Clostridium Difficile Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Diagnostic performance of a multiplexed gastrointestinal PCR panel for identifying diarrheal pathogens in children undergoing hematopoietic stem cell transplant
CONCLUSIONS: Our data show that more than half of pediatric patients who were admitted for HSCT were colonized with various gastrointestinal pathogens, and more than one-third of these pathogens were associated with post-transplantation diarrhea. In addition, the FilmArray GI panel can increase the detection rate of diarrheal pathogens in pediatric HSCT patients, but the panel needs to be optimized for pathogen species, and further studies assessing its clinical impact and cost-effectiveness in this specific patient population are also needed.PMID:38367140 | DOI:10.1007/s12519-023-00776-w (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - February 17, 2024 Category: Pediatrics Authors: Yue Tao Cheng-Juan Luo Bing-Hua Zhang Xin-Yan Shen Rui-Ke Zhao Bei-Ying Ma Nan Shen Chang-Ying Luo Jian-Min Wang Yi-Jun Xia Li Xie Jing Chen Xi Mo Source Type: research

Antibacterial activity of ibezapolstat against antimicrobial-resistant clinical strains of Clostridioides difficile 
This study demonstrated the potent antibacterial activity of IBZ against a large collection of C. difficile strains including multidrug-resistant strains. This study highlights the therapeutic potential of IBZ against multidrug-resistant strains of C. difficile.PMID:38364016 | DOI:10.1128/aac.01621-23 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - February 16, 2024 Category: Microbiology Authors: Eug énie Bassères Taryn A Eubank Khurshida Begum M Jahangir Alam Jinhee Jo Thanh M Le Chris K Lancaster Anne J Gonzales-Luna Kevin W Garey Source Type: research

Estimating excess mortality and economic burden of Clostridioides difficile infections and recurrences during 2015 –2019: The RECUR England study
Clostridioides difficile is a common source of healthcare-associated infection, with symptoms ranging from mild diarrhoea to life-threatening colon damage [1,2]. While most C. difficile infection (CDI) cases are acquired in healthcare facilities, the incidence of community-associated CDIs has been increasing [1,3]. Nearly a quarter of patients experience a recurrent CDI (rCDI) episode. The recurrence rate increases with each subsequent episode, and 40% –65% of patients with one recurrence experience ≥2 recurrences [4]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 15, 2024 Category: Infectious Diseases Authors: Subrata Ghosh, Ana Antunes, Hanna Rinta-Kokko, Elena Chaparova, Sarah Lay-Flurrie, Aurore Tricotel, Fredrik L Andersson Source Type: research

Usefulness of a new immunochromatographic assay using fluorescent silica nanoparticles for serodiagnosis of Thai patients with amebiasis
Drug Discov Ther. 2024 Feb 15. doi: 10.5582/ddt.2023.01102. Online ahead of print.ABSTRACTA fluorescence immunochromatography (FIC) kit was developed recently using fluorescent silica nanoparticles coated with a recombinant C-terminal fragment of the surface lectin intermediate subunit (C-Igl) of Entamoeba histolytica to establish rapid serodiagnosis of amebiasis. We further evaluated the system using serum samples from 52 Thai patients with amebiasis. Of the patients, 50 (96%) tested positive using FIC. The samples were also tested using enzyme-linked immunosorbent assay (ELISA) with C-Igl as the antigen. Two samples were...
Source: Drug Discoveries and Therapeutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Azumi Kakino Urassaya Pattanawong Napaporn Kuamsab Tatsuya Imai Chaturong Putaporntip Satomi Asai Xunjia Cheng Somchai Jongwutiwes Hiroshi Tachibana Source Type: research

Molecular docking, dynamics and in vitro analysis of multi-target inhibitors for Clostridioides difficile 
Bioinformation. 2024 Jan 31;20(1):39-48. doi: 10.6026/973206300200039. eCollection 2024.ABSTRACTThe opportunistic pathogen, Clostridioides difficile owes its extreme pathogenicity for its ability to develop antibiotic resistance and recurrent infections. The current antibiotics used for the treatment are showing declining sensitivity and rising antibiotic resistance. Therefore, it is of interest to develop the anti-clostridial drugs to overcome these issues. Hence, we have explored ZINC library to find the suitable lead compounds against five target proteins of C. difficile. Multistep virtual screening is performed to find...
Source: Bioinformation - February 14, 2024 Category: Bioinformatics Authors: Nikita Chordia Golchha Hasanain Abdulhameed Odhar Anand Nighojkar Sadhana Nighojkar Source Type: research