< em > Clostridioides difficile < /em > toxins enhanced the < em > in vitro < /em > production of CXC chemokine ligand 2 and tumor necrosis factor- α via Toll-like receptors in macrophages
Conclusion. Our results showed that C. difficile toxins, including CDT, enhanced macrophage-mediated CXCL2 and TNF-α production via TLR2 and TLR4, indicating that CDT affects host immune responses.PMID:33830910 | DOI:10.1099/jmm.0.001342 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 8, 2021 Category: Microbiology Authors: Hiroe Konishi McKee Chiaki Kajiwara Tetsuo Yamaguchi Yoshikazu Ishii Norikazu Shimizu Akira Ohara Kazuhiro Tateda Source Type: research

An antipathogenic compound that targets the OxyR peroxide sensor in < em > Pseudomonas aeruginosa < /em >
Conclusion. These results suggest that compound 1 could be an antipathogenic hit inhibiting the P. aeruginosa OxyR. More importantly, our study provides an insight into the computer-based discovery of new-paradigm selective antibacterials to treat Gram-negative bacterial infections presumably with few concerns of drug resistance.PMID:33830911 | DOI:10.1099/jmm.0.001341 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - April 8, 2021 Category: Microbiology Authors: Hyo-Young Oh Shivakumar S Jalde In-Young Chung Yeon-Ji Yoo Hye-Jeong Jang Hyun-Kyung Choi You-Hee Cho Source Type: research

Antimicrobial resistance and multilocus sequence types of < em > Stenotrophomonas maltophilia < /em > isolated from dogs and cats in Japan
J Med Microbiol. 2021 Apr;70(4). doi: 10.1099/jmm.0.001344.ABSTRACTAs the representative multidrug-resistant pathogen, Stenotrophomonas maltophilia has multiple intrinsic and acquired resistances, including carbapenem resistance. In companion animals, the antimicrobial susceptibility and sequence types (STs) of S. maltophilia are not well understood due to its limited isolation rate. We investigated the antimicrobial susceptibilities and multilocus sequence types (MLSTs) of 38 S. maltophilia strains isolated from dogs and cats in Japan. Prevalence of resistance was detected for imipenem (100 %), aztreonam (94.7 %), piperac...
Source: Journal of Medical Microbiology - April 7, 2021 Category: Microbiology Authors: Takae Shimizu Yuzo Tsuyuki Kenta Shimoike Keita Iyori Tadashi Miyamoto Kazuki Harada Source Type: research

Antimicrobial resistance and multilocus sequence types of < em > Stenotrophomonas maltophilia < /em > isolated from dogs and cats in Japan
J Med Microbiol. 2021 Apr;70(4). doi: 10.1099/jmm.0.001344.ABSTRACTAs the representative multidrug-resistant pathogen, Stenotrophomonas maltophilia has multiple intrinsic and acquired resistances, including carbapenem resistance. In companion animals, the antimicrobial susceptibility and sequence types (STs) of S. maltophilia are not well understood due to its limited isolation rate. We investigated the antimicrobial susceptibilities and multilocus sequence types (MLSTs) of 38 S. maltophilia strains isolated from dogs and cats in Japan. Prevalence of resistance was detected for imipenem (100 %), aztreonam (94.7 %), piperac...
Source: Journal of Medical Microbiology - April 7, 2021 Category: Microbiology Authors: Takae Shimizu Yuzo Tsuyuki Kenta Shimoike Keita Iyori Tadashi Miyamoto Kazuki Harada Source Type: research

Introducing JMM Profiles for the < em > Journal of Medical Microbiology < /em >
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001296. Epub 2021 Mar 23.NO ABSTRACTPMID:33759740 | DOI:10.1099/jmm.0.001296 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Norman K Fry Source Type: research

JMM Profile: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001336. Epub 2021 Mar 23.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the cause of an infection known as coronavirus infectious disease 2019 (COVID-19). COVID-19 has become a global source of morbidity, mortality and social disruption since its emergence in East Asia in late 2019 and subsequent pandemic spread. Typical symptoms include cough, sore throat, fever, and sudden loss of taste and smell. Persistent, post-infection sequelae have been noted in a minority of cases. Severe complications and deaths occur mostly in older adults. La...
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Timothy J J Inglis Kalai Mathee Source Type: research

Introducing JMM Profiles for the < em > Journal of Medical Microbiology < /em >
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001296. Epub 2021 Mar 23.NO ABSTRACTPMID:33759740 | DOI:10.1099/jmm.0.001296 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Norman K Fry Source Type: research

JMM Profile: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001336. Epub 2021 Mar 23.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the cause of an infection known as coronavirus infectious disease 2019 (COVID-19). COVID-19 has become a global source of morbidity, mortality and social disruption since its emergence in East Asia in late 2019 and subsequent pandemic spread. Typical symptoms include cough, sore throat, fever, and sudden loss of taste and smell. Persistent, post-infection sequelae have been noted in a minority of cases. Severe complications and deaths occur mostly in older adults. La...
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Timothy J J Inglis Kalai Mathee Source Type: research

Introducing JMM Profiles for the < em > Journal of Medical Microbiology < /em >
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001296. Epub 2021 Mar 23.NO ABSTRACTPMID:33759740 | DOI:10.1099/jmm.0.001296 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Norman K Fry Source Type: research

JMM Profile: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001336. Epub 2021 Mar 23.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the cause of an infection known as coronavirus infectious disease 2019 (COVID-19). COVID-19 has become a global source of morbidity, mortality and social disruption since its emergence in East Asia in late 2019 and subsequent pandemic spread. Typical symptoms include cough, sore throat, fever, and sudden loss of taste and smell. Persistent, post-infection sequelae have been noted in a minority of cases. Severe complications and deaths occur mostly in older adults. La...
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Timothy J J Inglis Kalai Mathee Source Type: research

Introducing JMM Profiles for the < em > Journal of Medical Microbiology < /em >
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001296. Epub 2021 Mar 23.NO ABSTRACTPMID:33759740 | DOI:10.1099/jmm.0.001296 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Norman K Fry Source Type: research

JMM Profile: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001336. Epub 2021 Mar 23.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the cause of an infection known as coronavirus infectious disease 2019 (COVID-19). COVID-19 has become a global source of morbidity, mortality and social disruption since its emergence in East Asia in late 2019 and subsequent pandemic spread. Typical symptoms include cough, sore throat, fever, and sudden loss of taste and smell. Persistent, post-infection sequelae have been noted in a minority of cases. Severe complications and deaths occur mostly in older adults. La...
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Timothy J J Inglis Kalai Mathee Source Type: research

Introducing JMM Profiles for the < em > Journal of Medical Microbiology < /em >
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001296. Epub 2021 Mar 23.NO ABSTRACTPMID:33759740 | DOI:10.1099/jmm.0.001296 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Norman K Fry Source Type: research

JMM Profile: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001336. Epub 2021 Mar 23.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the cause of an infection known as coronavirus infectious disease 2019 (COVID-19). COVID-19 has become a global source of morbidity, mortality and social disruption since its emergence in East Asia in late 2019 and subsequent pandemic spread. Typical symptoms include cough, sore throat, fever, and sudden loss of taste and smell. Persistent, post-infection sequelae have been noted in a minority of cases. Severe complications and deaths occur mostly in older adults. La...
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Timothy J J Inglis Kalai Mathee Source Type: research

Introducing JMM Profiles for the < em > Journal of Medical Microbiology < /em >
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001296. Epub 2021 Mar 23.NO ABSTRACTPMID:33759740 | DOI:10.1099/jmm.0.001296 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Norman K Fry Source Type: research

JMM Profile: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001336. Epub 2021 Mar 23.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the cause of an infection known as coronavirus infectious disease 2019 (COVID-19). COVID-19 has become a global source of morbidity, mortality and social disruption since its emergence in East Asia in late 2019 and subsequent pandemic spread. Typical symptoms include cough, sore throat, fever, and sudden loss of taste and smell. Persistent, post-infection sequelae have been noted in a minority of cases. Severe complications and deaths occur mostly in older adults. La...
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Timothy J J Inglis Kalai Mathee Source Type: research

Introducing JMM Profiles for the < em > Journal of Medical Microbiology < /em >
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001296.NO ABSTRACTPMID:33759740 | DOI:10.1099/jmm.0.001296 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Norman K Fry Source Type: research

JMM Profile: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001336.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the cause of an infection known as coronavirus infectious disease 2019 (COVID-19). COVID-19 has become a global source of morbidity, mortality and social disruption since its emergence in East Asia in late 2019 and subsequent pandemic spread. Typical symptoms include cough, sore throat, fever, and sudden loss of taste and smell. Persistent, post-infection sequelae have been noted in a minority of cases. Severe complications and deaths occur mostly in older adults. Laboratory confirmat...
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Timothy J J Inglis Kalai Mathee Source Type: research

Introducing JMM Profiles for the < em > Journal of Medical Microbiology < /em >
J Med Microbiol. 2021 Mar 24. doi: 10.1099/jmm.0.001296. Online ahead of print.NO ABSTRACTPMID:33759740 | DOI:10.1099/jmm.0.001296 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Norman K Fry Source Type: research

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
J Med Microbiol. 2021 Mar 24. doi: 10.1099/jmm.0.001336. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the cause of an infection known as coronavirus infectious disease 2019 (COVID-19). COVID-19 has become a global source of morbidity, mortality and social disruption since its emergence in East Asia in late 2019 and subsequent pandemic spread. Typical symptoms include cough, sore throat, fever, and sudden loss of taste and smell. Persistent, post-infection sequelae have been noted in a minority of cases. Severe complications and deaths occur mostly in older adults. ...
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Timothy J J Inglis Kalai Mathee Source Type: research

Introducing JMM Profiles for the < em > Journal of Medical Microbiology < /em >
J Med Microbiol. 2021 Mar 24. doi: 10.1099/jmm.0.001296. Online ahead of print.NO ABSTRACTPMID:33759740 | DOI:10.1099/jmm.0.001296 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Norman K Fry Source Type: research

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
J Med Microbiol. 2021 Mar 24. doi: 10.1099/jmm.0.001336. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the cause of an infection known as coronavirus infectious disease 2019 (COVID-19). COVID-19 has become a global source of morbidity, mortality and social disruption since its emergence in East Asia in late 2019 and subsequent pandemic spread. Typical symptoms include cough, sore throat, fever, and sudden loss of taste and smell. Persistent, post-infection sequelae have been noted in a minority of cases. Severe complications and deaths occur mostly in older adults. ...
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Timothy J J Inglis Kalai Mathee Source Type: research

Introducing JMM Profiles for the < em > Journal of Medical Microbiology < /em >
J Med Microbiol. 2021 Mar 24. doi: 10.1099/jmm.0.001296. Online ahead of print.NO ABSTRACTPMID:33759740 | DOI:10.1099/jmm.0.001296 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Norman K Fry Source Type: research

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
J Med Microbiol. 2021 Mar 24. doi: 10.1099/jmm.0.001336. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the cause of an infection known as coronavirus infectious disease 2019 (COVID-19). COVID-19 has become a global source of morbidity, mortality and social disruption since its emergence in East Asia in late 2019 and subsequent pandemic spread. Typical symptoms include cough, sore throat, fever, and sudden loss of taste and smell. Persistent, post-infection sequelae have been noted in a minority of cases. Severe complications and deaths occur mostly in older adults. ...
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Timothy J J Inglis Kalai Mathee Source Type: research

Introducing JMM Profiles for the < em > Journal of Medical Microbiology < /em >
J Med Microbiol. 2021 Mar 24. doi: 10.1099/jmm.0.001296. Online ahead of print.NO ABSTRACTPMID:33759740 | DOI:10.1099/jmm.0.001296 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Norman K Fry Source Type: research

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
J Med Microbiol. 2021 Mar 24. doi: 10.1099/jmm.0.001336. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is the cause of an infection known as coronavirus infectious disease 2019 (COVID-19). COVID-19 has become a global source of morbidity, mortality and social disruption since its emergence in East Asia in late 2019 and subsequent pandemic spread. Typical symptoms include cough, sore throat, fever, and sudden loss of taste and smell. Persistent, post-infection sequelae have been noted in a minority of cases. Severe complications and deaths occur mostly in older adults. ...
Source: Journal of Medical Microbiology - March 24, 2021 Category: Microbiology Authors: Timothy J J Inglis Kalai Mathee Source Type: research

Pathogenicity and drug resistance of animal streptococci responsible for human infections
J Med Microbiol. 2021 Mar 22. doi: 10.1099/jmm.0.001339. Online ahead of print.ABSTRACTBacteria of the genus Streptococcus, earlier considered typically animal, currently have also been causing infections in humans. It is necessary to make clinicians aware of the emergence of new species that may cause the development of human diseases. There is an increasing frequency of isolation of streptococci such as S. suis, S. dysgalactiae, S. iniae and S. equi from people. Isolation of Streptococcus bovis/Streptococcus equinus complex bacteria has also been reported. The streptococcal species described in this review are gaining ne...
Source: Journal of Medical Microbiology - March 22, 2021 Category: Microbiology Authors: Paulina Glajzner Eligia Maria Szewczyk Magdalena Szemraj Source Type: research

Comparative study of multidrug-resistant < em > Enterococcus faecium < /em > obtained from different hosts
Conclusion. The level and range of antimicrobial resistance and the panel of resistance determinants is comparable between E. faecium isolates, despite host species.PMID:33750516 | DOI:10.1099/jmm.0.001340 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 22, 2021 Category: Microbiology Authors: Aleksandra Tro ściańczyk Aneta Nowakiewicz Sebastian Gnat Dominik Łagowski Marcelina Osi ńska Beata Chudzik-Rz ąd Source Type: research

Pathogenicity and drug resistance of animal streptococci responsible for human infections
J Med Microbiol. 2021 Mar 22. doi: 10.1099/jmm.0.001339. Online ahead of print.ABSTRACTBacteria of the genus Streptococcus, earlier considered typically animal, currently have also been causing infections in humans. It is necessary to make clinicians aware of the emergence of new species that may cause the development of human diseases. There is an increasing frequency of isolation of streptococci such as S. suis, S. dysgalactiae, S. iniae and S. equi from people. Isolation of Streptococcus bovis/Streptococcus equinus complex bacteria has also been reported. The streptococcal species described in this review are gaining ne...
Source: Journal of Medical Microbiology - March 22, 2021 Category: Microbiology Authors: Paulina Glajzner Eligia Maria Szewczyk Magdalena Szemraj Source Type: research

Comparative study of multidrug-resistant < em > Enterococcus faecium < /em > obtained from different hosts
Conclusion. The level and range of antimicrobial resistance and the panel of resistance determinants is comparable between E. faecium isolates, despite host species.PMID:33750516 | DOI:10.1099/jmm.0.001340 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 22, 2021 Category: Microbiology Authors: Aleksandra Tro ściańczyk Aneta Nowakiewicz Sebastian Gnat Dominik Łagowski Marcelina Osi ńska Beata Chudzik-Rz ąd Source Type: research

Adaptations of carbapenem resistant < em > Acinetobacter baumannii < /em > (CRAB) in the hospital environment causing sustained outbreak
J Med Microbiol. 2021 Mar 19. doi: 10.1099/jmm.0.001345. Online ahead of print.ABSTRACTIntroduction. Carbapenem resistance in Acinetobacter baumannii (A. baumannii) is an emerging global threat.Gap statement. The adaptation strategies of A. baumannii for this emergence as a nosocomial pathogen has been less studied.Aim. This prospective study analysed a sustained outbreak of carbapenem resistant Acinetobacter baumannii (CRAB) in the intensive care unit (ICU) with reference to antimicrobial resistance and virulence in the colonizing and pathogenic isolates under carbapenem stress.Results. The CRAB isolates from initial and ...
Source: Journal of Medical Microbiology - March 19, 2021 Category: Microbiology Authors: Swati Sharma Arghya Das Tuhina Banerjee Hiranmay Barman Ghanshyam Yadav Ashok Kumar Source Type: research

Adaptations of carbapenem resistant < em > Acinetobacter baumannii < /em > (CRAB) in the hospital environment causing sustained outbreak
J Med Microbiol. 2021 Mar 19. doi: 10.1099/jmm.0.001345. Online ahead of print.ABSTRACTIntroduction. Carbapenem resistance in Acinetobacter baumannii (A. baumannii) is an emerging global threat.Gap statement. The adaptation strategies of A. baumannii for this emergence as a nosocomial pathogen has been less studied.Aim. This prospective study analysed a sustained outbreak of carbapenem resistant Acinetobacter baumannii (CRAB) in the intensive care unit (ICU) with reference to antimicrobial resistance and virulence in the colonizing and pathogenic isolates under carbapenem stress.Results. The CRAB isolates from initial and ...
Source: Journal of Medical Microbiology - March 19, 2021 Category: Microbiology Authors: Swati Sharma Arghya Das Tuhina Banerjee Hiranmay Barman Ghanshyam Yadav Ashok Kumar Source Type: research

Adaptations of carbapenem resistant < em > Acinetobacter baumannii < /em > (CRAB) in the hospital environment causing sustained outbreak
J Med Microbiol. 2021 Mar 19. doi: 10.1099/jmm.0.001345. Online ahead of print.ABSTRACTIntroduction. Carbapenem resistance in Acinetobacter baumannii (A. baumannii) is an emerging global threat.Gap statement. The adaptation strategies of A. baumannii for this emergence as a nosocomial pathogen has been less studied.Aim. This prospective study analysed a sustained outbreak of carbapenem resistant Acinetobacter baumannii (CRAB) in the intensive care unit (ICU) with reference to antimicrobial resistance and virulence in the colonizing and pathogenic isolates under carbapenem stress.Results. The CRAB isolates from initial and ...
Source: Journal of Medical Microbiology - March 19, 2021 Category: Microbiology Authors: Swati Sharma Arghya Das Tuhina Banerjee Hiranmay Barman Ghanshyam Yadav Ashok Kumar Source Type: research

Immunomodulatory streptococci that inhibit CXCL8 secretion and NF κB activation are common members of the oral microbiota
Conclusion. Many streptococci isolated from plaque suppressed epithelial cell CXCL8 secretion, via inhibition of NFκB. This phenomenon may play an important role in oral host-microbe homeostasis.PMID:33734952 | DOI:10.1099/jmm.0.001329 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 18, 2021 Category: Microbiology Authors: Sarah Myers Thuy Do Josephine L Meade Aradhna Tugnait Jon J Vernon Jelena Pistolic Robert E W Hancock Philip D Marsh Harsh M Trivedi Dandan Chen Deirdre A Devine Source Type: research

Clinical relevance and antimicrobial susceptibility profile of the unknown human pathogen < em > Corynebacterium aurimucosum < /em >
Conclusion. C. aurimucosum should be considered as an actual opportunistic pathogen, and treatment with amoxicillin, vancomycin or linezolid should be preferred.PMID:33734955 | DOI:10.1099/jmm.0.001334 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 18, 2021 Category: Microbiology Authors: Charles R Lef èvre Romain Pelletier Alban Le Monnier St éphane Corvec Emmanuelle Bille Ana ïs Potron Vincent Fihman Eric Farfour Marl ène Amara Nicolas Degand Olivier Barraud Vincent Cattoir None For The Gmc Study Group Source Type: research

Comparative effects of viral-transport-medium heat inactivation upon downstream SARS-CoV-2 detection in patient samples
J Med Microbiol. 2021 Mar 18. doi: 10.1099/jmm.0.001301. Online ahead of print.ABSTRACTIntroduction. The COVID-19 pandemic, which began in 2020 is testing economic resilience and surge capacity of healthcare providers worldwide. At the time of writing, positive detection of the SARS-CoV-2 virus remains the only method for diagnosing COVID-19 infection. Rapid upscaling of national SARS-CoV-2 genome testing presented challenges: (1) Unpredictable supply chains of reagents and kits for virus inactivation, RNA extraction and PCR-detection of viral genomes. (2) Rapid time to result of
Source: Journal of Medical Microbiology - March 18, 2021 Category: Microbiology Authors: Jamie L Thompson Angela Downie Ruiz Velasco Alice Cardall Rebecca Tarbox Jaineeta Richardson Gemma Clarke Michelle Lister Hannah C Howson-Wells Vicki M Fleming Manjinder Khakh Tim Sloan Nichola Duckworth Sarah Walsh Chris Denning C Patrick McClure Andrew Source Type: research

Profile of specific antibodies to the SARS-CoV-2
J Med Microbiol. 2021 Mar 18. doi: 10.1099/jmm.0.001335. Online ahead of print.ABSTRACTIn this work, we studied the profile of IgM and IgG antibody responses to SARS-CoV-2 in 32 patients with COVID-19 from day 1 to day 24. IgM remained measurable for a much shorter period than IgG, suggesting that IgG antibody may represent the primary immune response.PMID:33734961 | DOI:10.1099/jmm.0.001335 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 18, 2021 Category: Microbiology Authors: Danlei Mou Huahua Feng Ruiyuan Cao Xing Weng Lizhe Zhao Lingling Yang Ronghua Jin Weijun Chen Source Type: research

Immunomodulatory streptococci that inhibit CXCL8 secretion and NF κB activation are common members of the oral microbiota
Conclusion. Many streptococci isolated from plaque suppressed epithelial cell CXCL8 secretion, via inhibition of NFκB. This phenomenon may play an important role in oral host-microbe homeostasis.PMID:33734952 | DOI:10.1099/jmm.0.001329 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 18, 2021 Category: Microbiology Authors: Sarah Myers Thuy Do Josephine L Meade Aradhna Tugnait Jon J Vernon Jelena Pistolic Robert E W Hancock Philip D Marsh Harsh M Trivedi Dandan Chen Deirdre A Devine Source Type: research

Clinical relevance and antimicrobial susceptibility profile of the unknown human pathogen < em > Corynebacterium aurimucosum < /em >
Conclusion. C. aurimucosum should be considered as an actual opportunistic pathogen, and treatment with amoxicillin, vancomycin or linezolid should be preferred.PMID:33734955 | DOI:10.1099/jmm.0.001334 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 18, 2021 Category: Microbiology Authors: Charles R Lef èvre Romain Pelletier Alban Le Monnier St éphane Corvec Emmanuelle Bille Ana ïs Potron Vincent Fihman Eric Farfour Marl ène Amara Nicolas Degand Olivier Barraud Vincent Cattoir None For The Gmc Study Group Source Type: research

Comparative effects of viral-transport-medium heat inactivation upon downstream SARS-CoV-2 detection in patient samples
J Med Microbiol. 2021 Mar 18. doi: 10.1099/jmm.0.001301. Online ahead of print.ABSTRACTIntroduction. The COVID-19 pandemic, which began in 2020 is testing economic resilience and surge capacity of healthcare providers worldwide. At the time of writing, positive detection of the SARS-CoV-2 virus remains the only method for diagnosing COVID-19 infection. Rapid upscaling of national SARS-CoV-2 genome testing presented challenges: (1) Unpredictable supply chains of reagents and kits for virus inactivation, RNA extraction and PCR-detection of viral genomes. (2) Rapid time to result of
Source: Journal of Medical Microbiology - March 18, 2021 Category: Microbiology Authors: Jamie L Thompson Angela Downie Ruiz Velasco Alice Cardall Rebecca Tarbox Jaineeta Richardson Gemma Clarke Michelle Lister Hannah C Howson-Wells Vicki M Fleming Manjinder Khakh Tim Sloan Nichola Duckworth Sarah Walsh Chris Denning C Patrick McClure Andrew Source Type: research

Profile of specific antibodies to the SARS-CoV-2
J Med Microbiol. 2021 Mar 18. doi: 10.1099/jmm.0.001335. Online ahead of print.ABSTRACTIn this work, we studied the profile of IgM and IgG antibody responses to SARS-CoV-2 in 32 patients with COVID-19 from day 1 to day 24. IgM remained measurable for a much shorter period than IgG, suggesting that IgG antibody may represent the primary immune response.PMID:33734961 | DOI:10.1099/jmm.0.001335 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 18, 2021 Category: Microbiology Authors: Danlei Mou Huahua Feng Ruiyuan Cao Xing Weng Lizhe Zhao Lingling Yang Ronghua Jin Weijun Chen Source Type: research

Profiles of mutations in hepatitis B virus surface and polymerase genes isolated from treatment-na ïve Nigerians infected with genotype E
Conclusion. The results of this study contribute to further understanding of HBV variability in Nigeria and the West African region. This will aid the planning of adequate HBV immunization and treatment programmes for the countries in the region.PMID:33704041 | DOI:10.1099/jmm.0.001338 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 11, 2021 Category: Microbiology Authors: Babatunde A Olusola Adedayo O Faneye Olukunle O Oluwasemowo Babatunde O Motayo Sopeju Adebayo Ayomide E Oludiran-Ayoade Bisola Aleru Uwem E George Arthur O Oragwa Source Type: research

Evaluation of true point of care molecular assay using fingerstick capillary whole blood for diagnosis of hepatitis C infection
J Med Microbiol. 2021 Mar 11. doi: 10.1099/jmm.0.001332. Online ahead of print.ABSTRACTAt present, the available point of care (POC) molecular assays for hepatitis C are not considered as true POC due to sample collection and processing requiring minimal laboratory infrastructure. A new POC Xpert HCV VL Fingerstick (Xpert FS) precludes such requirements where specimen collected by simple fingerstick can be loaded directly into the test cartridge with results available within 60 min. The present study compared the performance of this assay for HCV RNA quantitation using both capillary whole blood (CWB) and venous whole bloo...
Source: Journal of Medical Microbiology - March 11, 2021 Category: Microbiology Authors: Reshu Agarwal Ekta Gupta Guresh Kumar Keshaw Kumar Singh Manoj Kumar Sharma Source Type: research

Genomic investigation of clinically significant coagulase-negative staphylococci
Conclusion. Genomic investigation provides insights into the genetic diversity and natural history of colonization and infection. Such information allows the development of new methodologies to identify and compare relatedness and predict antimicrobial resistance. Future clinical studies that employ suitable sampling frames coupled with the application of high-resolution whole-genome sequencing may aid the development of more discriminatory diagnostic approaches to coagulase-staphylococcal infection.PMID:33704043 | DOI:10.1099/jmm.0.001337 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 11, 2021 Category: Microbiology Authors: Kevin Cole Bridget Atkins Martin Llewelyn John Paul Source Type: research

Emergence of a plasmid-borne tigecycline resistance in < em > Klebsiella pneumoniae < /em > in Vietnam
In this study, we identified K. pneumoniae isolates harbouring the tmexCD1-toprJ1 genes outside of China for the first time. Two tigecycline-resistant K. pneumoniae isolates belonging to ST273 by multilocus sequence typing were collected from different patients in a medical institution in Hanoi, Vietnam, in 2015. Whole-genome sequence analysis revealed that these isolates harboured a 288.0 kb tmexCD1-toprJ1-carrying plasmid with IncFIB and IncHI1B replicons. The tmexCD1-toprJ1 gene cluster was surrounded by several mobile gene elements, including IS26, and the plasmids had high sequence identity with that of K. pneumoniae ...
Source: Journal of Medical Microbiology - March 11, 2021 Category: Microbiology Authors: Aki Hirabayashi Van Thi Thu Ha An Van Nguyen Son Thai Nguyen Keigo Shibayama Masato Suzuki Source Type: research

Profiles of mutations in hepatitis B virus surface and polymerase genes isolated from treatment-na ïve Nigerians infected with genotype E
Conclusion. The results of this study contribute to further understanding of HBV variability in Nigeria and the West African region. This will aid the planning of adequate HBV immunization and treatment programmes for the countries in the region.PMID:33704041 | DOI:10.1099/jmm.0.001338 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 11, 2021 Category: Microbiology Authors: Babatunde A Olusola Adedayo O Faneye Olukunle O Oluwasemowo Babatunde O Motayo Sopeju Adebayo Ayomide E Oludiran-Ayoade Bisola Aleru Uwem E George Arthur O Oragwa Source Type: research

Evaluation of true point of care molecular assay using fingerstick capillary whole blood for diagnosis of hepatitis C infection
J Med Microbiol. 2021 Mar 11. doi: 10.1099/jmm.0.001332. Online ahead of print.ABSTRACTAt present, the available point of care (POC) molecular assays for hepatitis C are not considered as true POC due to sample collection and processing requiring minimal laboratory infrastructure. A new POC Xpert HCV VL Fingerstick (Xpert FS) precludes such requirements where specimen collected by simple fingerstick can be loaded directly into the test cartridge with results available within 60 min. The present study compared the performance of this assay for HCV RNA quantitation using both capillary whole blood (CWB) and venous whole bloo...
Source: Journal of Medical Microbiology - March 11, 2021 Category: Microbiology Authors: Reshu Agarwal Ekta Gupta Guresh Kumar Keshaw Kumar Singh Manoj Kumar Sharma Source Type: research

Genomic investigation of clinically significant coagulase-negative staphylococci
Conclusion. Genomic investigation provides insights into the genetic diversity and natural history of colonization and infection. Such information allows the development of new methodologies to identify and compare relatedness and predict antimicrobial resistance. Future clinical studies that employ suitable sampling frames coupled with the application of high-resolution whole-genome sequencing may aid the development of more discriminatory diagnostic approaches to coagulase-staphylococcal infection.PMID:33704043 | DOI:10.1099/jmm.0.001337 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 11, 2021 Category: Microbiology Authors: Kevin Cole Bridget Atkins Martin Llewelyn John Paul Source Type: research

Emergence of a plasmid-borne tigecycline resistance in < em > Klebsiella pneumoniae < /em > in Vietnam
In this study, we identified K. pneumoniae isolates harbouring the tmexCD1-toprJ1 genes outside of China for the first time. Two tigecycline-resistant K. pneumoniae isolates belonging to ST273 by multilocus sequence typing were collected from different patients in a medical institution in Hanoi, Vietnam, in 2015. Whole-genome sequence analysis revealed that these isolates harboured a 288.0 kb tmexCD1-toprJ1-carrying plasmid with IncFIB and IncHI1B replicons. The tmexCD1-toprJ1 gene cluster was surrounded by several mobile gene elements, including IS26, and the plasmids had high sequence identity with that of K. pneumoniae ...
Source: Journal of Medical Microbiology - March 11, 2021 Category: Microbiology Authors: Aki Hirabayashi Van Thi Thu Ha An Van Nguyen Son Thai Nguyen Keigo Shibayama Masato Suzuki Source Type: research

Profiles of mutations in hepatitis B virus surface and polymerase genes isolated from treatment-na ïve Nigerians infected with genotype E
Conclusion. The results of this study contribute to further understanding of HBV variability in Nigeria and the West African region. This will aid the planning of adequate HBV immunization and treatment programmes for the countries in the region.PMID:33704041 | DOI:10.1099/jmm.0.001338 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 11, 2021 Category: Microbiology Authors: Babatunde A Olusola Adedayo O Faneye Olukunle O Oluwasemowo Babatunde O Motayo Sopeju Adebayo Ayomide E Oludiran-Ayoade Bisola Aleru Uwem E George Arthur O Oragwa Source Type: research