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Multi-drug-resistant tuberculosis and its associated factors among pulmonary tuberculosis patients linked to first-line anti-tuberculosis drugs in north-west Ethiopia
Conclusion. The prevalence of MDR-TB was high (9.3 %) and contributed highly to new cases (8.3 %). Factors associated with MDR-TB were previous treatment, co-morbidity and laboratory diagnosis method prior to TB treatment. Therefore, this finding aims to maximize early detection and treatment, strengthening TB infection control, and proper implementation of directly observed therapy short course recommendations to reduce the burden of MDR-TB.PMID:38099651 | DOI:10.1099/jmm.0.001775 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - December 15, 2023 Category: Microbiology Authors: Mulat Erkihun Teklehaimanot Kiros Ayenew Berhan Bayu Ayele Source Type: research

Engineering of the LAMP-CRISPR/Cas12b platform for < em > Chlamydia psittaci < /em > detection
Conclusions. The LAMP-CRISPR/Cas12b assay developed in this study provides a sensitive and specific method for rapidly detecting C. psittaci and offers technical support for its rapid diagnosis.PMID:38054656 | DOI:10.1099/jmm.0.001781 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - December 6, 2023 Category: Microbiology Authors: Rong Wang Xujian Mao Jian Xu Ping Yao Jingyi Jiang Qiong Li Fengming Wang Source Type: research

Mixture modelling of < em > Bordetella pertussis < /em > serology samples to evaluate anti-pertussis toxin immunoglobulin G titre thresholds for positivity: England 2008-2022
Conclusion. Mixture modelling is a useful tool to establish thresholds, but reassessment should also be done when there have been changes to prevalence and/or testing regimes to determine whether there have been any changes in sensitivity, specificity, PPV, and NPV and whether the threshold should be revised.PMID:38047762 | DOI:10.1099/jmm.0.001774 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - December 4, 2023 Category: Microbiology Authors: Elise Tessier David Litt Sonia Ribeiro Nurin Abdul Aziz Helen Campbell Gayatri Amirthalingam Norman K Fry Nick Andrews Source Type: research

Saliva sampling and its direct lysis is an excellent option for SARS-CoV-2 diagnosis in paediatric patients: comparison with the PanBio COVID-19 antigen rapid test in symptomatic and asymptomatic children
Conclusion. Our data highlight the benefits of using RT-qPCR and saliva samples for SARS-CoV-2 detection, particularly in paediatric patients.PMID:38014762 | DOI:10.1099/jmm.0.001779 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - November 28, 2023 Category: Microbiology Authors: Joaqu ín Moreno-Contreras Marco A Espinoza Marco A Cant ú-Cuevas Daniel A Madrid-Gonz ález H éctor Barón-Olivares Oscar D Ortiz-Orozco Cecilia Guzm án-Rodríguez Carlos F Arias Susana Lopez Source Type: research

The changes of gut microbiota and metabolites in different drug-induced liver injuries
J Med Microbiol. 2023 Nov;72(11). doi: 10.1099/jmm.0.001778.ABSTRACTThe increasing incidence of drug-induced liver injury (DILI) has become a major concern. Gut microbiota, as another organ of the human body, has been studied in various tumors, cardiovascular metabolic diseases, inflammatory bowel disease and human immunity. The studies mentioned above have confirmed its important impact on the occurrence and development of DILI. The gut-liver axis explains the close relationship between the gut and the liver, and it may be a pathway by which gut microbes contribute to DILI. In addition, the interaction between drugs and g...
Source: Journal of Medical Microbiology - November 28, 2023 Category: Microbiology Authors: Ruirui Zhu Yinghui Gao Jianxia Dong Zhiqin Li Zhigang Ren Source Type: research