Clostridium Difficile Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Clinical Efficacy of Therapeutic Agents for Clostridioides difficile Infection Based on Four Severity Classifications
Jpn J Infect Dis. 2024 Mar 29. doi: 10.7883/yoken.JJID.2023.483. Online ahead of print.ABSTRACTThe Japanese guidelines for the management of Clostridioides difficile infection (CDI) recommend metronidazole (MNZ) for non-severe cases and vancomycin (VCM) for severe cases. Here, we investigated the use of CDI antimicrobials and evaluated their clinical efficacy in four severity classifications and the validity of these classifications. A retrospective chart review was conducted on 137 inpatients with an initial positive C. difficile toxin test and initiation of CDI antimicrobials between April 2015 and March 2019. For the cl...
Source: Japanese Journal of Infectious Diseases - March 31, 2024 Category: Infectious Diseases Authors: Mariko Ohtani Sadako Yoshizawa Taito Miyazaki Eri Kumade Shinobu Hirayama Maki Sakamoto Hinako Murakami Tadashi Maeda Yoshikazu Ishii Takahiro Matsumoto Kazuhiro Tateda Source Type: research

Approaching toxigenic Clostridia from a one health perspective
We present examples showing use of these resources in surveillance, including capacity to assess linkages among clinical, environmental, and foodborne reservoirs and to further research investigations into factors promoting their persistence and virulence in different settings.PMID:38552896 | DOI:10.1016/j.anaerobe.2024.102839 (Source: Anaerobe)
Source: Anaerobe - March 29, 2024 Category: Microbiology Authors: Laura M Cersosimo Jay N Worley Lynn Bry Source Type: research

Incidence of Colorectal Cancer After Intestinal Infection Due to Clostridioides difficile
CONCLUSIONS: This study shows a statistically significant correlation between CDI and decreased incidence of CRC. Additionally, there is a statistically significant correlation between obese patients with CDI and an increased incidence of CRC. Further research is needed to explore the mechanism of this striking relationship and the implications of CDIs on the microbiome.PMID:38545472 | PMC:PMC10965253 | DOI:10.14740/wjon1802 (Source: Cancer Control)
Source: Cancer Control - March 28, 2024 Category: Cancer & Oncology Authors: Raina K Patel Matthew Cardeiro Lexi Frankel Enoch Kim Kazuaki Takabe Omar M Rashid Source Type: research

Detection of Clostridioides difficile infection by assessment of exhaled breath volatile organic compounds
Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired infective diarrhea. Current methods for diagnosing CDI have limitations; enzyme immunoassays for toxin have low sensitivity and Clostridioides difficile polymerase chain reaction cannot differentiate infection from colonization. An ideal diagnostic test that incorporates microbial factors, host factors, and host-microbe interaction might characterize true infection. Assessing volatile organic compounds (VOCs) in exhaled breath may be a useful test for identifying CDI. To identify a wide selection of VOCs in exhaled breath, we used thermal de...
Source: Journal of Breath Research - March 28, 2024 Category: Respiratory Medicine Authors: Teny M John, Nabin K Shrestha, Leen Hasan, Kirk Pappan, Owen Birch, David Grove, Billy Boyle, Max Allsworth, Priyanka Shrestha, Gary W Procop and Raed A Dweik Source Type: research

Clostridium difficile Infection Prior to Total Hip Arthroplasty Independently Increases the Risk of Periprosthetic Joint Infection
Periprosthetic joint infection (PJI) following total hip arthroplasty (THA) is associated with major morbidity. There may be a link between the gut microbiome and an individual ’s overall immune system. A Clostridium difficile infection portends poor gut microbiome health and has been previously associated with increased 90-day complication rates in total joint arthroplasty (TJA). The purpose of this study was to determine the effect of a previous history of C. difficile infection within two years of undergoing THA on PJI within two years postoperatively. (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - March 26, 2024 Category: Orthopaedics Authors: David G. Deckey, Sayi P. Boddu, Jens T. Verhey, Stephen A. Doxey, Mark J. Spangehl, Henry D. Clarke, Joshua S. Bingham Tags: 2023 AAHKS Proceedings Source Type: research

< em > Clostridioides difficile < /em > detection and infection in children: are they just small adults?
J Med Microbiol. 2024 Mar;73(3). doi: 10.1099/jmm.0.001816.ABSTRACTClostridioides difficile is a well-recognized healthcare-associated pathogen, with its significance widely recognized in adult populations. Despite this, there is limited data on the significance of detection within paediatric populations, both for individual patient management and wider transmission risk-based considerations. High rates of colonization are understood to occur in infants, with increasing levels up to 11 months, and colonization rates similar to adults by 8 years old. Sources of C. difficile are ubiquitous, with detection in companion animal...
Source: Journal of Medical Microbiology - March 25, 2024 Category: Microbiology Authors: Sam Watkin Francis Yongblah James Burton John C Hartley Elaine Cloutman-Green Source Type: research