A clinical study to determine the threshold of bronchodilator response for diagnosing asthma in Chinese children.
CONCLUSION: A BDR threshold of ≥ 7.5% has more value in childhood asthma diagnosis as compared to ≥ 12%. PMID: 31420819 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - August 16, 2019 Category: Pediatrics Authors: Kang XH, Wang W, Cao L Tags: World J Pediatr Source Type: research

Maternal exposure to antibiotics increases the risk of infant eczema before one year of life: a meta-analysis of observational studies.
CONCLUSIONS: Maternal exposure to antibiotics is associated with eczema by one-year age and may have a prolonged effect on eczema after 1-year age. The influence of timing of antibiotics exposure during pregnancy needs more studies to clarify. PMID: 31410707 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - August 13, 2019 Category: Pediatrics Authors: Huang FQ, Lu CY, Wu SP, Gong SZ, Zhao Y Tags: World J Pediatr Source Type: research

Epidemiological characteristics of childhood obesity in eastern China, 2017-2019.
PMID: 31407142 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - August 13, 2019 Category: Pediatrics Authors: Zhang XY, Yang WY, Yang J, Wang Y, Xiang Y, Gao LW, Zhang FY, Zhou YL Tags: World J Pediatr Source Type: research

Big challenges: obesity and type 2 diabetes in children and adolescents.
PMID: 31399907 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - August 10, 2019 Category: Pediatrics Authors: Fu JF Tags: World J Pediatr Source Type: research

Toward a better understanding of type I interferonopathies: a brief summary, update and beyond.
CONCLUSIONS: Tremendous progress has been made for the discovery of type I interferonopathies and responsible genes. Janus kinase inhibitors and other agents have potential therapeutic roles. Future basic, translational and clinical studies towards disease monitoring and powerful therapies are warranted. PMID: 31377974 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - August 3, 2019 Category: Pediatrics Authors: Yu ZX, Song HM Tags: World J Pediatr Source Type: research

Attenuated MuV-S79 as vector stably expressing foreign gene.
CONCLUSION: rMuV-S79 is a promising platform to accommodate foreign genes like marker genes, other antigens and immunomodulators for addressing various diseases. PMID: 31377975 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - August 3, 2019 Category: Pediatrics Authors: Zhou D, Zhu MY, Wang YL, Hao XQ, Zhou DM, Liu RX, Zhang CD, Qu CF, Zhao ZY Tags: World J Pediatr Source Type: research

Acute poisoning: an old-time classic issue in pediatrics.
PMID: 31372843 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - August 1, 2019 Category: Pediatrics Authors: Gkentzi D, Sinopidis X, Gourdoupi D, Mentis M, Karatza A, Dimitriou G Tags: World J Pediatr Source Type: research

Identification in Chinese patients with GLIALCAM mutations of megalencephalic leukoencephalopathy with subcortical cysts and brain pathological study on Glialcam knock-in mouse models.
CONCLUSIONS: Clinical and genetic characterization of patients with MLC and GLIALCAM mutations revealed a novel mutation, expanding the spectrum of GLIALCAM mutations. The first Glialcam mouse model with autosomal recessive inheritance and a new Glialcam mouse model with autosomal dominant inheritance were generated. The two mouse models with different modes of inheritance showed different degrees of brain pathological features, which were consistent with the patients' phenotype and further confirmed the pathogenicity of the corresponding mutations. PMID: 31372844 [PubMed - as supplied by publisher] (Source: World Jou...
Source: World Journal of Pediatrics : WJP - August 1, 2019 Category: Pediatrics Authors: Shi Z, Yan HF, Cao BB, Guo MM, Xie H, Gao K, Xiao JX, Yang YL, Xiong H, Gu Q, Li M, Wu Y, Jiang YW, Wang JM Tags: World J Pediatr Source Type: research

A review of isolated muscular ventricular septal defect.
CONCLUSIONS: This paper presents a review of the history of the diagnosis and frequency of ventricular septal defect, with discussion of its natural history from the fetal period to after birth in patients with isolated muscular ventricular septal defect. PMID: 31347020 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - July 25, 2019 Category: Pediatrics Authors: Miyake T Tags: World J Pediatr Source Type: research

Diagnosis and treatment of herpangina: Chinese expert consensus.
CONCLUSION: The consensus could provide advices and references for the diagnosis, treatment and management of herpangina in children. PMID: 31347021 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - July 25, 2019 Category: Pediatrics Authors: Yu H, Li XW, Liu QB, Deng HL, Liu G, Jiang RM, Deng JK, Ye YZ, Hao JH, Chen YH, Nong GM, Shen ZB, Liu CS, Zou YX, Wu JZ, Wu XD, Chen BQ, Luo RP, Lin AW, Chen Y, Liu XD Tags: World J Pediatr Source Type: research

Neonatal pemphigus vulgaris characterized by tensive blisters.
PMID: 31347022 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - July 25, 2019 Category: Pediatrics Authors: Yin GW, Li XY Tags: World J Pediatr Source Type: research

Inpatient use of racemic epinephrine for children admitted with croup.
CONCLUSIONS: Patients hospitalized for croup with recent use of steroids prior to ED presentation have a greater need for> 2 RE during hospitalization. The majority who require inpatient RE will do so within 8-12 hours. These data provide information for risk stratification and duration of monitoring for patients hospitalized with croup. PMID: 31342466 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - July 25, 2019 Category: Pediatrics Authors: Chiang E, Afandi O, Lee SH, Suresh S, Pitetti RD, Ramgopal S Tags: World J Pediatr Source Type: research

Association of image-defined risk factors, tumor resectability, and prognosis in children with localized neuroblastoma.
CONCLUSIONS: The number of IDRFs was useful in predicting surgical outcome and event-free survival. The number of IDRFs should be considered in protocol planning, instead of IDRF presence or absence. PMID: 31342464 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - July 24, 2019 Category: Pediatrics Authors: Zhang AA, Pan C, Xu M, Wang XX, Ye QD, Gao YJ, Tang JY Tags: World J Pediatr Source Type: research

Efficacy and adverse effects of oral propranolol in infantile hemangioma: a meta-analysis of comparative studies.
Abstract BACKGROUND: A number of clinical trials evaluated the efficacy and adverse effects of oral propranolol in the treatment of infantile hemangioma (IH), but the treatment has not yet been standardized. This meta-analysis aims to reevaluate the efficacy and adverse effects of oral propranolol in comparative studies and to provide a reliable basis for clinical administration in the therapy for IH. METHODS: Data were obtained from PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure and Wanfang database, from inception to December 1st, 2018. The pooled risk ratios (RR) ...
Source: World Journal of Pediatrics : WJP - July 24, 2019 Category: Pediatrics Authors: Yang H, Hu DL, Shu Q, Guo XD Tags: World J Pediatr Source Type: research

Prevention and treatment of childhood and adolescent obesity: a systematic review of meta-analyses.
CONCLUSIONS: Synthesis of interventional or observational evidence may yield discrepant results. The combination of enhanced physical activity and improved nutrition emerged as a promising intervention in the fight against childhood/adolescent obesity. However, further research is needed about the most effective multidimensional prevention strategy. PMID: 31313240 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - July 16, 2019 Category: Pediatrics Authors: Psaltopoulou T, Tzanninis S, Ntanasis-Stathopoulos I, Panotopoulos G, Kostopoulou M, Tzanninis IG, Tsagianni A, Sergentanis TN Tags: World J Pediatr Source Type: research

Impact of maternal smoking on the infant gut microbiota and its association with child overweight: a scoping review.
CONCLUSION: The limited evidence to date warrants further large scale, longitudinal studies to explore the impact of maternal smoking and environmental tobacco smoke on the infant gut microbiome and its relation to child overweight. PMID: 31290060 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - July 9, 2019 Category: Pediatrics Authors: McLean C, Jun S, Kozyrskyj A Tags: World J Pediatr Source Type: research

Family socioeconomic position and abnormal birth weight: evidence from a Chinese birth cohort.
CONCLUSIONS: Socioeconomic disparities in fetal macrosomia and LBW exist in Southern China. Whether the results can be applied to other populations should be further investigated. PMID: 31286424 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - July 8, 2019 Category: Pediatrics Authors: Tu S, Wang AL, Tan MZ, Lu JH, He JR, Shen SY, Wei DM, Lu MS, Au Yeung SL, Xia HM, Qiu X Tags: World J Pediatr Source Type: research

Impact of HIV on the health-related quality of life in youth with perinatally acquired HIV.
This study aimed to compare HRQoL of PHIV+ to sociodemographic-matched youth not living with HIV (HIV-), Spanish general youth population, and to explore associations between sociodemographic variables, drug consumption, and HRQoL. METHODS: PHIV+ youth were randomly selected from CoRISpe database (Cohort of the Spanish Pediatric HIV Network). HRQoL was evaluated by SF-12v2. RESULTS: Thirty-nine PHIV+ youth (mean age: 23.36 years, SD = 3.83) and thirty-nine HIV- youth (mean age: 22.97 years, SD = 3.80) participated in this study. PHIV+ obt...
Source: World Journal of Pediatrics : WJP - July 8, 2019 Category: Pediatrics Authors: Cuéllar-Flores I, Saínz T, Velo C, González-Tomé MI, García-Navarro C, Fernández-Mcphee C, Guillén S, Ramos JT, Miralles P, Rubio R, Bernardino JI, Prieto L, Rojo P, de Ory SJ, Navarro ML, CoRiSpe (FARO and NeuroCoRISpeS projects, RITIP -Traslation Tags: World J Pediatr Source Type: research

Effect of hand hygiene intervention on the absenteeism of pre-school children in Klang Valley, Malaysia: a quasi-experimental study.
Abstract BACKGROUND: Absenteeism amongst pre-school children is often due to illnesses such as hand, foot, and mouth disease, acute gastroenteritis, cold and flu, which are easily spread amongst them. This is because of weak immunity and lack of knowledge on proper hand hygiene. This quasi-experimental study assessed the efficacy of an intervention consisting of a hand hygiene education programme, along with digital tools in bringing about a change in behaviour and health conditions amongst pre-school children in Klang Valley, Malaysia. METHODS: A total of 377 school children, male and female, aged 5-6 y...
Source: World Journal of Pediatrics : WJP - July 8, 2019 Category: Pediatrics Authors: Mohamed NA, Mohd Rani MD, Tengku Jamaluddin TZM, Ismail Z, Ramli S, Faroque H, Abd Samad FN, Ariffien AR, Che Amir Farid AAR, Isahak I Tags: World J Pediatr Source Type: research

Incidence of congenital heart diseases in Chinese children with non-syndromic congenital blepharoptosis: a prospective observational study of 1053 patients.
CONCLUSIONS: We found an increased frequency of CHD in CBP children, suggesting a clinical need for routine echocardiography evaluation in CBP, especially in children with severe or bilateral ptosis. PMID: 31267383 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - July 2, 2019 Category: Pediatrics Authors: Zeng LF, Tang ZD, Gu J, Wang CQ, Zhang HL Tags: World J Pediatr Source Type: research

Is a nasogastric tube necessary after transumbilical laparoscopic-assisted appendectomy in children with perforated appendicitis?
This study assessed the necessity of postoperative nasogastric tube (NGT) use in acute pediatric cases of perforated appendicitis. METHODS: All cases of acute pediatric perforated appendicitis managed with transumbilical laparoscopic-assisted appendectomy at our hospital from 2011 to 2017 were retrospectively reviewed. Sixty-two cases were selected and divided into two groups based on NGT placement. RESULTS: There were no significant differences between the two groups in most parameters of patient demographics, or surgical data. Notably, the mean time to first oral intake and to regular diet was significantly sho...
Source: World Journal of Pediatrics : WJP - June 26, 2019 Category: Pediatrics Authors: Sekioka A, Fukumoto K, Takahashi T, Miyake H, Nakaya K, Nomura A, Yamada Y, Urushihara N Tags: World J Pediatr Source Type: research

Impact of dyslipidemia on estimated glomerular filtration rate in apparently healthy children and adolescents: the CASPIAN-V study.
CONCLUSION: The study showed that dyslipidemia is associated with reduced eGFR among the healthy children and adolescents. PMID: 31240635 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - June 25, 2019 Category: Pediatrics Authors: Moafi M, Assadi F, Heshmat R, Khoshhali M, Qorbani M, Motlagh ME, Dashti R, Taheri M, Kelishadi R Tags: World J Pediatr Source Type: research

Community-acquired serious bacterial infections in the first 90 days of life: a revisit in the era of multi-drug-resistant organisms.
CONCLUSIONS: The bacteriology of SBIs in the first 90 days of life is changing to include more MDROs, which causes more delay in providing targeted antimicrobial therapy. Awareness of the local epidemiology is crucial to ensure appropriate antibiotics are provided in a timely manner. PMID: 31230257 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - June 22, 2019 Category: Pediatrics Authors: Yusef D, Jahmani T, Kailani S, Al-Rawi R, Khasawneh W, Almomani M Tags: World J Pediatr Source Type: research

Factors associated with exclusive breastfeeding in relation to knowledge, attitude and practice of breastfeeding mothers in Rabigh community, Western Saudi Arabia.
CONCLUSION: Findings of this study should be utilized by Rabigh community and other national or worldwide communities with similar characters to promote EBF by targeted educational programs after identification of significant factors influencing EBF and gaps in KAP of BFM. PMID: 31214890 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - June 18, 2019 Category: Pediatrics Authors: Hegazi MA, Allebdi M, Almohammadi M, Alnafie A, Al-Hazmi L, Alyoubi S Tags: World J Pediatr Source Type: research

Forkhead box M1 transcription factor: a novel target for pulmonary arterial hypertension therapy.
CONCLUSIONS: FoxM1 has a crucial role in the pathogenesis of pulmonary arterial hypertension and may represent a novel therapeutic target. But more details of interaction between FoxM1 and other signaling pathways need to be clarified in the future. PMID: 31190319 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - June 12, 2019 Category: Pediatrics Authors: Gu L, Liu HM Tags: World J Pediatr Source Type: research

Management of Wilms tumor with intravenous thrombus in children: a single center experience.
CONCLUSION: Standardized sequential treatment, including preoperative chemotherapy and radiotherapy, nephrectomy combining resection of thrombus, postoperative adjuvant therapy, is the mainstay of treatment of Wilms tumor with intravenous thrombus. PMID: 31161446 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - June 3, 2019 Category: Pediatrics Authors: Xu S, Sun N, Zhang WP, Song HC, Huang CR Tags: World J Pediatr Source Type: research

Fluoroquinolones-resistant Shigella species in Iranian children: a meta-analysis.
CONCLUSIONS: Our findings revealed that ciprofloxacin can still be used as the first-line antibiotic for Shigella infections in Iranian children. However, it seems that second-line antibiotics i.e., ceftriaxone and azithromycin are not good choices for treatment and thus not recommended. PMID: 31154582 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - June 1, 2019 Category: Pediatrics Authors: Khademi F, Sahebkar A Tags: World J Pediatr Source Type: research

Gianotti-Crosti syndrome (papular acrodermatitis of childhood) in the era of a viral recrudescence and vaccine opposition.
CONCLUSIONS: Gianotti-Crosti syndrome is mainly a disease of early childhood, characterized by an acute onset of a papular or papulovesicular eruption with a symmetrical distribution. With the advent of more universal vaccination against hepatitis B virus, Epstein-Barr virus has become the most common etiologic agent of Gianotti-Crosti syndrome. Few cases of post-vaccination Gianotti-Crosti syndrome have been reported. Currently, the emphasis should be placed on its self-limiting attribution. PMID: 31134587 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 27, 2019 Category: Pediatrics Authors: Leung AKC, Sergi CM, Lam JM, Leong KF Tags: World J Pediatr Source Type: research

The role of gut micorbiome in obesity and diabetes.
CONCLUSIONS: The gut microbiome has been shown to be an important part of the metabolic processes. The use of probiotic, prebiotics and symbiotics is promising, but requires further investigations to determine the specific metabolic effects of each bacteria strain and substance. PMID: 31134588 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 27, 2019 Category: Pediatrics Authors: Górowska-Kowolik K, Chobot A Tags: World J Pediatr Source Type: research

FTO gene polymorphisms and obesity risk in Chinese population: a meta-analysis.
Abstract BACKGROUND: There is tremendous increase in obesity worldwide. Many factors including diet, life style, genetic, and epigenetic changes contribute to obesity. The fat mass and obesity-associated (FTO) gene polymorphisms are strongly associated with obesity. It has been reported that FTO single-nucleotide polymorphisms (SNPs) are associated with obesity in European populations; however, it was controversial in Chinese population. The present meta-analysis study was designed to investigate the association between FTO polymorphisms and obesity risk in Chinese population. METHODS: The investigators ...
Source: World Journal of Pediatrics : WJP - May 23, 2019 Category: Pediatrics Authors: Zhao NN, Dong GP, Wu W, Wang JL, Ullah R, Fu JF Tags: World J Pediatr Source Type: research

MicroRNA-125b regulates Th17/Treg cell differentiation and is associated with juvenile idiopathic arthritis.
CONCLUSIONS: Our results demonstrate that miR-125b participated in regulating Th17/Treg cell differentiation and imbalance in JIA patients. These findings provide novel insight into the critical role of miR-125b in the Th17/Treg imbalance of JIA, and raise the distinct possibility that miR-125b may prove to be a potential therapeutic target for JIA. PMID: 31102153 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 17, 2019 Category: Pediatrics Authors: Fan ZD, Cao Q, Huang N, Ma L, Ma HH, Zhang YY, Yu HG, Zhou GP Tags: World J Pediatr Source Type: research

Sedation and analgesia in children with cerebral palsy: a narrative review.
CONCLUSIONS: Large trials are needed to assess the impact of non-pharmacological techniques and to evaluate which pain control strategy (pharmacological and non-pharmacological) should be used in different settings. PMID: 31098933 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 16, 2019 Category: Pediatrics Authors: Rabach I, Peri F, Minute M, Aru E, Lucafò M, Di Mascio A, Cozzi G, Barbi E Tags: World J Pediatr Source Type: research

Distal renal tubular acidosis: genetic causes and management.
CONCLUSIONS: dRTA is a multifactorial disease leading to several clinical manifestations. Clinical and laboratory alterations can be corrected by alkali replacement therapy. PMID: 31079338 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 11, 2019 Category: Pediatrics Authors: Soares SBM, de Menezes Silva LAW, de Carvalho Mrad FC, Simões E Silva AC Tags: World J Pediatr Source Type: research

Childhood obesity in New Zealand.
CONCLUSIONS: The prevalence of overweight and obese children and adolescents in New Zealand is markedly high, with a greater impact on particular ethnicities and those of lower socioeconomic status. Alleviating the current burden of pediatric obesity should be a key priority for New Zealand, for the benefit of both current and subsequent generations. Future strategies should focus on obesity prevention, particularly starting at a young age and targeting those at greatest risk. PMID: 31079339 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 11, 2019 Category: Pediatrics Authors: Chiavaroli V, Gibbins JD, Cutfield WS, Derraik JGB Tags: World J Pediatr Source Type: research

Progress in understanding youth-onset type 2 diabetes in the United States: recent lessons from clinical trials.
CONCLUSIONS: Both TODAY and RISE studies have provided critical insight into the unique aspects of the pathophysiology of youth-onset type 2 diabetes and also provided the evidence base for our current approach to the management of this disorder. PMID: 31077083 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 10, 2019 Category: Pediatrics Authors: Zeitler P Tags: World J Pediatr Source Type: research

Early testing of insulin resistance: a tale of two lipid ratios in a group of 5th graders screened by the Coronary Artery Risk Detection in Appalachian Communities Project (CARDIAC Project).
Abstract BACKGROUND: In West Virginia (WV), 47% of fifth-grade children are either overweight or obese. There is no clear consensus regarding the definition of insulin resistance in children, and directly measuring insulin on the population level is costly. Two proposed measures examined further in this study include triglyceride (TRIG)/high-density lipoprotein cholesterol (HDL-C) ratio and TRIG/low-density lipoprotein (LDL-C) ratio. The purpose of this study is to examine the relationship between TRIG/HDL-C ratio, TRIG/LDL-C ratio and insulin resistance in fifth-graders with acanthosis nigricans (AN). METHOD...
Source: World Journal of Pediatrics : WJP - May 4, 2019 Category: Pediatrics Authors: Mosimah CI, Lilly C, Forbin AN, Murray PJ, Pyles L, Elliot E, Neal W Tags: World J Pediatr Source Type: research

Cardiovascular dysfunction and vitamin D status in childhood acute lymphoblastic leukemia survivors.
Abstract BACKGROUND: Vitamin D (25-OHD) has a role in bone health after treatment for cancer. 25-OHD deficiency has been associated with risk factors for cardiovascular disease, but no data focusing on this topic in childhood cancer survivors have been published. We investigated the 25-OHD status in children treated for acute lymphoblastic leukemia (ALL), and evaluated its influence on vascular function. METHODS: 25-OHD levels were evaluated in 52 ALL survivors and 40 matched healthy controls. Patients were grouped according to 25-OHD level (
Source: World Journal of Pediatrics : WJP - May 4, 2019 Category: Pediatrics Authors: Muggeo P, Muggeo VMR, Giordano P, Delvecchio M, Altomare M, Novielli C, Ciccone MM, D'Amato G, Faienza MF, Santoro N Tags: World J Pediatr Source Type: research

Correction to: Exhaustive mathematical analysis of simple clinical measurements for childhood pneumonia diagnosis.
Abstract In the original publication of the article "Declaration of conflict of interest" were not included. The following text is given below. PMID: 31049813 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - May 2, 2019 Category: Pediatrics Authors: Kosasih K, Abeyratne U Tags: World J Pediatr Source Type: research

Efficacy and safety of tacrolimus and low-dose prednisone in Chinese children with steroid-resistant nephrotic syndrome.
Abstract BACKGROUND: Tacrolimus, a calcineurin inhibitor, is recommended by the recent guidelines from the Kidney Disease Improving Global Outcomes Group as the first-line treatment for steroid-resistant nephrotic syndrome (SRNS), but its clinical application in China is still limited. We investigated the efficacy and safety of tacrolimus combined with low-dose corticosteroids in a population of Chinese children with SRNS. METHODS: In this prospective non-randomized, non-controlled study, Chinese children with SRNS who failed the previous full-dose prednisone treatment were given tacrolimus (0.1 mg/kg/da...
Source: World Journal of Pediatrics : WJP - May 2, 2019 Category: Pediatrics Authors: Chen HX, Cheng Q, Li F, He QN, Cao Y, Yi ZW, Wu XC Tags: World J Pediatr Source Type: research

Optimization and application of a dried blood spot-based genetic screening method for thalassemia in Shenzhen newborns.
CONCLUSIONS: Genetic screening based on DBS can precisely identify the thalassemia genotypes. Both α- and β-thalassemia are widely distributed in Shenzhen newborns. Newborn genetic screening is important for establishing a comprehensive thalassemia prevention program and for public education. PMID: 31030386 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - April 27, 2019 Category: Pediatrics Authors: Wen W, Guo M, Peng HB, Ma L Tags: World J Pediatr Source Type: research

Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection.
Abstract BACKGROUND: Recurrent respiratory tract infection (RRTI) is a disease occurred frequently in preschool children. METHODS: A total of 120 RRTI children were randomly divided into active group, remission group, intervention group and control group, meanwhile 30 healthy children were selected as the healthy group. Children in the intervention group were given oral Bifidobaeterium tetravaccine tablets (Live) for 2 months, while the control group received routine treatment. Stool sample were detected to analyze the bacterial strains. The occurrence of respiratory tract infection (RTI) was compared be...
Source: World Journal of Pediatrics : WJP - April 24, 2019 Category: Pediatrics Authors: Li KL, Wang BZ, Li ZP, Li YL, Liang JJ Tags: World J Pediatr Source Type: research

DOCK8 deficiency with mediastinal lymph node tuberculosis.
PMID: 31016565 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - April 23, 2019 Category: Pediatrics Authors: Zhang LQ, Li XB, Bao YG Tags: World J Pediatr Source Type: research

Efficacy of different analgesic or sedative drug therapies in pediatric patients with congenital heart disease undergoing surgery: a network meta-analysis.
CONCLUSIONS: Overall, based on the comprehensive consideration of all the endpoints, fentanyl combined with dexmedetomidine was considered to be the best-recommended clinical interventions among all the methods. PMID: 31016566 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - April 23, 2019 Category: Pediatrics Authors: Liu RZ, Li BT, Zhao GQ Tags: World J Pediatr Source Type: research

Clinical features in proven and probable invasive fungal disease in children and adolescents at a pediatric referral center: a 5-year experience.
CONCLUSION: Our results suggest the emergence of non-albicans Candida species as important pathogens in childhood IFD. PMID: 31011987 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - April 22, 2019 Category: Pediatrics Authors: Kishimoto K, Kasai M, Kawamura N, Ito Y, Yoshida M, Hasegawa D, Kawasaki K, Kosaka Y Tags: World J Pediatr Source Type: research

Application of artificial intelligence in pediatrics: past, present and future.
PMID: 30997653 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - April 17, 2019 Category: Pediatrics Authors: Shu LQ, Sun YK, Tan LH, Shu Q, Chang AC Tags: World J Pediatr Source Type: research

A negative regulator of synaptic development: MDGA and its links to neurodevelopmental disorders.
CONCLUSION: MDGAs play a key role in neuron migration, axon guidance and synapse development, as well as in regulating brain excitation and inhibition balance. PMID: 30997654 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - April 17, 2019 Category: Pediatrics Authors: Wang R, Dong JX, Wang L, Dong XY, Anenberg E, Jiang PF, Zeng LH, Xie YC Tags: World J Pediatr Source Type: research

Risk factors for recurrent macrosomia and child outcomes.
CONCLUSIONS: Fetal macrosomia has a high recurrence rate in the following pregnancy. Higher maternal pre-pregnant BMI and gestational weight gain are still important risk factors for recurrence of macrosomia, which in turn increases the risk for childhood obesity. PMID: 30993581 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - April 16, 2019 Category: Pediatrics Authors: Fang F, Zhang QY, Zhang J, Lei XP, Luo ZC, Cheng HD Tags: World J Pediatr Source Type: research

Magnetic resonance spectroscopy in Leigh-MELAS overlap syndrome.
PMID: 30968306 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - April 9, 2019 Category: Pediatrics Authors: Ko A, Lee YM Tags: World J Pediatr Source Type: research

Tribute to Reviewers (January 1, 2018-December 31, 2018).
Authors: PMID: 30955167 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - April 6, 2019 Category: Pediatrics Tags: World J Pediatr Source Type: research

Clinical characteristics and beta-cell function of Chinese children and adolescents with type 2 diabetes from 2009 to 2018.
Abstract BACKGROUND: The limited available studies have unveiled different natural histories and prognosis associated with pediatric type 2 diabetes (T2D) and adult T2D. To date, data on the clinical features, metabolic profiles and beta-cell function characteristics are still limited in the Chinese pediatric T2D population. METHODS: A total of 56 children with T2D, 31 with prediabetes and 159 with obesity were recruited. Clinical characteristics, metabolic profiles, beta-cell function and insulin resistance were analyzed. RESULTS: The mean onset age of T2D was 12.35 ± 1.99 (7.9-17.8...
Source: World Journal of Pediatrics : WJP - March 25, 2019 Category: Pediatrics Authors: Xu ZR, Zhang MY, Ni JW, Cheng RQ, Zheng ZQ, Xi L, Luo FH Tags: World J Pediatr Source Type: research