Rethinking < em > Clostridioides difficile < /em > infection (CDI) surveillance definitions based on changing healthcare utilisation and a more realistic incubation period: reviewing data from a tertiary-referral hospital, Ireland, 2012 to 2021
ConclusionCDI surveillance specifications reflecting healthcare exposure and an incubation period more characteristic of C. difficile may improve targeted CDI prevention interventions.PMID:38333935 | PMC:PMC10853979 | DOI:10.2807/1560-7917.ES.2024.29.6.2300335 (Source: Euro Surveill)
Source: Euro Surveill - February 9, 2024 Category: Infectious Diseases Authors: Mairead Skally Kathleen Bennett Hilary Humphreys Fidelma Fitzpatrick Source Type: research
Regulatory workshop on challenge strain development and GMP manufacture - A stakeholder meeting report
Biologicals. 2024 Feb 2:101746. doi: 10.1016/j.biologicals.2024.101746. Online ahead of print.ABSTRACTWithin the Innovative Health Initiative (IHI) Inno4Vac CHIMICHURRI project, a regulatory workshop was organised on the development and manufacture of challenge agent strains for Controlled Human Infection Model (CHIM) studies. Developers are often uncertain about which GMP requirements or regulatory guidelines apply but should be guided by the 2022 technical white paper "Considerations on the Principles of Development and Manufacturing Qualities of Challenge Agents for Use in Human Infection Models" (published by hVIVO, We...
Source: Biologicals : Journal of the International Association of Biological Standardization - February 3, 2024 Category: Biotechnology Authors: Nicoletta Corti Christopher Chiu Rebecca J Cox Clarisse Demont Jeanne-Marie Devaster Othmar G Engelhardt Andrew Gorringe Khaole Hassan Marcel Hoefnagel Ingrid Kamerling Oleg Krut Chelsea Lane Reinhard Liebers Catherine Luke Wim Van Molle Sandra Morel Piet Source Type: research
Alterations in the gut microbiota and their metabolites in human intestinal epithelial cells of patients with colorectal cancer
CONCLUSIONS: The influence of bacterial metabolites on inflammation and altered expression of genes in the cell signaling pathways was observed. The findings confirm the role gut microbiota composition and bacterial metabolites as key players in CRC onset and development.PMID:38302841 | DOI:10.1007/s11033-024-09273-3 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - February 1, 2024 Category: Molecular Biology Authors: Somayeh Jahani-Sherafat Masoumeh Azimirad Hamideh Raeisi Mehdi Azizmohammad Looha Sajjad Tavakkoli Hamed Ahmadi Amoli Sharareh Moghim Mohammad Rostami-Nejad Abbas Yadegar Mohammad Reza Zali Source Type: research
Primary Prevention of Clostridium Difficile Infection with Oral Vancomycin in Pediatric Hematopoietic Stem Cell Transplant Patients
Clostridioides difficile is a toxin forming bacteria responsible for 223,900 cases and 12,800 deaths reported to the CDC in 2017. Risk factors for initial C. difficile infection (CDI) include broad-spectrum antibiotics and inpatient hospitalization. A uniquely susceptible population are pediatric hematopoietic stem cell transplant (HSCT) patients due to interruptions of gastrointestinal microbiota and compromised mucosal barriers. More than 20% of HSCT patients have CDI for which oral vancomycin prophylaxis (OVP) has been shown to be effective as secondary prophylaxis. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Heather Valdin, Blake Gray, Gregory Cook, Mackenzie Creamer, Zhide Fang, Zachary LeBlanc Tags: 191 Source Type: research
Hospital and related resource costs associated with antimicrobial-resistant infections in Canada, 2019
CONCLUSION: Quantifying the outcomes associated with antimicrobial-resistant infections provides valuable information for policymakers and is an essential first step in understanding the total economic impacts of AMR.PMID:38292392 | PMC:PMC10827302 | DOI:10.14745/ccdr.v48i1112a06 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - January 31, 2024 Category: Infectious Diseases Authors: Alan Diener Hui Wang Miriam Nkangu Source Type: research
