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Evaluation of anti-biofilm effect of antimicrobial sonodynamic therapy-based periodontal ligament stem cell-derived exosome-loaded kojic acid on Enterococcus faecalis biofilm
Conclusion. The KA@PDL-Exo-mediated aSDT was able to significantly reduce the E. faecalis load in pre-formed biofilms, decrease the expression of gelE and srpE mRNA, and increase the generation of endogenous ROS. These findings imply that KA@PDL-Exo-mediated aSDT could be a promising anti-biofilm strategy that requires additional in vitro and in vivo investigations.PMID:37910015 | DOI:10.1099/jmm.0.001772 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - November 1, 2023 Category: Microbiology Authors: Maryam Pourhajibagher Maryam Azimi Mohammadabadi Hassan-Ali Ghafari Mahshid Hodjat Abbas Bahador Source Type: research

Genomic analyses of Bacteroides fragilis : subdivisions I and II represent distinct species
Conclusion. The findings indicate that B. fragilis A, previously referred to as division II B. fragilis, is an individual species and distinct from B. fragilis sensu stricto. The B. fragilis pangenome analysis supported previous genomic, phylogenetic and resistome screening analyses collectively reinforcing that divisions I and II are two separate species. In addition, it was confirmed that differences in the accessory genes of B. fragilis divisions I and II are primarily associated with carbohydrate metabolism and suggest that differences other than antimicrobial resistance could also be used to distinguish between these ...
Source: Journal of Medical Microbiology - November 1, 2023 Category: Microbiology Authors: Jamie English Fiona Newberry Lesley Hoyles Sheila Patrick Linda Stewart Source Type: research

Explore intersection genes of oxymatrine and COVID-19 with lung cancer as potential therapeutic targets based on network pharmacology
Conclusion. To treat COVID-19 or lung cancer paired with COVID-19, oxymatrine may improve the therapeutic efficacy of current clinical antiviral medicines and immunotherapy.PMID:37855710 | DOI:10.1099/jmm.0.001766 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - October 19, 2023 Category: Microbiology Authors: Wei Wu Chuan Cheng Dongdong Yuan Li Peng Le Li Source Type: research

Molecular mechanism of Enteroaggregative Escherichia coli induced apoptosis in cultured human intestinal epithelial cells
J Med Microbiol. 2023 Oct;72(10). doi: 10.1099/jmm.0.001760.ABSTRACTBackground. Enteroaggregative Escherichia coli (EAEC) is an evolving etiological agent of acute and persistent diarrhoea worldwide. The previous study from our laboratory has reported the apoptosis-inducing activity of EAEC in human small intestinal and colonic epithelial cell lines. In the present investigation, we have explored the underlying mechanism of EAEC-induced apoptosis in human intestinal epithelial cell lines.Methods. INT-407 and HCT-15 cells were infected with EAEC-T8 and EAEC-pT8 (plasmid cured strain of EAEC-T8) separately. Cells cultured in...
Source: Journal of Medical Microbiology - October 17, 2023 Category: Microbiology Authors: Anshu Priya Shipra Chandel Archana Joon Sujata Ghosh Source Type: research

Corrigendum: Direct monitoring of meropenem therapeutic efficacy against Klebsiella pneumoniae respiratory infection by bioluminescence imaging
J Med Microbiol. 2023 Oct;72(10). doi: 10.1099/jmm.0.001765.NO ABSTRACTPMID:37846970 | DOI:10.1099/jmm.0.001765 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - October 17, 2023 Category: Microbiology Authors: Ramy A Fodah Jacob B Scott Jonathan M Warawa Source Type: research