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Effect of Virtual Reality Simulation Versus Traditional Education on Rates of < em > Clostridium difficile < /em > Infection: An Experimental Cluster Randomized Controlled Trial and Return on Investment Analysis
CONCLUSION: Findings showed that VRS was an effective instructional method. [J Contin Educ Nurs. 202x;5x(x):xx-xx.].PMID:38466726 | DOI:10.3928/00220124-20240301-03 (Source: Journal of Continuing Education in Nursing)
Source: Journal of Continuing Education in Nursing - March 11, 2024 Category: Nursing Authors: Jessica M Phillips Mary G Harper Mary-Lynn Brecht Chia-Yen Li Holli A DeVon Source Type: research

Low-risk pneumatosis intestinalis in the pediatric surgical population
ConclusionsHere, we define low-risk PI as that which occurs in children over age 1 who do not have a prior diagnosis of cancer or prior BMT and who do not require ICU admission, vasopressor administration, or urgent surgical intervention. It is likely safe to treat these children with only 3 days of antibiotic therapy and NPO.Level of evidenceLevel III. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - March 11, 2024 Category: Surgery Source Type: research

On the use of intravenous metronidazole for severe and complicated < em > Clostridioides difficile < /em > infection: a review and meta-analysis
Infez Med. 2024 Mar 1;32(1):20-24. doi: 10.53854/liim-3201-3. eCollection 2024.ABSTRACTThe European Society of Clinical Microbiology and Infectious Disease (ESCMID) has advised against the use of metronidazole for fulminant Clostridioides difficile (C. difficile) infection (CDI) in their latest guidelines. They suggest using oral vancomycin alone instead. This recommendation is based on a few retrospective studies, which have multiple biases. We evaluated the three studies that led ESCMID to advise against intravenous metronidazole for fulminant CDI and performed a meta-analysis. The meta-analysis revealed a mild (2.7%), n...
Source: Infezioni in Medicina - March 8, 2024 Category: Infectious Diseases Authors: Giuseppe Pipitone Guido Granata Massimo Sartelli Andrea Gizzi Claudia Imburgia Laura Marsala Antonio Cascio Chiara Iaria Source Type: research

Biophysical library screening using a Thermo-FMN assay to identify and characterize Clostridioides difficile FabK inhibitors
Biochem Biophys Res Commun. 2024 Feb 29;705:149740. doi: 10.1016/j.bbrc.2024.149740. Online ahead of print.ABSTRACTClostridioides difficile, a gram-positive anaerobic bacterium, is one of the most frequent causes of nosocomial infections. C. difficile infection (CDI) results in almost a half a million infections and approximately 30,000 deaths in the U.S. each year. Broad-spectrum antibacterial use is a strong risk factor for development of recurring CDI. There is a critical need for narrow-spectrum antibacterials with activity limited to C. difficile. The C. difficile enoyl-acyl carrier protein (ACP) reductase II enzyme (...
Source: Biochemical and Biophysical Research communications - March 8, 2024 Category: Biochemistry Authors: Fahad Bin Aziz Pavel Glen E Palmer Kirk E Hevener Source Type: research