stem cell transplantation.
Conclusions: The low to medium doses of ATG may be associated with improving survival outcomes and reducing incidence of ecGVHD without enhancing the chances of relapse in patients with acute leukemia or myelodysplastic syndrome undergoing non-TBI-based HLA-mismatched allogeneic HSCT. PMID: 30616303 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - January 10, 2019 Category: Internal Medicine Authors: Kim T, Choi Y, Lee JH, Park S, Ahn JS, Moon JH, Shin HJ, Lee WS, Kim D, Lee HS Tags: Korean J Intern Med Source Type: research

Molecular targeted therapies for microscopic polyangiitis and granulomatosis with polyangiitis.
Abstract Clinical trials and observational studies have established cyclophosphamide (CY) or rituximab plus glucocorticoid (GC) as standard remission induction therapies in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). However, because these regimens are associated with serious adverse drug reactions, the development of drugs with novel mechanisms of actions are needed. Progress in basic and clinical research has identified novel candidate targeting molecules, including B-cell activating factor (BAF), C5a receptor, and interleukin-6. The combination of rituximab and BAF b...
Source: The Korean Journal of Internal Medicine - January 9, 2019 Category: Internal Medicine Authors: Harigai M, Tsutsumino M, Takada H, Nagasaka K Tags: Korean J Intern Med Source Type: research