Lipid A modification-induced colistin-resistant < em > Klebsiella variicola < /em > from healthy adults
Conclusions. We found that colistin resistance in K. variicola was mediated by the modification of lipid A. Although the isolate was obtained from faecal samples of healthy adults, colistin-resistant K. variicola challenges public health as an opportunistic pathogen.PMID:37261959 | DOI:10.1099/jmm.0.001680 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - June 1, 2023 Category: Microbiology Authors: Sun Ju Kim Jeongwoo Jo Kwan Soo Ko Source Type: research
Unravelling the flexibility of < em > Mycobacterium tuberculosis: < /em > an escape way for the bacilli
J Med Microbiol. 2023 Jun;72(6). doi: 10.1099/jmm.0.001695.ABSTRACTThe persistence of Mycobacterium tuberculosis makes it difficult to eradicate the associated infection from the host. The flexible nature of mycobacteria and their ability to adapt to adverse host conditions give rise to different drug-tolerant phenotypes. Granuloma formation restricts nutrient supply, limits oxygen availability and exposes bacteria to a low pH environment, resulting in non-replicating bacteria. These non-replicating mycobacteria, which need high doses and long exposure to anti-tubercular drugs, are the root cause of lengthy chemotherapy. N...
Source: Journal of Medical Microbiology - June 1, 2023 Category: Microbiology Authors: Shashikanta Sau Arnab Roy Puja Kumari Agnivesh Sunil Kumar Santosh Kumar Guru Sandeep Sharma Nitin Pal Kalia Source Type: research
Enhanced monitoring of healthcare shower water in augmented and non-augmented care wards showing persistence of < em > Pseudomonas aeruginosa < /em > despite remediation work
Conclusions. We demonstrate the difficulties in eradicating P. aeruginosa from hospital plumbing, particularly when contamination is no longer sporadic. Non-augmented care settings are reservoirs of P. aeruginosa and should not be overlooked in outbreak investigations. Antimicrobial-impregnated materials may be ineffective once colonization with P. aeruginosa is established beyond the hose and head. Reducing hose-length insufficient to prevent cross-contamination from shower drains. P. aeruginosa colonization can be transient in both drain and shower hose/head. Frequent microbiological monitoring suggests testing frequenci...
Source: Journal of Medical Microbiology - May 31, 2023 Category: Microbiology Authors: Özge Yetiş Shanom Ali Kush Karia Paul Bassett Peter Wilson Source Type: research
Expansion of hantavirus infection during the SARS-CoV-2 pandemic in Bosnia and Herzegovina, 2021
Conclusion. The reported infections were probably caused by exposure of individuals to at-risk areas inhabited by contaminated rodents as natural reservoirs of hantavirus. As a highly endemic area, B and H requires continuous monitoring and increased awareness of this problem.PMID:37255412 | DOI:10.1099/jmm.0.001687 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - May 31, 2023 Category: Microbiology Authors: Irma Salimovi ć-Bešić Semir Hrvo Edina Zahirovi ć El-Jesah Đulić Rusmir Balji ć Amela Dedei ć-Ljubović Source Type: research
Enhanced monitoring of healthcare shower water in augmented and non-augmented care wards showing persistence of < em > Pseudomonas aeruginosa < /em > despite remediation work
Conclusions. We demonstrate the difficulties in eradicating P. aeruginosa from hospital plumbing, particularly when contamination is no longer sporadic. Non-augmented care settings are reservoirs of P. aeruginosa and should not be overlooked in outbreak investigations. Antimicrobial-impregnated materials may be ineffective once colonization with P. aeruginosa is established beyond the hose and head. Reducing hose-length insufficient to prevent cross-contamination from shower drains. P. aeruginosa colonization can be transient in both drain and shower hose/head. Frequent microbiological monitoring suggests testing frequenci...
Source: Journal of Medical Microbiology - May 31, 2023 Category: Microbiology Authors: Özge Yetiş Shanom Ali Kush Karia Paul Bassett Peter Wilson Source Type: research
Expansion of hantavirus infection during the SARS-CoV-2 pandemic in Bosnia and Herzegovina, 2021
Conclusion. The reported infections were probably caused by exposure of individuals to at-risk areas inhabited by contaminated rodents as natural reservoirs of hantavirus. As a highly endemic area, B and H requires continuous monitoring and increased awareness of this problem.PMID:37255412 | DOI:10.1099/jmm.0.001687 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - May 31, 2023 Category: Microbiology Authors: Irma Salimovi ć-Bešić Semir Hrvo Edina Zahirovi ć El-Jesah Đulić Rusmir Balji ć Amela Dedei ć-Ljubović Source Type: research
Direct monitoring of meropenem therapeutic efficacy against < em > Klebsiella pneumoniae < /em > respiratory infection by bioluminescence imaging
Conclusion. The use of non-invasive bioluminescent imaging improves preclinical animal model testing to detect study outcome earlier and with higher sensitivity.PMID:37252851 | DOI:10.1099/jmm.0.001686 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - May 30, 2023 Category: Microbiology Authors: Ramy A Fodah Jacob B Scott Jonathan M Warawa Source Type: research
Direct monitoring of meropenem therapeutic efficacy against < em > Klebsiella pneumoniae < /em > respiratory infection by bioluminescence imaging
Conclusion. The use of non-invasive bioluminescent imaging improves preclinical animal model testing to detect study outcome earlier and with higher sensitivity.PMID:37252851 | DOI:10.1099/jmm.0.001686 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - May 30, 2023 Category: Microbiology Authors: Ramy A Fodah Jacob B Scott Jonathan M Warawa Source Type: research
Anti-tumour effect of Huangqin Decoction on colorectal cancer mice through microbial butyrate mediated PI3K/Akt pathway suppression
Conclusion. Overall, in this study, we revealed that HQD could induce apoptosis through microbial butyrate mediated PI3K/Akt inhibition and perform anti-CRC activity.PMID:37195736 | DOI:10.1099/jmm.0.001692 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - May 17, 2023 Category: Microbiology Authors: Jia-Jie Zhu Hai-Yan Liu Liang-Jun Yang Zheng Fang Rui Fu Jia-Bin Chen Shan Liu Bao-Ying Fei Source Type: research
Implication of COVID-19 pandemic on the incidence of < em > Clostridioides difficile < /em > infection in a Greek tertiary hospital
Conclusion. A significant increase of CDI incidence was observed, with the rate of the rise being more intense during the COVID-19 pandemic.PMID:37195744 | DOI:10.1099/jmm.0.001689 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - May 17, 2023 Category: Microbiology Authors: Theodoros Karampatakis Katerina Tsergouli Eleni Kandilioti Anna Nikopoulou Helen Katsifa Melina Kachrimanidou Source Type: research
Genomic features and virulence characteristics of a rare < em > Burkholderia thailandensis < /em > strain causing human infection
Conclusion. Taken together, the results of this study provide basic information on the genomic features and virulence characteristics of the virulent B. thailandensis strain BPM, which is helpful for understanding its evolution as it relates to pathogenesis and environmental adaptability.PMID:37195748 | DOI:10.1099/jmm.0.001688 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - May 17, 2023 Category: Microbiology Authors: Jin Li Qiu Zhong Jian Li Hui-Min Chong Li-Xin Wang Yun Xing Wei-Ping Lu Source Type: research
Anti-chlamydial effects of azelastine hydrochloride and the impact of the histamine H1 receptor on chlamydial development
Conclusion. Accordingly, we conclude that azelastine anti-chlamydial effects are not restricted to a specific chlamydial species, strain or culture model, and are probably not mediated by H1R antagonism. Thus, it appears likely that off-target mechanisms of azelastine may explain our observations.PMID:37195751 | DOI:10.1099/jmm.0.001691 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - May 17, 2023 Category: Microbiology Authors: Jasmin Kuratli Cory Ann Leonard Robert Schoborg Nicole Borel Source Type: research
Anti-tumour effect of Huangqin Decoction on colorectal cancer mice through microbial butyrate mediated PI3K/Akt pathway suppression
Conclusion. Overall, in this study, we revealed that HQD could induce apoptosis through microbial butyrate mediated PI3K/Akt inhibition and perform anti-CRC activity.PMID:37195736 | DOI:10.1099/jmm.0.001692 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - May 17, 2023 Category: Microbiology Authors: Jia-Jie Zhu Hai-Yan Liu Liang-Jun Yang Zheng Fang Rui Fu Jia-Bin Chen Shan Liu Bao-Ying Fei Source Type: research
Implication of COVID-19 pandemic on the incidence of < em > Clostridioides difficile < /em > infection in a Greek tertiary hospital
Conclusion. A significant increase of CDI incidence was observed, with the rate of the rise being more intense during the COVID-19 pandemic.PMID:37195744 | DOI:10.1099/jmm.0.001689 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - May 17, 2023 Category: Microbiology Authors: Theodoros Karampatakis Katerina Tsergouli Eleni Kandilioti Anna Nikopoulou Helen Katsifa Melina Kachrimanidou Source Type: research
Genomic features and virulence characteristics of a rare < em > Burkholderia thailandensis < /em > strain causing human infection
Conclusion. Taken together, the results of this study provide basic information on the genomic features and virulence characteristics of the virulent B. thailandensis strain BPM, which is helpful for understanding its evolution as it relates to pathogenesis and environmental adaptability.PMID:37195748 | DOI:10.1099/jmm.0.001688 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - May 17, 2023 Category: Microbiology Authors: Jin Li Qiu Zhong Jian Li Hui-Min Chong Li-Xin Wang Yun Xing Wei-Ping Lu Source Type: research
